ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	activated T cell proliferation (GO:0050798)	8.14566894
2	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	7.61458975
3	intestinal cholesterol absorption (GO:0030299)	6.97743271
4	mitotic G1 DNA damage checkpoint (GO:0031571)	6.50405809
5	G1 DNA damage checkpoint (GO:0044783)	6.34043256
6	pyrimidine dimer repair (GO:0006290)	6.17777879
7	anatomical structure regression (GO:0060033)	6.08555793
8	mitotic G1/S transition checkpoint (GO:0044819)	5.82498240
9	glycosphingolipid catabolic process (GO:0046479)	5.28842364
10	glycerophospholipid catabolic process (GO:0046475)	5.14370529
11	negative regulation of digestive system process (GO:0060457)	5.13791193
12	negative regulation of phosphoprotein phosphatase activity (GO:0032515)	4.97896455
13	glycolipid catabolic process (GO:0019377)	4.79250302
14	regulation of cholesterol homeostasis (GO:2000188)	4.71960130
15	drug catabolic process (GO:0042737)	4.67771258
16	protein-chromophore linkage (GO:0018298)	4.66926791
17	regulation of glucocorticoid secretion (GO:2000849)	4.65916853
18	parturition (GO:0007567)	4.62794219
19	negative regulation of cholesterol transport (GO:0032375)	4.60207245
20	negative regulation of sterol transport (GO:0032372)	4.60207245
21	DNA integration (GO:0015074)	4.52661089
22	interferon-gamma secretion (GO:0072643)	4.39519520
23	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	4.34061070
24	pyridine nucleotide biosynthetic process (GO:0019363)	4.33806402
25	nicotinamide nucleotide biosynthetic process (GO:0019359)	4.33806402
26	maintenance of protein location in nucleus (GO:0051457)	4.32279165
27	regulation of non-canonical Wnt signaling pathway (GO:2000050)	4.29641300
28	ceramide catabolic process (GO:0046514)	4.29032656
29	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)	4.22278406
30	reproduction (GO:0000003)	4.20597904
31	pericardium development (GO:0060039)	4.09979025
32	negative regulation of circadian rhythm (GO:0042754)	3.99094645
33	kidney morphogenesis (GO:0060993)	3.93649670
34	SMAD protein complex assembly (GO:0007183)	3.90131388
35	ubiquinone metabolic process (GO:0006743)	3.89757611
36	binding of sperm to zona pellucida (GO:0007339)	3.87742036
37	exogenous drug catabolic process (GO:0042738)	3.85679832
38	positive regulation of developmental pigmentation (GO:0048087)	3.83183527
39	single strand break repair (GO:0000012)	3.78845388
40	regulation of female gonad development (GO:2000194)	3.74304095
41	response to pheromone (GO:0019236)	3.69843712
42	regulation of corticosteroid hormone secretion (GO:2000846)	3.69209936
43	negative regulation of lipid transport (GO:0032369)	3.64420435
44	glycosylceramide metabolic process (GO:0006677)	3.63916662
45	positive regulation of protein homooligomerization (GO:0032464)	3.62338121
46	regulation of MHC class I biosynthetic process (GO:0045343)	3.57600482
47	left/right pattern formation (GO:0060972)	3.57557173
48	sperm-egg recognition (GO:0035036)	3.52484708
49	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.48968600
50	L-phenylalanine catabolic process (GO:0006559)	3.48968600
51	triglyceride homeostasis (GO:0070328)	3.47940867
52	acylglycerol homeostasis (GO:0055090)	3.47940867
53	seminiferous tubule development (GO:0072520)	3.46422081
54	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	3.45305359
55	regulation of pigment cell differentiation (GO:0050932)	3.44504054
56	glycoside metabolic process (GO:0016137)	3.38417618
57	regulation of developmental pigmentation (GO:0048070)	3.38163952
58	glyoxylate metabolic process (GO:0046487)	3.35710426
59	peptidyl-lysine dimethylation (GO:0018027)	3.34541746
60	pyridine-containing compound biosynthetic process (GO:0072525)	3.21948321
61	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.20562879
62	intestinal absorption (GO:0050892)	3.19895744
63	entrainment of circadian clock by photoperiod (GO:0043153)	3.15151463
64	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.13563587
65	artery smooth muscle contraction (GO:0014824)	3.05992391
66	bile acid biosynthetic process (GO:0006699)	3.04959532
67	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	3.01495180
68	cellular response to cholesterol (GO:0071397)	3.00505246
69	Sertoli cell development (GO:0060009)	2.95004409
70	COPII vesicle coating (GO:0048208)	2.93827563
71	NADP metabolic process (GO:0006739)	2.92336474
72	tyrosine metabolic process (GO:0006570)	2.90980675
73	outflow tract septum morphogenesis (GO:0003148)	2.89215592
74	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.88104378
75	L-phenylalanine metabolic process (GO:0006558)	2.88104378
76	serine family amino acid catabolic process (GO:0009071)	2.87922186
77	definitive hemopoiesis (GO:0060216)	2.87293249
78	sphingolipid catabolic process (GO:0030149)	2.87030597
79	regulation of dopamine metabolic process (GO:0042053)	2.84694374
80	regulation of catecholamine metabolic process (GO:0042069)	2.84694374
81	pancreas development (GO:0031016)	2.84619300
82	negative regulation of myeloid cell apoptotic process (GO:0033033)	2.84048092
83	regulation of steroid hormone secretion (GO:2000831)	2.82497767
84	regulation of sequestering of triglyceride (GO:0010889)	2.81327896
85	DNA damage induced protein phosphorylation (GO:0006975)	2.81081153
86	cell-cell recognition (GO:0009988)	2.79237917
87	sterol biosynthetic process (GO:0016126)	2.77271038
88	outer ear morphogenesis (GO:0042473)	2.76507873
89	positive regulation of skeletal muscle tissue development (GO:0048643)	2.74762117
90	phosphatidylethanolamine metabolic process (GO:0046337)	2.73634466
91	regulation of receptor biosynthetic process (GO:0010869)	2.71999969
92	regulation of triglyceride biosynthetic process (GO:0010866)	2.71391716
93	indolalkylamine metabolic process (GO:0006586)	2.69549085
94	sex differentiation (GO:0007548)	2.67661532
95	arginine catabolic process (GO:0006527)	2.67444789
96	leukocyte tethering or rolling (GO:0050901)	2.66158569
97	aromatic amino acid family catabolic process (GO:0009074)	2.65984733
98	tonic smooth muscle contraction (GO:0014820)	2.65810691
99	sexual reproduction (GO:0019953)	11.9410150
100	acrosome assembly (GO:0001675)	11.1820776

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	7.38223977
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.67964425
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.07706206
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.05158791
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.04297962
6	IRF1_19129219_ChIP-ChIP_H3396_Human	2.84597893
7	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.74815965
8	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.71610451
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.67847508
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.51979643
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.43227723
12	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.36634603
13	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.36267072
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.24402458
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.24276182
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.82128243
17	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.80505009
18	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.79663203
19	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.74740560
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.74520079
21	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.67452526
22	EZH2_22144423_ChIP-Seq_EOC_Human	1.66021551
23	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.64064415
24	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.64064415
25	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.64064415
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62436974
27	P300_27268052_Chip-Seq_Bcells_Human	1.61523514
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52896323
29	SOX11_22085726_ChIP-Seq_ESNs_Mouse	1.52759052
30	GATA1_19941826_ChIP-Seq_K562_Human	1.51335261
31	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.51124915
32	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.47392384
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.46526234
34	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45766078
35	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.45548996
36	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.40881003
37	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.40278694
38	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.37763712
39	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.32176466
40	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.31456219
41	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.29359702
42	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.28135862
43	FUS_26573619_Chip-Seq_HEK293_Human	1.27671524
44	GATA1_19941827_ChIP-Seq_MEL86_Mouse	1.26180008
45	CTCF_20526341_ChIP-Seq_ESCs_Human	1.24808727
46	SMRT_27268052_Chip-Seq_Bcells_Human	1.24281417
47	EWS_26573619_Chip-Seq_HEK293_Human	1.22770390
48	P300_19829295_ChIP-Seq_ESCs_Human	1.22632997
49	PHF8_20622854_ChIP-Seq_HELA_Human	1.22067297
50	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.19953953
51	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.19782412
52	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.18372913
53	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.16245863
54	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.15840146
55	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.15377271
56	CEBPB_22108803_ChIP-Seq_LS180_Human	1.12387225
57	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.12294280
58	BCL6_27268052_Chip-Seq_Bcells_Human	1.11038069
59	SPI1_20517297_ChIP-Seq_HL60_Human	1.10757211
60	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.10420405
61	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.10420405
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10049774
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09030131
64	MYC_19829295_ChIP-Seq_ESCs_Human	1.08062436
65	NCOR_22424771_ChIP-Seq_293T_Human	1.06763060
66	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.06299591
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03873744
68	BCOR_27268052_Chip-Seq_Bcells_Human	1.03078627
69	ZNF274_21170338_ChIP-Seq_K562_Hela	1.02571478
70	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.02032237
71	STAT1_20625510_ChIP-Seq_HELA_Human	1.01872845
72	AR_20517297_ChIP-Seq_VCAP_Human	1.01674218
73	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00677964
74	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.99835244
75	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.99654803
76	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.97113669
77	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.96203234
78	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.96096686
79	AR_21572438_ChIP-Seq_LNCaP_Human	0.95447052
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.95318442
81	VDR_24763502_ChIP-Seq_THP-1_Human	0.94593976
82	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.94486961
83	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.94240963
84	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.94183283
85	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.94124982
86	EOMES_21245162_ChIP-Seq_HESCs_Human	0.92407022
87	AR_25329375_ChIP-Seq_VCAP_Human	0.91863692
88	RUNX2_22187159_ChIP-Seq_PCA_Human	0.91676264
89	CDX2_22108803_ChIP-Seq_LS180_Human	0.91034890
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.89705339
91	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.89478060
92	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.89291635
93	ERG_20517297_ChIP-Seq_VCAP_Human	0.89252626
94	CBP_21632823_ChIP-Seq_H3396_Human	0.88929454
95	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.88044021
96	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.87385489
97	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.85327461
98	CTCF_27219007_Chip-Seq_Bcells_Human	0.85317494
99	RUNX_20019798_ChIP-Seq_JUKART_Human	0.85167071
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.84883173

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	9.59759495
2	MP0008995_early_reproductive_senescence	4.75737649
3	MP0001666_abnormal_nutrient_absorption	3.76690927
4	MP0005085_abnormal_gallbladder_physiolo	3.67964078
5	MP0008877_abnormal_DNA_methylation	3.47454289
6	MP0000013_abnormal_adipose_tissue	3.16673319
7	MP0002638_abnormal_pupillary_reflex	3.10476517
8	MP0005365_abnormal_bile_salt	3.08102411
9	MP0005410_abnormal_fertilization	2.99891213
10	MP0001727_abnormal_embryo_implantation	2.33566211
11	MP0003868_abnormal_feces_composition	2.27434816
12	MP0000678_abnormal_parathyroid_gland	2.23294520
13	MP0008004_abnormal_stomach_pH	2.23233456
14	MP0003806_abnormal_nucleotide_metabolis	2.23095432
15	MP0009053_abnormal_anal_canal	2.02876806
16	MP0005360_urolithiasis	1.96599269
17	MP0008875_abnormal_xenobiotic_pharmacok	1.95873687
18	MP0002138_abnormal_hepatobiliary_system	1.95046833
19	MP0005377_hearing/vestibular/ear_phenot	1.93312254
20	MP0003878_abnormal_ear_physiology	1.93312254
21	MP0003195_calcinosis	1.91625059
22	MP0000537_abnormal_urethra_morphology	1.72423751
23	MP0003119_abnormal_digestive_system	1.64371987
24	MP0005220_abnormal_exocrine_pancreas	1.60773900
25	MP0003567_abnormal_fetal_cardiomyocyte	1.57242363
26	MP0000003_abnormal_adipose_tissue	1.50013333
27	MP0001929_abnormal_gametogenesis	1.41969522
28	MP0003698_abnormal_male_reproductive	1.36902085
29	MP0004885_abnormal_endolymph	1.35495471
30	MP0004142_abnormal_muscle_tone	1.34185991
31	MP0005075_abnormal_melanosome_morpholog	1.32287786
32	MP0005647_abnormal_sex_gland	1.27751394
33	MP0000639_abnormal_adrenal_gland	1.22985788
34	MP0004133_heterotaxia	1.22435718
35	MP0003890_abnormal_embryonic-extraembry	1.22328039
36	MP0008873_increased_physiological_sensi	1.17416329
37	MP0000681_abnormal_thyroid_gland	1.16926940
38	MP0000653_abnormal_sex_gland	1.16200128
39	MP0001145_abnormal_male_reproductive	1.13627622
40	MP0006292_abnormal_olfactory_placode	1.09062724
41	MP0002736_abnormal_nociception_after	1.07165641
42	MP0002933_joint_inflammation	1.04281218
43	MP0001340_abnormal_eyelid_morphology	1.03819623
44	MP0002210_abnormal_sex_determination	1.02698914
45	MP0002249_abnormal_larynx_morphology	1.02568786
46	MP0001119_abnormal_female_reproductive	0.99464131
47	MP0003011_delayed_dark_adaptation	0.99438151
48	MP0003943_abnormal_hepatobiliary_system	0.98681777
49	MP0004019_abnormal_vitamin_homeostasis	0.98632418
50	MP0003942_abnormal_urinary_system	0.96632948
51	MP0003786_premature_aging	0.93226365
52	MP0010329_abnormal_lipoprotein_level	0.92911906
53	MP0004264_abnormal_extraembryonic_tissu	0.92314320
54	MP0003186_abnormal_redox_activity	0.90511908
55	MP0003718_maternal_effect	0.89804971
56	MP0003122_maternal_imprinting	0.88414232
57	MP0009765_abnormal_xenobiotic_induced	0.86003247
58	MP0000462_abnormal_digestive_system	0.83647259
59	MP0000516_abnormal_urinary_system	0.82769051
60	MP0005367_renal/urinary_system_phenotyp	0.82769051
61	MP0003699_abnormal_female_reproductive	0.82337683
62	MP0001968_abnormal_touch/_nociception	0.82304284
63	MP0001905_abnormal_dopamine_level	0.80975680
64	MP0002653_abnormal_ependyma_morphology	0.80189260
65	MP0005076_abnormal_cell_differentiation	0.77478941
66	MP0002161_abnormal_fertility/fecundity	0.74004563
67	MP0003936_abnormal_reproductive_system	0.72926263
68	MP0005375_adipose_tissue_phenotype	0.72842468
69	MP0003121_genomic_imprinting	0.71176608
70	MP0001873_stomach_inflammation	0.69581825
71	MP0000477_abnormal_intestine_morphology	0.69274701
72	MP0005266_abnormal_metabolism	0.68785663
73	MP0002332_abnormal_exercise_endurance	0.65173070
74	MP0004782_abnormal_surfactant_physiolog	0.64757314
75	MP0003787_abnormal_imprinting	0.62559970
76	MP0002733_abnormal_thermal_nociception	0.62244814
77	MP0003763_abnormal_thymus_physiology	0.62118628
78	MP0005332_abnormal_amino_acid	0.61903569
79	MP0002938_white_spotting	0.60727668
80	MP0002108_abnormal_muscle_morphology	0.60296981
81	MP0002098_abnormal_vibrissa_morphology	0.60113707
82	MP0001502_abnormal_circadian_rhythm	0.58121883
83	MP0005646_abnormal_pituitary_gland	0.56496723
84	MP0002089_abnormal_postnatal_growth/wei	0.56062678
85	MP0002118_abnormal_lipid_homeostasis	0.55831409
86	MP0003638_abnormal_response/metabolism_	0.53281263
87	MP0000470_abnormal_stomach_morphology	0.52821287
88	MP0005381_digestive/alimentary_phenotyp	0.51771022
89	MP0001764_abnormal_homeostasis	0.47686621
90	MP0002135_abnormal_kidney_morphology	0.47672801
91	MP0009333_abnormal_splenocyte_physiolog	0.44980957
92	MP0005084_abnormal_gallbladder_morpholo	0.43621646
93	MP0002160_abnormal_reproductive_system	0.43620000
94	MP0008872_abnormal_physiological_respon	0.43432118
95	MP0009703_decreased_birth_body	0.42773761
96	MP0002693_abnormal_pancreas_physiology	0.42350483
97	MP0000465_gastrointestinal_hemorrhage	0.41247205
98	MP0005423_abnormal_somatic_nervous	0.40993300
99	MP0002876_abnormal_thyroid_physiology	0.40914849
100	MP0005334_abnormal_fat_pad	0.40689008

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Gonadotropin excess (HP:0000837)	7.89795680
2	Menstrual irregularities (HP:0000858)	6.13141204
3	Male infertility (HP:0003251)	5.10930563
4	Osteomalacia (HP:0002749)	4.89131520
5	Renal dysplasia (HP:0000110)	4.53857624
6	Unilateral renal agenesis (HP:0000122)	4.26932700
7	Chronic hepatic failure (HP:0100626)	4.17905774
8	Hypercholesterolemia (HP:0003124)	4.10738963
9	Follicular hyperkeratosis (HP:0007502)	3.96568829
10	Renal cortical cysts (HP:0000803)	3.91695272
11	Cheilitis (HP:0100825)	3.90358662
12	Abnormal biliary tract physiology (HP:0012439)	3.88429327
13	Bile duct proliferation (HP:0001408)	3.88429327
14	Abnormal tarsal ossification (HP:0008369)	3.84295942
15	Alopecia of scalp (HP:0002293)	3.70844720
16	Tubulointerstitial nephritis (HP:0001970)	3.67166394
17	Parakeratosis (HP:0001036)	3.64986758
18	Infertility (HP:0000789)	3.59543309
19	Increased mean platelet volume (HP:0011877)	3.55361240
20	Rickets (HP:0002748)	3.40595380
21	Abnormal pancreas size (HP:0012094)	3.30951540
22	Prominent supraorbital ridges (HP:0000336)	3.28209902
23	Stenosis of the external auditory canal (HP:0000402)	3.27919405
24	Abnormal platelet volume (HP:0011876)	3.26526972
25	Recurrent corneal erosions (HP:0000495)	3.10670351
26	Renal Fanconi syndrome (HP:0001994)	3.10595410
27	Periauricular skin pits (HP:0100277)	2.99039039
28	Preauricular pit (HP:0004467)	2.99039039
29	Flattened epiphyses (HP:0003071)	2.98924110
30	Renal tubular acidosis (HP:0001947)	2.97237781
31	Enlarged kidneys (HP:0000105)	2.96488069
32	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.84417676
33	Hyperpituitarism (HP:0010514)	2.78547268
34	Abnormality of methionine metabolism (HP:0010901)	2.74309124
35	Abnormality of dental color (HP:0011073)	2.74079044
36	Hip dysplasia (HP:0001385)	2.71358476
37	Polygenic inheritance (HP:0010982)	2.69580132
38	Gonadal dysgenesis (HP:0000133)	2.52864324
39	Absent eyebrow (HP:0002223)	2.51192966
40	Abnormality of male internal genitalia (HP:0000022)	2.44819576
41	Cortical visual impairment (HP:0100704)	2.44492095
42	Cupped ear (HP:0000378)	2.43366975
43	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.40672596
44	White forelock (HP:0002211)	2.40359047
45	Sensorimotor neuropathy (HP:0007141)	2.40060640
46	Abnormality of endocrine pancreas physiology (HP:0012093)	2.39849048
47	Abnormality of the pancreatic islet cells (HP:0006476)	2.39849048
48	Epiphyseal dysplasia (HP:0002656)	2.38973053
49	Delayed epiphyseal ossification (HP:0002663)	2.36925813
50	Hypochromic anemia (HP:0001931)	2.35862854
51	Impaired platelet aggregation (HP:0003540)	2.33049795
52	Abnormal platelet function (HP:0011869)	2.33049795
53	Hypophosphatemic rickets (HP:0004912)	2.31533701
54	Absent eyelashes (HP:0000561)	2.31027249
55	Patchy hypopigmentation of hair (HP:0011365)	2.30749522
56	Tongue fasciculations (HP:0001308)	2.29486713
57	Small epiphyses (HP:0010585)	2.28416676
58	Hypoplastic ischia (HP:0003175)	2.26693298
59	Abnormal foot bone ossification (HP:0010675)	2.26686031
60	Abnormality of renal resorption (HP:0011038)	2.23021043
61	Proximal tubulopathy (HP:0000114)	2.21317685
62	Mitral stenosis (HP:0001718)	2.21130677
63	Hyperphosphaturia (HP:0003109)	2.17052707
64	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	2.16646192
65	Poikilocytosis (HP:0004447)	2.16590141
66	Hyperglycinemia (HP:0002154)	2.12074831
67	Premature ovarian failure (HP:0008209)	2.10097214
68	Long toe (HP:0010511)	2.09987389
69	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.07433303
70	Abolished electroretinogram (ERG) (HP:0000550)	2.07094014
71	Abnormality of the renal cortex (HP:0011035)	2.06465218
72	Depressed nasal tip (HP:0000437)	2.06310738
73	Irregular vertebral endplates (HP:0003301)	2.05314750
74	Generalized amyotrophy (HP:0003700)	2.04582166
75	Blue irides (HP:0000635)	2.01328401
76	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.01304303
77	Tinnitus (HP:0000360)	2.01216094
78	Down-sloping shoulders (HP:0200021)	2.00221264
79	Barrel-shaped chest (HP:0001552)	1.99049398
80	Acute lymphatic leukemia (HP:0006721)	1.97456728
81	Ectropion (HP:0000656)	1.97327127
82	Broad palm (HP:0001169)	1.96060730
83	Muscle fibrillation (HP:0010546)	1.95444143
84	Hypoplastic pelvis (HP:0008839)	1.91760537
85	Acute hepatic failure (HP:0006554)	1.91402491
86	Tubulointerstitial abnormality (HP:0001969)	1.90396084
87	Abnormal urine phosphate concentration (HP:0012599)	1.90383696
88	Abnormality of the 2nd finger (HP:0004100)	1.88799524
89	Male pseudohermaphroditism (HP:0000037)	1.88671069
90	Abnormality of the renal medulla (HP:0100957)	1.86967475
91	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.84881158
92	Reticulocytosis (HP:0001923)	1.84363940
93	Hyperkalemia (HP:0002153)	1.83748149
94	Erythroderma (HP:0001019)	1.81884171
95	Skin pits (HP:0100276)	1.80302562
96	Abnormality of the ischium (HP:0003174)	1.75994833
97	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.74846693
98	Athetosis (HP:0002305)	1.74229559
99	Ileus (HP:0002595)	1.74055754
100	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.73263116

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK3	6.20486023
2	MUSK	5.84830695
3	BMPR1B	5.39837634
4	ACVR1B	5.35442113
5	PRKD3	3.44334882
6	MAP3K6	3.04034496
7	PRPF4B	2.81398483
8	TYRO3	2.57725234
9	TGFBR1	2.48379023
10	TAOK2	2.17864852
11	FES	2.17034020
12	MAP2K4	2.02516429
13	MAP3K4	1.95587960
14	BRD4	1.94258833
15	NLK	1.87637101
16	MAP2K7	1.73729008
17	LATS1	1.61837638
18	SIK1	1.56008723
19	MAPK15	1.41085603
20	VRK2	1.40093168
21	NUAK1	1.34054811
22	STK24	1.31147755
23	MAP2K2	1.23749734
24	MAP3K9	1.20623382
25	MAP2K3	1.16919309
26	CDK8	1.16672298
27	MELK	1.14790404
28	MAP3K5	1.07417008
29	STK3	1.05235166
30	KSR2	1.02558657
31	DYRK1A	1.02329557
32	MAP3K12	1.00209942
33	CDK9	0.96785900
34	PINK1	0.95456491
35	CSF1R	0.88954926
36	EIF2AK2	0.83122781
37	MAP3K2	0.82807980
38	CSK	0.81514387
39	VRK1	0.80204111
40	PLK4	0.80201398
41	RIPK1	0.79212555
42	PIK3CG	0.78299251
43	MAP3K10	0.76867230
44	PRKD2	0.74635593
45	ADRBK2	0.72100468
46	MAPK13	0.71693570
47	TAF1	0.66462073
48	CSNK1G1	0.65494991
49	MAP2K6	0.57058297
50	STK38L	0.56312402
51	RET	0.55023037
52	MAP3K11	0.54005352
53	TIE1	0.52546857
54	CDK4	0.51479288
55	CDK19	0.50486705
56	INSRR	0.49623680
57	MAP2K1	0.45962508
58	IKBKB	0.44495392
59	HIPK2	0.43173419
60	BMX	0.42953719
61	BMPR2	0.41189910
62	TAOK3	0.41139912
63	KIT	0.40096820
64	FLT3	0.39512167
65	PRKCH	0.37346045
66	TYK2	0.31709737
67	MKNK1	0.31588294
68	YES1	0.31185685
69	ATM	0.30869062
70	BCKDK	0.26373281
71	TBK1	0.25853461
72	MAP3K1	0.24569795
73	STK11	0.24449998
74	EPHB2	0.24354863
75	MATK	0.24304138
76	DAPK2	0.24271177
77	LCK	0.22832255
78	IKBKE	0.22503809
79	ADRBK1	0.21825207
80	AKT2	0.21168549
81	SIK2	0.19435595
82	PDGFRB	0.19371301
83	ATR	0.19217960
84	TNK2	0.18511921
85	MKNK2	0.18439516
86	NEK2	0.17793284
87	NEK6	0.17213152
88	PRKCQ	0.16940685
89	CSNK1G3	0.16484200
90	PIM1	0.16042482
91	PAK1	0.15929125
92	GRK6	0.15749894
93	PRKCE	0.15683427
94	SGK1	0.15126393
95	MARK3	0.14706498
96	MAPK1	0.14454590
97	CLK1	0.13778813
98	DAPK3	0.13527534
99	JAK2	0.13380014
100	ARAF	0.11676778

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.46449436
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.89484746
3	Caffeine metabolism_Homo sapiens_hsa00232	3.82374511
4	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.28712381
5	Linoleic acid metabolism_Homo sapiens_hsa00591	3.21096096
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.95692557
7	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.88508261
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.80914556
9	Butanoate metabolism_Homo sapiens_hsa00650	2.59783630
10	Bile secretion_Homo sapiens_hsa04976	2.43639697
11	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.38946767
12	Steroid biosynthesis_Homo sapiens_hsa00100	2.33989874
13	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.29762821
14	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.29018251
15	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	2.24957533
16	Fat digestion and absorption_Homo sapiens_hsa04975	2.13902719
17	Chemical carcinogenesis_Homo sapiens_hsa05204	2.11922275
18	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.96828759
19	Retinol metabolism_Homo sapiens_hsa00830	1.94857581
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.88511015
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.80691328
22	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.75270166
23	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.55838192
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.51916815
25	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.51623950
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.49940037
27	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.36753871
28	ABC transporters_Homo sapiens_hsa02010	1.31043671
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.29368677
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.28999006
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24826633
32	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.24553754
33	Tyrosine metabolism_Homo sapiens_hsa00350	1.23815183
34	Fatty acid elongation_Homo sapiens_hsa00062	1.16283710
35	Pyruvate metabolism_Homo sapiens_hsa00620	1.14451589
36	Prion diseases_Homo sapiens_hsa05020	1.13711605
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.13288648
38	Sphingolipid metabolism_Homo sapiens_hsa00600	1.07695097
39	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.94789919
40	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.90201303
41	Ether lipid metabolism_Homo sapiens_hsa00565	0.89808576
42	Peroxisome_Homo sapiens_hsa04146	0.83505555
43	Pertussis_Homo sapiens_hsa05133	0.80808198
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74144687
45	Olfactory transduction_Homo sapiens_hsa04740	0.73248168
46	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.72891553
47	TNF signaling pathway_Homo sapiens_hsa04668	0.71364482
48	Serotonergic synapse_Homo sapiens_hsa04726	0.68309396
49	Platelet activation_Homo sapiens_hsa04611	0.68117216
50	Circadian rhythm_Homo sapiens_hsa04710	0.65751620
51	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.64482437
52	Complement and coagulation cascades_Homo sapiens_hsa04610	0.64141111
53	PPAR signaling pathway_Homo sapiens_hsa03320	0.62069959
54	Glutathione metabolism_Homo sapiens_hsa00480	0.60383952
55	Metabolic pathways_Homo sapiens_hsa01100	0.60146329
56	Pancreatic cancer_Homo sapiens_hsa05212	0.60089621
57	Basal transcription factors_Homo sapiens_hsa03022	0.58576875
58	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.56616260
59	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.55427700
60	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.54276202
61	Phototransduction_Homo sapiens_hsa04744	0.49793084
62	Long-term depression_Homo sapiens_hsa04730	0.49084245
63	Fatty acid degradation_Homo sapiens_hsa00071	0.48433243
64	Arginine biosynthesis_Homo sapiens_hsa00220	0.44843562
65	Ribosome_Homo sapiens_hsa03010	0.43544070
66	RNA degradation_Homo sapiens_hsa03018	0.43348027
67	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.43026026
68	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.40986132
69	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.40205937
70	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.37925692
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.37559440
72	Legionellosis_Homo sapiens_hsa05134	0.35532568
73	VEGF signaling pathway_Homo sapiens_hsa04370	0.32765077
74	Ras signaling pathway_Homo sapiens_hsa04014	0.32372789
75	Herpes simplex infection_Homo sapiens_hsa05168	0.31756363
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.30336362
77	Acute myeloid leukemia_Homo sapiens_hsa05221	0.29356917
78	Carbon metabolism_Homo sapiens_hsa01200	0.29099811
79	Colorectal cancer_Homo sapiens_hsa05210	0.28603862
80	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.27935502
81	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.26564067
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.23975351
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.22521909
84	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.20509447
85	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.19742331
86	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.19340658
87	Adherens junction_Homo sapiens_hsa04520	0.19331682
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.19226479
89	Allograft rejection_Homo sapiens_hsa05330	0.16653378
90	Type II diabetes mellitus_Homo sapiens_hsa04930	0.16172234
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.13890673
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.13830218
93	Phenylalanine metabolism_Homo sapiens_hsa00360	0.13812041
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.13411643
95	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.13110460
96	Apoptosis_Homo sapiens_hsa04210	0.10930500
97	Hepatitis C_Homo sapiens_hsa05160	0.10853292
98	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.10718849
99	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.10494355
100	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.10155918

IFNL4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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