IFNGR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-12 production (GO:0032695)5.01100885
2detection of molecule of bacterial origin (GO:0032490)4.40708802
3positive regulation of gamma-delta T cell activation (GO:0046645)4.40407639
4negative regulation of cell killing (GO:0031342)4.39892578
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.39892578
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.36921720
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.36921720
8modulation by symbiont of host immune response (GO:0052553)4.36921720
9positive regulation by symbiont of host defense response (GO:0052509)4.36921720
10modulation by symbiont of host defense response (GO:0052031)4.36921720
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.36921720
12detection of other organism (GO:0098543)4.30698897
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.14811242
14sarcomere organization (GO:0045214)4.06664998
15detection of external biotic stimulus (GO:0098581)4.00858453
16detection of bacterium (GO:0016045)3.98711825
17regulation of interferon-beta biosynthetic process (GO:0045357)3.79627266
18neutrophil activation involved in immune response (GO:0002283)3.65744066
19positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.64718496
20macrophage activation involved in immune response (GO:0002281)3.63896208
21T-helper 1 type immune response (GO:0042088)3.58890059
22regulation of relaxation of muscle (GO:1901077)3.54088772
23detection of biotic stimulus (GO:0009595)3.53661740
24positive regulation of interferon-alpha production (GO:0032727)3.46014947
25response to host immune response (GO:0052572)3.43926278
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.43926278
27response to peptidoglycan (GO:0032494)3.42799637
28cardiac myofibril assembly (GO:0055003)3.37245899
29cellular response to zinc ion (GO:0071294)3.36587166
30regulation of mast cell degranulation (GO:0043304)3.36078630
31regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.35440113
32regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.28991086
33NIK/NF-kappaB signaling (GO:0038061)3.25478410
34regulation of interferon-alpha production (GO:0032647)3.25441308
35germinal center formation (GO:0002467)3.21973116
36microglial cell activation (GO:0001774)3.21342997
37positive regulation of antigen processing and presentation (GO:0002579)3.20359821
38regulation of dendritic cell antigen processing and presentation (GO:0002604)3.17054934
39response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.16136513
40response to host (GO:0075136)3.16136513
41response to host defenses (GO:0052200)3.16136513
42myofibril assembly (GO:0030239)3.15865153
43negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.15224074
44positive regulation of mast cell activation (GO:0033005)3.14152634
45regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.14052500
46respiratory burst (GO:0045730)3.08756421
47regulation of mast cell activation involved in immune response (GO:0033006)3.08110730
48immunoglobulin mediated immune response (GO:0016064)3.07753904
49leukocyte aggregation (GO:0070486)3.06732947
50regulation of gamma-delta T cell activation (GO:0046643)3.05779268
51regulation of leukocyte degranulation (GO:0043300)3.04900410
52regulation of T-helper 2 cell differentiation (GO:0045628)3.03537685
53regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03149735
54regulation of cell communication by electrical coupling (GO:0010649)3.02982665
55B cell mediated immunity (GO:0019724)3.02546798
56defense response to protozoan (GO:0042832)3.00567696
57bundle of His cell to Purkinje myocyte communication (GO:0086069)3.00548057
58glycosphingolipid catabolic process (GO:0046479)2.98827285
59regulation of actin filament-based movement (GO:1903115)2.98686190
60negative regulation of cytokine production involved in immune response (GO:0002719)2.98530517
61regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.96548621
62positive regulation of mast cell activation involved in immune response (GO:0033008)2.96141902
63positive regulation of mast cell degranulation (GO:0043306)2.96141902
64production of molecular mediator involved in inflammatory response (GO:0002532)2.93802125
65antigen processing and presentation of endogenous antigen (GO:0019883)2.91359885
66negative regulation of erythrocyte differentiation (GO:0045647)2.91083955
67regulation of mast cell activation (GO:0033003)2.89113198
68response to protozoan (GO:0001562)2.87552854
69cytidine metabolic process (GO:0046087)2.87545838
70cytidine catabolic process (GO:0006216)2.87545838
71cytidine deamination (GO:0009972)2.87545838
72cellular response to thyroid hormone stimulus (GO:0097067)2.85342982
73positive regulation of leukocyte degranulation (GO:0043302)2.85041603
74regulation of podosome assembly (GO:0071801)2.83172943
75lipopolysaccharide-mediated signaling pathway (GO:0031663)2.83161784
76positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.81394363
77positive regulation of toll-like receptor signaling pathway (GO:0034123)2.80758344
78Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80237677
79regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.79307298
80regulation of T cell tolerance induction (GO:0002664)2.78862226
81granulocyte activation (GO:0036230)2.78737844
82neutrophil activation (GO:0042119)2.78647472
83regulation of interleukin-12 biosynthetic process (GO:0045075)2.78542046
84positive regulation of type 2 immune response (GO:0002830)2.78445335
85striated muscle atrophy (GO:0014891)2.78052991
86positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.77839767
87cellular extravasation (GO:0045123)2.77796735
88heart contraction (GO:0060047)2.77702402
89heart process (GO:0003015)2.77702402
90regulation of antigen processing and presentation (GO:0002577)2.76082155
91muscle filament sliding (GO:0030049)2.75574225
92actin-myosin filament sliding (GO:0033275)2.75574225
93regulation of vitamin D biosynthetic process (GO:0060556)2.75355090
94neutrophil mediated immunity (GO:0002446)2.74784271
95positive regulation of cellular amide metabolic process (GO:0034250)2.74595567
96macrophage activation (GO:0042116)2.73922857
97regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.73881794
98glycolipid catabolic process (GO:0019377)2.73565461
99amino sugar catabolic process (GO:0046348)2.71348667
100regulation of interleukin-8 biosynthetic process (GO:0045414)2.71290719
101myeloid dendritic cell activation (GO:0001773)2.70685414
102regulation of skeletal muscle contraction (GO:0014819)2.70466761
103relaxation of cardiac muscle (GO:0055119)2.70331678
104positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.70280277
105neutrophil chemotaxis (GO:0030593)2.70178319
106oligosaccharide catabolic process (GO:0009313)2.70060438
107positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.68117112
108cardiac muscle contraction (GO:0060048)2.67381678
109myeloid leukocyte activation (GO:0002274)2.67240749
110* interferon-gamma-mediated signaling pathway (GO:0060333)2.66358781
111negative regulation of potassium ion transmembrane transport (GO:1901380)2.66292254
112regulation of tolerance induction (GO:0002643)2.66132888
113regulation of B cell receptor signaling pathway (GO:0050855)2.65667493
114leukocyte migration involved in inflammatory response (GO:0002523)2.64934755
115pyrimidine ribonucleoside catabolic process (GO:0046133)2.64483082
116positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.64383565
117plasma membrane repair (GO:0001778)2.64295137
118negative regulation of lymphocyte mediated immunity (GO:0002707)2.64191044
119antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.62898107
120antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.62898107
121positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.62874559
122positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.61901135
123hydrogen peroxide biosynthetic process (GO:0050665)2.60711768
124skeletal muscle adaptation (GO:0043501)2.57822603
125actomyosin structure organization (GO:0031032)2.57619490
126response to type I interferon (GO:0034340)2.56744242
127myeloid cell activation involved in immune response (GO:0002275)2.54280170
128positive regulation of natural killer cell differentiation (GO:0032825)2.54256774
129cellular response to type I interferon (GO:0071357)2.53972806
130type I interferon signaling pathway (GO:0060337)2.53972806
131lymphocyte chemotaxis (GO:0048247)2.53211500
132negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.50814706
133ventricular cardiac muscle cell action potential (GO:0086005)2.50273848
134positive regulation of monocyte chemotaxis (GO:0090026)2.48646984
135positive regulation of macrophage cytokine production (GO:0060907)2.48501713
136superoxide anion generation (GO:0042554)2.47447075
137response to muramyl dipeptide (GO:0032495)2.45922624
138cell adhesion mediated by integrin (GO:0033627)2.42527842
139regulation of cardiac muscle cell contraction (GO:0086004)2.42117836
140regulation of monocyte chemotaxis (GO:0090025)2.41165571
141sarcoplasmic reticulum calcium ion transport (GO:0070296)2.39481748
142reactive oxygen species biosynthetic process (GO:1903409)2.39245756
143muscle hypertrophy (GO:0014896)2.38195992
144positive regulation of chemokine biosynthetic process (GO:0045080)2.38110293
145pinocytosis (GO:0006907)2.37996835
146regulation of striated muscle contraction (GO:0006942)2.37477548
147regulation of mononuclear cell migration (GO:0071675)2.35826202
148regulation of macrophage cytokine production (GO:0010935)2.35215100
149positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.34190102
150regulation of sarcomere organization (GO:0060297)2.33291301
151positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.33267148
152myeloid dendritic cell differentiation (GO:0043011)2.32445896
153actin nucleation (GO:0045010)2.32265039
154actin-mediated cell contraction (GO:0070252)2.31976387
155I-kappaB phosphorylation (GO:0007252)2.30239081
156dendritic cell chemotaxis (GO:0002407)2.30218171

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.25373318
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.23408289
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.14283389
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.19516202
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01031431
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75312726
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.70398539
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.68453650
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.68088057
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.54464260
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.52067717
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.49319521
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.42090921
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39275352
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30648503
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.20853622
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18462995
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.16391371
19* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.11029018
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04118399
21* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01526799
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95774783
23GATA2_21666600_ChIP-Seq_HMVEC_Human1.91033138
24* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.89167199
25VDR_24787735_ChIP-Seq_THP-1_Human1.78960839
26SPI1_23127762_ChIP-Seq_K562_Human1.72792546
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67566554
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67380752
29* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64807062
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.61514667
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.61448692
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55154584
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53837325
34CDX2_20551321_ChIP-Seq_CACO-2_Human1.48485869
35VDR_24763502_ChIP-Seq_THP-1_Human1.47682599
36EGR1_19032775_ChIP-ChIP_M12_Human1.46504618
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.46208700
38SOX2_20726797_ChIP-Seq_SW620_Human1.45227525
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45223823
40RUNX_20019798_ChIP-Seq_JUKART_Human1.44687647
41* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39845591
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39251892
43UTX_26944678_Chip-Seq_JUKART_Human1.38865988
44TBX20_22328084_ChIP-Seq_HEART_Mouse1.38240936
45TBX20_22080862_ChIP-Seq_HEART_Mouse1.38240936
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37868833
47MYC_22102868_ChIP-Seq_BL_Human1.35425621
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33696461
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33143752
50PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32381615
51CJUN_26792858_Chip-Seq_BT549_Human1.31193501
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31193025
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31022354
54* GATA1_19941827_ChIP-Seq_MEL_Mouse1.30243736
55MYB_26560356_Chip-Seq_TH1_Human1.29460803
56* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28934870
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28665344
58PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27280596
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27132923
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27132923
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26666753
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25383879
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24867691
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23413164
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22433241
66CLOCK_20551151_ChIP-Seq_293T_Human1.21934505
67* PU_27001747_Chip-Seq_BMDM_Mouse1.20989483
68* CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20656702
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20602061
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20529848
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19641191
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17032002
73MAF_26560356_Chip-Seq_TH1_Human1.16947778
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.16270521
75MAF_26560356_Chip-Seq_TH2_Human1.15836785
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.15782418
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14424241
78* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14381091
79* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13026027
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12913470
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11071500
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09883413
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09883413
84* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09773752
85* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09468095
86VDR_21846776_ChIP-Seq_THP-1_Human1.08989115
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.08112161
88* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08034362
89* SPI1_23547873_ChIP-Seq_NB4_Human1.06251312
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05785036
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04619566
92GATA3_27048872_Chip-Seq_THYMUS_Human1.04572834
93* RUNX1_22412390_ChIP-Seq_EML_Mouse1.04423257
94* GATA2_19941826_ChIP-Seq_K562_Human1.03993279
95GATA1_19941826_ChIP-Seq_K562_Human1.03509102
96RXR_22158963_ChIP-Seq_LIVER_Mouse1.01367152
97TFEB_21752829_ChIP-Seq_HELA_Human1.00006786
98* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99864207
99* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99834185
100* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99518804
101LXR_22292898_ChIP-Seq_THP-1_Human0.97374277
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97120685
103ESR1_21235772_ChIP-Seq_MCF-7_Human0.96769210
104MYB_26560356_Chip-Seq_TH2_Human0.96318891
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96232709
106BCL6_27268052_Chip-Seq_Bcells_Human0.96116005
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95830424
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95484701
109PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95366924
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95058666
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94193867
112PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93682532
113* TCF7_22412390_ChIP-Seq_EML_Mouse0.93662086
114E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93634993
115GATA1_22025678_ChIP-Seq_K562_Human0.92856863
116* RACK7_27058665_Chip-Seq_MCF-7_Human0.92639242
117* KDM2B_26808549_Chip-Seq_DND41_Human0.92448948
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91633806
119BCOR_27268052_Chip-Seq_Bcells_Human0.90965937
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90058305
121* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89900542
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89203356
123* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88929942
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88896692
125* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88359287
126SCL_19346495_ChIP-Seq_HPC-7_Human0.85813796
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.85536477
128* GATA3_26560356_Chip-Seq_TH2_Human0.84900299
129MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.84448302
130* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84225132
131P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84205811
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83948605
133SMC1_22415368_ChIP-Seq_MEFs_Mouse0.81779084
134* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81559747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis3.53316392
2MP0001835_abnormal_antigen_presentation3.13466346
3MP0002837_dystrophic_cardiac_calcinosis3.10986456
4MP0003303_peritoneal_inflammation2.88179861
5MP0004084_abnormal_cardiac_muscle2.87122316
6MP0003436_decreased_susceptibility_to2.75735287
7MP0003646_muscle_fatigue2.66959305
8MP0009785_altered_susceptibility_to2.64122793
9* MP0002148_abnormal_hypersensitivity_rea2.60234809
10MP0003828_pulmonary_edema2.52217967
11MP0000343_altered_response_to2.29317592
12MP0000751_myopathy2.26304672
13MP0002419_abnormal_innate_immunity2.23429113
14MP0004215_abnormal_myocardial_fiber2.08377802
15MP0005058_abnormal_lysosome_morphology2.07158135
16MP0002972_abnormal_cardiac_muscle2.01501243
17MP0003300_gastrointestinal_ulcer1.96801187
18* MP0005000_abnormal_immune_tolerance1.95041448
19MP0005451_abnormal_body_composition1.91487145
20* MP0005025_abnormal_response_to1.89811887
21MP0004036_abnormal_muscle_relaxation1.86877837
22MP0001790_abnormal_immune_system1.86678716
23MP0005387_immune_system_phenotype1.86678716
24MP0005330_cardiomyopathy1.85401049
25MP0000685_abnormal_immune_system1.84187928
26MP0003191_abnormal_cellular_cholesterol1.80204374
27MP0006082_CNS_inflammation1.79694675
28* MP0002452_abnormal_antigen_presenting1.75304307
29MP0003724_increased_susceptibility_to1.71312566
30MP0008260_abnormal_autophagy1.69874450
31MP0000749_muscle_degeneration1.66899619
32MP0001533_abnormal_skeleton_physiology1.64875429
33MP0004484_altered_response_of1.64246025
34MP0004130_abnormal_muscle_cell1.61787602
35MP0005385_cardiovascular_system_phenoty1.61150951
36MP0001544_abnormal_cardiovascular_syste1.61150951
37MP0010155_abnormal_intestine_physiology1.60868193
38MP0008438_abnormal_cutaneous_collagen1.60771505
39MP0009840_abnormal_foam_cell1.59107445
40MP0004087_abnormal_muscle_fiber1.58981533
41MP0001853_heart_inflammation1.58976804
42MP0001800_abnormal_humoral_immune1.56953607
43MP0008775_abnormal_heart_ventricle1.53925084
44MP0002723_abnormal_immune_serum1.49268773
45MP0001545_abnormal_hematopoietic_system1.47471832
46MP0005397_hematopoietic_system_phenotyp1.47471832
47MP0002166_altered_tumor_susceptibility1.44024362
48MP0010630_abnormal_cardiac_muscle1.42859307
49MP0002139_abnormal_hepatobiliary_system1.42360644
50MP0003279_aneurysm1.42324122
51* MP0001819_abnormal_immune_cell1.41444592
52MP0005671_abnormal_response_to1.40842549
53MP0005620_abnormal_muscle_contractility1.39067845
54* MP0002420_abnormal_adaptive_immunity1.38393249
55MP0009764_decreased_sensitivity_to1.36057970
56MP0008004_abnormal_stomach_pH1.35630251
57MP0000750_abnormal_muscle_regeneration1.34770021
58MP0002138_abnormal_hepatobiliary_system1.34416331
59MP0005464_abnormal_platelet_physiology1.32637867
60MP0001845_abnormal_inflammatory_respons1.32386240
61MP0003690_abnormal_glial_cell1.30883370
62MP0009333_abnormal_splenocyte_physiolog1.30194266
63MP0003566_abnormal_cell_adhesion1.29415286
64MP0006138_congestive_heart_failure1.28123318
65MP0003806_abnormal_nucleotide_metabolis1.27081306
66MP0000465_gastrointestinal_hemorrhage1.26807014
67MP0003705_abnormal_hypodermis_morpholog1.26137177
68MP0005310_abnormal_salivary_gland1.26056101
69MP0002405_respiratory_system_inflammati1.23885663
70MP0003075_altered_response_to1.23773453
71MP0002998_abnormal_bone_remodeling1.23472456
72MP0002006_tumorigenesis1.22589727
73MP0004947_skin_inflammation1.22519131
74MP0005166_decreased_susceptibility_to1.22490016
75MP0003172_abnormal_lysosome_physiology1.21811555
76MP0003453_abnormal_keratinocyte_physiol1.21740444
77MP0000604_amyloidosis1.20945087
78MP0002106_abnormal_muscle_physiology1.18164180
79MP0002254_reproductive_system_inflammat1.18004331
80MP0003221_abnormal_cardiomyocyte_apopto1.17973585
81* MP0002398_abnormal_bone_marrow1.16528565
82MP0008469_abnormal_protein_level1.16429430
83MP0003448_altered_tumor_morphology1.13525936
84MP0001958_emphysema1.12344481
85MP0005167_abnormal_blood-brain_barrier1.10684791
86MP0003045_fibrosis1.08168938
87MP0003137_abnormal_impulse_conducting1.07743519
88MP0005165_increased_susceptibility_to1.06501377
89MP0003183_abnormal_peptide_metabolism1.05438334
90MP0000689_abnormal_spleen_morphology1.05354026
91* MP0002429_abnormal_blood_cell1.04753075
92MP0000767_abnormal_smooth_muscle1.04170796
93MP0003656_abnormal_erythrocyte_physiolo1.02690849
94MP0000249_abnormal_blood_vessel1.00463069
95MP0004858_abnormal_nervous_system0.99239961
96MP0006054_spinal_hemorrhage0.98847601
97MP0002277_abnormal_respiratory_mucosa0.98077297
98MP0000858_altered_metastatic_potential0.98074620
99MP0001879_abnormal_lymphatic_vessel0.97738331
100MP0002722_abnormal_immune_system0.97478369
101MP0003866_abnormal_defecation0.96611717
102MP0003091_abnormal_cell_migration0.93325523
103MP0004782_abnormal_surfactant_physiolog0.92611996
104MP0009763_increased_sensitivity_to0.92158061
105MP0001663_abnormal_digestive_system0.90673578
106MP0009278_abnormal_bone_marrow0.90612127
107MP0003329_amyloid_beta_deposits0.87494216
108MP0003763_abnormal_thymus_physiology0.86769245
109MP0001851_eye_inflammation0.85833323
110* MP0000716_abnormal_immune_system0.85089982
111MP0003795_abnormal_bone_structure0.83394718
112MP0005164_abnormal_response_to0.82214338
113MP0002877_abnormal_melanocyte_morpholog0.80823250
114MP0002132_abnormal_respiratory_system0.80785998
115MP0005275_abnormal_skin_tensile0.80599452
116MP0001873_stomach_inflammation0.79692076
117MP0000759_abnormal_skeletal_muscle0.79200328
118MP0005369_muscle_phenotype0.79179553
119MP0000920_abnormal_myelination0.79030514
120MP0002332_abnormal_exercise_endurance0.78875878
121MP0010234_abnormal_vibrissa_follicle0.78260641
122MP0010368_abnormal_lymphatic_system0.77496471
123MP0004883_abnormal_blood_vessel0.76000210
124MP0005023_abnormal_wound_healing0.75907363
125MP0004085_abnormal_heartbeat0.75004938
126MP0009765_abnormal_xenobiotic_induced0.74538436
127MP0005390_skeleton_phenotype0.73550458
128MP0001542_abnormal_bone_strength0.72467731
129MP0002933_joint_inflammation0.63986623
130MP0008874_decreased_physiological_sensi0.63870049
131MP0000609_abnormal_liver_physiology0.61578087
132MP0000490_abnormal_crypts_of0.61524943
133MP0005319_abnormal_enzyme/_coenzyme0.60544622
134MP0000371_diluted_coat_color0.57315803

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.88993449
2Eczematoid dermatitis (HP:0000976)4.79082564
3Sudden death (HP:0001699)4.66576729
4Ventricular tachycardia (HP:0004756)4.58452648
5Recurrent bacterial skin infections (HP:0005406)4.34697556
6Right ventricular cardiomyopathy (HP:0011663)4.26223972
7Loss of speech (HP:0002371)3.73603652
8Asymmetric septal hypertrophy (HP:0001670)3.54564559
9Exercise-induced muscle cramps (HP:0003710)3.54308920
10Atrial fibrillation (HP:0005110)3.53817591
11Recurrent gram-negative bacterial infections (HP:0005420)3.45351933
12Lipoatrophy (HP:0100578)3.44304830
13Systemic lupus erythematosus (HP:0002725)3.39815286
14Amyloidosis (HP:0011034)3.36267176
15Primary atrial arrhythmia (HP:0001692)3.36045210
16Syncope (HP:0001279)3.26423085
17Supraventricular tachycardia (HP:0004755)3.16313050
18Increased cerebral lipofuscin (HP:0011813)3.11520657
19Gingivitis (HP:0000230)3.11492678
20Supraventricular arrhythmia (HP:0005115)3.11025562
21Calf muscle hypertrophy (HP:0008981)3.09333189
22Keratoconjunctivitis sicca (HP:0001097)3.05942332
23Abnormality of macrophages (HP:0004311)3.05672859
24Palpitations (HP:0001962)2.92630822
25Vacuolated lymphocytes (HP:0001922)2.90180519
26Gastrointestinal infarctions (HP:0005244)2.88925123
27Abnormality of the calf musculature (HP:0001430)2.84927206
28Hematochezia (HP:0002573)2.80664128
29Meningitis (HP:0001287)2.79931458
30Autoimmune thrombocytopenia (HP:0001973)2.79660828
31Elevated erythrocyte sedimentation rate (HP:0003565)2.78602952
32Pulmonary infiltrates (HP:0002113)2.78178065
33Increased neuronal autofluorescent lipopigment (HP:0002074)2.75280716
34Keratoconjunctivitis (HP:0001096)2.75003679
35Muscle hypertrophy of the lower extremities (HP:0008968)2.74652923
36Myositis (HP:0100614)2.74169558
37EMG: myopathic abnormalities (HP:0003458)2.70515499
38Exercise-induced myalgia (HP:0003738)2.70204496
39Abnormality of the left ventricular outflow tract (HP:0011103)2.68795741
40Subaortic stenosis (HP:0001682)2.68795741
41Hemoptysis (HP:0002105)2.67819554
42Bundle branch block (HP:0011710)2.65251773
43Mediastinal lymphadenopathy (HP:0100721)2.63959631
44Mutism (HP:0002300)2.62857739
45Axonal loss (HP:0003447)2.62251107
46Ventricular arrhythmia (HP:0004308)2.60217053
47Pustule (HP:0200039)2.60044824
48Increased connective tissue (HP:0009025)2.57538703
49Dilated cardiomyopathy (HP:0001644)2.57367152
50Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.56894595
51Increased IgE level (HP:0003212)2.55989312
52Purpura (HP:0000979)2.54881457
53Petechiae (HP:0000967)2.53979989
54Recurrent skin infections (HP:0001581)2.51346886
55Malnutrition (HP:0004395)2.50963588
56Orchitis (HP:0100796)2.50858807
57Facial diplegia (HP:0001349)2.49660309
58Muscle fiber splitting (HP:0003555)2.48195819
59Recurrent fungal infections (HP:0002841)2.46485032
60Cellulitis (HP:0100658)2.45707324
61Neurofibrillary tangles (HP:0002185)2.43816790
62Prolonged QT interval (HP:0001657)2.42490386
63Increased serum ferritin (HP:0003281)2.41566806
64Encephalitis (HP:0002383)2.38780353
65Glomerulonephritis (HP:0000099)2.35076521
66Obstructive lung disease (HP:0006536)2.33504696
67Chronic obstructive pulmonary disease (HP:0006510)2.33504696
68Ventricular fibrillation (HP:0001663)2.32814843
69Hepatosplenomegaly (HP:0001433)2.29381822
70Dysostosis multiplex (HP:0000943)2.27992136
71Hyporeflexia of lower limbs (HP:0002600)2.27451114
72Recurrent cutaneous fungal infections (HP:0011370)2.26937293
73Chronic mucocutaneous candidiasis (HP:0002728)2.26937293
74Progressive neurologic deterioration (HP:0002344)2.25903553
75Episodic fever (HP:0001954)2.24351101
76Interstitial pulmonary disease (HP:0006530)2.23370650
77Myoglobinuria (HP:0002913)2.23218513
78Urticaria (HP:0001025)2.21790806
79Periodontitis (HP:0000704)2.21531006
80Arterial thrombosis (HP:0004420)2.20821525
81Esophageal neoplasm (HP:0100751)2.18767124
82Neoplasm of head and neck (HP:0012288)2.18767124
83Upper motor neuron abnormality (HP:0002127)2.17824003
84Chest pain (HP:0100749)2.17291151
85Disinhibition (HP:0000734)2.16352795
86Vertebral compression fractures (HP:0002953)2.16260761
87Tetraparesis (HP:0002273)2.16048828
88Abnormality of the vasculature of the conjunctiva (HP:0008054)2.15357430
89Nephritis (HP:0000123)2.14453087
90Gangrene (HP:0100758)2.13836920
91Bone cyst (HP:0012062)2.12849146
92Premature loss of primary teeth (HP:0006323)2.12451026
93Abnormality of proline metabolism (HP:0010907)2.12114903
94Hydroxyprolinuria (HP:0003080)2.12114903
95Conjunctival hamartoma (HP:0100780)2.10714965
96Anorexia (HP:0002039)2.09851839
97Neuronal loss in central nervous system (HP:0002529)2.09049542
98Colitis (HP:0002583)2.07745650
99Spontaneous hematomas (HP:0007420)2.06713026
100Gingival bleeding (HP:0000225)2.05568053
101Abnormality of iron homeostasis (HP:0011031)2.04568603
102Pulmonary embolism (HP:0002204)2.04057352
103Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04050229
104Polyneuropathy (HP:0001271)2.03138715
105Distal lower limb muscle weakness (HP:0009053)2.01248339
106Thick nail (HP:0001805)1.99599525
107Inflammation of the large intestine (HP:0002037)1.99432983
108Pathologic fracture (HP:0002756)1.99033011
109Abnormality of glycolipid metabolism (HP:0010969)1.98283877
110Abnormality of liposaccharide metabolism (HP:0010968)1.98283877
111Abnormality of glycosphingolipid metabolism (HP:0004343)1.98283877
112Sudden cardiac death (HP:0001645)1.97823165
113Abnormal delayed hypersensitivity skin test (HP:0002963)1.97374939
114Glomerulopathy (HP:0100820)1.96990578
115Abnormal atrioventricular conduction (HP:0005150)1.96684364
116Abnormality of complement system (HP:0005339)1.95937017
117Diminished motivation (HP:0000745)1.95352123
118Optic neuritis (HP:0100653)1.95014471
119Retrobulbar optic neuritis (HP:0100654)1.95014471
120Abnormality of the pleura (HP:0002103)1.94929037
121Urinary glycosaminoglycan excretion (HP:0003541)1.93796386
122Mucopolysacchariduria (HP:0008155)1.93796386
123Osteomyelitis (HP:0002754)1.92741395
124Stomatitis (HP:0010280)1.92320116
125Basal ganglia calcification (HP:0002135)1.92226607
126Increased CSF protein (HP:0002922)1.91661297
127Leukocytosis (HP:0001974)1.91315070
128Heart block (HP:0012722)1.91137122
129Epistaxis (HP:0000421)1.90327285
130Apathy (HP:0000741)1.90216959
131Restrictive lung disease (HP:0002091)1.89463166
132Frequent falls (HP:0002359)1.89355903
133Vasculitis (HP:0002633)1.88998873
134Complement deficiency (HP:0004431)1.88995203
135Nuclear cataract (HP:0100018)1.88622064
136Myocardial infarction (HP:0001658)1.88084319
137Abnormal EKG (HP:0003115)1.86919025
138Hypergammaglobulinemia (HP:0010702)1.86409779
139Prolonged bleeding time (HP:0003010)1.86119006
140Peritonitis (HP:0002586)1.85254884
141Myotonia (HP:0002486)1.84723412
142Recurrent viral infections (HP:0004429)1.84161795
143Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80504693
144Abnormality of polysaccharide metabolism (HP:0011012)1.80504693
145Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80504693
146Gastrointestinal stroma tumor (HP:0100723)1.80410771
147Nausea (HP:0002018)1.80330528
148Cerebral aneurysm (HP:0004944)1.78091421
149Gastrointestinal inflammation (HP:0004386)1.77968005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.27622172
2LMTK23.04202571
3MAP3K142.90218399
4RIPK42.82015948
5BLK2.81203797
6MYLK2.66950238
7TBK12.66569324
8PRPF4B2.29410349
9TYK22.24552870
10DMPK2.13649233
11ERN12.13509495
12PKN22.10217466
13IRAK42.09291489
14IRAK32.02878866
15TRIB32.01120827
16TGFBR21.99086557
17PIK3CA1.97559932
18TAOK11.93200866
19NEK91.91658738
20RIPK11.83579082
21TAOK21.75233775
22IKBKE1.64853826
23PHKG21.63656687
24PHKG11.63656687
25GRK71.62517847
26KIT1.59331721
27PIM21.59085395
28JAK11.56599666
29STK241.44641044
30SIK31.44637016
31DDR21.42194651
32FRK1.39877063
33JAK31.36475533
34MAP4K11.30322384
35BMPR21.29710452
36IKBKB1.28666548
37EPHA31.24230107
38CDC42BPA1.21015565
39EPHB11.20791028
40KSR21.16538740
41OBSCN1.13443243
42TNK21.09391181
43TESK21.08106507
44TESK11.05847727
45TRPM71.05100314
46MOS1.03616022
47MATK1.00946761
48IRAK10.99122461
49MAP3K120.98262582
50CSK0.98051195
51SYK0.97847568
52MST1R0.97663293
53IRAK20.95869419
54ZAP700.94960166
55CHUK0.92096309
56MAP3K50.89104250
57TEC0.87923212
58PTK60.86583904
59ACVR1B0.86533801
60CSF1R0.85313461
61HCK0.84432723
62MAP2K30.84253636
63DAPK30.84164008
64PTK2B0.82636327
65PRKG20.82155642
66JAK20.77405204
67MST40.73407678
68MARK30.72699470
69ILK0.71758427
70YES10.71673892
71CAMKK20.70967178
72MAP3K110.69267062
73MAP3K20.66199819
74BTK0.64656859
75TXK0.64240007
76NME20.63889730
77KSR10.63293580
78EPHB20.63128737
79PRKD20.62470982
80MAP3K60.61908056
81ARAF0.61641700
82PDK20.61374607
83FGFR30.60954295
84TAOK30.60857218
85MARK20.60543596
86MAP3K100.60507158
87FGFR40.59419536
88PRKCD0.58438224
89FGR0.57967327
90LRRK20.57197933
91ERBB30.57067678
92PDK30.55947349
93PDK40.55947349
94MAPK120.55546069
95RPS6KA20.53109341
96LYN0.52923298
97MAP2K60.52509045
98FLT30.51987507
99MAP3K30.51408496
100STK100.50970130
101CAMK1D0.50707879
102ABL20.49618547
103MAPK70.48182746
104PIM10.47800256
105GRK60.47297266
106PAK30.47168526
107LCK0.47138593
108MAP2K20.46921896
109FES0.46490152
110BMX0.46261034
111MAP3K130.45926543
112ROCK10.45800632
113MAP3K10.45421680
114TIE10.45132276
115RPS6KA60.44157070
116PRKD10.44125007
117CAMK2D0.43753736
118CDK60.43123635
119FYN0.43044089
120NUAK10.42488204
121LIMK10.42401238
122PDPK10.41973637
123RPS6KC10.41857937
124RPS6KL10.41857937
125PAK40.41659494
126MAPKAPK20.40540073
127MAP3K70.39755769
128PDK10.38601437
129RAF10.37964356
130HIPK20.34389880
131DAPK20.33264210
132SGK30.32996609
133ABL10.32593328
134MAP3K80.31844194
135ITK0.30529603
136DYRK1B0.27907417
137MAPK40.27741087
138SIK10.27689838

Predicted pathways (KEGG)

RankGene SetZ-score
1* Leishmaniasis_Homo sapiens_hsa051402.52739309
2Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12821970
3* Osteoclast differentiation_Homo sapiens_hsa043802.08862328
4Viral myocarditis_Homo sapiens_hsa054161.97877059
5Autoimmune thyroid disease_Homo sapiens_hsa053201.96170032
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.90712537
7Pertussis_Homo sapiens_hsa051331.88621032
8Dilated cardiomyopathy_Homo sapiens_hsa054141.88256279
9Staphylococcus aureus infection_Homo sapiens_hsa051501.86251325
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81877177
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76440362
12Type I diabetes mellitus_Homo sapiens_hsa049401.74907477
13* Tuberculosis_Homo sapiens_hsa051521.73273420
14Legionellosis_Homo sapiens_hsa051341.67756450
15Cardiac muscle contraction_Homo sapiens_hsa042601.61216027
16* Salmonella infection_Homo sapiens_hsa051321.60498058
17* Toxoplasmosis_Homo sapiens_hsa051451.58949873
18Malaria_Homo sapiens_hsa051441.46972602
19TNF signaling pathway_Homo sapiens_hsa046681.43046764
20Lysosome_Homo sapiens_hsa041421.41786011
21B cell receptor signaling pathway_Homo sapiens_hsa046621.41738156
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.40825047
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.36419651
24Phagosome_Homo sapiens_hsa041451.32425861
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.31090541
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.29211259
27* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29110994
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26438769
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25184468
30Rheumatoid arthritis_Homo sapiens_hsa053231.24898189
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23358719
32* Influenza A_Homo sapiens_hsa051641.22612817
33Other glycan degradation_Homo sapiens_hsa005111.20438238
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19940595
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16224626
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15366432
37Shigellosis_Homo sapiens_hsa051311.13339083
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12823753
39Amoebiasis_Homo sapiens_hsa051461.10809890
40* Measles_Homo sapiens_hsa051621.10448467
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07884220
42Apoptosis_Homo sapiens_hsa042101.05852889
43Chemokine signaling pathway_Homo sapiens_hsa040621.05777276
44Mineral absorption_Homo sapiens_hsa049781.03641152
45Oxidative phosphorylation_Homo sapiens_hsa001901.03372441
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98084016
47Allograft rejection_Homo sapiens_hsa053300.96911838
48Alzheimers disease_Homo sapiens_hsa050100.96885121
49Parkinsons disease_Homo sapiens_hsa050120.96641324
50* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96620774
51Graft-versus-host disease_Homo sapiens_hsa053320.90691359
52African trypanosomiasis_Homo sapiens_hsa051430.89946019
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88681948
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88529398
55Hematopoietic cell lineage_Homo sapiens_hsa046400.88265249
56Platelet activation_Homo sapiens_hsa046110.86224687
57* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84694895
58Complement and coagulation cascades_Homo sapiens_hsa046100.82093466
59Starch and sucrose metabolism_Homo sapiens_hsa005000.81640981
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80976857
61Focal adhesion_Homo sapiens_hsa045100.79477902
62Asthma_Homo sapiens_hsa053100.79135428
63* Jak-STAT signaling pathway_Homo sapiens_hsa046300.78649287
64* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77091275
65Prion diseases_Homo sapiens_hsa050200.76740251
66Hepatitis C_Homo sapiens_hsa051600.76637690
67Bladder cancer_Homo sapiens_hsa052190.75991491
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75077667
69Hepatitis B_Homo sapiens_hsa051610.75058066
70* HIF-1 signaling pathway_Homo sapiens_hsa040660.74911030
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74651806
72Acute myeloid leukemia_Homo sapiens_hsa052210.74319333
73VEGF signaling pathway_Homo sapiens_hsa043700.72890402
74Antigen processing and presentation_Homo sapiens_hsa046120.72698529
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.72667309
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.71454722
77Chronic myeloid leukemia_Homo sapiens_hsa052200.71369551
78Galactose metabolism_Homo sapiens_hsa000520.70890984
79Collecting duct acid secretion_Homo sapiens_hsa049660.70503932
80Fatty acid degradation_Homo sapiens_hsa000710.70296605
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70114718
82Renin-angiotensin system_Homo sapiens_hsa046140.69337721
83Prolactin signaling pathway_Homo sapiens_hsa049170.67330902
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67144929
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66950232
86Type II diabetes mellitus_Homo sapiens_hsa049300.65726086
87Endocytosis_Homo sapiens_hsa041440.63964806
88Insulin resistance_Homo sapiens_hsa049310.63827601
89Pancreatic cancer_Homo sapiens_hsa052120.63740244
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63370663
91Caffeine metabolism_Homo sapiens_hsa002320.62831075
92Vibrio cholerae infection_Homo sapiens_hsa051100.62726545
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61722412
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61488939
95Adherens junction_Homo sapiens_hsa045200.60718997
96Proteoglycans in cancer_Homo sapiens_hsa052050.58980903
97Fat digestion and absorption_Homo sapiens_hsa049750.58607704
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57784852
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57008414
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56732601
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54260210
102Non-small cell lung cancer_Homo sapiens_hsa052230.54059002
103Epstein-Barr virus infection_Homo sapiens_hsa051690.53681165
104Sphingolipid metabolism_Homo sapiens_hsa006000.52917469
105Renal cell carcinoma_Homo sapiens_hsa052110.52751924
106Primary immunodeficiency_Homo sapiens_hsa053400.51062517
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48263515
108Small cell lung cancer_Homo sapiens_hsa052220.47577867
109* Herpes simplex infection_Homo sapiens_hsa051680.44175009
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43613624
111GnRH signaling pathway_Homo sapiens_hsa049120.43047019
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.42551745
113Insulin signaling pathway_Homo sapiens_hsa049100.41374893
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40773271
115Notch signaling pathway_Homo sapiens_hsa043300.40744344
116T cell receptor signaling pathway_Homo sapiens_hsa046600.40199617
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39213802
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.39066680
119PPAR signaling pathway_Homo sapiens_hsa033200.37188790
120Viral carcinogenesis_Homo sapiens_hsa052030.36566479
121HTLV-I infection_Homo sapiens_hsa051660.35262588
122FoxO signaling pathway_Homo sapiens_hsa040680.31530368
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30128175
124Fructose and mannose metabolism_Homo sapiens_hsa000510.29708480
125Sulfur metabolism_Homo sapiens_hsa009200.26549037
126mTOR signaling pathway_Homo sapiens_hsa041500.25639211

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