IFNB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)8.69147390
2regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)7.80295762
3* cellular response to type I interferon (GO:0071357)7.78310340
4* type I interferon signaling pathway (GO:0060337)7.78310340
5* response to type I interferon (GO:0034340)7.66112460
6regulation of activation of Janus kinase activity (GO:0010533)7.18266328
7cellular response to interferon-alpha (GO:0035457)7.01085382
8positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.61578124
9regulation of T-helper 1 cell differentiation (GO:0045625)6.24664203
10positive regulation of heat generation (GO:0031652)6.13591002
11regulation of fever generation (GO:0031620)6.10312718
12response to peptidoglycan (GO:0032494)6.05215965
13positive regulation of T-helper cell differentiation (GO:0045624)5.72756913
14positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.67035587
15response to interferon-alpha (GO:0035455)5.42475658
16positive regulation of T-helper 1 type immune response (GO:0002827)5.30352393
17* positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.26225933
18* regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.26225933
19regulation of memory T cell differentiation (GO:0043380)5.18812004
20lipopolysaccharide-mediated signaling pathway (GO:0031663)5.18732254
21positive regulation of chemokine biosynthetic process (GO:0045080)4.97174256
22positive regulation of NF-kappaB import into nucleus (GO:0042346)4.90260529
23* regulation of MHC class I biosynthetic process (GO:0045343)4.88861090
24* regulation of type I interferon-mediated signaling pathway (GO:0060338)4.86649101
25positive regulation of alpha-beta T cell proliferation (GO:0046641)4.82212099
26positive regulation of interferon-alpha production (GO:0032727)4.76130096
27regulation of heat generation (GO:0031650)4.67843458
28regulation of cytokine secretion involved in immune response (GO:0002739)4.62519176
29regulation of T-helper cell differentiation (GO:0045622)4.56198826
30positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.55439373
31negative regulation by host of viral transcription (GO:0043922)4.54786412
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.50053320
33regulation of lymphocyte chemotaxis (GO:1901623)4.47122925
34regulation of interferon-alpha production (GO:0032647)4.46921338
35regulation of chemokine biosynthetic process (GO:0045073)4.46815225
36positive regulation of interleukin-12 production (GO:0032735)4.41755380
37regulation of T-helper 1 type immune response (GO:0002825)4.41718093
38regulation of interleukin-2 biosynthetic process (GO:0045076)4.41540091
39* natural killer cell activation involved in immune response (GO:0002323)4.37187093
40interferon-gamma-mediated signaling pathway (GO:0060333)4.32869582
41negative regulation of interleukin-12 production (GO:0032695)4.31668501
42regulation of heterotypic cell-cell adhesion (GO:0034114)4.29761674
43regulation of vitamin D biosynthetic process (GO:0060556)4.27284055
44positive regulation of nitric oxide biosynthetic process (GO:0045429)4.23881090
45response to muramyl dipeptide (GO:0032495)4.15623271
46* defense response to virus (GO:0051607)4.10069772
47eosinophil chemotaxis (GO:0048245)4.09287677
48positive regulation of interleukin-17 production (GO:0032740)4.08324781
49negative regulation of amino acid transport (GO:0051956)3.99562048
50positive regulation of lymphocyte migration (GO:2000403)3.99021397
51* regulation of viral genome replication (GO:0045069)3.95734127
52positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.94353858
53regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.91353516
54positive regulation of interleukin-2 production (GO:0032743)3.87118352
55regulation of alpha-beta T cell proliferation (GO:0046640)3.86517070
56regulation of RIG-I signaling pathway (GO:0039535)3.86142875
57immunoglobulin mediated immune response (GO:0016064)3.85734335
58regulation of interleukin-17 production (GO:0032660)3.84717846
59positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.83556911
60regulation of interferon-beta biosynthetic process (GO:0045357)3.81573234
61* response to exogenous dsRNA (GO:0043330)3.80573930
62* negative regulation of viral process (GO:0048525)3.79490466
63regulation of dendritic cell antigen processing and presentation (GO:0002604)3.78212525
64regulation of vitamin metabolic process (GO:0030656)3.77425070
65positive regulation of defense response to virus by host (GO:0002230)3.72847376
66regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.71044014
67positive regulation of interleukin-10 production (GO:0032733)3.70536296
68cellular response to nicotine (GO:0071316)3.65362794
69T cell migration (GO:0072678)3.64481992
70lymphocyte chemotaxis (GO:0048247)3.61363846
71positive regulation by organism of defense response of other organism involved in symbiotic interact3.61098315
72modulation by symbiont of host immune response (GO:0052553)3.61098315
73positive regulation by symbiont of host defense response (GO:0052509)3.61098315
74modulation by symbiont of host defense response (GO:0052031)3.61098315
75modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.61098315
76modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.61098315
77positive regulation of cAMP-mediated signaling (GO:0043950)3.60751814
78positive regulation of mast cell activation involved in immune response (GO:0033008)3.57234173
79positive regulation of mast cell degranulation (GO:0043306)3.57234173
80neutrophil activation involved in immune response (GO:0002283)3.57228765
81eosinophil migration (GO:0072677)3.56888336
82monocyte chemotaxis (GO:0002548)3.55785587
83branching involved in labyrinthine layer morphogenesis (GO:0060670)3.55738354
84myeloid dendritic cell differentiation (GO:0043011)3.55550172
85macrophage activation involved in immune response (GO:0002281)3.55331424
86positive regulation of monocyte chemotaxis (GO:0090026)3.54948068
87regulation of immunoglobulin secretion (GO:0051023)3.54747527
88positive regulation of activated T cell proliferation (GO:0042104)3.54078752
89NIK/NF-kappaB signaling (GO:0038061)3.53484590
90response to protozoan (GO:0001562)3.49448713
91positive regulation of T cell mediated cytotoxicity (GO:0001916)3.48831898
92negative regulation of myeloid cell apoptotic process (GO:0033033)3.46880411
93cellular response to interferon-gamma (GO:0071346)3.46457728
94negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.45598891
95* cellular response to exogenous dsRNA (GO:0071360)3.43472848
96positive regulation of T cell mediated immunity (GO:0002711)3.42503524
97regulation of interleukin-8 biosynthetic process (GO:0045414)3.41778480
98leukocyte aggregation (GO:0070486)3.39536277
99superoxide anion generation (GO:0042554)3.39182921
100activation of MAPKKK activity (GO:0000185)3.39175121
101negative regulation of interleukin-17 production (GO:0032700)3.37183313
102regulation of nitric oxide biosynthetic process (GO:0045428)3.36148073
103production of molecular mediator involved in inflammatory response (GO:0002532)3.35476481
104positive regulation of leukocyte chemotaxis (GO:0002690)3.34921363
105regulation of chronic inflammatory response (GO:0002676)3.33656783
106cellular response to virus (GO:0098586)3.31835360
107positive regulation of type 2 immune response (GO:0002830)3.31103205
108granulocyte activation (GO:0036230)3.30886993
109hydrogen peroxide biosynthetic process (GO:0050665)3.30648217
110cellular response to lipopolysaccharide (GO:0071222)3.30530531
111regulation of mononuclear cell migration (GO:0071675)3.30487925
112regulation of vascular endothelial growth factor production (GO:0010574)3.29611574
113positive regulation of tumor necrosis factor production (GO:0032760)3.28868997
114regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.28716682
115regulation of NF-kappaB import into nucleus (GO:0042345)3.28239370
116negative regulation of type I interferon production (GO:0032480)3.27969398
117negative regulation of growth of symbiont in host (GO:0044130)3.26989020
118negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.26989020
119modulation of growth of symbiont involved in interaction with host (GO:0044144)3.26989020
120regulation of growth of symbiont in host (GO:0044126)3.26989020
121positive regulation of humoral immune response (GO:0002922)3.26701141
122positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.26180272
123regulation of interleukin-12 production (GO:0032655)3.25886796
124* negative regulation of viral genome replication (GO:0045071)3.25513881
125regulation of podosome assembly (GO:0071801)3.24857747
126defense response to protozoan (GO:0042832)3.24464986
127regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.24373662
128negative regulation of nitric oxide biosynthetic process (GO:0045019)3.22527115
129positive regulation of cellular amide metabolic process (GO:0034250)3.22165332
130regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.21633757
131response to interferon-gamma (GO:0034341)3.19400442
132regulation of inflammatory response to antigenic stimulus (GO:0002861)3.18340626
133positive regulation of transcription factor import into nucleus (GO:0042993)3.17952048
134positive regulation of macrophage cytokine production (GO:0060907)3.17754733
135cellular response to molecule of bacterial origin (GO:0071219)3.17619111
136* response to interferon-beta (GO:0035456)3.17352246
137* regulation of type 2 immune response (GO:0002828)3.17053289
138regulation of interferon-beta production (GO:0032648)3.16111229
139positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.15408859
140positive regulation vascular endothelial growth factor production (GO:0010575)3.15235057
141* response to dsRNA (GO:0043331)3.13829166
142positive regulation of acute inflammatory response (GO:0002675)3.13443879
143regulation of membrane protein ectodomain proteolysis (GO:0051043)3.12210984
144regulation of lymphocyte migration (GO:2000401)3.10716495
145positive regulation of interferon-beta production (GO:0032728)3.10637482
146positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.10383580
147regulation of defense response to virus by host (GO:0050691)3.10256157
148positive regulation of neutrophil chemotaxis (GO:0090023)3.09501259
149positive regulation of neutrophil migration (GO:1902624)3.09501259
150positive regulation of antigen processing and presentation (GO:0002579)3.09354826
151lymphocyte migration (GO:0072676)3.07490165
152regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.06723566
153positive regulation of cytokine biosynthetic process (GO:0042108)3.05285623
154positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.05226397
155positive regulation of interleukin-6 production (GO:0032755)3.04673780
156dendritic cell differentiation (GO:0097028)3.04375313
157* negative regulation of cytokine production involved in immune response (GO:0002719)3.03844668
158positive regulation of toll-like receptor signaling pathway (GO:0034123)3.01701628
159positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.98120031
160B cell mediated immunity (GO:0019724)2.96562993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.32586950
2* IRF8_21731497_ChIP-ChIP_J774_Mouse5.91151443
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.61178466
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.57337998
5* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.52486384
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.45044622
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.19432551
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.09697113
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95486851
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.43437773
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42036833
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28423929
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.15988956
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08852221
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08137605
16BP1_19119308_ChIP-ChIP_Hs578T_Human11.6277217
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.99298252
18STAT4_19710469_ChIP-ChIP_TH1__Mouse1.95703817
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88071661
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80065197
21VDR_24787735_ChIP-Seq_THP-1_Human1.75147402
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64880873
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62746436
24* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62093265
25* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58194763
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56579326
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54344120
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.52602658
29MAF_26560356_Chip-Seq_TH1_Human1.43013651
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42017967
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41639917
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34016294
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33549352
34PU_27001747_Chip-Seq_BMDM_Mouse1.30733034
35* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30586314
36CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26584070
37VDR_21846776_ChIP-Seq_THP-1_Human1.24886181
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22503262
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21822227
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.20248378
41SCL_19346495_ChIP-Seq_HPC-7_Human1.18886299
42RUNX_20019798_ChIP-Seq_JUKART_Human1.17813342
43MYB_26560356_Chip-Seq_TH1_Human1.14046167
44VDR_24763502_ChIP-Seq_THP-1_Human1.13816695
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13406896
46GATA1_22025678_ChIP-Seq_K562_Human1.12825003
47SPI1_23547873_ChIP-Seq_NB4_Human1.12763869
48SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10979965
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08419548
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08419548
51TP53_18474530_ChIP-ChIP_U2OS_Human1.07424632
52CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07408558
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07374055
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07374055
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07374055
56SOX2_20726797_ChIP-Seq_SW620_Human1.07067207
57GATA2_21666600_ChIP-Seq_HMVEC_Human1.06657589
58* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06456024
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03816241
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02743250
61VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00765629
62* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00571096
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99522333
64FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98891957
65* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96773524
66EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93722420
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93545098
68ELK3_25401928_ChIP-Seq_HUVEC_Human0.92435633
69IGF1R_20145208_ChIP-Seq_DFB_Human0.91993452
70STAT1_20625510_ChIP-Seq_HELA_Human0.90330093
71TCF7_22412390_ChIP-Seq_EML_Mouse0.88979884
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88464284
73* CJUN_26792858_Chip-Seq_BT549_Human0.87512845
74MAF_26560356_Chip-Seq_TH2_Human0.87492617
75GATA3_26560356_Chip-Seq_TH2_Human0.86496633
76SPI1_23127762_ChIP-Seq_K562_Human0.86443088
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.86378652
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86207833
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86170978
80TP63_17297297_ChIP-ChIP_HaCaT_Human0.84607640
81STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84453853
82KDM2B_26808549_Chip-Seq_DND41_Human0.84195569
83* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82890589
84* MYB_26560356_Chip-Seq_TH2_Human0.82099948
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81916472
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81001519
87* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80988808
88ESR1_21235772_ChIP-Seq_MCF-7_Human0.80803736
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80262972
90GATA1_19941826_ChIP-Seq_K562_Human0.80123994
91TP53_16413492_ChIP-PET_HCT116_Human0.79548831
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78390769
93* UTX_26944678_Chip-Seq_JUKART_Human0.77534638
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.76358072
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75955021
96CDX2_20551321_ChIP-Seq_CACO-2_Human0.75419366
97RUNX1_22412390_ChIP-Seq_EML_Mouse0.75409548
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74306773
99GATA3_27048872_Chip-Seq_THYMUS_Human0.74142003
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74137055
101TFEB_21752829_ChIP-Seq_HELA_Human0.73371079
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72906452
103SALL4_22934838_ChIP-ChIP_CD34+_Human0.71684013
104LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.71424728
105SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.71402930
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.71402930
107LXR_22158963_ChIP-Seq_LIVER_Mouse0.70606974
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69131704
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.68232136
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.67656070
111PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67297539
112* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66149509
113SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66078893
114RARG_19884340_ChIP-ChIP_MEFs_Mouse0.65444390
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.64685379
116PU1_27457419_Chip-Seq_LIVER_Mouse0.63955871
117STAT3_18555785_Chip-Seq_ESCs_Mouse0.63696489
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.63568830
119LXR_22292898_ChIP-Seq_THP-1_Human0.62713814
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.62616332
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.62580910
122SMAD1_18555785_Chip-Seq_ESCs_Mouse0.62219773
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.61998852
124* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61621334
125ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.61534549
126SUZ12_18555785_Chip-Seq_ESCs_Mouse0.59957607
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.59886684
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.58949630
129GATA2_19941826_ChIP-Seq_K562_Human0.58436183
130P63_26484246_Chip-Seq_KERATINOCYTES_Human0.58399351
131EGR1_19032775_ChIP-ChIP_M12_Human0.58341561
132OCT4_21477851_ChIP-Seq_ESCs_Mouse0.57939967
133RXR_22158963_ChIP-Seq_LIVER_Mouse0.57602141
134P53_22387025_ChIP-Seq_ESCs_Mouse0.57363970
135NMYC_18555785_Chip-Seq_ESCs_Mouse0.56999056
136RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.56647374

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.98246802
2* MP0006082_CNS_inflammation4.55442978
3MP0002148_abnormal_hypersensitivity_rea4.40008651
4MP0003724_increased_susceptibility_to4.39336067
5MP0003436_decreased_susceptibility_to4.13549501
6MP0003303_peritoneal_inflammation3.96279274
7MP0001835_abnormal_antigen_presentation3.57069626
8* MP0005000_abnormal_immune_tolerance3.55845333
9* MP0002419_abnormal_innate_immunity3.10222833
10MP0002006_tumorigenesis3.02835848
11* MP0005025_abnormal_response_to3.01963693
12MP0009764_decreased_sensitivity_to2.84489562
13MP0003300_gastrointestinal_ulcer2.43406595
14MP0008004_abnormal_stomach_pH2.42710685
15MP0005623_abnormal_meninges_morphology2.37051371
16* MP0002723_abnormal_immune_serum2.32911635
17* MP0002452_abnormal_antigen_presenting2.30640063
18MP0004510_myositis2.27097703
19MP0001800_abnormal_humoral_immune2.21866284
20MP0004947_skin_inflammation2.21520107
21MP0009278_abnormal_bone_marrow2.19504214
22MP0005167_abnormal_blood-brain_barrier2.16833959
23MP0001533_abnormal_skeleton_physiology2.10838922
24MP0005671_abnormal_response_to2.09450524
25MP0001853_heart_inflammation2.07504895
26MP0005451_abnormal_body_composition2.01457936
27MP0005387_immune_system_phenotype1.97328616
28MP0001790_abnormal_immune_system1.97328616
29MP0002139_abnormal_hepatobiliary_system1.96530476
30MP0005464_abnormal_platelet_physiology1.95951932
31MP0003075_altered_response_to1.95604925
32* MP0008469_abnormal_protein_level1.89082864
33* MP0001819_abnormal_immune_cell1.86323791
34MP0001845_abnormal_inflammatory_respons1.85594662
35* MP0002420_abnormal_adaptive_immunity1.81338632
36MP0005166_decreased_susceptibility_to1.72852833
37MP0010155_abnormal_intestine_physiology1.70861751
38MP0005164_abnormal_response_to1.70160654
39MP0006054_spinal_hemorrhage1.67374442
40MP0003828_pulmonary_edema1.64957037
41MP0000858_altered_metastatic_potential1.61335064
42MP0005058_abnormal_lysosome_morphology1.56362491
43MP0002138_abnormal_hepatobiliary_system1.55767920
44MP0002254_reproductive_system_inflammat1.52282800
45MP0009333_abnormal_splenocyte_physiolog1.50734671
46MP0000685_abnormal_immune_system1.48485998
47MP0002277_abnormal_respiratory_mucosa1.46683964
48MP0000343_altered_response_to1.38904233
49MP0002405_respiratory_system_inflammati1.38773668
50MP0005397_hematopoietic_system_phenotyp1.37120230
51MP0001545_abnormal_hematopoietic_system1.37120230
52* MP0003690_abnormal_glial_cell1.33308152
53MP0003806_abnormal_nucleotide_metabolis1.29507936
54MP0003191_abnormal_cellular_cholesterol1.29379577
55MP0009765_abnormal_xenobiotic_induced1.24965676
56MP0003453_abnormal_keratinocyte_physiol1.24611819
57MP0002332_abnormal_exercise_endurance1.21349033
58MP0003656_abnormal_erythrocyte_physiolo1.15706249
59MP0004883_abnormal_blood_vessel1.14627310
60* MP0000716_abnormal_immune_system1.12087865
61MP0005535_abnormal_body_temperature1.12020323
62MP0009763_increased_sensitivity_to1.11890980
63* MP0003448_altered_tumor_morphology1.10979146
64MP0010352_gastrointestinal_tract_polyps1.09630628
65MP0000604_amyloidosis1.05378843
66MP0009840_abnormal_foam_cell1.04515446
67MP0002998_abnormal_bone_remodeling1.03741140
68MP0002163_abnormal_gland_morphology1.01997098
69MP0001348_abnormal_lacrimal_gland1.01260428
70MP0002933_joint_inflammation1.00423074
71MP0005310_abnormal_salivary_gland0.98886715
72* MP0002398_abnormal_bone_marrow0.96976745
73MP0001542_abnormal_bone_strength0.95698327
74MP0005390_skeleton_phenotype0.93189716
75MP0002736_abnormal_nociception_after0.92856265
76MP0003195_calcinosis0.91204795
77MP0001968_abnormal_touch/_nociception0.88022855
78MP0003763_abnormal_thymus_physiology0.85297203
79* MP0002429_abnormal_blood_cell0.84551147
80MP0000249_abnormal_blood_vessel0.84236583
81MP0003045_fibrosis0.82599738
82MP0003950_abnormal_plasma_membrane0.81280913
83MP0003221_abnormal_cardiomyocyte_apopto0.78222070
84MP0001501_abnormal_sleep_pattern0.77649656
85MP0001873_stomach_inflammation0.75574603
86* MP0000920_abnormal_myelination0.75477091
87MP0005647_abnormal_sex_gland0.72414007
88MP0002722_abnormal_immune_system0.70165344
89MP0004808_abnormal_hematopoietic_stem0.70141067
90MP0003172_abnormal_lysosome_physiology0.70041174
91* MP0000689_abnormal_spleen_morphology0.68389718
92MP0008260_abnormal_autophagy0.67255111
93MP0003186_abnormal_redox_activity0.66367676
94MP0005023_abnormal_wound_healing0.65630845
95MP0005666_abnormal_adipose_tissue0.64374121
96MP0005266_abnormal_metabolism0.63659318
97MP0002136_abnormal_kidney_physiology0.63571009
98MP0002693_abnormal_pancreas_physiology0.62909531
99MP0005379_endocrine/exocrine_gland_phen0.62342678
100MP0001851_eye_inflammation0.62158940
101MP0008874_decreased_physiological_sensi0.59576829
102MP0004484_altered_response_of0.58779683
103MP0003183_abnormal_peptide_metabolism0.57249787
104MP0002877_abnormal_melanocyte_morpholog0.56619652
105MP0003252_abnormal_bile_duct0.55947275
106MP0010307_abnormal_tumor_latency0.55377534
107MP0010386_abnormal_urinary_bladder0.55027921
108MP0002168_other_aberrant_phenotype0.54862971
109MP0004782_abnormal_surfactant_physiolog0.54748917
110MP0001663_abnormal_digestive_system0.53435613
111MP0004130_abnormal_muscle_cell0.51517777
112MP0001346_abnormal_lacrimal_gland0.51411356
113* MP0003795_abnormal_bone_structure0.49560633
114MP0005076_abnormal_cell_differentiation0.48471992
115MP0009115_abnormal_fat_cell0.47776398
116MP0002295_abnormal_pulmonary_circulatio0.46727688
117MP0001958_emphysema0.43806801
118MP0003091_abnormal_cell_migration0.43572217
119MP0003646_muscle_fatigue0.42800997
120MP0005165_increased_susceptibility_to0.42363257
121MP0008873_increased_physiological_sensi0.42197918
122MP0000609_abnormal_liver_physiology0.41027531

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.80237889
2Recurrent gram-negative bacterial infections (HP:0005420)6.33372182
3Recurrent bacterial skin infections (HP:0005406)6.27120484
4Eczematoid dermatitis (HP:0000976)6.08653180
5Systemic lupus erythematosus (HP:0002725)6.06159044
6Mediastinal lymphadenopathy (HP:0100721)5.69318220
7Elevated erythrocyte sedimentation rate (HP:0003565)5.67114964
8Stomatitis (HP:0010280)5.65937681
9Retrobulbar optic neuritis (HP:0100654)5.34552424
10Optic neuritis (HP:0100653)5.34552424
11Orchitis (HP:0100796)5.17118795
12Loss of speech (HP:0002371)4.92089432
13Abnormality of macrophages (HP:0004311)4.74501815
14Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.66957309
15Myositis (HP:0100614)4.63778620
16Basal ganglia calcification (HP:0002135)4.46861948
17Interstitial pulmonary disease (HP:0006530)4.28886562
18Recurrent skin infections (HP:0001581)3.86074664
19Dysostosis multiplex (HP:0000943)3.84109145
20Prolonged neonatal jaundice (HP:0006579)3.78577999
21Hemorrhage of the eye (HP:0011885)3.76648136
22Vasculitis (HP:0002633)3.70909512
23Pulmonary infiltrates (HP:0002113)3.70224735
24Vacuolated lymphocytes (HP:0001922)3.67966080
25Nuclear cataract (HP:0100018)3.64785532
26Axonal loss (HP:0003447)3.55928590
27Mutism (HP:0002300)3.42085508
28Gingivitis (HP:0000230)3.38489577
29Petechiae (HP:0000967)3.35578287
30Prostate neoplasm (HP:0100787)3.24231495
31Increased neuronal autofluorescent lipopigment (HP:0002074)3.22943052
32Purpura (HP:0000979)3.21095194
33Fused cervical vertebrae (HP:0002949)3.16801723
34Porencephaly (HP:0002132)3.15308472
35Keratoconjunctivitis sicca (HP:0001097)3.12594906
36Nausea (HP:0002018)3.12184445
37Poor head control (HP:0002421)3.11013386
38Increased cerebral lipofuscin (HP:0011813)3.06994092
39Hepatosplenomegaly (HP:0001433)3.03140741
40Chronic obstructive pulmonary disease (HP:0006510)3.02957985
41Obstructive lung disease (HP:0006536)3.02957985
42Recurrent fungal infections (HP:0002841)3.01117269
43Apathy (HP:0000741)2.99805992
44Autoimmune hemolytic anemia (HP:0001890)2.99535486
45Abnormality of the pericardium (HP:0001697)2.97636819
46Spastic tetraparesis (HP:0001285)2.90249148
47Agnosia (HP:0010524)2.89070627
48Disinhibition (HP:0000734)2.87069062
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.86428285
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.86428285
51Abnormality of polysaccharide metabolism (HP:0011012)2.86428285
52Diminished motivation (HP:0000745)2.82621791
53Nephritis (HP:0000123)2.81807812
54Keratoconjunctivitis (HP:0001096)2.81673915
55Hematochezia (HP:0002573)2.80790396
56Pigmentary retinal degeneration (HP:0001146)2.80523129
57Progressive neurologic deterioration (HP:0002344)2.78553257
58Arterial thrombosis (HP:0004420)2.77775681
59Parakeratosis (HP:0001036)2.70153731
60Pustule (HP:0200039)2.69617431
61Urinary glycosaminoglycan excretion (HP:0003541)2.68234031
62Mucopolysacchariduria (HP:0008155)2.68234031
63Increased serum ferritin (HP:0003281)2.66313739
64Myocardial infarction (HP:0001658)2.65593826
65Joint swelling (HP:0001386)2.62633194
66Chronic mucocutaneous candidiasis (HP:0002728)2.61330288
67Recurrent cutaneous fungal infections (HP:0011370)2.61330288
68Recurrent viral infections (HP:0004429)2.60931992
69Periodontitis (HP:0000704)2.60278481
70Bilateral sensorineural hearing impairment (HP:0008619)2.56964542
71Polyneuropathy (HP:0001271)2.56468626
72Cellulitis (HP:0100658)2.49317272
73Autoimmune thrombocytopenia (HP:0001973)2.49204875
74Choroideremia (HP:0001139)2.48730590
75Abnormality of the pleura (HP:0002103)2.48158372
76Joint hemorrhage (HP:0005261)2.47735726
77Lower limb hyperreflexia (HP:0002395)2.47623923
78Hemoptysis (HP:0002105)2.43496163
79Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.40736450
80Inappropriate behavior (HP:0000719)2.39923409
81Encephalitis (HP:0002383)2.37890255
82T lymphocytopenia (HP:0005403)2.37510665
83Xerostomia (HP:0000217)2.37258648
84Cleft eyelid (HP:0000625)2.36330631
85Abnormality of T cell number (HP:0011839)2.33506139
86Acrocyanosis (HP:0001063)2.33303258
87Abnormality of the prostate (HP:0008775)2.31356242
88Glomerulonephritis (HP:0000099)2.30850833
89Meningitis (HP:0001287)2.27536620
90Anorexia (HP:0002039)2.25742772
91Vertigo (HP:0002321)2.25020594
92Abnormality of the endocardium (HP:0004306)2.24886899
93Abnormality of B cell number (HP:0010975)2.23436026
94Bone pain (HP:0002653)2.21516280
95Gingival bleeding (HP:0000225)2.20697988
96Memory impairment (HP:0002354)2.19774339
97Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.19047172
98Abnormality of the vasculature of the conjunctiva (HP:0008054)2.17951170
99Amyloidosis (HP:0011034)2.16802630
100Thick nail (HP:0001805)2.15224763
101Arthralgia (HP:0002829)2.14026058
102Stenosis of the external auditory canal (HP:0000402)2.12039285
103Cerebral inclusion bodies (HP:0100314)2.11778744
104Nasal polyposis (HP:0100582)2.10209257
105Increased IgM level (HP:0003496)2.10150100
106Leukocytosis (HP:0001974)2.09333912
107Metaphyseal irregularity (HP:0003025)2.07966485
108B lymphocytopenia (HP:0010976)2.07882022
109Progressive visual loss (HP:0000529)2.07189970
110Pulmonary artery stenosis (HP:0004415)2.06381427
111Pathologic fracture (HP:0002756)2.05432616
112Abnormality of the nasal mucosa (HP:0000433)2.04944161
113Recurrent pneumonia (HP:0006532)2.04681104
114Glomerulopathy (HP:0100820)2.03713891
115Abnormality of iron homeostasis (HP:0011031)2.02495127
116Personality changes (HP:0000751)2.00789381
117Thoracolumbar scoliosis (HP:0002944)2.00006874
118Abnormality of the basal ganglia (HP:0002134)1.99259848
119Acne (HP:0001061)1.99077251
120Urticaria (HP:0001025)1.97524783
121Neuronal loss in central nervous system (HP:0002529)1.97431123
122Hypergammaglobulinemia (HP:0010702)1.96423244
123Neurofibrillary tangles (HP:0002185)1.93473290
124Pulmonary embolism (HP:0002204)1.91933865
125Osteomyelitis (HP:0002754)1.89690522
126Gangrene (HP:0100758)1.89685820
127Plagiocephaly (HP:0001357)1.88770532
128Upper motor neuron abnormality (HP:0002127)1.88400357
129Cheilitis (HP:0100825)1.86800862
130Abnormality of complement system (HP:0005339)1.85300692
131Micronodular cirrhosis (HP:0001413)1.83289678
132Abnormality of the nasal septum (HP:0000419)1.81310782
133Hemiparesis (HP:0001269)1.80782809
134Chronic otitis media (HP:0000389)1.76795295
135Abnormality of liposaccharide metabolism (HP:0010968)1.75287491
136Abnormality of glycosphingolipid metabolism (HP:0004343)1.75287491
137Abnormality of glycolipid metabolism (HP:0010969)1.75287491
138Premature loss of primary teeth (HP:0006323)1.75271399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.96899419
2IRAK34.57524417
3BLK4.16594198
4TBK14.07444908
5RIPK43.87443908
6PBK3.71792702
7TXK3.49529662
8RIPK13.47305246
9ADRBK22.84829677
10FGFR42.83080856
11FGR2.80976020
12PIM22.51467547
13MAP3K132.49736752
14IKBKB2.49365889
15IRAK42.45591038
16DDR22.36790336
17PRPF4B2.34714951
18IKBKE2.16145979
19MAP4K12.15352789
20JAK31.91709382
21BMX1.83355321
22CSK1.81410554
23TAOK11.78118151
24GRK71.64526998
25MAP3K111.63697727
26CHUK1.57068698
27FGFR31.51018245
28MAP3K31.48493692
29BMPR21.48393456
30TYK21.44258652
31JAK11.40792604
32PIM11.40343549
33BCKDK1.32551541
34CSF1R1.30925807
35IRAK21.29805579
36ERBB41.27285454
37ARAF1.23218054
38EIF2AK21.22705512
39LYN1.22542770
40ABL21.20708694
41MAP3K51.17511097
42HCK1.17460991
43SYK1.16010306
44BTK1.13785607
45TAOK31.05974913
46CDC42BPA1.01644527
47SIK30.99573200
48MAP2K30.98428955
49LATS20.94634224
50TESK10.93781987
51ERN10.93603503
52TEC0.92896669
53IRAK10.91948496
54KIT0.89226001
55ZAP700.88781215
56ERBB30.88383702
57JAK20.87088638
58LCK0.83821446
59TGFBR20.82555072
60NME20.81721834
61PRKCD0.81382143
62CLK10.80698364
63MATK0.80010138
64MAPK110.79829082
65MST40.76633540
66EPHB20.76496391
67TRPM70.75808173
68ABL10.75608118
69NEK90.75332052
70MAP3K120.73278566
71STK100.72419050
72TYRO30.67468148
73TESK20.67000516
74MST1R0.63432611
75DAPK30.62931815
76HIPK20.60521710
77FES0.59852246
78DYRK30.58078865
79YES10.56188178
80ACVR1B0.55498550
81EGFR0.53941281
82PRKCQ0.52487687
83TRIB30.50064216
84FYN0.49372983
85ADRBK10.49156893
86ITK0.43975833
87EPHA30.43752553
88INSR0.42541742
89LRRK20.41840080
90STK30.41191232
91PTK60.38757526
92PLK20.37936767
93PRKCH0.37930762
94IGF1R0.37921252
95MUSK0.36731834
96PRKCG0.35790989
97KSR20.34197591
98STK40.33461422
99PRKCE0.32549794
100PDGFRA0.30644504
101MAP2K60.29990860
102TNK20.28045228
103STK240.27451240
104MAPK70.27366411
105MOS0.27121194
106RPS6KA50.26199375
107SIK10.25309907
108CAMK2G0.21518090
109MARK30.20682265
110CDK40.20327782
111SRC0.19930750
112FGFR10.19092493
113PDK10.18991194
114ICK0.18739853
115MAP3K10.16598588
116MAP3K80.16436869
117CDK60.16156633
118PKN10.16131408
119PRKACG0.15361726
120PRKCA0.15157350
121DAPK20.14527003
122TTN0.14337449
123MAPKAPK20.13342303
124SGK10.13252747
125SIK20.12558657
126CDK90.11838455
127TAOK20.11534791
128MAPK30.11355425
129BMPR1B0.11228570
130PIK3CG0.11005658
131PRKG20.10492259
132MAPK40.09804062
133PRKCB0.09791596
134CDK140.09559823
135EPHB10.09295035
136PAK40.09232821
137BRAF0.08531430
138CAMK2A0.08194316
139RPS6KA10.08138002
140CDK150.06194386

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053326.37763479
2Type I diabetes mellitus_Homo sapiens_hsa049404.38809542
3Rheumatoid arthritis_Homo sapiens_hsa053233.39131191
4Leishmaniasis_Homo sapiens_hsa051403.27738583
5Legionellosis_Homo sapiens_hsa051343.27112062
6Allograft rejection_Homo sapiens_hsa053303.20561997
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.99649549
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.99424921
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.78861957
10* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.76442059
11Pertussis_Homo sapiens_hsa051332.71696894
12Salmonella infection_Homo sapiens_hsa051322.62258320
13Staphylococcus aureus infection_Homo sapiens_hsa051502.46208159
14* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.45953242
15Malaria_Homo sapiens_hsa051442.36884695
16TNF signaling pathway_Homo sapiens_hsa046682.04985360
17Hematopoietic cell lineage_Homo sapiens_hsa046402.04869021
18* Tuberculosis_Homo sapiens_hsa051522.04230253
19African trypanosomiasis_Homo sapiens_hsa051432.03167333
20* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.91254465
21Asthma_Homo sapiens_hsa053101.87274030
22Prion diseases_Homo sapiens_hsa050201.85657931
23* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.74507813
24Autoimmune thyroid disease_Homo sapiens_hsa053201.69730716
25* Osteoclast differentiation_Homo sapiens_hsa043801.65957037
26* Measles_Homo sapiens_hsa051621.59550377
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.51843093
28* Influenza A_Homo sapiens_hsa051641.35359290
29* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28984899
30Amoebiasis_Homo sapiens_hsa051461.24967808
31Chemokine signaling pathway_Homo sapiens_hsa040621.22148184
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15947308
33Phagosome_Homo sapiens_hsa041451.10777928
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.08633617
35* Herpes simplex infection_Homo sapiens_hsa051680.94853749
36* Jak-STAT signaling pathway_Homo sapiens_hsa046300.94420985
37Complement and coagulation cascades_Homo sapiens_hsa046100.85475701
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83304455
39Viral myocarditis_Homo sapiens_hsa054160.82983245
40Epstein-Barr virus infection_Homo sapiens_hsa051690.82756808
41Toxoplasmosis_Homo sapiens_hsa051450.81327147
42Shigellosis_Homo sapiens_hsa051310.69383086
43Lysosome_Homo sapiens_hsa041420.67617749
44Bladder cancer_Homo sapiens_hsa052190.65417134
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63382422
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62934478
47* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62421369
48* Hepatitis B_Homo sapiens_hsa051610.60262279
49Collecting duct acid secretion_Homo sapiens_hsa049660.59247432
50Apoptosis_Homo sapiens_hsa042100.58691020
51B cell receptor signaling pathway_Homo sapiens_hsa046620.56657744
52Sphingolipid metabolism_Homo sapiens_hsa006000.51659890
53* Hepatitis C_Homo sapiens_hsa051600.50746820
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46287065
55HTLV-I infection_Homo sapiens_hsa051660.44184479
56Type II diabetes mellitus_Homo sapiens_hsa049300.44042751
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.42721085
58T cell receptor signaling pathway_Homo sapiens_hsa046600.40094487
59Viral carcinogenesis_Homo sapiens_hsa052030.39098644
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33953915
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32753771
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31151481
63Antigen processing and presentation_Homo sapiens_hsa046120.29629220
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28679500
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25778090
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24750119
67Regulation of autophagy_Homo sapiens_hsa041400.21819542
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.20694217
69Steroid biosynthesis_Homo sapiens_hsa001000.20302625
70Other glycan degradation_Homo sapiens_hsa005110.20002668
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19856241
72FoxO signaling pathway_Homo sapiens_hsa040680.19829757
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19442504
74Tryptophan metabolism_Homo sapiens_hsa003800.18972838
75Platelet activation_Homo sapiens_hsa046110.18138344
76Mineral absorption_Homo sapiens_hsa049780.17105667
77MAPK signaling pathway_Homo sapiens_hsa040100.16307024
78Histidine metabolism_Homo sapiens_hsa003400.14710687
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.14669443
80Synaptic vesicle cycle_Homo sapiens_hsa047210.13326859
81Dorso-ventral axis formation_Homo sapiens_hsa043200.12487373
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.12146587
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11885354
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11086140
85Primary immunodeficiency_Homo sapiens_hsa053400.09996783
86Acute myeloid leukemia_Homo sapiens_hsa052210.09409403
87Notch signaling pathway_Homo sapiens_hsa043300.09310088
88Proteoglycans in cancer_Homo sapiens_hsa052050.08553897
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07650961
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.07508585
91HIF-1 signaling pathway_Homo sapiens_hsa040660.07076867
92Small cell lung cancer_Homo sapiens_hsa052220.06929581
93Vibrio cholerae infection_Homo sapiens_hsa051100.06402670
94Endocytosis_Homo sapiens_hsa041440.06397226
95mTOR signaling pathway_Homo sapiens_hsa041500.06316181
96Prostate cancer_Homo sapiens_hsa052150.04681341
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.04493353
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.04095636
99Vitamin digestion and absorption_Homo sapiens_hsa049770.02744809
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02229025
101Renal cell carcinoma_Homo sapiens_hsa052110.02098339
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.01939857
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.01800882
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.01719241
105Galactose metabolism_Homo sapiens_hsa000520.01547447
106Systemic lupus erythematosus_Homo sapiens_hsa053220.01446464
107VEGF signaling pathway_Homo sapiens_hsa043700.01000923
108Chronic myeloid leukemia_Homo sapiens_hsa052200.00570276
109Arachidonic acid metabolism_Homo sapiens_hsa005900.00439989
110Rap1 signaling pathway_Homo sapiens_hsa04015-0.0574356
111Arginine biosynthesis_Homo sapiens_hsa00220-0.0410827
112Folate biosynthesis_Homo sapiens_hsa00790-0.0333340
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400-0.0282333
114Insulin resistance_Homo sapiens_hsa04931-0.0224663
115Pentose and glucuronate interconversions_Homo sapiens_hsa00040-0.0210407
116Sulfur metabolism_Homo sapiens_hsa00920-0.0176096
117Pancreatic cancer_Homo sapiens_hsa05212-0.0117815
118Transcriptional misregulation in cancer_Homo sapiens_hsa05202-0.0037100
119Prolactin signaling pathway_Homo sapiens_hsa04917-0.0011307

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