IFT140

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.85564160
2acrosome assembly (GO:0001675)9.80985997
3multicellular organism reproduction (GO:0032504)9.38152748
4binding of sperm to zona pellucida (GO:0007339)9.25159891
5acrosome reaction (GO:0007340)9.10696088
6cell-cell recognition (GO:0009988)9.05837129
7plasma membrane fusion (GO:0045026)8.97779987
8motile cilium assembly (GO:0044458)8.79011998
9male meiosis (GO:0007140)8.64378208
10epithelial cilium movement (GO:0003351)8.61100414
11cell wall macromolecule catabolic process (GO:0016998)8.33488954
12cell wall macromolecule metabolic process (GO:0044036)8.33488954
13spermatid development (GO:0007286)8.31860479
14synaptonemal complex organization (GO:0070193)8.07249038
15synaptonemal complex assembly (GO:0007130)7.82611627
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.74673278
17reproduction (GO:0000003)7.64634042
18cilium movement (GO:0003341)7.61564594
19regulation of cilium movement (GO:0003352)6.89897846
20DNA methylation involved in gamete generation (GO:0043046)6.43532691
21single fertilization (GO:0007338)6.35289755
22male meiosis I (GO:0007141)6.02210130
23sperm capacitation (GO:0048240)5.89909244
24negative regulation of inclusion body assembly (GO:0090084)5.71012890
25fertilization (GO:0009566)5.67741180
26chromosome organization involved in meiosis (GO:0070192)5.57783252
27spermatogenesis (GO:0007283)5.48549882
28male gamete generation (GO:0048232)5.46853154
29meiotic nuclear division (GO:0007126)5.42424786
30ventricular system development (GO:0021591)5.13539525
31meiosis I (GO:0007127)5.09333622
32gamete generation (GO:0007276)5.02221301
33seminiferous tubule development (GO:0072520)5.00137985
34germ cell development (GO:0007281)4.98575399
35cellular process involved in reproduction in multicellular organism (GO:0022412)4.98240797
36microtubule depolymerization (GO:0007019)4.80074484
37planar cell polarity pathway involved in neural tube closure (GO:0090179)4.74567882
38meiotic cell cycle (GO:0051321)4.72794416
39gene silencing by RNA (GO:0031047)4.67080369
40establishment of apical/basal cell polarity (GO:0035089)4.65681794
41regulation of inclusion body assembly (GO:0090083)4.56985135
42lung epithelium development (GO:0060428)4.44580132
43regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.41075985
44monoubiquitinated protein deubiquitination (GO:0035520)4.32774491
45organic cation transport (GO:0015695)4.30138844
46microtubule severing (GO:0051013)4.23901375
47cell recognition (GO:0008037)4.22732035
48establishment or maintenance of monopolar cell polarity (GO:0061339)4.15396636
49establishment of monopolar cell polarity (GO:0061162)4.15396636
50regulation of microtubule-based movement (GO:0060632)4.14861423
51nuclear pore complex assembly (GO:0051292)4.02647532
52microtubule bundle formation (GO:0001578)4.00295324
53calcium ion-dependent exocytosis (GO:0017156)3.94891032
54establishment of planar polarity (GO:0001736)3.93948095
55establishment of tissue polarity (GO:0007164)3.93948095
56multicellular organismal reproductive process (GO:0048609)3.93690991
57mitotic sister chromatid cohesion (GO:0007064)3.93664946
58apical protein localization (GO:0045176)3.89491455
59genitalia morphogenesis (GO:0035112)3.87723403
60primary alcohol catabolic process (GO:0034310)3.85444865
61left/right pattern formation (GO:0060972)3.81879434
62left/right axis specification (GO:0070986)3.81049657
63chromosome condensation (GO:0030261)3.74205772
64regulation of centriole replication (GO:0046599)3.72718242
65negative regulation of organelle assembly (GO:1902116)3.68092602
66DNA packaging (GO:0006323)3.67287625
67meiotic cell cycle process (GO:1903046)3.64027718
68chaperone-mediated protein complex assembly (GO:0051131)3.62146676
69regulation of histone H3-K9 methylation (GO:0051570)3.55384070
70camera-type eye morphogenesis (GO:0048593)3.54965984
71vitamin transmembrane transport (GO:0035461)3.52713425
72gene silencing (GO:0016458)3.51153399
73translesion synthesis (GO:0019985)3.48441330
74dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.44986375
75lateral sprouting from an epithelium (GO:0060601)3.43191081
76protein polyglutamylation (GO:0018095)3.42414251
77regulation of meiosis I (GO:0060631)3.37554655
78nuclear pore organization (GO:0006999)3.37195159
79positive regulation of smoothened signaling pathway (GO:0045880)3.34361007
80glomerular epithelial cell development (GO:0072310)3.32334657
81establishment or maintenance of bipolar cell polarity (GO:0061245)3.28961380
82establishment or maintenance of apical/basal cell polarity (GO:0035088)3.28961380
83synapsis (GO:0007129)3.28792718
84Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.27789868
85* intraciliary transport (GO:0042073)3.25485026
86ethanol metabolic process (GO:0006067)3.23285184
87regulation of protein polyubiquitination (GO:1902914)3.22001693
88asymmetric protein localization (GO:0008105)3.20451483
89* cilium assembly (GO:0042384)3.19038104
90multicellular organismal development (GO:0007275)3.16969263
91negative regulation of DNA repair (GO:0045738)3.16769039
92regulation of establishment of planar polarity (GO:0090175)3.13785148
93axoneme assembly (GO:0035082)3.13601993
94semaphorin-plexin signaling pathway (GO:0071526)3.12196014
95spermatid nucleus differentiation (GO:0007289)3.09993082
96cytoskeletal anchoring at plasma membrane (GO:0007016)3.09342403
97regulation of spindle checkpoint (GO:0090231)3.09084665
98pore complex assembly (GO:0046931)3.05542468
99carnitine transmembrane transport (GO:1902603)3.04370685
100carnitine transport (GO:0015879)3.02431819
101amino-acid betaine transport (GO:0015838)3.02431819
102* microtubule-based movement (GO:0007018)3.01569256
103protein localization to chromosome, centromeric region (GO:0071459)3.01434209
104ear development (GO:0043583)2.98669973
105DNA replication-dependent nucleosome organization (GO:0034723)2.97064988
106DNA replication-dependent nucleosome assembly (GO:0006335)2.97064988
107regulation of chromatin binding (GO:0035561)2.96286308
108DNA alkylation (GO:0006305)2.96200763
109DNA methylation (GO:0006306)2.96200763
110embryonic camera-type eye development (GO:0031076)2.96066442
111nucleus organization (GO:0006997)2.95451185
112lactate metabolic process (GO:0006089)2.93508586
113glycerol ether metabolic process (GO:0006662)2.92923508
114centriole replication (GO:0007099)2.90166757
115neuron projection extension involved in neuron projection guidance (GO:1902284)2.86797505
116axon extension involved in axon guidance (GO:0048846)2.86797505
117protein-DNA complex disassembly (GO:0032986)2.85493960
118nucleosome disassembly (GO:0006337)2.85493960
119sister chromatid cohesion (GO:0007062)2.85043118
120convergent extension (GO:0060026)2.83663746
121centriole assembly (GO:0098534)2.82778453
122G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.82499754
123paraxial mesoderm development (GO:0048339)2.79390043
124protein refolding (GO:0042026)2.76396928
125RNA localization (GO:0006403)2.74423821
126ether metabolic process (GO:0018904)2.69361454
127establishment of nucleus localization (GO:0040023)2.64746278
128cell-cell junction maintenance (GO:0045217)2.62964544
129protein retention in ER lumen (GO:0006621)2.62458295
130peptidyl-lysine dimethylation (GO:0018027)2.60362426
131histone exchange (GO:0043486)2.58180422
132* cellular component assembly involved in morphogenesis (GO:0010927)2.56785232
133non-canonical Wnt signaling pathway (GO:0035567)2.55361421
134glycolytic process (GO:0006096)2.53652491
135* cilium organization (GO:0044782)2.51929929
136regulation of smoothened signaling pathway (GO:0008589)2.50610600
137lateral ventricle development (GO:0021670)2.49848170
138eye morphogenesis (GO:0048592)2.47757858
139layer formation in cerebral cortex (GO:0021819)2.47214745
140peptidyl-tyrosine autophosphorylation (GO:0038083)2.44537995
141negative regulation of chondrocyte differentiation (GO:0032331)2.44364716
142neural tube closure (GO:0001843)2.40110930
143cell migration in hindbrain (GO:0021535)2.40101410
144embryonic retina morphogenesis in camera-type eye (GO:0060059)2.39547699
145regulation of interleukin-5 production (GO:0032674)2.39242152
146tube closure (GO:0060606)2.38802521
147retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.38369938
148cochlea morphogenesis (GO:0090103)2.37587645
149cranial nerve morphogenesis (GO:0021602)2.37098233
150ethanol oxidation (GO:0006069)2.36640314
151maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.36303075
152regulation of microtubule depolymerization (GO:0031114)2.35991819
153* cell projection assembly (GO:0030031)2.34439736
154COPI coating of Golgi vesicle (GO:0048205)2.33234248
155Golgi transport vesicle coating (GO:0048200)2.33234248
156body morphogenesis (GO:0010171)2.32564817
157establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.32384663
158vocalization behavior (GO:0071625)2.31860009
159one-carbon compound transport (GO:0019755)2.31822080
160regulation of interleukin-13 production (GO:0032656)2.30229821
161cerebellar granule cell differentiation (GO:0021707)2.29852931
162positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.28064930
163embryonic body morphogenesis (GO:0010172)2.24381631
164negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.22577049
165cilium morphogenesis (GO:0060271)2.20053207
166regulation of response to osmotic stress (GO:0047484)2.18750183
167neuronal ion channel clustering (GO:0045161)2.15529760
168epithelial cell-cell adhesion (GO:0090136)2.15175342
169cytoplasmic microtubule organization (GO:0031122)2.15059267
170epithelial cell differentiation involved in prostate gland development (GO:0060742)2.14991909
171regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.14499789
172appendage development (GO:0048736)2.14230757
173limb development (GO:0060173)2.14230757
174endothelial cell chemotaxis (GO:0035767)2.12836509
175negative regulation of microtubule depolymerization (GO:0007026)2.10216788
176lens morphogenesis in camera-type eye (GO:0002089)2.10163714
177cilium or flagellum-dependent cell motility (GO:0001539)13.9439405
178fusion of sperm to egg plasma membrane (GO:0007342)11.8506134
179sperm motility (GO:0030317)10.6359752
180piRNA metabolic process (GO:0034587)10.3529163
181sperm-egg recognition (GO:0035036)10.0229924

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.81489844
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.19361285
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.93685094
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.20445982
5DROSHA_22980978_ChIP-Seq_HELA_Human2.92718962
6* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.78108927
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.70226603
8* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.69179158
9E2F7_22180533_ChIP-Seq_HELA_Human2.61470333
10TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.38211713
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38199576
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.36739924
13LXR_22292898_ChIP-Seq_THP-1_Human2.30645684
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.30428562
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25719215
16ERG_21242973_ChIP-ChIP_JURKAT_Human2.22334913
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.12988701
18GATA1_26923725_Chip-Seq_HPCs_Mouse2.12426660
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10470972
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.09277997
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.09271579
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.08049270
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05559324
24ZFP281_18757296_ChIP-ChIP_E14_Mouse2.03482031
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse12.2902345
26* KDM2B_26808549_Chip-Seq_K562_Human1.98008483
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95775180
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.94856377
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.92786895
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92606388
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.91852828
32* RACK7_27058665_Chip-Seq_MCF-7_Human1.89539696
33RUNX1_27514584_Chip-Seq_MCF-7_Human1.87760840
34CTCF_27219007_Chip-Seq_Bcells_Human1.86133604
35ZNF274_21170338_ChIP-Seq_K562_Hela1.82895369
36ELK4_26923725_Chip-Seq_MESODERM_Mouse1.81417610
37* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.81376294
38EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.80659897
39ZNF263_19887448_ChIP-Seq_K562_Human1.68568248
40FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68474125
41CREB1_26743006_Chip-Seq_LNCaP_Human1.66107632
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.64429169
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.63217186
44P68_20966046_ChIP-Seq_HELA_Human1.62824767
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62641098
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.61951191
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57658976
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.55826455
49CLOCK_20551151_ChIP-Seq_293T_Human1.51737505
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49907237
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49370578
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48139522
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.46037980
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44291033
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44291033
56OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.43622733
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.43407963
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41606321
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40710522
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40123460
61* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38736233
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38455795
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37610637
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.35833982
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.34381986
66TP53_22127205_ChIP-Seq_IMR90_Human1.34025375
67* ELK3_25401928_ChIP-Seq_HUVEC_Human1.33351573
68* KDM2B_26808549_Chip-Seq_DND41_Human1.31286652
69* TP63_22573176_ChIP-Seq_HFKS_Human1.29053119
70TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.28514529
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27111516
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26548467
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26207958
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23826190
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23055839
76GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.22751835
77FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22365725
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21996970
79TET1_21490601_ChIP-Seq_MESCs_Mouse1.21457807
80TP53_23651856_ChIP-Seq_MEFs_Mouse1.21333882
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21023127
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20838927
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.20648165
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.20348370
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19719409
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18145520
87GATA3_21867929_ChIP-Seq_CD8_Mouse1.17514197
88* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17387838
89SOX2_22085726_ChIP-Seq_NPCs_Mouse1.17230972
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.17043450
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.16253492
92E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16107911
93RARB_27405468_Chip-Seq_BRAIN_Mouse1.15590333
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15285060
95CBP_20019798_ChIP-Seq_JUKART_Human1.15285060
96KLF5_25053715_ChIP-Seq_YYC3_Human1.13561218
97CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13414992
98SOX3_22085726_ChIP-Seq_NPCs_Mouse1.12879372
99P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12464506
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.12015229
101* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11614654
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11525936
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10758927
104TCF7_22412390_ChIP-Seq_EML_Mouse1.10686927
105STAT1_17558387_ChIP-Seq_HELA_Human1.10438844
106* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10081819
107MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09646802
108TP53_20018659_ChIP-ChIP_R1E_Mouse1.08092280
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08040301
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07414259
111AHR_22903824_ChIP-Seq_MCF-7_Human1.07378294
112RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07211414
113EZH2_27304074_Chip-Seq_ESCs_Mouse1.06691475
114* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06168747
115P53_21459846_ChIP-Seq_SAOS-2_Human1.05885241
116SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05721110
117SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04194295
118YY1_22570637_ChIP-Seq_MALME-3M_Human1.03255966
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02015262
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01989573
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01954100
122LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.01828542
123RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99972561
124KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99529171
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99416762
126PHF8_20622854_ChIP-Seq_HELA_Human0.99023145
127ISL1_27105846_Chip-Seq_CPCs_Mouse0.98773103
128EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97019129
129VDR_21846776_ChIP-Seq_THP-1_Human0.96849631
130JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96220188
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95400630
132RING1B_27294783_Chip-Seq_NPCs_Mouse0.94953576
133SOX2_21211035_ChIP-Seq_LN229_Human0.93871196
134* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93561838
135SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93522549
136PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93193753
137MYB_26560356_Chip-Seq_TH1_Human0.92611324
138SPI1_20517297_ChIP-Seq_HL60_Human0.90848946
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90711122
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90711122
141GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89557951
142RARA_24833708_ChIP-Seq_LIVER_Mouse0.89032946
143SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.88843723
144SPI1_26923725_Chip-Seq_HPCs_Mouse0.88692845
145CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88159708
146FLI1_21867929_ChIP-Seq_CD8_Mouse0.86991082
147PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86947826
148ETS1_22383799_ChIP-Seq_G1ME_Mouse0.86552192
149* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85667063
150E2F1_20622854_ChIP-Seq_HELA_Human0.85248563
151BCOR_27268052_Chip-Seq_Bcells_Human0.84923729
152GATA3_26560356_Chip-Seq_TH1_Human0.84563909
153ERG_20517297_ChIP-Seq_VCAP_Human0.84397084
154KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.84318117
155RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84057782
156MYB_26560356_Chip-Seq_TH2_Human0.83869591
157KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83788887
158LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83464441
159ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.82208319
160CTCF_26484167_Chip-Seq_Bcells_Mouse0.82152198
161CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81705832
162SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81656276
163GF1_26923725_Chip-Seq_HPCs_Mouse0.81446300
164FLI1_21867929_ChIP-Seq_TH2_Mouse0.81164242
165MYC_27129775_Chip-Seq_CORNEA_Mouse0.80438291
166PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80374997
167NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.80307494
168PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79806071
169RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79133030
170KDM2B_26808549_Chip-Seq_REH_Human0.79037634
171TAL1_26923725_Chip-Seq_HPCs_Mouse0.79032797
172MYC_22102868_ChIP-Seq_BL_Human0.78600153
173SCL_19346495_ChIP-Seq_HPC-7_Human0.78499981
174TET1_21451524_ChIP-Seq_MESCs_Mouse0.78318874
175PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.78013907
176GATA3_21867929_ChIP-Seq_TH1_Mouse0.76582574
177* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.76180584
178SMC4_20622854_ChIP-Seq_HELA_Human0.75910155
179TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.75297013
180REST_21632747_ChIP-Seq_MESCs_Mouse0.74973119
181* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.74597315
182RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.74280847
183NFIB_24661679_ChIP-Seq_LUNG_Mouse0.74110276
184BCL6_27268052_Chip-Seq_Bcells_Human0.74083257
185NFE2_27457419_Chip-Seq_LIVER_Mouse0.73103262

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.48950629
2MP0003698_abnormal_male_reproductive5.40634630
3MP0001929_abnormal_gametogenesis5.13631128
4MP0002210_abnormal_sex_determination3.69171130
5MP0000566_synostosis3.59152112
6MP0002653_abnormal_ependyma_morphology3.38177791
7MP0010030_abnormal_orbit_morphology3.32570633
8MP0001145_abnormal_male_reproductive3.14950316
9MP0002161_abnormal_fertility/fecundity2.96452369
10MP0000653_abnormal_sex_gland2.70313487
11MP0008057_abnormal_DNA_replication2.67996322
12MP0002249_abnormal_larynx_morphology2.60952677
13MP0010094_abnormal_chromosome_stability2.31697613
14MP0009780_abnormal_chondrocyte_physiolo2.27802955
15MP0004859_abnormal_synaptic_plasticity2.20904404
16MP0004133_heterotaxia2.18995879
17MP0003705_abnormal_hypodermis_morpholog2.17599915
18MP0005394_taste/olfaction_phenotype2.14435780
19MP0005499_abnormal_olfactory_system2.14435780
20MP0004858_abnormal_nervous_system2.10677351
21MP0008789_abnormal_olfactory_epithelium2.07377415
22MP0001849_ear_inflammation2.03703063
23MP0000537_abnormal_urethra_morphology2.00476602
24MP0005410_abnormal_fertilization13.2348545
25MP0000569_abnormal_digit_pigmentation1.89804121
26MP0005248_abnormal_Harderian_gland1.85683218
27MP0003111_abnormal_nucleus_morphology1.84546751
28MP0005623_abnormal_meninges_morphology1.77820476
29MP0002160_abnormal_reproductive_system1.73867285
30MP0005409_darkened_coat_color1.72848128
31MP0008058_abnormal_DNA_repair1.70904828
32MP0000778_abnormal_nervous_system1.70636704
33MP0003942_abnormal_urinary_system1.66768436
34MP0008875_abnormal_xenobiotic_pharmacok1.55371993
35MP0008007_abnormal_cellular_replicative1.50711001
36MP0001346_abnormal_lacrimal_gland1.50010936
37MP0005670_abnormal_white_adipose1.49450536
38MP0000534_abnormal_ureter_morphology1.49387981
39MP0004272_abnormal_basement_membrane1.47620062
40MP0001299_abnormal_eye_distance/1.46774847
41MP0000049_abnormal_middle_ear1.46321365
42MP0004808_abnormal_hematopoietic_stem1.44121725
43MP0002233_abnormal_nose_morphology1.42659980
44MP0005503_abnormal_tendon_morphology1.40847575
45MP0009384_cardiac_valve_regurgitation1.40414197
46MP0002116_abnormal_craniofacial_bone1.37636859
47MP0001545_abnormal_hematopoietic_system1.35424100
48MP0005397_hematopoietic_system_phenotyp1.35424100
49MP0000678_abnormal_parathyroid_gland1.35295560
50MP0003077_abnormal_cell_cycle1.35085375
51MP0000383_abnormal_hair_follicle1.33582935
52MP0001958_emphysema1.26778404
53MP0005423_abnormal_somatic_nervous1.26236750
54MP0005257_abnormal_intraocular_pressure1.24409615
55MP0002822_catalepsy1.23663059
56MP0003937_abnormal_limbs/digits/tail_de1.23420398
57MP0002282_abnormal_trachea_morphology1.23135550
58MP0008995_early_reproductive_senescence1.21722275
59MP0003938_abnormal_ear_development1.20749927
60MP0000579_abnormal_nail_morphology1.20446736
61MP0004233_abnormal_muscle_weight1.20117172
62MP0000955_abnormal_spinal_cord1.19699277
63MP0002697_abnormal_eye_size1.19640435
64MP0003136_yellow_coat_color1.18617488
65MP0002132_abnormal_respiratory_system1.16036866
66MP0010307_abnormal_tumor_latency1.14731261
67MP0003122_maternal_imprinting1.14642107
68MP0000751_myopathy1.14532749
69MP0009278_abnormal_bone_marrow1.11438029
70MP0002932_abnormal_joint_morphology1.10121406
71MP0005076_abnormal_cell_differentiation1.09982508
72MP0008438_abnormal_cutaneous_collagen1.09759732
73MP0005647_abnormal_sex_gland1.07646061
74MP0004043_abnormal_pH_regulation1.07509236
75MP0003385_abnormal_body_wall1.07414910
76MP0000428_abnormal_craniofacial_morphol1.07410972
77MP0002734_abnormal_mechanical_nocicepti1.06922320
78MP0000026_abnormal_inner_ear1.06701163
79MP0010678_abnormal_skin_adnexa1.06682894
80MP0003786_premature_aging1.06094479
81MP0009053_abnormal_anal_canal1.04440683
82MP0002896_abnormal_bone_mineralization1.04138319
83MP0005508_abnormal_skeleton_morphology1.04025394
84MP0001502_abnormal_circadian_rhythm1.03709670
85MP0002152_abnormal_brain_morphology1.01324606
86MP0003656_abnormal_erythrocyte_physiolo1.00501406
87MP0002735_abnormal_chemical_nociception0.99712071
88MP0001730_embryonic_growth_arrest0.97559542
89MP0002909_abnormal_adrenal_gland0.95898907
90MP0000432_abnormal_head_morphology0.94394781
91MP0003115_abnormal_respiratory_system0.93630293
92MP0003634_abnormal_glial_cell0.93180983
93MP0002111_abnormal_tail_morphology0.91976514
94MP0002089_abnormal_postnatal_growth/wei0.91770119
95MP0005171_absent_coat_pigmentation0.91125797
96MP0010352_gastrointestinal_tract_polyps0.90530320
97MP0000685_abnormal_immune_system0.90355318
98MP0002108_abnormal_muscle_morphology0.90154145
99MP0005389_reproductive_system_phenotype0.90087322
100MP0010234_abnormal_vibrissa_follicle0.89949951
101MP0000762_abnormal_tongue_morphology0.88616346
102MP0002098_abnormal_vibrissa_morphology0.88513397
103MP0000681_abnormal_thyroid_gland0.87153342
104MP0003119_abnormal_digestive_system0.85335116
105MP0003935_abnormal_craniofacial_develop0.85303613
106MP0001984_abnormal_olfaction0.85283617
107MP0003646_muscle_fatigue0.84300059
108MP0003755_abnormal_palate_morphology0.83895142
109MP0000733_abnormal_muscle_development0.83769705
110MP0002184_abnormal_innervation0.83162532
111MP0004270_analgesia0.83129011
112MP0000358_abnormal_cell_content/0.82503033
113MP0003566_abnormal_cell_adhesion0.81988314
114MP0000467_abnormal_esophagus_morphology0.81725635
115MP0002882_abnormal_neuron_morphology0.80727989
116MP0003091_abnormal_cell_migration0.78989835
117MP0000003_abnormal_adipose_tissue0.78354428
118MP0005083_abnormal_biliary_tract0.78009176
119MP0003283_abnormal_digestive_organ0.77926724
120MP0008961_abnormal_basal_metabolism0.77116442
121MP0003693_abnormal_embryo_hatching0.76743937
122MP0002398_abnormal_bone_marrow0.74337290
123MP0000313_abnormal_cell_death0.74161918
124MP0002928_abnormal_bile_duct0.73190302
125MP0004782_abnormal_surfactant_physiolog0.72672754
126MP0010368_abnormal_lymphatic_system0.72287747
127MP0002081_perinatal_lethality0.71111760
128MP0002114_abnormal_axial_skeleton0.70823441
129MP0003635_abnormal_synaptic_transmissio0.69963525
130MP0003011_delayed_dark_adaptation0.61843045
131MP0000350_abnormal_cell_proliferation0.61176752
132MP0002234_abnormal_pharynx_morphology0.61165931
133MP0001765_abnormal_ion_homeostasis0.60924708
134MP0002084_abnormal_developmental_patter0.60660924
135MP0004147_increased_porphyrin_level0.60641477
136MP0003300_gastrointestinal_ulcer0.60399481
137MP0000703_abnormal_thymus_morphology0.60314140
138MP0001293_anophthalmia0.59521888
139MP0003763_abnormal_thymus_physiology0.59157899
140MP0001697_abnormal_embryo_size0.57856265
141MP0003699_abnormal_female_reproductive0.57283308
142MP0002080_prenatal_lethality0.57273355
143MP0001835_abnormal_antigen_presentation0.56608498
144MP0003787_abnormal_imprinting0.56427292
145MP0000689_abnormal_spleen_morphology0.55359972
146MP0005380_embryogenesis_phenotype0.54982715
147MP0001672_abnormal_embryogenesis/_devel0.54982715
148MP0003045_fibrosis0.54398878
149MP0004957_abnormal_blastocyst_morpholog0.52423462
150MP0009046_muscle_twitch0.51909689
151MP0001800_abnormal_humoral_immune0.51629327
152MP0004197_abnormal_fetal_growth/weight/0.51552681
153MP0002405_respiratory_system_inflammati0.51394274
154MP0004134_abnormal_chest_morphology0.51181251
155MP0003984_embryonic_growth_retardation0.50446555
156MP0005666_abnormal_adipose_tissue0.50293795
157MP0001873_stomach_inflammation0.50054141
158MP0002019_abnormal_tumor_incidence0.47125458
159MP0002088_abnormal_embryonic_growth/wei0.47043055
160MP0002092_abnormal_eye_morphology0.46922988
161MP0001119_abnormal_female_reproductive0.46408367
162MP0003329_amyloid_beta_deposits0.45947192
163MP0003943_abnormal_hepatobiliary_system0.44967712
164MP0002722_abnormal_immune_system0.44562101
165MP0003878_abnormal_ear_physiology0.44421774
166MP0005377_hearing/vestibular/ear_phenot0.44421774
167MP0002429_abnormal_blood_cell0.43921181
168MP0002085_abnormal_embryonic_tissue0.41734004
169MP0005174_abnormal_tail_pigmentation0.41021508
170MP0000716_abnormal_immune_system0.40845489
171MP0003861_abnormal_nervous_system0.39737842
172MP0005391_vision/eye_phenotype0.39381627
173MP0002396_abnormal_hematopoietic_system0.37119397
174MP0002086_abnormal_extraembryonic_tissu0.36995575
175MP0006054_spinal_hemorrhage0.32737259
176MP0008770_decreased_survivor_rate0.32511674
177MP0001790_abnormal_immune_system0.32423488
178MP0005387_immune_system_phenotype0.32423488
179MP0005384_cellular_phenotype0.32358633
180MP0009703_decreased_birth_body0.32232760
181MP0005636_abnormal_mineral_homeostasis0.31953143
182MP0000604_amyloidosis0.30794302
183MP0003866_abnormal_defecation0.30688747
184MP0002452_abnormal_antigen_presenting0.30558880
185MP0002166_altered_tumor_susceptibility0.30026071

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.55829697
2Abnormal respiratory motile cilium morphology (HP:0005938)8.02691006
3Abnormal respiratory epithelium morphology (HP:0012253)8.02691006
4Rhinitis (HP:0012384)7.68543311
5Chronic bronchitis (HP:0004469)7.06466236
6Nasal polyposis (HP:0100582)6.75540461
7Abnormal ciliary motility (HP:0012262)6.62726064
8Infertility (HP:0000789)6.06876185
9Abnormality of the nasal mucosa (HP:0000433)5.51718934
10Bronchitis (HP:0012387)4.97258429
11Bronchiectasis (HP:0002110)4.84118288
12Abnormality of the lower motor neuron (HP:0002366)4.00906848
13Recurrent sinusitis (HP:0011108)3.84500454
14Recurrent otitis media (HP:0000403)3.74169929
15Recurrent bronchitis (HP:0002837)3.57786557
16Atelectasis (HP:0100750)3.44770120
17Occipital encephalocele (HP:0002085)3.42235505
18Male infertility (HP:0003251)3.41453387
19Gonadotropin excess (HP:0000837)3.35171291
20* Nephronophthisis (HP:0000090)3.32786560
21Abnormal spermatogenesis (HP:0008669)3.10221201
22Amyotrophic lateral sclerosis (HP:0007354)3.08532758
23Impulsivity (HP:0100710)2.62480443
24Fibular hypoplasia (HP:0003038)2.57040226
25Heterotopia (HP:0002282)2.55581952
26Tubular atrophy (HP:0000092)2.48324115
27* Abnormality of the renal medulla (HP:0100957)2.48096327
28Obstructive sleep apnea (HP:0002870)2.47809001
29Abnormality of midbrain morphology (HP:0002418)2.47602331
30Molar tooth sign on MRI (HP:0002419)2.47602331
31Tubulointerstitial nephritis (HP:0001970)2.46784137
32Azoospermia (HP:0000027)2.43221599
33Tubulointerstitial abnormality (HP:0001969)2.23508366
34Absent frontal sinuses (HP:0002688)2.21504167
35Chronic sinusitis (HP:0011109)2.20353795
36Impaired proprioception (HP:0010831)2.19008707
37Medial flaring of the eyebrow (HP:0010747)2.14711327
38Bronchomalacia (HP:0002780)2.13138696
39Abnormality of the anterior horn cell (HP:0006802)2.11850329
40Degeneration of anterior horn cells (HP:0002398)2.11850329
41True hermaphroditism (HP:0010459)2.08369672
42Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.07807778
43Upper motor neuron abnormality (HP:0002127)2.07127214
44Hand muscle atrophy (HP:0009130)2.05274738
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5956730
46Absent/shortened dynein arms (HP:0200106)11.3819639
47Dynein arm defect of respiratory motile cilia (HP:0012255)11.3819639
48Flat acetabular roof (HP:0003180)1.99142902
49Cervical subluxation (HP:0003308)1.98826838
50Pancreatic fibrosis (HP:0100732)1.98351341
51Ulnar bowing (HP:0003031)1.98170972
52Turricephaly (HP:0000262)1.97350007
5311 pairs of ribs (HP:0000878)1.97023791
54Protrusio acetabuli (HP:0003179)1.93613861
55Abnormality of the aortic arch (HP:0012303)1.89903611
56Vertebral arch anomaly (HP:0008438)1.89817090
57Upper limb amyotrophy (HP:0009129)1.86242245
58Distal upper limb amyotrophy (HP:0007149)1.86242245
59Tubulointerstitial fibrosis (HP:0005576)1.85843932
60Chronic hepatic failure (HP:0100626)1.84515232
61Selective tooth agenesis (HP:0001592)1.79795918
62Abnormality of ocular smooth pursuit (HP:0000617)1.79027909
63Shallow orbits (HP:0000586)1.78768685
64Hyperactive renin-angiotensin system (HP:0000841)1.77173466
65Aplasia involving bones of the extremities (HP:0009825)1.76872003
66Aplasia involving bones of the upper limbs (HP:0009823)1.76872003
67Aplasia of the phalanges of the hand (HP:0009802)1.76872003
68Abnormal gallbladder physiology (HP:0012438)1.73946883
69Cholecystitis (HP:0001082)1.73946883
70Deformed sella turcica (HP:0002681)1.71874897
71Congenital hepatic fibrosis (HP:0002612)1.71259473
72Short nail (HP:0001799)1.69747360
73Broad face (HP:0000283)1.69721614
74Supernumerary spleens (HP:0009799)1.67182034
75Broad distal phalanx of finger (HP:0009836)1.66918392
76Broad metatarsal (HP:0001783)1.66111007
77Oculomotor apraxia (HP:0000657)1.65069138
78Abnormality of the distal phalanges of the toes (HP:0010182)1.64945678
79Spastic tetraparesis (HP:0001285)1.64113044
80Renovascular hypertension (HP:0100817)1.63117659
81Truncal obesity (HP:0001956)1.60889623
82Cutaneous finger syndactyly (HP:0010554)1.59803207
83Anencephaly (HP:0002323)1.58705097
84J-shaped sella turcica (HP:0002680)1.58388868
85Neonatal short-limb short stature (HP:0008921)1.57989478
86High pitched voice (HP:0001620)1.57420737
87Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.56345779
88Abnormality of the renal cortex (HP:0011035)1.56185815
89Facial cleft (HP:0002006)1.54555401
90Bifid scrotum (HP:0000048)1.51660042
91Cerebellar dysplasia (HP:0007033)1.51595894
92Polydipsia (HP:0001959)1.51294450
93Abnormal drinking behavior (HP:0030082)1.51294450
94Polycystic kidney dysplasia (HP:0000113)1.50860625
95Microglossia (HP:0000171)1.50474379
96Abnormality of dentin (HP:0010299)1.50184614
97Flattened epiphyses (HP:0003071)1.48997550
98Insomnia (HP:0100785)1.48571953
99Cutaneous syndactyly (HP:0012725)1.47574400
100Aplasia/Hypoplasia of the fibula (HP:0006492)1.47463826
101Morphological abnormality of the middle ear (HP:0008609)1.47198568
102Down-sloping shoulders (HP:0200021)1.46673323
103Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.45516283
104Arterial tortuosity (HP:0005116)1.44266663
105Arnold-Chiari malformation (HP:0002308)1.43657573
106Broad palm (HP:0001169)1.43561255
107Sloping forehead (HP:0000340)1.42957288
108Conjunctival telangiectasia (HP:0000524)1.42594112
109Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.42411947
110Partial duplication of thumb phalanx (HP:0009944)1.40589025
111Gait imbalance (HP:0002141)1.40255219
112Vascular tortuosity (HP:0004948)1.40093876
113Prominent nose (HP:0000448)1.39940234
114Abnormality of permanent molar morphology (HP:0011071)1.39712766
115Abnormality of the dental root (HP:0006486)1.39712766
116Taurodontia (HP:0000679)1.39712766
117* Postaxial foot polydactyly (HP:0001830)1.39676747
118Hyperacusis (HP:0010780)1.39407157
119Ectopic kidney (HP:0000086)1.37805798
120* Short ribs (HP:0000773)1.37158350
121Pachygyria (HP:0001302)1.37013096
122Broad finger (HP:0001500)1.36254477
123Abnormality of the epiphyses of the hand (HP:0005924)1.35876437
124Abnormal biliary tract physiology (HP:0012439)1.35598129
125Bile duct proliferation (HP:0001408)1.35598129
126Broad phalanges of the hand (HP:0009768)1.35002099
127Coronal craniosynostosis (HP:0004440)1.34974309
128Breast carcinoma (HP:0003002)1.34632377
129Sleep apnea (HP:0010535)1.34212483
130Decreased motor nerve conduction velocity (HP:0003431)1.33982624
131Abnormality of the distal phalanx of the thumb (HP:0009617)1.33260505
132Large eyes (HP:0001090)1.33117206
133Cystic liver disease (HP:0006706)1.33114009
134High anterior hairline (HP:0009890)1.32990418
135Median cleft lip (HP:0000161)1.32791716
136Preaxial hand polydactyly (HP:0001177)1.31946139
137Precocious puberty (HP:0000826)1.31835195
138Poikilocytosis (HP:0004447)1.31553441
139Trigonocephaly (HP:0000243)1.31027097
140Choanal stenosis (HP:0000452)1.30149729
141Congenital primary aphakia (HP:0007707)1.29938748
142* Short thorax (HP:0010306)1.27342173
143Neoplasm of the heart (HP:0100544)1.26389290
144Nuclear cataract (HP:0100018)1.26295324
145Bladder diverticulum (HP:0000015)1.26127997
146Atrophy/Degeneration involving motor neurons (HP:0007373)1.26092588
147Abnormality of molar (HP:0011077)1.26000283
148Abnormality of molar morphology (HP:0011070)1.26000283
149Bell-shaped thorax (HP:0001591)1.25178157
150Long toe (HP:0010511)1.24763166
151Overriding aorta (HP:0002623)1.24708419
152Increased nuchal translucency (HP:0010880)1.23516062
153Abnormality of the dental pulp (HP:0006479)1.22027982
154Aplasia/Hypoplasia of the tongue (HP:0010295)1.21282455
155* Postaxial hand polydactyly (HP:0001162)1.20808178
156Impaired vibratory sensation (HP:0002495)1.20342568
157Acanthocytosis (HP:0001927)1.20010802
158Dyschromatopsia (HP:0007641)1.19968723

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.95419748
2PDK37.95419748
3TESK14.80722825
4PDK24.78920680
5PRKD33.87236248
6ICK3.85844280
7EPHA23.58982464
8NEK22.79036505
9SMG12.42493607
10PTK2B2.37270130
11PNCK2.26062295
12CDC71.86867401
13NTRK11.84086289
14SIK11.83197525
15EEF2K1.81723912
16WNK41.76355078
17STK391.61838745
18EPHA41.51850377
19EPHB21.50405278
20CDK121.48219043
21PDGFRA1.47154613
22MARK11.45679757
23EPHB11.37714157
24PASK1.36132843
25EPHA31.34056399
26LATS11.29667787
27MAP4K11.29060766
28DYRK1B1.27867503
29STK381.26663832
30WEE11.26638863
31FGFR41.24027375
32RPS6KA21.23963177
33LMTK21.21684523
34DDR21.19338639
35MAP3K71.12253781
36MST1R1.11604095
37FGFR21.10826478
38ATR1.08656480
39LATS21.08600868
40BCR1.07835323
41MAP3K101.05659395
42CCNB11.03534598
43TRIB31.03205626
44CAMK1G1.02192999
45DYRK31.00682294
46MET0.98986258
47TYRO30.98056393
48NME10.97691759
49WNK10.96461868
50NEK60.95721506
51STK30.95067745
52PDK10.91839024
53ERBB20.90383445
54RET0.87235934
55PTK20.87221092
56PRKD20.85421723
57CHEK20.82852019
58TTK0.81757251
59TESK20.81330893
60CHEK10.80557790
61MAPK150.78311161
62MAPKAPK30.76035264
63STK100.72145158
64SGK2230.69944258
65SGK4940.69944258
66MAP3K60.68742456
67MTOR0.67502281
68CSF1R0.63979459
69RPS6KL10.63061404
70RPS6KC10.63061404
71MAP2K70.62898329
72NTRK30.61901700
73UHMK10.60979215
74ATM0.59012192
75MAP3K20.58246829
76ROCK20.53601758
77BMX0.53542746
78RIPK10.53306698
79TAOK10.52979460
80MAP2K40.52829052
81DYRK1A0.50144546
82MAPK100.49759541
83ARAF0.49054764
84PAK60.48679603
85AKT20.47129087
86CDK40.47082925
87FER0.46670470
88RPS6KA60.45851624
89BRD40.45132614
90ROCK10.42098319
91TTN0.40859118
92CDK50.40512917
93PLK10.40490788
94KSR20.38593336
95DYRK20.37612093
96SGK30.37469656
97PKN20.37364210
98CAMK2G0.37058639
99CDK11A0.36532709
100PRKAA10.35989806
101RPS6KB20.35975191
102GRK60.35578357
103CDK150.35158492
104SRC0.34902473
105HIPK20.34859619
106PAK20.34300048
107MAP2K20.32602705
108BRSK10.32148676
109PAK10.31923372
110CDK180.31337756
111MAPK90.30326071
112MINK10.30162265
113CDK60.29529096
114SIK20.28388164
115CDK20.27806425
116PAK40.27042235
117CDK90.26155858
118PIM10.25715328
119PTK60.25083342
120IRAK10.24956854
121CAMKK10.24954102
122PDPK10.24255532
123RPS6KB10.23874319
124BTK0.23599891
125ZAP700.23310397
126STK40.23255556
127MARK30.22578721
128CAMK1D0.22174864
129CSNK1D0.20545142
130CDK10.20316142
131TYK20.20151551
132CDK70.20115843
133PRKDC0.19945280
134NTRK20.19877547
135SYK0.19858195
136AURKB0.19225143
137BUB10.18634137
138PLK40.18237909
139MARK20.17939864
140BRSK20.17378330
141LRRK20.16097702
142RPS6KA10.14453829
143MAP3K80.14413672
144ERN10.13266776
145GSK3B0.12641966
146SCYL20.11814467
147STK110.11619567
148PRKCQ0.10413493
149MAPK80.09778168
150EGFR0.08156235
151PDGFRB0.07331006
152CLK10.05680943
153MAPK10.05581549
154PRKCB0.04662804
155RPS6KA30.04157301
156JAK10.03910858
157MAPK140.03873594
158AURKA0.03657173
159CSNK2A20.03140770
160MAP3K40.02550082
161MELK0.02020659
162CDC42BPA0.01608997

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.89023224
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.39393746
3Pyruvate metabolism_Homo sapiens_hsa006203.31057294
4Dorso-ventral axis formation_Homo sapiens_hsa043202.90404986
5Fanconi anemia pathway_Homo sapiens_hsa034602.86426531
6Fatty acid biosynthesis_Homo sapiens_hsa000612.70082751
7Notch signaling pathway_Homo sapiens_hsa043302.63916793
8Glucagon signaling pathway_Homo sapiens_hsa049222.60142876
9Selenocompound metabolism_Homo sapiens_hsa004502.52562559
10Phenylalanine metabolism_Homo sapiens_hsa003602.49264445
11Basal transcription factors_Homo sapiens_hsa030222.32335235
12Pentose phosphate pathway_Homo sapiens_hsa000302.29841502
13Oocyte meiosis_Homo sapiens_hsa041142.24370648
14mRNA surveillance pathway_Homo sapiens_hsa030152.17193713
15Basal cell carcinoma_Homo sapiens_hsa052172.16783035
16RNA transport_Homo sapiens_hsa030131.98593637
17Propanoate metabolism_Homo sapiens_hsa006401.95255175
18DNA replication_Homo sapiens_hsa030301.90751422
19Axon guidance_Homo sapiens_hsa043601.87927436
20Histidine metabolism_Homo sapiens_hsa003401.73086963
21Antigen processing and presentation_Homo sapiens_hsa046121.72652979
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.72391619
23Adherens junction_Homo sapiens_hsa045201.69338279
24B cell receptor signaling pathway_Homo sapiens_hsa046621.68784757
25Tight junction_Homo sapiens_hsa045301.68321208
26Tyrosine metabolism_Homo sapiens_hsa003501.67651223
27Hippo signaling pathway_Homo sapiens_hsa043901.66663929
28Systemic lupus erythematosus_Homo sapiens_hsa053221.66313775
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66050416
30ECM-receptor interaction_Homo sapiens_hsa045121.63466247
31Glycerolipid metabolism_Homo sapiens_hsa005611.62705997
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.62563363
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55350332
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.51652966
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.51627096
36Cell cycle_Homo sapiens_hsa041101.50421450
37Melanogenesis_Homo sapiens_hsa049161.44199164
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42230810
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34797590
40Endometrial cancer_Homo sapiens_hsa052131.31932516
41Choline metabolism in cancer_Homo sapiens_hsa052311.30590451
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30197860
43Linoleic acid metabolism_Homo sapiens_hsa005911.26220963
44Homologous recombination_Homo sapiens_hsa034401.19257525
45Viral carcinogenesis_Homo sapiens_hsa052031.16251202
46Mismatch repair_Homo sapiens_hsa034301.15999124
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.15357782
48beta-Alanine metabolism_Homo sapiens_hsa004101.15287664
49Base excision repair_Homo sapiens_hsa034101.14806974
50Wnt signaling pathway_Homo sapiens_hsa043101.14714372
51Renin secretion_Homo sapiens_hsa049241.13014142
52ABC transporters_Homo sapiens_hsa020101.12690907
53Glycerophospholipid metabolism_Homo sapiens_hsa005641.11196902
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07261976
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06676847
56PPAR signaling pathway_Homo sapiens_hsa033201.06225211
57Amphetamine addiction_Homo sapiens_hsa050311.05564448
58Focal adhesion_Homo sapiens_hsa045101.04788753
59Steroid biosynthesis_Homo sapiens_hsa001001.03989926
60ErbB signaling pathway_Homo sapiens_hsa040121.03625843
61Gap junction_Homo sapiens_hsa045401.03112029
62Chemical carcinogenesis_Homo sapiens_hsa052041.02115431
63Dilated cardiomyopathy_Homo sapiens_hsa054141.01768873
64Alcoholism_Homo sapiens_hsa050341.00605186
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.99205104
66Carbon metabolism_Homo sapiens_hsa012000.95933172
67Cocaine addiction_Homo sapiens_hsa050300.95089024
68Fructose and mannose metabolism_Homo sapiens_hsa000510.93016926
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92896948
70Spliceosome_Homo sapiens_hsa030400.92670818
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92383408
72Colorectal cancer_Homo sapiens_hsa052100.87291061
73AMPK signaling pathway_Homo sapiens_hsa041520.87221725
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.86258669
75Estrogen signaling pathway_Homo sapiens_hsa049150.85217042
76VEGF signaling pathway_Homo sapiens_hsa043700.84431422
77Proteoglycans in cancer_Homo sapiens_hsa052050.84268850
78Purine metabolism_Homo sapiens_hsa002300.83234351
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.82928690
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82636289
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.80236048
82Biosynthesis of amino acids_Homo sapiens_hsa012300.79486174
83N-Glycan biosynthesis_Homo sapiens_hsa005100.79485049
84RNA degradation_Homo sapiens_hsa030180.77560505
85Thyroid cancer_Homo sapiens_hsa052160.76542635
86Non-homologous end-joining_Homo sapiens_hsa034500.76495172
87Long-term potentiation_Homo sapiens_hsa047200.76107164
88MicroRNAs in cancer_Homo sapiens_hsa052060.75964646
89HTLV-I infection_Homo sapiens_hsa051660.75462778
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75438748
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.75384891
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75105546
93Prostate cancer_Homo sapiens_hsa052150.74449125
94Nicotine addiction_Homo sapiens_hsa050330.74419425
95Nucleotide excision repair_Homo sapiens_hsa034200.72675844
96Glutamatergic synapse_Homo sapiens_hsa047240.72192275
97Sphingolipid metabolism_Homo sapiens_hsa006000.72091636
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71270037
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.71135941
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70948419
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70102790
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70096171
103Rap1 signaling pathway_Homo sapiens_hsa040150.70019976
104Glutathione metabolism_Homo sapiens_hsa004800.69362714
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68567014
106Glioma_Homo sapiens_hsa052140.68362902
107Amoebiasis_Homo sapiens_hsa051460.67757099
108Bladder cancer_Homo sapiens_hsa052190.67687732
109Protein digestion and absorption_Homo sapiens_hsa049740.67302824
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66969110
111Epstein-Barr virus infection_Homo sapiens_hsa051690.65525585
112Pathways in cancer_Homo sapiens_hsa052000.65442261
113Endocytosis_Homo sapiens_hsa041440.63557441
114Taste transduction_Homo sapiens_hsa047420.63538387
115GnRH signaling pathway_Homo sapiens_hsa049120.63333943
116cAMP signaling pathway_Homo sapiens_hsa040240.62924044
117Salivary secretion_Homo sapiens_hsa049700.62135830
118Huntingtons disease_Homo sapiens_hsa050160.62049477
119T cell receptor signaling pathway_Homo sapiens_hsa046600.61894500
120Synaptic vesicle cycle_Homo sapiens_hsa047210.60943286
121Gastric acid secretion_Homo sapiens_hsa049710.60866871
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60605343
123Prion diseases_Homo sapiens_hsa050200.60129962
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59861390
125Herpes simplex infection_Homo sapiens_hsa051680.59630979
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58375353
127Lysine degradation_Homo sapiens_hsa003100.58341594
128Fat digestion and absorption_Homo sapiens_hsa049750.57855084
129Circadian entrainment_Homo sapiens_hsa047130.57824401
130Non-small cell lung cancer_Homo sapiens_hsa052230.57691358
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57156770
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55577171
133Primary immunodeficiency_Homo sapiens_hsa053400.54781368
134Arginine and proline metabolism_Homo sapiens_hsa003300.54391697
135Fatty acid metabolism_Homo sapiens_hsa012120.54085061
136Legionellosis_Homo sapiens_hsa051340.52389230
137Cholinergic synapse_Homo sapiens_hsa047250.52270170
138Pancreatic cancer_Homo sapiens_hsa052120.50882753
139Inositol phosphate metabolism_Homo sapiens_hsa005620.50876282
140Renal cell carcinoma_Homo sapiens_hsa052110.50829152
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50295865
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49367577
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49323100
144Insulin resistance_Homo sapiens_hsa049310.48868604
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48499081
146Toxoplasmosis_Homo sapiens_hsa051450.47646958
147p53 signaling pathway_Homo sapiens_hsa041150.45257956
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44478318
149Influenza A_Homo sapiens_hsa051640.44279987
150Hedgehog signaling pathway_Homo sapiens_hsa043400.42759625
151mTOR signaling pathway_Homo sapiens_hsa041500.42482957
152Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42088427
153Measles_Homo sapiens_hsa051620.42025857
154Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41465452
155Fatty acid degradation_Homo sapiens_hsa000710.38787131
156Type II diabetes mellitus_Homo sapiens_hsa049300.38087609
157Small cell lung cancer_Homo sapiens_hsa052220.37573022
158Pyrimidine metabolism_Homo sapiens_hsa002400.37429533
159Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33204488
160Olfactory transduction_Homo sapiens_hsa047400.32869186
161Osteoclast differentiation_Homo sapiens_hsa043800.32413467
162Insulin signaling pathway_Homo sapiens_hsa049100.30524749
163Ether lipid metabolism_Homo sapiens_hsa005650.30027598
164Thyroid hormone synthesis_Homo sapiens_hsa049180.28546207
165Calcium signaling pathway_Homo sapiens_hsa040200.28444185
166Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26789029
167Chronic myeloid leukemia_Homo sapiens_hsa052200.26404386

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