IFNAR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)4.89362109
2modulation by symbiont of host defense response (GO:0052031)4.89362109
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.89362109
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.89362109
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.89362109
6modulation by symbiont of host immune response (GO:0052553)4.89362109
7positive regulation of gamma-delta T cell activation (GO:0046645)4.86855325
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.67955681
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.53244187
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.53244187
11antigen processing and presentation of endogenous antigen (GO:0019883)4.38873627
12regulation of interleukin-12 biosynthetic process (GO:0045075)4.06970298
13regulation of B cell receptor signaling pathway (GO:0050855)3.99673205
14regulation of interferon-beta biosynthetic process (GO:0045357)3.90081904
15detection of external biotic stimulus (GO:0098581)3.76345162
16positive thymic T cell selection (GO:0045059)3.66126577
17regulation of gamma-delta T cell differentiation (GO:0045586)3.61031800
18regulation of gamma-delta T cell activation (GO:0046643)3.54372119
19macrophage activation involved in immune response (GO:0002281)3.54026285
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.51465835
21negative regulation of cell killing (GO:0031342)3.51465835
22positive regulation of interferon-alpha production (GO:0032727)3.48497886
23response to muramyl dipeptide (GO:0032495)3.45673095
24detection of other organism (GO:0098543)3.41460246
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.35265200
26regulation of interferon-alpha production (GO:0032647)3.32650032
27lipopolysaccharide-mediated signaling pathway (GO:0031663)3.29712126
28T-helper 1 type immune response (GO:0042088)3.24767138
29regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.23184657
30negative T cell selection (GO:0043383)3.17520869
31negative thymic T cell selection (GO:0045060)3.16334738
32neutrophil mediated immunity (GO:0002446)3.10831570
33T cell migration (GO:0072678)3.10414679
34detection of biotic stimulus (GO:0009595)3.09907468
35response to host immune response (GO:0052572)3.06926993
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.06926993
37tolerance induction (GO:0002507)3.05629955
38germinal center formation (GO:0002467)3.05478499
39pinocytosis (GO:0006907)3.04174692
40regulation of T cell tolerance induction (GO:0002664)3.02847959
41negative regulation of lymphocyte mediated immunity (GO:0002707)3.01925480
42production of molecular mediator involved in inflammatory response (GO:0002532)3.00231733
43interferon-gamma-mediated signaling pathway (GO:0060333)2.99042949
44response to host (GO:0075136)2.98815603
45response to host defenses (GO:0052200)2.98815603
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.98815603
47response to peptidoglycan (GO:0032494)2.97336359
48regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97012652
49immunoglobulin mediated immune response (GO:0016064)2.96493109
50JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.96084707
51substrate-dependent cell migration (GO:0006929)2.95977270
52leukocyte aggregation (GO:0070486)2.94816360
53I-kappaB phosphorylation (GO:0007252)2.92865165
54* response to type I interferon (GO:0034340)2.91223596
55neutrophil activation involved in immune response (GO:0002283)2.90842257
56positive T cell selection (GO:0043368)2.90798529
57B cell receptor signaling pathway (GO:0050853)2.90420263
58NIK/NF-kappaB signaling (GO:0038061)2.90229799
59cell adhesion mediated by integrin (GO:0033627)2.89824098
60detection of bacterium (GO:0016045)2.88751080
61* type I interferon signaling pathway (GO:0060337)2.87527290
62* cellular response to type I interferon (GO:0071357)2.87527290
63myeloid leukocyte mediated immunity (GO:0002444)2.86450441
64positive regulation of antigen processing and presentation (GO:0002579)2.85474418
65positive regulation of interferon-beta production (GO:0032728)2.83951196
66thymic T cell selection (GO:0045061)2.83589218
67negative regulation of T cell mediated immunity (GO:0002710)2.81942586
68cellular extravasation (GO:0045123)2.79390096
69cellular response to ethanol (GO:0071361)2.79047359
70response to laminar fluid shear stress (GO:0034616)2.76069646
71positive regulation of B cell differentiation (GO:0045579)2.74667101
72negative regulation of leukocyte mediated immunity (GO:0002704)2.73444494
73microglial cell activation (GO:0001774)2.71882430
74dendritic cell migration (GO:0036336)2.71160766
75positive regulation of macrophage cytokine production (GO:0060907)2.71129699
76interferon-gamma production (GO:0032609)2.69799930
77negative regulation of granulocyte differentiation (GO:0030853)2.69601515
78regulation of cholesterol storage (GO:0010885)2.68708772
79regulation of interleukin-8 biosynthetic process (GO:0045414)2.68600505
80B cell homeostasis (GO:0001782)2.68134541
81regulation of B cell differentiation (GO:0045577)2.66225424
82leukocyte cell-cell adhesion (GO:0007159)2.65966640
83myeloid leukocyte activation (GO:0002274)2.65241819
84positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.64194272
85detection of molecule of bacterial origin (GO:0032490)2.63620923
86defense response to protozoan (GO:0042832)2.63567028
87negative regulation of phagocytosis (GO:0050765)2.62059182
88cellular response to thyroid hormone stimulus (GO:0097067)2.60795399
89positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.60452779
90T cell selection (GO:0045058)2.60428242
91glycosphingolipid catabolic process (GO:0046479)2.60350873
92negative regulation of interleukin-12 production (GO:0032695)2.59954280
93regulation of alpha-beta T cell proliferation (GO:0046640)2.59923926
94positive regulation of mast cell activation (GO:0033005)2.59565973
95regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.59337622
96regulation of dendritic cell antigen processing and presentation (GO:0002604)2.58712102
97interleukin-6-mediated signaling pathway (GO:0070102)2.58566689
98positive regulation of toll-like receptor signaling pathway (GO:0034123)2.58084404
99hydrogen peroxide biosynthetic process (GO:0050665)2.57463007
100regulation of mast cell degranulation (GO:0043304)2.56157954
101protein localization to endosome (GO:0036010)2.55498330
102negative regulation of cytokine production involved in immune response (GO:0002719)2.55204761
103regulation of macrophage cytokine production (GO:0010935)2.53204852
104response to interleukin-15 (GO:0070672)2.51889074
105macrophage activation (GO:0042116)2.50966735
106dendritic cell chemotaxis (GO:0002407)2.50674803
107regulation of antigen processing and presentation (GO:0002577)2.50222945
108regulation of mast cell activation (GO:0033003)2.50182992
109positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.50128509
110iron ion import (GO:0097286)2.48195864
111positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.47920598
112myeloid cell activation involved in immune response (GO:0002275)2.47675067
113neutrophil chemotaxis (GO:0030593)2.47297761
114modulation by symbiont of host cellular process (GO:0044068)2.46642881
115neutrophil activation (GO:0042119)2.45893931
116regulation of interleukin-6 biosynthetic process (GO:0045408)2.44790247
117apoptotic cell clearance (GO:0043277)2.43873318
118regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.43344784
119regulation of mast cell activation involved in immune response (GO:0033006)2.43295276
120myeloid dendritic cell activation (GO:0001773)2.42937913
121antigen processing and presentation via MHC class Ib (GO:0002475)2.42455636
122neutrophil migration (GO:1990266)2.41905754
123oligosaccharide catabolic process (GO:0009313)2.41608650
124regulation of response to interferon-gamma (GO:0060330)2.41517121
125hepatocyte apoptotic process (GO:0097284)2.41493249
126positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.40895405
127response to protozoan (GO:0001562)2.40617371
128positive regulation of cellular amide metabolic process (GO:0034250)2.40604263
129T cell costimulation (GO:0031295)2.40229511
130leukocyte migration involved in inflammatory response (GO:0002523)2.40025755
131regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.39836254
132Arp2/3 complex-mediated actin nucleation (GO:0034314)2.39685617
133regulation of interleukin-12 production (GO:0032655)2.39100734
134regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.38338126
135respiratory burst (GO:0045730)2.38142109
136regulation of tolerance induction (GO:0002643)2.35836870
137myeloid dendritic cell differentiation (GO:0043011)2.34916729
138* regulation of type I interferon-mediated signaling pathway (GO:0060338)2.34345308
139lymphocyte costimulation (GO:0031294)2.33934147
140germ cell migration (GO:0008354)2.32935461
141granulocyte activation (GO:0036230)2.32760926
142positive regulation of cytokine biosynthetic process (GO:0042108)2.32517383
143positive regulation of interleukin-2 production (GO:0032743)2.31801293
144regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.30574784
145positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.30264680

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.29505260
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.78289895
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.24562998
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.24130433
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.17013314
6* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.81833872
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.46752119
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.39893477
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.05082141
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03883870
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02287548
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.92278545
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91620336
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.72107513
15RUNX_20019798_ChIP-Seq_JUKART_Human2.52258726
16* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.47942140
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46679121
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.37989268
19MYC_22102868_ChIP-Seq_BL_Human2.37374108
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.29483623
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.23746271
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.18959304
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16254544
24MAF_26560356_Chip-Seq_TH1_Human2.15280049
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.12227936
26SCL_19346495_ChIP-Seq_HPC-7_Human2.11527409
27MYB_26560356_Chip-Seq_TH2_Human2.06024672
28VDR_21846776_ChIP-Seq_THP-1_Human1.95825574
29TCF7_22412390_ChIP-Seq_EML_Mouse1.93589130
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91692911
31* MYB_26560356_Chip-Seq_TH1_Human1.80628428
32SPI1_23127762_ChIP-Seq_K562_Human1.79302780
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.76871217
34VDR_24763502_ChIP-Seq_THP-1_Human1.76285335
35UTX_26944678_Chip-Seq_JUKART_Human1.75239749
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75201213
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73934258
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72738705
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72562403
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68353748
41PU_27001747_Chip-Seq_BMDM_Mouse1.65259518
42* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64842250
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63934276
44GATA1_22025678_ChIP-Seq_K562_Human1.63527443
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.62170244
46KDM2B_26808549_Chip-Seq_DND41_Human1.56414789
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54310383
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53661634
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.52376799
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.50714795
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.49385839
52* SPI1_23547873_ChIP-Seq_NB4_Human1.49082280
53VDR_24787735_ChIP-Seq_THP-1_Human1.45097078
54CLOCK_20551151_ChIP-Seq_293T_Human1.32986956
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30857528
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30547479
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30207687
58* GATA3_27048872_Chip-Seq_THYMUS_Human1.26892608
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26404794
60NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24476982
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24476982
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22336052
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22314537
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20101016
65E2F7_22180533_ChIP-Seq_HELA_Human1.18833259
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15136077
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14522690
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12243197
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.11243024
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11142294
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11079331
72MAF_26560356_Chip-Seq_TH2_Human1.10430790
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.07703384
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04367690
75FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03449403
76WT1_19549856_ChIP-ChIP_CCG9911_Human1.02683327
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02182562
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01869269
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01737503
80SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01737503
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01296294
82FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00966498
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00694560
84FOXM1_23109430_ChIP-Seq_U2OS_Human0.99137094
85SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98982322
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98474203
87GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98015444
88GATA1_19941826_ChIP-Seq_K562_Human0.97353484
89* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96565425
90GATA2_19941826_ChIP-Seq_K562_Human0.96014289
91HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94964515
92* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93801574
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93130693
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92970175
95TRIM28_21343339_ChIP-Seq_HEK293_Human0.92734629
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.92383374
97LXR_22158963_ChIP-Seq_LIVER_Mouse0.91753416
98* TP53_16413492_ChIP-PET_HCT116_Human0.91392681
99PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90757615
100SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90395259
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90367414
102CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90125156
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90016285
104* NCOR1_26117541_ChIP-Seq_K562_Human0.89926179
105ESR1_20079471_ChIP-ChIP_T-47D_Human0.89797175
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89121205
107STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88683960
108SOX2_20726797_ChIP-Seq_SW620_Human0.88287441
109BRD4_25478319_ChIP-Seq_HGPS_Human0.87882231
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.87783306
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87711731
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87550910
113JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87241382
114NFE2_27457419_Chip-Seq_LIVER_Mouse0.87032516
115GATA3_26560356_Chip-Seq_TH2_Human0.87015897
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.86245644
117P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86027299
118EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85657052
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.84960053
120TP63_23658742_ChIP-Seq_EP156T_Human0.84222892
121SMRT_27268052_Chip-Seq_Bcells_Human0.82814643
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82755023
123RXR_22158963_ChIP-Seq_LIVER_Mouse0.82716676
124OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82394507
125NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81183056
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80967634
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79791165
128CRX_20693478_ChIP-Seq_RETINA_Mouse0.79656105
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79421958
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79294613
131CJUN_26792858_Chip-Seq_BT549_Human0.79265361
132* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78934756
133JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78795128
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.78330826
135PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78317702
136PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77486132

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.46616714
2MP0003436_decreased_susceptibility_to2.86547572
3MP0000685_abnormal_immune_system2.71426071
4MP0003303_peritoneal_inflammation2.64072353
5MP0005387_immune_system_phenotype2.62214565
6MP0001790_abnormal_immune_system2.62214565
7MP0003300_gastrointestinal_ulcer2.55342342
8MP0005671_abnormal_response_to2.50700451
9* MP0001800_abnormal_humoral_immune2.49563235
10MP0005000_abnormal_immune_tolerance2.44981282
11* MP0002419_abnormal_innate_immunity2.37425797
12* MP0002452_abnormal_antigen_presenting2.36024075
13MP0002166_altered_tumor_susceptibility2.34247775
14MP0000569_abnormal_digit_pigmentation2.22363184
15* MP0009785_altered_susceptibility_to2.17498348
16MP0003763_abnormal_thymus_physiology2.13353493
17* MP0002723_abnormal_immune_serum2.13018612
18MP0003705_abnormal_hypodermis_morpholog2.10329463
19* MP0005025_abnormal_response_to2.10106922
20* MP0001819_abnormal_immune_cell2.09392427
21* MP0002420_abnormal_adaptive_immunity2.09203178
22MP0009278_abnormal_bone_marrow2.06972708
23MP0002148_abnormal_hypersensitivity_rea1.96313628
24MP0006082_CNS_inflammation1.94370411
25MP0002006_tumorigenesis1.92122020
26MP0008260_abnormal_autophagy1.91336286
27MP0008438_abnormal_cutaneous_collagen1.90807965
28MP0002405_respiratory_system_inflammati1.89664876
29MP0004947_skin_inflammation1.88736838
30MP0010352_gastrointestinal_tract_polyps1.87077913
31MP0003690_abnormal_glial_cell1.85322796
32MP0005076_abnormal_cell_differentiation1.83139780
33* MP0002398_abnormal_bone_marrow1.75342898
34MP0003724_increased_susceptibility_to1.74847332
35MP0005464_abnormal_platelet_physiology1.73534591
36MP0010155_abnormal_intestine_physiology1.72584220
37MP0002139_abnormal_hepatobiliary_system1.72572141
38MP0003191_abnormal_cellular_cholesterol1.71894447
39MP0001533_abnormal_skeleton_physiology1.65727906
40MP0005058_abnormal_lysosome_morphology1.65643427
41MP0004510_myositis1.63960370
42* MP0000716_abnormal_immune_system1.63326113
43MP0004808_abnormal_hematopoietic_stem1.60323550
44MP0001853_heart_inflammation1.59961167
45MP0003566_abnormal_cell_adhesion1.59832106
46* MP0003448_altered_tumor_morphology1.59113645
47MP0009333_abnormal_splenocyte_physiolog1.56756068
48MP0003172_abnormal_lysosome_physiology1.56746143
49MP0000689_abnormal_spleen_morphology1.55212165
50* MP0001845_abnormal_inflammatory_respons1.54380925
51MP0001545_abnormal_hematopoietic_system1.47660081
52MP0005397_hematopoietic_system_phenotyp1.47660081
53MP0002722_abnormal_immune_system1.45314472
54MP0003195_calcinosis1.44682813
55MP0003183_abnormal_peptide_metabolism1.43859537
56MP0001873_stomach_inflammation1.42921943
57MP0002877_abnormal_melanocyte_morpholog1.42417395
58MP0005451_abnormal_body_composition1.41197039
59MP0003806_abnormal_nucleotide_metabolis1.40233921
60MP0002998_abnormal_bone_remodeling1.39601669
61MP0009840_abnormal_foam_cell1.37304814
62MP0000858_altered_metastatic_potential1.36273801
63MP0010307_abnormal_tumor_latency1.36105854
64* MP0002429_abnormal_blood_cell1.33558822
65MP0002933_joint_inflammation1.32416253
66MP0002396_abnormal_hematopoietic_system1.30590984
67MP0003045_fibrosis1.29683708
68MP0003091_abnormal_cell_migration1.28915701
69MP0000343_altered_response_to1.28138456
70MP0000703_abnormal_thymus_morphology1.27214419
71MP0003279_aneurysm1.26709309
72MP0006054_spinal_hemorrhage1.25490012
73MP0005023_abnormal_wound_healing1.24681916
74MP0003656_abnormal_erythrocyte_physiolo1.22112500
75MP0002138_abnormal_hepatobiliary_system1.20469843
76MP0005167_abnormal_blood-brain_barrier1.19977490
77MP0000767_abnormal_smooth_muscle1.19694226
78MP0000465_gastrointestinal_hemorrhage1.18920010
79MP0003828_pulmonary_edema1.17937490
80* MP0008469_abnormal_protein_level1.16407280
81MP0009764_decreased_sensitivity_to1.15903281
82MP0000920_abnormal_myelination1.12311904
83MP0002254_reproductive_system_inflammat1.06280084
84MP0005365_abnormal_bile_salt1.05926840
85MP0005174_abnormal_tail_pigmentation1.05259543
86MP0005085_abnormal_gallbladder_physiolo1.00631441
87MP0005310_abnormal_salivary_gland1.00204269
88MP0010368_abnormal_lymphatic_system0.99682543
89MP0000604_amyloidosis0.99307353
90MP0002009_preneoplasia0.99197755
91MP0000249_abnormal_blood_vessel0.98588025
92MP0005390_skeleton_phenotype0.96085261
93MP0001915_intracranial_hemorrhage0.94711107
94MP0002332_abnormal_exercise_endurance0.93949259
95MP0003329_amyloid_beta_deposits0.93416307
96MP0001958_emphysema0.93300143
97MP0009763_increased_sensitivity_to0.90496595
98MP0001851_eye_inflammation0.87357376
99MP0004883_abnormal_blood_vessel0.85847594
100MP0010386_abnormal_urinary_bladder0.83219928
101MP0005164_abnormal_response_to0.82567872
102MP0001879_abnormal_lymphatic_vessel0.81818440
103MP0000609_abnormal_liver_physiology0.81253151
104MP0000015_abnormal_ear_pigmentation0.80242571
105MP0003221_abnormal_cardiomyocyte_apopto0.80057158
106MP0003453_abnormal_keratinocyte_physiol0.79647841
107MP0008004_abnormal_stomach_pH0.79263595
108* MP0003795_abnormal_bone_structure0.78463799
109MP0002168_other_aberrant_phenotype0.77950509
110MP0002928_abnormal_bile_duct0.77922444
111MP0000371_diluted_coat_color0.77683054
112MP0002277_abnormal_respiratory_mucosa0.75915699
113MP0003950_abnormal_plasma_membrane0.75876937
114MP0005319_abnormal_enzyme/_coenzyme0.75610943
115MP0008874_decreased_physiological_sensi0.75456303
116MP0000490_abnormal_crypts_of0.74323326
117MP0005257_abnormal_intraocular_pressure0.73790292
118MP0005408_hypopigmentation0.72709233
119MP0005166_decreased_susceptibility_to0.71951366
120MP0000733_abnormal_muscle_development0.71426065
121* MP0005584_abnormal_enzyme/coenzyme_acti0.70981274
122MP0003075_altered_response_to0.68267674
123MP0003866_abnormal_defecation0.67639404
124MP0005165_increased_susceptibility_to0.66494653

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.62259080
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.62259080
3Abnormality of glycolipid metabolism (HP:0010969)5.62259080
4Recurrent abscess formation (HP:0002722)4.36854112
5Eczematoid dermatitis (HP:0000976)4.20099475
6Recurrent bacterial skin infections (HP:0005406)3.96180773
7Hematochezia (HP:0002573)3.94772533
8Spontaneous hematomas (HP:0007420)3.43683356
9Myositis (HP:0100614)3.35377185
10Systemic lupus erythematosus (HP:0002725)3.34591562
11Elevated erythrocyte sedimentation rate (HP:0003565)3.20354056
12Recurrent gram-negative bacterial infections (HP:0005420)3.19652192
13Keratoconjunctivitis sicca (HP:0001097)3.10384626
14Recurrent fungal infections (HP:0002841)3.07764720
15Loss of speech (HP:0002371)3.06528585
16Recurrent viral infections (HP:0004429)3.01533502
17Gastrointestinal infarctions (HP:0005244)3.00205394
18Keratoconjunctivitis (HP:0001096)2.90737559
19Pustule (HP:0200039)2.89264962
20Mediastinal lymphadenopathy (HP:0100721)2.86594711
21Myocardial infarction (HP:0001658)2.85261331
22Gingivitis (HP:0000230)2.81685816
23Increased cerebral lipofuscin (HP:0011813)2.77869205
24Periodontitis (HP:0000704)2.75318184
25Cerebral aneurysm (HP:0004944)2.71336394
26Orchitis (HP:0100796)2.71074300
27Stomatitis (HP:0010280)2.69483185
28Recurrent skin infections (HP:0001581)2.66132356
29Glomerulonephritis (HP:0000099)2.64677797
30Abnormality of macrophages (HP:0004311)2.63623844
31Chronic otitis media (HP:0000389)2.61024431
32Autoimmune thrombocytopenia (HP:0001973)2.50834412
33Vacuolated lymphocytes (HP:0001922)2.46976201
34Arterial thrombosis (HP:0004420)2.40313385
35Retrobulbar optic neuritis (HP:0100654)2.40195071
36Optic neuritis (HP:0100653)2.40195071
37Encephalitis (HP:0002383)2.39926960
38T lymphocytopenia (HP:0005403)2.39252489
39Syringomyelia (HP:0003396)2.38530971
40Spinal cord lesions (HP:0100561)2.38530971
41Increased neuronal autofluorescent lipopigment (HP:0002074)2.37925423
42Abnormality of T cell number (HP:0011839)2.37468962
43Amyloidosis (HP:0011034)2.36492139
44Neurofibrillary tangles (HP:0002185)2.36298549
45Complement deficiency (HP:0004431)2.35117686
46Subacute progressive viral hepatitis (HP:0006572)2.34751399
47Cellulitis (HP:0100658)2.31482402
48Colitis (HP:0002583)2.31276547
49Inflammation of the large intestine (HP:0002037)2.30825913
50Recurrent bronchitis (HP:0002837)2.29455328
51Pulmonary embolism (HP:0002204)2.29398016
52Pulmonary infiltrates (HP:0002113)2.28766065
53Eosinophilia (HP:0001880)2.28293493
54Recurrent cutaneous fungal infections (HP:0011370)2.28280710
55Chronic mucocutaneous candidiasis (HP:0002728)2.28280710
56Gastrointestinal inflammation (HP:0004386)2.26476528
57Mutism (HP:0002300)2.26277380
58Aortic aneurysm (HP:0004942)2.26180053
59Leukocytosis (HP:0001974)2.25449646
60Chest pain (HP:0100749)2.25255337
61Hyperacusis (HP:0010780)2.21934138
62Spondylolisthesis (HP:0003302)2.20343997
63Vasculitis (HP:0002633)2.16305998
64Progressive neurologic deterioration (HP:0002344)2.15424936
65Nasal polyposis (HP:0100582)2.13702074
66Gangrene (HP:0100758)2.12107497
67Meningitis (HP:0001287)2.11902287
68Interstitial pulmonary disease (HP:0006530)2.11810097
69Abnormality of the nasal mucosa (HP:0000433)2.11210844
70Mitral stenosis (HP:0001718)2.11153689
71Aortic dissection (HP:0002647)2.08996980
72Thyroiditis (HP:0100646)2.07677465
73Abnormality of the vasculature of the conjunctiva (HP:0008054)2.07092026
74Osteomyelitis (HP:0002754)2.07010885
75Abnormality of the pleura (HP:0002103)2.06827075
76Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06187087
77Short 4th metacarpal (HP:0010044)2.06187087
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.05939284
79Osteolytic defects of the hand bones (HP:0009699)2.05939284
80Absent frontal sinuses (HP:0002688)2.04442169
81Dysostosis multiplex (HP:0000943)2.02650050
82Abnormal delayed hypersensitivity skin test (HP:0002963)2.02185261
83Abnormality of complement system (HP:0005339)2.01911949
84Gingival bleeding (HP:0000225)2.00656456
85Abnormality of T cells (HP:0002843)2.00522798
86Prostate neoplasm (HP:0100787)1.99713085
87Increased CSF protein (HP:0002922)1.98173601
88Nephritis (HP:0000123)1.98018727
89Joint hemorrhage (HP:0005261)1.97777006
90Fatigue (HP:0012378)1.97457985
91Disinhibition (HP:0000734)1.96932108
92Panhypogammaglobulinemia (HP:0003139)1.95837091
93Peritonitis (HP:0002586)1.95666494
94Cerebral inclusion bodies (HP:0100314)1.95229710
95Anorexia (HP:0002039)1.91262157
96Abnormality of the pericardium (HP:0001697)1.91116091
97Esophageal varix (HP:0002040)1.91070959
98Purpura (HP:0000979)1.90354131
99Episodic fever (HP:0001954)1.89928915
100Polyneuropathy (HP:0001271)1.89867186
101Increased IgM level (HP:0003496)1.89821657
102Abnormality of the fingertips (HP:0001211)1.88757303
103Abnormality of eosinophils (HP:0001879)1.88086969
104Abnormality of the endocardium (HP:0004306)1.87531063
105Mucopolysacchariduria (HP:0008155)1.86428502
106Urinary glycosaminoglycan excretion (HP:0003541)1.86428502
107Apathy (HP:0000741)1.86403941
108Thick nail (HP:0001805)1.86134878
109IgM deficiency (HP:0002850)1.86125932
110Joint swelling (HP:0001386)1.86042942
111Obstructive lung disease (HP:0006536)1.85829860
112Chronic obstructive pulmonary disease (HP:0006510)1.85829860
113Disproportionate tall stature (HP:0001519)1.84593105
114Acne (HP:0001061)1.83340053
115Hypergammaglobulinemia (HP:0010702)1.83253593
116Increased serum ferritin (HP:0003281)1.83181431
117Granulocytopenia (HP:0001913)1.82935500
118Diminished motivation (HP:0000745)1.81930683
119Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81454990
120Abnormality of polysaccharide metabolism (HP:0011012)1.81454990
121Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81454990
122Mitral valve prolapse (HP:0001634)1.80993610
123Severe combined immunodeficiency (HP:0004430)1.79412537
124Axonal loss (HP:0003447)1.78426933
125Bicuspid aortic valve (HP:0001647)1.78389083
126Emphysema (HP:0002097)1.78117722
127Hypoplasia of the thymus (HP:0000778)1.77205726
128Agammaglobulinemia (HP:0004432)1.76846175
129Arterial tortuosity (HP:0005116)1.76685671
130Glomerulopathy (HP:0100820)1.75742675
131Hemoptysis (HP:0002105)1.75434356
132Lymphopenia (HP:0001888)1.75299257
133Urticaria (HP:0001025)1.74932120
134Vertebral compression fractures (HP:0002953)1.74383077
135Cerebral hemorrhage (HP:0001342)1.74375284
136Abnormality of the peritoneum (HP:0002585)1.73999471
137Steatorrhea (HP:0002570)1.73230821
138Polycythemia (HP:0001901)1.73042400
139Cheilitis (HP:0100825)1.71877458
140Hepatosplenomegaly (HP:0001433)1.71805187

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.40426128
2MAP3K143.11614868
3* TYK22.70860414
4NEK12.60591503
5TBK12.46958234
6TXK2.42989632
7TGFBR22.37106884
8IKBKE2.33191539
9JAK12.22704370
10JAK32.17843473
11FGFR42.17728111
12ERN12.06944451
13KIT2.04621470
14IRAK42.00449873
15BLK1.88763742
16STK101.88696976
17CAMKK21.86517957
18ZAP701.85572406
19MAP3K101.81799687
20FGFR31.69459205
21BMPR21.67354236
22IRAK11.65725256
23CDK121.64434893
24FGR1.63886953
25ITK1.63705675
26EPHA31.62362557
27TRIB31.61977236
28IKBKB1.59865059
29EPHB11.57670040
30CSK1.57364975
31ACVR1B1.56976385
32EEF2K1.54249960
33PKN21.53868567
34CHUK1.50471317
35PTK61.49597643
36PDGFRA1.46796614
37CAMK1D1.40562745
38TTN1.35948805
39* HCK1.33139332
40SIK21.29145434
41LCK1.27900388
42BTK1.27117932
43CSF1R1.23509087
44IRAK31.22054934
45AKT31.19048356
46TAOK11.17348365
47SIK11.16782171
48MAP3K21.16302212
49GRK61.15126536
50RIPK11.14492579
51MAP2K31.12463005
52MARK31.11912131
53PDGFRB1.11251765
54SYK1.10409571
55JAK21.10383349
56PIM11.07301179
57TEC1.04773985
58CDK61.04769726
59RPS6KA41.00448886
60CLK11.00259250
61PRPF4B0.99005574
62KDR0.96883437
63LRRK20.96837790
64NEK90.95034280
65TNK20.93996673
66MAP3K10.93514461
67IRAK20.87966863
68RIPK40.87112292
69SCYL20.86318907
70KSR20.85771869
71CAMK1G0.84814901
72LYN0.84146345
73DDR20.82907095
74MAP3K120.81627658
75FLT30.80278182
76NLK0.80024664
77MOS0.78358563
78MAP3K130.77598383
79MAP3K110.75196330
80CDC42BPA0.74918574
81SGK20.74137815
82FER0.73463545
83STK30.73154163
84PAK40.71274169
85STK40.70926989
86KSR10.68468998
87TAOK20.67246412
88MAP3K50.67122448
89BRD40.67021255
90TGFBR10.66753780
91EGFR0.66498403
92MAP3K60.63330032
93MAP3K30.63078030
94YES10.61860708
95FES0.59641352
96SGK30.57560498
97MAPK110.55845126
98ABL10.55569563
99PDK10.55516842
100STK380.54970115
101DYRK1B0.54370427
102PRKCH0.54367042
103PIK3CG0.52197298
104CDK40.51880448
105PRKCQ0.51224003
106ALK0.50604233
107PAK30.50501610
108CDK90.50327856
109ROCK20.50277172
110MTOR0.49622720
111INSR0.48288238
112GRK70.47719116
113TRPM70.46432341
114ADRBK20.46283890
115PTK2B0.44776364
116PDPK10.44083409
117FYN0.42151477
118TAOK30.40039223
119FRK0.39671679
120SIK30.39456105
121FGFR20.39351123
122CAMK40.38980791
123MAPK70.38856371
124PRKD20.38525281
125GSK3A0.38104643
126EPHB20.37979497
127MATK0.37745208
128CAMKK10.36686794
129* IGF1R0.36477618
130PTK20.35918619
131MELK0.35754119
132RET0.34336916
133LATS10.34274440
134BMX0.33390934
135MAPKAPK20.32323891
136EIF2AK20.32211562
137RPS6KA60.31448816
138MAPK120.29887375
139MAPK40.28729251
140PRKD10.27371748

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.71807155
2Staphylococcus aureus infection_Homo sapiens_hsa051502.67426411
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.46204688
4* Osteoclast differentiation_Homo sapiens_hsa043802.32825958
5Primary immunodeficiency_Homo sapiens_hsa053402.29751710
6* Measles_Homo sapiens_hsa051622.05263961
7* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.02588903
8B cell receptor signaling pathway_Homo sapiens_hsa046622.02076691
9Toxoplasmosis_Homo sapiens_hsa051451.91185986
10Antigen processing and presentation_Homo sapiens_hsa046121.79584702
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78419144
12T cell receptor signaling pathway_Homo sapiens_hsa046601.73187383
13* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72547289
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.70429935
15Graft-versus-host disease_Homo sapiens_hsa053321.67299501
16Viral myocarditis_Homo sapiens_hsa054161.64381370
17Pertussis_Homo sapiens_hsa051331.63495237
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.55643989
19Malaria_Homo sapiens_hsa051441.53477695
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.51748807
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50096681
22TNF signaling pathway_Homo sapiens_hsa046681.49934302
23Chronic myeloid leukemia_Homo sapiens_hsa052201.49363932
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46896479
25Tuberculosis_Homo sapiens_hsa051521.46366902
26Hematopoietic cell lineage_Homo sapiens_hsa046401.45626250
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40501005
28Legionellosis_Homo sapiens_hsa051341.39278149
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37487400
30Apoptosis_Homo sapiens_hsa042101.35332258
31* Influenza A_Homo sapiens_hsa051641.34689921
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32613785
33Chemokine signaling pathway_Homo sapiens_hsa040621.30612962
34* Herpes simplex infection_Homo sapiens_hsa051681.30608917
35* Jak-STAT signaling pathway_Homo sapiens_hsa046301.28222913
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.27696178
37Allograft rejection_Homo sapiens_hsa053301.26187154
38* Hepatitis B_Homo sapiens_hsa051611.26007818
39Complement and coagulation cascades_Homo sapiens_hsa046101.24257820
40Type I diabetes mellitus_Homo sapiens_hsa049401.22919308
41Small cell lung cancer_Homo sapiens_hsa052221.22502191
42Shigellosis_Homo sapiens_hsa051311.21542396
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21318311
44Pancreatic cancer_Homo sapiens_hsa052121.19832156
45Lysosome_Homo sapiens_hsa041421.18962540
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16794481
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.14054839
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13063831
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10219761
50Other glycan degradation_Homo sapiens_hsa005111.09260611
51Acute myeloid leukemia_Homo sapiens_hsa052211.08172584
52Caffeine metabolism_Homo sapiens_hsa002321.06751504
53* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00691351
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.00200169
55Salmonella infection_Homo sapiens_hsa051320.99818023
56* Hepatitis C_Homo sapiens_hsa051600.98706813
57Notch signaling pathway_Homo sapiens_hsa043300.95345099
58Proteoglycans in cancer_Homo sapiens_hsa052050.95109355
59Prolactin signaling pathway_Homo sapiens_hsa049170.92490750
60HTLV-I infection_Homo sapiens_hsa051660.91866200
61MicroRNAs in cancer_Homo sapiens_hsa052060.90077132
62Adherens junction_Homo sapiens_hsa045200.89652525
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88824831
64Platelet activation_Homo sapiens_hsa046110.88734164
65Focal adhesion_Homo sapiens_hsa045100.84825805
66Phagosome_Homo sapiens_hsa041450.82930719
67Amoebiasis_Homo sapiens_hsa051460.81799800
68Lysine degradation_Homo sapiens_hsa003100.80409289
69Viral carcinogenesis_Homo sapiens_hsa052030.76658410
70Sphingolipid metabolism_Homo sapiens_hsa006000.76499097
71Colorectal cancer_Homo sapiens_hsa052100.74895040
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74440403
73Insulin resistance_Homo sapiens_hsa049310.74385283
74PPAR signaling pathway_Homo sapiens_hsa033200.73393965
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.73211938
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71803864
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71249772
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71228159
79Asthma_Homo sapiens_hsa053100.70683233
80ECM-receptor interaction_Homo sapiens_hsa045120.67520554
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.67029179
82Collecting duct acid secretion_Homo sapiens_hsa049660.65197726
83Non-small cell lung cancer_Homo sapiens_hsa052230.64847543
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63386796
85Endometrial cancer_Homo sapiens_hsa052130.62338663
86FoxO signaling pathway_Homo sapiens_hsa040680.62230906
87Prostate cancer_Homo sapiens_hsa052150.62127688
88VEGF signaling pathway_Homo sapiens_hsa043700.61713626
89Rheumatoid arthritis_Homo sapiens_hsa053230.58079218
90Endocytosis_Homo sapiens_hsa041440.58056268
91Autoimmune thyroid disease_Homo sapiens_hsa053200.55836677
92Dorso-ventral axis formation_Homo sapiens_hsa043200.52978793
93African trypanosomiasis_Homo sapiens_hsa051430.51492634
94Epstein-Barr virus infection_Homo sapiens_hsa051690.51177299
95p53 signaling pathway_Homo sapiens_hsa041150.50719759
96HIF-1 signaling pathway_Homo sapiens_hsa040660.50514464
97mTOR signaling pathway_Homo sapiens_hsa041500.50075885
98Pathways in cancer_Homo sapiens_hsa052000.49755479
99Glioma_Homo sapiens_hsa052140.46448210
100Rap1 signaling pathway_Homo sapiens_hsa040150.45498711
101Prion diseases_Homo sapiens_hsa050200.45128784
102ABC transporters_Homo sapiens_hsa020100.44763672
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43868548
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.43309257
105Vibrio cholerae infection_Homo sapiens_hsa051100.43284459
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43197322
107Renal cell carcinoma_Homo sapiens_hsa052110.42302294
108Renin-angiotensin system_Homo sapiens_hsa046140.41949683
109Systemic lupus erythematosus_Homo sapiens_hsa053220.41591931
110Sulfur metabolism_Homo sapiens_hsa009200.40436486
111Mineral absorption_Homo sapiens_hsa049780.37898098
112* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37236269
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37147148
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36780513
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36262307
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.36166362
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34207870
118GnRH signaling pathway_Homo sapiens_hsa049120.32269747
119Histidine metabolism_Homo sapiens_hsa003400.30366347
120Fatty acid degradation_Homo sapiens_hsa000710.28786475
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28502158
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28023954
123Chemical carcinogenesis_Homo sapiens_hsa052040.27590605
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26581645
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25060528

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