IFRD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)4.89431845
2protoporphyrinogen IX metabolic process (GO:0046501)4.61300353
3protoporphyrinogen IX biosynthetic process (GO:0006782)4.35484658
4DNA unwinding involved in DNA replication (GO:0006268)4.32055484
5protein maturation by protein folding (GO:0022417)4.20983998
6IMP biosynthetic process (GO:0006188)4.12327852
7DNA strand elongation involved in DNA replication (GO:0006271)4.12311933
8deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.10644469
9regulation of mitochondrial translation (GO:0070129)4.09880136
10DNA replication initiation (GO:0006270)3.97946158
11folic acid metabolic process (GO:0046655)3.95174203
12DNA strand elongation (GO:0022616)3.91911676
13heme biosynthetic process (GO:0006783)3.91036215
14nucleobase-containing small molecule interconversion (GO:0015949)3.90510709
15nucleobase biosynthetic process (GO:0046112)3.89566132
16peptidyl-arginine omega-N-methylation (GO:0035247)3.87846563
17establishment of integrated proviral latency (GO:0075713)3.85368524
18formation of translation preinitiation complex (GO:0001731)3.81783893
19protein localization to kinetochore (GO:0034501)3.79296371
20glycine metabolic process (GO:0006544)3.79169476
21telomere maintenance via semi-conservative replication (GO:0032201)3.77449644
22ribosomal small subunit assembly (GO:0000028)3.71674712
23porphyrin-containing compound biosynthetic process (GO:0006779)3.70734426
24IMP metabolic process (GO:0046040)3.68742551
25DNA deamination (GO:0045006)3.61819192
26tetrahydrofolate metabolic process (GO:0046653)3.55078292
27GDP-mannose metabolic process (GO:0019673)3.54249322
28maturation of SSU-rRNA (GO:0030490)3.48108952
29serine family amino acid biosynthetic process (GO:0009070)3.45382736
30proteasome assembly (GO:0043248)3.44385674
31viral transcription (GO:0019083)3.44352524
32purine nucleobase biosynthetic process (GO:0009113)3.44093144
33mitotic nuclear envelope disassembly (GO:0007077)3.41176905
34rRNA modification (GO:0000154)3.40171403
35translational termination (GO:0006415)3.38222701
36pteridine-containing compound biosynthetic process (GO:0042559)3.37768830
37establishment of viral latency (GO:0019043)3.33524101
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.31645073
39Golgi transport vesicle coating (GO:0048200)3.29369547
40COPI coating of Golgi vesicle (GO:0048205)3.29369547
41mitotic nuclear envelope reassembly (GO:0007084)3.26466394
42nuclear envelope reassembly (GO:0031468)3.26466394
43histone arginine methylation (GO:0034969)3.25352695
44lysine metabolic process (GO:0006553)3.25334363
45lysine catabolic process (GO:0006554)3.25334363
46tetrapyrrole biosynthetic process (GO:0033014)3.25036973
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24651365
48translational elongation (GO:0006414)3.23855997
49DNA replication checkpoint (GO:0000076)3.23123978
50heme metabolic process (GO:0042168)3.22982853
51protein localization to chromosome, centromeric region (GO:0071459)3.22793011
52folic acid-containing compound metabolic process (GO:0006760)3.21048260
53regulation of translational fidelity (GO:0006450)3.19330110
54DNA replication-dependent nucleosome assembly (GO:0006335)3.19240161
55DNA replication-dependent nucleosome organization (GO:0034723)3.19240161
56protein targeting to mitochondrion (GO:0006626)3.17594752
57tRNA methylation (GO:0030488)3.16851153
58telomere maintenance via recombination (GO:0000722)3.16100639
59transcription from mitochondrial promoter (GO:0006390)3.15851499
60viral mRNA export from host cell nucleus (GO:0046784)3.15159258
61L-serine metabolic process (GO:0006563)3.14778663
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.13268548
63ribosome biogenesis (GO:0042254)3.12522456
64negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.10423471
65porphyrin-containing compound metabolic process (GO:0006778)3.10400571
66membrane disassembly (GO:0030397)3.10302683
67nuclear envelope disassembly (GO:0051081)3.10302683
68translational initiation (GO:0006413)3.08305675
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06240502
70negative regulation of ligase activity (GO:0051352)3.06240502
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05213363
72rRNA transcription (GO:0009303)3.04750681
73peptidyl-arginine N-methylation (GO:0035246)3.04620798
74peptidyl-arginine methylation (GO:0018216)3.04620798
75serine family amino acid metabolic process (GO:0009069)3.04208248
76one-carbon metabolic process (GO:0006730)3.03671988
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01818622
78positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01787884
79pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.98177534
80pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.97852645
81regulation of mammary gland epithelial cell proliferation (GO:0033599)2.97199875
82ribonucleoprotein complex biogenesis (GO:0022613)2.95996413
83pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.95891653
84nuclear pore organization (GO:0006999)2.94079264
85mitochondrial fusion (GO:0008053)2.93624623
86mitotic recombination (GO:0006312)2.93237632
87NADH metabolic process (GO:0006734)2.92009008
88ribosomal small subunit biogenesis (GO:0042274)2.91836829
89pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.91388752
90cellular component biogenesis (GO:0044085)2.88788148
91guanosine-containing compound biosynthetic process (GO:1901070)2.87429053
92nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.87377101
93telomere maintenance via telomere lengthening (GO:0010833)2.87070313
94regulation of translational termination (GO:0006449)2.85854353
95establishment of protein localization to mitochondrion (GO:0072655)2.85778208
96ribosomal large subunit biogenesis (GO:0042273)2.85604312
97base-excision repair (GO:0006284)2.85520660
98DNA duplex unwinding (GO:0032508)2.84828963
99DNA geometric change (GO:0032392)2.83718636
100spliceosomal snRNP assembly (GO:0000387)2.83154885
101cysteine metabolic process (GO:0006534)2.82417226
102pentose-phosphate shunt (GO:0006098)2.82353288
103pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.82154109
104glucose catabolic process (GO:0006007)2.81051328
105pteridine-containing compound metabolic process (GO:0042558)2.80763193
106spliceosomal tri-snRNP complex assembly (GO:0000244)2.80054332
107SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79237242
108regulation of cellular amino acid metabolic process (GO:0006521)2.78544007
109oxidative phosphorylation (GO:0006119)2.76205728
110mitotic sister chromatid segregation (GO:0000070)2.76116385
111ribosome assembly (GO:0042255)2.75745979
112protein complex localization (GO:0031503)2.73992163
113pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.73858764
1142-deoxyribonucleotide biosynthetic process (GO:0009265)2.73800801
115deoxyribose phosphate biosynthetic process (GO:0046385)2.73800801
116protein localization to mitochondrion (GO:0070585)2.73565233
117pseudouridine synthesis (GO:0001522)2.72530557
118valine metabolic process (GO:0006573)2.72337072
119peptidyl-histidine modification (GO:0018202)2.71073765
120mitotic chromosome condensation (GO:0007076)2.70679080
121positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.70415434
122protein targeting to ER (GO:0045047)2.69809712
123proline biosynthetic process (GO:0006561)2.69686330
124signal transduction involved in DNA integrity checkpoint (GO:0072401)2.69326419
125signal transduction involved in DNA damage checkpoint (GO:0072422)2.69326419
126chaperone-mediated protein transport (GO:0072321)2.69194383
127deoxyribonucleotide biosynthetic process (GO:0009263)2.68970560
128UV protection (GO:0009650)2.68591264
129signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68257027
130intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68257027
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.67831437
132cotranslational protein targeting to membrane (GO:0006613)2.67691648
133nucleotide salvage (GO:0043173)2.66872803
134proline metabolic process (GO:0006560)2.66777203
135rRNA processing (GO:0006364)2.66353504
136nucleotide-excision repair, DNA gap filling (GO:0006297)2.65477716
137mitotic metaphase plate congression (GO:0007080)2.65172244
138nuclear pore complex assembly (GO:0051292)2.64111033
139pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.62768530
140UMP metabolic process (GO:0046049)2.62768530
141pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.62768530
142UMP biosynthetic process (GO:0006222)2.62768530
143pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.62149747
144negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.59946276
1453-UTR-mediated mRNA stabilization (GO:0070935)2.57974855
146rRNA metabolic process (GO:0016072)2.57600784
147cellular protein complex disassembly (GO:0043624)2.56728656
148mitochondrial DNA metabolic process (GO:0032042)2.56272294
149viral life cycle (GO:0019058)2.55774849
150establishment of protein localization to endoplasmic reticulum (GO:0072599)2.55741140
151erythrocyte maturation (GO:0043249)2.55141811
152mitochondrial RNA metabolic process (GO:0000959)2.52063283
153protein localization to endoplasmic reticulum (GO:0070972)2.51659518
154serine family amino acid catabolic process (GO:0009071)2.50811686
155tRNA aminoacylation for protein translation (GO:0006418)2.49914658
156maternal placenta development (GO:0001893)2.48275044
157sister chromatid segregation (GO:0000819)2.48040609
158mitotic G1 DNA damage checkpoint (GO:0031571)2.46785181
159NADPH regeneration (GO:0006740)2.45415538
160pigment biosynthetic process (GO:0046148)2.43053411
161nucleoside salvage (GO:0043174)2.42374774
162tRNA aminoacylation (GO:0043039)2.42208902
163amino acid activation (GO:0043038)2.42208902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.02715586
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.32193527
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.69091815
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.19813882
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81126741
6* ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.63890080
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50654378
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49171566
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47693458
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43634980
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38610449
12MYC_22102868_ChIP-Seq_BL_Human2.18570344
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.18483900
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.15480694
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.15395334
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13939869
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03359589
18* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00384368
19XRN2_22483619_ChIP-Seq_HELA_Human1.95414046
20NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94013045
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.86857926
22AR_21909140_ChIP-Seq_LNCAP_Human1.81991397
23PPARA_22158963_ChIP-Seq_LIVER_Mouse1.73495694
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73387814
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73131060
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70210539
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68979133
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64689802
29* VDR_23849224_ChIP-Seq_CD4+_Human1.64054811
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.63727109
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62983033
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.59475512
33FOXP3_21729870_ChIP-Seq_TREG_Human1.58760977
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57455179
35DCP1A_22483619_ChIP-Seq_HELA_Human1.57165761
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56377646
37* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53261390
38GABP_19822575_ChIP-Seq_HepG2_Human1.53163109
39VDR_21846776_ChIP-Seq_THP-1_Human1.52823576
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52796839
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51294878
42CIITA_25753668_ChIP-Seq_RAJI_Human1.50438600
43GATA1_22025678_ChIP-Seq_K562_Human1.50024570
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.48897401
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48550990
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46508977
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45454984
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41222365
49* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41104597
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40223638
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38274594
52KDM5A_27292631_Chip-Seq_BREAST_Human1.38211968
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37733047
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.35334208
55LXR_22292898_ChIP-Seq_THP-1_Human1.34791165
56* TET1_21451524_ChIP-Seq_MESCs_Mouse1.34647024
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34101555
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29878608
59ZNF263_19887448_ChIP-Seq_K562_Human1.28279294
60* TTF2_22483619_ChIP-Seq_HELA_Human1.27959248
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.26794478
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24997758
63RACK7_27058665_Chip-Seq_MCF-7_Human1.24956720
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23391721
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22872640
66* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18733130
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18399955
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17709448
69* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17160157
70* SRF_21415370_ChIP-Seq_HL-1_Mouse1.16664663
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16467241
72* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16462556
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16348095
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15803339
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15005447
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13907406
77* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13076882
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12197763
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12134824
80* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11366913
81TP63_17297297_ChIP-ChIP_HaCaT_Human1.10152573
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10112459
83TFEB_21752829_ChIP-Seq_HELA_Human1.08059974
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06673629
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06655632
86* P68_20966046_ChIP-Seq_HELA_Human1.06502916
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06187435
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05927264
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05103394
90* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04765839
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04055331
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04009025
93* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03649280
94SCL_19346495_ChIP-Seq_HPC-7_Human1.03502115
95CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02835811
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.02748556
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02223176
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02068619
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00829872
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00706088
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00568677
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00532033
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00473152
104* FOXP1_21924763_ChIP-Seq_HESCs_Human0.99601328
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97823787
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97597122
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97267435
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95909516
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95671927
110KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93821693
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91980311
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91711251
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90870087
114LXR_22158963_ChIP-Seq_LIVER_Mouse0.90723571
115MAF_26560356_Chip-Seq_TH1_Human0.90596124
116POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89558384
117ATF3_27146783_Chip-Seq_COLON_Human0.87475608
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87285624
119ELK1_19687146_ChIP-ChIP_HELA_Human0.86746547
120* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86410044
121ELK3_25401928_ChIP-Seq_HUVEC_Human0.85952139
122UTX_26944678_Chip-Seq_JUKART_Human0.85654147
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85624854
124SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85523565
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83349683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.78710221
2MP0003806_abnormal_nucleotide_metabolis3.74540761
3MP0003656_abnormal_erythrocyte_physiolo3.49367300
4MP0005451_abnormal_body_composition3.41219533
5MP0003111_abnormal_nucleus_morphology3.20468385
6MP0004957_abnormal_blastocyst_morpholog3.03240134
7MP0002139_abnormal_hepatobiliary_system2.99779677
8MP0010094_abnormal_chromosome_stability2.94364268
9MP0002877_abnormal_melanocyte_morpholog2.92228108
10MP0005360_urolithiasis2.86455141
11MP0004147_increased_porphyrin_level2.70701595
12MP0003077_abnormal_cell_cycle2.63466000
13MP0008057_abnormal_DNA_replication2.47640582
14MP0005085_abnormal_gallbladder_physiolo2.41548319
15MP0002396_abnormal_hematopoietic_system2.25301859
16MP0005365_abnormal_bile_salt2.21791356
17MP0004233_abnormal_muscle_weight2.11396364
18MP0005083_abnormal_biliary_tract2.11290500
19MP0010352_gastrointestinal_tract_polyps2.01386143
20MP0009840_abnormal_foam_cell1.88295828
21MP0008260_abnormal_autophagy1.84569672
22MP0001661_extended_life_span1.84023297
23MP0001730_embryonic_growth_arrest1.79039340
24MP0003705_abnormal_hypodermis_morpholog1.78852274
25MP0000751_myopathy1.77983927
26MP0008058_abnormal_DNA_repair1.75695649
27MP0006036_abnormal_mitochondrial_physio1.73561041
28MP0005058_abnormal_lysosome_morphology1.58628509
29MP0005397_hematopoietic_system_phenotyp1.55239407
30MP0001545_abnormal_hematopoietic_system1.55239407
31MP0000490_abnormal_crypts_of1.54478087
32MP0000350_abnormal_cell_proliferation1.53854352
33MP0003186_abnormal_redox_activity1.52113867
34MP0002796_impaired_skin_barrier1.51982583
35MP0009697_abnormal_copulation1.48493069
36MP0008007_abnormal_cellular_replicative1.46251921
37MP0010307_abnormal_tumor_latency1.43189059
38MP0008875_abnormal_xenobiotic_pharmacok1.37522771
39MP0006054_spinal_hemorrhage1.34776682
40MP0010030_abnormal_orbit_morphology1.34323271
41MP0005380_embryogenesis_phenotype1.32170247
42MP0001672_abnormal_embryogenesis/_devel1.32170247
43MP0008932_abnormal_embryonic_tissue1.31277423
44MP0000609_abnormal_liver_physiology1.31268677
45MP0003984_embryonic_growth_retardation1.29999366
46MP0001666_abnormal_nutrient_absorption1.27694080
47MP0002080_prenatal_lethality1.27657670
48MP0002088_abnormal_embryonic_growth/wei1.27550713
49MP0008438_abnormal_cutaneous_collagen1.27535294
50MP0002060_abnormal_skin_morphology1.27213468
51MP0000003_abnormal_adipose_tissue1.26755087
52MP0000678_abnormal_parathyroid_gland1.25019325
53MP0005332_abnormal_amino_acid1.24544482
54MP0005319_abnormal_enzyme/_coenzyme1.24441289
55MP0003315_abnormal_perineum_morphology1.22009356
56MP0002019_abnormal_tumor_incidence1.21506269
57MP0001697_abnormal_embryo_size1.21377776
58MP0005165_increased_susceptibility_to1.21239925
59MP0001849_ear_inflammation1.21000384
60MP0000537_abnormal_urethra_morphology1.20280188
61MP0002086_abnormal_extraembryonic_tissu1.17143697
62MP0010234_abnormal_vibrissa_follicle1.16314011
63MP0000747_muscle_weakness1.15974461
64MP0010329_abnormal_lipoprotein_level1.15950107
65MP0000313_abnormal_cell_death1.14395973
66MP0000598_abnormal_liver_morphology1.14226531
67MP0003191_abnormal_cellular_cholesterol1.12659346
68MP0009333_abnormal_splenocyte_physiolog1.11836240
69MP0006035_abnormal_mitochondrial_morpho1.11782868
70MP0000759_abnormal_skeletal_muscle1.11606892
71MP0003252_abnormal_bile_duct1.11456396
72MP0003567_abnormal_fetal_cardiomyocyte1.11380597
73MP0004808_abnormal_hematopoietic_stem1.09561667
74MP0004197_abnormal_fetal_growth/weight/1.06282676
75MP0002269_muscular_atrophy1.05800748
76MP0000689_abnormal_spleen_morphology1.03811184
77MP0002722_abnormal_immune_system1.03420641
78MP0001764_abnormal_homeostasis1.02190061
79MP0003221_abnormal_cardiomyocyte_apopto1.01042815
80MP0000858_altered_metastatic_potential1.00957245
81MP0005266_abnormal_metabolism1.00866374
82MP0005330_cardiomyopathy0.99113264
83MP0003786_premature_aging0.97891526
84MP0005375_adipose_tissue_phenotype0.97045625
85MP0000358_abnormal_cell_content/0.96695051
86MP0002398_abnormal_bone_marrow0.96101290
87MP0003566_abnormal_cell_adhesion0.95948506
88MP0004858_abnormal_nervous_system0.95615132
89MP0003763_abnormal_thymus_physiology0.93305475
90MP0004264_abnormal_extraembryonic_tissu0.93011423
91MP0003646_muscle_fatigue0.92802200
92MP0001881_abnormal_mammary_gland0.92745405
93MP0001216_abnormal_epidermal_layer0.92101533
94MP0003453_abnormal_keratinocyte_physiol0.92008362
95MP0009643_abnormal_urine_homeostasis0.91977739
96MP0004084_abnormal_cardiac_muscle0.91528000
97MP0002132_abnormal_respiratory_system0.91524845
98MP0003123_paternal_imprinting0.91446650
99MP0005621_abnormal_cell_physiology0.88813741
100MP0000750_abnormal_muscle_regeneration0.88694366
101MP0002085_abnormal_embryonic_tissue0.87987091
102MP0005636_abnormal_mineral_homeostasis0.87638730
103MP0005076_abnormal_cell_differentiation0.87283280
104MP0001243_abnormal_dermal_layer0.86692208
105MP0005384_cellular_phenotype0.84273837
106MP0000703_abnormal_thymus_morphology0.83748829
107MP0009672_abnormal_birth_weight0.82459600
108MP0002429_abnormal_blood_cell0.82239903
109MP0003950_abnormal_plasma_membrane0.81482180
110MP0001853_heart_inflammation0.81165610
111MP0009053_abnormal_anal_canal0.80476103
112MP0005257_abnormal_intraocular_pressure0.80447903
113MP0005501_abnormal_skin_physiology0.79612070
114MP0003718_maternal_effect0.78495670
115MP0002084_abnormal_developmental_patter0.78241955
116MP0001873_stomach_inflammation0.78006345
117MP0010630_abnormal_cardiac_muscle0.77887536
118MP0005023_abnormal_wound_healing0.77711126
119MP0000749_muscle_degeneration0.77261652
120MP0000733_abnormal_muscle_development0.76264291
121MP0001727_abnormal_embryo_implantation0.76044682
122MP0000467_abnormal_esophagus_morphology0.75709140
123MP0005666_abnormal_adipose_tissue0.74781496
124MP0000685_abnormal_immune_system0.73776165
125MP0010771_integument_phenotype0.72489230
126MP0002089_abnormal_postnatal_growth/wei0.72125849
127MP0008775_abnormal_heart_ventricle0.71995700
128MP0000762_abnormal_tongue_morphology0.70673128
129MP0001915_intracranial_hemorrhage0.70518468
130MP0005464_abnormal_platelet_physiology0.70387095
131MP0002970_abnormal_white_adipose0.69990783
132MP0004272_abnormal_basement_membrane0.69552694
133MP0009278_abnormal_bone_marrow0.69300395
134MP0005670_abnormal_white_adipose0.68489198
135MP0004185_abnormal_adipocyte_glucose0.67803854
136MP0004087_abnormal_muscle_fiber0.67758250
137MP0009931_abnormal_skin_appearance0.67225036
138MP0009763_increased_sensitivity_to0.65984163
139MP0002138_abnormal_hepatobiliary_system0.64840420
140MP0000477_abnormal_intestine_morphology0.64686990
141MP0005584_abnormal_enzyme/coenzyme_acti0.63374465

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)5.45017634
2Poikilocytosis (HP:0004447)4.49352836
3Abnormal number of erythroid precursors (HP:0012131)4.18040206
4Abnormality of cells of the erythroid lineage (HP:0012130)4.12953690
5Reticulocytosis (HP:0001923)4.05702681
6Microvesicular hepatic steatosis (HP:0001414)3.80962858
7Abnormality of reticulocytes (HP:0004312)3.66912216
8Acanthocytosis (HP:0001927)3.36582559
9Multiple enchondromatosis (HP:0005701)3.34545008
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.22833152
11Hyperbilirubinemia (HP:0002904)3.20859308
12Abnormality of pyrimidine metabolism (HP:0004353)3.19361511
13Testicular atrophy (HP:0000029)3.18039178
14Abnormality of glycolysis (HP:0004366)3.04745410
15Oral leukoplakia (HP:0002745)2.99751993
16Reticulocytopenia (HP:0001896)2.97951388
17Hypobetalipoproteinemia (HP:0003563)2.97006435
18Birth length less than 3rd percentile (HP:0003561)2.96161030
19Cholelithiasis (HP:0001081)2.94915230
20Hyperammonemia (HP:0001987)2.88121772
21Increased serum pyruvate (HP:0003542)2.87321042
22Hypochromic microcytic anemia (HP:0004840)2.84021624
23Hepatocellular necrosis (HP:0001404)2.81306994
24Myopathic facies (HP:0002058)2.79427553
25Type I transferrin isoform profile (HP:0003642)2.78142582
26Achilles tendon contracture (HP:0001771)2.77421593
27Centrally nucleated skeletal muscle fibers (HP:0003687)2.76558124
28Increased serum ferritin (HP:0003281)2.75404785
29Rhabdomyolysis (HP:0003201)2.74478145
30Increased intramyocellular lipid droplets (HP:0012240)2.73166570
31Vertebral compression fractures (HP:0002953)2.72994331
32Reduced subcutaneous adipose tissue (HP:0003758)2.70571529
33Intrahepatic cholestasis (HP:0001406)2.68076697
34Distal lower limb muscle weakness (HP:0009053)2.63263261
35Increased muscle lipid content (HP:0009058)2.62957068
36Abnormal mitochondria in muscle tissue (HP:0008316)2.61697152
37Abnormality of iron homeostasis (HP:0011031)2.61277269
38Abnormality of the umbilical cord (HP:0010881)2.60698600
39Abnormal gallbladder morphology (HP:0012437)2.56665774
40Hyperglycinuria (HP:0003108)2.55545349
41Ependymoma (HP:0002888)2.54351866
42Macrocytic anemia (HP:0001972)2.52394523
43Exercise intolerance (HP:0003546)2.50034372
44Abnormality of transition element cation homeostasis (HP:0011030)2.48749729
45Exercise-induced myalgia (HP:0003738)2.48422990
46Abnormality of the Achilles tendon (HP:0005109)2.47132513
47Distal lower limb amyotrophy (HP:0008944)2.46796013
48Abnormality of sulfur amino acid metabolism (HP:0004339)2.46706428
49Hypoglycemic coma (HP:0001325)2.46637393
50Nausea (HP:0002018)2.45751391
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41130550
52Hypochromic anemia (HP:0001931)2.41042563
53Abnormality of aromatic amino acid family metabolism (HP:0004338)2.40627178
54Aplastic anemia (HP:0001915)2.39300385
55Progressive muscle weakness (HP:0003323)2.37227313
56Abnormal trabecular bone morphology (HP:0100671)2.34979055
57Pallor (HP:0000980)2.34671175
58Abnormality of glycine metabolism (HP:0010895)2.33953954
59Abnormality of serine family amino acid metabolism (HP:0010894)2.33953954
60Selective tooth agenesis (HP:0001592)2.33602101
61Diaphragmatic weakness (HP:0009113)2.32937504
62Nemaline bodies (HP:0003798)2.32513962
63Spastic diplegia (HP:0001264)2.31593190
64Short nail (HP:0001799)2.31556771
65Myoglobinuria (HP:0002913)2.30793241
66Premature rupture of membranes (HP:0001788)2.28770555
67Deep venous thrombosis (HP:0002625)2.27650276
68Xanthomatosis (HP:0000991)2.26521240
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.26096330
70Dicarboxylic aciduria (HP:0003215)2.26096330
71Lactic acidosis (HP:0003128)2.25488430
72Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.24344593
73Acute encephalopathy (HP:0006846)2.24318400
74Polycythemia (HP:0001901)2.22823691
75Mitochondrial inheritance (HP:0001427)2.22821996
76Acute necrotizing encephalopathy (HP:0006965)2.22628393
77Abnormality of methionine metabolism (HP:0010901)2.20794235
78Hyperglycinemia (HP:0002154)2.20070694
79Abnormal protein N-linked glycosylation (HP:0012347)2.19916298
80Abnormal protein glycosylation (HP:0012346)2.19916298
81Abnormal glycosylation (HP:0012345)2.19916298
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.19916298
83Ketosis (HP:0001946)2.19084742
84Abnormalities of placenta or umbilical cord (HP:0001194)2.18155591
85Thrombocytosis (HP:0001894)2.17916348
86Increased CSF lactate (HP:0002490)2.16832413
87Paralysis (HP:0003470)2.16502504
88Hypolipoproteinemia (HP:0010981)2.15681131
89Muscle fiber inclusion bodies (HP:0100299)2.14832131
90Abnormality of fatty-acid metabolism (HP:0004359)2.14463002
91Muscle stiffness (HP:0003552)2.14398778
92Secondary amenorrhea (HP:0000869)2.13426948
93Premature ovarian failure (HP:0008209)2.12495279
94Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10184883
95Hepatocellular carcinoma (HP:0001402)2.09694235
96Breast hypoplasia (HP:0003187)2.07299430
97Hypergonadotropic hypogonadism (HP:0000815)2.06379269
98Abnormality of serum amino acid levels (HP:0003112)2.05826142
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05390518
100Abnormality of nucleobase metabolism (HP:0010932)2.04658568
101Generalized amyotrophy (HP:0003700)2.04032701
102Basal cell carcinoma (HP:0002671)2.03351179
103Cerebral edema (HP:0002181)2.01654333
104Petechiae (HP:0000967)2.01273426
105Abnormality of the distal phalanges of the toes (HP:0010182)1.99842676
106Abnormality of the fetal cardiovascular system (HP:0010948)1.98361610
107Abnormal umbilical cord blood vessels (HP:0011403)1.98361610
108Single umbilical artery (HP:0001195)1.98361610
109Abnormal cartilage morphology (HP:0002763)1.97259683
110Opisthotonus (HP:0002179)1.96050090
111Microretrognathia (HP:0000308)1.95591917
112Elbow flexion contracture (HP:0002987)1.93685780
113Megaloblastic anemia (HP:0001889)1.92838252
114Cerebral hypomyelination (HP:0006808)1.92593312
115Reduced antithrombin III activity (HP:0001976)1.92431373
116Cholecystitis (HP:0001082)1.92338641
117Abnormal gallbladder physiology (HP:0012438)1.92338641
118Neck muscle weakness (HP:0000467)1.92262754
119Adenoma sebaceum (HP:0009720)1.91705027
120Angiofibromas (HP:0010615)1.91705027
121Microcytic anemia (HP:0001935)1.91591476
122Metabolic acidosis (HP:0001942)1.91038781
123Hypertensive crisis (HP:0100735)1.88862807
124Ragged-red muscle fibers (HP:0003200)1.87065976
125Entropion (HP:0000621)1.87039781
126Hypokinesia (HP:0002375)1.86888793
127Trismus (HP:0000211)1.86125092
128Progressive external ophthalmoplegia (HP:0000590)1.85629744
129Ureteral duplication (HP:0000073)1.85555676
130Fatigue (HP:0012378)1.84995667
131Sparse eyelashes (HP:0000653)1.84106730
132Hyperacusis (HP:0010780)1.82992697
133Exercise-induced muscle cramps (HP:0003710)1.81670738
134Spastic paraparesis (HP:0002313)1.81524925
135Abnormality of the gallbladder (HP:0005264)1.81157095
136Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80709153
137Nonimmune hydrops fetalis (HP:0001790)1.80206174
138Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.79351112
139Carpal bone hypoplasia (HP:0001498)1.78455026
140Increased serum lactate (HP:0002151)1.77877916
141Abnormality of the intrinsic pathway (HP:0010989)1.77674554
142Osteolytic defects of the phalanges of the hand (HP:0009771)1.77346123
143Osteolytic defects of the hand bones (HP:0009699)1.77346123
144Redundant skin (HP:0001582)1.77120903
145Gout (HP:0001997)1.75941873
146Limb-girdle muscle atrophy (HP:0003797)1.75923577
147Ileus (HP:0002595)1.75849111
148Lethargy (HP:0001254)1.73309998
149Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72359875
150Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72359875
151Increased hepatocellular lipid droplets (HP:0006565)1.71757693
152Rhabdomyosarcoma (HP:0002859)1.71182190
153Hepatic necrosis (HP:0002605)1.68875863
154Insulin resistance (HP:0000855)1.67669980
155Late onset (HP:0003584)1.67239497
156Rough bone trabeculation (HP:0100670)1.66717943
157Broad distal phalanx of finger (HP:0009836)1.66534192
158Degeneration of anterior horn cells (HP:0002398)1.65984525
159Abnormality of the anterior horn cell (HP:0006802)1.65984525
160Increased connective tissue (HP:0009025)1.65196165
161Abnormal platelet function (HP:0011869)1.65163170
162Impaired platelet aggregation (HP:0003540)1.65163170
163Hypoalphalipoproteinemia (HP:0003233)1.65102526
164Pancytopenia (HP:0001876)1.62016123
165Abnormality of the common coagulation pathway (HP:0010990)1.61986327
166Squamous cell carcinoma (HP:0002860)1.59849938
167Ketoacidosis (HP:0001993)1.59603025
168Ventricular tachycardia (HP:0004756)1.58580561
169Myelodysplasia (HP:0002863)1.58415214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.91175461
2EIF2AK13.14509175
3BCKDK3.05828346
4SMG13.05524490
5IRAK33.03927452
6CDC73.02419379
7WEE12.98282074
8EEF2K2.88115755
9BUB12.86796927
10PKN22.69868959
11NME22.64834587
12NEK12.61154556
13PBK2.49215353
14TESK12.26794107
15TRIB32.20031972
16NEK22.13980867
17MAP3K102.11402626
18FLT31.96474454
19CDK121.94162505
20MST1R1.90483287
21RPS6KB21.83842982
22ARAF1.81940380
23TTK1.72485052
24STK101.72112276
25ERN11.68764261
26MAP4K11.63849473
27CDK41.56575430
28MAP3K81.52391838
29MAP2K31.52358586
30STK41.46455635
31CDK71.46277245
32TSSK61.44420066
33MAP3K111.43700954
34SCYL21.43661755
35BRSK21.39751053
36TTN1.32294960
37AURKB1.32253934
38PRPF4B1.30018155
39KDR1.29573055
40TLK11.26273577
41DYRK31.25920310
42PLK11.25884520
43LRRK21.24316357
44MAPKAPK31.22002707
45RPS6KA41.21005303
46ATR1.14977969
47PIM11.12705590
48CDK81.12699294
49ACVR1B1.12672040
50TESK21.10902137
51EIF2AK31.10021755
52LIMK11.07924572
53PIM21.04473192
54GRK61.04368326
55DAPK11.03639441
56VRK11.03431470
57MAPK111.02857111
58PAK41.00218391
59PDK20.99236997
60SRPK10.98921724
61BRSK10.98290380
62TAOK20.95659063
63AURKA0.94314875
64TGFBR10.94156109
65EPHA20.93061937
66PASK0.93014013
67CHEK10.91662377
68CHEK20.84062997
69ZAK0.83376708
70TAF10.82031925
71STK160.81349094
72SIK10.79951275
73BRAF0.79406297
74CDK60.78789634
75MTOR0.77644845
76ZAP700.73995927
77LMTK20.73003725
78MAP3K30.68454445
79CCNB10.68237023
80PDK30.66659685
81PDK40.66659685
82RAF10.65471576
83AKT20.65427850
84TYK20.63366435
85CDK20.61642157
86ATM0.60986193
87BRD40.60953212
88ALK0.60651684
89PLK40.59618440
90CSNK2A20.58364252
91BTK0.57218662
92JAK30.57155983
93IRAK20.53548047
94TAOK10.52579453
95ERBB40.51980178
96PTK60.51544346
97MET0.50888182
98CSNK2A10.48195309
99STK30.47086588
100DAPK30.46745293
101PTK20.46369951
102ILK0.45949909
103NME10.45749805
104FGFR40.44709090
105PAK20.44384390
106ICK0.43838521
107PAK10.43709094
108EIF2AK20.43460632
109CDK90.42030805
110RPS6KA50.42003755
111CSF1R0.41422112
112ABL20.41003179
113MOS0.39870235
114OBSCN0.38324900
115CLK10.37228071
116CDK10.36711078
117PLK30.36273728
118BMX0.36171217
119RPS6KA10.35511818
120CSNK1G30.35418859
121MAP2K20.35355826
122MAP3K70.34875026
123JAK20.34646093
124TBK10.32651028
125PRKCI0.32117663
126RPS6KC10.30646384
127RPS6KL10.30646384
128RPS6KA60.30241794
129MAP3K10.28467088
130CAMK2G0.24513049
131MAPKAPK20.24156062
132MST40.23922934

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.80934969
2One carbon pool by folate_Homo sapiens_hsa006703.07127354
3Mismatch repair_Homo sapiens_hsa034302.92331290
4Ribosome_Homo sapiens_hsa030102.51940944
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.31885017
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30753166
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20755897
8Base excision repair_Homo sapiens_hsa034102.10746548
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.10456537
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07077033
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.99058742
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93428524
13Biosynthesis of amino acids_Homo sapiens_hsa012301.92630585
14Spliceosome_Homo sapiens_hsa030401.92015573
15RNA transport_Homo sapiens_hsa030131.90209945
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86666607
17Selenocompound metabolism_Homo sapiens_hsa004501.86540466
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.86104649
19Nucleotide excision repair_Homo sapiens_hsa034201.76132042
20Carbon metabolism_Homo sapiens_hsa012001.75393988
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.72010670
22Pyrimidine metabolism_Homo sapiens_hsa002401.66375017
23Proteasome_Homo sapiens_hsa030501.63496778
24Homologous recombination_Homo sapiens_hsa034401.62346926
25Sulfur relay system_Homo sapiens_hsa041221.60792803
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.56900892
27Folate biosynthesis_Homo sapiens_hsa007901.55652984
28Cell cycle_Homo sapiens_hsa041101.54521640
29Fatty acid degradation_Homo sapiens_hsa000711.52899436
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.50374558
31RNA polymerase_Homo sapiens_hsa030201.49851890
32Pentose phosphate pathway_Homo sapiens_hsa000301.46797679
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46045092
34Fatty acid elongation_Homo sapiens_hsa000621.44835306
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.36650587
36Propanoate metabolism_Homo sapiens_hsa006401.35143902
37Pyruvate metabolism_Homo sapiens_hsa006201.27990450
38Arginine biosynthesis_Homo sapiens_hsa002201.26659120
39Systemic lupus erythematosus_Homo sapiens_hsa053221.24407173
40N-Glycan biosynthesis_Homo sapiens_hsa005101.23997721
41Vitamin B6 metabolism_Homo sapiens_hsa007501.23058297
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21616171
43Tryptophan metabolism_Homo sapiens_hsa003801.16009367
44Oxidative phosphorylation_Homo sapiens_hsa001901.14716318
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14653341
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03916231
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99982574
48RNA degradation_Homo sapiens_hsa030180.97325558
49Fanconi anemia pathway_Homo sapiens_hsa034600.95089860
50beta-Alanine metabolism_Homo sapiens_hsa004100.94445639
51Glutathione metabolism_Homo sapiens_hsa004800.93063567
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92952709
53Huntingtons disease_Homo sapiens_hsa050160.92883599
54Fatty acid metabolism_Homo sapiens_hsa012120.92466152
55Nitrogen metabolism_Homo sapiens_hsa009100.92138419
56p53 signaling pathway_Homo sapiens_hsa041150.91289125
57Arginine and proline metabolism_Homo sapiens_hsa003300.88383546
58Lysine degradation_Homo sapiens_hsa003100.87126295
59Non-homologous end-joining_Homo sapiens_hsa034500.86782791
60Fat digestion and absorption_Homo sapiens_hsa049750.86576320
61Caffeine metabolism_Homo sapiens_hsa002320.85625808
62Peroxisome_Homo sapiens_hsa041460.85455382
63Fructose and mannose metabolism_Homo sapiens_hsa000510.85044388
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81487747
65mRNA surveillance pathway_Homo sapiens_hsa030150.80063983
66Sulfur metabolism_Homo sapiens_hsa009200.79505536
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75446819
68Galactose metabolism_Homo sapiens_hsa000520.74779749
69Other glycan degradation_Homo sapiens_hsa005110.74387206
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70514518
71Alzheimers disease_Homo sapiens_hsa050100.67452055
72Phenylalanine metabolism_Homo sapiens_hsa003600.66718293
73Purine metabolism_Homo sapiens_hsa002300.64634561
74Starch and sucrose metabolism_Homo sapiens_hsa005000.64107175
75Complement and coagulation cascades_Homo sapiens_hsa046100.63893762
76PPAR signaling pathway_Homo sapiens_hsa033200.63593772
77Viral carcinogenesis_Homo sapiens_hsa052030.62774352
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60789181
79Chemical carcinogenesis_Homo sapiens_hsa052040.56730768
80Shigellosis_Homo sapiens_hsa051310.56327068
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55400237
82Herpes simplex infection_Homo sapiens_hsa051680.53629620
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53228207
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51500806
85ABC transporters_Homo sapiens_hsa020100.51482123
86Butanoate metabolism_Homo sapiens_hsa006500.51342001
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50449440
88Metabolic pathways_Homo sapiens_hsa011000.50083349
89Epstein-Barr virus infection_Homo sapiens_hsa051690.46704034
90Antigen processing and presentation_Homo sapiens_hsa046120.46408184
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45556408
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.44911457
93Chronic myeloid leukemia_Homo sapiens_hsa052200.42958830
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42432667
95Vitamin digestion and absorption_Homo sapiens_hsa049770.42129696
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40944747
97Tyrosine metabolism_Homo sapiens_hsa003500.39564783
98Legionellosis_Homo sapiens_hsa051340.39352595
99Small cell lung cancer_Homo sapiens_hsa052220.39246707
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.38159343
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37752109
102Basal transcription factors_Homo sapiens_hsa030220.37696735
103Histidine metabolism_Homo sapiens_hsa003400.37534279
104Vibrio cholerae infection_Homo sapiens_hsa051100.36896429
105Bladder cancer_Homo sapiens_hsa052190.35577762
106Glycerolipid metabolism_Homo sapiens_hsa005610.34293439
107Thyroid cancer_Homo sapiens_hsa052160.33768943
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33373337
109Retinol metabolism_Homo sapiens_hsa008300.33138420
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31537042
111Pancreatic cancer_Homo sapiens_hsa052120.29256852
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27927321
113Apoptosis_Homo sapiens_hsa042100.27843142
114HTLV-I infection_Homo sapiens_hsa051660.27596915
115Acute myeloid leukemia_Homo sapiens_hsa052210.27017937
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23370877
117Bile secretion_Homo sapiens_hsa049760.23305978
118Parkinsons disease_Homo sapiens_hsa050120.21251029
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.20971953
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17146508
121Non-small cell lung cancer_Homo sapiens_hsa052230.16544623
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15488352
123Fatty acid biosynthesis_Homo sapiens_hsa000610.11724493
124Prion diseases_Homo sapiens_hsa050200.11163890

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