IFT122

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Mutations in this gene cause cranioectodermal dysplasia-1. A related pseudogene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.82100504
2axonemal dynein complex assembly (GO:0070286)7.72377573
3fusion of sperm to egg plasma membrane (GO:0007342)7.63695862
4sperm motility (GO:0030317)7.54234585
5epithelial cilium movement (GO:0003351)7.33861698
6piRNA metabolic process (GO:0034587)7.17274048
7cilium movement (GO:0003341)6.93664166
8acrosome reaction (GO:0007340)6.79428400
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.72661470
10motile cilium assembly (GO:0044458)6.43518157
11acrosome assembly (GO:0001675)6.38276678
12plasma membrane fusion (GO:0045026)6.19848630
13sperm-egg recognition (GO:0035036)6.18216485
14male meiosis (GO:0007140)6.15336732
15multicellular organism reproduction (GO:0032504)6.01341018
16spermatid development (GO:0007286)5.79460628
17regulation of cilium movement (GO:0003352)5.79062895
18binding of sperm to zona pellucida (GO:0007339)5.71879616
19synaptonemal complex organization (GO:0070193)5.67622166
20cell-cell recognition (GO:0009988)5.40203430
21synaptonemal complex assembly (GO:0007130)5.16048302
22cell wall macromolecule metabolic process (GO:0044036)4.97643238
23cell wall macromolecule catabolic process (GO:0016998)4.97643238
24reproduction (GO:0000003)4.81565921
25ventricular system development (GO:0021591)4.69466257
26centriole assembly (GO:0098534)4.66224767
27negative regulation of inclusion body assembly (GO:0090084)4.65145319
28DNA methylation involved in gamete generation (GO:0043046)4.58237636
29synapsis (GO:0007129)4.49472491
30single fertilization (GO:0007338)4.47837683
31calcium ion-dependent exocytosis (GO:0017156)4.39253810
32sperm capacitation (GO:0048240)4.09474417
33* intraciliary transport (GO:0042073)4.03423891
34centriole replication (GO:0007099)4.03136139
35regulation of microtubule-based movement (GO:0060632)3.96842551
36fertilization (GO:0009566)3.93961406
37male meiosis I (GO:0007141)3.91663323
38microtubule severing (GO:0051013)3.90198923
39axoneme assembly (GO:0035082)3.83591807
40spermatogenesis (GO:0007283)3.75203490
41male gamete generation (GO:0048232)3.73361205
42* protein localization to cilium (GO:0061512)3.71147308
43regulation of inclusion body assembly (GO:0090083)3.64239306
44protein polyglutamylation (GO:0018095)3.56454876
45germ cell development (GO:0007281)3.49915544
46nonmotile primary cilium assembly (GO:0035058)3.44501249
47gamete generation (GO:0007276)3.43381517
48cellular process involved in reproduction in multicellular organism (GO:0022412)3.41014485
49cell recognition (GO:0008037)3.30676559
50cilium organization (GO:0044782)3.28945587
51meiotic nuclear division (GO:0007126)3.26015163
52microtubule depolymerization (GO:0007019)3.25298529
53* microtubule-based movement (GO:0007018)3.22411635
54seminiferous tubule development (GO:0072520)3.18408951
55* cilium morphogenesis (GO:0060271)3.17992341
56cilium assembly (GO:0042384)3.17898073
57lactate metabolic process (GO:0006089)3.12875520
58chromosome organization involved in meiosis (GO:0070192)3.12561960
59resolution of meiotic recombination intermediates (GO:0000712)3.10031172
60* left/right pattern formation (GO:0060972)3.08379377
61positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.06561828
62histone H2A acetylation (GO:0043968)3.03417396
63organic cation transport (GO:0015695)3.01027605
64behavioral response to nicotine (GO:0035095)3.01010011
65negative regulation of organelle assembly (GO:1902116)2.99204234
66meiosis I (GO:0007127)2.99069786
67cellular component assembly involved in morphogenesis (GO:0010927)2.95476965
68lateral ventricle development (GO:0021670)2.92951078
69membrane depolarization during action potential (GO:0086010)2.91347599
70base-excision repair, AP site formation (GO:0006285)2.88801713
71cell projection assembly (GO:0030031)2.88387042
72spinal cord motor neuron differentiation (GO:0021522)2.88290628
73retinal ganglion cell axon guidance (GO:0031290)2.85448945
74regulation of short-term neuronal synaptic plasticity (GO:0048172)2.85342269
75meiotic chromosome segregation (GO:0045132)2.83962363
76response to misfolded protein (GO:0051788)2.82420014
77regulation of meiosis I (GO:0060631)2.81222733
78brain morphogenesis (GO:0048854)2.80829822
79neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.75624409
80reciprocal meiotic recombination (GO:0007131)2.74520252
81reciprocal DNA recombination (GO:0035825)2.74520252
82urinary tract smooth muscle contraction (GO:0014848)2.73176436
83multicellular organismal reproductive process (GO:0048609)2.72223710
84protein localization to synapse (GO:0035418)2.65532647
85response to pheromone (GO:0019236)2.62808816
86photoreceptor cell maintenance (GO:0045494)2.62426918
87cell differentiation in spinal cord (GO:0021515)2.62067020
88meiotic cell cycle process (GO:1903046)2.61388350
89microtubule bundle formation (GO:0001578)2.61359803
90negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.60391341
91vitamin transmembrane transport (GO:0035461)2.59571779
92regulation of protein kinase A signaling (GO:0010738)2.58623088
93left/right axis specification (GO:0070986)2.58101530
94gene silencing by RNA (GO:0031047)2.55101731
95genitalia morphogenesis (GO:0035112)2.54094366
96meiotic cell cycle (GO:0051321)2.53961732
97lung epithelium development (GO:0060428)2.52925194
98transmission of nerve impulse (GO:0019226)2.52641803
99determination of left/right symmetry (GO:0007368)2.45817413
100microtubule polymerization or depolymerization (GO:0031109)2.45782697
101positive regulation of meiosis (GO:0045836)2.45647273
102protein refolding (GO:0042026)2.44075344
103glutamate secretion (GO:0014047)2.43886736
104protein import into peroxisome matrix (GO:0016558)2.43424031
105detection of calcium ion (GO:0005513)2.43212485
106neuron cell-cell adhesion (GO:0007158)2.42205044
107calcium ion import (GO:0070509)2.42185459
108histone H3-K36 demethylation (GO:0070544)2.40382595
109determination of bilateral symmetry (GO:0009855)2.40239743
110regulation of synaptic vesicle exocytosis (GO:2000300)2.36686031
111organelle assembly (GO:0070925)2.33108432
112regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.32137201
113vocalization behavior (GO:0071625)2.32039628
114positive regulation of smoothened signaling pathway (GO:0045880)2.32007604
115specification of symmetry (GO:0009799)2.31212577
116* smoothened signaling pathway (GO:0007224)2.30608658
117L-fucose catabolic process (GO:0042355)2.30369501
118fucose catabolic process (GO:0019317)2.30369501
119L-fucose metabolic process (GO:0042354)2.30369501
120exploration behavior (GO:0035640)2.29756823
121dendritic spine morphogenesis (GO:0060997)2.28398789
122* appendage development (GO:0048736)2.27221753
123* limb development (GO:0060173)2.27221753
124* microtubule-based process (GO:0007017)2.26509837
125multicellular organismal development (GO:0007275)2.26319392
126innervation (GO:0060384)2.26213013
127positive regulation of meiotic cell cycle (GO:0051446)2.25760783
128establishment of protein localization to Golgi (GO:0072600)2.25317829
129synaptic vesicle exocytosis (GO:0016079)2.25222089
130regulation of collateral sprouting (GO:0048670)2.24997451
131protein targeting to Golgi (GO:0000042)2.24907347
132synaptic vesicle docking involved in exocytosis (GO:0016081)2.24157059
133establishment of nucleus localization (GO:0040023)2.23569798
134histone H3-K9 demethylation (GO:0033169)2.22060605
135DNA methylation (GO:0006306)2.21149774
136DNA alkylation (GO:0006305)2.21149774
137pyrimidine nucleobase catabolic process (GO:0006208)2.20828413
138glycolytic process (GO:0006096)2.20809454
139nucleoside diphosphate phosphorylation (GO:0006165)2.20433404
140presynaptic membrane assembly (GO:0097105)2.20052713
141cochlea development (GO:0090102)2.18789700
142locomotory exploration behavior (GO:0035641)2.17208865
143spermatid nucleus differentiation (GO:0007289)2.16820789
144chaperone-mediated protein complex assembly (GO:0051131)2.16185225
145polyol catabolic process (GO:0046174)2.15115699
146G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.13296850
147regulation of NFAT protein import into nucleus (GO:0051532)2.12599739
148tongue development (GO:0043586)2.11842001
149retinal rod cell development (GO:0046548)2.11713267
150regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.11291019
151cellular ketone body metabolic process (GO:0046950)2.10423931
152nephron epithelium morphogenesis (GO:0072088)2.10007973
153nephron tubule morphogenesis (GO:0072078)2.10007973
154axonal fasciculation (GO:0007413)2.09957578
155behavioral response to ethanol (GO:0048149)2.09623005
156negative regulation of telomere maintenance (GO:0032205)2.08629630
157neurotransmitter-gated ion channel clustering (GO:0072578)2.08121129
158toxin metabolic process (GO:0009404)2.08032596
159* regulation of smoothened signaling pathway (GO:0008589)2.07563921
160primary alcohol catabolic process (GO:0034310)2.06248446
161establishment of tissue polarity (GO:0007164)2.06138486
162establishment of planar polarity (GO:0001736)2.06138486

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.12137365
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.45904786
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.24384984
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.14115471
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66609660
6GBX2_23144817_ChIP-Seq_PC3_Human2.52006076
7CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.47989801
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41986269
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.30679093
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10854378
11REST_21632747_ChIP-Seq_MESCs_Mouse2.09592106
12ZNF274_21170338_ChIP-Seq_K562_Hela2.09439077
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07658931
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97997415
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93956052
16IGF1R_20145208_ChIP-Seq_DFB_Human1.92495602
17VDR_22108803_ChIP-Seq_LS180_Human1.82207284
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70726710
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67187843
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.67090976
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67082894
22SMAD4_21799915_ChIP-Seq_A2780_Human1.64136959
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57902257
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57025338
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54715710
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54498286
27RNF2_27304074_Chip-Seq_NSC_Mouse1.53300893
28ERA_21632823_ChIP-Seq_H3396_Human1.53118724
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.50785488
30TAF15_26573619_Chip-Seq_HEK293_Human1.47768889
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47700026
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.46303786
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.45615340
34DROSHA_22980978_ChIP-Seq_HELA_Human1.44771382
35FUS_26573619_Chip-Seq_HEK293_Human1.43413995
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.43227985
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42592300
38MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38507914
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38446036
40SMC4_20622854_ChIP-Seq_HELA_Human1.37237213
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36391114
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34934311
43CBP_20019798_ChIP-Seq_JUKART_Human1.33646136
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33646136
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32965720
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32594186
47CTCF_27219007_Chip-Seq_Bcells_Human1.32157845
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.31813031
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.31160254
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30553770
51E2F1_17053090_ChIP-ChIP_MCF-7_Human1.30468095
52TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28906196
53P68_20966046_ChIP-Seq_HELA_Human1.28698780
54TCF4_23295773_ChIP-Seq_U87_Human1.28468274
55TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.28389288
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28117420
57RARB_27405468_Chip-Seq_BRAIN_Mouse1.27966704
58YY1_22570637_ChIP-Seq_MALME-3M_Human1.27957042
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27749960
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27094355
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26953050
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26770354
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.25985641
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24972202
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.24703217
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.24622227
67* STAT3_23295773_ChIP-Seq_U87_Human1.23158216
68KDM2B_26808549_Chip-Seq_REH_Human1.22938491
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22820602
70* EP300_21415370_ChIP-Seq_HL-1_Mouse1.22704495
71RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21876135
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21876135
73AR_21572438_ChIP-Seq_LNCaP_Human1.21516006
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20955555
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20955555
76SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20945239
77P300_19829295_ChIP-Seq_ESCs_Human1.20504387
78PHF8_20622854_ChIP-Seq_HELA_Human1.20413435
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.20139498
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19201861
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18843276
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.18672603
83BCAT_22108803_ChIP-Seq_LS180_Human1.17819450
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16112102
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.15860134
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15804583
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14302165
88E2F1_20622854_ChIP-Seq_HELA_Human1.12917355
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12775454
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12042572
91SMAD3_21741376_ChIP-Seq_ESCs_Human1.11762235
92* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11698185
93ER_23166858_ChIP-Seq_MCF-7_Human1.10468935
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10401578
95* TAL1_26923725_Chip-Seq_HPCs_Mouse1.10242764
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09998095
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.09734062
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.09703904
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08850097
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.08752851
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08551463
102MYC_19829295_ChIP-Seq_ESCs_Human1.08339477
103SOX9_26525672_Chip-Seq_HEART_Mouse1.08281326
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06665912
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04873161
106PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04869966
107ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04325976
108* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03966639
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.03670882
110WDR5_24793694_ChIP-Seq_LNCAP_Human1.03054951
111SALL1_21062744_ChIP-ChIP_HESCs_Human1.03030093
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02891138
113ERG_21242973_ChIP-ChIP_JURKAT_Human1.02761460
114TP53_22573176_ChIP-Seq_HFKS_Human1.02461026
115OCT4_20526341_ChIP-Seq_ESCs_Human1.02281005
116STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01661921
117SMAD4_21741376_ChIP-Seq_EPCs_Human1.01185427
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01064916
119AR_25329375_ChIP-Seq_VCAP_Human1.00614388
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00015051
121TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99636815
122GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.99560192
123AHR_22903824_ChIP-Seq_MCF-7_Human0.99325130
124IRF1_19129219_ChIP-ChIP_H3396_Human0.98250693
125* CTCF_20526341_ChIP-Seq_ESCs_Human0.97714131
126TP63_19390658_ChIP-ChIP_HaCaT_Human0.97462022
127CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96880658
128* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96415832
129NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96361846
130YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96090472
131RUNX2_22187159_ChIP-Seq_PCA_Human0.95386906
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.95242263
133TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95218194
134RING1B_27294783_Chip-Seq_ESCs_Mouse0.94861759
135VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94622724
136BCL6_27268052_Chip-Seq_Bcells_Human0.94235779
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93284036
138OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92905574
139AR_19668381_ChIP-Seq_PC3_Human0.92329819
140OCT4_19829295_ChIP-Seq_ESCs_Human0.91749577
141GATA3_21878914_ChIP-Seq_MCF-7_Human0.91370335
142RAC3_21632823_ChIP-Seq_H3396_Human0.90894628
143RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88959980
144LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87848807
145SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.87815569
146NCOR_22424771_ChIP-Seq_293T_Human0.86707564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.38802069
2MP0008877_abnormal_DNA_methylation3.45206459
3MP0000566_synostosis3.21758164
4MP0003698_abnormal_male_reproductive3.20433325
5MP0004270_analgesia2.81771320
6MP0004859_abnormal_synaptic_plasticity2.71453354
7MP0001929_abnormal_gametogenesis2.69026202
8MP0003136_yellow_coat_color2.41634010
9MP0003880_abnormal_central_pattern2.30544422
10MP0000383_abnormal_hair_follicle2.22579397
11MP0001968_abnormal_touch/_nociception2.21870330
12MP0001984_abnormal_olfaction2.12426487
13MP0002653_abnormal_ependyma_morphology2.12412917
14MP0006292_abnormal_olfactory_placode2.12062879
15MP0009780_abnormal_chondrocyte_physiolo2.11257931
16MP0008789_abnormal_olfactory_epithelium2.08998222
17MP0005623_abnormal_meninges_morphology2.08437214
18MP0003635_abnormal_synaptic_transmissio2.08003552
19MP0002735_abnormal_chemical_nociception2.03957875
20MP0005499_abnormal_olfactory_system2.02476051
21MP0005394_taste/olfaction_phenotype2.02476051
22MP0008995_early_reproductive_senescence1.88291878
23MP0002210_abnormal_sex_determination1.86610098
24MP0002736_abnormal_nociception_after1.78550884
25MP0002734_abnormal_mechanical_nocicepti1.75773368
26MP0002938_white_spotting1.75223731
27MP0010030_abnormal_orbit_morphology1.74712595
28MP0002063_abnormal_learning/memory/cond1.73103011
29MP0009745_abnormal_behavioral_response1.72373518
30MP0002161_abnormal_fertility/fecundity1.70621362
31MP0005551_abnormal_eye_electrophysiolog1.70337050
32MP0009046_muscle_twitch1.66797589
33MP0004233_abnormal_muscle_weight1.66343028
34MP0002572_abnormal_emotion/affect_behav1.66170697
35MP0006276_abnormal_autonomic_nervous1.64279406
36MP0001986_abnormal_taste_sensitivity1.63854872
37MP0003122_maternal_imprinting1.56522164
38MP0002249_abnormal_larynx_morphology1.56496568
39MP0006072_abnormal_retinal_apoptosis1.55380262
40MP0000751_myopathy1.54044656
41MP0005423_abnormal_somatic_nervous1.54042204
42MP0009278_abnormal_bone_marrow1.52888588
43MP0001145_abnormal_male_reproductive1.52441516
44MP0002272_abnormal_nervous_system1.49124567
45MP0008875_abnormal_xenobiotic_pharmacok1.44676121
46MP0002064_seizures1.43369323
47MP0003787_abnormal_imprinting1.43052250
48MP0001440_abnormal_grooming_behavior1.41944001
49MP0005670_abnormal_white_adipose1.40191744
50MP0000778_abnormal_nervous_system1.38837907
51MP0000049_abnormal_middle_ear1.37966249
52MP0002102_abnormal_ear_morphology1.37213076
53MP0003283_abnormal_digestive_organ1.36412207
54MP0004858_abnormal_nervous_system1.33298306
55MP0000653_abnormal_sex_gland1.32796772
56MP0002733_abnormal_thermal_nociception1.30338420
57MP0005253_abnormal_eye_physiology1.30200704
58MP0000026_abnormal_inner_ear1.29821704
59MP0002184_abnormal_innervation1.28542477
60MP0003938_abnormal_ear_development1.27527713
61MP0002067_abnormal_sensory_capabilities1.26472090
62MP0001485_abnormal_pinna_reflex1.25217675
63MP0005645_abnormal_hypothalamus_physiol1.24692699
64MP0001486_abnormal_startle_reflex1.23182244
65MP0002160_abnormal_reproductive_system1.21778472
66MP0002837_dystrophic_cardiac_calcinosis1.20466629
67MP0002882_abnormal_neuron_morphology1.15720605
68MP0004145_abnormal_muscle_electrophysio1.13922277
69MP0001970_abnormal_pain_threshold1.12271171
70MP0002234_abnormal_pharynx_morphology1.11571689
71MP0004811_abnormal_neuron_physiology1.10934376
72MP0003329_amyloid_beta_deposits1.10577498
73MP0010678_abnormal_skin_adnexa1.07984493
74MP0008058_abnormal_DNA_repair1.07760773
75MP0002928_abnormal_bile_duct1.07649626
76MP0005646_abnormal_pituitary_gland1.05655638
77MP0000955_abnormal_spinal_cord1.05115292
78MP0002557_abnormal_social/conspecific_i1.04566286
79MP0003942_abnormal_urinary_system1.04358999
80MP0000534_abnormal_ureter_morphology1.02575858
81MP0000013_abnormal_adipose_tissue1.01192969
82MP0002282_abnormal_trachea_morphology1.00944041
83MP0003879_abnormal_hair_cell1.00521155
84MP0003123_paternal_imprinting1.00165847
85MP0004742_abnormal_vestibular_system0.99880672
86MP0010386_abnormal_urinary_bladder0.99808459
87MP0001293_anophthalmia0.99420304
88MP0003119_abnormal_digestive_system0.99087828
89MP0002638_abnormal_pupillary_reflex0.98438843
90MP0005503_abnormal_tendon_morphology0.97579411
91MP0005389_reproductive_system_phenotype0.95738823
92MP0002152_abnormal_brain_morphology0.94083128
93MP0005220_abnormal_exocrine_pancreas0.93398605
94MP0000427_abnormal_hair_cycle0.92448145
95MP0003121_genomic_imprinting0.92355081
96MP0001529_abnormal_vocalization0.91653300
97MP0002116_abnormal_craniofacial_bone0.91184528
98MP0003011_delayed_dark_adaptation0.90129994
99MP0005377_hearing/vestibular/ear_phenot0.89673029
100MP0003878_abnormal_ear_physiology0.89673029
101MP0002909_abnormal_adrenal_gland0.89297389
102MP0005391_vision/eye_phenotype0.88893549
103MP0001502_abnormal_circadian_rhythm0.87945808
104MP0002752_abnormal_somatic_nervous0.87343553
105MP0001299_abnormal_eye_distance/0.87191229
106MP0000631_abnormal_neuroendocrine_gland0.86917303
107MP0000678_abnormal_parathyroid_gland0.86773272
108MP0004036_abnormal_muscle_relaxation0.85735092
109MP0001765_abnormal_ion_homeostasis0.85638633
110MP0002229_neurodegeneration0.84439713
111MP0004043_abnormal_pH_regulation0.84316109
112MP0000749_muscle_degeneration0.82610529
113MP0004085_abnormal_heartbeat0.82473300
114MP0001270_distended_abdomen0.81436034
115MP0001905_abnormal_dopamine_level0.81137971
116MP0004133_heterotaxia0.79932394
117MP0002876_abnormal_thyroid_physiology0.79833537
118MP0005171_absent_coat_pigmentation0.79243461
119MP0003937_abnormal_limbs/digits/tail_de0.78823315
120MP0004885_abnormal_endolymph0.78814702
121MP0004924_abnormal_behavior0.78381091
122MP0005386_behavior/neurological_phenoty0.78381091
123MP0004215_abnormal_myocardial_fiber0.78210558
124MP0003634_abnormal_glial_cell0.77959992
125MP0008569_lethality_at_weaning0.77128715
126MP0003861_abnormal_nervous_system0.76684816
127MP0002066_abnormal_motor_capabilities/c0.76296735
128MP0002233_abnormal_nose_morphology0.76187791
129MP0002822_catalepsy0.75780866
130MP0003633_abnormal_nervous_system0.75566582
131MP0000569_abnormal_digit_pigmentation0.73297337
132MP0005195_abnormal_posterior_eye0.73273577
133MP0001963_abnormal_hearing_physiology0.68509122
134MP0003183_abnormal_peptide_metabolism0.67667413
135MP0001324_abnormal_eye_pigmentation0.66928997
136MP0004272_abnormal_basement_membrane0.65616990

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.98210793
2Absent/shortened dynein arms (HP:0200106)8.99096512
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.99096512
4Abnormal respiratory motile cilium physiology (HP:0012261)7.27501160
5Abnormal respiratory epithelium morphology (HP:0012253)6.48348881
6Abnormal respiratory motile cilium morphology (HP:0005938)6.48348881
7Abnormal ciliary motility (HP:0012262)6.00956570
8Rhinitis (HP:0012384)6.00736541
9Chronic bronchitis (HP:0004469)5.42363347
10Infertility (HP:0000789)4.46289971
11Nephronophthisis (HP:0000090)4.06095139
12Medial flaring of the eyebrow (HP:0010747)3.36009759
13Abnormality of the renal medulla (HP:0100957)3.33411718
14Abnormality of the lower motor neuron (HP:0002366)3.31410929
15Nasal polyposis (HP:0100582)3.23235295
16Abnormality of midbrain morphology (HP:0002418)3.12753601
17Molar tooth sign on MRI (HP:0002419)3.12753601
18Bronchiectasis (HP:0002110)2.98999222
19Anencephaly (HP:0002323)2.81829130
20Gait imbalance (HP:0002141)2.74960880
21Sclerocornea (HP:0000647)2.62975601
22Congenital primary aphakia (HP:0007707)2.60412588
23Preaxial hand polydactyly (HP:0001177)2.55534596
24Male infertility (HP:0003251)2.54110764
25Abnormality of the nasal mucosa (HP:0000433)2.52160333
26Cerebellar dysplasia (HP:0007033)2.41505300
27Nephrogenic diabetes insipidus (HP:0009806)2.39664425
28Supernumerary spleens (HP:0009799)2.38460978
29Bronchitis (HP:0012387)2.37726506
30Tubular atrophy (HP:0000092)2.34339546
31Genital tract atresia (HP:0001827)2.33012080
32Pancreatic fibrosis (HP:0100732)2.32962779
33Abnormal drinking behavior (HP:0030082)2.31457258
34Polydipsia (HP:0001959)2.31457258
35Atelectasis (HP:0100750)2.28185377
36Postaxial foot polydactyly (HP:0001830)2.26770270
37Vaginal atresia (HP:0000148)2.26243441
38Postaxial hand polydactyly (HP:0001162)2.10305030
39Chronic sinusitis (HP:0011109)2.10303784
40Amyotrophic lateral sclerosis (HP:0007354)2.08028485
41Abnormality of the renal cortex (HP:0011035)2.03062580
42True hermaphroditism (HP:0010459)2.02962152
43Poor coordination (HP:0002370)2.02708754
44Epileptic encephalopathy (HP:0200134)2.02227252
45Aplasia/Hypoplasia of the lens (HP:0008063)1.97882900
46Stage 5 chronic kidney disease (HP:0003774)1.96857268
47Male pseudohermaphroditism (HP:0000037)1.94737847
48Central scotoma (HP:0000603)1.93483702
49Optic nerve coloboma (HP:0000588)1.90003941
50Concave nail (HP:0001598)1.88688709
51Focal seizures (HP:0007359)1.88388475
52Narrow forehead (HP:0000341)1.85592938
53Congenital hepatic fibrosis (HP:0002612)1.85179965
54Gonadotropin excess (HP:0000837)1.84816144
55Multicystic kidney dysplasia (HP:0000003)1.84188740
56Oculomotor apraxia (HP:0000657)1.80681305
57Polyphagia (HP:0002591)1.80470307
58Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78942246
59Abnormality of macular pigmentation (HP:0008002)1.78039329
60Recurrent otitis media (HP:0000403)1.77160218
61Polycystic kidney dysplasia (HP:0000113)1.76380715
62Flat capital femoral epiphysis (HP:0003370)1.76015174
63Retinal dysplasia (HP:0007973)1.75042871
64Prominent nasal bridge (HP:0000426)1.74781344
65Renal dysplasia (HP:0000110)1.74693712
66Gaze-evoked nystagmus (HP:0000640)1.73552855
67Abdominal situs inversus (HP:0003363)1.73500779
68Abnormality of abdominal situs (HP:0011620)1.73500779
69* Tubulointerstitial abnormality (HP:0001969)1.72959358
70* Tubulointerstitial nephritis (HP:0001970)1.72800020
71Highly arched eyebrow (HP:0002553)1.72232683
72Hemiparesis (HP:0001269)1.71502434
73Progressive cerebellar ataxia (HP:0002073)1.70011568
74Aplasia/Hypoplasia of the tongue (HP:0010295)1.69952165
75Abnormality of the labia minora (HP:0012880)1.69307563
76Atonic seizures (HP:0010819)1.67017778
77Holoprosencephaly (HP:0001360)1.66953172
78Neoplasm of the heart (HP:0100544)1.66896054
79Choroideremia (HP:0001139)1.66271021
80Abnormality of the diencephalon (HP:0010662)1.66270075
81Short thorax (HP:0010306)1.66219634
82Bifid tongue (HP:0010297)1.64178348
83Aganglionic megacolon (HP:0002251)1.64021983
84Focal motor seizures (HP:0011153)1.62462152
85Decreased central vision (HP:0007663)1.62256914
86Pheochromocytoma (HP:0002666)1.62076621
87Bell-shaped thorax (HP:0001591)1.61730468
88Polyuria (HP:0000103)1.61127709
89Tubulointerstitial fibrosis (HP:0005576)1.60923837
90* Cystic liver disease (HP:0006706)1.60893751
91Abnormality of renal excretion (HP:0011036)1.60775119
92Absent speech (HP:0001344)1.60243171
93Ankle clonus (HP:0011448)1.59702428
94Ependymoma (HP:0002888)1.59627644
95Neurofibrillary tangles (HP:0002185)1.58019487
96Abnormal urine output (HP:0012590)1.57876154
97Retinitis pigmentosa (HP:0000510)1.57342440
98Chronic hepatic failure (HP:0100626)1.56494034
99* Abnormality of dentin (HP:0010299)1.56456727
100Occipital encephalocele (HP:0002085)1.55629636
101Scotoma (HP:0000575)1.55209024
102Dandy-Walker malformation (HP:0001305)1.55047468
103Myokymia (HP:0002411)1.54429502
104Intellectual disability, moderate (HP:0002342)1.54283150
105Decreased circulating renin level (HP:0003351)1.54243379
106Bony spicule pigmentary retinopathy (HP:0007737)1.53449462
107Furrowed tongue (HP:0000221)1.52985303
108Facial cleft (HP:0002006)1.52521816
109Cerebral inclusion bodies (HP:0100314)1.52058522
110Exercise-induced myalgia (HP:0003738)1.51426223
111Dyschromatopsia (HP:0007641)1.51404251
112Pancreatic cysts (HP:0001737)1.50632548
113Bile duct proliferation (HP:0001408)1.50436105
114Abnormal biliary tract physiology (HP:0012439)1.50436105
115Oligodactyly (hands) (HP:0001180)1.50023735
116Specific learning disability (HP:0001328)1.49923426
117Papillary thyroid carcinoma (HP:0002895)1.49907851
118Buphthalmos (HP:0000557)1.49339317
119Lissencephaly (HP:0001339)1.46841676
120Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.46562701
121Degeneration of the lateral corticospinal tracts (HP:0002314)1.46562701
122Nephropathy (HP:0000112)1.46315502
123Hypoplasia of the brainstem (HP:0002365)1.45640696
124Aplasia/Hypoplasia of the brainstem (HP:0007362)1.45640696
125* Short ribs (HP:0000773)1.45030987
126Type II lissencephaly (HP:0007260)1.45025264
127Hyperventilation (HP:0002883)1.44908485
128Left ventricular hypertrophy (HP:0001712)1.44083683
129Astigmatism (HP:0000483)1.41869753
130Abnormality of ocular smooth pursuit (HP:0000617)1.40974924
131Neuroendocrine neoplasm (HP:0100634)1.40941545
132Pachygyria (HP:0001302)1.40051339
133Lower limb muscle weakness (HP:0007340)1.39925152
134Decreased motor nerve conduction velocity (HP:0003431)1.39430074
135Attenuation of retinal blood vessels (HP:0007843)1.39324625
136Iris coloboma (HP:0000612)1.38339479
137Median cleft lip (HP:0000161)1.38270440
138Aplasia/Hypoplasia of the spleen (HP:0010451)1.32932205
139Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.32797847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.17922194
2PDK36.17922194
3PRKD34.66391858
4PDK23.71696719
5TESK13.10070387
6NTRK32.88295214
7WNK42.69660055
8PNCK2.62934411
9PTK2B2.53968007
10ICK2.18856724
11STK392.04915830
12MAP4K21.99333673
13CASK1.91869946
14CDK191.78137552
15MET1.71432982
16MAPK151.67439704
17PLK41.67055769
18MAP3K41.64182671
19STK381.57098156
20EPHA31.56473579
21LMTK21.50547107
22ADRBK21.43857235
23TLK11.42769795
24EPHA41.39209397
25MINK11.36520045
26PLK21.33338050
27NUAK11.32679834
28WNK11.30627379
29FRK1.30320515
30WNK31.27229112
31NTRK11.22600198
32MAPK131.20592449
33SIK21.20022947
34MARK11.18969014
35TIE11.16262415
36NTRK21.16142203
37MAP2K71.15633063
38DYRK21.14824192
39SGK2231.11651510
40SGK4941.11651510
41FGFR21.09279950
42DYRK31.06261572
43CSNK1G21.05558956
44EPHB21.00769454
45MAP2K21.00454401
46GRK10.99540132
47MAP3K90.99539780
48PAK60.99203859
49PHKG10.96616191
50PHKG20.96616191
51SGK20.95858016
52CAMK1D0.90793715
53PRPF4B0.90505577
54MAP3K70.88244651
55CAMK10.86850862
56STK38L0.84886689
57CSNK1G30.83775433
58BMX0.83611614
59PRKCG0.82006575
60TYRO30.80718182
61NME10.80354234
62ZAK0.79267112
63ATR0.79117048
64VRK20.79063301
65OXSR10.77420156
66PASK0.76762110
67WEE10.76124861
68VRK10.74579155
69BCR0.74094892
70UHMK10.73580100
71PLK10.70801268
72FER0.69821233
73MAPKAPK30.66063786
74MAPKAPK50.65406033
75CDK30.65178542
76CCNB10.64584599
77CSNK1G10.64531066
78CAMK1G0.64450318
79BCKDK0.63608751
80GRK50.62325689
81CDK50.61329481
82CSF1R0.60844977
83MUSK0.60710036
84PDK10.60349068
85CAMKK10.59901636
86BMPR1B0.59891940
87STK160.59859560
88CAMK2A0.59083398
89SIK10.57643101
90SGK30.57478252
91PRKCI0.56691239
92DAPK20.56004205
93PRKCZ0.55975164
94PRKCH0.55861330
95DYRK1B0.55488868
96CDC42BPA0.55092569
97ERBB20.53604597
98TNIK0.51171508
99MARK30.50770969
100FGR0.50562925
101TSSK60.50523241
102PRKD20.50242815
103PRKCE0.49339316
104CDK180.48868704
105CDK140.48264490
106PINK10.48188435
107MARK20.46223851
108KSR10.45803402
109MAP2K40.45214711
110PAK30.44890671
111MAP2K60.44709587
112RPS6KB10.44639901
113CDK150.44509901
114RPS6KA60.44441747
115STK110.44432865
116RPS6KA20.43913505
117TRIM280.43842331
118TGFBR10.43676942
119CDK70.43675508
120BRSK20.43156708
121MAP3K20.41928049
122INSRR0.41760437
123BRSK10.40707496
124KSR20.40434819
125MKNK10.39627494
126CAMK2D0.37793201
127RIPK40.37318754
128NEK20.37318630
129AKT30.36888752
130RET0.36475057
131SGK10.34170217
132CDK11A0.32780736
133ADRBK10.31685801
134NEK60.31272290
135DYRK1A0.30844848
136ERBB30.30731319
137MAP3K120.30194206
138DAPK10.29915401
139ROCK10.29240939
140PDPK10.29152328
141CAMK2B0.28688385
142MYLK0.28036918
143MAP2K10.26797170
144DDR20.26655182
145STK30.25789898
146IRAK20.25177561
147PRKACB0.24642065
148DMPK0.24587655
149PDGFRA0.23872487
150CAMKK20.22807729
151PRKAA10.22706781
152RPS6KA30.22400127
153PRKACA0.22284140

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.68074994
2Synaptic vesicle cycle_Homo sapiens_hsa047212.45374980
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.40261462
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29146881
5Nicotine addiction_Homo sapiens_hsa050332.25785372
6Insulin secretion_Homo sapiens_hsa049112.22784491
7Amphetamine addiction_Homo sapiens_hsa050312.19872062
8Long-term potentiation_Homo sapiens_hsa047202.19224018
9Phototransduction_Homo sapiens_hsa047442.12035172
10Butanoate metabolism_Homo sapiens_hsa006502.09910161
11Circadian entrainment_Homo sapiens_hsa047132.09342383
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.09193328
13Olfactory transduction_Homo sapiens_hsa047402.02443915
14Renin secretion_Homo sapiens_hsa049241.95657122
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.93100211
16Glutamatergic synapse_Homo sapiens_hsa047241.80843514
17Cardiac muscle contraction_Homo sapiens_hsa042601.77626328
18Dorso-ventral axis formation_Homo sapiens_hsa043201.77332510
19Pyruvate metabolism_Homo sapiens_hsa006201.76782134
20Glucagon signaling pathway_Homo sapiens_hsa049221.76727865
21Collecting duct acid secretion_Homo sapiens_hsa049661.74411675
22Nitrogen metabolism_Homo sapiens_hsa009101.73476747
23Taste transduction_Homo sapiens_hsa047421.72060019
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71578752
25Fanconi anemia pathway_Homo sapiens_hsa034601.68725273
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64847615
27Dopaminergic synapse_Homo sapiens_hsa047281.61929934
28Morphine addiction_Homo sapiens_hsa050321.60838639
29Base excision repair_Homo sapiens_hsa034101.58513276
30Sulfur relay system_Homo sapiens_hsa041221.57002926
31Oocyte meiosis_Homo sapiens_hsa041141.54818172
32GABAergic synapse_Homo sapiens_hsa047271.54068951
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.50138621
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50078977
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47967293
36Salivary secretion_Homo sapiens_hsa049701.45832170
37Gastric acid secretion_Homo sapiens_hsa049711.44740516
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42567564
39Calcium signaling pathway_Homo sapiens_hsa040201.39557343
40ABC transporters_Homo sapiens_hsa020101.38692148
41beta-Alanine metabolism_Homo sapiens_hsa004101.37828647
42Huntingtons disease_Homo sapiens_hsa050161.37267242
43Estrogen signaling pathway_Homo sapiens_hsa049151.36859131
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36393991
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34617614
46Cocaine addiction_Homo sapiens_hsa050301.33848297
47Chemical carcinogenesis_Homo sapiens_hsa052041.30736967
48Cholinergic synapse_Homo sapiens_hsa047251.29720190
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28765273
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27871927
51Homologous recombination_Homo sapiens_hsa034401.27572395
52Vibrio cholerae infection_Homo sapiens_hsa051101.26017231
53Carbohydrate digestion and absorption_Homo sapiens_hsa049731.25409119
54Oxytocin signaling pathway_Homo sapiens_hsa049211.23330212
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22229222
56Tyrosine metabolism_Homo sapiens_hsa003501.21328695
57Serotonergic synapse_Homo sapiens_hsa047261.19687537
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16488509
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14878875
60Maturity onset diabetes of the young_Homo sapiens_hsa049501.11892171
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11107192
62Phenylalanine metabolism_Homo sapiens_hsa003601.08268246
63Vascular smooth muscle contraction_Homo sapiens_hsa042701.07604667
64Glycosaminoglycan degradation_Homo sapiens_hsa005311.06746698
65Fatty acid biosynthesis_Homo sapiens_hsa000611.06162578
66Histidine metabolism_Homo sapiens_hsa003401.05436361
67cAMP signaling pathway_Homo sapiens_hsa040241.04311265
68Peroxisome_Homo sapiens_hsa041461.04265677
69Tryptophan metabolism_Homo sapiens_hsa003801.02381202
70Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02263907
71Vitamin B6 metabolism_Homo sapiens_hsa007501.01846912
72GnRH signaling pathway_Homo sapiens_hsa049120.98446282
73Glutathione metabolism_Homo sapiens_hsa004800.98177064
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97855687
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97654555
76Melanogenesis_Homo sapiens_hsa049160.96528516
77Gap junction_Homo sapiens_hsa045400.96484582
78Hedgehog signaling pathway_Homo sapiens_hsa043400.96246585
79Propanoate metabolism_Homo sapiens_hsa006400.96073368
80Thyroid hormone synthesis_Homo sapiens_hsa049180.95401543
81Axon guidance_Homo sapiens_hsa043600.93756137
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93515398
83Type II diabetes mellitus_Homo sapiens_hsa049300.92068669
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.91642308
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90519574
86Alzheimers disease_Homo sapiens_hsa050100.88534404
87Notch signaling pathway_Homo sapiens_hsa043300.87834140
88Long-term depression_Homo sapiens_hsa047300.87001914
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86976506
90Dilated cardiomyopathy_Homo sapiens_hsa054140.86632517
91Pancreatic secretion_Homo sapiens_hsa049720.81783805
92Oxidative phosphorylation_Homo sapiens_hsa001900.81629782
93Regulation of autophagy_Homo sapiens_hsa041400.81149349
94Steroid biosynthesis_Homo sapiens_hsa001000.78891472
95Arachidonic acid metabolism_Homo sapiens_hsa005900.74008687
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73186470
97Lysine degradation_Homo sapiens_hsa003100.72830617
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71320995
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70849342
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69823332
101Glioma_Homo sapiens_hsa052140.69664202
102Nucleotide excision repair_Homo sapiens_hsa034200.69568222
103Wnt signaling pathway_Homo sapiens_hsa043100.68672448
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68081183
105Selenocompound metabolism_Homo sapiens_hsa004500.67156596
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66581404
107Parkinsons disease_Homo sapiens_hsa050120.65474429
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65464806
109Glycerolipid metabolism_Homo sapiens_hsa005610.64121455
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.63679578
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63442755
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63230000
113Alcoholism_Homo sapiens_hsa050340.62607823
114Fatty acid metabolism_Homo sapiens_hsa012120.61804794
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60049318
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59915403
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.59648759
118Metabolic pathways_Homo sapiens_hsa011000.59609571
119Inositol phosphate metabolism_Homo sapiens_hsa005620.56751788
120Circadian rhythm_Homo sapiens_hsa047100.56572421
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56178165
122MAPK signaling pathway_Homo sapiens_hsa040100.55937592
123Linoleic acid metabolism_Homo sapiens_hsa005910.55229292
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55067709
125Lysosome_Homo sapiens_hsa041420.54271789
126Ovarian steroidogenesis_Homo sapiens_hsa049130.53885348
127Fatty acid degradation_Homo sapiens_hsa000710.53382687
128Retinol metabolism_Homo sapiens_hsa008300.52858882
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.52590180
130VEGF signaling pathway_Homo sapiens_hsa043700.52497146
131Hippo signaling pathway_Homo sapiens_hsa043900.51967805
132Mismatch repair_Homo sapiens_hsa034300.51792806
133Tight junction_Homo sapiens_hsa045300.49734079
134Mineral absorption_Homo sapiens_hsa049780.49724867
135Insulin signaling pathway_Homo sapiens_hsa049100.49125683
136Purine metabolism_Homo sapiens_hsa002300.48958408
137Sphingolipid metabolism_Homo sapiens_hsa006000.48782745
138ErbB signaling pathway_Homo sapiens_hsa040120.47933049
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.46885311
140Endocytosis_Homo sapiens_hsa041440.45144955
141Ether lipid metabolism_Homo sapiens_hsa005650.43742523
142Choline metabolism in cancer_Homo sapiens_hsa052310.43484150
143Protein digestion and absorption_Homo sapiens_hsa049740.42547478
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42258668
145Basal transcription factors_Homo sapiens_hsa030220.40638095
146N-Glycan biosynthesis_Homo sapiens_hsa005100.40500893
147Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40422336
148Basal cell carcinoma_Homo sapiens_hsa052170.39018479

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