ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of cardiac muscle cell differentiation (GO:2000727)	8.45969500
2	positive regulation of digestive system process (GO:0060456)	7.47525651
3	epithelial cell differentiation involved in kidney development (GO:0035850)	6.05558372
4	tryptophan metabolic process (GO:0006568)	5.94052779
5	positive regulation of cAMP-mediated signaling (GO:0043950)	5.79652806
6	negative regulation of multicellular organism growth (GO:0040015)	5.34147627
7	regulation of cardiac muscle cell contraction (GO:0086004)	5.30915550
8	positive regulation of systemic arterial blood pressure (GO:0003084)	5.30064274
9	somatic diversification of immune receptors via somatic mutation (GO:0002566)	5.27389833
10	somatic hypermutation of immunoglobulin genes (GO:0016446)	5.27389833
11	negative regulation of glycogen biosynthetic process (GO:0045719)	5.23491257
12	negative regulation of systemic arterial blood pressure (GO:0003085)	5.15715006
13	negative regulation of peptidyl-lysine acetylation (GO:2000757)	5.02079442
14	regulation of glomerulus development (GO:0090192)	4.80722869
15	regulation of cardiac muscle cell differentiation (GO:2000725)	4.76065167
16	cytidine deamination (GO:0009972)	4.45143354
17	cytidine metabolic process (GO:0046087)	4.45143354
18	cytidine catabolic process (GO:0006216)	4.45143354
19	negative regulation of protein acetylation (GO:1901984)	4.43079287
20	negative regulation of smooth muscle contraction (GO:0045986)	4.39728711
21	sulfation (GO:0051923)	4.38726796
22	cardiac muscle adaptation (GO:0014887)	4.32847225
23	cardiac muscle hypertrophy in response to stress (GO:0014898)	4.32847225
24	muscle hypertrophy in response to stress (GO:0003299)	4.32847225
25	replicative senescence (GO:0090399)	4.30858730
26	serotonin metabolic process (GO:0042428)	4.28506782
27	DNA deamination (GO:0045006)	4.23593883
28	positive regulation of triglyceride biosynthetic process (GO:0010867)	4.19828551
29	cerebellar Purkinje cell differentiation (GO:0021702)	4.19530585
30	pharyngeal system development (GO:0060037)	4.17450871
31	estrogen metabolic process (GO:0008210)	4.16489158
32	indolalkylamine metabolic process (GO:0006586)	4.15919980
33	tyrosine metabolic process (GO:0006570)	4.15896695
34	UDP-N-acetylglucosamine metabolic process (GO:0006047)	4.07935659
35	regulation of actin filament-based movement (GO:1903115)	4.05635684
36	lung morphogenesis (GO:0060425)	4.04126032
37	negative regulation of gene silencing (GO:0060969)	4.04059144
38	DNA replication-dependent nucleosome assembly (GO:0006335)	3.98793629
39	DNA replication-dependent nucleosome organization (GO:0034723)	3.98793629
40	negative regulation of glycogen metabolic process (GO:0070874)	3.97753190
41	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.96297518
42	negative regulation of B cell apoptotic process (GO:0002903)	3.77054951
43	regulation of cardiac muscle tissue growth (GO:0055021)	3.75679390
44	regulation of cell proliferation involved in kidney development (GO:1901722)	3.68757676
45	adrenergic receptor signaling pathway (GO:0071875)	3.68414683
46	cell proliferation in forebrain (GO:0021846)	3.65459181
47	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.64404453
48	primary amino compound metabolic process (GO:1901160)	3.63401318
49	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.58102474
50	opioid receptor signaling pathway (GO:0038003)	3.52090345
51	regulation of urine volume (GO:0035809)	3.48806693
52	cell migration involved in gastrulation (GO:0042074)	3.47916521
53	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.45456987
54	NADH dehydrogenase complex assembly (GO:0010257)	3.45456987
55	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.45456987
56	cellular response to ATP (GO:0071318)	3.45268651
57	positive regulation of icosanoid secretion (GO:0032305)	3.43293439
58	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.39892001
59	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.39892001
60	cellular response to interferon-beta (GO:0035458)	3.38615104
61	tryptophan catabolic process (GO:0006569)	3.36608063
62	indole-containing compound catabolic process (GO:0042436)	3.36608063
63	indolalkylamine catabolic process (GO:0046218)	3.36608063
64	negative regulation of muscle contraction (GO:0045932)	3.32993426
65	regulation of digestive system process (GO:0044058)	3.32935261
66	release of cytochrome c from mitochondria (GO:0001836)	3.31792782
67	positive regulation of fatty acid transport (GO:2000193)	3.31681718
68	regulation of phospholipid biosynthetic process (GO:0071071)	3.30864582
69	respiratory tube development (GO:0030323)	3.27964797
70	metallo-sulfur cluster assembly (GO:0031163)	3.27389707
71	iron-sulfur cluster assembly (GO:0016226)	3.27389707
72	indole-containing compound metabolic process (GO:0042430)	3.26841246
73	regulation of syncytium formation by plasma membrane fusion (GO:0060142)	3.24759527
74	response to interferon-beta (GO:0035456)	3.23056873
75	regulation of cardiac muscle tissue development (GO:0055024)	3.22755283
76	branching involved in labyrinthine layer morphogenesis (GO:0060670)	3.20062787
77	positive regulation of metanephros development (GO:0072216)	3.17956359
78	positive regulation of cardiac muscle hypertrophy (GO:0010613)	3.17015855
79	positive regulation of muscle hypertrophy (GO:0014742)	3.17015855
80	regulation of heart growth (GO:0060420)	3.16438664
81	positive regulation of prostaglandin secretion (GO:0032308)	3.14069283
82	cardiac muscle hypertrophy (GO:0003300)	3.11187001
83	somatic diversification of immunoglobulins (GO:0016445)	3.09815848
84	positive regulation of cardiac muscle tissue development (GO:0055025)	3.09461861
85	muscle hypertrophy (GO:0014896)	3.09136785
86	kynurenine metabolic process (GO:0070189)	3.08446037
87	negative regulation of metanephros development (GO:0072217)	3.07627555
88	pericardium development (GO:0060039)	3.07048782
89	lung secretory cell differentiation (GO:0061140)	3.05326038
90	protein complex biogenesis (GO:0070271)	3.03966741
91	mitochondrial respiratory chain complex assembly (GO:0033108)	2.99987326
92	molting cycle (GO:0042303)	2.99202209
93	hair cycle (GO:0042633)	2.99202209
94	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.98753989
95	regulation of apoptotic process involved in morphogenesis (GO:1902337)	2.98158522
96	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.97764718
97	negative regulation of cardiac muscle tissue development (GO:0055026)	2.97587353
98	cell wall macromolecule catabolic process (GO:0016998)	2.95369271
99	positive regulation of heart rate (GO:0010460)	2.93854037
100	striated muscle hypertrophy (GO:0014897)	2.92674386

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	7.89824979
2	STAT6_21828071_ChIP-Seq_BEAS2B_Human	6.02875433
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	5.08229705
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.72166032
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.57191526
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.38318936
7	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.20939567
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	13.6938148
9	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.92392900
10	SCL_19346495_ChIP-Seq_HPC-7_Human	1.86622337
11	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.77434689
12	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.64148178
13	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.61182620
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.53091184
15	CIITA_25753668_ChIP-Seq_RAJI_Human	1.47534963
16	VDR_21846776_ChIP-Seq_THP-1_Human	1.34720046
17	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.33739725
18	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30875125
19	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.24584113
20	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.24279934
21	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.23903212
22	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.22160930
23	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.22152108
24	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.20539109
25	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.19046091
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.14910319
27	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.11764503
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.10741133
29	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.10139831
30	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06428359
31	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.05249279
32	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.04351600
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.03802133
34	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.02894591
35	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.02820908
36	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.02053841
37	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.00203433
38	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.99511907
39	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.99091716
40	ETS1_22383799_ChIP-Seq_G1ME_Mouse	0.98467158
41	RUNX_20019798_ChIP-Seq_JUKART_Human	0.97338367
42	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.95349926
43	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.93696699
44	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93364355
45	UTX_26944678_Chip-Seq_JUKART_Human	0.91891572
46	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.91718203
47	VDR_24763502_ChIP-Seq_THP-1_Human	0.90250092
48	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.90092324
49	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.89062531
50	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.88045362
51	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.85651175
52	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.84862263
53	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.84278323
54	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.83157244
55	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.83129041
56	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.80506733
57	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.79949053
58	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.79733430
59	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.79682377
60	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.79597331
61	P68_20966046_ChIP-Seq_HELA_Human	0.79468857
62	VDR_23849224_ChIP-Seq_CD4+_Human	0.78628500
63	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.78111588
64	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.75586514
65	TP53_16413492_ChIP-PET_HCT116_Human	0.75187903
66	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.74432761
67	P300_27268052_Chip-Seq_Bcells_Human	0.74045625
68	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.73668825
69	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.73223376
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.72371842
71	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.72371842
72	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.72143547
73	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.71800997
74	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.71414706
75	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.70587513
76	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.70294210
77	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.69870164
78	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.69846112
79	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.69179802
80	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.69092948
81	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.68428436
82	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.68173224
83	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.67971176
84	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.67042158
85	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.65888549
86	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.65595398
87	BCL6_27268052_Chip-Seq_Bcells_Human	0.65416428
88	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.65386729
89	MYC_18940864_ChIP-ChIP_HL60_Human	0.65236864
90	MYB_26560356_Chip-Seq_TH2_Human	0.65223397
91	GATA3_27048872_Chip-Seq_THYMUS_Human	0.65218005
92	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.64499760
93	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.64447114
94	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.62991657
95	SPI1_20517297_ChIP-Seq_HL60_Human	0.62933572
96	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.62564457
97	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.62386682
98	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.61748232
99	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.61094024
100	TP53_22127205_ChIP-Seq_IMR90_Human	0.61090723

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	5.08536096
2	MP0005171_absent_coat_pigmentation	4.85474257
3	MP0009697_abnormal_copulation	4.07709098
4	MP0005083_abnormal_biliary_tract	4.07103328
5	MP0000372_irregular_coat_pigmentation	3.99285875
6	MP0002138_abnormal_hepatobiliary_system	3.93578970
7	MP0008872_abnormal_physiological_respon	3.17555627
8	MP0005379_endocrine/exocrine_gland_phen	2.77586828
9	MP0005503_abnormal_tendon_morphology	2.65242783
10	MP0002160_abnormal_reproductive_system	2.49786724
11	MP0001835_abnormal_antigen_presentation	2.34085202
12	MP0001348_abnormal_lacrimal_gland	2.21600540
13	MP0005646_abnormal_pituitary_gland	2.16816821
14	MP0003638_abnormal_response/metabolism_	2.10685143
15	MP0009384_cardiac_valve_regurgitation	1.98453872
16	MP0004134_abnormal_chest_morphology	1.96335641
17	MP0004145_abnormal_muscle_electrophysio	1.89781725
18	MP0000678_abnormal_parathyroid_gland	1.85297595
19	MP0000537_abnormal_urethra_morphology	1.82414010
20	MP0005389_reproductive_system_phenotype	1.81080366
21	MP0003279_aneurysm	1.75799878
22	MP0009053_abnormal_anal_canal	1.63405543
23	MP0002163_abnormal_gland_morphology	1.63127012
24	MP0000049_abnormal_middle_ear	1.61998856
25	MP0002653_abnormal_ependyma_morphology	1.61448192
26	MP0003724_increased_susceptibility_to	1.51977933
27	MP0006292_abnormal_olfactory_placode	1.51756343
28	MP0002249_abnormal_larynx_morphology	1.50172679
29	MP0005670_abnormal_white_adipose	1.49221295
30	MP0003567_abnormal_fetal_cardiomyocyte	1.45610435
31	MP0001790_abnormal_immune_system	1.42425670
32	MP0005387_immune_system_phenotype	1.42425670
33	MP0002277_abnormal_respiratory_mucosa	1.39551316
34	MP0000631_abnormal_neuroendocrine_gland	1.36084496
35	MP0002837_dystrophic_cardiac_calcinosis	1.34909302
36	MP0002295_abnormal_pulmonary_circulatio	1.34601662
37	MP0000685_abnormal_immune_system	1.32035097
38	MP0002928_abnormal_bile_duct	1.29114075
39	MP0010094_abnormal_chromosome_stability	1.28998395
40	MP0000613_abnormal_salivary_gland	1.25234337
41	MP0008438_abnormal_cutaneous_collagen	1.18036008
42	MP0001485_abnormal_pinna_reflex	1.17040842
43	MP0009250_abnormal_appendicular_skeleto	1.16502119
44	MP0005275_abnormal_skin_tensile	1.16012811
45	MP0000383_abnormal_hair_follicle	1.15501086
46	MP0001919_abnormal_reproductive_system	1.14180732
47	MP0001853_heart_inflammation	1.13257129
48	MP0002971_abnormal_brown_adipose	1.10856672
49	MP0003646_muscle_fatigue	1.08351467
50	MP0002108_abnormal_muscle_morphology	1.07023086
51	MP0001800_abnormal_humoral_immune	1.03314272
52	MP0000681_abnormal_thyroid_gland	1.02196178
53	MP0008058_abnormal_DNA_repair	0.94808160
54	MP0002166_altered_tumor_susceptibility	0.92288998
55	MP0005084_abnormal_gallbladder_morpholo	0.90884646
56	MP0001819_abnormal_immune_cell	0.90668189
57	MP0002420_abnormal_adaptive_immunity	0.89872049
58	MP0008569_lethality_at_weaning	0.89376122
59	MP0002452_abnormal_antigen_presenting	0.88061130
60	MP0000371_diluted_coat_color	0.87663146
61	MP0003119_abnormal_digestive_system	0.86997574
62	MP0002006_tumorigenesis	0.86421920
63	MP0002075_abnormal_coat/hair_pigmentati	0.84056956
64	MP0009764_decreased_sensitivity_to	0.81994198
65	MP0009765_abnormal_xenobiotic_induced	0.81318013
66	MP0005025_abnormal_response_to	0.80676792
67	MP0002723_abnormal_immune_serum	0.79974781
68	MP0002098_abnormal_vibrissa_morphology	0.79606413
69	MP0005535_abnormal_body_temperature	0.79172739
70	MP0002148_abnormal_hypersensitivity_rea	0.79073819
71	MP0002932_abnormal_joint_morphology	0.78111880
72	MP0002282_abnormal_trachea_morphology	0.77655894
73	MP0003786_premature_aging	0.76459138
74	MP0005409_darkened_coat_color	0.76353931
75	MP0003936_abnormal_reproductive_system	0.76286581
76	MP0005508_abnormal_skeleton_morphology	0.76039192
77	MP0000733_abnormal_muscle_development	0.74819316
78	MP0001905_abnormal_dopamine_level	0.74452815
79	MP0003436_decreased_susceptibility_to	0.74213169
80	MP0000716_abnormal_immune_system	0.73914509
81	MP0003937_abnormal_limbs/digits/tail_de	0.73626218
82	MP0005000_abnormal_immune_tolerance	0.72909712
83	MP0009115_abnormal_fat_cell	0.72253212
84	MP0005408_hypopigmentation	0.72048276
85	MP0000689_abnormal_spleen_morphology	0.71971757
86	MP0002089_abnormal_postnatal_growth/wei	0.71728140
87	MP0000639_abnormal_adrenal_gland	0.71386165
88	MP0005410_abnormal_fertilization	0.71159612
89	MP0005671_abnormal_response_to	0.69550150
90	MP0004130_abnormal_muscle_cell	0.68664517
91	MP0005390_skeleton_phenotype	0.68038550
92	MP0001186_pigmentation_phenotype	0.67539927
93	MP0002398_abnormal_bone_marrow	0.65826823
94	MP0003191_abnormal_cellular_cholesterol	0.64215354
95	MP0005360_urolithiasis	0.63084000
96	MP0000627_abnormal_mammary_gland	0.62962096
97	MP0006072_abnormal_retinal_apoptosis	0.59868501
98	MP0003315_abnormal_perineum_morphology	0.58489053
99	MP0000516_abnormal_urinary_system	0.57382318
100	MP0005367_renal/urinary_system_phenotyp	0.57382318

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Anomalous pulmonary venous return (HP:0010772)	6.23595661
2	Abnormality of the pulmonary veins (HP:0011718)	5.83527185
3	Short phalanx of the thumb (HP:0009660)	4.67511332
4	Hypothermia (HP:0002045)	4.03470168
5	Abnormality of the proximal phalanges of the hand (HP:0009834)	3.95943088
6	Calf muscle hypertrophy (HP:0008981)	3.79292406
7	Type II lissencephaly (HP:0007260)	3.68931293
8	Short 4th metacarpal (HP:0010044)	3.60068255
9	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	3.60068255
10	Pendular nystagmus (HP:0012043)	3.56064085
11	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	3.54738828
12	Neoplasm of the heart (HP:0100544)	3.52522648
13	Hyperglycinemia (HP:0002154)	3.33571175
14	Hypoplasia of the uterus (HP:0000013)	3.32147444
15	Muscle hypertrophy of the lower extremities (HP:0008968)	3.32031235
16	Abnormality of the nasal septum (HP:0000419)	3.20793858
17	Abnormality of DNA repair (HP:0003254)	3.18418209
18	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	3.15727310
19	Short 1st metacarpal (HP:0010034)	3.15727310
20	Redundant skin (HP:0001582)	3.10193364
21	Genetic anticipation (HP:0003743)	3.08082908
22	Abnormality of the parietal bone (HP:0002696)	3.01627895
23	Spontaneous hematomas (HP:0007420)	2.98546997
24	Abnormality of the middle phalanges of the toes (HP:0010183)	2.98065688
25	3-Methylglutaconic aciduria (HP:0003535)	2.93866939
26	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.92078541
27	Vertebral fusion (HP:0002948)	2.91338824
28	Oral leukoplakia (HP:0002745)	2.89531679
29	Decreased subcutaneous fat (HP:0001002)	2.86117760
30	Keratoconus (HP:0000563)	2.80590177
31	Increased corneal curvature (HP:0100692)	2.80590177
32	Down-sloping shoulders (HP:0200021)	2.80128928
33	Abnormality of the 1st metacarpal (HP:0010009)	2.77048962
34	Porencephaly (HP:0002132)	2.77032039
35	Hemiplegia (HP:0002301)	2.73279774
36	IgG deficiency (HP:0004315)	2.71292376
37	Ureteral obstruction (HP:0006000)	2.67412571
38	Deformed sella turcica (HP:0002681)	2.64127572
39	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.62229488
40	Cerebellar dysplasia (HP:0007033)	2.58852657
41	Posterior subcapsular cataract (HP:0007787)	2.57177135
42	Morphological abnormality of the middle ear (HP:0008609)	2.56657481
43	Severe muscular hypotonia (HP:0006829)	2.54710074
44	Fatigable weakness (HP:0003473)	2.53857866
45	Abnormality of the neuromuscular junction (HP:0003398)	2.53857866
46	Abnormality of the 4th metacarpal (HP:0010012)	2.52723622
47	Conjunctival hamartoma (HP:0100780)	2.48321727
48	Short humerus (HP:0005792)	2.46296985
49	Facial shape deformation (HP:0011334)	2.44493517
50	Potter facies (HP:0002009)	2.44493517
51	Abnormality of the carotid arteries (HP:0005344)	2.39422068
52	Visual hallucinations (HP:0002367)	2.37895193
53	Elevated erythrocyte sedimentation rate (HP:0003565)	2.36923934
54	Aplasia/hypoplasia of the humerus (HP:0006507)	2.31618708
55	Aplasia/hypoplasia of the uterus (HP:0008684)	2.30021537
56	Death in childhood (HP:0003819)	2.29943321
57	Hamartoma of the eye (HP:0010568)	2.28118988
58	Chorioretinal atrophy (HP:0000533)	2.25650520
59	Adrenal hypoplasia (HP:0000835)	2.24733403
60	Carpal synostosis (HP:0009702)	2.24549795
61	Proximal amyotrophy (HP:0007126)	2.22138069
62	Broad ribs (HP:0000885)	2.20710083
63	Severe visual impairment (HP:0001141)	2.19896711
64	Short hallux (HP:0010109)	2.18712563
65	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.17225057
66	Progressive cerebellar ataxia (HP:0002073)	2.16465656
67	Short femoral neck (HP:0100864)	2.13076642
68	Hypoplasia of the pons (HP:0012110)	2.12908623
69	Short thumb (HP:0009778)	2.10989099
70	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.09009970
71	Hyperglycinuria (HP:0003108)	2.06975858
72	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.06516258
73	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.05184751
74	Synostosis of carpal bones (HP:0005048)	2.04568844
75	Abnormality of subcutaneous fat tissue (HP:0001001)	2.02532008
76	Abnormality of binocular vision (HP:0011514)	2.01878794
77	Diplopia (HP:0000651)	2.01878794
78	Hepatocellular necrosis (HP:0001404)	2.00294219
79	Vitreoretinal degeneration (HP:0000655)	1.99194265
80	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.98727200
81	Supernumerary bones of the axial skeleton (HP:0009144)	1.97510773
82	Orthostatic hypotension (HP:0001278)	1.97333381
83	Spinal muscular atrophy (HP:0007269)	1.96413863
84	Arterial tortuosity (HP:0005116)	1.95592046
85	Goiter (HP:0000853)	1.90773889
86	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.90507475
87	Supernumerary ribs (HP:0005815)	1.90219187
88	Concave nail (HP:0001598)	1.90180179
89	Abolished electroretinogram (ERG) (HP:0000550)	1.89169062
90	Confusion (HP:0001289)	1.88717938
91	Congenital stationary night blindness (HP:0007642)	1.86665650
92	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.85458430
93	Pigmentary retinal degeneration (HP:0001146)	1.85278372
94	Abnormality of ocular smooth pursuit (HP:0000617)	1.85215164
95	Waddling gait (HP:0002515)	1.83570820
96	Synostosis involving bones of the hand (HP:0004278)	1.83540553
97	Abnormality of the humerus (HP:0003063)	1.82658123
98	Delayed closure of the anterior fontanelle (HP:0001476)	1.82568065
99	Abnormality of the columella (HP:0009929)	1.81603282
100	Tarsal synostosis (HP:0008368)	1.80627673

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPKAPK3	4.18295795
2	VRK2	3.82714905
3	MAP3K11	3.35980104
4	EPHA3	3.25496302
5	BCKDK	3.23704541
6	TAF1	2.83510141
7	MAP4K1	2.70479748
8	GRK1	2.51735646
9	VRK1	2.49883471
10	PRKCH	2.43792856
11	FLT3	2.36797625
12	ADRBK2	2.26350569
13	MAP2K3	2.16358787
14	EEF2K	2.08368082
15	ERN1	2.08026217
16	PRKCI	1.97140232
17	NUAK1	1.89439458
18	BMPR1B	1.88706791
19	SMG1	1.86631387
20	PKN2	1.83942760
21	TAOK3	1.82322205
22	PTK2B	1.72346197
23	MAP2K4	1.70059795
24	KIT	1.66773935
25	MAP2K7	1.65820299
26	AURKA	1.65524467
27	PIM2	1.59988243
28	PRKAA1	1.50280354
29	MAPKAPK5	1.33947603
30	IKBKB	1.32745898
31	MAPK11	1.30561049
32	DAPK3	1.27601751
33	SIK1	1.26169050
34	GRK5	1.25626196
35	DAPK1	1.25004262
36	CSF1R	1.19330415
37	PIK3CG	1.14896095
38	PRKD2	1.13673036
39	MAP2K6	1.13664778
40	MAP3K4	1.01253880
41	CSNK1G2	1.00771702
42	PINK1	0.93872354
43	MAPK13	0.92477345
44	GRK6	0.91654283
45	RPS6KB2	0.91552373
46	PRKCQ	0.89070769
47	RPS6KA5	0.85448142
48	ZAK	0.85302529
49	ICK	0.84001743
50	CDK9	0.83423380
51	CSNK1G3	0.82714621
52	CDK19	0.82603890
53	CSNK1A1L	0.81067966
54	STK4	0.78410002
55	ABL2	0.77333158
56	TRPM7	0.74444099
57	PIM1	0.71618734
58	DYRK3	0.70320329
59	ARAF	0.68512201
60	BTK	0.66638100
61	MAPK12	0.65299683
62	RPS6KA6	0.64914110
63	TLK1	0.64650944
64	ATR	0.61873047
65	RPS6KB1	0.60788776
66	PRKCG	0.60144187
67	EIF2AK2	0.60136684
68	CSNK1G1	0.60115454
69	CSK	0.59821138
70	LYN	0.56112633
71	BLK	0.55331179
72	MAP3K8	0.54929538
73	TESK2	0.53696525
74	BRAF	0.53601427
75	CAMK2B	0.53367293
76	FES	0.49111565
77	RPS6KA2	0.48783542
78	HCK	0.47351005
79	MELK	0.45399812
80	MAP3K9	0.45115171
81	RPS6KL1	0.45069356
82	RPS6KC1	0.45069356
83	HIPK2	0.44357488
84	KDR	0.39821359
85	PRKCE	0.39426993
86	PRKCZ	0.38387976
87	DAPK2	0.37115135
88	MAP3K12	0.36937972
89	SCYL2	0.34949749
90	PDK1	0.34130655
91	MUSK	0.32423642
92	TBK1	0.31800949
93	GRK7	0.31477850
94	DYRK2	0.30619811
95	AURKB	0.29666891
96	CLK1	0.29533677
97	LCK	0.28216344
98	PLK2	0.27995617
99	CSNK1A1	0.27494935
100	SYK	0.27293229

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Systemic lupus erythematosus_Homo sapiens_hsa05322	5.65195406
2	Alcoholism_Homo sapiens_hsa05034	3.41225829
3	Selenocompound metabolism_Homo sapiens_hsa00450	2.88780234
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.70818536
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.61491730
6	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	2.56688558
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.27293287
8	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.15291007
9	Viral carcinogenesis_Homo sapiens_hsa05203	2.10191657
10	Sulfur metabolism_Homo sapiens_hsa00920	2.07294503
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.01982183
12	RNA polymerase_Homo sapiens_hsa03020	2.01745708
13	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.93597928
14	One carbon pool by folate_Homo sapiens_hsa00670	1.86954238
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.78279941
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.71776650
17	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.69763946
18	Homologous recombination_Homo sapiens_hsa03440	1.58136671
19	Chemical carcinogenesis_Homo sapiens_hsa05204	1.55001141
20	DNA replication_Homo sapiens_hsa03030	1.54835753
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.54813491
22	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.53106080
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.52455841
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.51657119
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.46547325
26	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.38996436
27	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.38656175
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.36255516
29	Melanoma_Homo sapiens_hsa05218	1.34161737
30	Histidine metabolism_Homo sapiens_hsa00340	1.33169021
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.27284996
32	Basal cell carcinoma_Homo sapiens_hsa05217	1.24232592
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.19778909
34	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.17412739
35	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.12943860
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.10045542
37	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.09187708
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.05878006
39	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.05340330
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02681820
41	Retinol metabolism_Homo sapiens_hsa00830	1.02051485
42	Sulfur relay system_Homo sapiens_hsa04122	1.00807174
43	Oxidative phosphorylation_Homo sapiens_hsa00190	0.96881054
44	Base excision repair_Homo sapiens_hsa03410	0.96394975
45	Glycerolipid metabolism_Homo sapiens_hsa00561	0.92668143
46	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.91140426
47	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.89488254
48	Graft-versus-host disease_Homo sapiens_hsa05332	0.89386961
49	Nicotine addiction_Homo sapiens_hsa05033	0.87700599
50	Asthma_Homo sapiens_hsa05310	0.86383527
51	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.86003087
52	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.84904120
53	Renin secretion_Homo sapiens_hsa04924	0.83078271
54	Renin-angiotensin system_Homo sapiens_hsa04614	0.81628780
55	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76637139
56	Ribosome_Homo sapiens_hsa03010	0.75245589
57	Parkinsons disease_Homo sapiens_hsa05012	0.74384302
58	Phototransduction_Homo sapiens_hsa04744	0.72181127
59	Pyrimidine metabolism_Homo sapiens_hsa00240	0.71631106
60	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.70585294
61	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.70209442
62	Olfactory transduction_Homo sapiens_hsa04740	0.66534817
63	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.62360004
64	Glutathione metabolism_Homo sapiens_hsa00480	0.61902405
65	Alzheimers disease_Homo sapiens_hsa05010	0.60419341
66	Antigen processing and presentation_Homo sapiens_hsa04612	0.60370372
67	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.59343453
68	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.58532741
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.58221869
70	Allograft rejection_Homo sapiens_hsa05330	0.57794187
71	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.56335441
72	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.54253042
73	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.52516733
74	Insulin resistance_Homo sapiens_hsa04931	0.51523407
75	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.50037957
76	Huntingtons disease_Homo sapiens_hsa05016	0.48732584
77	Salivary secretion_Homo sapiens_hsa04970	0.48607519
78	Herpes simplex infection_Homo sapiens_hsa05168	0.43715818
79	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.40846680
80	RNA degradation_Homo sapiens_hsa03018	0.38707182
81	Tyrosine metabolism_Homo sapiens_hsa00350	0.38597854
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.38561317
83	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.38139066
84	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36082018
85	Gap junction_Homo sapiens_hsa04540	0.35063486
86	MAPK signaling pathway_Homo sapiens_hsa04010	0.32779132
87	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.30935611
88	Galactose metabolism_Homo sapiens_hsa00052	0.30776387
89	Leishmaniasis_Homo sapiens_hsa05140	0.30482246
90	Purine metabolism_Homo sapiens_hsa00230	0.30370237
91	Tuberculosis_Homo sapiens_hsa05152	0.28031232
92	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.26821194
93	Pentose phosphate pathway_Homo sapiens_hsa00030	0.25223593
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.24427429
95	Hepatitis C_Homo sapiens_hsa05160	0.23818924
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.22826033
97	Type I diabetes mellitus_Homo sapiens_hsa04940	0.20335064
98	Pertussis_Homo sapiens_hsa05133	0.19291067
99	Metabolic pathways_Homo sapiens_hsa01100	0.18522016
100	HTLV-I infection_Homo sapiens_hsa05166	0.17806748

IFNL3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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