IFT20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a intraflagellar transport protein important for intracellular transport. The encoded protein forms part of a complex involved in trafficking of proteins from the Golgi body, including recycling of immune signalling components (Finetti et al., PubMed: 19855387). This gene is part of a complex set of sense-antisense loci that may be co-regulated. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.38585589
2SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.08819152
3cotranslational protein targeting to membrane (GO:0006613)5.08816300
4signal peptide processing (GO:0006465)5.03742471
5protein targeting to ER (GO:0045047)5.02705433
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.01594858
7GDP-mannose metabolic process (GO:0019673)4.94239977
8behavioral response to nicotine (GO:0035095)4.88945990
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.85841356
10ATP synthesis coupled proton transport (GO:0015986)4.85841356
11protein localization to endoplasmic reticulum (GO:0070972)4.83828346
12establishment of protein localization to endoplasmic reticulum (GO:0072599)4.79727896
13respiratory chain complex IV assembly (GO:0008535)4.71449822
14protein complex biogenesis (GO:0070271)4.65125432
15viral transcription (GO:0019083)4.57643518
16respiratory electron transport chain (GO:0022904)4.51627924
17ribosomal small subunit biogenesis (GO:0042274)4.48923333
18electron transport chain (GO:0022900)4.44253697
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.37716818
20translational termination (GO:0006415)4.37525403
21GTP biosynthetic process (GO:0006183)4.37177327
22mitochondrial respiratory chain complex I assembly (GO:0032981)4.36215024
23NADH dehydrogenase complex assembly (GO:0010257)4.36215024
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.36215024
25epithelial cilium movement (GO:0003351)4.34766991
26mannosylation (GO:0097502)4.13408409
27mitochondrial respiratory chain complex assembly (GO:0033108)4.09047395
28ribosomal small subunit assembly (GO:0000028)4.04985196
29cytochrome complex assembly (GO:0017004)4.01555617
30chaperone-mediated protein transport (GO:0072321)4.01043262
31platelet dense granule organization (GO:0060155)3.99016083
32response to pheromone (GO:0019236)3.97692341
33axoneme assembly (GO:0035082)3.90258730
34cilium movement (GO:0003341)3.90134984
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.84806235
36GPI anchor biosynthetic process (GO:0006506)3.82504803
37DNA deamination (GO:0045006)3.77849816
38proteasome assembly (GO:0043248)3.72796519
39positive regulation of cellular amine metabolic process (GO:0033240)3.68801936
40regulation of cilium movement (GO:0003352)3.68615488
41fucose catabolic process (GO:0019317)3.64934220
42L-fucose metabolic process (GO:0042354)3.64934220
43L-fucose catabolic process (GO:0042355)3.64934220
44protein neddylation (GO:0045116)3.63744911
45presynaptic membrane assembly (GO:0097105)3.61623932
46nonmotile primary cilium assembly (GO:0035058)3.61151591
47guanosine-containing compound biosynthetic process (GO:1901070)3.59042727
48protein maturation by protein folding (GO:0022417)3.56808517
49cellular ketone body metabolic process (GO:0046950)3.49382060
50axonemal dynein complex assembly (GO:0070286)3.49031603
51viral life cycle (GO:0019058)3.46174695
52protein-cofactor linkage (GO:0018065)3.46071556
53translational elongation (GO:0006414)3.45814142
54dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.45082170
55UTP biosynthetic process (GO:0006228)3.44753833
56GPI anchor metabolic process (GO:0006505)3.39849738
57cilium or flagellum-dependent cell motility (GO:0001539)3.37752023
58water-soluble vitamin biosynthetic process (GO:0042364)3.37012057
59cellular protein complex disassembly (GO:0043624)3.35494057
60ubiquinone biosynthetic process (GO:0006744)3.35067424
61termination of RNA polymerase III transcription (GO:0006386)3.33353925
62transcription elongation from RNA polymerase III promoter (GO:0006385)3.33353925
63translation (GO:0006412)3.33290039
64protein targeting to membrane (GO:0006612)3.29343198
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.26740290
66ketone body metabolic process (GO:1902224)3.17543074
67regulation of oxidative phosphorylation (GO:0002082)3.14668523
68regulation of metalloenzyme activity (GO:0048552)3.14504062
69C-terminal protein lipidation (GO:0006501)3.11048885
70presynaptic membrane organization (GO:0097090)3.10693118
71cilium morphogenesis (GO:0060271)3.08717919
72nucleoside diphosphate catabolic process (GO:0009134)3.07108048
73postsynaptic membrane organization (GO:0001941)3.06311562
74UTP metabolic process (GO:0046051)3.06260627
75ubiquinone metabolic process (GO:0006743)3.04878006
76negative regulation of telomere maintenance (GO:0032205)3.03907453
77CTP biosynthetic process (GO:0006241)3.03000074
78CTP metabolic process (GO:0046036)3.03000074
79regulation of mitochondrial translation (GO:0070129)3.02184267
80nucleoside diphosphate phosphorylation (GO:0006165)3.01281932
81indole-containing compound catabolic process (GO:0042436)3.01186499
82indolalkylamine catabolic process (GO:0046218)3.01186499
83tryptophan catabolic process (GO:0006569)3.01186499
84magnesium ion transport (GO:0015693)2.98501881
85deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.93996582
86protein polyglutamylation (GO:0018095)2.93251301
87sphingoid metabolic process (GO:0046519)2.92132803
88C-terminal protein amino acid modification (GO:0018410)2.90193304
89axon ensheathment in central nervous system (GO:0032291)2.89902441
90central nervous system myelination (GO:0022010)2.89902441
91translational initiation (GO:0006413)2.89847630
92hydrogen ion transmembrane transport (GO:1902600)2.88795862
93* cilium organization (GO:0044782)2.87618428
94ribosomal large subunit biogenesis (GO:0042273)2.85379351
95regulation of pigment cell differentiation (GO:0050932)2.85209404
96regulation of type B pancreatic cell apoptotic process (GO:2000674)2.84885126
97* protein localization to cilium (GO:0061512)2.84511139
98* intraciliary transport (GO:0042073)2.83839487
99purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.83689875
100GMP metabolic process (GO:0046037)2.83015719
101nucleotide transmembrane transport (GO:1901679)2.82507111
102negative regulation of transcription by competitive promoter binding (GO:0010944)2.81579689
103purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80976781
104indolalkylamine metabolic process (GO:0006586)2.80871700
105intracellular protein transmembrane import (GO:0044743)2.80034886
106cellular biogenic amine catabolic process (GO:0042402)2.79113195
107amine catabolic process (GO:0009310)2.79113195
108quinone biosynthetic process (GO:1901663)2.78272516
109nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.77604355
110regulation of hexokinase activity (GO:1903299)2.77564885
111regulation of glucokinase activity (GO:0033131)2.77564885
112* cilium assembly (GO:0042384)2.75813678
113nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75448219
114fatty acid elongation (GO:0030497)2.74328565
115preassembly of GPI anchor in ER membrane (GO:0016254)2.72293286
116aldehyde catabolic process (GO:0046185)2.70333285
117peptidyl-histidine modification (GO:0018202)2.70191166
118neural tube formation (GO:0001841)2.70167355
119RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69712035
120tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69712035
121proton transport (GO:0015992)2.68429073
122regulation of microtubule-based movement (GO:0060632)2.68226049
123L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.67672164
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66830792
125protein complex disassembly (GO:0043241)2.66371063
126long-chain fatty acid biosynthetic process (GO:0042759)2.65627865
127dopamine transport (GO:0015872)2.62506309
128response to redox state (GO:0051775)2.61197483
129hydrogen transport (GO:0006818)2.60536908
130ATP biosynthetic process (GO:0006754)2.59789618
131detection of light stimulus involved in sensory perception (GO:0050962)2.59249673
132detection of light stimulus involved in visual perception (GO:0050908)2.59249673
133kynurenine metabolic process (GO:0070189)2.59109636
134piRNA metabolic process (GO:0034587)2.57890604
135macromolecular complex disassembly (GO:0032984)2.57671674
136negative regulation of transcription regulatory region DNA binding (GO:2000678)2.57370607
137fucosylation (GO:0036065)2.55624129
138metallo-sulfur cluster assembly (GO:0031163)2.54208782
139iron-sulfur cluster assembly (GO:0016226)2.54208782
140sperm motility (GO:0030317)2.53676375
141regulation of cellular amino acid metabolic process (GO:0006521)2.53103351
142neuronal action potential propagation (GO:0019227)2.52364813
143protein targeting to mitochondrion (GO:0006626)2.51293752
144organelle disassembly (GO:1903008)2.48307416
145tryptophan metabolic process (GO:0006568)2.47635943
146maturation of SSU-rRNA (GO:0030490)2.47274730
147fucose metabolic process (GO:0006004)2.47071109
148multicellular organism reproduction (GO:0032504)2.47047888
149base-excision repair, AP site formation (GO:0006285)2.46341467
150glandular epithelial cell differentiation (GO:0002067)2.45310811
151negative regulation of execution phase of apoptosis (GO:1900118)2.45056013
152pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.44167995
153protein targeting (GO:0006605)2.44114838
154nucleoside diphosphate metabolic process (GO:0009132)2.43898588
155establishment of protein localization to membrane (GO:0090150)2.43002074
156gamma-aminobutyric acid transport (GO:0015812)2.42522159
157glucosamine-containing compound catabolic process (GO:1901072)2.41897708
158ribonucleoside triphosphate biosynthetic process (GO:0009201)2.41135821
159cellular response to interferon-beta (GO:0035458)2.39213299
160centriole replication (GO:0007099)2.39132436
161rRNA modification (GO:0000154)2.38897902
162kidney morphogenesis (GO:0060993)2.38245242
163regulation of neurotransmitter uptake (GO:0051580)2.37755603
164anterograde synaptic vesicle transport (GO:0048490)2.35021811
165indole-containing compound metabolic process (GO:0042430)2.34896904
166negative regulation of T cell differentiation in thymus (GO:0033085)2.34518085
167nephron tubule morphogenesis (GO:0072078)2.33645249
168nephron epithelium morphogenesis (GO:0072088)2.33645249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.56250557
2ZNF274_21170338_ChIP-Seq_K562_Hela3.86538208
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.86182362
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.58196387
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54082885
6EZH2_22144423_ChIP-Seq_EOC_Human3.25696016
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00922244
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76414008
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.70403948
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64638315
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49934030
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46213304
13* EST1_17652178_ChIP-ChIP_JURKAT_Human2.43820445
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33316298
15EWS_26573619_Chip-Seq_HEK293_Human2.15626279
16* ETS1_20019798_ChIP-Seq_JURKAT_Human2.13080042
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06145400
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03357619
19VDR_22108803_ChIP-Seq_LS180_Human1.93990987
20* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90280182
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89203806
22CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.86022426
23IRF1_19129219_ChIP-ChIP_H3396_Human1.79526206
24TAF15_26573619_Chip-Seq_HEK293_Human1.77867176
25* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77268878
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69268171
27TP53_22573176_ChIP-Seq_HFKS_Human1.67820144
28GBX2_23144817_ChIP-Seq_PC3_Human1.67133611
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.67125808
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66588050
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64011004
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62613757
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.58450480
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56633891
35MYC_18940864_ChIP-ChIP_HL60_Human1.56566834
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55922982
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.50581975
38BCAT_22108803_ChIP-Seq_LS180_Human1.50062631
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.50023231
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49514493
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.49514493
42IGF1R_20145208_ChIP-Seq_DFB_Human1.49391248
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47930392
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.46574587
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.46574083
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44016781
47CBP_20019798_ChIP-Seq_JUKART_Human1.42721696
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42721696
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.39189561
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.38731868
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38298467
52* VDR_23849224_ChIP-Seq_CD4+_Human1.35727101
53AR_25329375_ChIP-Seq_VCAP_Human1.35428430
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35325976
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.34911925
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.31888790
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.30522112
58PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.28222765
59RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25967825
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24901475
61ELK1_19687146_ChIP-ChIP_HELA_Human1.24765806
62NCOR_22424771_ChIP-Seq_293T_Human1.22560489
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21452362
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21373083
65TAL1_26923725_Chip-Seq_HPCs_Mouse1.21162268
66TCF4_22108803_ChIP-Seq_LS180_Human1.20273995
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19741832
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18630194
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18253405
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17902966
71ERG_20517297_ChIP-Seq_VCAP_Human1.17641227
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17358113
73* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16825127
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16404981
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16347820
76DCP1A_22483619_ChIP-Seq_HELA_Human1.16207534
77SMAD4_21799915_ChIP-Seq_A2780_Human1.15673569
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15450045
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14944574
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14480241
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14365827
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13920766
83EED_16625203_ChIP-ChIP_MESCs_Mouse1.13501984
84ER_23166858_ChIP-Seq_MCF-7_Human1.13480696
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13228351
86YY1_21170310_ChIP-Seq_MESCs_Mouse1.13065027
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.12605687
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12554697
89REST_21632747_ChIP-Seq_MESCs_Mouse1.12342788
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12025967
91* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10903271
92KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10687996
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09977303
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09596735
95RUNX2_22187159_ChIP-Seq_PCA_Human1.09378873
96SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08996226
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.08528451
98STAT3_23295773_ChIP-Seq_U87_Human1.08476506
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07602822
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07602822
101SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07173528
102AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06228126
103HOXB7_26014856_ChIP-Seq_BT474_Human1.06112803
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.05831573
105P53_22387025_ChIP-Seq_ESCs_Mouse1.05789086
106RNF2_27304074_Chip-Seq_NSC_Mouse1.05548668
107P300_19829295_ChIP-Seq_ESCs_Human1.05460730
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.05003269
109* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04525205
110MYC_19829295_ChIP-Seq_ESCs_Human1.04350261
111RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03843698
112* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03489699
113FOXH1_21741376_ChIP-Seq_EPCs_Human1.02905066
114TCF4_23295773_ChIP-Seq_U87_Human1.02612048
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02473791
116ERA_21632823_ChIP-Seq_H3396_Human1.02052666
117FUS_26573619_Chip-Seq_HEK293_Human1.01982447
118CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01457464
119SMAD4_21741376_ChIP-Seq_EPCs_Human1.01422557
120* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01041155
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99715457
122SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99521693
123SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99389681
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99134556
125SOX2_18555785_Chip-Seq_ESCs_Mouse0.99005220
126AR_20517297_ChIP-Seq_VCAP_Human0.98495955
127EZH2_27294783_Chip-Seq_NPCs_Mouse0.98485399
128TAF2_19829295_ChIP-Seq_ESCs_Human0.98221019
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97873230
130HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97867878
131SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97402472
132P300_18555785_Chip-Seq_ESCs_Mouse0.96746296
133NMYC_18555785_Chip-Seq_ESCs_Mouse0.96615484
134EZH2_27294783_Chip-Seq_ESCs_Mouse0.95519674
135CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95461659
136SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95375504
137SMAD1_18555785_Chip-Seq_ESCs_Mouse0.95197720
138NANOG_20526341_ChIP-Seq_ESCs_Human0.95090158
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93662014
140HTT_18923047_ChIP-ChIP_STHdh_Human0.93554492
141PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92110169
142* FOXP3_21729870_ChIP-Seq_TREG_Human0.91922392
143SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90681182
144ZFX_18555785_Chip-Seq_ESCs_Mouse0.90290790
145* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90235486
146CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90225578
147KLF4_18555785_Chip-Seq_ESCs_Mouse0.89612527
148SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89359240
149GATA3_21867929_ChIP-Seq_CD8_Mouse0.89106557
150MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87953713
151STAT1_20625510_ChIP-Seq_HELA_Human0.87368585
152SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.86059893
153NANOG_19829295_ChIP-Seq_ESCs_Human0.86012494
154SOX2_19829295_ChIP-Seq_ESCs_Human0.86012494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.40463871
2MP0003136_yellow_coat_color3.61873384
3MP0003880_abnormal_central_pattern3.47215381
4MP0001188_hyperpigmentation3.28195636
5MP0005409_darkened_coat_color2.98773668
6MP0004381_abnormal_hair_follicle2.68206587
7MP0002876_abnormal_thyroid_physiology2.65983914
8MP0001986_abnormal_taste_sensitivity2.54696818
9MP0005379_endocrine/exocrine_gland_phen2.53881983
10MP0010386_abnormal_urinary_bladder2.52632847
11MP0008875_abnormal_xenobiotic_pharmacok2.47198123
12MP0006292_abnormal_olfactory_placode2.45433274
13MP0002638_abnormal_pupillary_reflex2.11478985
14MP0008872_abnormal_physiological_respon2.02562741
15MP0002163_abnormal_gland_morphology2.01633702
16MP0005084_abnormal_gallbladder_morpholo2.01215583
17MP0006276_abnormal_autonomic_nervous1.99530447
18MP0000372_irregular_coat_pigmentation1.89592230
19MP0009046_muscle_twitch1.85499182
20MP0005220_abnormal_exocrine_pancreas1.84302320
21MP0001529_abnormal_vocalization1.84165713
22MP0000681_abnormal_thyroid_gland1.79759918
23MP0001905_abnormal_dopamine_level1.79020196
24MP0008877_abnormal_DNA_methylation1.78004516
25MP0005253_abnormal_eye_physiology1.71776687
26MP0004133_heterotaxia1.71557946
27MP0002693_abnormal_pancreas_physiology1.69791844
28MP0002653_abnormal_ependyma_morphology1.69768470
29MP0004043_abnormal_pH_regulation1.69646751
30MP0005174_abnormal_tail_pigmentation1.65384919
31MP0004885_abnormal_endolymph1.61061327
32MP0004147_increased_porphyrin_level1.60615789
33MP0003724_increased_susceptibility_to1.59924912
34MP0003868_abnormal_feces_composition1.57515323
35MP0008995_early_reproductive_senescence1.52629933
36MP0000613_abnormal_salivary_gland1.48294030
37MP0001664_abnormal_digestion1.47703954
38MP0001968_abnormal_touch/_nociception1.46420331
39MP0002837_dystrophic_cardiac_calcinosis1.46133975
40MP0001944_abnormal_pancreas_morphology1.45925266
41MP0008260_abnormal_autophagy1.43070149
42MP0002938_white_spotting1.42909047
43MP0003183_abnormal_peptide_metabolism1.42437297
44MP0004142_abnormal_muscle_tone1.40358379
45MP0005075_abnormal_melanosome_morpholog1.40185116
46MP0000015_abnormal_ear_pigmentation1.40118738
47MP0003195_calcinosis1.37526691
48MP0002736_abnormal_nociception_after1.35640128
49MP0000427_abnormal_hair_cycle1.34236877
50MP0002272_abnormal_nervous_system1.34131836
51MP0002277_abnormal_respiratory_mucosa1.33485554
52MP0001486_abnormal_startle_reflex1.32500329
53MP0003879_abnormal_hair_cell1.32293221
54MP0002735_abnormal_chemical_nociception1.31295933
55MP0000631_abnormal_neuroendocrine_gland1.29606228
56MP0005636_abnormal_mineral_homeostasis1.29220034
57MP0002132_abnormal_respiratory_system1.25907448
58MP0006072_abnormal_retinal_apoptosis1.25679320
59MP0004270_analgesia1.24671295
60MP0002572_abnormal_emotion/affect_behav1.23006616
61MP0000569_abnormal_digit_pigmentation1.21096883
62MP0005646_abnormal_pituitary_gland1.19802402
63MP0002282_abnormal_trachea_morphology1.19607465
64MP0002928_abnormal_bile_duct1.18412504
65MP0008004_abnormal_stomach_pH1.17803170
66MP0002734_abnormal_mechanical_nocicepti1.16360346
67MP0005551_abnormal_eye_electrophysiolog1.14728412
68MP0000566_synostosis1.13439899
69MP0003787_abnormal_imprinting1.13021222
70MP0005389_reproductive_system_phenotype1.11210633
71MP0001666_abnormal_nutrient_absorption1.10994227
72MP0005377_hearing/vestibular/ear_phenot1.10892121
73MP0003878_abnormal_ear_physiology1.10892121
74MP0002095_abnormal_skin_pigmentation1.10666530
75MP0005171_absent_coat_pigmentation1.10243535
76MP0000678_abnormal_parathyroid_gland1.09297293
77MP0006036_abnormal_mitochondrial_physio1.08961261
78MP0001324_abnormal_eye_pigmentation1.07808444
79MP0002751_abnormal_autonomic_nervous1.06991632
80MP0001970_abnormal_pain_threshold1.06462619
81MP0003806_abnormal_nucleotide_metabolis1.04347682
82MP0003646_muscle_fatigue1.03947191
83MP0003252_abnormal_bile_duct0.99731640
84MP0002009_preneoplasia0.99386991
85MP0003011_delayed_dark_adaptation0.98524056
86MP0004782_abnormal_surfactant_physiolog0.98277658
87MP0005451_abnormal_body_composition0.97483247
88MP0005332_abnormal_amino_acid0.95609719
89MP0002177_abnormal_outer_ear0.94527534
90MP0003186_abnormal_redox_activity0.94513463
91MP0005408_hypopigmentation0.94475699
92MP0003122_maternal_imprinting0.94273232
93MP0005085_abnormal_gallbladder_physiolo0.93438904
94MP0008058_abnormal_DNA_repair0.93333075
95MP0004924_abnormal_behavior0.93175567
96MP0005386_behavior/neurological_phenoty0.93175567
97MP0001765_abnormal_ion_homeostasis0.92989764
98MP0001542_abnormal_bone_strength0.91329312
99MP0000230_abnormal_systemic_arterial0.90824365
100MP0005423_abnormal_somatic_nervous0.90413096
101MP0008789_abnormal_olfactory_epithelium0.90235543
102MP0003283_abnormal_digestive_organ0.90215003
103MP0005195_abnormal_posterior_eye0.89345891
104MP0000516_abnormal_urinary_system0.88929555
105MP0005367_renal/urinary_system_phenotyp0.88929555
106MP0004145_abnormal_muscle_electrophysio0.88831184
107MP0000049_abnormal_middle_ear0.88806020
108MP0010329_abnormal_lipoprotein_level0.88024323
109MP0000026_abnormal_inner_ear0.87051038
110MP0008775_abnormal_heart_ventricle0.86768048
111MP0000538_abnormal_urinary_bladder0.86422284
112MP0002148_abnormal_hypersensitivity_rea0.85764908
113MP0002067_abnormal_sensory_capabilities0.85737683
114MP0003718_maternal_effect0.84301941
115MP0003959_abnormal_lean_body0.84301439
116MP0005365_abnormal_bile_salt0.83247701
117MP0003698_abnormal_male_reproductive0.83177772
118MP0001502_abnormal_circadian_rhythm0.82961961
119MP0001756_abnormal_urination0.82864799
120MP0000920_abnormal_myelination0.81920790
121MP0002229_neurodegeneration0.80979207
122MP0002160_abnormal_reproductive_system0.80255969
123MP0009745_abnormal_behavioral_response0.79286974
124MP0005083_abnormal_biliary_tract0.78558677
125MP0002102_abnormal_ear_morphology0.78493754
126MP0001963_abnormal_hearing_physiology0.76670966
127MP0001501_abnormal_sleep_pattern0.76003027
128MP0001485_abnormal_pinna_reflex0.75938019
129MP0004742_abnormal_vestibular_system0.75766564
130MP0005645_abnormal_hypothalamus_physiol0.75292577
131MP0002064_seizures0.74994940
132MP0001764_abnormal_homeostasis0.74937892
133MP0000013_abnormal_adipose_tissue0.74593107
134MP0002139_abnormal_hepatobiliary_system0.74476085
135MP0002184_abnormal_innervation0.74072778
136MP0005381_digestive/alimentary_phenotyp0.73904214
137MP0000462_abnormal_digestive_system0.73216552
138MP0005410_abnormal_fertilization0.72473244
139MP0009250_abnormal_appendicular_skeleto0.72252859
140MP0002733_abnormal_thermal_nociception0.72133984
141MP0002557_abnormal_social/conspecific_i0.72072200
142MP0001984_abnormal_olfaction0.70350118
143MP0003315_abnormal_perineum_morphology0.69478199
144MP0001663_abnormal_digestive_system0.69127862

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)5.12154268
2Acute necrotizing encephalopathy (HP:0006965)4.81549050
3Reduced antithrombin III activity (HP:0001976)4.69011792
4Mitochondrial inheritance (HP:0001427)4.67780774
5Increased hepatocellular lipid droplets (HP:0006565)4.52098023
6Hypothermia (HP:0002045)4.46238729
7Renal Fanconi syndrome (HP:0001994)4.42720303
8Hepatocellular necrosis (HP:0001404)4.34750479
9Abnormality of midbrain morphology (HP:0002418)4.28192131
10Molar tooth sign on MRI (HP:0002419)4.28192131
11Abnormal mitochondria in muscle tissue (HP:0008316)4.26888502
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.08741634
13Lipid accumulation in hepatocytes (HP:0006561)4.07168677
14Abnormal protein glycosylation (HP:0012346)4.00933176
15Abnormal glycosylation (HP:0012345)4.00933176
16Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.00933176
17Abnormal protein N-linked glycosylation (HP:0012347)4.00933176
18Progressive macrocephaly (HP:0004481)3.98887642
193-Methylglutaconic aciduria (HP:0003535)3.96723493
20Acute encephalopathy (HP:0006846)3.95313557
21Nephronophthisis (HP:0000090)3.93380362
22Hepatic necrosis (HP:0002605)3.89141692
23Increased CSF lactate (HP:0002490)3.76706121
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.74616470
25Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.60637228
26Congenital stationary night blindness (HP:0007642)3.51519492
27Abnormality of cells of the erythroid lineage (HP:0012130)3.50300772
28Abnormality of the renal medulla (HP:0100957)3.34457979
29Increased intramyocellular lipid droplets (HP:0012240)3.33780748
30Abnormal number of erythroid precursors (HP:0012131)3.28851617
31Abnormality of renal resorption (HP:0011038)3.20269214
32Exertional dyspnea (HP:0002875)3.19239207
33Abnormality of the renal cortex (HP:0011035)3.02483943
34Optic disc pallor (HP:0000543)2.96015482
35Cystic liver disease (HP:0006706)2.93056861
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.88029477
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.88029477
38Chronic hepatic failure (HP:0100626)2.83611784
39Increased muscle lipid content (HP:0009058)2.77502721
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.70344057
41Tubular atrophy (HP:0000092)2.69411786
42Congenital ichthyosiform erythroderma (HP:0007431)2.66038757
43Exercise intolerance (HP:0003546)2.62790066
44Respiratory difficulties (HP:0002880)2.61117663
45Thyroid-stimulating hormone excess (HP:0002925)2.60270255
46Cerebral edema (HP:0002181)2.58499921
47Macrocytic anemia (HP:0001972)2.56567742
48Prolonged partial thromboplastin time (HP:0003645)2.53436386
49Respiratory failure (HP:0002878)2.50314121
50Sclerocornea (HP:0000647)2.49815409
51True hermaphroditism (HP:0010459)2.48799704
52Aplasia/hypoplasia of the uterus (HP:0008684)2.47519566
53Increased serum lactate (HP:0002151)2.47073803
54Lactic acidosis (HP:0003128)2.46212065
55Hyperphosphaturia (HP:0003109)2.42191561
56Abnormal ciliary motility (HP:0012262)2.39458270
57Congenital, generalized hypertrichosis (HP:0004540)2.35966876
58Abnormal drinking behavior (HP:0030082)2.35571024
59Polydipsia (HP:0001959)2.35571024
60Abnormality of urine glucose concentration (HP:0011016)2.33206604
61Glycosuria (HP:0003076)2.33206604
62Concave nail (HP:0001598)2.32922772
63Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.32544183
64Male pseudohermaphroditism (HP:0000037)2.31417713
65Abnormality of alanine metabolism (HP:0010916)2.31037706
66Hyperalaninemia (HP:0003348)2.31037706
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31037706
68Aplasia/Hypoplasia of the tongue (HP:0010295)2.27951899
69Pancreatic cysts (HP:0001737)2.27058702
70Anencephaly (HP:0002323)2.26488830
71Abnormal respiratory motile cilium physiology (HP:0012261)2.25790275
72Medial flaring of the eyebrow (HP:0010747)2.24174409
73Methylmalonic acidemia (HP:0002912)2.22559107
74Microvesicular hepatic steatosis (HP:0001414)2.20726068
75Genital tract atresia (HP:0001827)2.20670289
76Severe visual impairment (HP:0001141)2.20641334
77Abolished electroretinogram (ERG) (HP:0000550)2.20570013
78Vaginal atresia (HP:0000148)2.19892629
79Nonprogressive disorder (HP:0003680)2.19419430
80Congenital hepatic fibrosis (HP:0002612)2.19349080
81Split foot (HP:0001839)2.16363882
82Decreased central vision (HP:0007663)2.16086216
83Parakeratosis (HP:0001036)2.16007983
84Increased corneal curvature (HP:0100692)2.15400381
85Keratoconus (HP:0000563)2.15400381
86Renal cortical cysts (HP:0000803)2.15121471
87Cortical visual impairment (HP:0100704)2.14449567
88Abnormality of secondary sexual hair (HP:0009888)2.12453861
89Abnormality of the axillary hair (HP:0100134)2.12453861
90Occipital encephalocele (HP:0002085)2.12083707
91Reticulocytopenia (HP:0001896)2.11668487
92Pancreatic fibrosis (HP:0100732)2.11629986
93Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11337464
94Abnormality of magnesium homeostasis (HP:0004921)2.10690526
95Abnormal rod and cone electroretinograms (HP:0008323)2.10121897
96Abnormal biliary tract physiology (HP:0012439)2.09538857
97Bile duct proliferation (HP:0001408)2.09538857
98Stomach cancer (HP:0012126)2.07162310
99Vacuolated lymphocytes (HP:0001922)2.04931710
100Abnormal pupillary function (HP:0007686)2.02926515
101Cerebellar dysplasia (HP:0007033)2.01999485
102Inability to walk (HP:0002540)2.01931827
103Hyperventilation (HP:0002883)2.01538980
104Pendular nystagmus (HP:0012043)2.01235820
105Abnormal urine phosphate concentration (HP:0012599)2.00568425
106Postaxial foot polydactyly (HP:0001830)2.00547340
107Methylmalonic aciduria (HP:0012120)2.00200002
108Abnormal respiratory epithelium morphology (HP:0012253)1.98529430
109Abnormal respiratory motile cilium morphology (HP:0005938)1.98529430
110Leukodystrophy (HP:0002415)1.98215769
111Aplasia/Hypoplasia of the tibia (HP:0005772)1.96207964
112Furrowed tongue (HP:0000221)1.94673643
113Pallor (HP:0000980)1.94589610
114Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93833363
115Progressive inability to walk (HP:0002505)1.93571483
116Large for gestational age (HP:0001520)1.91130603
117Retinal dysplasia (HP:0007973)1.90546337
118Polyuria (HP:0000103)1.90434065
119Conjugated hyperbilirubinemia (HP:0002908)1.89054144
120Hemiparesis (HP:0001269)1.88766074
121Patchy hypopigmentation of hair (HP:0011365)1.87985956
122Congenital sensorineural hearing impairment (HP:0008527)1.87323553
123Sensory axonal neuropathy (HP:0003390)1.87255636
124Renal tubular dysfunction (HP:0000124)1.85857072
125Poor coordination (HP:0002370)1.85233594
126Abnormality of aromatic amino acid family metabolism (HP:0004338)1.84447684
127Rhinitis (HP:0012384)1.83632080
128Flat occiput (HP:0005469)1.83499707
129Postaxial hand polydactyly (HP:0001162)1.81763288
130Attenuation of retinal blood vessels (HP:0007843)1.76576373
131Nephrogenic diabetes insipidus (HP:0009806)1.76225229
132Hypoplasia of the uterus (HP:0000013)1.75954446
133Lissencephaly (HP:0001339)1.75633267
134Congenital primary aphakia (HP:0007707)1.75253327
135Progressive cerebellar ataxia (HP:0002073)1.74832236
136Limb dystonia (HP:0002451)1.72722013
137Dynein arm defect of respiratory motile cilia (HP:0012255)1.71192154
138Absent/shortened dynein arms (HP:0200106)1.71192154
139Short tibia (HP:0005736)1.70933329
140Optic nerve hypoplasia (HP:0000609)1.70171060
141Tubulointerstitial abnormality (HP:0001969)1.70049769
142Gait imbalance (HP:0002141)1.69065923
143Hypomagnesemia (HP:0002917)1.66624676
144Aplastic anemia (HP:0001915)1.64474253
145Type II lissencephaly (HP:0007260)1.62616682
146Lethargy (HP:0001254)1.61612974
147Poor suck (HP:0002033)1.60008969
148Chronic bronchitis (HP:0004469)1.59667694
149X-linked dominant inheritance (HP:0001423)1.57820338
150Abnormality of calcium-phosphate metabolism (HP:0100530)1.56525889
151Type 2 muscle fiber atrophy (HP:0003554)1.54979827
152CNS demyelination (HP:0007305)1.54003639
153Emotional lability (HP:0000712)1.53341201
154Decreased circulating renin level (HP:0003351)1.52913099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.76120573
2CASK3.75142411
3STK163.56354602
4NME23.37472637
5MUSK3.27904930
6EIF2AK33.18613324
7MAP4K23.11636219
8TLK12.36441467
9ZAK2.33179045
10WNK32.28984815
11PINK12.05759433
12NLK2.00872835
13MAP3K121.99088160
14MST41.95790277
15NME11.92204210
16VRK21.91002154
17STK391.80172317
18MKNK21.79893699
19CDK191.77505864
20IRAK31.77084581
21MAPK151.75337995
22ACVR1B1.66240122
23PNCK1.64272523
24BMPR1B1.60586919
25VRK11.56704280
26MAP2K71.52698143
27BCKDK1.44480966
28CAMKK21.41415469
29PIM21.39419185
30SRPK11.37169974
31IRAK41.35904427
32MAP3K41.34746387
33TRIM281.33637390
34IRAK11.33614599
35INSRR1.33388369
36TAOK31.27725376
37ADRBK21.25967340
38BRSK21.24358535
39TEC1.20761356
40GRK71.20745533
41OXSR11.20469667
42PAK31.19638632
43MYLK1.17937756
44WNK41.17504002
45BMPR21.14756319
46MAPKAPK51.14548037
47PTK2B1.12982240
48IRAK21.11094520
49ARAF1.11090256
50BRAF1.07295608
51PIK3CG1.04654283
52DYRK21.03283969
53GRK51.03033517
54TIE11.02510454
55PRKCG1.01007832
56PBK0.99447988
57PLK20.96626320
58CAMK2B0.95009019
59DAPK20.91332246
60ERBB30.89956200
61MKNK10.88613042
62TGFBR10.86635178
63EIF2AK20.83204309
64FES0.81288185
65MARK10.81056233
66CAMK2D0.80969665
67CSNK1G30.80766207
68PASK0.79829775
69EPHA30.78513394
70HIPK20.76614246
71YES10.76174024
72CSNK1G10.75881096
73MAPK130.75618420
74MAP2K20.72289250
75EIF2AK10.72022029
76NEK60.71031834
77IKBKB0.70241418
78CDK30.69075589
79BUB10.67669219
80UHMK10.66174138
81CAMK10.64893254
82STK38L0.64751477
83PDK20.63979809
84PIK3CA0.63180185
85BLK0.62734107
86FRK0.60825879
87CDK80.60045676
88AKT30.59543014
89BCR0.59125305
90KIT0.59044291
91RIPK40.58914191
92MAPKAPK30.58859754
93CAMK2A0.56734706
94GRK10.55719044
95PLK40.53551130
96CAMK2G0.53514265
97DYRK1A0.52505134
98TXK0.52183449
99PLK30.52141728
100DYRK30.49019862
101PRKCE0.47422684
102PRPF4B0.47251843
103SYK0.46610645
104CSNK1G20.46216657
105PRKG20.46134759
106CLK10.45062170
107NUAK10.44389668
108WEE10.44334589
109PRKD20.44298146
110ADRBK10.44266536
111PHKG10.43475275
112PHKG20.43475275
113RPS6KA50.42879791
114FLT30.42468410
115PRKCQ0.41748493
116EPHA40.41655382
117LYN0.41285120
118PRKCI0.41267028
119MAP3K20.40882359
120CSNK1A1L0.40522273
121PRKACA0.40257882
122ABL20.38289168
123NTRK30.37600199
124DAPK30.37152749
125MAP3K30.37104950
126CSNK2A10.37067205
127PRKCA0.36936927
128LIMK10.36115926
129MAPK40.35900036
130CSNK1A10.35579866
131FER0.35543385
132MAP3K110.35118022
133BTK0.34942859
134PKN10.34797061
135CCNB10.33137440
136IKBKE0.32750679
137MAP2K60.30353211
138MINK10.29575721
139ITK0.28783068
140FGFR20.28290980

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.79675087
2Oxidative phosphorylation_Homo sapiens_hsa001904.51128568
3Ribosome_Homo sapiens_hsa030104.31383240
4Parkinsons disease_Homo sapiens_hsa050123.48647458
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.98751343
6Alzheimers disease_Homo sapiens_hsa050102.84420377
7Huntingtons disease_Homo sapiens_hsa050162.52330409
8Proteasome_Homo sapiens_hsa030502.36128887
9RNA polymerase_Homo sapiens_hsa030202.20477644
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.17924250
11Sulfur metabolism_Homo sapiens_hsa009202.12181222
12Nitrogen metabolism_Homo sapiens_hsa009101.99490250
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90404155
14Butanoate metabolism_Homo sapiens_hsa006501.82350431
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.74303963
16Fatty acid elongation_Homo sapiens_hsa000621.69672964
17Folate biosynthesis_Homo sapiens_hsa007901.68533176
18Vibrio cholerae infection_Homo sapiens_hsa051101.64993300
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64731321
20Sphingolipid metabolism_Homo sapiens_hsa006001.62376486
21Selenocompound metabolism_Homo sapiens_hsa004501.61939190
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57105161
23Collecting duct acid secretion_Homo sapiens_hsa049661.49162202
24N-Glycan biosynthesis_Homo sapiens_hsa005101.49035390
25Caffeine metabolism_Homo sapiens_hsa002321.48696603
26Arachidonic acid metabolism_Homo sapiens_hsa005901.46021387
27Other glycan degradation_Homo sapiens_hsa005111.38893641
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38286095
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37377982
30Tryptophan metabolism_Homo sapiens_hsa003801.35796828
31Pyrimidine metabolism_Homo sapiens_hsa002401.33259377
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.30906782
33Linoleic acid metabolism_Homo sapiens_hsa005911.25994244
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.25770552
35Propanoate metabolism_Homo sapiens_hsa006401.25044898
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19399983
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17867846
38Phototransduction_Homo sapiens_hsa047441.17745060
39Pancreatic secretion_Homo sapiens_hsa049721.17471548
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.12442828
41Steroid biosynthesis_Homo sapiens_hsa001001.12346680
42Regulation of autophagy_Homo sapiens_hsa041401.10806239
43Ether lipid metabolism_Homo sapiens_hsa005651.10293499
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07990301
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06936605
46Cardiac muscle contraction_Homo sapiens_hsa042601.05404739
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03622429
48Basal transcription factors_Homo sapiens_hsa030221.00887482
49Homologous recombination_Homo sapiens_hsa034400.98302347
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97687132
51Purine metabolism_Homo sapiens_hsa002300.96179650
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95638941
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94680651
54Sulfur relay system_Homo sapiens_hsa041220.93682152
55Metabolic pathways_Homo sapiens_hsa011000.93065219
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91864337
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89417576
58Histidine metabolism_Homo sapiens_hsa003400.88171170
59beta-Alanine metabolism_Homo sapiens_hsa004100.88130398
60Olfactory transduction_Homo sapiens_hsa047400.85472108
61Serotonergic synapse_Homo sapiens_hsa047260.85145904
62Glutathione metabolism_Homo sapiens_hsa004800.73419341
63Taste transduction_Homo sapiens_hsa047420.73316136
64Nicotine addiction_Homo sapiens_hsa050330.69369936
65Rheumatoid arthritis_Homo sapiens_hsa053230.69369538
66Graft-versus-host disease_Homo sapiens_hsa053320.66341632
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65914712
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64287033
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64196858
70Mineral absorption_Homo sapiens_hsa049780.64105974
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63355481
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62182344
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.60909548
74Fat digestion and absorption_Homo sapiens_hsa049750.55238618
75Nucleotide excision repair_Homo sapiens_hsa034200.54603110
76Insulin secretion_Homo sapiens_hsa049110.53863723
77Protein digestion and absorption_Homo sapiens_hsa049740.52672394
78Glycerolipid metabolism_Homo sapiens_hsa005610.49862735
79One carbon pool by folate_Homo sapiens_hsa006700.49143345
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48160199
81ABC transporters_Homo sapiens_hsa020100.47457393
82Vitamin digestion and absorption_Homo sapiens_hsa049770.47240428
83Circadian rhythm_Homo sapiens_hsa047100.46827651
84Cocaine addiction_Homo sapiens_hsa050300.46611200
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45861448
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45252467
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45165653
88Retinol metabolism_Homo sapiens_hsa008300.44308550
89Amphetamine addiction_Homo sapiens_hsa050310.44175480
90Fanconi anemia pathway_Homo sapiens_hsa034600.43822243
91Spliceosome_Homo sapiens_hsa030400.43632057
92Arginine and proline metabolism_Homo sapiens_hsa003300.43428611
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.42887372
94Peroxisome_Homo sapiens_hsa041460.42328040
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.40499907
96Ovarian steroidogenesis_Homo sapiens_hsa049130.40353109
97Salivary secretion_Homo sapiens_hsa049700.39523442
98Synaptic vesicle cycle_Homo sapiens_hsa047210.38559281
99DNA replication_Homo sapiens_hsa030300.36191336
100Chemical carcinogenesis_Homo sapiens_hsa052040.33022657
101Long-term depression_Homo sapiens_hsa047300.31675557
102Glutamatergic synapse_Homo sapiens_hsa047240.30007859
103Phagosome_Homo sapiens_hsa041450.29675472
104GABAergic synapse_Homo sapiens_hsa047270.29361681
105Renin-angiotensin system_Homo sapiens_hsa046140.29273712
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29002458
107RNA degradation_Homo sapiens_hsa030180.28309861
108Autoimmune thyroid disease_Homo sapiens_hsa053200.27918335
109Thyroid cancer_Homo sapiens_hsa052160.27722147
110Asthma_Homo sapiens_hsa053100.27171341
111Tyrosine metabolism_Homo sapiens_hsa003500.25553312
112Type I diabetes mellitus_Homo sapiens_hsa049400.25474904
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.24810339
114Alcoholism_Homo sapiens_hsa050340.24340323
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23972837
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23568372
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22304650
118Morphine addiction_Homo sapiens_hsa050320.21380267
119Thyroid hormone synthesis_Homo sapiens_hsa049180.21327682
120Calcium signaling pathway_Homo sapiens_hsa040200.19509123
121Circadian entrainment_Homo sapiens_hsa047130.18795940
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17358343
123Hematopoietic cell lineage_Homo sapiens_hsa046400.16532554
124Allograft rejection_Homo sapiens_hsa053300.16285285
125Dopaminergic synapse_Homo sapiens_hsa047280.14676538

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