IFNA20P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle cell cellular homeostasis (GO:0046716)7.85573890
2synaptonemal complex assembly (GO:0007130)7.29844113
3regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)7.24000102
4bundle of His cell to Purkinje myocyte communication (GO:0086069)6.84698750
5synapsis (GO:0007129)6.73610097
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.63299907
7chromosome organization involved in meiosis (GO:0070192)6.49401028
8synaptonemal complex organization (GO:0070193)6.19677253
9muscle filament sliding (GO:0030049)5.96215268
10actin-myosin filament sliding (GO:0033275)5.96215268
11DNA strand renaturation (GO:0000733)5.62298410
12myoblast fusion (GO:0007520)5.53126083
13negative regulation of potassium ion transmembrane transport (GO:1901380)5.51503970
14male meiosis I (GO:0007141)5.36537186
15syncytium formation by plasma membrane fusion (GO:0000768)5.29520633
16actin-mediated cell contraction (GO:0070252)5.24418204
17DNA synthesis involved in DNA repair (GO:0000731)5.16245127
18regulation of skeletal muscle contraction (GO:0014819)4.88266377
19plasma membrane fusion (GO:0045026)4.85313924
20meiosis I (GO:0007127)4.76463649
21syncytium formation (GO:0006949)4.69699989
22meiotic nuclear division (GO:0007126)4.57840604
23positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.57480097
24regulation of interferon-beta biosynthetic process (GO:0045357)4.52417007
25regulation of striated muscle contraction (GO:0006942)4.41973186
26skeletal muscle contraction (GO:0003009)4.40019634
27piRNA metabolic process (GO:0034587)4.18747032
28endosome to melanosome transport (GO:0035646)4.16660089
29endosome to pigment granule transport (GO:0043485)4.16660089
30regulation of sarcomere organization (GO:0060297)4.08572893
31positive regulation of microtubule polymerization (GO:0031116)3.95197281
32actin filament-based movement (GO:0030048)3.94007381
33killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.92659283
34disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.92659283
35postsynaptic membrane organization (GO:0001941)3.86998235
36heart process (GO:0003015)3.86332543
37heart contraction (GO:0060047)3.86332543
38negative regulation of nitric-oxide synthase activity (GO:0051001)3.83813042
39negative regulation of protein localization to cell surface (GO:2000009)3.72861773
40blood vessel maturation (GO:0001955)3.67452269
41negative regulation of growth of symbiont in host (GO:0044130)3.60812609
42negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.60812609
43modulation of growth of symbiont involved in interaction with host (GO:0044144)3.60812609
44regulation of growth of symbiont in host (GO:0044126)3.60812609
45positive regulation of toll-like receptor signaling pathway (GO:0034123)3.45223606
46macrophage differentiation (GO:0030225)3.40511492
47protein maturation by protein folding (GO:0022417)3.38683205
48protein-chromophore linkage (GO:0018298)3.35823456
49meiotic cell cycle process (GO:1903046)3.31118178
50negative regulation of monooxygenase activity (GO:0032769)3.31058324
51musculoskeletal movement (GO:0050881)3.28734965
52multicellular organismal movement (GO:0050879)3.28734965
53regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.27116164
54positive regulation of myotube differentiation (GO:0010831)3.21375441
55neuromuscular synaptic transmission (GO:0007274)3.19034132
56negative regulation of interleukin-8 production (GO:0032717)3.16605535
57male meiosis (GO:0007140)3.08291284
58positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.07198480
59regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.99623008
60regulation of translation in response to stress (GO:0043555)2.98891835
61regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.98522663
62plasma membrane repair (GO:0001778)2.97540576
63neutrophil mediated immunity (GO:0002446)2.96824599
64establishment of integrated proviral latency (GO:0075713)2.92711825
65DNA methylation involved in gamete generation (GO:0043046)2.92454043
66single strand break repair (GO:0000012)2.91832375
67negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.89538620
68reciprocal DNA recombination (GO:0035825)2.88596415
69reciprocal meiotic recombination (GO:0007131)2.88596415
70I-kappaB phosphorylation (GO:0007252)2.86676379
71negative regulation of cardiac muscle hypertrophy (GO:0010614)2.86631846
72glycosphingolipid catabolic process (GO:0046479)2.85339127
73cardiac myofibril assembly (GO:0055003)2.80353226
74positive regulation of interferon-alpha production (GO:0032727)2.80328891
75histone H3-K36 demethylation (GO:0070544)2.77735968
76modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.76415625
77positive regulation by organism of defense response of other organism involved in symbiotic interact2.76415625
78modulation by symbiont of host immune response (GO:0052553)2.76415625
79positive regulation by symbiont of host defense response (GO:0052509)2.76415625
80modulation by symbiont of host defense response (GO:0052031)2.76415625
81modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.76415625
82sarcomere organization (GO:0045214)2.76048783
83regulation of interferon-alpha production (GO:0032647)2.74436910
84striated muscle contraction (GO:0006941)2.73468257
85female mating behavior (GO:0060180)2.71856556
86negative regulation of cell killing (GO:0031342)2.71463058
87negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.71463058
88regulation of NFAT protein import into nucleus (GO:0051532)2.70018419
89cytokine biosynthetic process (GO:0042089)2.69411246
90positive regulation of gamma-delta T cell activation (GO:0046645)2.68778081
91regulation of cardiac muscle contraction (GO:0055117)2.63991313
92germinal center formation (GO:0002467)2.63778927
93response to peptidoglycan (GO:0032494)2.62645476
94positive regulation of cellular amide metabolic process (GO:0034250)2.59006936
95regulation of podosome assembly (GO:0071801)2.58722526
96nerve growth factor signaling pathway (GO:0038180)2.55438903
97negative regulation of muscle hypertrophy (GO:0014741)2.53102147
98regulation of relaxation of muscle (GO:1901077)2.51542419
99establishment of viral latency (GO:0019043)2.51214848
100substrate-dependent cell migration (GO:0006929)2.50746628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse5.42299620
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.88170017
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.37508053
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.14024642
5VDR_21846776_ChIP-Seq_THP-1_Human3.06081577
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.97404781
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.90391140
8WT1_19549856_ChIP-ChIP_CCG9911_Human2.64996679
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.59224827
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55199628
11GATA1_22025678_ChIP-Seq_K562_Human2.51941708
12E2F7_22180533_ChIP-Seq_HELA_Human2.43887299
13VDR_24763502_ChIP-Seq_THP-1_Human2.40247992
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.29909030
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.26611512
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.19640007
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08412471
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07196049
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05478850
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04438497
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.04098632
22SPI1_23547873_ChIP-Seq_NB4_Human2.03922665
23SCL_19346495_ChIP-Seq_HPC-7_Human1.97676631
24TFEB_21752829_ChIP-Seq_HELA_Human1.94689004
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88174934
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85898566
27MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77313016
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76355009
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.75814669
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69520720
31MYB_26560356_Chip-Seq_TH1_Human1.62287661
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61296580
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60787449
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.57709768
35PU_27001747_Chip-Seq_BMDM_Mouse1.57225853
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54648331
37MYC_22102868_ChIP-Seq_BL_Human1.53500103
38NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.48342322
39MAF_26560356_Chip-Seq_TH2_Human1.48056769
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.44897251
41UTX_26944678_Chip-Seq_JUKART_Human1.44510511
42MYB_26560356_Chip-Seq_TH2_Human1.43696564
43TBX20_22080862_ChIP-Seq_HEART_Mouse1.41371041
44TBX20_22328084_ChIP-Seq_HEART_Mouse1.41371041
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.39159109
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39101527
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36904272
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34636802
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31828576
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30125275
51SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29769950
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29327759
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29095282
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27234721
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25935083
56SPI1_23127762_ChIP-Seq_K562_Human1.23466400
57GATA3_26560356_Chip-Seq_TH2_Human1.21672815
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20715887
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19985110
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.19251617
61MAF_26560356_Chip-Seq_TH1_Human1.18350962
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14917785
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.13086135
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12988372
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12159277
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09267546
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.08305791
68GATA3_26560356_Chip-Seq_TH1_Human1.06835532
69GATA3_27048872_Chip-Seq_THYMUS_Human1.06197359
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05313182
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03611823
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00054253
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96674501
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95554985
75TCF7_22412390_ChIP-Seq_EML_Mouse0.95425638
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95061339
77CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91985655
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91813764
79EP300_21415370_ChIP-Seq_HL-1_Mouse0.89447343
80GATA1_19941827_ChIP-Seq_MEL_Mouse0.89192584
81IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86876105
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.86781041
83BRD4_25478319_ChIP-Seq_HGPS_Human0.86190097
84CTCF_26484167_Chip-Seq_Bcells_Mouse0.86029327
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83963330
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83317490
87DCP1A_22483619_ChIP-Seq_HELA_Human0.83095939
88RUNX_20019798_ChIP-Seq_JUKART_Human0.81626216
89KDM2B_26808549_Chip-Seq_DND41_Human0.81386252
90RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81023926
91VDR_24787735_ChIP-Seq_THP-1_Human0.80290566
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80214013
93CTCF_21964334_Chip-Seq_Bcells_Human0.79596171
94EGR1_19374776_ChIP-ChIP_THP-1_Human0.79325980
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78757063
96RUNX1_26923725_Chip-Seq_HPCs_Mouse0.78450584
97E2F1_20622854_ChIP-Seq_HELA_Human0.77933749
98GATA4_21415370_ChIP-Seq_HL-1_Mouse0.77134430
99GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76733575
100NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.76576808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation7.23164685
2MP0000749_muscle_degeneration5.03912962
3MP0004510_myositis3.81575150
4MP0003950_abnormal_plasma_membrane3.41352044
5MP0002736_abnormal_nociception_after3.19602345
6MP0005058_abnormal_lysosome_morphology3.11508824
7MP0005451_abnormal_body_composition2.64198996
8MP0008058_abnormal_DNA_repair2.62263783
9MP0001849_ear_inflammation2.45209533
10MP0000751_myopathy2.39398852
11MP0003172_abnormal_lysosome_physiology2.38960793
12MP0003279_aneurysm2.10409777
13MP0003436_decreased_susceptibility_to1.98729110
14MP0008789_abnormal_olfactory_epithelium1.96841049
15MP0004233_abnormal_muscle_weight1.88067610
16MP0004084_abnormal_cardiac_muscle1.80978979
17MP0000465_gastrointestinal_hemorrhage1.71628739
18MP0002419_abnormal_innate_immunity1.71384754
19MP0005248_abnormal_Harderian_gland1.62719272
20MP0001835_abnormal_antigen_presentation1.60584252
21MP0001968_abnormal_touch/_nociception1.52016546
22MP0008004_abnormal_stomach_pH1.50709181
23MP0005387_immune_system_phenotype1.50661043
24MP0001790_abnormal_immune_system1.50661043
25MP0001851_eye_inflammation1.48979439
26MP0005167_abnormal_blood-brain_barrier1.47147258
27MP0006082_CNS_inflammation1.46658633
28MP0006054_spinal_hemorrhage1.45893170
29MP0003763_abnormal_thymus_physiology1.45765810
30MP0003724_increased_susceptibility_to1.44943572
31MP0002396_abnormal_hematopoietic_system1.43363023
32MP0010155_abnormal_intestine_physiology1.40876066
33MP0004484_altered_response_of1.40215423
34MP0005025_abnormal_response_to1.35814901
35MP0000759_abnormal_skeletal_muscle1.32566001
36MP0005499_abnormal_olfactory_system1.30441715
37MP0005394_taste/olfaction_phenotype1.30441715
38MP0002148_abnormal_hypersensitivity_rea1.29747351
39MP0010352_gastrointestinal_tract_polyps1.28446195
40MP0003868_abnormal_feces_composition1.26753618
41MP0001986_abnormal_taste_sensitivity1.26458153
42MP0003448_altered_tumor_morphology1.25305574
43MP0004036_abnormal_muscle_relaxation1.24375548
44MP0005000_abnormal_immune_tolerance1.23320415
45MP0003011_delayed_dark_adaptation1.19249118
46MP0001958_emphysema1.18710781
47MP0002452_abnormal_antigen_presenting1.18659007
48MP0003300_gastrointestinal_ulcer1.17261496
49MP0002269_muscular_atrophy1.15311590
50MP0002723_abnormal_immune_serum1.13987096
51MP0005464_abnormal_platelet_physiology1.12900733
52MP0001819_abnormal_immune_cell1.11582420
53MP0002420_abnormal_adaptive_immunity1.10751471
54MP0003828_pulmonary_edema1.10579789
55MP0003091_abnormal_cell_migration1.09916584
56MP0001915_intracranial_hemorrhage1.09896415
57MP0009785_altered_susceptibility_to1.09207541
58MP0001800_abnormal_humoral_immune1.08441948
59MP0002405_respiratory_system_inflammati1.05054822
60MP0004883_abnormal_blood_vessel1.03875187
61MP0003221_abnormal_cardiomyocyte_apopto1.00692741
62MP0002398_abnormal_bone_marrow0.98111359
63MP0000015_abnormal_ear_pigmentation0.97840509
64MP0000767_abnormal_smooth_muscle0.96463387
65MP0000685_abnormal_immune_system0.94803608
66MP0000747_muscle_weakness0.94364875
67MP0001533_abnormal_skeleton_physiology0.93872613
68MP0004087_abnormal_muscle_fiber0.92596767
69MP0000716_abnormal_immune_system0.91898336
70MP0002933_joint_inflammation0.91495307
71MP0000490_abnormal_crypts_of0.90962593
72MP0001845_abnormal_inflammatory_respons0.90464665
73MP0003646_muscle_fatigue0.90081717
74MP0008260_abnormal_autophagy0.89997565
75MP0001663_abnormal_digestive_system0.88690567
76MP0002722_abnormal_immune_system0.86106484
77MP0000343_altered_response_to0.84541347
78MP0005310_abnormal_salivary_gland0.83669488
79MP0002106_abnormal_muscle_physiology0.82855250
80MP0000689_abnormal_spleen_morphology0.82738122
81MP0004808_abnormal_hematopoietic_stem0.82450374
82MP0005671_abnormal_response_to0.82320724
83MP0005330_cardiomyopathy0.82256837
84MP0008469_abnormal_protein_level0.81089317
85MP0009765_abnormal_xenobiotic_induced0.81067748
86MP0005165_increased_susceptibility_to0.80985668
87MP0005174_abnormal_tail_pigmentation0.80926373
88MP0002972_abnormal_cardiac_muscle0.77771830
89MP0003075_altered_response_to0.75659899
90MP0005023_abnormal_wound_healing0.74898297
91MP0005367_renal/urinary_system_phenotyp0.74019901
92MP0000516_abnormal_urinary_system0.74019901
93MP0002429_abnormal_blood_cell0.73807130
94MP0009764_decreased_sensitivity_to0.73779682
95MP0010234_abnormal_vibrissa_follicle0.72507801
96MP0008007_abnormal_cellular_replicative0.72408918
97MP0003385_abnormal_body_wall0.71107945
98MP0001756_abnormal_urination0.70725483
99MP0009763_increased_sensitivity_to0.68322282
100MP0005193_abnormal_anterior_eye0.67635377

Predicted human phenotypes

RankGene SetZ-score
1Type 2 muscle fiber atrophy (HP:0003554)7.67807717
2Muscle fiber atrophy (HP:0100295)7.22445288
3Popliteal pterygium (HP:0009756)6.69107851
4Amniotic constriction ring (HP:0009775)6.24907333
5Abnormality of placental membranes (HP:0011409)6.24907333
6Aplasia of the musculature (HP:0100854)6.15579006
7Fatigable weakness (HP:0003473)5.13828775
8Abnormality of the neuromuscular junction (HP:0003398)5.13828775
9Fetal akinesia sequence (HP:0001989)4.99668237
10Weak cry (HP:0001612)4.91552944
11Calf muscle hypertrophy (HP:0008981)4.71723813
12Gowers sign (HP:0003391)4.36944736
13Muscle hypertrophy of the lower extremities (HP:0008968)4.14940129
14Asymmetric septal hypertrophy (HP:0001670)3.93038247
15Ulnar deviation of the wrist (HP:0003049)3.92242638
16Abnormality of the left ventricular outflow tract (HP:0011103)3.87797976
17Subaortic stenosis (HP:0001682)3.87797976
18Malignant hyperthermia (HP:0002047)3.85521204
19Sudden death (HP:0001699)3.75705194
20Nemaline bodies (HP:0003798)3.75512815
21Exercise-induced myalgia (HP:0003738)3.72411524
22Easy fatigability (HP:0003388)3.68593220
23Akinesia (HP:0002304)3.65585102
24Dyschromatopsia (HP:0007641)3.64299024
25Subacute progressive viral hepatitis (HP:0006572)3.53780337
26Abnormality of the calf musculature (HP:0001430)3.53767117
27Aplasia/Hypoplasia involving the musculature (HP:0001460)3.36123453
28Deformed tarsal bones (HP:0008119)3.29663035
29Enlarged epiphyses (HP:0010580)3.17807332
30Thin ribs (HP:0000883)3.15998604
31Round ear (HP:0100830)3.09404058
32Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.97957104
33Viral hepatitis (HP:0006562)2.87264021
34Cystic hygroma (HP:0000476)2.81739966
35Late onset (HP:0003584)2.76035938
36Hypoplastic heart (HP:0001961)2.75993388
37Muscle fiber inclusion bodies (HP:0100299)2.73405080
38Bulbar palsy (HP:0001283)2.71978641
39Distal arthrogryposis (HP:0005684)2.58614215
40Exercise-induced muscle cramps (HP:0003710)2.58569354
41Neck muscle weakness (HP:0000467)2.43140182
42Limb-girdle muscle atrophy (HP:0003797)2.37035384
43Generalized muscle weakness (HP:0003324)2.32385048
44Pterygium (HP:0001059)2.32102899
45Calcaneovalgus deformity (HP:0001848)2.31517363
46Horizontal nystagmus (HP:0000666)2.24134342
47Chest pain (HP:0100749)2.18963826
48Type 1 muscle fiber predominance (HP:0003803)2.18864382
49Ovoid vertebral bodies (HP:0003300)2.16714594
50Thin bony cortex (HP:0002753)2.13416978
51Poor suck (HP:0002033)2.09785018
52Loss of speech (HP:0002371)2.08463699
53Left ventricular hypertrophy (HP:0001712)2.05133695
54Micronodular cirrhosis (HP:0001413)2.02426436
55Abnormality of dentin (HP:0010299)1.99581841
56Agammaglobulinemia (HP:0004432)1.98550227
57Gaze-evoked nystagmus (HP:0000640)1.97917481
58Respiratory insufficiency due to muscle weakness (HP:0002747)1.94343166
59Recurrent abscess formation (HP:0002722)1.92107523
60Spontaneous abortion (HP:0005268)1.89928827
61Stomatitis (HP:0010280)1.89380507
62Diminished movement (HP:0002374)1.87869485
63Spontaneous hematomas (HP:0007420)1.85626732
64Gastrointestinal infarctions (HP:0005244)1.85148975
65Trismus (HP:0000211)1.81622801
66Recurrent bacterial skin infections (HP:0005406)1.77650123
67Abnormality of macrophages (HP:0004311)1.77480808
68Capillary hemangiomas (HP:0005306)1.76495151
69Mucopolysacchariduria (HP:0008155)1.73533183
70Urinary glycosaminoglycan excretion (HP:0003541)1.73533183
71Recurrent cutaneous fungal infections (HP:0011370)1.72313459
72Chronic mucocutaneous candidiasis (HP:0002728)1.72313459
73Periodontitis (HP:0000704)1.72057408
74Abnormality of mucopolysaccharide metabolism (HP:0011020)1.70383229
75Abnormality of polysaccharide metabolism (HP:0011012)1.70383229
76Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70383229
77Broad distal phalanx of finger (HP:0009836)1.69573603
78Slender build (HP:0001533)1.65667601
79Lipoatrophy (HP:0100578)1.64210150
80Cervical subluxation (HP:0003308)1.63390779
81Nonprogressive disorder (HP:0003680)1.63182185
82Recurrent pneumonia (HP:0006532)1.63141296
83Metatarsus adductus (HP:0001840)1.62356048
84Adactyly (HP:0009776)1.61860589
85Sepsis (HP:0100806)1.61671067
86Dysostosis multiplex (HP:0000943)1.61050739
87Limb ataxia (HP:0002070)1.59857470
88Abnormalities of placenta or umbilical cord (HP:0001194)1.58546116
89Combined immunodeficiency (HP:0005387)1.56203423
90Cellulitis (HP:0100658)1.56034351
91Hip contracture (HP:0003273)1.54380757
92Epidermoid cyst (HP:0200040)1.51940576
93Papillary thyroid carcinoma (HP:0002895)1.50419625
94Dilated cardiomyopathy (HP:0001644)1.48680543
95Arthrogryposis multiplex congenita (HP:0002804)1.48608426
96Facial diplegia (HP:0001349)1.48157501
97Eczematoid dermatitis (HP:0000976)1.47121307
98Recurrent lower respiratory tract infections (HP:0002783)1.45468336
99Centrally nucleated skeletal muscle fibers (HP:0003687)1.44402155
100Azoospermia (HP:0000027)1.43953003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN3.88245235
2BRD43.28370664
3AKT33.25132598
4PIK3CG3.08551815
5VRK23.04056279
6DDR22.65867129
7ERN12.61956036
8BCKDK2.46155002
9MAP3K142.16908265
10NEK92.12123876
11CDK61.99227340
12PDK21.89895665
13BLK1.83704029
14STK381.74330109
15MAP3K101.71434552
16PRKD21.71423816
17PLK21.69077185
18CDK121.67766904
19MAP3K51.66572246
20RIPK41.58942152
21MARK11.58118113
22CDK191.55657347
23CSK1.48371011
24MARK21.42899182
25LIMK11.41785269
26MUSK1.34499045
27CSNK1G21.33494609
28IRAK31.33168973
29MAP3K71.33010461
30MAPK151.29410086
31MAP3K111.20942519
32CSNK1G11.17376492
33MAPK111.17019243
34MAPK41.15684595
35MAP3K91.15317501
36PKN21.09072505
37CAMKK21.08605431
38CAMK11.06301249
39SGK21.05612114
40MAP2K31.04121991
41PRPF4B1.03921497
42SGK31.01818901
43SMG11.00573407
44EIF2AK30.99529834
45BTK0.95745733
46CSNK1A1L0.95382909
47CSNK1G30.94852425
48CDK90.92199746
49JAK30.90958786
50RPS6KA40.90155851
51CDK40.88447788
52MAPK70.86733357
53FES0.85664996
54CAMK40.85508362
55SIK10.81917618
56PTK2B0.81457720
57IRAK40.78406574
58GRK60.77802982
59TAOK20.74906180
60NEK60.73826316
61GRK70.70882813
62SIK30.70654381
63DYRK1B0.70038525
64TYK20.68106636
65MAP3K30.67591503
66JAK10.67540119
67CDK80.66003945
68TESK20.65451339
69TIE10.62917108
70CSF1R0.62504786
71SGK4940.61207588
72SGK2230.61207588
73VRK10.59078752
74YES10.58752286
75EGFR0.57799665
76MAPK120.57522579
77MELK0.57397258
78SYK0.57383103
79NME10.55838327
80FLT30.55837262
81TXK0.53131715
82MAP4K10.53000553
83HCK0.52526784
84ZAP700.51327216
85PDPK10.51326743
86TAOK10.50992756
87TAOK30.50961666
88EEF2K0.50144528
89TBK10.47356880
90PDGFRB0.47283470
91PAK40.46282507
92MOS0.42702124
93TTN0.42407628
94JAK20.41424586
95PKN10.37622170
96LYN0.35874650
97LRRK20.35195995
98NUAK10.34791266
99GSK3A0.34436471
100IKBKE0.34347015

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.79464994
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.69126143
3Other glycan degradation_Homo sapiens_hsa005112.55222495
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.53546095
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.18265564
6Malaria_Homo sapiens_hsa051442.16697393
7Viral myocarditis_Homo sapiens_hsa054162.08852245
8Dilated cardiomyopathy_Homo sapiens_hsa054142.08155399
9Lysosome_Homo sapiens_hsa041422.07560892
10Primary immunodeficiency_Homo sapiens_hsa053402.07338561
11Osteoclast differentiation_Homo sapiens_hsa043801.98916068
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.88902793
13Tuberculosis_Homo sapiens_hsa051521.79160631
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.75815603
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.72359556
16Non-homologous end-joining_Homo sapiens_hsa034501.64750289
17Homologous recombination_Homo sapiens_hsa034401.64660583
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61621834
19Measles_Homo sapiens_hsa051621.60937955
20Leishmaniasis_Homo sapiens_hsa051401.58411471
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.54670564
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48130637
23Legionellosis_Homo sapiens_hsa051341.44790759
24Herpes simplex infection_Homo sapiens_hsa051681.41762677
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37050760
26Pertussis_Homo sapiens_hsa051331.29952660
27TNF signaling pathway_Homo sapiens_hsa046681.24723324
28African trypanosomiasis_Homo sapiens_hsa051431.21363319
29Staphylococcus aureus infection_Homo sapiens_hsa051501.20425893
30Toxoplasmosis_Homo sapiens_hsa051451.17982907
31Basal transcription factors_Homo sapiens_hsa030221.17651153
32Circadian rhythm_Homo sapiens_hsa047101.13910576
33Phagosome_Homo sapiens_hsa041451.09491488
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.08346750
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08066810
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.05413833
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05105199
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03282123
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02723460
40B cell receptor signaling pathway_Homo sapiens_hsa046621.01909656
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01731910
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01228671
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00897509
44Acute myeloid leukemia_Homo sapiens_hsa052210.99756883
45Influenza A_Homo sapiens_hsa051640.99212374
46Allograft rejection_Homo sapiens_hsa053300.98700642
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97885875
48Graft-versus-host disease_Homo sapiens_hsa053320.96227291
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91535584
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90036578
51Hepatitis B_Homo sapiens_hsa051610.89226403
52Hematopoietic cell lineage_Homo sapiens_hsa046400.88562050
53Galactose metabolism_Homo sapiens_hsa000520.88042786
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.86592262
55Antigen processing and presentation_Homo sapiens_hsa046120.86266862
56Epstein-Barr virus infection_Homo sapiens_hsa051690.85726943
57Renin-angiotensin system_Homo sapiens_hsa046140.84885682
58Hepatitis C_Homo sapiens_hsa051600.83876259
59Rheumatoid arthritis_Homo sapiens_hsa053230.83834801
60Bladder cancer_Homo sapiens_hsa052190.82197986
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79477846
62HTLV-I infection_Homo sapiens_hsa051660.78253108
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76958291
64Propanoate metabolism_Homo sapiens_hsa006400.76270885
65Apoptosis_Homo sapiens_hsa042100.76184709
66Small cell lung cancer_Homo sapiens_hsa052220.70719210
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70310108
68Shigellosis_Homo sapiens_hsa051310.69766532
69TGF-beta signaling pathway_Homo sapiens_hsa043500.69376968
70Proteoglycans in cancer_Homo sapiens_hsa052050.69240586
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69192448
72Focal adhesion_Homo sapiens_hsa045100.69008745
73mTOR signaling pathway_Homo sapiens_hsa041500.68788693
74HIF-1 signaling pathway_Homo sapiens_hsa040660.68417070
75Platelet activation_Homo sapiens_hsa046110.68063192
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67797891
77Colorectal cancer_Homo sapiens_hsa052100.67619581
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66333707
79Chemokine signaling pathway_Homo sapiens_hsa040620.66237675
80Autoimmune thyroid disease_Homo sapiens_hsa053200.65548864
81Endocytosis_Homo sapiens_hsa041440.64682834
82Pancreatic cancer_Homo sapiens_hsa052120.64306245
83Amoebiasis_Homo sapiens_hsa051460.63556118
84Sulfur relay system_Homo sapiens_hsa041220.62378938
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.61630813
86Insulin resistance_Homo sapiens_hsa049310.60680626
87MicroRNAs in cancer_Homo sapiens_hsa052060.60374623
88Glucagon signaling pathway_Homo sapiens_hsa049220.58035297
89Inositol phosphate metabolism_Homo sapiens_hsa005620.57915312
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56592673
91Sphingolipid metabolism_Homo sapiens_hsa006000.56147547
92Asthma_Homo sapiens_hsa053100.55552601
93Salmonella infection_Homo sapiens_hsa051320.55509100
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54428531
95T cell receptor signaling pathway_Homo sapiens_hsa046600.53116866
96FoxO signaling pathway_Homo sapiens_hsa040680.52746705
97Viral carcinogenesis_Homo sapiens_hsa052030.52648433
98AMPK signaling pathway_Homo sapiens_hsa041520.48248936
99Non-small cell lung cancer_Homo sapiens_hsa052230.47271448
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.46277660

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