IFNAR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.27011268
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.27011268
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.95814171
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.95814171
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.69571751
6antigen processing and presentation of endogenous antigen (GO:0019883)4.34921312
7detection of other organism (GO:0098543)4.29401727
8detection of bacterium (GO:0016045)4.08064542
9positive regulation by symbiont of host defense response (GO:0052509)4.05988747
10modulation by symbiont of host defense response (GO:0052031)4.05988747
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.05988747
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.05988747
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.05988747
14modulation by symbiont of host immune response (GO:0052553)4.05988747
15regulation of interferon-beta biosynthetic process (GO:0045357)3.79250631
16detection of external biotic stimulus (GO:0098581)3.76923363
17positive regulation of interferon-alpha production (GO:0032727)3.74968997
18positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.68374936
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.65818186
20positive regulation of gamma-delta T cell activation (GO:0046645)3.65117002
21regulation of interferon-alpha production (GO:0032647)3.54391789
22negative regulation of T cell mediated immunity (GO:0002710)3.48469312
23negative regulation of lymphocyte mediated immunity (GO:0002707)3.48075512
24regulation of dendritic cell antigen processing and presentation (GO:0002604)3.43943444
25T cell migration (GO:0072678)3.42948007
26leukocyte aggregation (GO:0070486)3.41680116
27response to peptidoglycan (GO:0032494)3.41413696
28neutrophil activation involved in immune response (GO:0002283)3.39377146
29germinal center formation (GO:0002467)3.39371526
30negative thymic T cell selection (GO:0045060)3.38597923
31B cell receptor signaling pathway (GO:0050853)3.38211602
32positive regulation of B cell differentiation (GO:0045579)3.37977317
33detection of biotic stimulus (GO:0009595)3.33130418
34response to interleukin-15 (GO:0070672)3.31101134
35negative T cell selection (GO:0043383)3.30789588
36immunoglobulin mediated immune response (GO:0016064)3.29669690
37regulation of mast cell degranulation (GO:0043304)3.28325862
38macrophage activation (GO:0042116)3.24678162
39negative regulation of leukocyte mediated immunity (GO:0002704)3.16886333
40regulation of antigen processing and presentation (GO:0002577)3.16563207
41regulation of T cell tolerance induction (GO:0002664)3.16540647
42regulation of B cell receptor signaling pathway (GO:0050855)3.14910907
43macrophage activation involved in immune response (GO:0002281)3.14567800
44positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.09646884
45complement activation, alternative pathway (GO:0006957)3.09497683
46positive regulation of mast cell activation (GO:0033005)3.08746661
47cellular response to interleukin-15 (GO:0071350)3.07692014
48regulation of alpha-beta T cell proliferation (GO:0046640)3.07529717
49response to muramyl dipeptide (GO:0032495)3.06502246
50regulation of tolerance induction (GO:0002643)3.06260699
51regulation of T cell mediated cytotoxicity (GO:0001914)3.06136670
52respiratory burst (GO:0045730)3.04463206
53positive thymic T cell selection (GO:0045059)3.03489314
54tolerance induction (GO:0002507)3.03068803
55regulation of mast cell activation (GO:0033003)3.02611305
56regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.01241655
57regulation of mast cell activation involved in immune response (GO:0033006)3.00105868
58T-helper 1 type immune response (GO:0042088)2.97665698
59* response to type I interferon (GO:0034340)2.97282174
60regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.96322635
61* cellular response to type I interferon (GO:0071357)2.95405033
62* type I interferon signaling pathway (GO:0060337)2.95405033
63positive regulation of T cell mediated cytotoxicity (GO:0001916)2.92978169
64response to interferon-beta (GO:0035456)2.92473592
65negative regulation of interleukin-12 production (GO:0032695)2.89065836
66positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.86838045
67NIK/NF-kappaB signaling (GO:0038061)2.86065315
68antigen processing and presentation via MHC class Ib (GO:0002475)2.86015705
69regulation of interleukin-12 production (GO:0032655)2.85890160
70positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85466427
71regulation of myeloid leukocyte mediated immunity (GO:0002886)2.85027018
72positive regulation of interleukin-17 production (GO:0032740)2.84719260
73positive regulation of type 2 immune response (GO:0002830)2.84417848
74defense response to protozoan (GO:0042832)2.83594103
75disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.83348794
76killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.83348794
77negative regulation of cytokine production involved in immune response (GO:0002719)2.81702338
78positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.81668293
79T cell selection (GO:0045058)2.81637577
80positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.81392050
81triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.79160563
82regulation of leukocyte degranulation (GO:0043300)2.78154770
83regulation of T-helper 1 cell differentiation (GO:0045625)2.77774859
84positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.77435370
85Arp2/3 complex-mediated actin nucleation (GO:0034314)2.77191405
86lipopolysaccharide-mediated signaling pathway (GO:0031663)2.77026214
87myeloid dendritic cell differentiation (GO:0043011)2.77007372
88leukocyte degranulation (GO:0043299)2.76860736
89detection of molecule of bacterial origin (GO:0032490)2.76447102
90peptidyl-glutamic acid carboxylation (GO:0017187)2.75958514
91protein carboxylation (GO:0018214)2.75958514
92response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.73841224
93response to host immune response (GO:0052572)2.73841224
94regulation of B cell differentiation (GO:0045577)2.73638027
95regulation of interleukin-12 biosynthetic process (GO:0045075)2.70264361
96response to protozoan (GO:0001562)2.69366246
97fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.65374455
98pinocytosis (GO:0006907)2.65262264
99regulation of protein activation cascade (GO:2000257)2.64627726
100* response to interferon-alpha (GO:0035455)2.64070368
101negative regulation of phagocytosis (GO:0050765)2.63474881
102alpha-linolenic acid metabolic process (GO:0036109)2.62374332
103regulation of gamma-delta T cell differentiation (GO:0045586)2.61121450
104reactive oxygen species biosynthetic process (GO:1903409)2.59569410
105positive regulation of interferon-beta production (GO:0032728)2.58007110
106regulation of complement activation (GO:0030449)2.57568988
107negative regulation of granulocyte differentiation (GO:0030853)2.57374672
108B cell mediated immunity (GO:0019724)2.56573290
109modulation of growth of symbiont involved in interaction with host (GO:0044144)2.56381895
110regulation of growth of symbiont in host (GO:0044126)2.56381895
111negative regulation of growth of symbiont in host (GO:0044130)2.56381895
112negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.56381895
113cellular extravasation (GO:0045123)2.55263731
114regulation of gamma-delta T cell activation (GO:0046643)2.54571286
115regulation of cholesterol storage (GO:0010885)2.54541581
116response to host defenses (GO:0052200)2.53756610
117response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.53756610
118response to host (GO:0075136)2.53756610
119plasma lipoprotein particle clearance (GO:0034381)2.52835178
120production of molecular mediator involved in inflammatory response (GO:0002532)2.52691405
121positive regulation of antigen processing and presentation (GO:0002579)2.52179674
122myeloid cell activation involved in immune response (GO:0002275)2.50975841
123interferon-gamma-mediated signaling pathway (GO:0060333)2.50416841
124tryptophan catabolic process (GO:0006569)2.48794244
125indole-containing compound catabolic process (GO:0042436)2.48794244
126indolalkylamine catabolic process (GO:0046218)2.48794244
127neutrophil activation (GO:0042119)2.47935681
128cellular response to exogenous dsRNA (GO:0071360)2.47285628
129cellular response to interferon-beta (GO:0035458)2.46686706
130tryptophan metabolic process (GO:0006568)2.46572993
131mast cell activation (GO:0045576)2.44685154
132hydrogen peroxide biosynthetic process (GO:0050665)2.41945477
133aromatic amino acid family catabolic process (GO:0009074)2.40608764
134positive regulation of natural killer cell differentiation (GO:0032825)2.40124343
135granulocyte activation (GO:0036230)2.39014119
136neutrophil mediated immunity (GO:0002446)2.38905535
137phospholipid efflux (GO:0033700)2.38534235
138angiogenesis involved in wound healing (GO:0060055)2.36879348
139positive regulation of macrophage differentiation (GO:0045651)2.35769906
140negative regulation of myeloid cell apoptotic process (GO:0033033)2.35484989
141positive regulation of coagulation (GO:0050820)2.34452489
142negative regulation of erythrocyte differentiation (GO:0045647)2.34291551
143microglial cell activation (GO:0001774)2.33841021
144valine metabolic process (GO:0006573)2.33794492
145complement activation (GO:0006956)2.33583530
146regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.31694784
147negative regulation of interleukin-17 production (GO:0032700)2.31652094
148opsonization (GO:0008228)2.31645760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.95185261
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.31400636
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.07095899
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.06817133
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.22726353
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.21567728
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.07487653
8* RXR_22158963_ChIP-Seq_LIVER_Mouse3.07300987
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04707632
10* IRF8_27001747_Chip-Seq_BMDM_Mouse3.04308517
11* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93298324
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.90524448
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.90046455
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.79991997
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78347132
16GATA1_22025678_ChIP-Seq_K562_Human2.78078717
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.76838920
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.71223826
19* SCL_19346495_ChIP-Seq_HPC-7_Human2.62573012
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.51604127
21* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.40413782
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35882471
23LXR_22158963_ChIP-Seq_LIVER_Mouse2.28659864
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.26133970
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.24238877
26* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.14632759
27* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.14415468
28VDR_21846776_ChIP-Seq_THP-1_Human2.05962325
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05272228
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.00541701
31SPI1_23547873_ChIP-Seq_NB4_Human2.00318175
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.97637203
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96106406
34* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94650540
35* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89900359
36VDR_24763502_ChIP-Seq_THP-1_Human1.87194908
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.83547359
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.77893626
39* MAF_26560356_Chip-Seq_TH1_Human1.76987439
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76557268
41* MYB_26560356_Chip-Seq_TH2_Human1.75888943
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75778682
43RUNX_20019798_ChIP-Seq_JUKART_Human1.71858276
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67036945
45FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.65872721
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.65017984
47* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63904798
48MYC_22102868_ChIP-Seq_BL_Human1.57108698
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.56537537
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54908613
51* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54734460
52* MYB_26560356_Chip-Seq_TH1_Human1.54702313
53* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53691252
54E2F7_22180533_ChIP-Seq_HELA_Human1.53618391
55* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50756603
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.49792475
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47174106
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46292559
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45527105
60PU_27001747_Chip-Seq_BMDM_Mouse1.43528017
61SPI1_23127762_ChIP-Seq_K562_Human1.42980748
62* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41018546
63UTX_26944678_Chip-Seq_JUKART_Human1.38502993
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37827627
65* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37583369
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35917294
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31728511
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31563576
69KDM2B_26808549_Chip-Seq_DND41_Human1.29487179
70* TCF7_22412390_ChIP-Seq_EML_Mouse1.28269336
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27978669
72* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27337872
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24021083
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.23192540
75* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22525759
76* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22231653
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.21052588
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.18743229
79* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13552788
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13531915
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13471950
82NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11887817
83CLOCK_20551151_ChIP-Seq_293T_Human1.11729527
84GATA3_27048872_Chip-Seq_THYMUS_Human1.09048173
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08889116
86ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07492230
87CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06273191
88RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05836442
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05739765
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05689262
91GATA1_19941826_ChIP-Seq_K562_Human1.04901720
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04824679
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04129641
94MAF_26560356_Chip-Seq_TH2_Human1.03506057
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.03314100
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02358359
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02293978
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02119621
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00274524
100* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99717644
101* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99488620
102BCL6_27268052_Chip-Seq_Bcells_Human0.96998641
103PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96654894
104GATA2_19941826_ChIP-Seq_K562_Human0.95146247
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94808474
106IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93588449
107* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92953615
108VDR_24787735_ChIP-Seq_THP-1_Human0.92893597
109* GATA3_26560356_Chip-Seq_TH2_Human0.90783025
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89276338
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88637186
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87124321
113SPI1_20517297_ChIP-Seq_HL60_Human0.85406755
114BCOR_27268052_Chip-Seq_Bcells_Human0.85070214
115STAT1_20625510_ChIP-Seq_HELA_Human0.83618412
116LXR_22292898_ChIP-Seq_THP-1_Human0.83343904
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82955592
118SMRT_27268052_Chip-Seq_Bcells_Human0.79768736
119TFEB_21752829_ChIP-Seq_HELA_Human0.79456381
120NCOR1_26117541_ChIP-Seq_K562_Human0.79219702
121KDM2B_26808549_Chip-Seq_JURKAT_Human0.77426836
122RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76599378

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.35325543
2MP0003724_increased_susceptibility_to2.92683695
3MP0003436_decreased_susceptibility_to2.91172187
4MP0009785_altered_susceptibility_to2.78359048
5MP0003303_peritoneal_inflammation2.54739074
6MP0002139_abnormal_hepatobiliary_system2.50408815
7MP0003191_abnormal_cellular_cholesterol2.49070393
8* MP0002419_abnormal_innate_immunity2.46164823
9MP0005360_urolithiasis2.38412649
10* MP0005025_abnormal_response_to2.35008405
11MP0000685_abnormal_immune_system2.34607664
12MP0005365_abnormal_bile_salt2.28814793
13MP0005464_abnormal_platelet_physiology2.27418011
14MP0009840_abnormal_foam_cell2.23786134
15MP0002148_abnormal_hypersensitivity_rea2.19585250
16MP0005058_abnormal_lysosome_morphology2.19227541
17MP0005000_abnormal_immune_tolerance2.18574320
18MP0005671_abnormal_response_to2.10343705
19MP0002396_abnormal_hematopoietic_system2.06883874
20* MP0001800_abnormal_humoral_immune2.04119672
21MP0005387_immune_system_phenotype2.03067827
22MP0001790_abnormal_immune_system2.03067827
23* MP0002452_abnormal_antigen_presenting2.00016740
24* MP0002723_abnormal_immune_serum1.96157479
25MP0005085_abnormal_gallbladder_physiolo1.95437189
26MP0002166_altered_tumor_susceptibility1.93525542
27MP0006082_CNS_inflammation1.92884027
28MP0008875_abnormal_xenobiotic_pharmacok1.82319848
29* MP0002420_abnormal_adaptive_immunity1.79357085
30MP0003300_gastrointestinal_ulcer1.79033614
31* MP0001819_abnormal_immune_cell1.78480923
32MP0001853_heart_inflammation1.75627313
33MP0008469_abnormal_protein_level1.75460740
34MP0005397_hematopoietic_system_phenotyp1.71194366
35MP0001545_abnormal_hematopoietic_system1.71194366
36MP0001533_abnormal_skeleton_physiology1.69435455
37MP0001845_abnormal_inflammatory_respons1.67504597
38MP0002405_respiratory_system_inflammati1.59052741
39MP0010329_abnormal_lipoprotein_level1.58457338
40MP0009764_decreased_sensitivity_to1.58023724
41MP0002006_tumorigenesis1.56595717
42MP0010155_abnormal_intestine_physiology1.53586258
43MP0003252_abnormal_bile_duct1.53041861
44MP0003656_abnormal_erythrocyte_physiolo1.52414402
45MP0000343_altered_response_to1.50704652
46MP0005451_abnormal_body_composition1.48150665
47MP0002398_abnormal_bone_marrow1.47930558
48MP0005310_abnormal_salivary_gland1.47099737
49MP0000689_abnormal_spleen_morphology1.44846100
50* MP0000716_abnormal_immune_system1.44348259
51MP0009278_abnormal_bone_marrow1.41655785
52MP0000609_abnormal_liver_physiology1.39104947
53MP0003186_abnormal_redox_activity1.38802837
54MP0004947_skin_inflammation1.35558499
55MP0008260_abnormal_autophagy1.34899281
56MP0006054_spinal_hemorrhage1.33712208
57MP0003763_abnormal_thymus_physiology1.28734481
58MP0002722_abnormal_immune_system1.28655204
59MP0009763_increased_sensitivity_to1.27747456
60* MP0002429_abnormal_blood_cell1.27150666
61MP0004808_abnormal_hematopoietic_stem1.26086403
62MP0000703_abnormal_thymus_morphology1.25090463
63MP0009333_abnormal_splenocyte_physiolog1.24886473
64MP0008438_abnormal_cutaneous_collagen1.24638046
65MP0005083_abnormal_biliary_tract1.23586580
66MP0003172_abnormal_lysosome_physiology1.22005980
67MP0003183_abnormal_peptide_metabolism1.21328070
68MP0000465_gastrointestinal_hemorrhage1.19062025
69MP0005319_abnormal_enzyme/_coenzyme1.18129519
70MP0003806_abnormal_nucleotide_metabolis1.17679046
71MP0000858_altered_metastatic_potential1.17598622
72MP0003075_altered_response_to1.17462983
73MP0002132_abnormal_respiratory_system1.12291022
74MP0001873_stomach_inflammation1.08331745
75MP0010368_abnormal_lymphatic_system1.04874551
76MP0002933_joint_inflammation1.04629136
77MP0002998_abnormal_bone_remodeling1.03951519
78MP0003448_altered_tumor_morphology1.03947626
79MP0004883_abnormal_blood_vessel1.03494280
80MP0005584_abnormal_enzyme/coenzyme_acti1.02844593
81MP0000598_abnormal_liver_morphology1.01239170
82MP0000249_abnormal_blood_vessel1.01098077
83MP0002277_abnormal_respiratory_mucosa1.00597492
84MP0003690_abnormal_glial_cell1.00397003
85MP0002138_abnormal_hepatobiliary_system1.00231426
86MP0008004_abnormal_stomach_pH0.99936483
87MP0004510_myositis0.97309074
88MP0004381_abnormal_hair_follicle0.94992371
89MP0005023_abnormal_wound_healing0.94644090
90MP0003828_pulmonary_edema0.92872716
91MP0001663_abnormal_digestive_system0.89429419
92MP0005164_abnormal_response_to0.89391745
93MP0002118_abnormal_lipid_homeostasis0.89377338
94MP0005075_abnormal_melanosome_morpholog0.88909468
95MP0005174_abnormal_tail_pigmentation0.87246101
96MP0003195_calcinosis0.86089045
97MP0003279_aneurysm0.85858902
98MP0009697_abnormal_copulation0.85305237
99MP0000604_amyloidosis0.84365963
100MP0005167_abnormal_blood-brain_barrier0.84113300
101MP0000371_diluted_coat_color0.83716706
102MP0009643_abnormal_urine_homeostasis0.83286968
103MP0005166_decreased_susceptibility_to0.82934429
104MP0001879_abnormal_lymphatic_vessel0.82680898
105MP0005390_skeleton_phenotype0.79133063
106MP0000490_abnormal_crypts_of0.78885202
107MP0005332_abnormal_amino_acid0.78553937
108MP0001666_abnormal_nutrient_absorption0.77569392
109MP0001851_eye_inflammation0.77140721
110MP0002254_reproductive_system_inflammat0.76268295
111MP0003866_abnormal_defecation0.74794914
112MP0002136_abnormal_kidney_physiology0.74360731
113MP0004147_increased_porphyrin_level0.73995877
114MP0003045_fibrosis0.71427375
115MP0009765_abnormal_xenobiotic_induced0.70473977
116MP0003795_abnormal_bone_structure0.65592952
117MP0000015_abnormal_ear_pigmentation0.58891071
118MP0002009_preneoplasia0.57598148
119MP0002332_abnormal_exercise_endurance0.55602553
120MP0003091_abnormal_cell_migration0.54825479
121MP0008874_decreased_physiological_sensi0.54010969
122MP0002693_abnormal_pancreas_physiology0.53377293
123MP0003453_abnormal_keratinocyte_physiol0.48817565

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.80696553
2Recurrent bacterial skin infections (HP:0005406)4.66027869
3Systemic lupus erythematosus (HP:0002725)4.36360983
4Eczematoid dermatitis (HP:0000976)4.31364074
5Recurrent gram-negative bacterial infections (HP:0005420)4.24345635
6Elevated erythrocyte sedimentation rate (HP:0003565)4.01894408
7Myositis (HP:0100614)3.92295921
8Keratoconjunctivitis sicca (HP:0001097)3.91871411
9Complement deficiency (HP:0004431)3.84859634
10Keratoconjunctivitis (HP:0001096)3.61819244
11Encephalitis (HP:0002383)3.57227875
12Abnormality of liposaccharide metabolism (HP:0010968)3.57067334
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.57067334
14Abnormality of glycolipid metabolism (HP:0010969)3.57067334
15Glomerulonephritis (HP:0000099)3.50725956
16T lymphocytopenia (HP:0005403)3.45806418
17Recurrent skin infections (HP:0001581)3.39458174
18Joint hemorrhage (HP:0005261)3.38725213
19Abnormality of T cell number (HP:0011839)3.38589587
20Vacuolated lymphocytes (HP:0001922)3.36570277
21Prolonged partial thromboplastin time (HP:0003645)3.26551052
22Spontaneous hematomas (HP:0007420)3.24868684
23Abnormality of complement system (HP:0005339)3.23660287
24Chronic otitis media (HP:0000389)3.20983138
25Abnormality of macrophages (HP:0004311)3.09575735
26Thrombocytosis (HP:0001894)3.09186729
27Deep venous thrombosis (HP:0002625)3.01059353
28Increased IgE level (HP:0003212)3.00962144
29Recurrent viral infections (HP:0004429)2.95203721
30Autoimmune thrombocytopenia (HP:0001973)2.92189122
31Leukocytosis (HP:0001974)2.89281223
32Recurrent fungal infections (HP:0002841)2.87763787
33Gingival bleeding (HP:0000225)2.86368260
34Colitis (HP:0002583)2.84892577
35Abnormality of the common coagulation pathway (HP:0010990)2.82043142
36Epistaxis (HP:0000421)2.80269125
37Mediastinal lymphadenopathy (HP:0100721)2.79439783
38Granulocytopenia (HP:0001913)2.78044450
39Gangrene (HP:0100758)2.76199253
40Myocardial infarction (HP:0001658)2.73461442
41Anorexia (HP:0002039)2.69246206
42Increased IgM level (HP:0003496)2.66661212
43Increased cerebral lipofuscin (HP:0011813)2.66064357
44Abnormality of aromatic amino acid family metabolism (HP:0004338)2.65351462
45Xanthomatosis (HP:0000991)2.65205930
46Orchitis (HP:0100796)2.64434634
47Pustule (HP:0200039)2.63982826
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.61719610
49Chest pain (HP:0100749)2.61236574
50Dysostosis multiplex (HP:0000943)2.60603077
51Eosinophilia (HP:0001880)2.60292638
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.59353485
53Abnormality of the pleura (HP:0002103)2.58284817
54Inflammation of the large intestine (HP:0002037)2.53203483
55Polyneuropathy (HP:0001271)2.49643336
56Meningitis (HP:0001287)2.48840452
57Interstitial pulmonary disease (HP:0006530)2.48093315
58Abnormality of monocarboxylic acid metabolism (HP:0010996)2.47466025
59Impaired platelet aggregation (HP:0003540)2.46571735
60Abnormal platelet function (HP:0011869)2.46571735
61Prolonged bleeding time (HP:0003010)2.45411291
62Recurrent cutaneous fungal infections (HP:0011370)2.44212675
63Chronic mucocutaneous candidiasis (HP:0002728)2.44212675
64Periodontitis (HP:0000704)2.44011016
65Nephritis (HP:0000123)2.43966410
66Gastrointestinal inflammation (HP:0004386)2.43706511
67Abnormality of the nasal mucosa (HP:0000433)2.43529731
68Mucopolysacchariduria (HP:0008155)2.41262824
69Urinary glycosaminoglycan excretion (HP:0003541)2.41262824
70Autoimmune hemolytic anemia (HP:0001890)2.40965828
71Cellulitis (HP:0100658)2.38223085
72Petechiae (HP:0000967)2.34439822
73Abnormality of T cell physiology (HP:0011840)2.33147848
74Gastrointestinal stroma tumor (HP:0100723)2.32287635
75Hypergammaglobulinemia (HP:0010702)2.32009051
76IgM deficiency (HP:0002850)2.31032167
77Axonal loss (HP:0003447)2.29947334
78Urticaria (HP:0001025)2.29566764
79Vasculitis (HP:0002633)2.29346113
80Reduced antithrombin III activity (HP:0001976)2.29318559
81Amyloidosis (HP:0011034)2.28561145
82Hematochezia (HP:0002573)2.28241043
83Gingivitis (HP:0000230)2.28129920
84Panhypogammaglobulinemia (HP:0003139)2.27511756
85Lymphopenia (HP:0001888)2.27016217
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26309771
87Abnormality of polysaccharide metabolism (HP:0011012)2.26309771
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26309771
89Thrombophlebitis (HP:0004418)2.25907182
90Joint swelling (HP:0001386)2.25623532
91Abnormality of eosinophils (HP:0001879)2.22896447
92Hyperlipoproteinemia (HP:0010980)2.21897798
93Intrahepatic cholestasis (HP:0001406)2.21696713
94Glomerulopathy (HP:0100820)2.20648093
95Arterial thrombosis (HP:0004420)2.20520663
96Nasal polyposis (HP:0100582)2.19811465
97Obstructive lung disease (HP:0006536)2.19797529
98Chronic obstructive pulmonary disease (HP:0006510)2.19797529
99Abnormality of cells of the lymphoid lineage (HP:0012140)2.18861091
100Pulmonary embolism (HP:0002204)2.18546406
101Microcytic anemia (HP:0001935)2.17916254
102Episodic fever (HP:0001954)2.17703738
103Purpura (HP:0000979)2.17419741
104Loss of speech (HP:0002371)2.17358131
105Abnormality of the prostate (HP:0008775)2.14777744
106Esophageal varix (HP:0002040)2.14068892
107Recurrent sinusitis (HP:0011108)2.13392330
108Vertigo (HP:0002321)2.12884240
109Keratitis (HP:0000491)2.10587375
110IgG deficiency (HP:0004315)2.07850670
111Abnormality of B cell number (HP:0010975)2.05235835
112Menorrhagia (HP:0000132)2.05051580
113Stomatitis (HP:0010280)2.04945238
114Acne (HP:0001061)2.04451739
115Polycythemia (HP:0001901)2.04046276
116Restrictive lung disease (HP:0002091)2.03363218
117Premature loss of primary teeth (HP:0006323)2.03228280
118Abnormality of the endocardium (HP:0004306)2.03073246
119Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01964410
120Hypercholesterolemia (HP:0003124)2.01420234
121Basal ganglia calcification (HP:0002135)2.00859726
122Pulmonary infiltrates (HP:0002113)1.99767625
123Abnormality of iron homeostasis (HP:0011031)1.99726552
124Nonimmune hydrops fetalis (HP:0001790)1.99618080
125Osteomyelitis (HP:0002754)1.99140155
126Abnormality of the intrinsic pathway (HP:0010989)1.97912535
127Agammaglobulinemia (HP:0004432)1.97891245
128Increased serum ferritin (HP:0003281)1.97503667
129Gastrointestinal infarctions (HP:0005244)1.96773622
130Abnormality of T cells (HP:0002843)1.96072049
131Vertebral compression fractures (HP:0002953)1.95839228
132Thoracic kyphosis (HP:0002942)1.94953660
133Hemoptysis (HP:0002105)1.94038972
134Retrobulbar optic neuritis (HP:0100654)1.93865032
135Optic neuritis (HP:0100653)1.93865032
136Recurrent bronchitis (HP:0002837)1.93636862
137Peritonitis (HP:0002586)1.92071033

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.21950296
2KIT3.07462022
3MAP4K12.90273554
4TBK12.88998032
5TGFBR22.82828619
6TYK22.71910605
7IRAK42.47980887
8PRPF4B2.38741843
9BLK2.26298322
10MAP2K32.24964752
11IKBKE2.22550244
12TEC2.21014427
13MAP3K142.20479775
14FLT32.19909941
15IRAK32.19108162
16JAK32.12336203
17ZAP702.05747293
18KDR1.91079942
19NME21.83885905
20CSF1R1.83136696
21BTK1.80244386
22TAOK31.77164438
23IKBKB1.74683147
24FGFR41.67830387
25RIPK41.56722436
26EEF2K1.55317797
27TNK21.55286030
28JAK11.55033121
29FGR1.54940728
30TAOK11.53729123
31NLK1.53000811
32TXK1.52261191
33TIE11.44696110
34BMPR21.43208679
35RPS6KA41.42676072
36BCKDK1.41367488
37CSK1.35524405
38STK101.35078184
39PIM21.28321078
40EPHB11.27233686
41TRIB31.26699609
42ITK1.25623651
43SYK1.21763739
44TAOK21.20809316
45SIK31.20350349
46NEK91.15481618
47PKN21.15055200
48LYN1.10082339
49LCK1.09815370
50TGFBR11.07707249
51FES1.06597751
52LRRK21.02897052
53JAK21.00288381
54HCK0.97058361
55TRPM70.95908778
56MATK0.95456295
57MAP3K60.95322206
58MAP3K130.94513385
59SIK10.93799744
60TNIK0.92789534
61PIM10.90464045
62MAPKAPK30.89777404
63CDC42BPA0.87177804
64CHUK0.86770382
65EIF2AK30.86318783
66MAP3K100.84369859
67GRK60.83325830
68RIPK10.82340097
69SCYL20.81138565
70CAMK1D0.80141224
71MAP3K110.78435899
72PRKCQ0.77701237
73FGFR30.77027436
74IRAK10.76462347
75EPHA30.76459939
76MAPK110.75973625
77IRAK20.74875374
78MAPK70.74687051
79PDK10.74652031
80CLK10.74078905
81PTK60.73145737
82SIK20.73122667
83PIK3CG0.69238480
84PAK40.68414113
85YES10.65880090
86TESK20.63422184
87HIPK20.61351000
88MAPK40.59348254
89STK40.57126939
90PDPK10.56184287
91MARK20.55837866
92KSR20.55143645
93CDK60.54608054
94CAMKK10.54427936
95MAP3K50.53460392
96MAPKAPK50.51698534
97MAP3K30.50744512
98ABL20.48216542
99EIF2AK20.46006412
100FYN0.45914876
101MARK30.45889267
102MYLK0.45709987
103MAPK120.44810051
104PRKG20.42753235
105PRKD20.42398421
106ABL10.41982502
107RPS6KA60.40618840
108CDK40.40270623
109PRKCD0.39827599
110ACVR1B0.38922130
111RPS6KB20.37402093
112MAPKAPK20.37243074
113PRKAA20.36864411
114TTN0.36761938
115CAMKK20.36632175
116GRK70.36543845
117MAP3K120.35859293
118MAP3K20.35731277
119MAP3K70.35678012
120ADRBK20.35597897
121MOS0.34615725
122MAP3K10.34375319
123MST1R0.32740400
124NUAK10.31507144
125RPS6KL10.29652590
126RPS6KC10.29652590
127* EGFR0.26229160
128* IGF1R0.26113395
129MAP2K60.24781212
130SGK30.24663024
131CDK190.23098191

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.74055571
2Autoimmune thyroid disease_Homo sapiens_hsa053202.86964841
3Complement and coagulation cascades_Homo sapiens_hsa046102.56895625
4Leishmaniasis_Homo sapiens_hsa051402.53719912
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.48959290
6Type I diabetes mellitus_Homo sapiens_hsa049402.39661115
7Caffeine metabolism_Homo sapiens_hsa002322.22160617
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.10290878
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.00766957
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.93579404
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.87412299
12* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85233828
13Pertussis_Homo sapiens_hsa051331.84319396
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.73915545
15* Osteoclast differentiation_Homo sapiens_hsa043801.72804674
16Malaria_Homo sapiens_hsa051441.71649856
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69474084
18Viral myocarditis_Homo sapiens_hsa054161.68656523
19T cell receptor signaling pathway_Homo sapiens_hsa046601.65664869
20Legionellosis_Homo sapiens_hsa051341.65131421
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62678302
22Other glycan degradation_Homo sapiens_hsa005111.60914009
23* Measles_Homo sapiens_hsa051621.55524641
24Primary immunodeficiency_Homo sapiens_hsa053401.53155518
25Antigen processing and presentation_Homo sapiens_hsa046121.51717568
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.50370244
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.37144174
28Fatty acid degradation_Homo sapiens_hsa000711.35408262
29Tuberculosis_Homo sapiens_hsa051521.30911855
30Hematopoietic cell lineage_Homo sapiens_hsa046401.28643414
31B cell receptor signaling pathway_Homo sapiens_hsa046621.28593738
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28347017
33Lysosome_Homo sapiens_hsa041421.27409400
34ABC transporters_Homo sapiens_hsa020101.27012880
35Tryptophan metabolism_Homo sapiens_hsa003801.26607005
36Arginine biosynthesis_Homo sapiens_hsa002201.26116115
37Peroxisome_Homo sapiens_hsa041461.23267447
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.21159041
39Chemical carcinogenesis_Homo sapiens_hsa052041.20938037
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19577661
41PPAR signaling pathway_Homo sapiens_hsa033201.18006112
42* Herpes simplex infection_Homo sapiens_hsa051681.16040291
43* Influenza A_Homo sapiens_hsa051641.13793989
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13347051
45Toxoplasmosis_Homo sapiens_hsa051451.12851371
46Selenocompound metabolism_Homo sapiens_hsa004501.10121996
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09579881
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08023184
49Nitrogen metabolism_Homo sapiens_hsa009101.06968198
50TNF signaling pathway_Homo sapiens_hsa046681.04640288
51Histidine metabolism_Homo sapiens_hsa003401.03401026
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01327899
53Sulfur relay system_Homo sapiens_hsa041221.00875378
54* Jak-STAT signaling pathway_Homo sapiens_hsa046300.98056456
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97873426
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94292204
57Allograft rejection_Homo sapiens_hsa053300.93956319
58Starch and sucrose metabolism_Homo sapiens_hsa005000.93839740
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.90911686
60* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90051661
61Acute myeloid leukemia_Homo sapiens_hsa052210.88324698
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86606774
63* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86205200
64Folate biosynthesis_Homo sapiens_hsa007900.85962963
65Apoptosis_Homo sapiens_hsa042100.85811841
66beta-Alanine metabolism_Homo sapiens_hsa004100.85067114
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83717999
68Pentose phosphate pathway_Homo sapiens_hsa000300.82931356
69African trypanosomiasis_Homo sapiens_hsa051430.82650461
70Graft-versus-host disease_Homo sapiens_hsa053320.79956350
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79755017
72Hepatitis B_Homo sapiens_hsa051610.79702790
73Fatty acid metabolism_Homo sapiens_hsa012120.78718421
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78231274
75Shigellosis_Homo sapiens_hsa051310.77217009
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76751276
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.76272894
78Epstein-Barr virus infection_Homo sapiens_hsa051690.76177418
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75925656
80Retinol metabolism_Homo sapiens_hsa008300.75117890
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75038728
82Salmonella infection_Homo sapiens_hsa051320.74838279
83Asthma_Homo sapiens_hsa053100.72909975
84Prolactin signaling pathway_Homo sapiens_hsa049170.69693643
85Non-small cell lung cancer_Homo sapiens_hsa052230.66269149
86DNA replication_Homo sapiens_hsa030300.66146049
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65198495
88* Hepatitis C_Homo sapiens_hsa051600.63648256
89Phagosome_Homo sapiens_hsa041450.61108798
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60654962
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59782681
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.59036402
93Platelet activation_Homo sapiens_hsa046110.57848241
94VEGF signaling pathway_Homo sapiens_hsa043700.57738968
95Chemokine signaling pathway_Homo sapiens_hsa040620.57072226
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55459217
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.55331079
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.55019929
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54059526
100HTLV-I infection_Homo sapiens_hsa051660.53812030
101Fatty acid elongation_Homo sapiens_hsa000620.52436759
102Vitamin digestion and absorption_Homo sapiens_hsa049770.51954814
103Propanoate metabolism_Homo sapiens_hsa006400.51582861
104Glutathione metabolism_Homo sapiens_hsa004800.51308632
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50416246
106Viral carcinogenesis_Homo sapiens_hsa052030.48046720
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47932901
108N-Glycan biosynthesis_Homo sapiens_hsa005100.47597894
109One carbon pool by folate_Homo sapiens_hsa006700.47146940
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46115793
111Rheumatoid arthritis_Homo sapiens_hsa053230.46082449
112Amoebiasis_Homo sapiens_hsa051460.45740744
113Lysine degradation_Homo sapiens_hsa003100.45082842
114Chronic myeloid leukemia_Homo sapiens_hsa052200.44816734
115Pancreatic cancer_Homo sapiens_hsa052120.43454266
116Insulin resistance_Homo sapiens_hsa049310.43072878
117Renal cell carcinoma_Homo sapiens_hsa052110.39046365
118Endocytosis_Homo sapiens_hsa041440.38792533
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38398157
120FoxO signaling pathway_Homo sapiens_hsa040680.37850694
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36898626
122HIF-1 signaling pathway_Homo sapiens_hsa040660.36664756
123Dorso-ventral axis formation_Homo sapiens_hsa043200.35604392
124Systemic lupus erythematosus_Homo sapiens_hsa053220.28292914
125Type II diabetes mellitus_Homo sapiens_hsa049300.28258629
126Notch signaling pathway_Homo sapiens_hsa043300.27310689
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.25847362
128GnRH signaling pathway_Homo sapiens_hsa049120.24874656
129MAPK signaling pathway_Homo sapiens_hsa040100.24485181
130Prion diseases_Homo sapiens_hsa050200.23686935
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23405672
132Bladder cancer_Homo sapiens_hsa052190.20792490
133Collecting duct acid secretion_Homo sapiens_hsa049660.19034079
134Sphingolipid metabolism_Homo sapiens_hsa006000.17839014
135mTOR signaling pathway_Homo sapiens_hsa041500.17049168
136Arachidonic acid metabolism_Homo sapiens_hsa005900.15599529
137Choline metabolism in cancer_Homo sapiens_hsa052310.15383225
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.13840292
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13818932

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