IFNL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)9.80829530
2regulation of establishment of cell polarity (GO:2000114)9.16810685
3sex differentiation (GO:0007548)8.13143678
4sterol catabolic process (GO:0016127)7.41252780
5cholesterol catabolic process (GO:0006707)7.41252780
6regulation of establishment or maintenance of cell polarity (GO:0032878)7.35977817
7stress granule assembly (GO:0034063)7.19319574
8positive regulation of vasculogenesis (GO:2001214)7.02259087
9type I interferon signaling pathway (GO:0060337)6.70801888
10cellular response to type I interferon (GO:0071357)6.70801888
11alternative mRNA splicing, via spliceosome (GO:0000380)6.63412449
12response to type I interferon (GO:0034340)6.63332499
13kynurenine metabolic process (GO:0070189)6.45827762
14cerebellar Purkinje cell differentiation (GO:0021702)6.18538603
15negative regulation of receptor-mediated endocytosis (GO:0048261)6.17288274
16indole-containing compound catabolic process (GO:0042436)5.89618139
17indolalkylamine catabolic process (GO:0046218)5.89618139
18tryptophan catabolic process (GO:0006569)5.89618139
19ADP metabolic process (GO:0046031)5.85710885
20regulation of metalloenzyme activity (GO:0048552)5.82417447
21nucleoside diphosphate catabolic process (GO:0009134)5.54433728
22regulation of vasculogenesis (GO:2001212)5.33759339
23negative regulation of viral genome replication (GO:0045071)5.33161238
24negative regulation of endothelial cell apoptotic process (GO:2000352)5.14406743
25tryptophan metabolic process (GO:0006568)5.07453607
26positive regulation of heat generation (GO:0031652)5.01514374
27cellular response to exogenous dsRNA (GO:0071360)4.85408405
28bile acid biosynthetic process (GO:0006699)4.80147790
29response to interferon-beta (GO:0035456)4.77789238
30centrosome duplication (GO:0051298)4.71759781
31lipid particle organization (GO:0034389)4.28113861
32regulation of triglyceride catabolic process (GO:0010896)4.18230096
33* regulation of MHC class I biosynthetic process (GO:0045343)4.03519453
34iron-sulfur cluster assembly (GO:0016226)4.00444346
35metallo-sulfur cluster assembly (GO:0031163)4.00444346
36positive regulation of tolerance induction (GO:0002645)3.97016321
37regulation of T cell tolerance induction (GO:0002664)3.96436749
38regulation of regulatory T cell differentiation (GO:0045589)3.90497623
39regulation of heat generation (GO:0031650)3.77519059
40negative regulation of endothelial cell proliferation (GO:0001937)3.77405569
41amine catabolic process (GO:0009310)3.72158916
42cellular biogenic amine catabolic process (GO:0042402)3.72158916
43regulation of superoxide metabolic process (GO:0090322)3.68749009
44regulation of G0 to G1 transition (GO:0070316)3.67875371
45steroid catabolic process (GO:0006706)3.66469975
46cellular response to interferon-alpha (GO:0035457)3.66389931
47positive regulation of fatty acid beta-oxidation (GO:0032000)3.65857769
48regulation of membrane protein ectodomain proteolysis (GO:0051043)3.63202452
49purine ribonucleoside diphosphate metabolic process (GO:0009179)3.62565209
50purine nucleoside diphosphate metabolic process (GO:0009135)3.62565209
51positive regulation of defense response to virus by host (GO:0002230)3.60981910
52NAD biosynthetic process (GO:0009435)3.54262703
53protein autoprocessing (GO:0016540)3.54129958
54indolalkylamine metabolic process (GO:0006586)3.49257268
55regulation of viral genome replication (GO:0045069)3.42817278
56positive regulation of triglyceride biosynthetic process (GO:0010867)3.40429681
57aromatic amino acid family catabolic process (GO:0009074)3.40035364
58regulation of action potential (GO:0098900)3.35311873
59negative regulation of mast cell activation (GO:0033004)3.34009805
60phospholipid translocation (GO:0045332)3.31970943
61lipid translocation (GO:0034204)3.31970943
62regulation of tolerance induction (GO:0002643)3.31475235
63positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.30491911
64regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.30491911
65negative regulation of viral process (GO:0048525)3.30345446
66histone H3-K4 trimethylation (GO:0080182)3.29718113
67* defense response to virus (GO:0051607)3.27261675
68synaptic transmission, cholinergic (GO:0007271)3.24676715
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.21860539
70phosphatidylglycerol biosynthetic process (GO:0006655)3.19746696
71negative regulation of endothelial cell migration (GO:0010596)3.19672900
72regulation of sequestering of triglyceride (GO:0010889)3.17261096
73regulation of endothelial cell apoptotic process (GO:2000351)3.16088014
74regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.14055575
75regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.13640990
76positive regulation of natural killer cell activation (GO:0032816)3.02435855
77interferon-gamma-mediated signaling pathway (GO:0060333)3.00456200
78estrogen biosynthetic process (GO:0006703)2.97183420
79response to X-ray (GO:0010165)2.96451637
80response to cold (GO:0009409)2.91975556
81positive regulation of lipid storage (GO:0010884)2.91585051
82regulation of interferon-alpha production (GO:0032647)2.89817519
83cell differentiation in hindbrain (GO:0021533)2.88447835
84somite rostral/caudal axis specification (GO:0032525)2.87277331
85pyridine nucleotide biosynthetic process (GO:0019363)2.85763565
86nicotinamide nucleotide biosynthetic process (GO:0019359)2.85763565
87regulation of phospholipid biosynthetic process (GO:0071071)2.84898741
88regulation of defense response to virus by host (GO:0050691)2.84698952
89regulation of actin nucleation (GO:0051125)2.84634411
90natural killer cell activation involved in immune response (GO:0002323)2.84452376
91response to interferon-alpha (GO:0035455)2.81719508
92positive regulation of natural killer cell differentiation (GO:0032825)2.81032989
93acrosome assembly (GO:0001675)2.79245254
94negative regulation of macroautophagy (GO:0016242)2.73113675
95regulation of response to reactive oxygen species (GO:1901031)2.72387303
96disruption of cells of other organism (GO:0044364)2.72246548
97killing of cells of other organism (GO:0031640)2.72246548
98bile acid metabolic process (GO:0008206)2.71750127
99positive regulation of protein homooligomerization (GO:0032464)2.70315331
100negative regulation of multicellular organism growth (GO:0040015)10.8930334

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.32377421
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.96057708
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.91929339
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.89736292
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.55509424
6VDR_22108803_ChIP-Seq_LS180_Human3.53454812
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.96294024
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60446384
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.52547922
10EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.50721237
11TAF15_26573619_Chip-Seq_HEK293_Human2.45002566
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43034590
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08123353
14BCAT_22108803_ChIP-Seq_LS180_Human2.02323256
15ER_23166858_ChIP-Seq_MCF-7_Human1.96735380
16IRF8_27001747_Chip-Seq_BMDM_Mouse1.94890461
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94325658
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.71517300
19MYB_26560356_Chip-Seq_TH2_Human1.66160685
20OCT1_27270436_Chip-Seq_PROSTATE_Human1.58382977
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57743681
22TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.57107768
23TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.46178549
24DROSHA_22980978_ChIP-Seq_HELA_Human1.44552771
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43510756
26PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38527100
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.36608006
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32508711
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30875147
30CDX2_22108803_ChIP-Seq_LS180_Human1.30365437
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29945711
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.28901783
33TP53_18474530_ChIP-ChIP_U2OS_Human1.28441180
34JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28157813
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.27396545
36JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24457466
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23167578
38PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18380306
39SMAD4_21741376_ChIP-Seq_EPCs_Human1.17377107
40CJUN_26792858_Chip-Seq_BT549_Human1.17184556
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14380810
42LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11858749
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09849043
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09536488
45GATA4_25053715_ChIP-Seq_YYC3_Human1.07691594
46RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06369161
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06283326
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.06283326
49ESET_19884257_ChIP-Seq_ESCs_Mouse1.06034317
50RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06014915
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.04262843
52GATA3_21867929_ChIP-Seq_TH1_Mouse1.04142406
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.03894660
54GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.03311761
55TAF2_19829295_ChIP-Seq_ESCs_Human1.03185699
56RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02871280
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02773809
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02554044
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02500228
60IGF1R_20145208_ChIP-Seq_DFB_Human1.00854211
61KDM2B_26808549_Chip-Seq_REH_Human0.99853401
62KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99391177
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98818047
64ARNT_22903824_ChIP-Seq_MCF-7_Human0.96142243
65ERA_21632823_ChIP-Seq_H3396_Human0.95405583
66FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93995410
67OCT4_20526341_ChIP-Seq_ESCs_Human0.92612073
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92340116
69EZH2_22144423_ChIP-Seq_EOC_Human0.92161827
70SMRT_27268052_Chip-Seq_Bcells_Human0.91572620
71ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91412668
72TP63_23658742_ChIP-Seq_EP156T_Human0.90958602
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90625070
74SMAD_19615063_ChIP-ChIP_OVARY_Human0.90487343
75NCOR_22424771_ChIP-Seq_293T_Human0.89227437
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.87493937
77STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87063721
78STAT1_20625510_ChIP-Seq_HELA_Human0.86807980
79VDR_24787735_ChIP-Seq_THP-1_Human0.86289900
80HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86178292
81IRF1_19129219_ChIP-ChIP_H3396_Human0.85946818
82SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85816144
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84237727
84CEBPB_22108803_ChIP-Seq_LS180_Human0.83128053
85NMYC_18555785_Chip-Seq_ESCs_Mouse0.82720563
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.81825006
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81662048
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81043988
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80981499
90MYC_19829295_ChIP-Seq_ESCs_Human0.80170540
91AR_25329375_ChIP-Seq_VCAP_Human0.79845002
92TAL1_26923725_Chip-Seq_HPCs_Mouse0.79106581
93RXR_22108803_ChIP-Seq_LS180_Human0.78808858
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76880884
95STAT1_17558387_ChIP-Seq_HELA_Human0.76045865
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.75992530
97JARID2_20075857_ChIP-Seq_MESCs_Mouse0.75211342
98NFYA_21822215_ChIP-Seq_K562_Human0.75126711
99WDR5_24793694_ChIP-Seq_LNCAP_Human0.74997932
100POU5F1_16518401_ChIP-PET_MESCs_Mouse0.74725765

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003252_abnormal_bile_duct6.20561226
2MP0000569_abnormal_digit_pigmentation5.41812572
3MP0003011_delayed_dark_adaptation5.13565837
4MP0006082_CNS_inflammation3.67403949
5MP0002736_abnormal_nociception_after3.49910429
6MP0001986_abnormal_taste_sensitivity2.97924637
7MP0000371_diluted_coat_color2.81947224
8MP0001835_abnormal_antigen_presentation2.58526510
9MP0009785_altered_susceptibility_to2.54791670
10MP0002148_abnormal_hypersensitivity_rea2.41850386
11MP0003303_peritoneal_inflammation2.41135434
12MP0001968_abnormal_touch/_nociception2.40253238
13MP0003186_abnormal_redox_activity2.32063135
14MP0003724_increased_susceptibility_to2.18886927
15MP0005025_abnormal_response_to2.18111586
16MP0003195_calcinosis2.04203170
17MP0002138_abnormal_hepatobiliary_system1.99002259
18MP0005387_immune_system_phenotype1.92866280
19MP0001790_abnormal_immune_system1.92866280
20MP0004510_myositis1.89779200
21MP0005671_abnormal_response_to1.82320027
22MP0000685_abnormal_immune_system1.79339486
23MP0009764_decreased_sensitivity_to1.76878785
24MP0001501_abnormal_sleep_pattern1.74970316
25MP0002139_abnormal_hepatobiliary_system1.74458550
26MP0005000_abnormal_immune_tolerance1.67571877
27MP0003172_abnormal_lysosome_physiology1.67406248
28MP0005334_abnormal_fat_pad1.65445159
29MP0003646_muscle_fatigue1.62841664
30MP0001800_abnormal_humoral_immune1.61266747
31MP0005647_abnormal_sex_gland1.52163189
32MP0001348_abnormal_lacrimal_gland1.51577267
33MP0002723_abnormal_immune_serum1.48886878
34MP0004130_abnormal_muscle_cell1.47950486
35MP0005253_abnormal_eye_physiology1.43132304
36MP0009840_abnormal_foam_cell1.43111343
37MP0002419_abnormal_innate_immunity1.37302286
38MP0003436_decreased_susceptibility_to1.36489184
39MP0004947_skin_inflammation1.36215104
40MP0002452_abnormal_antigen_presenting1.35064177
41MP0009745_abnormal_behavioral_response1.33912825
42MP0005174_abnormal_tail_pigmentation1.33316483
43MP0002837_dystrophic_cardiac_calcinosis1.31616718
44MP0001666_abnormal_nutrient_absorption1.26526509
45MP0001845_abnormal_inflammatory_respons1.25638800
46MP0010155_abnormal_intestine_physiology1.23808044
47MP0005310_abnormal_salivary_gland1.23666259
48MP0002693_abnormal_pancreas_physiology1.17556177
49MP0003950_abnormal_plasma_membrane1.15248235
50MP0004381_abnormal_hair_follicle1.14647941
51MP0001819_abnormal_immune_cell1.14451244
52MP0002420_abnormal_adaptive_immunity1.12382492
53MP0009046_muscle_twitch1.12156472
54MP0002163_abnormal_gland_morphology1.08110969
55MP0000343_altered_response_to1.05820542
56MP0005083_abnormal_biliary_tract1.05665911
57MP0009763_increased_sensitivity_to1.05603560
58MP0004264_abnormal_extraembryonic_tissu1.03325928
59MP0008469_abnormal_protein_level1.02733709
60MP0005166_decreased_susceptibility_to1.00431651
61MP0005075_abnormal_melanosome_morpholog0.99937162
62MP0002075_abnormal_coat/hair_pigmentati0.99142892
63MP0004742_abnormal_vestibular_system0.97181223
64MP0005636_abnormal_mineral_homeostasis0.95123379
65MP0005410_abnormal_fertilization0.93345370
66MP0003806_abnormal_nucleotide_metabolis0.92986466
67MP0005645_abnormal_hypothalamus_physiol0.92492906
68MP0002118_abnormal_lipid_homeostasis0.90416031
69MP0001533_abnormal_skeleton_physiology0.90204940
70MP0002877_abnormal_melanocyte_morpholog0.88218155
71MP0006072_abnormal_retinal_apoptosis0.84597643
72MP0000015_abnormal_ear_pigmentation0.84210545
73MP0005085_abnormal_gallbladder_physiolo0.83768268
74MP0003075_altered_response_to0.81639659
75MP0005670_abnormal_white_adipose0.78114100
76MP0003137_abnormal_impulse_conducting0.77897796
77MP0009765_abnormal_xenobiotic_induced0.76897520
78MP0008961_abnormal_basal_metabolism0.75480236
79MP0008004_abnormal_stomach_pH0.73346698
80MP0003690_abnormal_glial_cell0.72312378
81MP0000609_abnormal_liver_physiology0.71592169
82MP0000427_abnormal_hair_cycle0.69751966
83MP0009333_abnormal_splenocyte_physiolog0.69174356
84MP0003448_altered_tumor_morphology0.68954116
85MP0003718_maternal_effect0.67099971
86MP0002405_respiratory_system_inflammati0.66307114
87MP0002064_seizures0.66230385
88MP0001873_stomach_inflammation0.65932174
89MP0000372_irregular_coat_pigmentation0.65151958
90MP0002733_abnormal_thermal_nociception0.64758781
91MP0001764_abnormal_homeostasis0.64510270
92MP0001186_pigmentation_phenotype0.64198810
93MP0005646_abnormal_pituitary_gland0.63716320
94MP0006035_abnormal_mitochondrial_morpho0.63608567
95MP0005084_abnormal_gallbladder_morpholo0.62556359
96MP0009384_cardiac_valve_regurgitation0.62065504
97MP0003763_abnormal_thymus_physiology0.60891437
98MP0000716_abnormal_immune_system0.60343120
99MP0000013_abnormal_adipose_tissue0.60316891
100MP0005464_abnormal_platelet_physiology0.59648324

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)9.62782050
2Progressive cerebellar ataxia (HP:0002073)7.71786309
3Prostate neoplasm (HP:0100787)7.56775772
4Slow saccadic eye movements (HP:0000514)6.47984108
5Absence seizures (HP:0002121)6.42325456
6Abnormality of the hepatic vasculature (HP:0006707)5.40003610
7Urinary bladder sphincter dysfunction (HP:0002839)5.16178290
8Pendular nystagmus (HP:0012043)5.15389868
9Postural instability (HP:0002172)4.98511228
10Postural tremor (HP:0002174)4.88852737
11Gaze-evoked nystagmus (HP:0000640)4.87812335
12Dialeptic seizures (HP:0011146)4.79867293
13Dysdiadochokinesis (HP:0002075)4.77380237
14Severe visual impairment (HP:0001141)4.54461726
15Limb ataxia (HP:0002070)4.26343325
16Hypochromic microcytic anemia (HP:0004840)4.17225155
17Abnormality of the prostate (HP:0008775)4.11518735
18Impaired smooth pursuit (HP:0007772)4.03644151
19Impaired vibratory sensation (HP:0002495)3.97405364
20Abnormality of macular pigmentation (HP:0008002)3.46375525
21Focal seizures (HP:0007359)3.35098730
22Impaired proprioception (HP:0010831)3.27874542
23Gingival bleeding (HP:0000225)3.15499687
24Hypochromic anemia (HP:0001931)2.71376101
25Abnormality of saccadic eye movements (HP:0000570)2.69559459
26Abnormality of ocular smooth pursuit (HP:0000617)2.68211242
27Loss of speech (HP:0002371)2.63581279
28Abnormality of male internal genitalia (HP:0000022)2.51681539
29Recurrent bacterial skin infections (HP:0005406)2.49583993
30Arterial thrombosis (HP:0004420)2.47907285
31Postnatal microcephaly (HP:0005484)2.46872042
32Areflexia of lower limbs (HP:0002522)2.42714439
33Focal motor seizures (HP:0011153)2.33142785
34Abnormality of vision evoked potentials (HP:0000649)2.32809160
35Recurrent abscess formation (HP:0002722)2.21870953
36Retrobulbar optic neuritis (HP:0100654)2.21244309
37Optic neuritis (HP:0100653)2.21244309
38Bilateral microphthalmos (HP:0007633)2.10458025
39Chorioretinal atrophy (HP:0000533)2.08643976
40Amaurosis fugax (HP:0100576)2.06514157
41Tinnitus (HP:0000360)2.06225748
42Genetic anticipation (HP:0003743)10.6587631
43Dysmetric saccades (HP:0000641)10.3643472
44Abnormality of T cell number (HP:0011839)1.98635766
45Chest pain (HP:0100749)1.98290811
46Clumsiness (HP:0002312)1.97709091
47Fair hair (HP:0002286)1.92876697
48Rib fusion (HP:0000902)1.92795938
49Anorexia (HP:0002039)1.92674329
50Vitreoretinal degeneration (HP:0000655)1.92153988
51Anomalous pulmonary venous return (HP:0010772)1.91032958
52Orchitis (HP:0100796)1.88918537
53Bradykinesia (HP:0002067)1.87210835
54Pruritus (HP:0000989)1.82293780
55Increased corneal curvature (HP:0100692)1.82119852
56Keratoconus (HP:0000563)1.82119852
57T lymphocytopenia (HP:0005403)1.81958641
58Inflammation of the large intestine (HP:0002037)1.81353411
59Fasciculations (HP:0002380)1.79843342
60Oculomotor apraxia (HP:0000657)1.79782133
61Autoimmune thrombocytopenia (HP:0001973)1.78007253
62Dysostosis multiplex (HP:0000943)1.77130821
63Dynein arm defect of respiratory motile cilia (HP:0012255)1.77082103
64Absent/shortened dynein arms (HP:0200106)1.77082103
65Portal hypertension (HP:0001409)1.76341026
66Chronic obstructive pulmonary disease (HP:0006510)1.73997371
67Obstructive lung disease (HP:0006536)1.73997371
68Retinitis pigmentosa (HP:0000510)1.73510349
69Biliary tract neoplasm (HP:0100574)1.73104723
70Atonic seizures (HP:0010819)1.73095872
71Hyperthyroidism (HP:0000836)1.72234927
72Macular degeneration (HP:0000608)1.71082647
73Vertigo (HP:0002321)1.70499766
74Microcytic anemia (HP:0001935)1.70005892
75Abnormal respiratory motile cilium physiology (HP:0012261)1.69665606
76Abnormality of the pulmonary veins (HP:0011718)1.69405284
77Myoclonus (HP:0001336)1.66950048
78Aplasia/Hypoplasia of the macula (HP:0008059)1.66831974
79Urinary glycosaminoglycan excretion (HP:0003541)1.65368899
80Mucopolysacchariduria (HP:0008155)1.65368899
81Hemiplegia (HP:0002301)1.64089075
82Gastrointestinal inflammation (HP:0004386)1.61995141
83Dysmetria (HP:0001310)1.61876675
84Decreased electroretinogram (ERG) amplitude (HP:0000654)1.61627097
85Abnormality of polysaccharide metabolism (HP:0011012)1.60257765
86Abnormality of glycosaminoglycan metabolism (HP:0004371)1.60257765
87Abnormality of mucopolysaccharide metabolism (HP:0011020)1.60257765
88Severe Myopia (HP:0011003)1.59597319
89Myositis (HP:0100614)1.59168926
90Generalized hypopigmentation of hair (HP:0011358)1.58374695
91Hyperventilation (HP:0002883)1.56341133
92Increased IgM level (HP:0003496)1.56126064
93Aplasia/Hypoplasia of the fovea (HP:0008060)1.56031980
94Hypoplasia of the fovea (HP:0007750)1.56031980
95Aplasia/Hypoplasia affecting the retina (HP:0008061)1.53119204
96Hypoproteinemia (HP:0003075)1.52883817
97Fused cervical vertebrae (HP:0002949)1.50797615
98Increased density of long bones (HP:0006392)1.50648589
99Abnormal delayed hypersensitivity skin test (HP:0002963)1.50628566
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.50353358

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OXSR15.67812916
2FRK4.26405122
3TXK2.45388164
4WNK42.43367565
5ADRBK22.32389665
6TNK22.22655517
7MAP3K72.10943582
8CDK1910.8314644
9GRK11.96052490
10IKBKE1.82046576
11ZAK1.78953232
12GRK71.77802353
13ACVR1B1.64966302
14STK391.64726710
15ALK1.59232248
16TYK21.58812268
17BMPR21.47687900
18RPS6KB21.43537016
19JAK11.36765989
20JAK31.33869017
21BRSK11.17004361
22JAK21.08948240
23TLK11.04673587
24MELK1.02245685
25KIT0.98324107
26IKBKB0.96055245
27MAPK110.94625200
28IRAK30.92139905
29STK30.91686105
30BMPR1B0.91601536
31RIPK40.87893385
32TBK10.85834234
33MAP4K10.83224945
34MATK0.80457252
35TAOK30.79596536
36BLK0.76361418
37PINK10.76206446
38PDPK10.70670237
39BCR0.68206710
40WNK10.67124019
41IRAK40.65282872
42STK110.64987625
43PDK10.64406364
44BTK0.63723904
45CHUK0.63414733
46MAP3K140.62933940
47FGFR40.62410789
48STK380.62303043
49FER0.61915833
50MKNK10.56261324
51CSK0.55950590
52CDK40.55536331
53PKN10.55277110
54RPS6KA50.54397820
55RIPK10.52889937
56MKNK20.50185719
57HIPK20.46485396
58TGFBR10.46151021
59MAP3K50.46084916
60PIM10.45196025
61CDC42BPA0.43138951
62ITK0.42007510
63TAOK20.38722780
64FGFR30.38408840
65ABL20.37033082
66MST1R0.36884833
67MTOR0.36772965
68MAPKAPK50.36415589
69CHEK20.36182928
70STK100.34387729
71CHEK10.33146523
72MAP2K60.31944527
73ADRBK10.31049511
74LYN0.29745187
75PRKCQ0.27473917
76LCK0.26200166
77PRKAA20.25594727
78NME20.24943170
79CDK11A0.24677021
80AURKA0.24671113
81CAMKK20.23905654
82MAPK70.23568451
83ABL10.23256748
84CDK150.22316916
85CSNK1A10.21910962
86PIM20.21300938
87CDK180.19699332
88PRPF4B0.19097131
89DAPK20.17863660
90ERBB20.16839816
91IGF1R0.16380614
92ZAP700.16138212
93KDR0.15034745
94GRK60.14453649
95PAK10.14417534
96VRK20.14394243
97DDR20.14367666
98RPS6KA40.12085321
99BMX0.11569175
100TESK20.11284786

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001207.35643529
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.52076413
3Allograft rejection_Homo sapiens_hsa053302.60250689
4Autoimmune thyroid disease_Homo sapiens_hsa053202.53165053
5Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.45570165
6Graft-versus-host disease_Homo sapiens_hsa053322.41776824
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.37409768
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.21264917
9Caffeine metabolism_Homo sapiens_hsa002322.10751409
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04341777
11Influenza A_Homo sapiens_hsa051642.04120469
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.97165442
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.95592125
14Hepatitis C_Homo sapiens_hsa051601.95457464
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.88880500
16Herpes simplex infection_Homo sapiens_hsa051681.87688849
17Retinol metabolism_Homo sapiens_hsa008301.77028667
18Type I diabetes mellitus_Homo sapiens_hsa049401.67216418
19Fatty acid biosynthesis_Homo sapiens_hsa000611.62489122
20Measles_Homo sapiens_hsa051621.59126610
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.57618649
22Asthma_Homo sapiens_hsa053101.53804375
23Tryptophan metabolism_Homo sapiens_hsa003801.51860747
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.49616775
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41540541
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.41528096
27African trypanosomiasis_Homo sapiens_hsa051431.35090104
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.34055361
29TNF signaling pathway_Homo sapiens_hsa046681.21049294
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18468947
31Rheumatoid arthritis_Homo sapiens_hsa053231.16748073
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10493540
33Butanoate metabolism_Homo sapiens_hsa006501.08622841
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06676689
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05927599
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04431862
37Staphylococcus aureus infection_Homo sapiens_hsa051501.01801167
38Ether lipid metabolism_Homo sapiens_hsa005651.01492699
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00298144
40Leishmaniasis_Homo sapiens_hsa051401.00047089
41Olfactory transduction_Homo sapiens_hsa047400.99629440
42* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98150511
43Osteoclast differentiation_Homo sapiens_hsa043800.92123548
44Malaria_Homo sapiens_hsa051440.90906936
45* Jak-STAT signaling pathway_Homo sapiens_hsa046300.90084275
46Primary immunodeficiency_Homo sapiens_hsa053400.89804901
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89161146
48Hematopoietic cell lineage_Homo sapiens_hsa046400.81996306
49Pertussis_Homo sapiens_hsa051330.79513394
50Lysosome_Homo sapiens_hsa041420.75952307
51Viral myocarditis_Homo sapiens_hsa054160.75593624
52Antigen processing and presentation_Homo sapiens_hsa046120.72312039
53T cell receptor signaling pathway_Homo sapiens_hsa046600.72048603
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70892296
55Starch and sucrose metabolism_Homo sapiens_hsa005000.68960740
56PPAR signaling pathway_Homo sapiens_hsa033200.67603523
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.65647683
58Tuberculosis_Homo sapiens_hsa051520.63151621
59Chemical carcinogenesis_Homo sapiens_hsa052040.62996903
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62280224
61Linoleic acid metabolism_Homo sapiens_hsa005910.61715441
62Other glycan degradation_Homo sapiens_hsa005110.61223915
63Legionellosis_Homo sapiens_hsa051340.60210660
64Toxoplasmosis_Homo sapiens_hsa051450.60128891
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59531976
66Renin-angiotensin system_Homo sapiens_hsa046140.56832721
67RNA polymerase_Homo sapiens_hsa030200.56607543
68Chemokine signaling pathway_Homo sapiens_hsa040620.56064535
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54469238
70ABC transporters_Homo sapiens_hsa020100.50596189
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.49468537
72Salmonella infection_Homo sapiens_hsa051320.47001260
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.43367681
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42674685
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42407951
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40660610
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35359814
78B cell receptor signaling pathway_Homo sapiens_hsa046620.32116119
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31019040
80Sphingolipid metabolism_Homo sapiens_hsa006000.29420727
81Insulin resistance_Homo sapiens_hsa049310.29236482
82Hepatitis B_Homo sapiens_hsa051610.29000949
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27705081
84Apoptosis_Homo sapiens_hsa042100.25825955
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25495503
86Rap1 signaling pathway_Homo sapiens_hsa040150.25100841
87Type II diabetes mellitus_Homo sapiens_hsa049300.23558044
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22623573
89MAPK signaling pathway_Homo sapiens_hsa040100.21995418
90Complement and coagulation cascades_Homo sapiens_hsa046100.20550092
91Epstein-Barr virus infection_Homo sapiens_hsa051690.20414158
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19164985
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17856438
94Renal cell carcinoma_Homo sapiens_hsa052110.16748002
95N-Glycan biosynthesis_Homo sapiens_hsa005100.16054802
96HTLV-I infection_Homo sapiens_hsa051660.14274426
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.14059221
98Prolactin signaling pathway_Homo sapiens_hsa049170.13126385
99Arachidonic acid metabolism_Homo sapiens_hsa005900.12957468
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12509815

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