IFT172

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the intraflagellar transport subcomplex IFT-B. Subcomplexes IFT-A and IFT-B are necessary for ciliary assembly and maintenance. Mutations in this gene have been associated with skeletal ciliopathies, with or without polydactyly, such as such short-rib thoracic dysplasias 1, 9 or 10. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.08890037
2sperm motility (GO:0030317)7.68090947
3fusion of sperm to egg plasma membrane (GO:0007342)7.41344882
4axonemal dynein complex assembly (GO:0070286)6.74762036
5acrosome reaction (GO:0007340)6.56311437
6epithelial cilium movement (GO:0003351)6.49012224
7acrosome assembly (GO:0001675)6.18166219
8plasma membrane fusion (GO:0045026)6.08168940
9cilium movement (GO:0003341)6.00945253
10piRNA metabolic process (GO:0034587)5.98572909
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.95689619
12sperm-egg recognition (GO:0035036)5.83030067
13multicellular organism reproduction (GO:0032504)5.67452173
14motile cilium assembly (GO:0044458)5.54487375
15male meiosis (GO:0007140)5.51434796
16microtubule bundle formation (GO:0001578)5.50749802
17synaptonemal complex organization (GO:0070193)5.48700666
18spermatid development (GO:0007286)5.45770893
19binding of sperm to zona pellucida (GO:0007339)5.28974952
20* cilium organization (GO:0044782)5.28545533
21cell-cell recognition (GO:0009988)5.24192989
22regulation of cilium movement (GO:0003352)5.20480213
23synaptonemal complex assembly (GO:0007130)5.19705156
24cell wall macromolecule metabolic process (GO:0044036)5.18843634
25cell wall macromolecule catabolic process (GO:0016998)5.18843634
26* cilium assembly (GO:0042384)5.16719749
27vitamin transmembrane transport (GO:0035461)5.04421398
28negative regulation of inclusion body assembly (GO:0090084)4.92357278
29reproduction (GO:0000003)4.82645852
30* left/right axis specification (GO:0070986)4.62283991
31primary alcohol catabolic process (GO:0034310)4.36036093
32sperm capacitation (GO:0048240)4.28336860
33lung epithelium development (GO:0060428)4.24909159
34one-carbon compound transport (GO:0019755)4.23908541
35ventricular system development (GO:0021591)4.22765443
36* cellular component assembly involved in morphogenesis (GO:0010927)4.22525103
37centriole assembly (GO:0098534)4.18934264
38left/right pattern formation (GO:0060972)4.17689553
39calcium ion-dependent exocytosis (GO:0017156)4.04716808
40single fertilization (GO:0007338)3.99306428
41ethanol metabolic process (GO:0006067)3.92767864
42cilium morphogenesis (GO:0060271)3.91934634
43diterpenoid biosynthetic process (GO:0016102)3.85019054
44fertilization (GO:0009566)3.71111764
45microtubule polymerization or depolymerization (GO:0031109)3.67549856
46regulation of inclusion body assembly (GO:0090083)3.67086718
47establishment of apical/basal cell polarity (GO:0035089)3.62572913
48negative regulation of organelle assembly (GO:1902116)3.61682477
49* cell projection assembly (GO:0030031)3.55838274
50glomerular epithelial cell development (GO:0072310)3.54820500
51DNA methylation involved in gamete generation (GO:0043046)3.54516025
52spermatogenesis (GO:0007283)3.52981513
53male gamete generation (GO:0048232)3.51106464
54microtubule depolymerization (GO:0007019)3.50845330
55regulation of microtubule-based movement (GO:0060632)3.47059738
56protein localization to cilium (GO:0061512)3.45448320
57microtubule severing (GO:0051013)3.44568680
58lateral ventricle development (GO:0021670)3.44462235
59establishment of monopolar cell polarity (GO:0061162)3.38654633
60establishment or maintenance of monopolar cell polarity (GO:0061339)3.38654633
61male meiosis I (GO:0007141)3.36061095
62membrane depolarization during action potential (GO:0086010)3.34752173
63cellular process involved in reproduction in multicellular organism (GO:0022412)3.24199728
64organic cation transport (GO:0015695)3.21678658
65germ cell development (GO:0007281)3.20048117
66gamete generation (GO:0007276)3.19914452
67negative regulation of T cell differentiation in thymus (GO:0033085)3.15252104
68cell recognition (GO:0008037)3.13535718
69ethanol oxidation (GO:0006069)3.13299988
70seminiferous tubule development (GO:0072520)3.11779326
71establishment of protein localization to Golgi (GO:0072600)3.09156993
72carnitine transmembrane transport (GO:1902603)3.08713379
73establishment of tissue polarity (GO:0007164)3.04715956
74establishment of planar polarity (GO:0001736)3.04715956
75positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.04488308
76regulation of interleukin-5 production (GO:0032674)3.04276342
77protein targeting to Golgi (GO:0000042)3.03361073
78centriole replication (GO:0007099)3.03144346
79carnitine transport (GO:0015879)3.02622297
80amino-acid betaine transport (GO:0015838)3.02622297
81regulation of short-term neuronal synaptic plasticity (GO:0048172)2.98392193
82nonmotile primary cilium assembly (GO:0035058)2.97799797
83locomotory exploration behavior (GO:0035641)2.96232600
84chromosome organization involved in meiosis (GO:0070192)2.94192829
85microtubule-based movement (GO:0007018)2.92241368
86lactate metabolic process (GO:0006089)2.88023679
87genitalia morphogenesis (GO:0035112)2.86248399
88synaptic vesicle maturation (GO:0016188)2.83562443
89retrograde transport, vesicle recycling within Golgi (GO:0000301)2.83103136
90terpenoid biosynthetic process (GO:0016114)2.83072655
91response to xenobiotic stimulus (GO:0009410)2.81140181
92cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.76218308
93retinoic acid metabolic process (GO:0042573)2.75978594
94axoneme assembly (GO:0035082)2.75820889
95negative regulation of B cell mediated immunity (GO:0002713)2.74477404
96negative regulation of immunoglobulin mediated immune response (GO:0002890)2.74477404
97regulation of interleukin-13 production (GO:0032656)2.73589086
98determination of left/right symmetry (GO:0007368)2.72399172
99negative regulation of humoral immune response (GO:0002921)2.69962271
100meiotic nuclear division (GO:0007126)2.69414521
101glycolytic process (GO:0006096)2.67711934
102* smoothened signaling pathway (GO:0007224)2.65693229
103determination of bilateral symmetry (GO:0009855)2.65654915
104activation of protein kinase A activity (GO:0034199)2.64924309
105synaptic vesicle docking involved in exocytosis (GO:0016081)2.62496913
106* microtubule-based process (GO:0007017)2.62071682
107phosphatidylethanolamine biosynthetic process (GO:0006646)2.60396812
108retinal rod cell development (GO:0046548)2.60109111
109CDP-diacylglycerol biosynthetic process (GO:0016024)2.58840764
110specification of symmetry (GO:0009799)2.58551354
111negative regulation of potassium ion transmembrane transport (GO:1901380)2.58254915
112regulation of cilium assembly (GO:1902017)2.57214829
113multicellular organismal reproductive process (GO:0048609)2.57048197
114protein polyglutamylation (GO:0018095)2.56952847
115carnitine metabolic process (GO:0009437)2.56570160
116sodium ion export (GO:0071436)2.56404376
117intraciliary transport (GO:0042073)2.56023502
118pyrimidine-containing compound transmembrane transport (GO:0072531)2.55990371
119cell communication by electrical coupling (GO:0010644)2.53532949
120calcium ion import (GO:0070509)2.52850240
121camera-type eye morphogenesis (GO:0048593)2.52454872
122negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.51983969
123lateral sprouting from an epithelium (GO:0060601)2.51746602
124* cytoplasmic microtubule organization (GO:0031122)2.50030617
125macroautophagy (GO:0016236)2.49140052
126layer formation in cerebral cortex (GO:0021819)2.48201840
127plasma membrane repair (GO:0001778)2.47329649
128membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.46653381
129regulation of protein polyubiquitination (GO:1902914)2.46387807
130photoreceptor cell maintenance (GO:0045494)2.45446154
131* organelle assembly (GO:0070925)2.45225530
132cellular potassium ion homeostasis (GO:0030007)2.44306381
133meiosis I (GO:0007127)2.43392499
134nucleoside diphosphate phosphorylation (GO:0006165)2.40019811
135establishment of nucleus localization (GO:0040023)2.39695719
136phosphatidylethanolamine metabolic process (GO:0046337)2.39569829
137sodium ion homeostasis (GO:0055078)2.37147167
138regulation of microtubule depolymerization (GO:0031114)2.35412944
139positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.34775589
140* regulation of smoothened signaling pathway (GO:0008589)2.33347139
141regulation of protein kinase A signaling (GO:0010738)2.31217966
142cAMP biosynthetic process (GO:0006171)2.30931924
143regulation of ARF protein signal transduction (GO:0032012)2.30613062
144cytoskeletal anchoring at plasma membrane (GO:0007016)2.30484952
145vocalization behavior (GO:0071625)2.29554288
146* positive regulation of smoothened signaling pathway (GO:0045880)2.29459067
147CDP-diacylglycerol metabolic process (GO:0046341)2.29453125
148peptidyl-lysine dimethylation (GO:0018027)2.29345536
149apical protein localization (GO:0045176)2.28455837
150vesicle transport along microtubule (GO:0047496)2.28100200
151gene silencing by RNA (GO:0031047)2.27393480
152neuronal ion channel clustering (GO:0045161)2.26533614
153glutamate secretion (GO:0014047)2.26123272
154cornea development in camera-type eye (GO:0061303)2.24548795
155neurotransmitter catabolic process (GO:0042135)2.24146770
156embryonic body morphogenesis (GO:0010172)2.23794135
157tolerance induction (GO:0002507)2.22489741
158carnitine shuttle (GO:0006853)2.22267792
159cell communication involved in cardiac conduction (GO:0086065)2.21982859
160phosphatidylcholine biosynthetic process (GO:0006656)2.21780317
161monoubiquitinated protein deubiquitination (GO:0035520)2.21454201
162exogenous drug catabolic process (GO:0042738)2.21102063
163axon ensheathment in central nervous system (GO:0032291)2.20799440
164central nervous system myelination (GO:0022010)2.20799440
165embryonic camera-type eye development (GO:0031076)2.18737338
166regulation of germinal center formation (GO:0002634)2.18490498
167cerebellar Purkinje cell differentiation (GO:0021702)2.17928918
168rRNA catabolic process (GO:0016075)2.15356111
169retina layer formation (GO:0010842)2.15103584
170excretion (GO:0007588)2.14506375
171brain morphogenesis (GO:0048854)2.14313045
172regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.12334233
173aldehyde catabolic process (GO:0046185)2.08108504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.61911201
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.85823093
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.83605815
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45914087
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41890612
6DROSHA_22980978_ChIP-Seq_HELA_Human2.28852398
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.27209348
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.26165437
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.17292524
10REST_21632747_ChIP-Seq_MESCs_Mouse1.94240589
11ZNF274_21170338_ChIP-Seq_K562_Hela1.87693112
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84903585
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70108033
14AR_21572438_ChIP-Seq_LNCaP_Human1.66788914
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65467002
16FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60391095
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60277153
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.59341153
19RARB_27405468_Chip-Seq_BRAIN_Mouse1.51216613
20GATA1_26923725_Chip-Seq_HPCs_Mouse1.47624481
21NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45854900
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45058518
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44193737
24ELK4_26923725_Chip-Seq_MESODERM_Mouse1.43776287
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41781808
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.40972271
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39778029
28MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35650084
29TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35258565
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.33819794
31GBX2_23144817_ChIP-Seq_PC3_Human1.32449639
32CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28576358
33SMAD4_21799915_ChIP-Seq_A2780_Human1.28388720
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.27913937
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27003933
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.25684606
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24549547
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23847505
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.23805434
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23444492
41TP53_16413492_ChIP-PET_HCT116_Human1.21949505
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.21566209
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21307616
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20631448
45CBP_20019798_ChIP-Seq_JUKART_Human1.17247395
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17247395
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16758422
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.16489463
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.16489463
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.16242817
51TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.15946360
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15690170
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.15543739
54TAF15_26573619_Chip-Seq_HEK293_Human1.13818603
55TCF4_23295773_ChIP-Seq_U87_Human1.12720277
56CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11563802
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.11197951
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10973914
59AHR_22903824_ChIP-Seq_MCF-7_Human1.09780600
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09762252
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09000287
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08412946
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08143639
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08143639
65TP63_22573176_ChIP-Seq_HFKS_Human1.07779954
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06079242
67PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05832561
68BCAT_22108803_ChIP-Seq_LS180_Human1.05470714
69SMAD4_21741376_ChIP-Seq_HESCs_Human1.04534016
70RUNX2_22187159_ChIP-Seq_PCA_Human1.04095185
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04088457
72TP53_18474530_ChIP-ChIP_U2OS_Human1.03787805
73* SMAD3_21741376_ChIP-Seq_ESCs_Human1.02544590
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02309124
75STAT3_23295773_ChIP-Seq_U87_Human1.01350201
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.01224266
77GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.01093747
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00664204
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00394591
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00298596
81TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00278473
82ETV1_20927104_ChIP-Seq_GIST48_Human0.99974079
83KLF4_19829295_ChIP-Seq_ESCs_Human0.99729917
84ER_23166858_ChIP-Seq_MCF-7_Human0.98780054
85SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98734205
86JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98085636
87EZH2_27304074_Chip-Seq_ESCs_Mouse0.97765082
88AR_19668381_ChIP-Seq_PC3_Human0.97486051
89RING1B_27294783_Chip-Seq_ESCs_Mouse0.97249817
90CBX2_27304074_Chip-Seq_ESCs_Mouse0.97159018
91* TBX20_22080862_ChIP-Seq_HEART_Mouse0.96309901
92* TBX20_22328084_ChIP-Seq_HEART_Mouse0.96309901
93ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95801755
94FLI1_21867929_ChIP-Seq_TH2_Mouse0.95562129
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94918617
96AR_25329375_ChIP-Seq_VCAP_Human0.94763971
97KDM2B_26808549_Chip-Seq_K562_Human0.94325734
98CTCF_27219007_Chip-Seq_Bcells_Human0.93744407
99SOX2_21211035_ChIP-Seq_LN229_Gbm0.93655552
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.93089174
101PHF8_20622853_ChIP-Seq_HELA_Human0.92246208
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92173054
103ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92172111
104JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91923144
105TP63_23658742_ChIP-Seq_EP156T_Human0.91795240
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91722465
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91244908
108CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91145359
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90957923
110KDM2B_26808549_Chip-Seq_REH_Human0.90931589
111KLF5_25053715_ChIP-Seq_YYC3_Human0.90682035
112E2F1_17053090_ChIP-ChIP_MCF-7_Human0.90401335
113FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90371396
114FUS_26573619_Chip-Seq_HEK293_Human0.90019670
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.89841504
116TBL1_22424771_ChIP-Seq_293T_Human0.89725400
117SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89580646
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89249947
119* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88778475
120TP53_23651856_ChIP-Seq_MEFs_Mouse0.88755638
121SMC4_20622854_ChIP-Seq_HELA_Human0.87908903
122SMAD3_21741376_ChIP-Seq_EPCs_Human0.87887724
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87629612
124FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87355639
125VDR_22108803_ChIP-Seq_LS180_Human0.86427723
126* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86154955
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85882881
128OCT1_27270436_Chip-Seq_PROSTATE_Human0.84104351
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83791017
130EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83281101
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82803962
132* FOXA2_19822575_ChIP-Seq_HepG2_Human0.82470753
133YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82176450
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82142967
135MYC_27129775_Chip-Seq_CORNEA_Mouse0.81889376
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81858502

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.68075568
2MP0008875_abnormal_xenobiotic_pharmacok3.82362437
3MP0003698_abnormal_male_reproductive3.43526681
4MP0004859_abnormal_synaptic_plasticity3.34132226
5MP0000566_synostosis2.87432410
6MP0008877_abnormal_DNA_methylation2.79689796
7MP0001929_abnormal_gametogenesis2.74824889
8MP0004043_abnormal_pH_regulation2.72778772
9MP0004133_heterotaxia2.59447545
10MP0002132_abnormal_respiratory_system2.55935476
11MP0005377_hearing/vestibular/ear_phenot2.53041068
12MP0003878_abnormal_ear_physiology2.53041068
13MP0005623_abnormal_meninges_morphology2.52207947
14MP0000751_myopathy2.41190991
15MP0009046_muscle_twitch2.22890395
16MP0004270_analgesia2.20386834
17MP0003646_muscle_fatigue2.19957346
18MP0000569_abnormal_digit_pigmentation2.19561085
19MP0002837_dystrophic_cardiac_calcinosis2.14315322
20MP0003635_abnormal_synaptic_transmissio2.12104472
21MP0001984_abnormal_olfaction2.11885976
22MP0002653_abnormal_ependyma_morphology2.10740211
23MP0003136_yellow_coat_color2.07405861
24MP0008789_abnormal_olfactory_epithelium1.98465052
25MP0002638_abnormal_pupillary_reflex1.94011887
26MP0000383_abnormal_hair_follicle1.89951305
27MP0004233_abnormal_muscle_weight1.89876034
28MP0005670_abnormal_white_adipose1.88541192
29MP0002161_abnormal_fertility/fecundity1.82971792
30MP0004145_abnormal_muscle_electrophysio1.81298640
31MP0002735_abnormal_chemical_nociception1.79455013
32MP0003283_abnormal_digestive_organ1.75689071
33MP0002249_abnormal_larynx_morphology1.75158849
34MP0002909_abnormal_adrenal_gland1.71047897
35MP0009780_abnormal_chondrocyte_physiolo1.68403859
36MP0005503_abnormal_tendon_morphology1.67349302
37MP0002210_abnormal_sex_determination1.67204321
38MP0004130_abnormal_muscle_cell1.66715394
39MP0002063_abnormal_learning/memory/cond1.58034357
40MP0005394_taste/olfaction_phenotype1.56756683
41MP0005499_abnormal_olfactory_system1.56756683
42MP0004036_abnormal_muscle_relaxation1.55389682
43MP0004858_abnormal_nervous_system1.50625464
44MP0002064_seizures1.44886263
45MP0009745_abnormal_behavioral_response1.43486082
46MP0004084_abnormal_cardiac_muscle1.43219090
47MP0001145_abnormal_male_reproductive1.39138324
48MP0003329_amyloid_beta_deposits1.37346215
49MP0001485_abnormal_pinna_reflex1.34607465
50MP0003045_fibrosis1.33395696
51MP0005423_abnormal_somatic_nervous1.25196738
52MP0002572_abnormal_emotion/affect_behav1.24647137
53MP0008961_abnormal_basal_metabolism1.23452128
54MP0002272_abnormal_nervous_system1.22070687
55MP0001440_abnormal_grooming_behavior1.21263294
56MP0002168_other_aberrant_phenotype1.20758249
57MP0000653_abnormal_sex_gland1.19653469
58MP0004215_abnormal_myocardial_fiber1.17720881
59MP0000026_abnormal_inner_ear1.17585951
60MP0010030_abnormal_orbit_morphology1.17032514
61MP0004811_abnormal_neuron_physiology1.16416716
62MP0000013_abnormal_adipose_tissue1.15295059
63MP0005083_abnormal_biliary_tract1.15044094
64MP0002234_abnormal_pharynx_morphology1.14829576
65MP0000678_abnormal_parathyroid_gland1.13995139
66MP0001968_abnormal_touch/_nociception1.13447980
67MP0001486_abnormal_startle_reflex1.13415451
68MP0001970_abnormal_pain_threshold1.12616244
69MP0010678_abnormal_skin_adnexa1.12542227
70MP0004087_abnormal_muscle_fiber1.12491574
71MP0003705_abnormal_hypodermis_morpholog1.12016331
72MP0008569_lethality_at_weaning1.10813791
73MP0005253_abnormal_eye_physiology1.10578302
74MP0000631_abnormal_neuroendocrine_gland1.09413474
75MP0002734_abnormal_mechanical_nocicepti1.08817765
76MP0001963_abnormal_hearing_physiology1.08049253
77MP0006276_abnormal_autonomic_nervous1.05552945
78MP0005248_abnormal_Harderian_gland1.05161552
79MP0003880_abnormal_central_pattern1.04417087
80MP0010234_abnormal_vibrissa_follicle1.04102243
81MP0005187_abnormal_penis_morphology1.02559771
82MP0002876_abnormal_thyroid_physiology1.01981877
83MP0003937_abnormal_limbs/digits/tail_de1.01790029
84MP0002067_abnormal_sensory_capabilities1.01057887
85MP0002269_muscular_atrophy1.00946344
86MP0004885_abnormal_endolymph0.99059487
87MP0005666_abnormal_adipose_tissue0.99058251
88MP0004019_abnormal_vitamin_homeostasis0.96902950
89MP0002277_abnormal_respiratory_mucosa0.96351207
90MP0002233_abnormal_nose_morphology0.96204806
91MP0004085_abnormal_heartbeat0.96052502
92MP0003633_abnormal_nervous_system0.95355618
93MP0001346_abnormal_lacrimal_gland0.95076089
94MP0005620_abnormal_muscle_contractility0.94059267
95MP0003787_abnormal_imprinting0.93906304
96MP0002116_abnormal_craniofacial_bone0.93545164
97MP0001765_abnormal_ion_homeostasis0.93305146
98MP0006138_congestive_heart_failure0.93151926
99MP0002822_catalepsy0.92902569
100MP0000749_muscle_degeneration0.92853699
101MP0001501_abnormal_sleep_pattern0.92378301
102MP0002108_abnormal_muscle_morphology0.91822595
103MP0002160_abnormal_reproductive_system0.91378970
104MP0005551_abnormal_eye_electrophysiolog0.90868848
105MP0000778_abnormal_nervous_system0.90714923
106* MP0003861_abnormal_nervous_system0.89687301
107MP0002184_abnormal_innervation0.87475559
108MP0000049_abnormal_middle_ear0.86913650
109MP0003942_abnormal_urinary_system0.86813633
110MP0002557_abnormal_social/conspecific_i0.86749007
111MP0005375_adipose_tissue_phenotype0.86369450
112MP0003115_abnormal_respiratory_system0.86290952
113MP0001270_distended_abdomen0.85636671
114MP0002752_abnormal_somatic_nervous0.85343379
115* MP0002882_abnormal_neuron_morphology0.83975932
116MP0002736_abnormal_nociception_after0.83957807
117MP0002282_abnormal_trachea_morphology0.83046404
118MP0005195_abnormal_posterior_eye0.82459326
119MP0000003_abnormal_adipose_tissue0.82284001
120* MP0002152_abnormal_brain_morphology0.81147669
121MP0004272_abnormal_basement_membrane0.80961975
122MP0005646_abnormal_pituitary_gland0.80219540
123MP0002106_abnormal_muscle_physiology0.77992293
124MP0005167_abnormal_blood-brain_barrier0.77431080
125MP0005330_cardiomyopathy0.76322236
126MP0003631_nervous_system_phenotype0.75670408
127MP0000747_muscle_weakness0.75445645
128MP0002733_abnormal_thermal_nociception0.75145120
129* MP0000955_abnormal_spinal_cord0.74813137
130MP0003879_abnormal_hair_cell0.74215499
131MP0000681_abnormal_thyroid_gland0.74074794
132MP0000534_abnormal_ureter_morphology0.73771461
133MP0010630_abnormal_cardiac_muscle0.72864282
134MP0002066_abnormal_motor_capabilities/c0.72845540
135MP0003656_abnormal_erythrocyte_physiolo0.72202177
136MP0000759_abnormal_skeletal_muscle0.71681505
137MP0003634_abnormal_glial_cell0.71221956
138MP0003938_abnormal_ear_development0.70909948
139MP0000427_abnormal_hair_cycle0.69049761
140MP0005369_muscle_phenotype0.68452258
141MP0005395_other_phenotype0.68185038
142MP0001299_abnormal_eye_distance/0.67950429
143MP0004924_abnormal_behavior0.67437096
144MP0005386_behavior/neurological_phenoty0.67437096
145MP0004484_altered_response_of0.67335886
146MP0003137_abnormal_impulse_conducting0.67291709
147MP0001324_abnormal_eye_pigmentation0.67278809
148MP0002229_neurodegeneration0.65552995
149MP0001502_abnormal_circadian_rhythm0.65105308

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.29903426
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.63778641
3Absent/shortened dynein arms (HP:0200106)8.63778641
4Abnormal respiratory motile cilium physiology (HP:0012261)6.75492591
5Abnormal respiratory motile cilium morphology (HP:0005938)5.95516240
6Abnormal respiratory epithelium morphology (HP:0012253)5.95516240
7Rhinitis (HP:0012384)5.67987787
8Abnormal ciliary motility (HP:0012262)5.41181302
9Chronic bronchitis (HP:0004469)5.06623337
10Infertility (HP:0000789)4.41998684
11Abnormality of the lower motor neuron (HP:0002366)4.06764583
12Pancreatic fibrosis (HP:0100732)4.04546246
13Nasal polyposis (HP:0100582)3.98338510
14Occipital encephalocele (HP:0002085)3.85536252
15True hermaphroditism (HP:0010459)3.85258636
16Abnormality of the nasal mucosa (HP:0000433)3.45957946
17Chronic sinusitis (HP:0011109)3.37266517
18Pancreatic cysts (HP:0001737)3.36452273
19Atelectasis (HP:0100750)3.07635910
20Chronic hepatic failure (HP:0100626)3.03375941
21Bronchiectasis (HP:0002110)3.00245217
22Bronchitis (HP:0012387)2.75490343
23Male infertility (HP:0003251)2.71019009
24Tubulointerstitial nephritis (HP:0001970)2.69868330
25* Nephronophthisis (HP:0000090)2.52454896
26* Postaxial foot polydactyly (HP:0001830)2.50045196
27Bundle branch block (HP:0011710)2.48707230
28Hyporeflexia of lower limbs (HP:0002600)2.46801990
29Congenital hepatic fibrosis (HP:0002612)2.45817777
30Hyperactive renin-angiotensin system (HP:0000841)2.40441015
31Medial flaring of the eyebrow (HP:0010747)2.39504904
32Exercise-induced myalgia (HP:0003738)2.39295706
33Difficulty running (HP:0009046)2.36508165
34Gait imbalance (HP:0002141)2.30152504
35Chronic otitis media (HP:0000389)2.28024731
36Focal seizures (HP:0007359)2.27168563
37Anencephaly (HP:0002323)2.19712658
38Congenital primary aphakia (HP:0007707)2.19435865
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.15710782
40Dysmetric saccades (HP:0000641)2.12917754
41Cerebral aneurysm (HP:0004944)2.10718473
42Renovascular hypertension (HP:0100817)2.10461241
43Sclerocornea (HP:0000647)2.07253475
44Postural instability (HP:0002172)2.05923168
45Heterotopia (HP:0002282)2.05876772
46Gaze-evoked nystagmus (HP:0000640)2.04615567
47Recurrent otitis media (HP:0000403)2.03811543
48Tubulointerstitial abnormality (HP:0001969)2.00719156
49* Abnormality of the renal medulla (HP:0100957)2.00014975
50Focal motor seizures (HP:0011153)1.97484898
51Amyotrophic lateral sclerosis (HP:0007354)1.96321845
52Cerebral inclusion bodies (HP:0100314)1.94820194
53Fibular hypoplasia (HP:0003038)1.94423353
54Impaired vibration sensation in the lower limbs (HP:0002166)1.93088018
55Abnormality of ocular smooth pursuit (HP:0000617)1.92791165
56Difficulty climbing stairs (HP:0003551)1.91785224
57Action tremor (HP:0002345)1.90826926
58Elfin facies (HP:0004428)1.88153209
59Hyperacusis (HP:0010780)1.87327255
60Supranuclear gaze palsy (HP:0000605)1.87019278
61Nephrogenic diabetes insipidus (HP:0009806)1.86885957
62Sudden death (HP:0001699)1.86847683
63Neurofibrillary tangles (HP:0002185)1.84971766
64Male pseudohermaphroditism (HP:0000037)1.83992335
65EMG: neuropathic changes (HP:0003445)1.80257210
66Molar tooth sign on MRI (HP:0002419)1.80038146
67Abnormality of midbrain morphology (HP:0002418)1.80038146
68Aplasia/Hypoplasia of the spleen (HP:0010451)1.76681010
69Myoglobinuria (HP:0002913)1.75393886
70Progressive cerebellar ataxia (HP:0002073)1.74997044
71Stage 5 chronic kidney disease (HP:0003774)1.74831634
72Exercise-induced muscle cramps (HP:0003710)1.74643894
73Insomnia (HP:0100785)1.74610004
74Urinary bladder sphincter dysfunction (HP:0002839)1.74239735
75* Postaxial hand polydactyly (HP:0001162)1.74174647
76Poor coordination (HP:0002370)1.72431536
77Hand muscle atrophy (HP:0009130)1.71739037
78Visual hallucinations (HP:0002367)1.71096238
79Asymmetric septal hypertrophy (HP:0001670)1.70861308
80Upper limb amyotrophy (HP:0009129)1.70261916
81Distal upper limb amyotrophy (HP:0007149)1.70261916
82Asplenia (HP:0001746)1.69851499
83Decreased circulating renin level (HP:0003351)1.68087781
84Tubular atrophy (HP:0000092)1.66685919
85Absent frontal sinuses (HP:0002688)1.66562722
86Hemiparesis (HP:0001269)1.66336098
87Myokymia (HP:0002411)1.65924862
88Ventricular fibrillation (HP:0001663)1.65289687
89Neoplasm of the heart (HP:0100544)1.64508484
90Preaxial hand polydactyly (HP:0001177)1.63572520
91Hyperkalemia (HP:0002153)1.62549925
92Cholecystitis (HP:0001082)1.61647981
93Abnormal gallbladder physiology (HP:0012438)1.61647981
94Spastic tetraparesis (HP:0001285)1.60974966
95Termporal pattern (HP:0011008)1.60592061
96Insidious onset (HP:0003587)1.60592061
97Buphthalmos (HP:0000557)1.59794433
98Impaired vibratory sensation (HP:0002495)1.58495573
99Central scotoma (HP:0000603)1.58314286
100Impaired smooth pursuit (HP:0007772)1.58026078
101Gonadotropin excess (HP:0000837)1.57944211
102Abnormality of dentin (HP:0010299)1.56846728
103Genital tract atresia (HP:0001827)1.56756649
104Broad metatarsal (HP:0001783)1.56241722
105Vaginal atresia (HP:0000148)1.56130116
106Furrowed tongue (HP:0000221)1.54429511
107Renal dysplasia (HP:0000110)1.53982149
108Neuronal loss in central nervous system (HP:0002529)1.53361158
109Rapidly progressive (HP:0003678)1.53312757
110Atonic seizures (HP:0010819)1.53096301
111Lower limb muscle weakness (HP:0007340)1.52987007
112Genetic anticipation (HP:0003743)1.52317385
113Increased variability in muscle fiber diameter (HP:0003557)1.50604961
114Ankle clonus (HP:0011448)1.50520077
115Recurrent sinusitis (HP:0011108)1.50271746
116Renal salt wasting (HP:0000127)1.49785197
117Truncal obesity (HP:0001956)1.49759078
118Global brain atrophy (HP:0002283)1.49281058
119Hyperaldosteronism (HP:0000859)1.49167381
120Abnormality of chloride homeostasis (HP:0011422)1.48318239
121Urinary urgency (HP:0000012)1.47649822
122Polydipsia (HP:0001959)1.47026173
123Abnormal drinking behavior (HP:0030082)1.47026173
124Pachygyria (HP:0001302)1.46437944
125Dysdiadochokinesis (HP:0002075)1.45984674
126Abnormality of saccadic eye movements (HP:0000570)1.45933853
127Cystic liver disease (HP:0006706)1.45596878
128Decreased central vision (HP:0007663)1.44018027
129Tubulointerstitial fibrosis (HP:0005576)1.43068232
130Decreased motor nerve conduction velocity (HP:0003431)1.42199573
131Abnormality of the dental root (HP:0006486)1.41075018
132Taurodontia (HP:0000679)1.41075018
133Abnormality of permanent molar morphology (HP:0011071)1.41075018
134Microglossia (HP:0000171)1.40936108
135Subcapsular cataract (HP:0000523)1.40426152
136Retinal dysplasia (HP:0007973)1.39183838
137Short femoral neck (HP:0100864)1.39039820
138Upper motor neuron abnormality (HP:0002127)1.38974698
139Depression (HP:0000716)1.38939762
140Absent speech (HP:0001344)1.38786166
141Short nail (HP:0001799)1.38451552
142Abnormality of the renal cortex (HP:0011035)1.36954637
143* Oculomotor apraxia (HP:0000657)1.35156087
144Abnormal rod and cone electroretinograms (HP:0008323)1.34872030
145Obstructive sleep apnea (HP:0002870)1.32148264
146Abnormality of molar (HP:0011077)1.31037063
147Abnormality of molar morphology (HP:0011070)1.31037063
148Broad distal phalanx of finger (HP:0009836)1.30840233
149Abnormality of renin-angiotensin system (HP:0000847)1.29703463
150Abnormality of the dental pulp (HP:0006479)1.28662031
151Polycystic kidney dysplasia (HP:0000113)1.28543398
152* Short thorax (HP:0010306)1.28426033
153Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.28367326
154Recurrent bronchitis (HP:0002837)1.27821497
155* Nephropathy (HP:0000112)1.25874589
156Intellectual disability, moderate (HP:0002342)1.25300106
157Bony spicule pigmentary retinopathy (HP:0007737)1.24415936
158Median cleft lip (HP:0000161)1.22554168
159Highly arched eyebrow (HP:0002553)1.22238828
160Prominent nasal bridge (HP:0000426)1.21206083
161Abnormality of the middle phalanges of the toes (HP:0010183)1.19589320
162Hyperventilation (HP:0002883)1.18891323
163Aplasia/Hypoplasia of the lens (HP:0008063)1.18829347
164* Bell-shaped thorax (HP:0001591)1.17653889
165Abnormality of macular pigmentation (HP:0008002)1.17432841
166Narrow forehead (HP:0000341)1.16175407
167Multicystic kidney dysplasia (HP:0000003)1.16098282
168Cone-rod dystrophy (HP:0000548)1.14900387
169Fetal akinesia sequence (HP:0001989)1.14232348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.11715049
2PDK46.11715049
3PRKD34.29513257
4PDK23.69612720
5ICK3.30907714
6PNCK2.45407338
7TESK12.40736937
8EPHA22.35854073
9PTK2B2.26100696
10STK381.99839105
11FRK1.97674018
12CASK1.94560727
13CAMK1G1.93941808
14NTRK31.81570588
15LMTK21.80223927
16WNK41.69776744
17TRIB31.62833270
18MST41.59130784
19EPHA41.52557690
20MAP3K91.49893160
21MAP3K41.48005266
22MAPKAPK31.46771002
23STK391.46707694
24RIPK11.44720663
25NME11.37475833
26DAPK21.36571502
27TYRO31.35924926
28WNK11.35583432
29BCR1.25044193
30PHKG21.22150371
31PHKG11.22150371
32CAMKK11.21273398
33PAK61.17238587
34PINK11.16625350
35ERBB21.16010597
36NTRK21.10846668
37NEK61.09745839
38TTN1.05619308
39EEF2K1.01765538
40PDK11.01076973
41TLK10.98798517
42NTRK10.98225055
43CAMK1D0.95524276
44PLK40.95047877
45INSRR0.94150992
46SIK20.91264478
47MINK10.90354898
48STK38L0.89267715
49KSR20.86138383
50PDGFRA0.85598058
51MET0.85063370
52MAP2K40.84686516
53MAPK150.84443755
54TTK0.84029836
55PKN20.83491989
56CDK190.83040559
57SIK10.79657659
58MARK10.78784504
59MAP2K20.76385422
60EPHA30.73059775
61PDPK10.72770576
62NEK20.72395643
63CDC42BPA0.71182658
64OXSR10.70859704
65MTOR0.69913727
66MAP3K70.68683595
67PRKAA20.68304129
68PAK30.66140932
69MAP3K20.65970222
70MARK20.65795247
71DYRK1B0.64639274
72UHMK10.64482828
73ACVR1B0.64212710
74STK110.63629980
75DYRK1A0.63290963
76MST1R0.61542158
77DMPK0.61376524
78PRKCH0.60679205
79CDK50.60030771
80RET0.59219371
81SGK30.57911632
82MAP3K60.57702544
83PTK60.57224714
84TRPM70.55798573
85CDK120.55628809
86SCYL20.55614577
87STK240.55475985
88FGFR20.53966223
89PRKCG0.53424783
90PRKAA10.52700721
91GRK10.52170829
92RIPK40.51920390
93MAP4K20.50729962
94PRKCE0.49469466
95BMPR1B0.48787644
96TIE10.47924790
97PDGFRB0.46881602
98FER0.46803848
99RPS6KA60.46139647
100LATS20.45937405
101BRD40.44819967
102STK30.43709448
103CAMK10.43526383
104CDK30.43437936
105PRKACA0.43080749
106ERBB30.42746494
107LATS10.41915327
108PLK20.41813400
109PTK20.41398114
110CAMK2G0.40962317
111PAK20.40815405
112DDR20.40175172
113CAMKK20.39802049
114PRKDC0.39480481
115AKT30.37756535
116OBSCN0.36868545
117MAP3K100.35300978
118MAPK100.34661566
119RPS6KA30.34315751
120PRKCZ0.33975767
121SGK2230.33307013
122SGK4940.33307013
123RPS6KA20.33272683
124SGK20.32509196
125ROCK10.30196685
126MAP3K130.30024196
127SGK10.29561632
128MAP2K70.28797648
129CAMK2A0.28650611
130PRKD10.27854209
131CAMK40.27724320
132MAP3K10.26364264
133MAPK80.26354713
134TAOK10.24967402
135MAPK130.24846953
136GSK3B0.21580441
137SRC0.21180423
138PRKACB0.21023514
139PRKACG0.20143309

Predicted pathways (KEGG)

RankGene SetZ-score
1Histidine metabolism_Homo sapiens_hsa003403.21165485
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.04553614
3Phenylalanine metabolism_Homo sapiens_hsa003602.87282845
4Chemical carcinogenesis_Homo sapiens_hsa052042.64044763
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.57509966
6beta-Alanine metabolism_Homo sapiens_hsa004102.22528368
7Tyrosine metabolism_Homo sapiens_hsa003502.21120784
8Olfactory transduction_Homo sapiens_hsa047402.16719328
9Dorso-ventral axis formation_Homo sapiens_hsa043202.12226087
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.01163321
11Fatty acid biosynthesis_Homo sapiens_hsa000611.93110781
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.91286394
13Synaptic vesicle cycle_Homo sapiens_hsa047211.90878528
14Glucagon signaling pathway_Homo sapiens_hsa049221.89965670
15Circadian entrainment_Homo sapiens_hsa047131.81755751
16Amphetamine addiction_Homo sapiens_hsa050311.80743981
17Linoleic acid metabolism_Homo sapiens_hsa005911.79550616
18Renin secretion_Homo sapiens_hsa049241.79539266
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78276486
20Long-term potentiation_Homo sapiens_hsa047201.76899646
21Propanoate metabolism_Homo sapiens_hsa006401.71119244
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.70542621
23Insulin secretion_Homo sapiens_hsa049111.70078301
24Salivary secretion_Homo sapiens_hsa049701.64872217
25Pyruvate metabolism_Homo sapiens_hsa006201.60770858
26Gastric acid secretion_Homo sapiens_hsa049711.58940383
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58428365
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56265630
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54916439
30Caffeine metabolism_Homo sapiens_hsa002321.53514798
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47141785
32Type II diabetes mellitus_Homo sapiens_hsa049301.46267357
33Glutamatergic synapse_Homo sapiens_hsa047241.45924175
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.44944660
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43569699
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41628823
37Nicotine addiction_Homo sapiens_hsa050331.40925752
38Retinol metabolism_Homo sapiens_hsa008301.40468359
39Huntingtons disease_Homo sapiens_hsa050161.37076958
40Morphine addiction_Homo sapiens_hsa050321.35536426
41Estrogen signaling pathway_Homo sapiens_hsa049151.34795054
42Taste transduction_Homo sapiens_hsa047421.34149513
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.34128831
44Nitrogen metabolism_Homo sapiens_hsa009101.33164973
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.32673986
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32354354
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31907231
48Calcium signaling pathway_Homo sapiens_hsa040201.28416870
49Circadian rhythm_Homo sapiens_hsa047101.26897983
50GABAergic synapse_Homo sapiens_hsa047271.24715277
51Dopaminergic synapse_Homo sapiens_hsa047281.23684758
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22781234
53Butanoate metabolism_Homo sapiens_hsa006501.21167718
54Glycerolipid metabolism_Homo sapiens_hsa005611.21075942
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19975483
56Oxytocin signaling pathway_Homo sapiens_hsa049211.18450826
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17870559
58cAMP signaling pathway_Homo sapiens_hsa040241.14346957
59PPAR signaling pathway_Homo sapiens_hsa033201.13336445
60Cardiac muscle contraction_Homo sapiens_hsa042601.12271385
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.08478561
62Dilated cardiomyopathy_Homo sapiens_hsa054141.05879637
63Fatty acid degradation_Homo sapiens_hsa000711.05015364
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04954216
65Bile secretion_Homo sapiens_hsa049761.03587188
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02442867
67Oocyte meiosis_Homo sapiens_hsa041141.01686415
68Cholinergic synapse_Homo sapiens_hsa047251.00692959
69Fatty acid metabolism_Homo sapiens_hsa012120.99957485
70Thyroid hormone synthesis_Homo sapiens_hsa049180.95029851
71Glutathione metabolism_Homo sapiens_hsa004800.93952973
72Notch signaling pathway_Homo sapiens_hsa043300.93538181
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.91909840
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.91783496
75Peroxisome_Homo sapiens_hsa041460.91279655
76Cocaine addiction_Homo sapiens_hsa050300.90523241
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88260006
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86961362
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86328829
80Pancreatic secretion_Homo sapiens_hsa049720.85481827
81AMPK signaling pathway_Homo sapiens_hsa041520.83492953
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.82824006
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.82317970
84Vitamin B6 metabolism_Homo sapiens_hsa007500.81780813
85Insulin signaling pathway_Homo sapiens_hsa049100.81567756
86Sphingolipid metabolism_Homo sapiens_hsa006000.80545149
87GnRH signaling pathway_Homo sapiens_hsa049120.80273089
88Insulin resistance_Homo sapiens_hsa049310.80045789
89Collecting duct acid secretion_Homo sapiens_hsa049660.79082496
90Gap junction_Homo sapiens_hsa045400.78549345
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77734622
92Glioma_Homo sapiens_hsa052140.75365671
93Melanogenesis_Homo sapiens_hsa049160.74097054
94mTOR signaling pathway_Homo sapiens_hsa041500.73942710
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72723450
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.72260263
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72071399
98Basal cell carcinoma_Homo sapiens_hsa052170.71592295
99ABC transporters_Homo sapiens_hsa020100.70940316
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70473925
101Ovarian steroidogenesis_Homo sapiens_hsa049130.67093022
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67003423
103Carbon metabolism_Homo sapiens_hsa012000.66155103
104Phototransduction_Homo sapiens_hsa047440.65926620
105Inositol phosphate metabolism_Homo sapiens_hsa005620.65652246
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65191991
107Arginine and proline metabolism_Homo sapiens_hsa003300.64959452
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.64616405
109Hippo signaling pathway_Homo sapiens_hsa043900.64003613
110Fructose and mannose metabolism_Homo sapiens_hsa000510.63742654
111Long-term depression_Homo sapiens_hsa047300.63284088
112Axon guidance_Homo sapiens_hsa043600.62056674
113VEGF signaling pathway_Homo sapiens_hsa043700.62002969
114Lysine degradation_Homo sapiens_hsa003100.60481806
115Tryptophan metabolism_Homo sapiens_hsa003800.59031549
116Arachidonic acid metabolism_Homo sapiens_hsa005900.57998205
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57657165
118ECM-receptor interaction_Homo sapiens_hsa045120.56561886
119Endocytosis_Homo sapiens_hsa041440.55132335
120Hedgehog signaling pathway_Homo sapiens_hsa043400.55124669
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.53714871
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53496094
123Ether lipid metabolism_Homo sapiens_hsa005650.53420156
124Adherens junction_Homo sapiens_hsa045200.50796384
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50188091
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49031486
127MAPK signaling pathway_Homo sapiens_hsa040100.47632627
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44383625
129Wnt signaling pathway_Homo sapiens_hsa043100.44325068
130Protein digestion and absorption_Homo sapiens_hsa049740.43309393
131ErbB signaling pathway_Homo sapiens_hsa040120.42666043
132Tight junction_Homo sapiens_hsa045300.42392473
133Focal adhesion_Homo sapiens_hsa045100.41751682
134Serotonergic synapse_Homo sapiens_hsa047260.38357305
135Choline metabolism in cancer_Homo sapiens_hsa052310.37412675
136Arginine biosynthesis_Homo sapiens_hsa002200.37254539
137Mineral absorption_Homo sapiens_hsa049780.37125176
138Fat digestion and absorption_Homo sapiens_hsa049750.35077128
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34422973

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