IFNK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.93275367
2regulation of response to osmotic stress (GO:0047484)7.92422102
3positive regulation of cellular amide metabolic process (GO:0034250)7.88032391
4keratinization (GO:0031424)7.87940578
5aminoglycoside antibiotic metabolic process (GO:0030647)7.19076073
6cytidine metabolic process (GO:0046087)6.93136182
7cytidine catabolic process (GO:0006216)6.93136182
8cytidine deamination (GO:0009972)6.93136182
9negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.68103346
10somite rostral/caudal axis specification (GO:0032525)6.51665335
11regulation of mammary gland epithelial cell proliferation (GO:0033599)6.43762022
12negative regulation of cell cycle G2/M phase transition (GO:1902750)5.95644838
13muscle organ morphogenesis (GO:0048644)5.94836106
14coenzyme catabolic process (GO:0009109)5.81657246
15negative regulation of epidermis development (GO:0045683)5.54896820
16response to dietary excess (GO:0002021)5.48973315
17maintenance of protein location in nucleus (GO:0051457)5.24488976
18detection of molecule of bacterial origin (GO:0032490)5.19198268
19negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.11442153
20protein localization to kinetochore (GO:0034501)5.11352815
21positive regulation of protein import into nucleus, translocation (GO:0033160)5.00707412
22regulation of telomere maintenance via telomerase (GO:0032210)4.97589875
23hormone catabolic process (GO:0042447)4.92080015
24quinone metabolic process (GO:1901661)4.89877348
25interferon-gamma production (GO:0032609)4.87004926
26nucleoside transmembrane transport (GO:1901642)4.83017539
27pyrimidine ribonucleoside catabolic process (GO:0046133)4.75849977
28positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.72184897
29regulation of cellular amide metabolic process (GO:0034248)4.63021613
30positive regulation of humoral immune response (GO:0002922)4.61372022
31positive regulation of gamma-delta T cell activation (GO:0046645)4.51458674
32microglial cell activation (GO:0001774)4.48507514
33notochord development (GO:0030903)4.46720874
34negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.44353257
35epoxygenase P450 pathway (GO:0019373)4.42891643
36regulation of nuclear cell cycle DNA replication (GO:0033262)4.38020483
37phenol-containing compound catabolic process (GO:0019336)4.35760001
38regulation of cilium movement (GO:0003352)4.34748007
39branching involved in mammary gland duct morphogenesis (GO:0060444)4.33430380
40omega-hydroxylase P450 pathway (GO:0097267)4.30969616
41* regulation of MHC class I biosynthetic process (GO:0045343)4.23502766
42neutrophil mediated immunity (GO:0002446)4.22218440
43establishment of skin barrier (GO:0061436)4.21513444
44negative regulation of telomerase activity (GO:0051974)4.18442705
45regulation of G0 to G1 transition (GO:0070316)4.03279734
46phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.97937750
47icosanoid secretion (GO:0032309)3.97366818
48arachidonic acid secretion (GO:0050482)3.97366818
49positive regulation by organism of defense response of other organism involved in symbiotic interact3.96952007
50modulation by symbiont of host immune response (GO:0052553)3.96952007
51positive regulation by symbiont of host defense response (GO:0052509)3.96952007
52modulation by symbiont of host defense response (GO:0052031)3.96952007
53modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.96952007
54modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.96952007
55regulation of B cell receptor signaling pathway (GO:0050855)3.95811910
56positive regulation of interleukin-8 secretion (GO:2000484)3.95231454
57negative regulation of epidermal cell differentiation (GO:0045605)3.94919815
58positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.94637035
59negative regulation of interleukin-17 production (GO:0032700)3.93957136
60keratinocyte proliferation (GO:0043616)3.91727625
61dendritic cell migration (GO:0036336)3.91586194
62regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.88556036
63rRNA transcription (GO:0009303)3.88144671
64ventricular system development (GO:0021591)3.82149947
65phenylpropanoid metabolic process (GO:0009698)3.81992134
66detection of external biotic stimulus (GO:0098581)3.80638558
67myeloid leukocyte mediated immunity (GO:0002444)3.80456335
68regulation of translation in response to stress (GO:0043555)3.77849095
69protein K11-linked deubiquitination (GO:0035871)3.74379696
70iron ion import (GO:0097286)3.74093254
71negative regulation of systemic arterial blood pressure (GO:0003085)3.70013954
72thyroid hormone generation (GO:0006590)3.69384950
73nucleoside transport (GO:0015858)3.66880504
74primitive streak formation (GO:0090009)3.66227130
75histone H4-K5 acetylation (GO:0043981)3.63060251
76histone H4-K8 acetylation (GO:0043982)3.63060251
77macrophage activation involved in immune response (GO:0002281)3.62952115
78ventricular trabecula myocardium morphogenesis (GO:0003222)3.60425561
79detection of other organism (GO:0098543)3.59547529
80macrophage activation (GO:0042116)3.58801142
81negative regulation of telomere maintenance (GO:0032205)3.57780238
82rRNA methylation (GO:0031167)3.57715442
83cellular response to ethanol (GO:0071361)3.56809129
84establishment of endothelial barrier (GO:0061028)3.54978191
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.51635556
86cofactor transport (GO:0051181)3.50984355
87transepithelial transport (GO:0070633)3.50417960
88mitochondrion distribution (GO:0048311)3.49760096
89xenobiotic catabolic process (GO:0042178)3.48853004
90regulation of water loss via skin (GO:0033561)3.44872803
91hepatocyte apoptotic process (GO:0097284)3.35986013
92histone H4-K12 acetylation (GO:0043983)3.35794990
93histone mRNA catabolic process (GO:0071044)3.34237954
94positive regulation of DNA-dependent DNA replication (GO:2000105)3.32008109
95cellular extravasation (GO:0045123)3.31032337
96cellular modified amino acid catabolic process (GO:0042219)3.31031448
97intestinal epithelial cell development (GO:0060576)3.30049678
98bone trabecula formation (GO:0060346)3.29282644
99regulation of apoptotic process involved in morphogenesis (GO:1902337)3.29249730
100histone H3-K36 demethylation (GO:0070544)3.28111445
101detection of biotic stimulus (GO:0009595)3.27638553
102chromatin assembly (GO:0031497)3.26796208
103trophectodermal cell differentiation (GO:0001829)3.25900716
104cofactor catabolic process (GO:0051187)3.25076628
105protein localization to chromosome, centromeric region (GO:0071459)3.23541061
106icosanoid transport (GO:0071715)3.23413025
107fatty acid derivative transport (GO:1901571)3.23413025
108cullin deneddylation (GO:0010388)3.21803998
109hypotonic response (GO:0006971)3.20873834
110regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.20402302
111protein K48-linked deubiquitination (GO:0071108)3.19156479
112regulation of gamma-delta T cell activation (GO:0046643)3.18245370
113dosage compensation (GO:0007549)3.16977088
114neutrophil activation involved in immune response (GO:0002283)3.16785558
115monoubiquitinated protein deubiquitination (GO:0035520)3.16729328
116regulation of transforming growth factor beta1 production (GO:0032908)3.16308841
117defense response to Gram-negative bacterium (GO:0050829)3.16000805
118rRNA modification (GO:0000154)3.15858681
119positive regulation of keratinocyte differentiation (GO:0045618)3.12979650
120regulation of gamma-delta T cell differentiation (GO:0045586)3.12141928
121negative regulation of cell killing (GO:0031342)3.11907033
122negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.11907033
123negative regulation of interleukin-12 production (GO:0032695)3.11738461
124positive regulation of insulin receptor signaling pathway (GO:0046628)3.11509812
125regulation of beta-amyloid formation (GO:1902003)3.11397385
126hair cycle (GO:0042633)3.09609761
127molting cycle (GO:0042303)3.09609761
128antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.07735433
129positive regulation of macrophage cytokine production (GO:0060907)3.07294514
130histone H3-K4 trimethylation (GO:0080182)3.06235686
131negative regulation of potassium ion transmembrane transport (GO:1901380)3.05518908
132L-ascorbic acid metabolic process (GO:0019852)3.04657520
133mitotic sister chromatid segregation (GO:0000070)3.03781584
134regulation of interferon-beta biosynthetic process (GO:0045357)3.01593813
135biotin metabolic process (GO:0006768)3.00475829
136early endosome to late endosome transport (GO:0045022)3.00350551
137DNA replication checkpoint (GO:0000076)2.99950962
138cell-substrate junction assembly (GO:0007044)2.99750260
139Rap protein signal transduction (GO:0032486)2.98635564
140negative regulation of B cell proliferation (GO:0030889)2.97442535
141desmosome organization (GO:0002934)2.96581540
142negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.96128863
143signal transduction involved in regulation of gene expression (GO:0023019)2.94400365
144vitamin A metabolic process (GO:0006776)2.93003141
145response to peptidoglycan (GO:0032494)2.92362313
146response to host immune response (GO:0052572)2.92017134
147response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.92017134
148regulation of interleukin-12 biosynthetic process (GO:0045075)2.89639596
149branching involved in labyrinthine layer morphogenesis (GO:0060670)2.89402641
150protein deneddylation (GO:0000338)2.88394178
151trabecula morphogenesis (GO:0061383)2.87345360
152negative regulation of T cell mediated immunity (GO:0002710)2.87067849
153cyclooxygenase pathway (GO:0019371)2.86635623
154positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.86504452
155mitotic G2/M transition checkpoint (GO:0044818)2.85559767
156heterochromatin organization (GO:0070828)2.84747088
157thyroid hormone metabolic process (GO:0042403)2.84130817
158regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.83348795
159embryonic process involved in female pregnancy (GO:0060136)2.82999397
160cell fate commitment involved in formation of primary germ layer (GO:0060795)2.81451284
161negative regulation of complement activation (GO:0045916)2.80610520
162B cell receptor signaling pathway (GO:0050853)2.80399796
163positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80021205
164detection of temperature stimulus (GO:0016048)2.79150072
165negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.77806111
166nuclear pore complex assembly (GO:0051292)2.76898509
167maintenance of protein localization in organelle (GO:0072595)2.76811037
168interleukin-6-mediated signaling pathway (GO:0070102)2.76614701
169protein K63-linked deubiquitination (GO:0070536)2.76133697
170necroptotic process (GO:0070266)2.75796500
171detection of bacterium (GO:0016045)2.75494627
172regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.74936985
173response to host (GO:0075136)2.71838292
174response to host defenses (GO:0052200)2.71838292
175response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.71838292
176nuclear pore organization (GO:0006999)2.71593541
177pore complex assembly (GO:0046931)2.69440002
178regulation of necroptotic process (GO:0060544)2.69418286
179keratinocyte differentiation (GO:0030216)2.68756310
180import into cell (GO:0098657)2.68289680
181positive regulation of p38MAPK cascade (GO:1900745)2.68082943
182negative regulation of lymphocyte mediated immunity (GO:0002707)2.64952668
183negative regulation of immunoglobulin mediated immune response (GO:0002890)2.64678295
184negative regulation of B cell mediated immunity (GO:0002713)2.64678295
185necrotic cell death (GO:0070265)2.64296291
186response to muramyl dipeptide (GO:0032495)2.63215539
187myeloid cell activation involved in immune response (GO:0002275)2.61777487
188regulation of interleukin-8 secretion (GO:2000482)2.60392809
189positive regulation of T-helper 1 type immune response (GO:0002827)2.59733957
190defense response to fungus (GO:0050832)2.56519124
191negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.53496025
192regulation of fibroblast apoptotic process (GO:2000269)2.50837025
193polyketide metabolic process (GO:0030638)11.3435279
194doxorubicin metabolic process (GO:0044598)11.3435279
195daunorubicin metabolic process (GO:0044597)11.3435279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.92034696
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.82798211
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.82798211
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.82798211
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.50884381
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.89856901
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.57886866
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.56096754
9SMAD_19615063_ChIP-ChIP_OVARY_Human3.39377075
10TP63_19390658_ChIP-ChIP_HaCaT_Human3.37062599
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.00759279
12TCF3_18692474_ChIP-Seq_MEFs_Mouse2.89673155
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.87325048
14TCF3_18692474_ChIP-Seq_MESCs_Mouse2.80798837
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.74718827
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.72027808
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.69722629
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.65151016
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.63438000
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.41056789
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.35421495
22E2F7_22180533_ChIP-Seq_HELA_Human2.34946187
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.34485463
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27690548
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26102240
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.22436864
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21867268
28NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.21693505
29GATA1_22025678_ChIP-Seq_K562_Human2.16661822
30HIF1A_21447827_ChIP-Seq_MCF-7_Human2.10391099
31IRF8_27001747_Chip-Seq_BMDM_Mouse2.09129575
32IRF8_21731497_ChIP-ChIP_J774_Mouse2.07732779
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07264339
34NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.94914783
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.93082302
36* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.92203643
37* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.92203643
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.86433251
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86194220
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84890796
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.82844208
42TP53_16413492_ChIP-PET_HCT116_Human1.82058011
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81882414
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81848665
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81574814
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79445720
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.77976326
48NANOG_18692474_ChIP-Seq_MEFs_Mouse1.77703093
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.76557017
50VDR_24787735_ChIP-Seq_THP-1_Human1.73602906
51RUNX_20019798_ChIP-Seq_JUKART_Human1.69594201
52* TP63_23658742_ChIP-Seq_EP156T_Human1.68978460
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.68143589
54NANOG_18692474_ChIP-Seq_MESCs_Mouse1.65960415
55TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.60870238
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60229123
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58632332
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56038959
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53309201
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50277403
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42037365
62SCL_19346495_ChIP-Seq_HPC-7_Human1.42034814
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.40478334
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40400831
65POU5F1_16518401_ChIP-PET_MESCs_Mouse1.40377813
66MYB_26560356_Chip-Seq_TH2_Human1.40207930
67PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.40047278
68FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.38422820
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36404026
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35821019
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35212846
72POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34149336
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32819612
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.31858934
75SOX2_18692474_ChIP-Seq_MEFs_Mouse1.31097531
76OCT4_18692474_ChIP-Seq_MEFs_Mouse1.30371067
77TAF15_26573619_Chip-Seq_HEK293_Human1.30341359
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30066291
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30024672
80E2F1_17053090_ChIP-ChIP_MCF-7_Human1.28622613
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27748442
82SOX2_18692474_ChIP-Seq_MESCs_Mouse1.26488306
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25201638
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.24786570
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.24260623
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23968782
87GATA3_26560356_Chip-Seq_TH2_Human1.23698708
88PU_27001747_Chip-Seq_BMDM_Mouse1.23061952
89NANOG_16518401_ChIP-PET_MESCs_Mouse1.22876611
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21754967
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.21117314
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20736844
93SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20185193
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19977363
95TP53_22127205_ChIP-Seq_IMR90_Human1.18894178
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18349108
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17835116
98EOMES_21245162_ChIP-Seq_HESCs_Human1.16818717
99* NANOG_18555785_Chip-Seq_ESCs_Mouse1.15455520
100CJUN_26792858_Chip-Seq_BT549_Human1.14853652
101BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14089674
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13216320
103GATA3_27048872_Chip-Seq_THYMUS_Human1.11112605
104IRF1_19129219_ChIP-ChIP_H3396_Human1.10715262
105CDX2_22108803_ChIP-Seq_LS180_Human1.09352027
106GATA2_19941826_ChIP-Seq_K562_Human1.08245909
107STAT3_23295773_ChIP-Seq_U87_Human1.08179807
108JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07958823
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07449696
110MYB_26560356_Chip-Seq_TH1_Human1.07306331
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.06840049
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06122603
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06103011
114FLI1_27457419_Chip-Seq_LIVER_Mouse1.05983956
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.05600196
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.05540296
117NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04970827
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04970827
119AHR_22903824_ChIP-Seq_MCF-7_Human1.04933376
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04920975
121E2F1_18555785_Chip-Seq_ESCs_Mouse1.04705813
122RXR_22108803_ChIP-Seq_LS180_Human1.04393210
123STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04269599
124P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03698560
125ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03409367
126ER_23166858_ChIP-Seq_MCF-7_Human1.02993602
127SPI1_23127762_ChIP-Seq_K562_Human1.02792706
128GATA2_21666600_ChIP-Seq_HMVEC_Human1.02090604
129RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01689085
130AR_21572438_ChIP-Seq_LNCaP_Human1.01226880
131OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01111147
132RNF2_27304074_Chip-Seq_NSC_Mouse1.01109027
133ARNT_22903824_ChIP-Seq_MCF-7_Human1.00905331
134MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00476543
135BRD4_25478319_ChIP-Seq_HGPS_Human1.00394487
136SMAD4_21799915_ChIP-Seq_A2780_Human1.00371007
137JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99517186
138PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99252304
139SPI1_23547873_ChIP-Seq_NB4_Human0.98647705
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.98220867
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98031389
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98031389
143SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97891416
144TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97702581
145GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97628911
146POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96667927
147CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96665487
148NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96318672
149CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95127470
150ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94859402
151* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94659219
152STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88684066
153SOX2_16153702_ChIP-ChIP_HESCs_Human0.86851452
154HOXB7_26014856_ChIP-Seq_BT474_Human0.83045975
155MYC_19030024_ChIP-ChIP_MESCs_Mouse0.81938092
156ELK1_22589737_ChIP-Seq_MCF10A_Human0.81751564
157TRIM28_21343339_ChIP-Seq_HEK293_Human0.81706047
158TBX3_20139965_ChIP-Seq_ESCs_Mouse0.79145579
159TBX3_20139965_ChIP-Seq_MESCs_Mouse0.78905700
160* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.78787607
161TP63_17297297_ChIP-ChIP_HaCaT_Human0.76019306
162KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.72452964
163RING1B_27294783_Chip-Seq_NPCs_Mouse0.71206627
164FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.70993210
165ESET_19884257_ChIP-Seq_ESCs_Mouse0.70893598
166ESR2_21235772_ChIP-Seq_MCF-7_Human0.68388534
167EGR1_19374776_ChIP-ChIP_THP-1_Human0.68190742
168ELF5_23300383_ChIP-Seq_T47D_Human0.67635461
169STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.67158704
170Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66733635
171GATA6_25053715_ChIP-Seq_YYC3_Human0.66375827
172TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.66124704
173STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.66029380
174TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.65123038
175RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.64872143
176NCOR1_26117541_ChIP-Seq_K562_Human0.63774727
177NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.62807261
178YY1_21170310_ChIP-Seq_MESCs_Mouse0.62505306
179GATA3_24758297_ChIP-Seq_MCF-7_Human0.61444606
180KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.61276463
181SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.60056879
182KAP1_27257070_Chip-Seq_ESCs_Mouse0.59812187
183CSB_26484114_Chip-Seq_FIBROBLAST_Human0.59195583
184IRF8_22096565_ChIP-ChIP_GC-B_Human0.59077949
185KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.59071956
186MYC_19079543_ChIP-ChIP_MESCs_Mouse0.57764875
187RACK7_27058665_Chip-Seq_MCF-7_Human0.54894486
188ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.53967396
189PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.53895363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.79672998
2MP0003011_delayed_dark_adaptation4.56604135
3MP0004264_abnormal_extraembryonic_tissu4.34144145
4MP0010234_abnormal_vibrissa_follicle4.07619395
5MP0005499_abnormal_olfactory_system3.91862234
6MP0005394_taste/olfaction_phenotype3.91862234
7MP0003890_abnormal_embryonic-extraembry3.78993000
8MP0004858_abnormal_nervous_system3.71158892
9MP0006292_abnormal_olfactory_placode3.36276139
10MP0008260_abnormal_autophagy3.26828218
11MP0002332_abnormal_exercise_endurance3.21675489
12MP0000579_abnormal_nail_morphology3.18583640
13MP0003122_maternal_imprinting3.00224860
14MP0005409_darkened_coat_color2.96538063
15MP0006082_CNS_inflammation2.94866591
16MP0002796_impaired_skin_barrier2.90062727
17MP0010352_gastrointestinal_tract_polyps2.80682081
18MP0003191_abnormal_cellular_cholesterol2.79625391
19MP0002254_reproductive_system_inflammat2.79281019
20MP0005275_abnormal_skin_tensile2.73856403
21MP0000678_abnormal_parathyroid_gland2.72189222
22MP0003724_increased_susceptibility_to2.54803345
23MP0002277_abnormal_respiratory_mucosa2.47677333
24MP0005075_abnormal_melanosome_morpholog2.46330123
25MP0005257_abnormal_intraocular_pressure2.45255371
26MP0000015_abnormal_ear_pigmentation2.27187840
27MP0005174_abnormal_tail_pigmentation2.19868435
28MP0006035_abnormal_mitochondrial_morpho2.15545689
29MP0000762_abnormal_tongue_morphology2.02252104
30MP0002060_abnormal_skin_morphology1.99324854
31MP0008057_abnormal_DNA_replication1.96491979
32MP0004947_skin_inflammation1.94621583
33MP0003121_genomic_imprinting1.94157784
34MP0001216_abnormal_epidermal_layer1.85830294
35MP0001835_abnormal_antigen_presentation1.84075041
36MP0003941_abnormal_skin_development1.79056059
37MP0004957_abnormal_blastocyst_morpholog1.77114575
38MP0003221_abnormal_cardiomyocyte_apopto1.75132394
39MP0003806_abnormal_nucleotide_metabolis1.74697405
40MP0003183_abnormal_peptide_metabolism1.69481726
41MP0002132_abnormal_respiratory_system1.68906683
42MP0008789_abnormal_olfactory_epithelium1.67728537
43MP0003705_abnormal_hypodermis_morpholog1.67106912
44MP0003787_abnormal_imprinting1.64538834
45MP0004043_abnormal_pH_regulation1.62202393
46MP0000049_abnormal_middle_ear1.60055798
47MP0005451_abnormal_body_composition1.60032306
48MP0002166_altered_tumor_susceptibility1.57339327
49MP0003303_peritoneal_inflammation1.57041415
50MP0005501_abnormal_skin_physiology1.55216009
51MP0005266_abnormal_metabolism1.53298468
52MP0002127_abnormal_cardiovascular_syste1.52516260
53MP0002098_abnormal_vibrissa_morphology1.49708207
54MP0003938_abnormal_ear_development1.49015456
55MP0003763_abnormal_thymus_physiology1.45629101
56MP0001800_abnormal_humoral_immune1.43241835
57MP0002233_abnormal_nose_morphology1.41878526
58MP0001672_abnormal_embryogenesis/_devel1.40965485
59MP0005380_embryogenesis_phenotype1.40965485
60MP0003690_abnormal_glial_cell1.40851698
61MP0002088_abnormal_embryonic_growth/wei1.36974805
62MP0010771_integument_phenotype1.36741588
63MP0002932_abnormal_joint_morphology1.35720667
64MP0003984_embryonic_growth_retardation1.34652808
65MP0002419_abnormal_innate_immunity1.32359044
66MP0004381_abnormal_hair_follicle1.32228700
67MP0003300_gastrointestinal_ulcer1.29746020
68MP0003755_abnormal_palate_morphology1.28626297
69MP0003656_abnormal_erythrocyte_physiolo1.27429987
70MP0002006_tumorigenesis1.26547455
71MP0003186_abnormal_redox_activity1.26478855
72MP0000427_abnormal_hair_cycle1.23942163
73MP0001851_eye_inflammation1.23352430
74MP0005508_abnormal_skeleton_morphology1.16400079
75MP0002009_preneoplasia1.16221599
76MP0000749_muscle_degeneration1.16050041
77MP0009785_altered_susceptibility_to1.15628926
78MP0005025_abnormal_response_to1.15042155
79MP0002452_abnormal_antigen_presenting1.14852268
80MP0003172_abnormal_lysosome_physiology1.12541430
81MP0002723_abnormal_immune_serum1.12202725
82MP0005464_abnormal_platelet_physiology1.12189809
83MP0000685_abnormal_immune_system1.11815272
84MP0000467_abnormal_esophagus_morphology1.10618544
85MP0005000_abnormal_immune_tolerance1.08108126
86MP0002396_abnormal_hematopoietic_system1.06961176
87MP0002653_abnormal_ependyma_morphology1.05824395
88MP0002114_abnormal_axial_skeleton1.05725542
89MP0004808_abnormal_hematopoietic_stem1.05066742
90MP0002420_abnormal_adaptive_immunity1.03214020
91MP0000432_abnormal_head_morphology1.02484521
92MP0002095_abnormal_skin_pigmentation1.02073745
93MP0002405_respiratory_system_inflammati1.01740918
94MP0001819_abnormal_immune_cell1.00833203
95MP0008961_abnormal_basal_metabolism1.00645169
96MP0001191_abnormal_skin_condition1.00392345
97MP0001849_ear_inflammation0.99946119
98MP0001293_anophthalmia0.99332516
99MP0000858_altered_metastatic_potential0.99038212
100MP0000465_gastrointestinal_hemorrhage0.98184717
101MP0000371_diluted_coat_color0.96778533
102MP0003937_abnormal_limbs/digits/tail_de0.96700889
103MP0001348_abnormal_lacrimal_gland0.95945963
104MP0008875_abnormal_xenobiotic_pharmacok0.94462653
105MP0002092_abnormal_eye_morphology0.93214707
106MP0003950_abnormal_plasma_membrane0.92921795
107MP0002086_abnormal_extraembryonic_tissu0.92067281
108MP0004782_abnormal_surfactant_physiolog0.91831793
109MP0001545_abnormal_hematopoietic_system0.91419266
110MP0005397_hematopoietic_system_phenotyp0.91419266
111MP0002398_abnormal_bone_marrow0.91004429
112MP0010030_abnormal_orbit_morphology0.90906320
113MP0000350_abnormal_cell_proliferation0.89599735
114MP0003935_abnormal_craniofacial_develop0.89083220
115MP0006054_spinal_hemorrhage0.88530286
116MP0004484_altered_response_of0.86508045
117MP0002877_abnormal_melanocyte_morpholog0.86191545
118MP0000716_abnormal_immune_system0.86039770
119MP0005023_abnormal_wound_healing0.85326269
120MP0005164_abnormal_response_to0.84011846
121MP0005076_abnormal_cell_differentiation0.83937315
122MP0004130_abnormal_muscle_cell0.83682278
123MP0000920_abnormal_myelination0.83386592
124MP0000367_abnormal_coat/_hair0.82974039
125MP0005310_abnormal_salivary_gland0.82577036
126MP0003828_pulmonary_edema0.82198251
127MP0002722_abnormal_immune_system0.81484778
128MP0003448_altered_tumor_morphology0.81279426
129MP0009931_abnormal_skin_appearance0.79122795
130MP0000647_abnormal_sebaceous_gland0.78898670
131MP0010307_abnormal_tumor_latency0.78422800
132MP0001845_abnormal_inflammatory_respons0.76624573
133MP0004883_abnormal_blood_vessel0.76426497
134MP0002751_abnormal_autonomic_nervous0.76084194
135MP0002116_abnormal_craniofacial_bone0.76073421
136MP0003329_amyloid_beta_deposits0.76042869
137MP0000604_amyloidosis0.75756501
138MP0005376_homeostasis/metabolism_phenot0.74790192
139MP0003632_abnormal_nervous_system0.74335721
140MP0003646_muscle_fatigue0.74106391
141MP0003123_paternal_imprinting0.73608693
142MP0002085_abnormal_embryonic_tissue0.73264916
143MP0005621_abnormal_cell_physiology0.72908238
144MP0009764_decreased_sensitivity_to0.71598334
145MP0003077_abnormal_cell_cycle0.71531569
146MP0000428_abnormal_craniofacial_morphol0.71092898
147MP0002925_abnormal_cardiovascular_devel0.70434789
148MP0000689_abnormal_spleen_morphology0.70156223
149MP0005248_abnormal_Harderian_gland0.69963626
150MP0000377_abnormal_hair_follicle0.68298819
151MP0001915_intracranial_hemorrhage0.67821667
152MP0003936_abnormal_reproductive_system0.67453279
153MP0003436_decreased_susceptibility_to0.66439774
154MP0008872_abnormal_physiological_respon0.66062162
155MP0004272_abnormal_basement_membrane0.65903522
156MP0004134_abnormal_chest_morphology0.64375037
157MP0003566_abnormal_cell_adhesion0.63687736
158MP0005319_abnormal_enzyme/_coenzyme0.63411100
159MP0001286_abnormal_eye_development0.63274336
160MP0004197_abnormal_fetal_growth/weight/0.62130363
161MP0003091_abnormal_cell_migration0.61321965
162MP0003453_abnormal_keratinocyte_physiol0.61279552
163MP0001790_abnormal_immune_system0.60076913
164MP0005387_immune_system_phenotype0.60076913
165MP0001905_abnormal_dopamine_level0.59697969
166MP0008770_decreased_survivor_rate0.58279519
167MP0000383_abnormal_hair_follicle0.56470618
168MP0010678_abnormal_skin_adnexa0.56416357
169MP0008775_abnormal_heart_ventricle0.56241200
170MP0000343_altered_response_to0.55446436
171MP0006036_abnormal_mitochondrial_physio0.55031109
172MP0005390_skeleton_phenotype0.53721726
173MP0009703_decreased_birth_body0.53451670

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)6.98611380
2Bilateral microphthalmos (HP:0007633)6.88713075
3Milia (HP:0001056)6.71666270
4Abnormality of nail color (HP:0100643)6.44338656
5Plantar hyperkeratosis (HP:0007556)5.80162654
6Fragile nails (HP:0001808)5.76066014
7Thick nail (HP:0001805)5.10364350
8Hepatoblastoma (HP:0002884)4.95747283
9Hypochromic microcytic anemia (HP:0004840)4.75479915
10Rib fusion (HP:0000902)4.56361346
11Atrophic scars (HP:0001075)4.37827530
12Palmoplantar hyperkeratosis (HP:0000972)4.31012907
13Recurrent bacterial skin infections (HP:0005406)4.19739220
14Multiple enchondromatosis (HP:0005701)4.18587105
15Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.17364975
16Palmar hyperkeratosis (HP:0010765)4.11309842
17Rectal fistula (HP:0100590)3.93158146
18Rectovaginal fistula (HP:0000143)3.93158146
19T lymphocytopenia (HP:0005403)3.66203672
20Partial duplication of thumb phalanx (HP:0009944)3.64659027
21Eczematoid dermatitis (HP:0000976)3.60790293
22Abnormality of the lower motor neuron (HP:0002366)3.56440860
23Intestinal fistula (HP:0100819)3.49766289
24Fused cervical vertebrae (HP:0002949)3.49592768
25Pustule (HP:0200039)3.46005418
26Increased IgE level (HP:0003212)3.44911262
27Subacute progressive viral hepatitis (HP:0006572)3.43979382
28Abnormality of T cell number (HP:0011839)3.43736361
29Aplasia/Hypoplasia of the fovea (HP:0008060)3.43468909
30Hypoplasia of the fovea (HP:0007750)3.43468909
31Vaginal fistula (HP:0004320)3.41116206
32Periodontitis (HP:0000704)3.40834387
33Chromosomal breakage induced by crosslinking agents (HP:0003221)3.35670112
34Anomalous pulmonary venous return (HP:0010772)3.35023478
35Rhabdomyosarcoma (HP:0002859)3.33622582
36Abnormality of the pubic bones (HP:0003172)3.30920105
37Recurrent abscess formation (HP:0002722)3.28842602
38Bifid tongue (HP:0010297)3.27902620
39Gingivitis (HP:0000230)3.25516408
40Preauricular pit (HP:0004467)3.23318005
41Periauricular skin pits (HP:0100277)3.23318005
42Partial duplication of the phalanx of hand (HP:0009999)3.16627759
43Neoplasm of striated muscle (HP:0009728)3.15712025
44Gingival bleeding (HP:0000225)3.13579942
45Hyperventilation (HP:0002883)3.07635943
46Abnormal cartilage morphology (HP:0002763)3.04953607
47Papillary thyroid carcinoma (HP:0002895)3.04752410
48Hyperinsulinemic hypoglycemia (HP:0000825)3.02583241
49Erythema (HP:0010783)3.00386458
50Abnormality of the pulmonary veins (HP:0011718)2.91884779
51Large earlobe (HP:0009748)2.91167908
52Nail dystrophy (HP:0008404)2.85006247
53Parakeratosis (HP:0001036)2.83736710
54Abnormal blistering of the skin (HP:0008066)2.83223550
55Ependymoma (HP:0002888)2.82380654
56Aplasia/hypoplasia of the humerus (HP:0006507)2.80754640
57Short 5th finger (HP:0009237)2.78158389
58Amyotrophic lateral sclerosis (HP:0007354)2.78071678
59Retrobulbar optic neuritis (HP:0100654)2.75519666
60Optic neuritis (HP:0100653)2.75519666
61Nephroblastoma (Wilms tumor) (HP:0002667)2.74860192
62Aplasia/Hypoplasia of the scapulae (HP:0006713)2.74537640
63Hypoplastic scapulae (HP:0000882)2.74537640
64Tetraplegia (HP:0002445)2.71799920
65Tongue fasciculations (HP:0001308)2.68197740
66Short humerus (HP:0005792)2.67781175
67Increased serum pyruvate (HP:0003542)2.64674732
68Abnormality of glycolysis (HP:0004366)2.64674732
69Recurrent skin infections (HP:0001581)2.64562101
70Ankyloglossia (HP:0010296)2.63473110
71Abnormality of the axillary hair (HP:0100134)2.62424399
72Abnormality of secondary sexual hair (HP:0009888)2.62424399
73Chromsome breakage (HP:0040012)2.60695772
74Ectropion (HP:0000656)2.58551670
75Abnormality of the salivary glands (HP:0010286)2.52885192
76Orchitis (HP:0100796)2.52728061
77Embryonal renal neoplasm (HP:0011794)2.49627107
78Abnormality of the fovea (HP:0000493)2.47749027
79Abnormality of glycolipid metabolism (HP:0010969)2.47254907
80Abnormality of liposaccharide metabolism (HP:0010968)2.47254907
81Abnormality of glycosphingolipid metabolism (HP:0004343)2.47254907
82Irregular epiphyses (HP:0010582)2.47002504
83Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.46333452
84Abnormal lung lobation (HP:0002101)2.46068536
85Sensory axonal neuropathy (HP:0003390)2.43859698
86Postural instability (HP:0002172)2.41711011
87Hypoplasia of dental enamel (HP:0006297)2.41319704
88Keratoconjunctivitis sicca (HP:0001097)2.40454077
89Muscle fibrillation (HP:0010546)2.40147363
90Cheilitis (HP:0100825)2.40043850
91Gangrene (HP:0100758)2.39956545
92Ragged-red muscle fibers (HP:0003200)2.39741146
93Urticaria (HP:0001025)2.38295879
94Recurrent fungal infections (HP:0002841)2.35358052
95Skin pits (HP:0100276)2.33991868
96Resting tremor (HP:0002322)2.33921864
97Abnormality of the corticospinal tract (HP:0002492)2.32002299
98Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.29177690
99Ridged nail (HP:0001807)2.28522406
100Abnormality of the phalanges of the hallux (HP:0010057)2.28043174
101Aplasia/Hypoplasia of the macula (HP:0008059)2.26873180
102Hypoplastic labia majora (HP:0000059)2.25604640
103Viral hepatitis (HP:0006562)2.25508227
104Abnormality of the intrinsic pathway (HP:0010989)2.25078605
105Generalized hypotonia (HP:0001290)2.24504949
106Lip pit (HP:0100267)2.22644777
107Spastic tetraparesis (HP:0001285)2.22244469
108Myositis (HP:0100614)2.21838921
109Skin ulcer (HP:0200042)2.20510027
110Abnormality of the distal phalanx of the thumb (HP:0009617)2.19316419
111Keratoconjunctivitis (HP:0001096)2.18110344
112Acute myeloid leukemia (HP:0004808)2.18101760
113Reduced antithrombin III activity (HP:0001976)2.17466240
114Gastrointestinal infarctions (HP:0005244)2.17016692
115Alopecia of scalp (HP:0002293)2.16396698
116Abnormality of the labia majora (HP:0012881)2.13957623
117Spontaneous hematomas (HP:0007420)2.13253920
118Flat capital femoral epiphysis (HP:0003370)2.12561413
119Abnormality of the distal phalanges of the toes (HP:0010182)2.12425981
120Aplasia/Hypoplasia affecting the retina (HP:0008061)2.11100744
121Recurrent gram-negative bacterial infections (HP:0005420)2.09819819
122Recurrent viral infections (HP:0004429)2.09550124
123Abnormality of the astrocytes (HP:0100707)2.09297844
124Astrocytoma (HP:0009592)2.09297844
125Wide anterior fontanel (HP:0000260)2.08324075
126Fair hair (HP:0002286)2.07876893
127Short middle phalanx of the 5th finger (HP:0004220)2.07730982
128Hyperhidrosis (HP:0000975)2.06161003
129Congenital ichthyosiform erythroderma (HP:0007431)2.04895793
130Ulnar bowing (HP:0003031)2.03323485
131Upper motor neuron abnormality (HP:0002127)2.02549125
132Meckel diverticulum (HP:0002245)2.01177036
133Inflammation of the large intestine (HP:0002037)2.00466701
134Conjunctival telangiectasia (HP:0000524)2.00183973
135Hypoplastic ischia (HP:0003175)1.99995782
136Impulsivity (HP:0100710)1.99593581
137Chronic mucocutaneous candidiasis (HP:0002728)1.99468553
138Recurrent cutaneous fungal infections (HP:0011370)1.99468553
139Sparse scalp hair (HP:0002209)1.99191747
140Vitreoretinal degeneration (HP:0000655)1.98754620
141Peritonitis (HP:0002586)1.98279682
142Curly hair (HP:0002212)1.96898272
143Nasolacrimal duct obstruction (HP:0000579)1.95364839
144Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95267773
145Progressive muscle weakness (HP:0003323)1.95010186
146Anhidrosis (HP:0000970)1.94672081
147Glossoptosis (HP:0000162)1.93335635
148Aplasia/Hypoplasia of the uvula (HP:0010293)1.93106162
149Abnormality of oral frenula (HP:0000190)1.92394859
150Prominent occiput (HP:0000269)1.92321706
151Pruritus (HP:0000989)1.91906353
1523-Methylglutaconic aciduria (HP:0003535)1.91865059
153Neoplasm of the tracheobronchial system (HP:0100552)1.91040318
154Trismus (HP:0000211)1.90206114
155Abnormality of the intervertebral disk (HP:0005108)1.88511337
156Testicular atrophy (HP:0000029)1.88332595
157Hypokinesia (HP:0002375)1.87814267
158Combined immunodeficiency (HP:0005387)1.86322994
159Abnormality of the ileum (HP:0001549)1.86039951
160Right ventricular cardiomyopathy (HP:0011663)1.86039802
161Hypopigmentation of the fundus (HP:0007894)1.85877893
162Duplication of thumb phalanx (HP:0009942)1.85842795
163Ventricular tachycardia (HP:0004756)1.85837470
164Erythroderma (HP:0001019)1.85619625
165Laryngomalacia (HP:0001601)1.84770489
166Autoimmune hemolytic anemia (HP:0001890)1.84085084
167Delayed epiphyseal ossification (HP:0002663)1.83687791
168Spinal muscular atrophy (HP:0007269)1.83496841
169Difficulty walking (HP:0002355)1.83133941
170Small hand (HP:0200055)1.82982408
171Abnormality of T cells (HP:0002843)1.82915040
172Generalized hypopigmentation of hair (HP:0011358)1.82582742
173Absent frontal sinuses (HP:0002688)1.82343918
174Difficulty running (HP:0009046)1.82045708
175Slow saccadic eye movements (HP:0000514)1.81406608
176Arterial thrombosis (HP:0004420)1.80536326
177Aplasia/Hypoplasia of the sternum (HP:0006714)1.80355052
178Hand muscle atrophy (HP:0009130)1.80091731
179Oral leukoplakia (HP:0002745)1.79911270
180Acanthocytosis (HP:0001927)1.78370504
181Thyroid carcinoma (HP:0002890)1.78336483
182Widely spaced teeth (HP:0000687)1.78243311
183Submucous cleft hard palate (HP:0000176)1.78025983
184Leukocytosis (HP:0001974)1.77156499
185Thyroiditis (HP:0100646)1.76908110
186Dehydration (HP:0001944)1.74677549
187Poikilocytosis (HP:0004447)1.74630195
188Gastrointestinal inflammation (HP:0004386)1.74421931
189Abnormal delayed hypersensitivity skin test (HP:0002963)1.74028842
190Mediastinal lymphadenopathy (HP:0100721)1.73894191
191Xerostomia (HP:0000217)1.73488438
192Aplasia cutis congenita (HP:0001057)1.72138733
193Amelogenesis imperfecta (HP:0000705)1.71980937
194Abnormality of macrophages (HP:0004311)1.71955578
195Palmoplantar keratoderma (HP:0000982)1.69646245
196Poikiloderma (HP:0001029)1.69265759
197Stomach cancer (HP:0012126)1.68866037

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.66298483
2GRK55.74300509
3GRK64.90913649
4ERN14.00830617
5GRK13.97613687
6ADRBK23.93034002
7CSF1R2.85674376
8RIPK42.53024215
9IRAK42.48209714
10WNK12.46001826
11MAP3K22.41542997
12BLK2.36022998
13IKBKE2.33439226
14STK102.21778696
15SGK22.20047005
16TYRO32.07895734
17MAPK72.07009218
18TTK2.06420178
19IRAK12.05915855
20GRK72.05800027
21ACVR1B1.89456145
22TGFBR21.88602630
23SGK31.80255794
24MST41.77820943
25PIK3CG1.74554209
26FGR1.72240760
27IRAK21.70477688
28YES11.69071940
29TAOK31.58715600
30EPHA21.55049850
31JAK31.52890197
32BTK1.52120568
33STK241.46619665
34CAMK1D1.45643017
35MAP3K61.41435606
36MOS1.40129195
37CAMK41.39775484
38PDGFRB1.39703068
39MAP2K31.39113265
40PRKG21.36175447
41BRD41.35043280
42SGK4941.32761899
43SGK2231.32761899
44MATK1.32015502
45JAK11.29740785
46MAP3K11.28995899
47PLK21.26437108
48ADRBK11.25390947
49FGFR31.21113497
50SYK1.20777056
51BRSK21.18847531
52PIM11.16977078
53CDK61.16102068
54OBSCN1.15949652
55CAMK1G1.11254120
56MAP3K101.10047151
57HCK1.09483729
58ALK1.09250615
59JAK21.08545585
60PTK2B1.07794192
61TYK21.06363808
62MST1R1.05703319
63MARK21.04883198
64CDK71.03717402
65RAF11.03323153
66TRPM71.01210233
67TXK0.99653369
68TEC0.98840497
69FES0.97453153
70DYRK30.96643022
71CAMKK20.95426099
72EPHB10.95289468
73KSR20.93772879
74STK390.93217597
75IKBKB0.92593081
76KSR10.91230480
77LATS10.90120799
78EIF2AK20.89400031
79PAK40.85250836
80PBK0.83688139
81MAP2K40.81977708
82AKT30.81620138
83HIPK20.80435964
84NTRK10.79967443
85SGK10.78190286
86MAP3K70.77888660
87MELK0.76511197
88MAP3K50.75854579
89MARK30.74955912
90MAP3K140.73814614
91BMPR20.73553505
92BCR0.72997903
93LCK0.71516268
94CHEK20.71364035
95ZAP700.70883691
96NLK0.70657581
97PLK10.70126018
98LYN0.67741912
99GSK3A0.66631874
100STK40.66233070
101AKT20.64987090
102MAP3K40.64081504
103DYRK20.63880358
104ZAK0.63732415
105CSK0.59729113
106MAPK120.59514833
107EPHA30.58883088
108STK110.57979322
109PRKCD0.55622884
110MAP3K30.54228990
111IRAK30.53199763
112IGF1R0.53008134
113CHEK10.52330207
114BMPR1B0.52313666
115PRKD30.51615554
116PRKAA20.51089968
117CHUK0.50366244
118PTK60.47820533
119NUAK10.47189852
120PDK20.43972346
121STK38L0.43460286
122SRPK10.43147545
123NME10.42510184
124PIK3CA0.40885995
125FER0.40297180
126TAOK10.38238630
127RPS6KB10.36312589
128RET0.36009297
129MAPKAPK30.35674880
130PAK30.35251375
131PRKCQ0.34985671
132FYN0.34359648
133ERBB20.31133491
134PRKCI0.30509893
135ICK0.29980534
136TESK20.27892938
137ATM0.26852838
138PINK10.26267904
139RPS6KB20.26138457
140OXSR10.26014756
141MAPKAPK20.25995348
142MAP3K130.25452669
143MTOR0.24167911
144PRKCH0.23852708
145STK30.23716360
146BMX0.22192621
147ITK0.21033448
148PRKACB0.20783276
149DDR20.19432387
150DYRK1A0.19288012
151NEK60.18236151
152FRK0.17726287
153MAPK40.17679226
154EGFR0.17427019
155AURKB0.16795403
156PRKACA0.16729532
157MAPK10.16016799
158CDK20.15954494
159MAP2K60.15630920
160CDK40.15060475
161INSR0.14535509
162ERBB30.13830873
163PRKACG0.13760440
164CSNK1E0.12772100
165MET0.12274941
166PKN10.12154982
167CDK10.11891535

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.75498542
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.84726329
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.71349885
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10178072
5Fructose and mannose metabolism_Homo sapiens_hsa000512.95705028
6Arachidonic acid metabolism_Homo sapiens_hsa005902.80144726
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.71359769
8Galactose metabolism_Homo sapiens_hsa000522.56697845
9Linoleic acid metabolism_Homo sapiens_hsa005912.35914084
10Chemical carcinogenesis_Homo sapiens_hsa052042.35196670
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.25797052
12Ether lipid metabolism_Homo sapiens_hsa005652.06910760
13B cell receptor signaling pathway_Homo sapiens_hsa046622.04725069
14Steroid biosynthesis_Homo sapiens_hsa001002.02793391
15Osteoclast differentiation_Homo sapiens_hsa043801.94430580
16Non-small cell lung cancer_Homo sapiens_hsa052231.88644324
17Dorso-ventral axis formation_Homo sapiens_hsa043201.83804287
18Toxoplasmosis_Homo sapiens_hsa051451.78711648
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.72220509
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69511417
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67379988
22Small cell lung cancer_Homo sapiens_hsa052221.63768915
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63161012
24Measles_Homo sapiens_hsa051621.62390635
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60594727
26One carbon pool by folate_Homo sapiens_hsa006701.56143208
27Pancreatic cancer_Homo sapiens_hsa052121.53510539
28FoxO signaling pathway_Homo sapiens_hsa040681.52710626
29Fatty acid elongation_Homo sapiens_hsa000621.51931195
30Tuberculosis_Homo sapiens_hsa051521.50915815
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50717580
32African trypanosomiasis_Homo sapiens_hsa051431.49043641
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42272758
34Chronic myeloid leukemia_Homo sapiens_hsa052201.42199811
35Graft-versus-host disease_Homo sapiens_hsa053321.41617253
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38704593
37T cell receptor signaling pathway_Homo sapiens_hsa046601.36348025
38Acute myeloid leukemia_Homo sapiens_hsa052211.34182223
39Influenza A_Homo sapiens_hsa051641.31219551
40* Jak-STAT signaling pathway_Homo sapiens_hsa046301.31049000
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.30724056
42Inositol phosphate metabolism_Homo sapiens_hsa005621.30576076
43ErbB signaling pathway_Homo sapiens_hsa040121.29454461
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29317052
45Amoebiasis_Homo sapiens_hsa051461.28826809
46Platelet activation_Homo sapiens_hsa046111.25957522
47TNF signaling pathway_Homo sapiens_hsa046681.25495068
48Renal cell carcinoma_Homo sapiens_hsa052111.24548320
49Prolactin signaling pathway_Homo sapiens_hsa049171.22968947
50Hepatitis B_Homo sapiens_hsa051611.21850479
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20222003
52Staphylococcus aureus infection_Homo sapiens_hsa051501.19530444
53Endometrial cancer_Homo sapiens_hsa052131.19089534
54Hematopoietic cell lineage_Homo sapiens_hsa046401.16915312
55Folate biosynthesis_Homo sapiens_hsa007901.13640100
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13469645
57Glioma_Homo sapiens_hsa052141.13194364
58Hepatitis C_Homo sapiens_hsa051601.11437509
59Ovarian steroidogenesis_Homo sapiens_hsa049131.10824780
60VEGF signaling pathway_Homo sapiens_hsa043701.10305821
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10104094
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08670430
63Neurotrophin signaling pathway_Homo sapiens_hsa047221.08009761
64Chemokine signaling pathway_Homo sapiens_hsa040621.06108749
65NF-kappa B signaling pathway_Homo sapiens_hsa040641.05299955
66Pentose phosphate pathway_Homo sapiens_hsa000301.04182925
67Complement and coagulation cascades_Homo sapiens_hsa046101.02586740
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99634901
69RNA transport_Homo sapiens_hsa030130.99347000
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96547106
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95937751
72Regulation of autophagy_Homo sapiens_hsa041400.92385176
73Prostate cancer_Homo sapiens_hsa052150.90879692
74GnRH signaling pathway_Homo sapiens_hsa049120.88902743
75Viral carcinogenesis_Homo sapiens_hsa052030.87853762
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87336166
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86230105
78mTOR signaling pathway_Homo sapiens_hsa041500.84543018
79ECM-receptor interaction_Homo sapiens_hsa045120.84346669
80Malaria_Homo sapiens_hsa051440.84111069
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82859563
82Focal adhesion_Homo sapiens_hsa045100.80829907
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79557478
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79465329
85Colorectal cancer_Homo sapiens_hsa052100.77779008
86Proteoglycans in cancer_Homo sapiens_hsa052050.77462237
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76651534
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76552020
89Tryptophan metabolism_Homo sapiens_hsa003800.76379864
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.76238174
91Choline metabolism in cancer_Homo sapiens_hsa052310.73826909
92* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73433505
93RNA polymerase_Homo sapiens_hsa030200.72593760
94Glutathione metabolism_Homo sapiens_hsa004800.72424864
95Long-term depression_Homo sapiens_hsa047300.70762657
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70174988
97mRNA surveillance pathway_Homo sapiens_hsa030150.70140388
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.69543584
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69231243
100Systemic lupus erythematosus_Homo sapiens_hsa053220.68905829
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.68452607
102Fatty acid biosynthesis_Homo sapiens_hsa000610.67234666
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67118785
104Salmonella infection_Homo sapiens_hsa051320.66392511
105Circadian rhythm_Homo sapiens_hsa047100.66283086
106HIF-1 signaling pathway_Homo sapiens_hsa040660.66077775
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64796773
108Phagosome_Homo sapiens_hsa041450.64624632
109MAPK signaling pathway_Homo sapiens_hsa040100.63781536
110Carbon metabolism_Homo sapiens_hsa012000.63444401
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63240480
112Long-term potentiation_Homo sapiens_hsa047200.60793624
113Legionellosis_Homo sapiens_hsa051340.60789380
114Nitrogen metabolism_Homo sapiens_hsa009100.60667265
115Sphingolipid metabolism_Homo sapiens_hsa006000.60061526
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58314455
117Notch signaling pathway_Homo sapiens_hsa043300.57418000
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57376009
119Thyroid cancer_Homo sapiens_hsa052160.56655806
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.56289759
121Shigellosis_Homo sapiens_hsa051310.54289084
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53989838
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53641131
124Leishmaniasis_Homo sapiens_hsa051400.53069327
125Endocytosis_Homo sapiens_hsa041440.52953276
126Insulin resistance_Homo sapiens_hsa049310.52745696
127Retinol metabolism_Homo sapiens_hsa008300.52318362
128Estrogen signaling pathway_Homo sapiens_hsa049150.51185125
129Type II diabetes mellitus_Homo sapiens_hsa049300.51085752
130RNA degradation_Homo sapiens_hsa030180.50870697
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50629061
132* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49844298
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48560605
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47349284
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45956181
136Pathways in cancer_Homo sapiens_hsa052000.45317403
137Sulfur metabolism_Homo sapiens_hsa009200.44196318
138Taste transduction_Homo sapiens_hsa047420.42940883
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42684447
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.41301882
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38907617
142MicroRNAs in cancer_Homo sapiens_hsa052060.38323389
143Vitamin digestion and absorption_Homo sapiens_hsa049770.37522287
144Cell cycle_Homo sapiens_hsa041100.36006628
145Sulfur relay system_Homo sapiens_hsa041220.35814632
146Metabolic pathways_Homo sapiens_hsa011000.34481775
147Starch and sucrose metabolism_Homo sapiens_hsa005000.34208495
148Herpes simplex infection_Homo sapiens_hsa051680.34006505
149Other glycan degradation_Homo sapiens_hsa005110.33596709
150Caffeine metabolism_Homo sapiens_hsa002320.31732275
151p53 signaling pathway_Homo sapiens_hsa041150.31616133
152Cardiac muscle contraction_Homo sapiens_hsa042600.30760758
153Tight junction_Homo sapiens_hsa045300.30210101
154Histidine metabolism_Homo sapiens_hsa003400.30121280
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.29783636
156Phospholipase D signaling pathway_Homo sapiens_hsa040720.29707754
157Rheumatoid arthritis_Homo sapiens_hsa053230.29100662
158Apoptosis_Homo sapiens_hsa042100.28808769
159Hippo signaling pathway_Homo sapiens_hsa043900.28416171
160Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28385594
161Peroxisome_Homo sapiens_hsa041460.26413668
162Biosynthesis of amino acids_Homo sapiens_hsa012300.25860877
163Prion diseases_Homo sapiens_hsa050200.25649165
164Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25623796
165PPAR signaling pathway_Homo sapiens_hsa033200.23506571
166Serotonergic synapse_Homo sapiens_hsa047260.22950501
167Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22466839
168Adherens junction_Homo sapiens_hsa045200.21523235
169Pertussis_Homo sapiens_hsa051330.19781878
170Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19430039
171Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18849826
172Cysteine and methionine metabolism_Homo sapiens_hsa002700.18702650
173Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.18623579
174Arginine and proline metabolism_Homo sapiens_hsa003300.18277858

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »