IFRD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1wound healing, spreading of epidermal cells (GO:0035313)5.00379980
2response to muramyl dipeptide (GO:0032495)4.77163089
3nuclear pore complex assembly (GO:0051292)4.62134218
4nuclear pore organization (GO:0006999)4.30788829
5negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.25312246
6desmosome organization (GO:0002934)4.22734327
7NIK/NF-kappaB signaling (GO:0038061)4.22021716
8neutrophil mediated immunity (GO:0002446)4.19016486
9neural tube formation (GO:0001841)4.18704968
10wound healing, spreading of cells (GO:0044319)4.08857171
11positive regulation of heat generation (GO:0031652)4.07615955
12protein K11-linked deubiquitination (GO:0035871)4.07167850
13positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.88889832
14protein targeting to Golgi (GO:0000042)3.84711729
15establishment of protein localization to Golgi (GO:0072600)3.82588389
16G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.79408467
17monoubiquitinated protein deubiquitination (GO:0035520)3.68438758
18negative regulation of neurotransmitter transport (GO:0051589)3.64837918
19positive regulation of p38MAPK cascade (GO:1900745)3.62544367
20regulation of fever generation (GO:0031620)3.60757405
21retrograde transport, vesicle recycling within Golgi (GO:0000301)3.59546585
22pore complex assembly (GO:0046931)3.58881631
23myeloid leukocyte mediated immunity (GO:0002444)3.57970569
24interferon-gamma secretion (GO:0072643)3.50901562
25regulation of interleukin-12 biosynthetic process (GO:0045075)3.47565657
26protein K63-linked deubiquitination (GO:0070536)3.40650867
27cell adhesion mediated by integrin (GO:0033627)3.39697369
28keratinocyte proliferation (GO:0043616)3.37305771
29positive thymic T cell selection (GO:0045059)3.35809465
30positive regulation of mitochondrial fission (GO:0090141)3.34657439
31negative regulation of neurotransmitter secretion (GO:0046929)3.31058087
32regulation of heat generation (GO:0031650)3.30808499
33leukocyte migration involved in inflammatory response (GO:0002523)3.28489216
34regulation of mitochondrial fission (GO:0090140)3.28136332
35keratinization (GO:0031424)3.27912758
36regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.25794109
37positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.25794109
38negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.24809933
39negative regulation of T-helper cell differentiation (GO:0045623)3.24809933
40regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.23699887
41neutrophil activation involved in immune response (GO:0002283)3.22063618
42detection of molecule of bacterial origin (GO:0032490)3.17048425
43regulation of cAMP-dependent protein kinase activity (GO:2000479)3.16735324
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.10519031
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.10519031
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.10519031
47modulation by symbiont of host immune response (GO:0052553)3.10519031
48positive regulation by symbiont of host defense response (GO:0052509)3.10519031
49modulation by symbiont of host defense response (GO:0052031)3.10519031
50hemidesmosome assembly (GO:0031581)3.07178984
51pyrimidine dimer repair (GO:0006290)3.02913417
52histamine secretion (GO:0001821)3.00949930
53regulation of MHC class II biosynthetic process (GO:0045346)2.97395214
54negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.97281345
55negative regulation of lipid storage (GO:0010888)2.97172360
56positive regulation of mRNA processing (GO:0050685)2.95891081
57cytoplasmic mRNA processing body assembly (GO:0033962)2.95299684
58negative regulation of stress fiber assembly (GO:0051497)2.94743533
59positive regulation of toll-like receptor signaling pathway (GO:0034123)2.94365371
60negative regulation of NF-kappaB import into nucleus (GO:0042347)2.92376270
61regulation of memory T cell differentiation (GO:0043380)2.91860409
62germinal center formation (GO:0002467)2.90554555
63positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.89152296
64regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.89152296
65dosage compensation (GO:0007549)2.85596313
66negative regulation of DNA recombination (GO:0045910)2.84707783
67regulation of glucokinase activity (GO:0033131)2.82839314
68regulation of hexokinase activity (GO:1903299)2.82839314
69positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.82097646
70CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.81243931
71T-helper cell differentiation (GO:0042093)2.81243931
72protein prenylation (GO:0018342)2.81118316
73prenylation (GO:0097354)2.81118316
74intra-Golgi vesicle-mediated transport (GO:0006891)2.80929020
75cellular response to glucose starvation (GO:0042149)2.80924906
76regulation of p38MAPK cascade (GO:1900744)2.79981883
77natural killer cell mediated cytotoxicity (GO:0042267)2.78176326
78natural killer cell mediated immunity (GO:0002228)2.78176326
79cytokine secretion (GO:0050663)2.75894850
80regulation of water loss via skin (GO:0033561)2.75682730
81regulation of integrin activation (GO:0033623)2.74358963
82histone mRNA catabolic process (GO:0071044)2.73764076
83purinergic nucleotide receptor signaling pathway (GO:0035590)2.72608238
84keratinocyte differentiation (GO:0030216)2.72446666
85positive regulation of mRNA catabolic process (GO:0061014)2.70530916
86microtubule anchoring (GO:0034453)2.69957641
87regulation of type B pancreatic cell apoptotic process (GO:2000674)2.68638169
88positive regulation of mRNA metabolic process (GO:1903313)2.68608935
89glomerular visceral epithelial cell development (GO:0072015)2.67097562
90positive regulation of interleukin-1 beta secretion (GO:0050718)2.66754503
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.66611002
92positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.66114316
93regulation of centriole replication (GO:0046599)2.65300523
94detection of bacterium (GO:0016045)2.63495325
95tolerance induction (GO:0002507)2.63328555
96skin morphogenesis (GO:0043589)2.63182269
97negative regulation of interleukin-8 production (GO:0032717)2.62689514
98negative regulation of interleukin-1 beta production (GO:0032691)2.60815459
99macrophage activation (GO:0042116)2.60023214
100negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.59950028
101N-terminal protein amino acid acetylation (GO:0006474)2.59753613
102negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.59407225
103negative regulation of translation, ncRNA-mediated (GO:0040033)2.59407225
104regulation of translation, ncRNA-mediated (GO:0045974)2.59407225
105protein K48-linked deubiquitination (GO:0071108)2.57917385
106positive regulation of mRNA 3-end processing (GO:0031442)2.57492520
107regulation of chronic inflammatory response (GO:0002676)2.56382656
108positive regulation of interleukin-1 beta production (GO:0032731)2.55960902
109ribonucleoprotein complex disassembly (GO:0032988)2.55903548
110cellular extravasation (GO:0045123)2.55649128
111organelle disassembly (GO:1903008)2.54018850
112necroptotic process (GO:0070266)2.53389211
113regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.52208815
114polyamine biosynthetic process (GO:0006596)2.51642612
115regulation of mRNA catabolic process (GO:0061013)2.51267486
116fatty acid elongation (GO:0030497)2.50591488
117regulation of Rac protein signal transduction (GO:0035020)2.49879784
118detection of other organism (GO:0098543)2.49496974
119modulation by symbiont of host cellular process (GO:0044068)2.49488833
120protein localization to Golgi apparatus (GO:0034067)2.48679899
121positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.48260605
122necrotic cell death (GO:0070265)2.46881039
123establishment of skin barrier (GO:0061436)2.46682994
124regulation of oxidative stress-induced neuron death (GO:1903203)2.44731131
125positive regulation of interleukin-1 secretion (GO:0050716)2.43941490
126response to peptidoglycan (GO:0032494)2.43577009
127negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124)2.43533313
128positive regulation of osteoblast proliferation (GO:0033690)2.43224740
129thymic T cell selection (GO:0045061)2.43106332
130negative regulation of acute inflammatory response (GO:0002674)2.42949047
131regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.42487477
132granulocyte activation (GO:0036230)2.42044628
133I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.41779616
134response to progesterone (GO:0032570)2.41755307
135myeloid dendritic cell differentiation (GO:0043011)2.41680479
136neutrophil activation (GO:0042119)2.40880213
137regulation of NF-kappaB import into nucleus (GO:0042345)2.40869467
138negative regulation of interleukin-12 production (GO:0032695)2.39759714
139positive T cell selection (GO:0043368)2.39109834
140alpha-beta T cell differentiation involved in immune response (GO:0002293)2.38326684
141alpha-beta T cell activation involved in immune response (GO:0002287)2.38326684
142T cell differentiation involved in immune response (GO:0002292)2.38326684
143positive regulation of gamma-delta T cell activation (GO:0046645)2.37707841
144fibroblast migration (GO:0010761)2.37353923
145regulation of germinal center formation (GO:0002634)2.37049820
146snRNA transcription (GO:0009301)2.37041208
147regulation of cell proliferation involved in kidney development (GO:1901722)2.36662510
148detection of biotic stimulus (GO:0009595)2.36395492
149negative regulation of inclusion body assembly (GO:0090084)2.35438275
150iron ion import (GO:0097286)2.35400331
151regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.34771929
152positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.33224849
153mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.33224849
154response to dsRNA (GO:0043331)2.33109702
155regulation of interleukin-1 beta secretion (GO:0050706)2.33087188
156microglial cell activation (GO:0001774)2.32665735
157centriole replication (GO:0007099)2.32084100
158regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.31990040
159tyrosine phosphorylation of STAT protein (GO:0007260)2.31623346
160positive regulation of vasculogenesis (GO:2001214)2.31292870
161regulation of mRNA 3-end processing (GO:0031440)2.30900544
162positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.30855484
163myeloid dendritic cell activation (GO:0001773)2.30180521
164single strand break repair (GO:0000012)2.29482426
165protein K48-linked ubiquitination (GO:0070936)2.28612556
166regulation of monocyte differentiation (GO:0045655)2.28550360
167peptidyl-threonine dephosphorylation (GO:0035970)2.27605394
168regulation of podosome assembly (GO:0071801)2.27527462
169regulation of helicase activity (GO:0051095)2.27000391
170mitochondrial fission (GO:0000266)2.26325541
171glomerular epithelial cell development (GO:0072310)2.26023438
172ER overload response (GO:0006983)2.26011211
173pinocytosis (GO:0006907)2.25686455
174histone H2A acetylation (GO:0043968)2.25557444
175regulation of necroptotic process (GO:0060544)2.24851011
176RNA destabilization (GO:0050779)2.24062979
177interferon-gamma production (GO:0032609)2.23691064
178histamine transport (GO:0051608)2.23681226
179positive regulation of granulocyte differentiation (GO:0030854)2.23622401
180myeloid cell homeostasis (GO:0002262)2.22974868
181regulation of DNA endoreduplication (GO:0032875)2.22900697
182platelet-derived growth factor receptor signaling pathway (GO:0048008)2.22738027
183regulation of interleukin-8 biosynthetic process (GO:0045414)2.22664692
184regulation of interferon-beta biosynthetic process (GO:0045357)2.22459447
185cellular response to arsenic-containing substance (GO:0071243)2.21944457
186nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.21628075
187cellular response to ethanol (GO:0071361)2.21592494
188negative regulation of complement activation (GO:0045916)2.21146319
189positive regulation of Cdc42 GTPase activity (GO:0043089)2.21012182
190regulation of hypersensitivity (GO:0002883)2.20921554
191protein refolding (GO:0042026)2.20767821
192response to laminar fluid shear stress (GO:0034616)2.20582649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.55842295
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.65560394
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.06896346
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.81606534
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.74962276
6* POU3F2_20337985_ChIP-ChIP_501MEL_Human3.41808540
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.41438491
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.24751541
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.94505536
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.88748017
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.76778480
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.63497485
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.63100057
14TAF15_26573619_Chip-Seq_HEK293_Human2.61651842
15* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.55506041
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.51999278
17IGF1R_20145208_ChIP-Seq_DFB_Human2.45981418
18FUS_26573619_Chip-Seq_HEK293_Human2.41299995
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41225102
20EWS_26573619_Chip-Seq_HEK293_Human2.39747061
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.35025455
22GBX2_23144817_ChIP-Seq_PC3_Human2.29686547
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.29219163
24* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.27229021
25* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.27229021
26ELK1_19687146_ChIP-ChIP_HELA_Human2.26861136
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25081515
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23747783
29IRF8_21731497_ChIP-ChIP_J774_Mouse2.15395828
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14157283
31BP1_19119308_ChIP-ChIP_Hs578T_Human2.12748586
32HIF1A_21447827_ChIP-Seq_MCF-7_Human2.12494055
33FOXO3_23340844_ChIP-Seq_DLD1_Human2.08799347
34ESR2_21235772_ChIP-Seq_MCF-7_Human2.03556784
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.02961540
36IRF8_27001747_Chip-Seq_BMDM_Mouse2.02020442
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.96653374
38ZNF274_21170338_ChIP-Seq_K562_Hela1.96558716
39* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93216301
40CLOCK_20551151_ChIP-Seq_293T_Human1.86315680
41P300_19829295_ChIP-Seq_ESCs_Human1.84021862
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.79110994
43CJUN_26792858_Chip-Seq_BT549_Human1.76618715
44* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.76567853
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72395127
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71736806
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69907538
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.67994296
49* ER_23166858_ChIP-Seq_MCF-7_Human1.67771494
50P63_26484246_Chip-Seq_KERATINOCYTES_Human1.66885974
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60707758
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58566609
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57395662
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.56949681
55* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.55955198
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54195258
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53309161
58* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51383431
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.49391320
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.49222231
61IRF1_19129219_ChIP-ChIP_H3396_Human1.48340915
62* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48242209
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47698494
64VDR_24787735_ChIP-Seq_THP-1_Human1.47315508
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.43528350
66* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.43444024
67* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.43157090
68* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42653621
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42527768
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.42527334
71GATA1_22025678_ChIP-Seq_K562_Human1.42125916
72MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41643952
73VDR_22108803_ChIP-Seq_LS180_Human1.40997505
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37926573
75SMAD4_21799915_ChIP-Seq_A2780_Human1.37143885
76RUNX_20019798_ChIP-Seq_JUKART_Human1.36669829
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.36567078
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36517700
79BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35852243
80* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35687412
81* SOX2_20726797_ChIP-Seq_SW620_Human1.35656406
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35389804
83* MYB_26560356_Chip-Seq_TH2_Human1.33406295
84E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33203243
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32917441
86* ATF3_27146783_Chip-Seq_COLON_Human1.32275709
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31957464
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30844154
89* WT1_19549856_ChIP-ChIP_CCG9911_Human1.30741444
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30261432
91* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28039110
92SALL4_22934838_ChIP-ChIP_CD34+_Human1.27909784
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26684683
94VDR_23849224_ChIP-Seq_CD4+_Human1.26634406
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26521882
96CBP_20019798_ChIP-Seq_JUKART_Human1.26521882
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26172725
98* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25725048
99STAT3_23295773_ChIP-Seq_U87_Human1.25223898
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25199831
101BRD4_25478319_ChIP-Seq_HGPS_Human1.25068165
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24259057
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23395732
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21277361
105UBF1/2_26484160_Chip-Seq_HMECs_Human1.20602168
106RXR_22108803_ChIP-Seq_LS180_Human1.19559497
107RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19018447
108SCL_19346495_ChIP-Seq_HPC-7_Human1.18656649
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.17189841
110HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16067144
111FLI1_27457419_Chip-Seq_LIVER_Mouse1.15962691
112GABP_17652178_ChIP-ChIP_JURKAT_Human1.15750730
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15525027
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14401655
115MYB_26560356_Chip-Seq_TH1_Human1.13880488
116KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13254942
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13254942
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13254942
119* FLI1_21867929_ChIP-Seq_TH2_Mouse1.11772896
120* KLF5_25053715_ChIP-Seq_YYC3_Human1.11107397
121RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09675342
122NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08615693
123RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08494279
124SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08424322
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08411929
126VDR_24763502_ChIP-Seq_THP-1_Human1.06866379
127* PU_27001747_Chip-Seq_BMDM_Mouse1.06776673
128NFE2_27457419_Chip-Seq_LIVER_Mouse1.06662199
129RNF2_27304074_Chip-Seq_NSC_Mouse1.05911816
130MAF_26560356_Chip-Seq_TH1_Human1.05661339
131E2F1_18555785_Chip-Seq_ESCs_Mouse1.04774411
132GATA4_25053715_ChIP-Seq_YYC3_Human1.04194042
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03548472
134* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03546378
135GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03488535
136TFEB_21752829_ChIP-Seq_HELA_Human1.03244543
137* AR_25329375_ChIP-Seq_VCAP_Human1.03111001
138FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02251735
139EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02250822
140CDX2_22108803_ChIP-Seq_LS180_Human1.02095476
141TCF7_22412390_ChIP-Seq_EML_Mouse1.01802137
142RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01045965
143IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99862008
144TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99534696
145ELK3_25401928_ChIP-Seq_HUVEC_Human0.99360734
146CRX_20693478_ChIP-Seq_RETINA_Mouse0.98709988
147P53_22387025_ChIP-Seq_ESCs_Mouse0.98672784
148FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97030318
149CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96697733
150TP63_23658742_ChIP-Seq_EP156T_Human0.95714629
151GATA6_25053715_ChIP-Seq_YYC3_Human0.95499659
152TBL1_22424771_ChIP-Seq_293T_Human0.95049791
153RUNX2_22187159_ChIP-Seq_PCA_Human0.94135391
154PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93932036
155CMYC_18555785_Chip-Seq_ESCs_Mouse0.93916103
156RUNX1_22412390_ChIP-Seq_EML_Mouse0.93661284
157ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93353861
158MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93322883
159OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92950485
160POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92621315
161TP53_18474530_ChIP-ChIP_U2OS_Human0.92527609
162RUNX1_27514584_Chip-Seq_MCF-7_Human0.92329066
163SMAD3_21741376_ChIP-Seq_EPCs_Human0.92019389
164SPI1_23547873_ChIP-Seq_NB4_Human0.91164799
165CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90236997
166NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90200963
167ELK1_22589737_ChIP-Seq_MCF10A_Human0.90170368
168JUN_21703547_ChIP-Seq_K562_Human0.90068686
169PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88561698
170CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86011097
171NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84577672
172NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84577672
173TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84149384
174EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84043006
175IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82581321
176* GATA3_27048872_Chip-Seq_THYMUS_Human0.80509335
177HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77774678
178CDX2_20551321_ChIP-Seq_CACO-2_Human0.76356834

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.49325441
2MP0003656_abnormal_erythrocyte_physiolo2.84426416
3MP0004381_abnormal_hair_follicle2.79640463
4MP0004947_skin_inflammation2.73639193
5MP0002796_impaired_skin_barrier2.71430926
6MP0002254_reproductive_system_inflammat2.60224915
7MP0002009_preneoplasia2.52091320
8MP0008058_abnormal_DNA_repair2.51988166
9MP0009697_abnormal_copulation2.51937682
10MP0003453_abnormal_keratinocyte_physiol2.49870825
11MP0003221_abnormal_cardiomyocyte_apopto2.49110445
12MP0002060_abnormal_skin_morphology2.40169816
13MP0001188_hyperpigmentation2.32573568
14MP0001851_eye_inflammation2.31981240
15MP0008877_abnormal_DNA_methylation2.31287148
16MP0003724_increased_susceptibility_to2.27864496
17MP0003941_abnormal_skin_development2.15961711
18MP0005275_abnormal_skin_tensile2.14422379
19MP0003436_decreased_susceptibility_to2.09499274
20MP0001216_abnormal_epidermal_layer2.02702686
21MP0004484_altered_response_of2.02177143
22MP0003566_abnormal_cell_adhesion2.00613029
23MP0000569_abnormal_digit_pigmentation2.00485039
24MP0000383_abnormal_hair_follicle1.93170783
25MP0003303_peritoneal_inflammation1.88637821
26MP0003195_calcinosis1.88437157
27MP0003448_altered_tumor_morphology1.87970609
28MP0002148_abnormal_hypersensitivity_rea1.87198667
29MP0003828_pulmonary_edema1.85949592
30MP0001853_heart_inflammation1.84233587
31MP0010234_abnormal_vibrissa_follicle1.81477542
32MP0002877_abnormal_melanocyte_morpholog1.81239021
33MP0003300_gastrointestinal_ulcer1.80869357
34MP0010352_gastrointestinal_tract_polyps1.78166011
35MP0002006_tumorigenesis1.77913776
36MP0005076_abnormal_cell_differentiation1.76423362
37MP0005000_abnormal_immune_tolerance1.75800209
38MP0005367_renal/urinary_system_phenotyp1.74529027
39MP0000516_abnormal_urinary_system1.74529027
40MP0009278_abnormal_bone_marrow1.72829662
41MP0008007_abnormal_cellular_replicative1.69612376
42MP0002277_abnormal_respiratory_mucosa1.67723365
43MP0002166_altered_tumor_susceptibility1.67130245
44MP0004510_myositis1.66794277
45MP0008260_abnormal_autophagy1.62779510
46MP0000685_abnormal_immune_system1.62005449
47MP0002419_abnormal_innate_immunity1.59774186
48MP0003136_yellow_coat_color1.59062334
49MP0010678_abnormal_skin_adnexa1.59009520
50MP0001790_abnormal_immune_system1.58012983
51MP0005387_immune_system_phenotype1.58012983
52MP0002098_abnormal_vibrissa_morphology1.56452638
53MP0002102_abnormal_ear_morphology1.56220039
54MP0001243_abnormal_dermal_layer1.56172530
55MP0001835_abnormal_antigen_presentation1.53352768
56MP0002452_abnormal_antigen_presenting1.53093037
57MP0000858_altered_metastatic_potential1.52660350
58MP0002332_abnormal_exercise_endurance1.51926827
59MP0005501_abnormal_skin_physiology1.51522259
60MP0001800_abnormal_humoral_immune1.51463776
61MP0002933_joint_inflammation1.51330968
62MP0002723_abnormal_immune_serum1.50499111
63MP0003091_abnormal_cell_migration1.48799654
64MP0003786_premature_aging1.46499866
65MP0002405_respiratory_system_inflammati1.44200902
66MP0005023_abnormal_wound_healing1.42734726
67MP0006054_spinal_hemorrhage1.38787804
68MP0005025_abnormal_response_to1.38306313
69MP0001533_abnormal_skeleton_physiology1.36278672
70MP0003763_abnormal_thymus_physiology1.33431522
71MP0009785_altered_susceptibility_to1.32881107
72MP0000647_abnormal_sebaceous_gland1.28787927
73MP0000627_abnormal_mammary_gland1.28714448
74MP0003890_abnormal_embryonic-extraembry1.28172430
75MP0010771_integument_phenotype1.28128524
76MP0003787_abnormal_imprinting1.27864955
77MP0001191_abnormal_skin_condition1.27149504
78MP0001819_abnormal_immune_cell1.26799892
79MP0002420_abnormal_adaptive_immunity1.26362685
80MP0001873_stomach_inflammation1.26086794
81MP0003705_abnormal_hypodermis_morpholog1.25633987
82MP0009764_decreased_sensitivity_to1.23525051
83MP0002163_abnormal_gland_morphology1.22071424
84MP0005257_abnormal_intraocular_pressure1.20800704
85MP0008995_early_reproductive_senescence1.20736422
86MP0000377_abnormal_hair_follicle1.20645776
87MP0005253_abnormal_eye_physiology1.20012886
88MP0004185_abnormal_adipocyte_glucose1.18562509
89MP0010155_abnormal_intestine_physiology1.18473426
90MP0010094_abnormal_chromosome_stability1.18273260
91MP0005397_hematopoietic_system_phenotyp1.18054596
92MP0001545_abnormal_hematopoietic_system1.18054596
93MP0005390_skeleton_phenotype1.17558713
94MP0008961_abnormal_basal_metabolism1.17513283
95MP0006072_abnormal_retinal_apoptosis1.13392215
96MP0005083_abnormal_biliary_tract1.12118128
97MP0002998_abnormal_bone_remodeling1.11280782
98MP0004215_abnormal_myocardial_fiber1.10904617
99MP0001346_abnormal_lacrimal_gland1.10767115
100MP0000465_gastrointestinal_hemorrhage1.10572854
101MP0009931_abnormal_skin_appearance1.09224625
102MP0000367_abnormal_coat/_hair1.05337897
103MP0002138_abnormal_hepatobiliary_system1.05041367
104MP0001845_abnormal_inflammatory_respons1.04987880
105MP0005187_abnormal_penis_morphology1.03974995
106MP0003077_abnormal_cell_cycle1.03941570
107MP0000427_abnormal_hair_cycle1.01833424
108MP0005266_abnormal_metabolism0.97946134
109MP0001881_abnormal_mammary_gland0.97421061
110MP0005464_abnormal_platelet_physiology0.96402010
111MP0006035_abnormal_mitochondrial_morpho0.95453984
112MP0008438_abnormal_cutaneous_collagen0.95298859
113MP0002090_abnormal_vision0.95209139
114MP0002132_abnormal_respiratory_system0.95168483
115MP0005376_homeostasis/metabolism_phenot0.93785470
116MP0005084_abnormal_gallbladder_morpholo0.93053726
117MP0003186_abnormal_redox_activity0.92864092
118MP0005508_abnormal_skeleton_morphology0.92746560
119MP0005167_abnormal_blood-brain_barrier0.92671054
120MP0006276_abnormal_autonomic_nervous0.91585732
121MP0005174_abnormal_tail_pigmentation0.89797536
122MP0005671_abnormal_response_to0.89701971
123MP0005384_cellular_phenotype0.89097635
124MP0003795_abnormal_bone_structure0.87953268
125MP0000490_abnormal_crypts_of0.87587636
126MP0005248_abnormal_Harderian_gland0.86835273
127MP0005164_abnormal_response_to0.86626346
128MP0004808_abnormal_hematopoietic_stem0.86045260
129MP0003950_abnormal_plasma_membrane0.86008140
130MP0005621_abnormal_cell_physiology0.84427847
131MP0008004_abnormal_stomach_pH0.83256417
132MP0000343_altered_response_to0.83131418
133MP0006082_CNS_inflammation0.83099628
134MP0000372_irregular_coat_pigmentation0.82944918
135MP0004197_abnormal_fetal_growth/weight/0.82524393
136MP0004883_abnormal_blood_vessel0.82488161
137MP0005334_abnormal_fat_pad0.82465894
138MP0002398_abnormal_bone_marrow0.82435426
139MP0001502_abnormal_circadian_rhythm0.81562989
140MP0000358_abnormal_cell_content/0.81457486
141MP0000716_abnormal_immune_system0.81079658
142MP0003121_genomic_imprinting0.80980912
143MP0000015_abnormal_ear_pigmentation0.80871601
144MP0009703_decreased_birth_body0.79265432
145MP0003693_abnormal_embryo_hatching0.79262198
146MP0005451_abnormal_body_composition0.79090210
147MP0001958_emphysema0.78793824
148MP0001879_abnormal_lymphatic_vessel0.77132208
149MP0000470_abnormal_stomach_morphology0.76065378
150MP0000733_abnormal_muscle_development0.76049840
151MP0008932_abnormal_embryonic_tissue0.75104766
152MP0001340_abnormal_eyelid_morphology0.74268887
153MP0009333_abnormal_splenocyte_physiolog0.73513467
154MP0002736_abnormal_nociception_after0.72090317
155MP0003943_abnormal_hepatobiliary_system0.71610429
156MP0003567_abnormal_fetal_cardiomyocyte0.70600348
157MP0005410_abnormal_fertilization0.70199159
158MP0001929_abnormal_gametogenesis0.67910486
159MP0004233_abnormal_muscle_weight0.67356276
160MP0003111_abnormal_nucleus_morphology0.67244197
161MP0010307_abnormal_tumor_latency0.67173370
162MP0002751_abnormal_autonomic_nervous0.65710628
163MP0000631_abnormal_neuroendocrine_gland0.63672224
164MP0001784_abnormal_fluid_regulation0.63360641
165MP0008873_increased_physiological_sensi0.62143516
166MP0002086_abnormal_extraembryonic_tissu0.60832546
167MP0003959_abnormal_lean_body0.60702496
168MP0005646_abnormal_pituitary_gland0.60626453
169MP0001529_abnormal_vocalization0.60474461
170MP0005220_abnormal_exocrine_pancreas0.59447475
171MP0000350_abnormal_cell_proliferation0.58816819
172MP0000230_abnormal_systemic_arterial0.58588902
173MP0000689_abnormal_spleen_morphology0.58530253
174MP0004134_abnormal_chest_morphology0.58354351
175MP0003646_muscle_fatigue0.58204062
176MP0001764_abnormal_homeostasis0.57458378

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.76996362
2Papillary thyroid carcinoma (HP:0002895)4.10117765
3Curly hair (HP:0002212)4.00488221
4Elevated erythrocyte sedimentation rate (HP:0003565)3.90943075
5Anhidrosis (HP:0000970)3.85765243
6Prostate neoplasm (HP:0100787)3.74148207
7Optic neuritis (HP:0100653)3.67268822
8Retrobulbar optic neuritis (HP:0100654)3.67268822
9Orchitis (HP:0100796)3.52285160
10Autoimmune hemolytic anemia (HP:0001890)3.51002211
11Thick nail (HP:0001805)3.45173844
12Eczematoid dermatitis (HP:0000976)3.28589814
13Myositis (HP:0100614)3.27393016
14Recurrent abscess formation (HP:0002722)3.24847945
15Lip pit (HP:0100267)3.24641029
16Thyroid carcinoma (HP:0002890)3.11754620
17Upper limb muscle weakness (HP:0003484)3.01516609
18Recurrent bacterial skin infections (HP:0005406)2.98278774
19Parakeratosis (HP:0001036)2.94964302
20Dyschromatopsia (HP:0007641)2.87479959
21Distal lower limb muscle weakness (HP:0009053)2.87147944
22Prolonged bleeding time (HP:0003010)2.85089688
23Increased mean platelet volume (HP:0011877)2.83337230
24Premature loss of primary teeth (HP:0006323)2.82370767
25Submucous cleft hard palate (HP:0000176)2.77916257
26Cystic hygroma (HP:0000476)2.72180842
27Mediastinal lymphadenopathy (HP:0100721)2.70310402
28Abnormality of the musculature of the pelvis (HP:0001469)2.67660049
29Abnormality of the hip-girdle musculature (HP:0001445)2.67660049
30Gaze-evoked nystagmus (HP:0000640)2.67489475
31Oligodontia (HP:0000677)2.67277049
32Abnormal platelet volume (HP:0011876)2.66437982
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63038875
34Abnormality of alanine metabolism (HP:0010916)2.63038875
35Hyperalaninemia (HP:0003348)2.63038875
36Conical tooth (HP:0000698)2.60286911
37Subacute progressive viral hepatitis (HP:0006572)2.57627946
38Progressive inability to walk (HP:0002505)2.56516935
39Hypotrichosis (HP:0001006)2.54952887
40Pustule (HP:0200039)2.54825901
41Volvulus (HP:0002580)2.51954368
42Hematochezia (HP:0002573)2.48451761
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.46066969
44Episodic fever (HP:0001954)2.43549899
45Pelvic girdle muscle weakness (HP:0003749)2.42620127
46Abnormality of the nasal septum (HP:0000419)2.41972565
47Milia (HP:0001056)2.41909098
48Osteolytic defects of the hand bones (HP:0009699)2.40493470
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.40493470
50Concave nail (HP:0001598)2.39773074
51Bladder carcinoma (HP:0002862)2.36141363
52Bladder neoplasm (HP:0009725)2.36141363
53Plantar hyperkeratosis (HP:0007556)2.34636934
54Periodontitis (HP:0000704)2.33537793
55Fair hair (HP:0002286)2.33221237
56Petechiae (HP:0000967)2.30489468
57Persistence of primary teeth (HP:0006335)2.30403133
58Transitional cell carcinoma of the bladder (HP:0006740)2.29815781
59Medial flaring of the eyebrow (HP:0010747)2.27875698
60Biliary tract neoplasm (HP:0100574)2.27033083
61Pancreatic cysts (HP:0001737)2.26891241
62Pulmonary infiltrates (HP:0002113)2.25973207
63Epiphyseal dysplasia (HP:0002656)2.25656369
64Alveolar cell carcinoma (HP:0006519)2.23556320
65Myocardial infarction (HP:0001658)2.23508727
66Cortical dysplasia (HP:0002539)2.22756527
67Nephrogenic diabetes insipidus (HP:0009806)2.21566444
68Congenital primary aphakia (HP:0007707)2.21362228
69Natal tooth (HP:0000695)2.17484317
70Autoamputation (HP:0001218)2.16940256
71Keratoconjunctivitis sicca (HP:0001097)2.16175010
72Lissencephaly (HP:0001339)2.15567065
73Fragile nails (HP:0001808)2.15472602
74Abnormality of the pons (HP:0007361)2.13340753
75Freckling (HP:0001480)2.13166267
76Atrophic scars (HP:0001075)2.12927206
77Leukocytosis (HP:0001974)2.11317282
78Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.09265873
79Gait imbalance (HP:0002141)2.09101022
80Gingivitis (HP:0000230)2.08897153
81Stomach cancer (HP:0012126)2.08359833
82Acute hepatic failure (HP:0006554)2.08239455
83Enlarged epiphyses (HP:0010580)2.07824838
84Abnormal auditory evoked potentials (HP:0006958)2.07710424
85Increased IgE level (HP:0003212)2.07695421
86Abnormality of the distal phalanges of the toes (HP:0010182)2.06441845
87Vasculitis (HP:0002633)2.05861899
88Menorrhagia (HP:0000132)2.05699041
89Gangrene (HP:0100758)2.05046038
90Gingival bleeding (HP:0000225)2.01604225
91Delayed epiphyseal ossification (HP:0002663)2.00680897
92Palmoplantar hyperkeratosis (HP:0000972)2.00258685
93Aplasia cutis congenita (HP:0001057)1.99688120
94Alopecia of scalp (HP:0002293)1.97513584
95Dyskinesia (HP:0100660)1.97411509
96Keratoconjunctivitis (HP:0001096)1.96031676
97Tetraparesis (HP:0002273)1.95137968
98Pancreatic fibrosis (HP:0100732)1.94664581
99Premature rupture of membranes (HP:0001788)1.93784274
100Vertebral compression fractures (HP:0002953)1.92386180
101Neoplasm of the tracheobronchial system (HP:0100552)1.92326754
102Relative macrocephaly (HP:0004482)1.92041066
103Palmar hyperkeratosis (HP:0010765)1.89278126
104Cupped ribs (HP:0000887)1.89155224
105Thin bony cortex (HP:0002753)1.89051325
106Arterial thrombosis (HP:0004420)1.88741830
107Right ventricular cardiomyopathy (HP:0011663)1.88433103
108Segmental peripheral demyelination/remyelination (HP:0003481)1.88295641
109Abnormality of primary teeth (HP:0006481)1.88022810
110Increased connective tissue (HP:0009025)1.87804564
111Abnormality of macrophages (HP:0004311)1.86633376
112Prominent nose (HP:0000448)1.85614163
113Hydroxyprolinuria (HP:0003080)1.85243816
114Abnormality of proline metabolism (HP:0010907)1.85243816
115Congenital ichthyosiform erythroderma (HP:0007431)1.85157467
116Recurrent fungal infections (HP:0002841)1.84728627
117Eosinophilia (HP:0001880)1.84569199
118Aplasia/Hypoplasia of the tibia (HP:0005772)1.84524663
119Genetic anticipation (HP:0003743)1.84521623
120Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84215934
121Intestinal atresia (HP:0011100)1.83831077
122Acanthocytosis (HP:0001927)1.83596396
123Poor coordination (HP:0002370)1.83220973
124Distal lower limb amyotrophy (HP:0008944)1.83065069
1253-Methylglutaconic aciduria (HP:0003535)1.82214888
126Increased number of teeth (HP:0011069)1.81102241
127Premature skin wrinkling (HP:0100678)1.81067617
128Ectropion (HP:0000656)1.80706468
129Acute myeloid leukemia (HP:0004808)1.80535397
130Hypohidrosis (HP:0000966)1.80391496
131Medulloblastoma (HP:0002885)1.80066979
132Abnormality of the renal cortex (HP:0011035)1.79801266
133Deep philtrum (HP:0002002)1.79058044
134Aqueductal stenosis (HP:0002410)1.79001318
135Drooling (HP:0002307)1.78819361
136Leiomyosarcoma (HP:0100243)1.78184838
137Uterine leiomyosarcoma (HP:0002891)1.78184838
138Long clavicles (HP:0000890)1.77909486
139Type I diabetes mellitus (HP:0100651)1.76565708
140Delayed puberty (HP:0000823)1.76302999
141Woolly hair (HP:0002224)1.75966600
142Metaphyseal dysplasia (HP:0100255)1.75930837
143Barrel-shaped chest (HP:0001552)1.75905356
144Widely spaced teeth (HP:0000687)1.74953172
145Hypoplastic ischia (HP:0003175)1.74778943
146Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74712432
147Degeneration of the lateral corticospinal tracts (HP:0002314)1.74712432
148Generalized hypopigmentation of hair (HP:0011358)1.74676627
149Erythema (HP:0010783)1.74281878
150Interstitial pulmonary disease (HP:0006530)1.73505006
151Cutaneous melanoma (HP:0012056)1.73254874
152Bone pain (HP:0002653)1.72554065
153Shoulder girdle muscle weakness (HP:0003547)1.72275092
154Epistaxis (HP:0000421)1.71262237
155Postnatal microcephaly (HP:0005484)1.71190829
156Breast carcinoma (HP:0003002)1.71148169
157Increased density of long bones (HP:0006392)1.71126293
158Onycholysis (HP:0001806)1.70529031
159Areflexia of lower limbs (HP:0002522)1.70424987
160Specific learning disability (HP:0001328)1.70360353
161Abnormal biliary tract morphology (HP:0012440)1.69758334
162Recurrent skin infections (HP:0001581)1.69622029
163Acanthosis nigricans (HP:0000956)1.69505735
164Chromsome breakage (HP:0040012)1.69486916
165True hermaphroditism (HP:0010459)1.69440507
166Broad foot (HP:0001769)1.68880838
167Autoimmune thrombocytopenia (HP:0001973)1.68840817
168Gonadotropin excess (HP:0000837)1.68625844
169Small epiphyses (HP:0010585)1.67180754
170Excessive salivation (HP:0003781)1.66260685
171Pulmonary artery stenosis (HP:0004415)1.65508694
172Sparse lateral eyebrow (HP:0005338)1.65508249
173Amyloidosis (HP:0011034)1.64663419
174Renal cortical cysts (HP:0000803)1.64576261
175Progressive hearing impairment (HP:0001730)1.64097256
176Sloping forehead (HP:0000340)1.64008461
177Flat acetabular roof (HP:0003180)1.63594035
178Abnormality of chromosome stability (HP:0003220)1.63580382
179Decreased subcutaneous fat (HP:0001002)1.63540139
180Neoplasm of the small intestine (HP:0100833)1.63104483
181Neoplasm of the thyroid gland (HP:0100031)1.61077379
182Tibial bowing (HP:0002982)1.60870768
183Hyperventilation (HP:0002883)1.60307271
184Generalized myoclonic seizures (HP:0002123)1.59989068
185Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59677984
186Hypoplastic iliac wings (HP:0002866)1.58172684
187Abnormality of secondary sexual hair (HP:0009888)1.56969166
188Abnormality of the axillary hair (HP:0100134)1.56969166

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.97510097
2AKT33.69444085
3MAP3K33.30760722
4MAPK153.12600203
5IRAK32.95968729
6SIK32.72189889
7TBK12.66164408
8MST42.63360669
9IRAK22.62341016
10TRIM282.53804882
11IKBKB2.47040353
12FRK2.46784876
13EPHA22.41944152
14ERBB32.35574517
15RPS6KA42.22672693
16PDK22.16215177
17ACVR1B1.97877190
18IKBKE1.94992532
19CHUK1.80255891
20WEE11.79142373
21MAPKAPK31.77821261
22STK101.74023183
23PNCK1.73119170
24SRPK11.72179167
25RIPK11.69009849
26EPHA31.64974100
27MST1R1.60957228
28TGFBR21.59261470
29EPHB11.56050605
30YES11.54990585
31IRAK41.54141615
32NUAK11.52936574
33MAP3K131.52707377
34EIF2AK31.49033318
35TAOK31.48864366
36MAP3K41.48707659
37DYRK31.48298651
38RIPK41.47318160
39NME21.46523824
40CDK61.44384046
41TXK1.44070964
42MAP4K21.43007486
43MKNK21.42442322
44EIF2AK21.40847298
45PAK31.40094815
46MAP2K21.39883873
47MAPKAPK51.39532064
48MOS1.34829727
49TYK21.32915984
50TRPM71.32031009
51CAMKK21.31935982
52FER1.27633008
53MAP3K61.25358703
54PIM21.23753100
55KSR11.23278130
56BRD41.23132645
57PLK21.22667183
58GSK3A1.21400960
59DMPK1.20982980
60EIF2AK11.19666194
61WNK31.18652117
62MAP4K11.16298139
63STK38L1.15946587
64ITK1.15206031
65CAMK1G1.13973242
66TEC1.13016787
67MKNK11.12469935
68NLK1.12184291
69CAMK1D1.08620067
70CDK91.07894603
71PTK61.07606911
72PAK21.05626082
73STK31.04551900
74MAP2K31.03718288
75STK241.03387840
76RPS6KB21.02621599
77PIM11.00238464
78JAK30.98432228
79LATS10.97796528
80RPS6KA50.97769374
81CDK30.95677228
82HCK0.95530715
83JAK10.93412431
84MAP2K40.89995156
85MAP2K70.89544483
86OXSR10.89209083
87MAPKAPK20.88351793
88CSK0.88316346
89TNIK0.88278688
90TTN0.86834503
91IRAK10.84960319
92CDK40.82606684
93ZAP700.81335849
94NEK90.79954741
95SGK20.78995954
96VRK10.78774275
97MAPK130.78605498
98DYRK1A0.77607491
99PLK30.75782041
100ABL10.74979844
101BMX0.74844636
102PDGFRB0.74329949
103CDK120.74316394
104MET0.73989169
105TAOK20.72821248
106PBK0.71705633
107BCR0.69948412
108ZAK0.68536827
109CASK0.67668606
110PIK3CG0.67530319
111CSNK1G10.65943909
112PINK10.64971010
113DYRK1B0.64125590
114TSSK60.63099857
115LCK0.63025736
116CSNK1A1L0.62082829
117RAF10.60587169
118PRKAA20.60221085
119EPHB20.59476283
120CSNK1G20.59472725
121MAP3K110.58137765
122STK390.58093307
123CSNK1G30.58023880
124BMPR20.57779073
125BLK0.56376687
126MAP3K10.56093318
127PTK2B0.54799234
128PTK20.51009347
129MAP3K120.49079399
130MARK30.49005001
131ADRBK10.48328800
132KIT0.48096373
133MAP3K80.46342190
134BMPR1B0.46318716
135MELK0.45521664
136DDR20.45392733
137JAK20.45285184
138GRK70.45205382
139ERBB40.43711132
140MAPK70.43558070
141TAOK10.42201516
142AURKB0.41209195
143ERN10.40693684
144HIPK20.40674817
145LRRK20.40373395
146FGFR30.39880552
147BRSK20.39548107
148TGFBR10.39476491
149PLK40.37782567
150MAP3K20.37275017
151MAP3K50.36519684
152FGR0.36319679
153SGK30.36078623
154PRKAA10.33403452
155PRKCE0.31964331

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.70195305
2NOD-like receptor signaling pathway_Homo sapiens_hsa046212.48485711
3Osteoclast differentiation_Homo sapiens_hsa043802.46666021
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.36014328
5Basal transcription factors_Homo sapiens_hsa030222.35160872
6TNF signaling pathway_Homo sapiens_hsa046682.28941710
7Leishmaniasis_Homo sapiens_hsa051402.23225358
8Regulation of autophagy_Homo sapiens_hsa041402.09512013
9Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.96707305
10Malaria_Homo sapiens_hsa051441.83901498
11Graft-versus-host disease_Homo sapiens_hsa053321.72740579
12Legionellosis_Homo sapiens_hsa051341.70890990
13Hematopoietic cell lineage_Homo sapiens_hsa046401.70718138
14Measles_Homo sapiens_hsa051621.70087102
15Apoptosis_Homo sapiens_hsa042101.67317767
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64432938
17Selenocompound metabolism_Homo sapiens_hsa004501.63715689
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.62944358
19Small cell lung cancer_Homo sapiens_hsa052221.60453555
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59149922
21Toxoplasmosis_Homo sapiens_hsa051451.58366019
22Protein export_Homo sapiens_hsa030601.48761731
23B cell receptor signaling pathway_Homo sapiens_hsa046621.44866954
24p53 signaling pathway_Homo sapiens_hsa041151.44451945
25Influenza A_Homo sapiens_hsa051641.44436851
26T cell receptor signaling pathway_Homo sapiens_hsa046601.44182119
27RNA transport_Homo sapiens_hsa030131.43764012
28Collecting duct acid secretion_Homo sapiens_hsa049661.40564922
29Allograft rejection_Homo sapiens_hsa053301.39075188
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37918523
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36957784
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36507417
33mRNA surveillance pathway_Homo sapiens_hsa030151.36451688
34Pertussis_Homo sapiens_hsa051331.36380955
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35251951
36MicroRNAs in cancer_Homo sapiens_hsa052061.32718191
37Long-term depression_Homo sapiens_hsa047301.31742770
38Bladder cancer_Homo sapiens_hsa052191.31004327
39Rheumatoid arthritis_Homo sapiens_hsa053231.29067994
40ECM-receptor interaction_Homo sapiens_hsa045121.27453611
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.27203657
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26825769
43Non-homologous end-joining_Homo sapiens_hsa034501.26041444
44Circadian rhythm_Homo sapiens_hsa047101.25883292
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25414095
46Sphingolipid metabolism_Homo sapiens_hsa006001.24002544
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23896865
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23097230
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.22228773
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19189571
51Hepatitis B_Homo sapiens_hsa051611.13523788
52HTLV-I infection_Homo sapiens_hsa051661.12031379
53Tuberculosis_Homo sapiens_hsa051521.11678762
54Shigellosis_Homo sapiens_hsa051311.10275330
55Fanconi anemia pathway_Homo sapiens_hsa034601.09052669
56Herpes simplex infection_Homo sapiens_hsa051681.05986049
57Sulfur metabolism_Homo sapiens_hsa009201.05841940
58Hepatitis C_Homo sapiens_hsa051601.05581206
59Nitrogen metabolism_Homo sapiens_hsa009101.04255285
60Antigen processing and presentation_Homo sapiens_hsa046121.03445264
61Alcoholism_Homo sapiens_hsa050341.03182072
62Proteoglycans in cancer_Homo sapiens_hsa052051.01020912
63Chronic myeloid leukemia_Homo sapiens_hsa052200.98650283
64RNA degradation_Homo sapiens_hsa030180.98310446
65Protein digestion and absorption_Homo sapiens_hsa049740.97836642
66Asthma_Homo sapiens_hsa053100.96440567
67Epstein-Barr virus infection_Homo sapiens_hsa051690.96322662
68TGF-beta signaling pathway_Homo sapiens_hsa043500.96151795
69African trypanosomiasis_Homo sapiens_hsa051430.94821446
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94222540
71Acute myeloid leukemia_Homo sapiens_hsa052210.93971088
72Prostate cancer_Homo sapiens_hsa052150.92260565
73Amoebiasis_Homo sapiens_hsa051460.92036565
74Adherens junction_Homo sapiens_hsa045200.91966649
75Cell cycle_Homo sapiens_hsa041100.91891173
76Steroid biosynthesis_Homo sapiens_hsa001000.90860671
77Salmonella infection_Homo sapiens_hsa051320.90225928
78Colorectal cancer_Homo sapiens_hsa052100.89866356
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89146442
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88597040
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88538225
82Spliceosome_Homo sapiens_hsa030400.86437688
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.85059763
84Primary immunodeficiency_Homo sapiens_hsa053400.84891144
85Pancreatic cancer_Homo sapiens_hsa052120.84570575
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.84291936
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82914211
88Viral carcinogenesis_Homo sapiens_hsa052030.80512125
89Dorso-ventral axis formation_Homo sapiens_hsa043200.78040588
90Inositol phosphate metabolism_Homo sapiens_hsa005620.77977187
91Pancreatic secretion_Homo sapiens_hsa049720.77718286
92Focal adhesion_Homo sapiens_hsa045100.76759833
93Serotonergic synapse_Homo sapiens_hsa047260.76626662
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76551135
95FoxO signaling pathway_Homo sapiens_hsa040680.76367108
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75642352
97Oocyte meiosis_Homo sapiens_hsa041140.75413095
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.74856300
99Viral myocarditis_Homo sapiens_hsa054160.74777329
100Glycerolipid metabolism_Homo sapiens_hsa005610.74528070
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72581689
102Melanoma_Homo sapiens_hsa052180.72200515
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71938964
104Chemokine signaling pathway_Homo sapiens_hsa040620.71788576
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71612462
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.70118906
107Mismatch repair_Homo sapiens_hsa034300.69891845
108Choline metabolism in cancer_Homo sapiens_hsa052310.68069604
109MAPK signaling pathway_Homo sapiens_hsa040100.68059280
110Platelet activation_Homo sapiens_hsa046110.67426809
111Arachidonic acid metabolism_Homo sapiens_hsa005900.67096777
112Phagosome_Homo sapiens_hsa041450.67031754
113Endometrial cancer_Homo sapiens_hsa052130.66598680
114Ether lipid metabolism_Homo sapiens_hsa005650.66426593
115Dopaminergic synapse_Homo sapiens_hsa047280.66177626
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65437139
117Pathways in cancer_Homo sapiens_hsa052000.64661103
118Prolactin signaling pathway_Homo sapiens_hsa049170.64301375
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64151665
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64123074
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62545381
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61819634
123Renal cell carcinoma_Homo sapiens_hsa052110.61754429
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60797733
125Staphylococcus aureus infection_Homo sapiens_hsa051500.60630475
126VEGF signaling pathway_Homo sapiens_hsa043700.60182755
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59922535
128HIF-1 signaling pathway_Homo sapiens_hsa040660.59621943
129Non-small cell lung cancer_Homo sapiens_hsa052230.59263660
130ErbB signaling pathway_Homo sapiens_hsa040120.59111545
131Autoimmune thyroid disease_Homo sapiens_hsa053200.58939917
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58663033
133Type I diabetes mellitus_Homo sapiens_hsa049400.57460066
134Lysosome_Homo sapiens_hsa041420.56399699
135Insulin resistance_Homo sapiens_hsa049310.56315951
136Ribosome_Homo sapiens_hsa030100.56058369
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55041005
138Type II diabetes mellitus_Homo sapiens_hsa049300.54755027
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53824641
140Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53023514
141Vitamin digestion and absorption_Homo sapiens_hsa049770.52777557
142Hippo signaling pathway_Homo sapiens_hsa043900.52009392
143Fatty acid elongation_Homo sapiens_hsa000620.51616830
144mTOR signaling pathway_Homo sapiens_hsa041500.50940151
145Fatty acid biosynthesis_Homo sapiens_hsa000610.50904546
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.50442440
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50372781
148Notch signaling pathway_Homo sapiens_hsa043300.49648811
149Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49506224
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43062554
151GABAergic synapse_Homo sapiens_hsa047270.39398270
152Nucleotide excision repair_Homo sapiens_hsa034200.39267620
153Morphine addiction_Homo sapiens_hsa050320.39003945

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