IFNW1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an interferon and possesses antiviral activity. The encoded protein binds to the interferon alpha/beta receptor but not to the interferon gamma receptor. This intronless gene has several pseudogenes spread throughout the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)6.83425953
2* regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)6.83425953
3* natural killer cell activation involved in immune response (GO:0002323)4.45602537
4* regulation of MHC class I biosynthetic process (GO:0045343)4.31468189
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.27315671
6detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.08366585
7retinal cone cell development (GO:0046549)3.97486372
8DNA integration (GO:0015074)3.97066800
9platelet dense granule organization (GO:0060155)3.96197341
10response to pheromone (GO:0019236)3.71439817
11nonmotile primary cilium assembly (GO:0035058)3.58690073
12cullin deneddylation (GO:0010388)3.58442205
13cellular response to exogenous dsRNA (GO:0071360)3.52981954
14cornea development in camera-type eye (GO:0061303)3.34019740
15neural tube formation (GO:0001841)3.33802504
16DNA double-strand break processing (GO:0000729)3.33162331
17photoreceptor cell maintenance (GO:0045494)3.31423111
18signal peptide processing (GO:0006465)3.30244350
19centriole replication (GO:0007099)3.25732736
20epithelial cilium movement (GO:0003351)3.21657727
21preassembly of GPI anchor in ER membrane (GO:0016254)3.20478523
22protein deneddylation (GO:0000338)3.20458008
23axoneme assembly (GO:0035082)3.16765082
24positive regulation of cAMP-mediated signaling (GO:0043950)3.12921673
25indolalkylamine metabolic process (GO:0006586)3.08037837
26glycosphingolipid biosynthetic process (GO:0006688)3.07707723
27protein K11-linked deubiquitination (GO:0035871)3.05316730
28L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.05060063
29intraciliary transport (GO:0042073)3.03891542
30adenosine metabolic process (GO:0046085)3.02669958
31ether lipid metabolic process (GO:0046485)2.98527825
32detection of light stimulus involved in visual perception (GO:0050908)2.96274460
33detection of light stimulus involved in sensory perception (GO:0050962)2.96274460
34fucose catabolic process (GO:0019317)2.92838323
35L-fucose metabolic process (GO:0042354)2.92838323
36L-fucose catabolic process (GO:0042355)2.92838323
37retinal rod cell development (GO:0046548)2.91337812
38cilium morphogenesis (GO:0060271)2.89064607
39regulation of sarcomere organization (GO:0060297)2.89009757
40negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.87385663
41positive regulation of glycoprotein biosynthetic process (GO:0010560)2.87190066
42regulation of hexokinase activity (GO:1903299)2.86279443
43regulation of glucokinase activity (GO:0033131)2.86279443
44G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.82063924
45cellular response to type I interferon (GO:0071357)2.75630835
46type I interferon signaling pathway (GO:0060337)2.75630835
47C-terminal protein lipidation (GO:0006501)2.75401501
48ketone body metabolic process (GO:1902224)2.75145387
49histone H2A ubiquitination (GO:0033522)2.70846572
50mannosylation (GO:0097502)2.69535018
51cellular response to interferon-beta (GO:0035458)2.69395356
52negative regulation of JUN kinase activity (GO:0043508)2.68889258
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67330372
54replication fork processing (GO:0031297)2.65979637
55DNA deamination (GO:0045006)2.65517958
56response to type I interferon (GO:0034340)2.65022248
57regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.64970070
58cellular biogenic amine catabolic process (GO:0042402)2.62586623
59amine catabolic process (GO:0009310)2.62586623
60photoreceptor cell development (GO:0042461)2.62302793
61eye photoreceptor cell development (GO:0042462)2.59180973
62GPI anchor metabolic process (GO:0006505)2.57056974
63inositol phosphate catabolic process (GO:0071545)2.56653173
64response to interferon-beta (GO:0035456)2.56399427
65negative regulation of mast cell activation (GO:0033004)2.56303447
66cellular ketone body metabolic process (GO:0046950)2.55199940
67protein complex biogenesis (GO:0070271)2.54694142
68C-terminal protein amino acid modification (GO:0018410)2.53334771
69arginine catabolic process (GO:0006527)2.51091967
70protein-chromophore linkage (GO:0018298)2.51064687
71tryptophan metabolic process (GO:0006568)2.50099146
72negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48808426
73regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.47952873
74regulation of timing of cell differentiation (GO:0048505)2.47819031
75cilium organization (GO:0044782)2.47772800
76phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.47454438
77auditory receptor cell stereocilium organization (GO:0060088)2.47119644
78L-methionine salvage (GO:0071267)2.46661750
79L-methionine biosynthetic process (GO:0071265)2.46661750
80amino acid salvage (GO:0043102)2.46661750
81cilium or flagellum-dependent cell motility (GO:0001539)2.45154389
82cilium assembly (GO:0042384)2.44606066
83anterograde synaptic vesicle transport (GO:0048490)2.44105241
84peptidyl-histidine modification (GO:0018202)2.43226819
85regulation of cilium movement (GO:0003352)2.42961845
86xenobiotic catabolic process (GO:0042178)2.42877144
87dentate gyrus development (GO:0021542)2.42166636
88acrosome reaction (GO:0007340)2.42020561
89negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.41313666
90cell morphogenesis involved in neuron differentiation (GO:0048667)2.41005538
91regulation of acyl-CoA biosynthetic process (GO:0050812)2.41004371
92glycolipid biosynthetic process (GO:0009247)2.40359830
93respiratory chain complex IV assembly (GO:0008535)2.40245715
94cilium movement (GO:0003341)2.39959060
95prenylation (GO:0097354)2.39331283
96protein prenylation (GO:0018342)2.39331283
97multicellular organism reproduction (GO:0032504)2.39318963
98phosphorylated carbohydrate dephosphorylation (GO:0046838)2.38671484
99inositol phosphate dephosphorylation (GO:0046855)2.38671484
100vascular smooth muscle contraction (GO:0014829)2.38271854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1POU3F2_20337985_ChIP-ChIP_501MEL_Human3.09082840
2ZNF274_21170338_ChIP-Seq_K562_Hela2.82627255
3GBX2_23144817_ChIP-Seq_PC3_Human2.80258136
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75850160
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.73786465
6IGF1R_20145208_ChIP-Seq_DFB_Human2.69785860
7VDR_22108803_ChIP-Seq_LS180_Human2.66423514
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.65547425
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61912255
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.38419902
11FUS_26573619_Chip-Seq_HEK293_Human2.35096410
12P300_19829295_ChIP-Seq_ESCs_Human2.34508733
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25257854
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.23636488
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09001558
16TAF15_26573619_Chip-Seq_HEK293_Human2.05252443
17EWS_26573619_Chip-Seq_HEK293_Human2.03174251
18RBPJ_22232070_ChIP-Seq_NCS_Mouse1.97047016
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94181407
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88962294
21ER_23166858_ChIP-Seq_MCF-7_Human1.87425718
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.81000631
23UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77513600
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77447915
25BCAT_22108803_ChIP-Seq_LS180_Human1.76927137
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72650849
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.70206513
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.67434933
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67178519
30ELK1_19687146_ChIP-ChIP_HELA_Human1.66826928
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66755444
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66156499
33SMAD4_21799915_ChIP-Seq_A2780_Human1.65310155
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65066069
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64868321
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64598177
37STAT3_23295773_ChIP-Seq_U87_Human1.57424411
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.53548777
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52018021
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51675905
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51343067
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.51039471
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.49709477
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.48910601
45SOX2_19829295_ChIP-Seq_ESCs_Human1.47941189
46NANOG_19829295_ChIP-Seq_ESCs_Human1.47941189
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44407785
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43682157
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42307125
50AR_25329375_ChIP-Seq_VCAP_Human1.42034338
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41837761
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41136740
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39784790
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.37030264
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35651157
56P53_22387025_ChIP-Seq_ESCs_Mouse1.35271605
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34466334
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34081435
59TCF4_22108803_ChIP-Seq_LS180_Human1.33838757
60IRF1_19129219_ChIP-ChIP_H3396_Human1.33789510
61* CBP_20019798_ChIP-Seq_JUKART_Human1.32552887
62* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32552887
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31810993
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31810993
65* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31617883
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31069131
67GATA1_22025678_ChIP-Seq_K562_Human1.30649355
68CDX2_22108803_ChIP-Seq_LS180_Human1.30359716
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.30103724
70* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29376417
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29040345
72TCF4_23295773_ChIP-Seq_U87_Human1.28524305
73E2F1_18555785_Chip-Seq_ESCs_Mouse1.24974435
74* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23631764
75RUNX2_22187159_ChIP-Seq_PCA_Human1.20666925
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.20325565
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.18975937
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18612336
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.17024860
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.16408634
81FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16037274
82CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15955129
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13201554
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13047830
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12354158
86TP53_22573176_ChIP-Seq_HFKS_Human1.11495480
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09668794
88MYC_18940864_ChIP-ChIP_HL60_Human1.09526213
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.09451993
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08984493
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08984493
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07730785
93P300_18555785_Chip-Seq_ESCs_Mouse1.07678788
94* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06759164
95OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06230168
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06179617
97EST1_17652178_ChIP-ChIP_JURKAT_Human1.05527793
98OCT4_18555785_Chip-Seq_ESCs_Mouse1.05228848
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.04731943
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03829398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation5.31783587
2MP0003195_calcinosis3.39792920
3MP0003950_abnormal_plasma_membrane2.66021297
4MP0002653_abnormal_ependyma_morphology2.61838142
5MP0003136_yellow_coat_color2.54950570
6MP0008789_abnormal_olfactory_epithelium2.46313429
7MP0006054_spinal_hemorrhage2.38611511
8MP0005551_abnormal_eye_electrophysiolog2.37677315
9MP0005253_abnormal_eye_physiology2.20859643
10MP0003880_abnormal_central_pattern2.14685999
11MP0005075_abnormal_melanosome_morpholog2.12293086
12MP0002638_abnormal_pupillary_reflex2.00477164
13MP0000569_abnormal_digit_pigmentation1.96287356
14MP0005084_abnormal_gallbladder_morpholo1.86453984
15MP0003011_delayed_dark_adaptation1.83383449
16MP0002234_abnormal_pharynx_morphology1.82001621
17MP0002163_abnormal_gland_morphology1.79758330
18MP0002736_abnormal_nociception_after1.79242250
19MP0002090_abnormal_vision1.78934156
20MP0005171_absent_coat_pigmentation1.77993127
21MP0001984_abnormal_olfaction1.75970926
22MP0008877_abnormal_DNA_methylation1.70124632
23MP0002102_abnormal_ear_morphology1.70032608
24MP0002928_abnormal_bile_duct1.63123077
25MP0006292_abnormal_olfactory_placode1.57528578
26MP0006276_abnormal_autonomic_nervous1.55879012
27MP0005394_taste/olfaction_phenotype1.54155329
28MP0005499_abnormal_olfactory_system1.54155329
29MP0002876_abnormal_thyroid_physiology1.49288536
30MP0003718_maternal_effect1.39001392
31MP0006072_abnormal_retinal_apoptosis1.38634156
32MP0008057_abnormal_DNA_replication1.37477316
33MP0004147_increased_porphyrin_level1.36926609
34MP0004133_heterotaxia1.35711793
35MP0000015_abnormal_ear_pigmentation1.34308871
36MP0001764_abnormal_homeostasis1.33569911
37MP0003646_muscle_fatigue1.33109323
38MP0006082_CNS_inflammation1.32749803
39MP0000427_abnormal_hair_cycle1.32647866
40MP0010386_abnormal_urinary_bladder1.32334111
41MP0001485_abnormal_pinna_reflex1.32220193
42MP0002254_reproductive_system_inflammat1.31971131
43MP0005379_endocrine/exocrine_gland_phen1.30396586
44MP0005408_hypopigmentation1.30144884
45MP0002095_abnormal_skin_pigmentation1.29548487
46MP0003787_abnormal_imprinting1.26948433
47MP0002938_white_spotting1.26730498
48MP0004142_abnormal_muscle_tone1.26475607
49MP0009780_abnormal_chondrocyte_physiolo1.23978439
50MP0008872_abnormal_physiological_respon1.23348796
51MP0008058_abnormal_DNA_repair1.22046342
52MP0002138_abnormal_hepatobiliary_system1.20186099
53MP0003724_increased_susceptibility_to1.18451242
54MP0000631_abnormal_neuroendocrine_gland1.18202138
55MP0003186_abnormal_redox_activity1.17097922
56MP0002166_altered_tumor_susceptibility1.15775557
57MP0000383_abnormal_hair_follicle1.15014332
58MP0005310_abnormal_salivary_gland1.14746413
59MP0000749_muscle_degeneration1.14705993
60MP0001529_abnormal_vocalization1.13311816
61MP0002233_abnormal_nose_morphology1.06434991
62MP0005670_abnormal_white_adipose1.06404340
63MP0003252_abnormal_bile_duct1.06396488
64MP0009697_abnormal_copulation1.06276521
65MP0008775_abnormal_heart_ventricle1.05766073
66MP0000647_abnormal_sebaceous_gland1.05658014
67MP0005174_abnormal_tail_pigmentation1.03388467
68MP0001968_abnormal_touch/_nociception1.01268462
69MP0001324_abnormal_eye_pigmentation0.99920000
70MP0005395_other_phenotype0.99408614
71MP0001486_abnormal_startle_reflex0.99242429
72MP0004085_abnormal_heartbeat0.98743770
73MP0010678_abnormal_skin_adnexa0.97306617
74MP0004084_abnormal_cardiac_muscle0.97129951
75MP0004484_altered_response_of0.97127180
76MP0000371_diluted_coat_color0.93675939
77MP0002160_abnormal_reproductive_system0.91905377
78MP0002168_other_aberrant_phenotype0.89788097
79MP0005085_abnormal_gallbladder_physiolo0.89676780
80MP0004215_abnormal_myocardial_fiber0.86993875
81MP0008875_abnormal_xenobiotic_pharmacok0.86759135
82MP0001501_abnormal_sleep_pattern0.83518031
83MP0002751_abnormal_autonomic_nervous0.82632671
84MP0000613_abnormal_salivary_gland0.81882419
85MP0010094_abnormal_chromosome_stability0.81548139
86MP0005391_vision/eye_phenotype0.81381904
87MP0005195_abnormal_posterior_eye0.81228642
88MP0005410_abnormal_fertilization0.80727636
89MP0002006_tumorigenesis0.80234541
90MP0009046_muscle_twitch0.79809949
91MP0006036_abnormal_mitochondrial_physio0.79461242
92MP0005646_abnormal_pituitary_gland0.79110005
93MP0002837_dystrophic_cardiac_calcinosis0.79092320
94MP0004145_abnormal_muscle_electrophysio0.78249800
95MP0001293_anophthalmia0.77366240
96MP0008995_early_reproductive_senescence0.76087014
97MP0000230_abnormal_systemic_arterial0.75772862
98MP0001929_abnormal_gametogenesis0.74986648
99MP0005389_reproductive_system_phenotype0.73508103
100MP0000516_abnormal_urinary_system0.73462220

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.23198135
2Congenital stationary night blindness (HP:0007642)3.97480148
3Pancreatic fibrosis (HP:0100732)3.94697110
4Medial flaring of the eyebrow (HP:0010747)3.80006766
5Molar tooth sign on MRI (HP:0002419)3.66715425
6Abnormality of midbrain morphology (HP:0002418)3.66715425
7True hermaphroditism (HP:0010459)3.61051617
8Metaphyseal dysplasia (HP:0100255)3.20143145
9Congenital primary aphakia (HP:0007707)3.19104684
10Gait imbalance (HP:0002141)3.16796228
11Decreased central vision (HP:0007663)3.15756177
12Tubulointerstitial nephritis (HP:0001970)3.09885345
13Popliteal pterygium (HP:0009756)3.02220519
14Nephrogenic diabetes insipidus (HP:0009806)2.93333407
15Hyperventilation (HP:0002883)2.84048144
16Intestinal atresia (HP:0011100)2.76951866
17Chronic hepatic failure (HP:0100626)2.76884259
18Cystic liver disease (HP:0006706)2.68616481
19Type 2 muscle fiber atrophy (HP:0003554)2.64238349
20Hyperglycinemia (HP:0002154)2.60814094
21Genital tract atresia (HP:0001827)2.59648072
22Gaze-evoked nystagmus (HP:0000640)2.59061392
23Abnormality of the renal cortex (HP:0011035)2.56596468
24Aplasia/Hypoplasia of the tibia (HP:0005772)2.54342440
25Progressive inability to walk (HP:0002505)2.51705744
26Nephronophthisis (HP:0000090)2.49085176
27Methylmalonic acidemia (HP:0002912)2.48483163
28Abnormality of the renal medulla (HP:0100957)2.46076434
29Attenuation of retinal blood vessels (HP:0007843)2.46055289
30Vaginal atresia (HP:0000148)2.40741540
31Aplasia/Hypoplasia of the tongue (HP:0010295)2.38202098
32Keratoconus (HP:0000563)2.37740203
33Increased corneal curvature (HP:0100692)2.37740203
34Bifid tongue (HP:0010297)2.35355649
35Abnormality of the fovea (HP:0000493)2.34320245
36Median cleft lip (HP:0000161)2.33033846
37Postaxial hand polydactyly (HP:0001162)2.27846082
38Inability to walk (HP:0002540)2.23702062
39Volvulus (HP:0002580)2.22832627
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.19206564
41Hypoplasia of the fovea (HP:0007750)2.19206564
42Short tibia (HP:0005736)2.18933580
43Renal cortical cysts (HP:0000803)2.17503085
44Tubulointerstitial abnormality (HP:0001969)2.14720951
45Left ventricular hypertrophy (HP:0001712)2.14198021
46Anencephaly (HP:0002323)2.08640279
47Poor coordination (HP:0002370)2.08255810
48Type II lissencephaly (HP:0007260)2.08106027
49Congenital hepatic fibrosis (HP:0002612)2.08042723
50Hyperalaninemia (HP:0003348)2.04011580
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04011580
52Abnormality of alanine metabolism (HP:0010916)2.04011580
53Broad foot (HP:0001769)2.03156135
54Pancreatic islet-cell hyperplasia (HP:0004510)2.02125844
55Methylmalonic aciduria (HP:0012120)2.01664460
56Neonatal respiratory distress (HP:0002643)2.00130798
57Abolished electroretinogram (ERG) (HP:0000550)1.99382549
58Short foot (HP:0001773)1.97127378
59Abnormality of the phalanges of the 2nd finger (HP:0009541)1.96551232
60Hypomagnesemia (HP:0002917)1.95898645
61Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95795679
62Oculomotor apraxia (HP:0000657)1.95133492
63Abnormality of the labia minora (HP:0012880)1.93197896
64Abnormality of macular pigmentation (HP:0008002)1.93147132
65Preaxial hand polydactyly (HP:0001177)1.91736513
66Sclerocornea (HP:0000647)1.91666371
67Abnormality of methionine metabolism (HP:0010901)1.90814134
68Muscle fiber atrophy (HP:0100295)1.90804472
69Astigmatism (HP:0000483)1.90729271
70Febrile seizures (HP:0002373)1.90407427
71Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89879608
72Postaxial foot polydactyly (HP:0001830)1.89694275
73Hypoplastic iliac wings (HP:0002866)1.87209577
74Aplasia/Hypoplasia of the lens (HP:0008063)1.86808067
75Abnormality of the vitamin B12 metabolism (HP:0004341)1.85414074
76Amniotic constriction ring (HP:0009775)1.84663065
77Abnormality of placental membranes (HP:0011409)1.84663065
78Large for gestational age (HP:0001520)1.84627484
79Gastrointestinal atresia (HP:0002589)1.82215987
80Abnormality of the pubic bones (HP:0003172)1.82038138
81Hypoplastic ischia (HP:0003175)1.80212823
82Dyschromatopsia (HP:0007641)1.79890937
83Central scotoma (HP:0000603)1.79435327
84Abnormality of vitamin B metabolism (HP:0004340)1.79376683
85Stomach cancer (HP:0012126)1.79100507
86Tubular atrophy (HP:0000092)1.77407947
87Hypothermia (HP:0002045)1.77279886
88Prominent nasal bridge (HP:0000426)1.76082753
89Disproportionate short-trunk short stature (HP:0003521)1.75698672
90Polydipsia (HP:0001959)1.71949886
91Abnormal drinking behavior (HP:0030082)1.71949886
92Broad-based gait (HP:0002136)1.71441207
93Progressive macrocephaly (HP:0004481)1.70842868
94Calf muscle hypertrophy (HP:0008981)1.70630191
95Furrowed tongue (HP:0000221)1.70376639
96Renal hypoplasia (HP:0000089)1.70137764
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.68607667
98Aplasia/Hypoplasia of the macula (HP:0008059)1.68234392
99Abnormal rod and cone electroretinograms (HP:0008323)1.65963416
100Prostate neoplasm (HP:0100787)1.65066612

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.85067284
2TRIM282.75718308
3NUAK12.51574897
4MAP4K22.42250437
5BMPR1B2.41445912
6CASK2.38947866
7ACVR1B2.18908172
8TAF12.17286775
9EIF2AK32.06349905
10WNK31.95640050
11ADRBK21.95364983
12BRSK21.92482384
13ERBB31.91685013
14STK391.85951024
15IKBKE1.85705292
16MST41.80938013
17PDK21.79219545
18PINK11.74185152
19BCKDK1.72588767
20EIF2AK11.65045314
21PIK3CG1.63309529
22TNIK1.56242556
23GRK11.50885202
24AKT31.47936670
25TIE11.47130932
26MAPK131.40980782
27CCNB11.38864627
28MAP3K41.34577052
29BCR1.32506754
30TEC1.32030983
31FGFR21.31157728
32EPHA31.30810287
33ZAK1.30802186
34FER1.30193408
35OXSR11.29334172
36SGK21.22467050
37MKNK21.20436180
38NLK1.16624377
39PAK31.14992540
40WEE11.12991328
41INSRR1.04331004
42CAMKK21.02117445
43KIT0.93782420
44PLK20.92314470
45TNK20.85643210
46PTK2B0.85529618
47CSNK1G10.85131429
48EIF2AK20.83591203
49FGFR30.82818105
50TAOK30.81971599
51PLK30.79727444
52MKNK10.74754420
53MUSK0.74704212
54MARK10.73777879
55IKBKB0.72544133
56NEK10.71612833
57PRKCE0.71255646
58MAP2K70.68631307
59IRAK10.66090758
60BMPR20.63585822
61NME10.61421096
62TYK20.60885174
63SIK30.59568386
64VRK10.56094546
65SGK30.55266019
66CSNK1G30.54241984
67JAK10.53487633
68STK160.53112897
69SGK4940.52300567
70SGK2230.52300567
71ADRBK10.52058295
72NTRK20.50034476
73CSNK1G20.49008050
74LIMK10.48022407
75TGFBR20.47383007
76CSNK1A1L0.47370504
77FLT30.47351304
78DYRK30.45421530
79RPS6KA40.45121173
80STK30.44478906
81PRKAA20.44058930
82PLK40.43691983
83DAPK20.41687226
84STK40.40304238
85OBSCN0.39116893
86NTRK30.37148781
87DYRK1A0.36403000
88PRKCG0.36337402
89DYRK20.35806853
90BRSK10.35232841
91ABL10.35209641
92CHUK0.34576384
93VRK20.33646955
94PKN10.32166665
95CAMK2A0.32099623
96PRKCQ0.31919070
97PLK10.31758953
98TGFBR10.30568352
99MAPK110.29729137
100GRK50.25047269

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.41844078
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.31403180
3Protein export_Homo sapiens_hsa030603.00043687
4Basal transcription factors_Homo sapiens_hsa030222.72504250
5Propanoate metabolism_Homo sapiens_hsa006402.59892339
6Butanoate metabolism_Homo sapiens_hsa006502.33605673
7Regulation of autophagy_Homo sapiens_hsa041402.26697863
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.15445577
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.15127449
10Caffeine metabolism_Homo sapiens_hsa002322.09788518
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.06819621
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05179171
13Homologous recombination_Homo sapiens_hsa034401.95417247
14Phototransduction_Homo sapiens_hsa047441.93765229
15Fanconi anemia pathway_Homo sapiens_hsa034601.90847269
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.85270421
17Non-homologous end-joining_Homo sapiens_hsa034501.72799116
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71424651
19Proteasome_Homo sapiens_hsa030501.69027013
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65372428
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59737760
22Tryptophan metabolism_Homo sapiens_hsa003801.55703554
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54368268
24Ether lipid metabolism_Homo sapiens_hsa005651.52067986
25Nitrogen metabolism_Homo sapiens_hsa009101.50454601
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49265133
27Linoleic acid metabolism_Homo sapiens_hsa005911.49080795
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44919900
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36191394
30RNA degradation_Homo sapiens_hsa030181.33694321
31Olfactory transduction_Homo sapiens_hsa047401.30647702
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29200569
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24105393
34* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22801154
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19880533
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17469513
37Sphingolipid metabolism_Homo sapiens_hsa006001.15378216
38Steroid biosynthesis_Homo sapiens_hsa001001.15354839
39ABC transporters_Homo sapiens_hsa020101.13564552
40Circadian rhythm_Homo sapiens_hsa047101.06902030
41Retinol metabolism_Homo sapiens_hsa008301.03366954
42Selenocompound metabolism_Homo sapiens_hsa004501.03257392
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01096843
44Nucleotide excision repair_Homo sapiens_hsa034200.99431340
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.97029079
46Chemical carcinogenesis_Homo sapiens_hsa052040.95418047
47Measles_Homo sapiens_hsa051620.94846207
48Fatty acid degradation_Homo sapiens_hsa000710.94741464
49Sulfur metabolism_Homo sapiens_hsa009200.91988970
50Peroxisome_Homo sapiens_hsa041460.90241370
51Glutathione metabolism_Homo sapiens_hsa004800.83311443
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83254101
53Taste transduction_Homo sapiens_hsa047420.79857202
54Collecting duct acid secretion_Homo sapiens_hsa049660.76540805
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72280068
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71677802
57* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68673571
58One carbon pool by folate_Homo sapiens_hsa006700.68519381
59Oxidative phosphorylation_Homo sapiens_hsa001900.65144188
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64358967
61Glycerolipid metabolism_Homo sapiens_hsa005610.64103443
62TGF-beta signaling pathway_Homo sapiens_hsa043500.63261152
63beta-Alanine metabolism_Homo sapiens_hsa004100.62914219
64Fatty acid metabolism_Homo sapiens_hsa012120.62905448
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.62329001
66Metabolic pathways_Homo sapiens_hsa011000.62134967
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59582215
68Herpes simplex infection_Homo sapiens_hsa051680.56735084
69Purine metabolism_Homo sapiens_hsa002300.54815957
70Arachidonic acid metabolism_Homo sapiens_hsa005900.54345260
71Parkinsons disease_Homo sapiens_hsa050120.54275723
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53957546
73Morphine addiction_Homo sapiens_hsa050320.53378025
74Inositol phosphate metabolism_Homo sapiens_hsa005620.52199671
75Salivary secretion_Homo sapiens_hsa049700.51729253
76RNA polymerase_Homo sapiens_hsa030200.51506782
77Serotonergic synapse_Homo sapiens_hsa047260.50121276
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49647803
79Arginine and proline metabolism_Homo sapiens_hsa003300.49121041
80Hepatitis C_Homo sapiens_hsa051600.47100121
81Insulin secretion_Homo sapiens_hsa049110.45922685
82Mineral absorption_Homo sapiens_hsa049780.45252916
83Fatty acid elongation_Homo sapiens_hsa000620.41764644
84p53 signaling pathway_Homo sapiens_hsa041150.41099581
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39599119
86Huntingtons disease_Homo sapiens_hsa050160.37834547
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.37125520
88Fat digestion and absorption_Homo sapiens_hsa049750.35272757
89Hedgehog signaling pathway_Homo sapiens_hsa043400.33995469
90Nicotine addiction_Homo sapiens_hsa050330.33352474
91Tyrosine metabolism_Homo sapiens_hsa003500.30986082
92Oocyte meiosis_Homo sapiens_hsa041140.29967995
93* Jak-STAT signaling pathway_Homo sapiens_hsa046300.29842284
94Influenza A_Homo sapiens_hsa051640.27579075
95Calcium signaling pathway_Homo sapiens_hsa040200.27452879
96N-Glycan biosynthesis_Homo sapiens_hsa005100.27316534
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26901164
98Pyrimidine metabolism_Homo sapiens_hsa002400.26369162
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24898456
100Circadian entrainment_Homo sapiens_hsa047130.23269358

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