IFNLR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of bacterium (GO:0016045)7.68981249
2detection of other organism (GO:0098543)6.93038998
3leukocyte aggregation (GO:0070486)6.30698377
4leukocyte migration involved in inflammatory response (GO:0002523)5.47251069
5bundle of His cell to Purkinje myocyte communication (GO:0086069)5.43094165
6defense response to fungus (GO:0050832)5.35642007
7desmosome organization (GO:0002934)5.30780692
8B cell receptor signaling pathway (GO:0050853)5.01680438
9production of molecular mediator involved in inflammatory response (GO:0002532)4.82518838
10regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.52892940
11histone H3-K36 demethylation (GO:0070544)4.49796184
12gonadal mesoderm development (GO:0007506)4.43811012
13hemidesmosome assembly (GO:0031581)4.37918431
14neutrophil mediated immunity (GO:0002446)4.36215153
15detection of external biotic stimulus (GO:0098581)4.33089673
16regulation of water loss via skin (GO:0033561)4.31742017
17establishment of skin barrier (GO:0061436)4.30915464
18regulation of B cell receptor signaling pathway (GO:0050855)4.04189158
19neutrophil activation involved in immune response (GO:0002283)4.02687772
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.99411300
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.95722238
22neutrophil activation (GO:0042119)3.92942891
23antigen processing and presentation of endogenous antigen (GO:0019883)3.92874003
24cellular extravasation (GO:0045123)3.92122443
25sequestering of metal ion (GO:0051238)3.82910818
26regulation of podosome assembly (GO:0071801)3.79247043
27dendritic cell migration (GO:0036336)3.79024890
28B cell proliferation (GO:0042100)3.72661786
29regulation of interferon-beta biosynthetic process (GO:0045357)3.72608630
30dendritic cell chemotaxis (GO:0002407)3.72350279
31positive regulation of mast cell activation (GO:0033005)3.68366230
32detection of biotic stimulus (GO:0009595)3.62869573
33regulation of MHC class I biosynthetic process (GO:0045343)3.58662875
34granulocyte activation (GO:0036230)3.54626985
35positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.54452833
36vitamin transmembrane transport (GO:0035461)3.50441576
37superoxide anion generation (GO:0042554)3.48032802
38multicellular organismal water homeostasis (GO:0050891)3.48022162
39response to type I interferon (GO:0034340)3.45439584
40type I interferon signaling pathway (GO:0060337)3.45237686
41cellular response to type I interferon (GO:0071357)3.45237686
42response to fungus (GO:0009620)3.44837539
43surfactant homeostasis (GO:0043129)3.42919484
44positive regulation of mast cell activation involved in immune response (GO:0033008)3.39855224
45positive regulation of mast cell degranulation (GO:0043306)3.39855224
46chronic inflammatory response (GO:0002544)3.39576042
47regulation of guanylate cyclase activity (GO:0031282)3.33271100
48CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.32055003
49leukotriene metabolic process (GO:0006691)3.30893388
50adhesion of symbiont to host cell (GO:0044650)3.30489863
51virion attachment to host cell (GO:0019062)3.30489863
52immunoglobulin mediated immune response (GO:0016064)3.26561255
53B cell homeostasis (GO:0001782)3.24917499
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.24705138
55keratinocyte differentiation (GO:0030216)3.23998699
56intestinal epithelial cell development (GO:0060576)3.23752009
57myeloid leukocyte mediated immunity (GO:0002444)3.22642739
58actin filament depolymerization (GO:0030042)3.22509874
59positive thymic T cell selection (GO:0045059)3.19220350
60diterpenoid biosynthetic process (GO:0016102)3.18681334
61regulation of natural killer cell differentiation (GO:0032823)3.18222457
62thymic T cell selection (GO:0045061)3.17342009
63chemical homeostasis within a tissue (GO:0048875)3.16121059
64positive regulation of p38MAPK cascade (GO:1900745)3.15408856
65sulfate transmembrane transport (GO:1902358)3.11257633
66positive regulation of protein oligomerization (GO:0032461)3.09990203
67cytidine deamination (GO:0009972)3.09924682
68cytidine metabolic process (GO:0046087)3.09924682
69cytidine catabolic process (GO:0006216)3.09924682
70positive regulation of protein homooligomerization (GO:0032464)3.08969159
71regulation of bile acid biosynthetic process (GO:0070857)3.07718519
72regulation of mast cell degranulation (GO:0043304)3.04883894
73exogenous drug catabolic process (GO:0042738)3.03236688
74regulation of myeloid leukocyte mediated immunity (GO:0002886)3.02942816
75positive regulation of interferon-alpha production (GO:0032727)3.02629176
76angiotensin maturation (GO:0002003)3.01513847
77respiratory burst (GO:0045730)3.01155650
78regulation of dendritic cell antigen processing and presentation (GO:0002604)2.99873989
79positive regulation of leukocyte degranulation (GO:0043302)2.99337958
80positive regulation of guanylate cyclase activity (GO:0031284)2.98844000
81lipoxygenase pathway (GO:0019372)2.98337127
82T cell lineage commitment (GO:0002360)2.97493625
83intestinal absorption (GO:0050892)2.97263389
84regulation of antigen processing and presentation (GO:0002577)2.94572854
85pyrimidine ribonucleoside catabolic process (GO:0046133)2.91752552
86B cell mediated immunity (GO:0019724)2.91017942
87regulation of cholesterol homeostasis (GO:2000188)2.90942212
88regulation of mast cell activation involved in immune response (GO:0033006)2.90271425
89killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.88906589
90disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.88906589
91regulation of interferon-alpha production (GO:0032647)2.88568106
92hepatocyte differentiation (GO:0070365)2.87339109
93cellular response to exogenous dsRNA (GO:0071360)2.87169653
94mRNA modification (GO:0016556)2.86997526
95N-acetylneuraminate metabolic process (GO:0006054)2.85721842
96NADH metabolic process (GO:0006734)2.85336607
97leukotriene biosynthetic process (GO:0019370)2.84899354
98regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.84398090
99NIK/NF-kappaB signaling (GO:0038061)2.84241187
100positive regulation of gamma-delta T cell activation (GO:0046645)2.84094819
101pyrimidine-containing compound transmembrane transport (GO:0072531)2.82557212
102interferon-gamma-mediated signaling pathway (GO:0060333)2.82275367
103keratinization (GO:0031424)2.80797034
104regulation of leukocyte degranulation (GO:0043300)2.78548077
105defense response to protozoan (GO:0042832)2.77836294
106ectoderm development (GO:0007398)2.77510582
107germinal center formation (GO:0002467)2.77153725
108negative regulation of calcium ion transport into cytosol (GO:0010523)2.75182690
109intestinal cholesterol absorption (GO:0030299)2.75181337
110regulation of mast cell activation (GO:0033003)2.74370550
111fat-soluble vitamin biosynthetic process (GO:0042362)2.73760064
112wound healing, spreading of epidermal cells (GO:0035313)2.73380986
113water homeostasis (GO:0030104)2.72637671
114drug catabolic process (GO:0042737)2.72376996
115regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.72103162
116epoxygenase P450 pathway (GO:0019373)2.71861134
117T cell selection (GO:0045058)2.70951594
118positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.69717102
119hepatocyte apoptotic process (GO:0097284)2.69378082
120negative regulation of keratinocyte proliferation (GO:0010839)2.66273053
121regulation of interleukin-8 secretion (GO:2000482)2.65919416
122cellular glucuronidation (GO:0052695)2.65730884
123positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.64568602
124negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.64088729
125sulfate transport (GO:0008272)2.62948223
126daunorubicin metabolic process (GO:0044597)2.62787718
127polyketide metabolic process (GO:0030638)2.62787718
128doxorubicin metabolic process (GO:0044598)2.62787718
129innate immune response in mucosa (GO:0002227)2.60285799
130interferon-gamma secretion (GO:0072643)2.60156613
131growth hormone receptor signaling pathway (GO:0060396)2.57986419
132regulation of type I interferon-mediated signaling pathway (GO:0060338)2.57915263
133negative thymic T cell selection (GO:0045060)2.57046389
134regulation of p38MAPK cascade (GO:1900744)2.56622315
135response to host (GO:0075136)2.56569492
136response to host defenses (GO:0052200)2.56569492
137response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.56569492
138regulation of B cell differentiation (GO:0045577)2.55915470
139disruption of cells of other organism (GO:0044364)2.55472559
140killing of cells of other organism (GO:0031640)2.55472559
141defense response to Gram-positive bacterium (GO:0050830)2.54346517
142establishment of endothelial barrier (GO:0061028)2.52751346
143morphogenesis of an endothelium (GO:0003159)2.51617511
144endothelial tube morphogenesis (GO:0061154)2.51617511
145positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.51348984
146T cell migration (GO:0072678)2.50704989
147adhesion of symbiont to host (GO:0044406)2.50538171
148glucuronate metabolic process (GO:0019585)2.50343274
149uronic acid metabolic process (GO:0006063)2.50343274
150phagosome maturation (GO:0090382)2.49385381
151negative regulation of mast cell activation (GO:0033004)2.49261233
152branching involved in labyrinthine layer morphogenesis (GO:0060670)2.48098972
153response to host immune response (GO:0052572)2.48081288
154response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.48081288
155regulation of regulated secretory pathway (GO:1903305)2.47597063
156regulation of gamma-delta T cell activation (GO:0046643)2.47090531
157positive regulation of regulated secretory pathway (GO:1903307)2.46731360
158positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.46416790
159regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.46416790
160regulation of B cell proliferation (GO:0030888)2.46307878
161epidermal cell differentiation (GO:0009913)2.43855975
162tachykinin receptor signaling pathway (GO:0007217)2.42900005
163somatic diversification of immune receptors via somatic mutation (GO:0002566)2.42787975
164somatic hypermutation of immunoglobulin genes (GO:0016446)2.42787975
165positive regulation of antigen processing and presentation (GO:0002579)2.42198061
166negative regulation of cell killing (GO:0031342)2.42000238
167negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.42000238
168neutrophil chemotaxis (GO:0030593)2.40937605
169hypotonic response (GO:0006971)2.40340587
170phospholipid efflux (GO:0033700)2.39850535
171vitamin A metabolic process (GO:0006776)2.38855156
172positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.38393128
173response to protozoan (GO:0001562)2.38121229
174drug metabolic process (GO:0017144)2.37945893
175antigen receptor-mediated signaling pathway (GO:0050851)2.36682246
176negative T cell selection (GO:0043383)2.36242887
177positive T cell selection (GO:0043368)2.36140017
178positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.35192595
179rRNA catabolic process (GO:0016075)2.35095068
180positive regulation of DNA-templated transcription, initiation (GO:2000144)2.34567058
181positive regulation of B cell proliferation (GO:0030890)2.34066991
182cellular response to virus (GO:0098586)2.32309817
183lipoprotein transport (GO:0042953)2.30752121
184peptide catabolic process (GO:0043171)2.30117184
185activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.26992707
186transcription from mitochondrial promoter (GO:0006390)2.26919618
187basic amino acid transport (GO:0015802)2.26549433
188negative regulation of histone methylation (GO:0031061)2.26386211
189drug transmembrane transport (GO:0006855)2.26117629
190regulation of gamma-delta T cell differentiation (GO:0045586)2.24155115
191regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.23511855
192regulation of interferon-beta production (GO:0032648)2.23463244
193G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.21863305

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.88414529
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.69020805
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.75399626
4MYC_22102868_ChIP-Seq_BL_Human3.67275181
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.91445432
6E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.89504339
7E2F7_22180533_ChIP-Seq_HELA_Human2.88767749
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.85008364
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.81437920
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.75352490
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.45286330
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39068190
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.24081476
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.12375421
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.11992028
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.10676435
17CIITA_25753668_ChIP-Seq_RAJI_Human2.04874625
18MYB_26560356_Chip-Seq_TH2_Human2.04475906
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97554155
20MYB_26560356_Chip-Seq_TH1_Human1.94100163
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.93657056
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.87752233
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.76314289
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75845165
25AHR_22903824_ChIP-Seq_MCF-7_Human1.73632397
26SOX2_20726797_ChIP-Seq_SW620_Human1.71610850
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70160451
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69745399
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68921791
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.65630428
31KLF5_25053715_ChIP-Seq_YYC3_Human1.65426772
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65362312
33GATA1_22025678_ChIP-Seq_K562_Human1.64971479
34P63_26484246_Chip-Seq_KERATINOCYTES_Human1.64770950
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64629975
36HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.63918367
37RXR_22108803_ChIP-Seq_LS180_Human1.58993205
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.56888283
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.56507957
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.55807647
41MAF_26560356_Chip-Seq_TH1_Human1.55207944
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.53163088
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53069379
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.52605092
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.52417637
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48929886
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.48533083
48GATA4_25053715_ChIP-Seq_YYC3_Human1.47398458
49TCF4_18268006_ChIP-ChIP_LS174T_Human1.46553108
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.46060661
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44591724
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.39880920
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.39359553
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38882217
55FOXP3_21729870_ChIP-Seq_TREG_Human1.38641078
56LXR_22158963_ChIP-Seq_LIVER_Mouse1.38531351
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38214059
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36254819
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35971640
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.35520185
61BCOR_27268052_Chip-Seq_Bcells_Human1.35072112
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34964833
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34651185
64KDM5A_27292631_Chip-Seq_BREAST_Human1.34342071
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33688220
66SPI1_23547873_ChIP-Seq_NB4_Human1.33510204
67SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.32990401
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31956531
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31956531
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.31923608
71MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31831613
72GATA3_27048872_Chip-Seq_THYMUS_Human1.26172007
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24304843
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22805838
75VDR_23849224_ChIP-Seq_CD4+_Human1.22755102
76P300_27268052_Chip-Seq_Bcells_Human1.22164725
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20688455
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16284291
79GATA3_26560356_Chip-Seq_TH2_Human1.14598573
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14585108
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13720104
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12632440
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12332767
84UTX_26944678_Chip-Seq_JUKART_Human1.11081357
85MAF_26560356_Chip-Seq_TH2_Human1.08103452
86TP63_23658742_ChIP-Seq_EP156T_Human1.07282146
87IRF8_27001747_Chip-Seq_BMDM_Mouse1.06423178
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05887940
89E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04059825
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03982385
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03812656
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.03786140
93CJUN_26792858_Chip-Seq_BT549_Human1.03343656
94P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03321999
95GATA6_25053715_ChIP-Seq_YYC3_Human1.02874318
96TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01336287
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01065883
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00682775
99IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99810783
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99560154
101VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98523587
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98001254
103JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97997590
104NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97761444
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97316281
106RUNX_20019798_ChIP-Seq_JUKART_Human0.97177420
107FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97111436
108VDR_22108803_ChIP-Seq_LS180_Human0.96461305
109GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95535093
110FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95496916
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95321624
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94697696
113HNF4A_19822575_ChIP-Seq_HepG2_Human0.93653297
114VDR_21846776_ChIP-Seq_THP-1_Human0.93422517
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93028241
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.92786448
117BCL6_27268052_Chip-Seq_Bcells_Human0.92526987
118KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.91844656
119ELF1_20517297_ChIP-Seq_JURKAT_Human0.91818925
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91126425
121IRF1_19129219_ChIP-ChIP_H3396_Human0.90765413
122RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90694580
123TP53_18474530_ChIP-ChIP_U2OS_Human0.90114271
124PHF8_20622854_ChIP-Seq_HELA_Human0.89932743
125GATA2_19941826_ChIP-Seq_K562_Human0.89821786
126SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89523121
127RACK7_27058665_Chip-Seq_MCF-7_Human0.89169152
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89140990
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88702888
130NANOG_20526341_ChIP-Seq_ESCs_Human0.88511940
131TFEB_21752829_ChIP-Seq_HELA_Human0.88363321
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88133514
133E2F1_20622854_ChIP-Seq_HELA_Human0.88039216
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87950360
135BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86743324
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86713452
137FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.85933691
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85675411
139CEBPB_22108803_ChIP-Seq_LS180_Human0.85515287
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85446519
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84875904
142GABP_19822575_ChIP-Seq_HepG2_Human0.84275522
143PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84033087
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83810618
145POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83624236
146RUNX1_22412390_ChIP-Seq_EML_Mouse0.83600414
147KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83515417
148CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83324538
149SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82694928
150PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82595335
151STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.82466344
152HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82465421
153NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.82285854
154GATA3_24758297_ChIP-Seq_MCF-7_Human0.81988325
155VDR_24787735_ChIP-Seq_THP-1_Human0.81557974
156GBX2_23144817_ChIP-Seq_PC3_Human0.81054878
157JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80192089
158TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80059991
159ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79353779
160PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79174586
161KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77270864
162KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.77270864
163KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77270864
164TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75647302
165CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.74742471
166LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73336811
167BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71933181
168NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.71743530
169LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.71052870
170CDX2_22108803_ChIP-Seq_LS180_Human0.71039587
171ISL1_27105846_Chip-Seq_CPCs_Mouse0.70081030
172SMAD3_21741376_ChIP-Seq_EPCs_Human0.68809909
173RNF2_27304074_Chip-Seq_NSC_Mouse0.68388074
174EGR1_19032775_ChIP-ChIP_M12_Human0.67874646
175DROSHA_22980978_ChIP-Seq_HELA_Human0.67618073
176FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67241677
177SUZ12_27294783_Chip-Seq_NPCs_Mouse0.67144186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.98113572
2MP0003183_abnormal_peptide_metabolism3.98001954
3MP0002277_abnormal_respiratory_mucosa3.97075374
4MP0002139_abnormal_hepatobiliary_system3.92316697
5MP0002796_impaired_skin_barrier3.50781849
6MP0005360_urolithiasis3.39199044
7MP0002138_abnormal_hepatobiliary_system3.36481135
8MP0009278_abnormal_bone_marrow3.18115070
9MP0003453_abnormal_keratinocyte_physiol3.05324965
10MP0000566_synostosis2.98821566
11MP0003941_abnormal_skin_development2.77591547
12MP0001835_abnormal_antigen_presentation2.75701448
13MP0004264_abnormal_extraembryonic_tissu2.73346755
14MP0008004_abnormal_stomach_pH2.71446655
15MP0003195_calcinosis2.63843461
16MP0004782_abnormal_surfactant_physiolog2.45299912
17MP0010678_abnormal_skin_adnexa2.44654207
18MP0005085_abnormal_gallbladder_physiolo2.44025643
19MP0002098_abnormal_vibrissa_morphology2.36400330
20MP0005501_abnormal_skin_physiology2.32463387
21MP0002254_reproductive_system_inflammat2.25999551
22MP0005671_abnormal_response_to2.21132492
23MP0000383_abnormal_hair_follicle2.19546451
24MP0003136_yellow_coat_color2.14849835
25MP0001216_abnormal_epidermal_layer2.14743212
26MP0001346_abnormal_lacrimal_gland2.13966882
27MP0005365_abnormal_bile_salt2.08436833
28MP0003693_abnormal_embryo_hatching2.06764099
29MP0009785_altered_susceptibility_to2.05218571
30MP0008057_abnormal_DNA_replication2.02250689
31MP0003436_decreased_susceptibility_to2.01090424
32MP0002060_abnormal_skin_morphology1.96099046
33MP0003566_abnormal_cell_adhesion1.95281299
34MP0003763_abnormal_thymus_physiology1.91275083
35MP0009333_abnormal_splenocyte_physiolog1.91272637
36MP0003646_muscle_fatigue1.86729709
37MP0002723_abnormal_immune_serum1.86107154
38MP0004381_abnormal_hair_follicle1.83770299
39MP0000427_abnormal_hair_cycle1.76922319
40MP0009840_abnormal_foam_cell1.75816522
41MP0001666_abnormal_nutrient_absorption1.70295419
42MP0002653_abnormal_ependyma_morphology1.66505506
43MP0002166_altered_tumor_susceptibility1.66473135
44MP0002837_dystrophic_cardiac_calcinosis1.64847398
45MP0004947_skin_inflammation1.64453842
46MP0003252_abnormal_bile_duct1.60695140
47MP0010771_integument_phenotype1.60642290
48MP0002132_abnormal_respiratory_system1.60446654
49MP0002163_abnormal_gland_morphology1.57198038
50MP0000579_abnormal_nail_morphology1.53431996
51MP0001664_abnormal_digestion1.53338947
52MP0001873_stomach_inflammation1.51970484
53MP0000716_abnormal_immune_system1.43099419
54MP0010352_gastrointestinal_tract_polyps1.41551669
55MP0003724_increased_susceptibility_to1.40264155
56MP0005310_abnormal_salivary_gland1.39097449
57MP0000689_abnormal_spleen_morphology1.39003277
58MP0005332_abnormal_amino_acid1.38660556
59MP0000516_abnormal_urinary_system1.38321642
60MP0005367_renal/urinary_system_phenotyp1.38321642
61MP0002398_abnormal_bone_marrow1.37728080
62MP0005248_abnormal_Harderian_gland1.36315962
63MP0008875_abnormal_xenobiotic_pharmacok1.35570842
64MP0000762_abnormal_tongue_morphology1.33423688
65MP0005377_hearing/vestibular/ear_phenot1.32962206
66MP0003878_abnormal_ear_physiology1.32962206
67MP0002419_abnormal_innate_immunity1.32935217
68MP0005171_absent_coat_pigmentation1.32589418
69MP0003806_abnormal_nucleotide_metabolis1.31743302
70MP0003950_abnormal_plasma_membrane1.30642739
71MP0010094_abnormal_chromosome_stability1.30383466
72MP0002006_tumorigenesis1.29682764
73MP0005387_immune_system_phenotype1.23920627
74MP0001790_abnormal_immune_system1.23920627
75MP0010329_abnormal_lipoprotein_level1.21731327
76MP0003111_abnormal_nucleus_morphology1.21288914
77MP0005167_abnormal_blood-brain_barrier1.20197867
78MP0005451_abnormal_body_composition1.20026653
79MP0005275_abnormal_skin_tensile1.19964653
80MP0001764_abnormal_homeostasis1.19878871
81MP0009764_decreased_sensitivity_to1.18676454
82MP0004043_abnormal_pH_regulation1.16531818
83MP0002429_abnormal_blood_cell1.16460305
84MP0000467_abnormal_esophagus_morphology1.14781340
85MP0002148_abnormal_hypersensitivity_rea1.11885294
86MP0008789_abnormal_olfactory_epithelium1.11418225
87MP0000685_abnormal_immune_system1.11341089
88MP0000470_abnormal_stomach_morphology1.11117693
89MP0004957_abnormal_blastocyst_morpholog1.10691696
90MP0005379_endocrine/exocrine_gland_phen1.09171348
91MP0005025_abnormal_response_to1.08920224
92MP0000609_abnormal_liver_physiology1.08102290
93MP0001191_abnormal_skin_condition1.06864968
94MP0002722_abnormal_immune_system1.06845853
95MP0010155_abnormal_intestine_physiology1.06627896
96MP0002396_abnormal_hematopoietic_system1.06326952
97MP0000490_abnormal_crypts_of1.04585915
98MP0009643_abnormal_urine_homeostasis1.04555620
99MP0005164_abnormal_response_to1.04075806
100MP0003303_peritoneal_inflammation1.03435510
101MP0004019_abnormal_vitamin_homeostasis1.03364552
102MP0001533_abnormal_skeleton_physiology1.03256775
103MP0000678_abnormal_parathyroid_gland1.02281171
104MP0000377_abnormal_hair_follicle1.00221444
105MP0002009_preneoplasia0.99462395
106MP0002136_abnormal_kidney_physiology0.98893235
107MP0000462_abnormal_digestive_system0.97452109
108MP0004883_abnormal_blood_vessel0.96634601
109MP0001661_extended_life_span0.96343929
110MP0002876_abnormal_thyroid_physiology0.95996340
111MP0001881_abnormal_mammary_gland0.94551111
112MP0000465_gastrointestinal_hemorrhage0.94297402
113MP0003879_abnormal_hair_cell0.93995042
114MP0003866_abnormal_defecation0.93919256
115MP0009931_abnormal_skin_appearance0.93602717
116MP0002693_abnormal_pancreas_physiology0.93480675
117MP0008469_abnormal_protein_level0.92175920
118MP0002933_joint_inflammation0.92050069
119MP0001663_abnormal_digestive_system0.90510969
120MP0002452_abnormal_antigen_presenting0.90169651
121MP0002405_respiratory_system_inflammati0.88654700
122MP0001853_heart_inflammation0.88556269
123MP0003300_gastrointestinal_ulcer0.84880974
124MP0003077_abnormal_cell_cycle0.84879787
125MP0005381_digestive/alimentary_phenotyp0.84803659
126MP0001800_abnormal_humoral_immune0.84733894
127MP0001819_abnormal_immune_cell0.83752625
128MP0002420_abnormal_adaptive_immunity0.81347138
129MP0000703_abnormal_thymus_morphology0.81174940
130MP0000858_altered_metastatic_potential0.81159427
131MP0001958_emphysema0.81131313
132MP0005645_abnormal_hypothalamus_physiol0.80501939
133MP0005166_decreased_susceptibility_to0.80023061
134MP0001845_abnormal_inflammatory_respons0.79665096
135MP0005084_abnormal_gallbladder_morpholo0.79112186
136MP0001485_abnormal_pinna_reflex0.78902836
137MP0005397_hematopoietic_system_phenotyp0.78622622
138MP0001545_abnormal_hematopoietic_system0.78622622
139MP0001765_abnormal_ion_homeostasis0.77187667
140MP0000627_abnormal_mammary_gland0.76709165
141MP0003075_altered_response_to0.76242070
142MP0001984_abnormal_olfaction0.75894591
143MP0005023_abnormal_wound_healing0.74076818
144MP0001986_abnormal_taste_sensitivity0.73655249
145MP0003786_premature_aging0.73452010
146MP0006292_abnormal_olfactory_placode0.73144716
147MP0000477_abnormal_intestine_morphology0.72823561
148MP0005499_abnormal_olfactory_system0.72554465
149MP0005394_taste/olfaction_phenotype0.72554465
150MP0001730_embryonic_growth_arrest0.70306194
151MP0006035_abnormal_mitochondrial_morpho0.69548377
152MP0003191_abnormal_cellular_cholesterol0.69242553
153MP0005000_abnormal_immune_tolerance0.69216163
154MP0002019_abnormal_tumor_incidence0.67775402
155MP0003172_abnormal_lysosome_physiology0.65117893
156MP0002118_abnormal_lipid_homeostasis0.64555054
157MP0008877_abnormal_DNA_methylation0.64396685
158MP0005075_abnormal_melanosome_morpholog0.63815595
159MP0003045_fibrosis0.61875536

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.82873193
2Eczematoid dermatitis (HP:0000976)5.28566957
3Onycholysis (HP:0001806)4.74338058
4Spontaneous hematomas (HP:0007420)4.64825659
5Agammaglobulinemia (HP:0004432)4.63220481
6Recurrent abscess formation (HP:0002722)3.96558523
7Parakeratosis (HP:0001036)3.94153259
8Plantar hyperkeratosis (HP:0007556)3.90871354
9Gastrointestinal stroma tumor (HP:0100723)3.69289957
10Pustule (HP:0200039)3.58216597
11Recurrent sinusitis (HP:0011108)3.57810169
12Lip pit (HP:0100267)3.56893100
13Milia (HP:0001056)3.50140531
14IgM deficiency (HP:0002850)3.45242415
15Recurrent bacterial skin infections (HP:0005406)3.42585939
16Increased IgE level (HP:0003212)3.35552231
17Colitis (HP:0002583)3.30286810
18Aplasia cutis congenita (HP:0001057)3.28714285
19Chronic diarrhea (HP:0002028)3.21378431
20Corneal erosion (HP:0200020)3.11495151
21Hematochezia (HP:0002573)3.09982254
22Recurrent corneal erosions (HP:0000495)3.07838158
23Cheilitis (HP:0100825)3.05020663
24Dehydration (HP:0001944)3.01876105
25Palmar hyperkeratosis (HP:0010765)3.01838182
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.00413000
27Hyperactive renin-angiotensin system (HP:0000841)3.00323443
28Abnormality of glutamine family amino acid metabolism (HP:0010902)2.96849222
29Chronic bronchitis (HP:0004469)2.96723450
30Ectropion (HP:0000656)2.95390170
31Palmoplantar hyperkeratosis (HP:0000972)2.92077139
32Gingivitis (HP:0000230)2.89258757
33Ventricular tachycardia (HP:0004756)2.88524791
34Recurrent gram-negative bacterial infections (HP:0005420)2.83630183
35Curly hair (HP:0002212)2.83583288
36Urticaria (HP:0001025)2.82876984
37Recurrent viral infections (HP:0004429)2.81193436
38Panhypogammaglobulinemia (HP:0003139)2.79692020
39Interstitial pulmonary disease (HP:0006530)2.79224906
40Obstructive lung disease (HP:0006536)2.77330932
41Chronic obstructive pulmonary disease (HP:0006510)2.77330932
42Recurrent bronchitis (HP:0002837)2.71624004
43Papilloma (HP:0012740)2.68793852
44Verrucae (HP:0200043)2.68793852
45Fragile nails (HP:0001808)2.68751688
46Lymphopenia (HP:0001888)2.67804089
47Abnormality of macrophages (HP:0004311)2.63139472
48Gastrointestinal inflammation (HP:0004386)2.62725870
49Absent eyebrow (HP:0002223)2.62046494
50Congenital ichthyosiform erythroderma (HP:0007431)2.61905653
51IgA deficiency (HP:0002720)2.61735014
52Vasculitis (HP:0002633)2.59950429
53Alopecia of scalp (HP:0002293)2.58373109
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.57299564
55Atrophic scars (HP:0001075)2.56183670
56Abnormality of chloride homeostasis (HP:0011422)2.55866664
57Abnormality of T cell physiology (HP:0011840)2.54100549
58Malnutrition (HP:0004395)2.53853621
59Hyperglycinuria (HP:0003108)2.53824919
60Decreased circulating renin level (HP:0003351)2.53346291
61Pili torti (HP:0003777)2.51114946
62Woolly hair (HP:0002224)2.48449814
63Hypobetalipoproteinemia (HP:0003563)2.44391016
64Autoimmune thrombocytopenia (HP:0001973)2.43991360
65Sepsis (HP:0100806)2.42659578
66Hypoplasia of dental enamel (HP:0006297)2.39535328
67Amelogenesis imperfecta (HP:0000705)2.37935842
68Recurrent fungal infections (HP:0002841)2.32820462
69Hypotrichosis (HP:0001006)2.30379552
70Hypoplastic labia majora (HP:0000059)2.29469579
71Hypohidrosis (HP:0000966)2.28319749
72Portal hypertension (HP:0001409)2.27646531
73Premature loss of primary teeth (HP:0006323)2.27549835
74Viral hepatitis (HP:0006562)2.27003256
75Abnormality of small intestinal villus morphology (HP:0011472)2.24669705
76Villous atrophy (HP:0011473)2.24669705
77Bronchitis (HP:0012387)2.23354530
78Absent/shortened dynein arms (HP:0200106)2.22994082
79Dynein arm defect of respiratory motile cilia (HP:0012255)2.22994082
80Homocystinuria (HP:0002156)2.22892692
81Abnormality of homocysteine metabolism (HP:0010919)2.22892692
82Abnormality of monocarboxylic acid metabolism (HP:0010996)2.22444122
83Hyperphosphatemia (HP:0002905)2.21530895
84Abnormality of the hepatic vasculature (HP:0006707)2.21426593
85Mediastinal lymphadenopathy (HP:0100721)2.21026734
86Gastrointestinal infarctions (HP:0005244)2.17843138
87Chronic otitis media (HP:0000389)2.17226470
88Nail dystrophy (HP:0008404)2.16277090
89Conjugated hyperbilirubinemia (HP:0002908)2.14849516
90IgG deficiency (HP:0004315)2.12604919
91Recurrent pneumonia (HP:0006532)2.10113777
92Emphysema (HP:0002097)2.09260352
93Vascular calcification (HP:0004934)2.08567472
94Symptomatic seizures (HP:0011145)2.08238492
95Abnormality of the vitamin B12 metabolism (HP:0004341)2.08125047
96Abnormality of the gastric mucosa (HP:0004295)2.07448036
97Abnormality of proline metabolism (HP:0010907)2.05904658
98Hydroxyprolinuria (HP:0003080)2.05904658
99Progressive sensorineural hearing impairment (HP:0000408)2.05563155
100Generalized aminoaciduria (HP:0002909)2.04477696
101Cellulitis (HP:0100658)2.04431754
102Abnormality of T cells (HP:0002843)2.03847323
103Recurrent cutaneous fungal infections (HP:0011370)2.03591750
104Chronic mucocutaneous candidiasis (HP:0002728)2.03591750
105Abnormality of vitamin B metabolism (HP:0004340)2.03247430
106Late onset (HP:0003584)2.02493131
107Abnormality of glycine metabolism (HP:0010895)1.99606114
108Abnormality of serine family amino acid metabolism (HP:0010894)1.99606114
109Hyponatremia (HP:0002902)1.98683356
110Abnormality of the prostate (HP:0008775)1.97746077
111Septate vagina (HP:0001153)1.96171576
112Abnormality of the labia majora (HP:0012881)1.95118758
113Erythroderma (HP:0001019)1.94434066
114Blepharitis (HP:0000498)1.93529012
115Abnormal blistering of the skin (HP:0008066)1.93253517
116Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.92507266
117Widely patent fontanelles and sutures (HP:0004492)1.91712342
118Short femoral neck (HP:0100864)1.90817974
119Skin ulcer (HP:0200042)1.90303951
120Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89967007
121Abnormal biliary tract physiology (HP:0012439)1.89053102
122Bile duct proliferation (HP:0001408)1.89053102
123Recurrent skin infections (HP:0001581)1.88858592
124Inflammation of the large intestine (HP:0002037)1.88400540
125Progressive hearing impairment (HP:0001730)1.88079486
126Abnormal tarsal ossification (HP:0008369)1.87685868
127Ureteral duplication (HP:0000073)1.87572226
128Myositis (HP:0100614)1.87087363
129Congenital sensorineural hearing impairment (HP:0008527)1.87024737
130Abnormal respiratory motile cilium physiology (HP:0012261)1.86690692
131Posterior subcapsular cataract (HP:0007787)1.86317062
132Abnormal delayed hypersensitivity skin test (HP:0002963)1.84732858
133Osteomyelitis (HP:0002754)1.84008360
134Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83913983
135Abnormality of sulfur amino acid metabolism (HP:0004339)1.83611732
136Dry hair (HP:0011359)1.83578382
137Abnormal hair laboratory examination (HP:0003328)1.83307217
138Lymphoma (HP:0002665)1.82357558
139Progressive external ophthalmoplegia (HP:0000590)1.81269537
140Abnormal pancreas size (HP:0012094)1.81133614
141Abnormality of the renal collecting system (HP:0004742)1.79809921
142Restrictive lung disease (HP:0002091)1.78755006
143Ureteral stenosis (HP:0000071)1.78564903
144Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77041085
145Abnormal ciliary motility (HP:0012262)1.75759741
146Hypoglycemic coma (HP:0001325)1.75527181
147Abnormality of the nasal mucosa (HP:0000433)1.74887424
148Hypochromic anemia (HP:0001931)1.74835219
149Stomatitis (HP:0010280)1.74436727
150Lower limb hyperreflexia (HP:0002395)1.74370171
151White forelock (HP:0002211)1.74006578
152Skin rash (HP:0000988)1.73850174
153Microcytic anemia (HP:0001935)1.73762784
154Conical tooth (HP:0000698)1.73559671
155Recurrent otitis media (HP:0000403)1.72060790
156Hyperkalemia (HP:0002153)1.71982016
157Intrahepatic cholestasis (HP:0001406)1.71220036
158Abnormality of renin-angiotensin system (HP:0000847)1.71033289
159Alkalosis (HP:0001948)1.70824140
160Duplicated collecting system (HP:0000081)1.70310163
161Impulsivity (HP:0100710)1.69789867
162Cardiovascular calcification (HP:0011915)1.69205736
163Xerostomia (HP:0000217)1.69008839
164Encephalitis (HP:0002383)1.68952229
165Oligodontia (HP:0000677)1.67585133
166Abnormality of vitamin metabolism (HP:0100508)1.67172438
167Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66961955
168Esophageal varix (HP:0002040)1.66800801
169Popliteal pterygium (HP:0009756)1.65974714
170Abnormality of endocrine pancreas physiology (HP:0012093)1.65916042
171Anhidrosis (HP:0000970)1.65570746
172Meningitis (HP:0001287)1.65000909
173Hypophosphatemic rickets (HP:0004912)1.64972340
174Vacuolated lymphocytes (HP:0001922)1.64878539
175Abnormality of the right ventricle (HP:0001707)1.64186733
176Natal tooth (HP:0000695)1.64113382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.73612045
2MAP3K104.63156715
3EPHA24.37099105
4MST43.99086425
5BLK3.84416028
6SMG13.21722935
7EPHB12.98421133
8PRPF4B2.98215527
9FGR2.92500742
10FRK2.88298568
11AKT32.73295081
12ACVR1B2.69291875
13RIPK12.62366733
14CSK2.62123105
15IRAK42.42098132
16MAP3K132.40492954
17TRPM72.28712705
18CASK2.26186873
19EEF2K2.25544629
20ERN12.12035678
21STK101.96452816
22TAOK31.81490755
23YES11.81294389
24PTK21.80023041
25TAF11.79469232
26EIF2AK31.73726658
27BCR1.68837835
28LATS11.67951746
29MAP3K141.63780895
30TYK21.62199633
31PRKG21.61754289
32MST1R1.56386250
33MAP3K91.54773373
34MAP3K121.52723297
35TEC1.50549122
36SIK31.49343174
37CSF1R1.49225844
38ERBB31.48916211
39TLK11.39806226
40ZAK1.38997253
41IKBKB1.38380123
42IKBKE1.37383057
43PASK1.28847965
44BTK1.28430359
45STK241.26821811
46PTK61.22880397
47GRK61.21239229
48FER1.21236313
49CDK91.14241751
50SYK1.11522754
51CDK121.07378909
52FGFR41.05402394
53EPHA31.02749130
54MAP2K21.02606147
55STK391.02516072
56ITK1.01585695
57CHUK1.01207568
58NUAK11.00753186
59TBK10.99343699
60MATK0.98234387
61MAP2K60.98065943
62CDK40.97924025
63RIPK40.97495453
64PRKCI0.90226356
65MAPKAPK30.89324082
66FGFR30.88654800
67MAP3K70.87328150
68MAP3K30.87264237
69MET0.86952672
70NEK90.86398899
71MAPKAPK20.85238908
72JAK30.83899355
73STK38L0.82374305
74GRK10.82161509
75PIK3CA0.82103174
76ICK0.81269658
77PAK40.81175744
78TRIB30.80634620
79LMTK20.80090271
80BRSK20.75901491
81IRAK20.74605436
82LRRK20.71808736
83PDK10.70782420
84ADRBK20.70507448
85MAPK150.70271028
86BUB10.69345601
87SRPK10.68686388
88LYN0.68613229
89CDC42BPA0.67775503
90NLK0.66977672
91MAP3K80.66481676
92HIPK20.66361917
93CDK80.65387568
94JAK10.63725825
95VRK20.62317908
96SIK10.62308685
97TTK0.61740595
98STK110.61530642
99SIK20.57455419
100VRK10.55355261
101HCK0.54815676
102MAP3K110.53979246
103PDPK10.52983619
104MARK30.52571676
105CSNK1A1L0.52558514
106STK30.52396336
107WNK40.50383552
108DMPK0.48843748
109MELK0.48478714
110BRAF0.48446092
111RPS6KB10.45813591
112WNK10.45484698
113TGFBR20.45417954
114PIM20.45249583
115TTN0.44773452
116IRAK30.44647999
117RPS6KB20.43300975
118PINK10.40869402
119CDC70.39377205
120MYLK0.39352566
121FYN0.38826519
122MAP3K10.38102973
123PRKCQ0.37935079
124BMPR20.37901092
125MAPK70.37830073
126ATR0.37238271
127MAP3K20.36838104
128CHEK10.36568899
129EIF2AK20.36409008
130SGK30.36274099
131LCK0.35706869
132CAMK1D0.35436338
133IRAK10.35194718
134TNK20.34288424
135DAPK20.33591608
136ROCK20.33516418
137RPS6KA20.33436654
138GRK70.33060900
139EPHB20.32648247
140PRKCE0.30311986
141FGFR10.28516536
142INSR0.28379963
143ABL10.26972362
144BMX0.26784276
145ADRBK10.26711244
146RPS6KA10.25914040
147GSK3A0.25906825
148PIM10.25901853
149PRKAA20.25543213
150MAPK110.25461583
151EGFR0.25053355
152MAPK120.25012387
153SRC0.24550228
154OXSR10.24197545

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.49589003
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.25316437
3Type I diabetes mellitus_Homo sapiens_hsa049402.82840529
4Primary immunodeficiency_Homo sapiens_hsa053402.64815064
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.60473101
6Mineral absorption_Homo sapiens_hsa049782.48175596
7Leukocyte transendothelial migration_Homo sapiens_hsa046702.24886449
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.10863910
9Fat digestion and absorption_Homo sapiens_hsa049751.99647987
10Histidine metabolism_Homo sapiens_hsa003401.98398377
11Vitamin digestion and absorption_Homo sapiens_hsa049771.89122629
12Leishmaniasis_Homo sapiens_hsa051401.88698633
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88152384
14Antigen processing and presentation_Homo sapiens_hsa046121.85496867
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.72994066
16Sphingolipid metabolism_Homo sapiens_hsa006001.72342549
17Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.70909152
18Adherens junction_Homo sapiens_hsa045201.70576074
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.65524077
20Herpes simplex infection_Homo sapiens_hsa051681.57671737
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.56654893
22Bladder cancer_Homo sapiens_hsa052191.54385552
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53721528
24Staphylococcus aureus infection_Homo sapiens_hsa051501.39482905
25One carbon pool by folate_Homo sapiens_hsa006701.38220740
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.37228327
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36778756
28Arachidonic acid metabolism_Homo sapiens_hsa005901.34105873
29Hematopoietic cell lineage_Homo sapiens_hsa046401.30873977
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29167786
31Renin-angiotensin system_Homo sapiens_hsa046141.26823322
32Systemic lupus erythematosus_Homo sapiens_hsa053221.26731686
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26326273
34Olfactory transduction_Homo sapiens_hsa047401.26028570
35Shigellosis_Homo sapiens_hsa051311.25184736
36Tight junction_Homo sapiens_hsa045301.21362360
37Toxoplasmosis_Homo sapiens_hsa051451.14192256
38TNF signaling pathway_Homo sapiens_hsa046681.13733109
39Retinol metabolism_Homo sapiens_hsa008301.13715769
40Chemokine signaling pathway_Homo sapiens_hsa040621.13653736
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09368526
42Salmonella infection_Homo sapiens_hsa051321.06916221
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06384890
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04282800
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03355743
46Arginine biosynthesis_Homo sapiens_hsa002201.03189741
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02727288
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02441518
49Pancreatic cancer_Homo sapiens_hsa052121.00489509
50Hepatitis C_Homo sapiens_hsa051601.00151505
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.99961816
52Caffeine metabolism_Homo sapiens_hsa002320.99174368
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.96231148
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.95147646
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94837034
56Tuberculosis_Homo sapiens_hsa051520.94645601
57Protein digestion and absorption_Homo sapiens_hsa049740.94412156
58Hippo signaling pathway_Homo sapiens_hsa043900.94123023
59Osteoclast differentiation_Homo sapiens_hsa043800.93717848
60Fatty acid degradation_Homo sapiens_hsa000710.93680185
61Ether lipid metabolism_Homo sapiens_hsa005650.93034587
62African trypanosomiasis_Homo sapiens_hsa051430.92908829
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92829336
64Other glycan degradation_Homo sapiens_hsa005110.92195576
65Taste transduction_Homo sapiens_hsa047420.89711604
66Small cell lung cancer_Homo sapiens_hsa052220.87866157
67Phagosome_Homo sapiens_hsa041450.87429960
68Pathways in cancer_Homo sapiens_hsa052000.86591957
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85590344
70Melanoma_Homo sapiens_hsa052180.85347573
71Measles_Homo sapiens_hsa051620.85116187
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84976498
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84948454
74Rheumatoid arthritis_Homo sapiens_hsa053230.84264756
75* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83394645
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83160777
77Selenocompound metabolism_Homo sapiens_hsa004500.82594961
78Pertussis_Homo sapiens_hsa051330.81431747
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80074302
80Vitamin B6 metabolism_Homo sapiens_hsa007500.80008540
81Tryptophan metabolism_Homo sapiens_hsa003800.79812681
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79429599
83Arginine and proline metabolism_Homo sapiens_hsa003300.78839218
84PPAR signaling pathway_Homo sapiens_hsa033200.78255041
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77665494
86Rap1 signaling pathway_Homo sapiens_hsa040150.77635433
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77024769
88Collecting duct acid secretion_Homo sapiens_hsa049660.76305478
89T cell receptor signaling pathway_Homo sapiens_hsa046600.75783868
90Sulfur relay system_Homo sapiens_hsa041220.75341566
91Apoptosis_Homo sapiens_hsa042100.73233556
92Graft-versus-host disease_Homo sapiens_hsa053320.73154635
93Linoleic acid metabolism_Homo sapiens_hsa005910.72356005
94ECM-receptor interaction_Homo sapiens_hsa045120.72299825
95Fructose and mannose metabolism_Homo sapiens_hsa000510.72285092
96Pancreatic secretion_Homo sapiens_hsa049720.71515175
97Proteoglycans in cancer_Homo sapiens_hsa052050.70540524
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70527910
99Axon guidance_Homo sapiens_hsa043600.69910135
100Amoebiasis_Homo sapiens_hsa051460.69674765
101Epstein-Barr virus infection_Homo sapiens_hsa051690.69517254
102Focal adhesion_Homo sapiens_hsa045100.69340000
103MicroRNAs in cancer_Homo sapiens_hsa052060.68920898
104Influenza A_Homo sapiens_hsa051640.68240768
105* Jak-STAT signaling pathway_Homo sapiens_hsa046300.67945400
106B cell receptor signaling pathway_Homo sapiens_hsa046620.67714071
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66396477
108Notch signaling pathway_Homo sapiens_hsa043300.66357765
109Asthma_Homo sapiens_hsa053100.65916894
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65248108
111Insulin resistance_Homo sapiens_hsa049310.64688425
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.64113933
113DNA replication_Homo sapiens_hsa030300.64074933
114Butanoate metabolism_Homo sapiens_hsa006500.63659714
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63172526
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60403431
117Homologous recombination_Homo sapiens_hsa034400.60192175
118Non-homologous end-joining_Homo sapiens_hsa034500.59009328
119Legionellosis_Homo sapiens_hsa051340.57616339
120Phenylalanine metabolism_Homo sapiens_hsa003600.57079880
121Chemical carcinogenesis_Homo sapiens_hsa052040.56826941
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56610719
123Galactose metabolism_Homo sapiens_hsa000520.56258451
124Dorso-ventral axis formation_Homo sapiens_hsa043200.55827814
125Basal cell carcinoma_Homo sapiens_hsa052170.55673304
126Autoimmune thyroid disease_Homo sapiens_hsa053200.55456196
127Starch and sucrose metabolism_Homo sapiens_hsa005000.55430960
128VEGF signaling pathway_Homo sapiens_hsa043700.55381737
129Hepatitis B_Homo sapiens_hsa051610.54945522
130Inositol phosphate metabolism_Homo sapiens_hsa005620.54640042
131p53 signaling pathway_Homo sapiens_hsa041150.54175857
132ErbB signaling pathway_Homo sapiens_hsa040120.53913197
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.53830862
134Bile secretion_Homo sapiens_hsa049760.53745721
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53694584
136ABC transporters_Homo sapiens_hsa020100.52813535
137Peroxisome_Homo sapiens_hsa041460.52360618
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52328803
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.51954028
140RNA degradation_Homo sapiens_hsa030180.51879833
141Viral myocarditis_Homo sapiens_hsa054160.51719355
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51287342
143Vibrio cholerae infection_Homo sapiens_hsa051100.50829262
144Ras signaling pathway_Homo sapiens_hsa040140.50714331
145MAPK signaling pathway_Homo sapiens_hsa040100.50633016
146Acute myeloid leukemia_Homo sapiens_hsa052210.50542833
147Sulfur metabolism_Homo sapiens_hsa009200.50219672
148Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48185077
149Viral carcinogenesis_Homo sapiens_hsa052030.46850914
150Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46387047
151Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46374132
152Base excision repair_Homo sapiens_hsa034100.45163227
153Biosynthesis of amino acids_Homo sapiens_hsa012300.43261440
154Glycerolipid metabolism_Homo sapiens_hsa005610.42313572
155Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41874011
156Mismatch repair_Homo sapiens_hsa034300.38765839
157Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32868950

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