IFT43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the intraflagellar transport complex A (IFT-A). IFT-A is a multiprotein complex that plays an important role in cilia assembly and maintenance by mediating retrograde ciliary transport. Mutations in this gene are a cause of cranioectodermal dysplasia-3 (CED3), also known as Sensenbrenner syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.03441662
2central nervous system myelination (GO:0022010)7.03441662
3axonemal dynein complex assembly (GO:0070286)6.24925192
4cilium movement (GO:0003341)5.84369909
5epithelial cilium movement (GO:0003351)5.27793320
6protein neddylation (GO:0045116)5.07909369
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.07203385
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.93666575
9GTP biosynthetic process (GO:0006183)4.69458781
10cilium or flagellum-dependent cell motility (GO:0001539)4.60456520
11axoneme assembly (GO:0035082)4.59948281
12mitochondrial respiratory chain complex assembly (GO:0033108)4.25910978
13protein localization to cilium (GO:0061512)4.15373989
14* intraciliary transport (GO:0042073)4.12890266
15centriole replication (GO:0007099)4.12747088
16sensory perception of smell (GO:0007608)3.95865065
17left/right pattern formation (GO:0060972)3.94316099
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.93182001
19piRNA metabolic process (GO:0034587)3.87332153
20UTP biosynthetic process (GO:0006228)3.84594783
21motile cilium assembly (GO:0044458)3.83505114
22photoreceptor cell differentiation (GO:0046530)3.83278945
23eye photoreceptor cell differentiation (GO:0001754)3.83278945
24nucleoside diphosphate phosphorylation (GO:0006165)3.83208123
25sequestering of actin monomers (GO:0042989)3.81774528
26regulation of cilium movement (GO:0003352)3.77317454
27chaperone-mediated protein transport (GO:0072321)3.69662466
28centriole assembly (GO:0098534)3.65853200
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.65299312
30regulation of female gonad development (GO:2000194)3.64712814
31negative regulation of protein localization to cell surface (GO:2000009)3.63047790
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.58549998
33ATP synthesis coupled proton transport (GO:0015986)3.58549998
34limb bud formation (GO:0060174)3.57569206
35microtubule severing (GO:0051013)3.57161067
36* cilium morphogenesis (GO:0060271)3.56150242
37behavioral response to nicotine (GO:0035095)3.55397963
38protein polyglutamylation (GO:0018095)3.43100529
39left/right axis specification (GO:0070986)3.40210513
40regulation of mitochondrial translation (GO:0070129)3.36304733
41guanosine-containing compound biosynthetic process (GO:1901070)3.34644258
42water-soluble vitamin biosynthetic process (GO:0042364)3.34145883
43positive regulation of actin filament depolymerization (GO:0030836)3.31491884
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27755557
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27755557
46inner mitochondrial membrane organization (GO:0007007)3.21110446
47UTP metabolic process (GO:0046051)3.20778723
48myelination (GO:0042552)3.20614770
49axon ensheathment (GO:0008366)3.17693392
50ensheathment of neurons (GO:0007272)3.17693392
51fusion of sperm to egg plasma membrane (GO:0007342)3.16342928
52cilium assembly (GO:0042384)3.15651137
53cilium organization (GO:0044782)3.13737213
54proteasome assembly (GO:0043248)3.12716683
55male meiosis (GO:0007140)3.11722890
56respiratory electron transport chain (GO:0022904)3.11600354
57respiratory chain complex IV assembly (GO:0008535)3.11280484
58fatty acid elongation (GO:0030497)3.09059167
59electron transport chain (GO:0022900)3.07645772
60platelet dense granule organization (GO:0060155)3.06015436
61aldehyde catabolic process (GO:0046185)3.03041478
62cytochrome complex assembly (GO:0017004)3.00053733
63CTP metabolic process (GO:0046036)2.98078820
64CTP biosynthetic process (GO:0006241)2.98078820
65viral transcription (GO:0019083)2.95489956
66otic vesicle formation (GO:0030916)2.95041935
67response to redox state (GO:0051775)2.94939598
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94661079
69cotranslational protein targeting to membrane (GO:0006613)2.94427415
70hydrogen ion transmembrane transport (GO:1902600)2.93798649
71intracellular protein transmembrane import (GO:0044743)2.92621393
72multicellular organism reproduction (GO:0032504)2.92351102
73regulation of microtubule-based movement (GO:0060632)2.92229647
74microtubule bundle formation (GO:0001578)2.92058670
75translational termination (GO:0006415)2.91986080
76ATP biosynthetic process (GO:0006754)2.91504565
77cullin deneddylation (GO:0010388)2.89611166
78protein targeting to ER (GO:0045047)2.89099301
79microtubule polymerization or depolymerization (GO:0031109)2.85336665
80pyrimidine nucleobase catabolic process (GO:0006208)2.85288979
81ventricular system development (GO:0021591)2.85087074
82single fertilization (GO:0007338)2.84725815
83cellular component assembly involved in morphogenesis (GO:0010927)2.83891745
84notochord development (GO:0030903)2.82615035
85regulation of cardioblast differentiation (GO:0051890)2.82047875
86mannosylation (GO:0097502)2.79824323
87protein localization to endoplasmic reticulum (GO:0070972)2.77953364
88protein deneddylation (GO:0000338)2.77615298
89establishment of protein localization to endoplasmic reticulum (GO:0072599)2.77546608
90long-chain fatty acid biosynthetic process (GO:0042759)2.77231764
91proton transport (GO:0015992)2.73888801
92nonmotile primary cilium assembly (GO:0035058)2.71254786
93hydrogen transport (GO:0006818)2.68170002
94ribosomal small subunit assembly (GO:0000028)2.67076402
95lateral sprouting from an epithelium (GO:0060601)2.60038087
96neuron fate determination (GO:0048664)2.58382882
97ribonucleoside triphosphate biosynthetic process (GO:0009201)2.57557733
98DNA methylation involved in gamete generation (GO:0043046)2.56416579
99isoprenoid biosynthetic process (GO:0008299)2.56133609
100smoothened signaling pathway (GO:0007224)2.55953277
101NADH dehydrogenase complex assembly (GO:0010257)2.54705141
102mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54705141
103mitochondrial respiratory chain complex I assembly (GO:0032981)2.54705141
104nucleoside triphosphate biosynthetic process (GO:0009142)2.54093714
105female gonad development (GO:0008585)2.53748711
106oligodendrocyte differentiation (GO:0048709)2.53485060
107meiotic cell cycle (GO:0051321)2.52718691
108determination of bilateral symmetry (GO:0009855)2.52189044
109sperm motility (GO:0030317)2.51936141
110cardiac epithelial to mesenchymal transition (GO:0060317)2.51624390
111negative regulation of execution phase of apoptosis (GO:1900118)2.50592224
112DNA damage response, detection of DNA damage (GO:0042769)2.50398249
113specification of symmetry (GO:0009799)2.49499321
114negative regulation of smooth muscle cell differentiation (GO:0051151)2.49197866
115translational elongation (GO:0006414)2.49057370
116fertilization (GO:0009566)2.48495783
117heart valve formation (GO:0003188)2.48132924
118protein localization to mitochondrion (GO:0070585)2.47418625
119pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.47270552
120retinal ganglion cell axon guidance (GO:0031290)2.46686678
121protein targeting to mitochondrion (GO:0006626)2.46046040
122glycerophospholipid catabolic process (GO:0046475)2.45378726
123establishment of protein localization to mitochondrion (GO:0072655)2.45132111
124acrosome reaction (GO:0007340)2.43720990
125purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.43645117
126cellular response to gamma radiation (GO:0071480)2.42305157
127epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.41958441
128positive regulation of meiosis (GO:0045836)2.41773326
129positive regulation of gastrulation (GO:2000543)2.41496863
130transcription elongation from RNA polymerase III promoter (GO:0006385)2.41349147
131termination of RNA polymerase III transcription (GO:0006386)2.41349147
132retinal rod cell development (GO:0046548)2.40488696
133substantia nigra development (GO:0021762)2.40112034
134regulation of meiosis (GO:0040020)2.38553229
135myelin maintenance (GO:0043217)2.38486201
136positive regulation of protein depolymerization (GO:1901881)2.38339966
137nucleobase catabolic process (GO:0046113)2.37054972
138purine nucleoside triphosphate biosynthetic process (GO:0009145)2.36289933
139negative regulation of myoblast differentiation (GO:0045662)2.36080236
140viral life cycle (GO:0019058)2.35310953
141positive regulation of meiotic cell cycle (GO:0051446)2.34045320
142protein complex biogenesis (GO:0070271)2.33386705
143plasma membrane fusion (GO:0045026)2.33262072
144photoreceptor cell maintenance (GO:0045494)2.32977381
145nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.32921231
146glutathione derivative metabolic process (GO:1901685)2.32602610
147glutathione derivative biosynthetic process (GO:1901687)2.32602610
148protein-cofactor linkage (GO:0018065)2.31980591
149cellular protein complex disassembly (GO:0043624)2.30594652
150response to pheromone (GO:0019236)2.30271357
151sensory perception of chemical stimulus (GO:0007606)2.30149386
152determination of left/right symmetry (GO:0007368)2.29766093
153regulation of meiosis I (GO:0060631)2.29617238
154mesenchyme morphogenesis (GO:0072132)2.26656520
155apical protein localization (GO:0045176)2.26163198
156olfactory bulb development (GO:0021772)2.25773031
157mesenchymal cell proliferation (GO:0010463)2.24692938

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.02509859
2EST1_17652178_ChIP-ChIP_JURKAT_Human2.97859191
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.88543125
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48670247
5BMI1_23680149_ChIP-Seq_NPCS_Mouse2.44731156
6ZNF274_21170338_ChIP-Seq_K562_Hela2.38420558
7VDR_22108803_ChIP-Seq_LS180_Human2.34908043
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.20964328
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.20789369
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20786394
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03265388
12RNF2_27304074_Chip-Seq_NSC_Mouse1.95421831
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94304149
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93815474
15CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91468503
16GATA1_26923725_Chip-Seq_HPCs_Mouse1.89989602
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84317021
18GBX2_23144817_ChIP-Seq_PC3_Human1.83427503
19ELK1_19687146_ChIP-ChIP_HELA_Human1.82626566
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78230114
21EZH2_22144423_ChIP-Seq_EOC_Human1.76813782
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.72887528
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.67241320
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67019754
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63803216
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.62138326
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60844584
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.60606749
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60462714
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59342221
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.58796539
32TAF15_26573619_Chip-Seq_HEK293_Human1.57861272
33VDR_23849224_ChIP-Seq_CD4+_Human1.54967724
34* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54897506
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52350253
36FUS_26573619_Chip-Seq_HEK293_Human1.51746839
37LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50861057
38ER_23166858_ChIP-Seq_MCF-7_Human1.49375353
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49333769
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48311851
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47007569
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46127458
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46028459
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44368774
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43487159
46MYC_18940864_ChIP-ChIP_HL60_Human1.42990839
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42048714
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.41085175
49IGF1R_20145208_ChIP-Seq_DFB_Human1.38308894
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31242412
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31242412
52P300_19829295_ChIP-Seq_ESCs_Human1.30903002
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30071434
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30013464
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29642681
56KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29597486
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29471120
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29346192
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29077832
60GABP_19822575_ChIP-Seq_HepG2_Human1.28690624
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27791187
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27544255
63KAP1_22055183_ChIP-Seq_ESCs_Mouse1.26716569
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26565400
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26093397
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.25309116
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.23808273
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22591576
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22157033
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.21954845
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.21311347
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21076426
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19321384
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.19067365
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18313933
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18271089
77WT1_19549856_ChIP-ChIP_CCG9911_Human1.17561886
78TTF2_22483619_ChIP-Seq_HELA_Human1.17430072
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17249215
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17072124
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16624309
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15935829
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15405908
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14885484
85TP53_22573176_ChIP-Seq_HFKS_Human1.14798296
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13966286
87CJUN_26792858_Chip-Seq_BT549_Human1.13290722
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13252807
89CBP_20019798_ChIP-Seq_JUKART_Human1.13249060
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13249060
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13146110
92SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12655612
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12214585
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12172289
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11184505
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10858531
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10498669
98SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10287152
99IRF1_19129219_ChIP-ChIP_H3396_Human1.10170167
100RNF2_27304074_Chip-Seq_ESCs_Mouse1.09561909
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09031004
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08808784
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08783770
104YY1_21170310_ChIP-Seq_MESCs_Mouse1.08297942
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08001331
106REST_21632747_ChIP-Seq_MESCs_Mouse1.07169952
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.06128790
108HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05697021
109ELK1_22589737_ChIP-Seq_MCF10A_Human1.04660086
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04332442
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03888919
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03601233
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02660416
114FOXP3_21729870_ChIP-Seq_TREG_Human1.01901597
115SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01651778
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00661851
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99838243
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99000268
119SMAD3_21741376_ChIP-Seq_EPCs_Human0.98844550
120FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97671038
121FOXA1_25329375_ChIP-Seq_VCAP_Human0.97671038
122SOX2_16153702_ChIP-ChIP_HESCs_Human0.97457353
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96989839
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96989839
125MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96701236
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96373535
127FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96352896
128SOX2_19829295_ChIP-Seq_ESCs_Human0.96324929
129NANOG_19829295_ChIP-Seq_ESCs_Human0.96324929
130SMAD_19615063_ChIP-ChIP_OVARY_Human0.96214620
131SMAD4_21799915_ChIP-Seq_A2780_Human0.95520226
132AR_20517297_ChIP-Seq_VCAP_Human0.95402382
133EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94619486
134STAT3_18555785_Chip-Seq_ESCs_Mouse0.94619458
135GF1B_26923725_Chip-Seq_HPCs_Mouse0.94491215
136CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94410623
137AR_25329375_ChIP-Seq_VCAP_Human0.94316956
138SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93895187
139P53_22387025_ChIP-Seq_ESCs_Mouse0.93812614
140DCP1A_22483619_ChIP-Seq_HELA_Human0.93141606
141NCOR_22424771_ChIP-Seq_293T_Human0.93057502
142STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93030786
143BCAT_22108803_ChIP-Seq_LS180_Human0.92698296
144SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92469687
145EWS_26573619_Chip-Seq_HEK293_Human0.92468873
146SALL1_21062744_ChIP-ChIP_HESCs_Human0.91766369
147CMYC_18555785_Chip-Seq_ESCs_Mouse0.91072843
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90770571
149E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90625895
150STAT1_17558387_ChIP-Seq_HELA_Human0.89893575
151CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89263689
152KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88853535
153MYC_18358816_ChIP-ChIP_MESCs_Mouse0.87622065
154CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86229422
155XRN2_22483619_ChIP-Seq_HELA_Human0.85938994

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.71229844
2MP0000566_synostosis3.26988994
3MP0003950_abnormal_plasma_membrane2.81249738
4MP0005410_abnormal_fertilization2.74728657
5MP0001984_abnormal_olfaction2.70191341
6MP0010030_abnormal_orbit_morphology2.66813661
7MP0002102_abnormal_ear_morphology2.62226715
8MP0002653_abnormal_ependyma_morphology2.52971372
9MP0003937_abnormal_limbs/digits/tail_de2.18680360
10MP0009250_abnormal_appendicular_skeleto2.16906067
11MP0005451_abnormal_body_composition2.11797759
12MP0005171_absent_coat_pigmentation2.06320192
13MP0003718_maternal_effect2.03466654
14MP0005623_abnormal_meninges_morphology1.98796728
15MP0003122_maternal_imprinting1.97083712
16MP0003011_delayed_dark_adaptation1.89160435
17MP0008789_abnormal_olfactory_epithelium1.88286372
18MP0002249_abnormal_larynx_morphology1.88061903
19MP0002282_abnormal_trachea_morphology1.79075538
20MP0006276_abnormal_autonomic_nervous1.74310433
21MP0000049_abnormal_middle_ear1.73763691
22MP0001529_abnormal_vocalization1.73466962
23MP0002837_dystrophic_cardiac_calcinosis1.73068946
24MP0009379_abnormal_foot_pigmentation1.71574183
25MP0001905_abnormal_dopamine_level1.68702319
26MP0001485_abnormal_pinna_reflex1.68635425
27MP0001346_abnormal_lacrimal_gland1.68140553
28MP0002938_white_spotting1.67895119
29MP0000762_abnormal_tongue_morphology1.66008518
30MP0004133_heterotaxia1.64649216
31MP0000778_abnormal_nervous_system1.64586900
32MP0009384_cardiac_valve_regurgitation1.62018260
33MP0005084_abnormal_gallbladder_morpholo1.61542736
34MP0004134_abnormal_chest_morphology1.56045948
35MP0002234_abnormal_pharynx_morphology1.55130034
36MP0002822_catalepsy1.50190348
37MP0004142_abnormal_muscle_tone1.48479531
38MP0008877_abnormal_DNA_methylation1.46231412
39MP0005408_hypopigmentation1.45374140
40MP0000749_muscle_degeneration1.45038807
41MP0000920_abnormal_myelination1.44488267
42MP0002233_abnormal_nose_morphology1.40184408
43MP0003646_muscle_fatigue1.37203604
44MP0009046_muscle_twitch1.35656809
45MP0008875_abnormal_xenobiotic_pharmacok1.35578455
46MP0003755_abnormal_palate_morphology1.34147708
47MP0008995_early_reproductive_senescence1.33133975
48MP0004272_abnormal_basement_membrane1.31704638
49MP0002928_abnormal_bile_duct1.31647501
50MP0003186_abnormal_redox_activity1.31083237
51MP0003787_abnormal_imprinting1.27636146
52MP0006292_abnormal_olfactory_placode1.27613587
53MP0000462_abnormal_digestive_system1.25072334
54MP0003938_abnormal_ear_development1.24962881
55MP0005551_abnormal_eye_electrophysiolog1.24868203
56MP0003942_abnormal_urinary_system1.24117391
57MP0002277_abnormal_respiratory_mucosa1.23548726
58MP0002295_abnormal_pulmonary_circulatio1.21502753
59MP0003315_abnormal_perineum_morphology1.21139290
60MP0000372_irregular_coat_pigmentation1.21077074
61MP0001929_abnormal_gametogenesis1.20501766
62MP0002752_abnormal_somatic_nervous1.18390876
63MP0003385_abnormal_body_wall1.17994425
64MP0004742_abnormal_vestibular_system1.17779894
65MP0008932_abnormal_embryonic_tissue1.17551811
66MP0002736_abnormal_nociception_after1.17269372
67MP0002163_abnormal_gland_morphology1.16113723
68MP0004381_abnormal_hair_follicle1.15724929
69MP0000026_abnormal_inner_ear1.15540333
70MP0003698_abnormal_male_reproductive1.15296659
71MP0005508_abnormal_skeleton_morphology1.15052145
72MP0008058_abnormal_DNA_repair1.14702240
73MP0009745_abnormal_behavioral_response1.13924133
74MP0000516_abnormal_urinary_system1.13801919
75MP0005367_renal/urinary_system_phenotyp1.13801919
76MP0002210_abnormal_sex_determination1.12863415
77MP0003890_abnormal_embryonic-extraembry1.11370814
78MP0002272_abnormal_nervous_system1.11362696
79MP0002557_abnormal_social/conspecific_i1.10534702
80MP0001299_abnormal_eye_distance/1.10017917
81MP0005646_abnormal_pituitary_gland1.09494327
82MP0001968_abnormal_touch/_nociception1.09414306
83MP0001542_abnormal_bone_strength1.09115954
84MP0005499_abnormal_olfactory_system1.08167223
85MP0005394_taste/olfaction_phenotype1.08167223
86MP0002160_abnormal_reproductive_system1.07882651
87MP0002876_abnormal_thyroid_physiology1.07744082
88MP0003880_abnormal_central_pattern1.06617306
89MP0004036_abnormal_muscle_relaxation1.05951010
90MP0004145_abnormal_muscle_electrophysio1.05804731
91MP0000534_abnormal_ureter_morphology1.04031844
92MP0005423_abnormal_somatic_nervous1.03865287
93MP0006072_abnormal_retinal_apoptosis1.02475662
94MP0002572_abnormal_emotion/affect_behav1.02336793
95MP0001486_abnormal_startle_reflex1.00264500
96MP0005195_abnormal_posterior_eye0.99890818
97MP0010368_abnormal_lymphatic_system0.99181198
98MP0009780_abnormal_chondrocyte_physiolo0.97016791
99MP0003941_abnormal_skin_development0.96719571
100MP0005391_vision/eye_phenotype0.95672006
101MP0000537_abnormal_urethra_morphology0.95264837
102MP0002116_abnormal_craniofacial_bone0.95199160
103MP0001293_anophthalmia0.95030497
104MP0005248_abnormal_Harderian_gland0.94280822
105MP0005379_endocrine/exocrine_gland_phen0.93386356
106MP0003634_abnormal_glial_cell0.92819251
107MP0001324_abnormal_eye_pigmentation0.90876887
108MP0005395_other_phenotype0.88955081
109MP0000653_abnormal_sex_gland0.88907603
110MP0005645_abnormal_hypothalamus_physiol0.88424679
111MP0002127_abnormal_cardiovascular_syste0.88334756
112MP0000955_abnormal_spinal_cord0.88070794
113MP0005503_abnormal_tendon_morphology0.87959659
114MP0002638_abnormal_pupillary_reflex0.86663582
115MP0001963_abnormal_hearing_physiology0.86479003
116MP0002734_abnormal_mechanical_nocicepti0.86263690
117MP0001986_abnormal_taste_sensitivity0.85033586
118MP0005377_hearing/vestibular/ear_phenot0.84848731
119MP0003878_abnormal_ear_physiology0.84848731
120MP0000538_abnormal_urinary_bladder0.84451084
121MP0003283_abnormal_digestive_organ0.84437238
122MP0001970_abnormal_pain_threshold0.84330929
123MP0002751_abnormal_autonomic_nervous0.84025740
124MP0001286_abnormal_eye_development0.84001608
125MP0000631_abnormal_neuroendocrine_gland0.83502007
126MP0010386_abnormal_urinary_bladder0.83165459
127MP0002882_abnormal_neuron_morphology0.81774964
128MP0004043_abnormal_pH_regulation0.81756655
129MP0004084_abnormal_cardiac_muscle0.81282670
130MP0003861_abnormal_nervous_system0.81218126
131MP0000163_abnormal_cartilage_morphology0.81031882
132MP0005253_abnormal_eye_physiology0.80801700
133MP0005389_reproductive_system_phenotype0.80144328
134MP0004019_abnormal_vitamin_homeostasis0.79259188
135MP0002735_abnormal_chemical_nociception0.78891091
136MP0002109_abnormal_limb_morphology0.78248135
137MP0006036_abnormal_mitochondrial_physio0.77618040
138MP0003786_premature_aging0.77520597
139MP0002909_abnormal_adrenal_gland0.77265507
140MP0000383_abnormal_hair_follicle0.76740756
141MP0002161_abnormal_fertility/fecundity0.74650690
142MP0001145_abnormal_male_reproductive0.74122987
143MP0002184_abnormal_innervation0.73404518
144MP0003137_abnormal_impulse_conducting0.73065026
145MP0003935_abnormal_craniofacial_develop0.72833993
146MP0000432_abnormal_head_morphology0.72776968
147MP0003121_genomic_imprinting0.72692509
148MP0004270_analgesia0.71901993
149MP0000428_abnormal_craniofacial_morphol0.71721859

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.27635403
2Abnormal respiratory motile cilium physiology (HP:0012261)6.37875429
3Abnormal ciliary motility (HP:0012262)5.93360604
4Rhinitis (HP:0012384)5.23683768
5Abnormal respiratory motile cilium morphology (HP:0005938)5.03351397
6Abnormal respiratory epithelium morphology (HP:0012253)5.03351397
7Absent/shortened dynein arms (HP:0200106)4.26196796
8Dynein arm defect of respiratory motile cilia (HP:0012255)4.26196796
9Chronic bronchitis (HP:0004469)3.55027137
10True hermaphroditism (HP:0010459)3.28332237
11Medial flaring of the eyebrow (HP:0010747)3.27385196
12Adrenal hypoplasia (HP:0000835)3.20924131
13Acute necrotizing encephalopathy (HP:0006965)3.17041133
14Hepatic necrosis (HP:0002605)3.16225936
15Congenital primary aphakia (HP:0007707)3.14562073
16Pancreatic fibrosis (HP:0100732)3.13189073
17Gait imbalance (HP:0002141)3.09897363
18Vaginal atresia (HP:0000148)3.03993548
19Genital tract atresia (HP:0001827)2.99468989
20Chronic hepatic failure (HP:0100626)2.81753370
21Nephrogenic diabetes insipidus (HP:0009806)2.79241639
223-Methylglutaconic aciduria (HP:0003535)2.77379260
23Pancreatic cysts (HP:0001737)2.67046172
24Abnormal mitochondria in muscle tissue (HP:0008316)2.60989866
25Aplasia involving bones of the extremities (HP:0009825)2.59490891
26Aplasia involving bones of the upper limbs (HP:0009823)2.59490891
27Aplasia of the phalanges of the hand (HP:0009802)2.59490891
28Cerebral edema (HP:0002181)2.58344951
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.55235642
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.55235642
31Male infertility (HP:0003251)2.50202296
32Progressive macrocephaly (HP:0004481)2.48923543
33Parakeratosis (HP:0001036)2.47124453
34Abnormality of the labia minora (HP:0012880)2.45316696
35Bronchiectasis (HP:0002110)2.45165230
36Degeneration of the lateral corticospinal tracts (HP:0002314)2.39869539
37Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39869539
38Aplasia/Hypoplasia of the lens (HP:0008063)2.38728299
39Molar tooth sign on MRI (HP:0002419)2.38038384
40Abnormality of midbrain morphology (HP:0002418)2.38038384
41Mitochondrial inheritance (HP:0001427)2.36081429
42Acute encephalopathy (HP:0006846)2.35623002
43Poor coordination (HP:0002370)2.35347698
44Occipital encephalocele (HP:0002085)2.34741349
45Retinal dysplasia (HP:0007973)2.33900740
46Polyphagia (HP:0002591)2.32961837
47Supernumerary spleens (HP:0009799)2.26867576
48Tubulointerstitial nephritis (HP:0001970)2.23714701
49* Nephronophthisis (HP:0000090)2.17498313
50Hyperglycinemia (HP:0002154)2.16125498
51Renal Fanconi syndrome (HP:0001994)2.12493611
52Abnormal number of erythroid precursors (HP:0012131)2.11781335
53Nasolacrimal duct obstruction (HP:0000579)2.08608935
54Increased intramyocellular lipid droplets (HP:0012240)2.08282769
55Lactic acidosis (HP:0003128)2.07414881
56Leukodystrophy (HP:0002415)2.06848818
57Methylmalonic acidemia (HP:0002912)2.06684909
58Respiratory failure (HP:0002878)2.04555344
59Sensory axonal neuropathy (HP:0003390)2.04411258
60Preaxial hand polydactyly (HP:0001177)2.04366686
61Abnormality of the middle phalanges of the toes (HP:0010183)2.03767626
62Postaxial hand polydactyly (HP:0001162)2.02713347
63Myokymia (HP:0002411)2.01504805
64Abnormal biliary tract physiology (HP:0012439)2.00652427
65Bile duct proliferation (HP:0001408)2.00652427
66Infertility (HP:0000789)2.00613503
67Chronic sinusitis (HP:0011109)2.00219593
68Aplasia/Hypoplasia of the tongue (HP:0010295)1.99723998
69Stenosis of the external auditory canal (HP:0000402)1.99152380
70Abnormality of incisor morphology (HP:0011063)1.98932827
71Abnormality of the lacrimal duct (HP:0011481)1.98705059
72Increased hepatocellular lipid droplets (HP:0006565)1.98386943
73Abnormality of cells of the erythroid lineage (HP:0012130)1.98148816
74Postaxial foot polydactyly (HP:0001830)1.97555785
75Abnormality of the renal cortex (HP:0011035)1.94840308
76Alacrima (HP:0000522)1.94763182
77Increased serum lactate (HP:0002151)1.93914491
78* Abnormality of dentin (HP:0010299)1.90732698
79Anencephaly (HP:0002323)1.89845780
80* Abnormality of the renal medulla (HP:0100957)1.89129970
81Methylmalonic aciduria (HP:0012120)1.88905887
82Aplasia/Hypoplasia of the tibia (HP:0005772)1.88518146
83Abnormality of the nasolacrimal system (HP:0000614)1.88458251
84Bifid tongue (HP:0010297)1.87889470
85Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.87715369
86Optic disc pallor (HP:0000543)1.87663917
87Male pseudohermaphroditism (HP:0000037)1.86437680
88Abnormality of macular pigmentation (HP:0008002)1.83979226
89Median cleft lip (HP:0000161)1.83865457
90Furrowed tongue (HP:0000221)1.83808909
91Decreased testicular size (HP:0008734)1.83661315
92Tubular atrophy (HP:0000092)1.81817466
93Left ventricular hypertrophy (HP:0001712)1.81719441
94Abnormal rod and cone electroretinograms (HP:0008323)1.81135615
95Abnormality of glycolysis (HP:0004366)1.80919535
96Increased serum pyruvate (HP:0003542)1.80919535
97Flat capital femoral epiphysis (HP:0003370)1.78994307
98Absent septum pellucidum (HP:0001331)1.78002213
99Type II lissencephaly (HP:0007260)1.77547936
100Increased CSF lactate (HP:0002490)1.77238368
101Oculomotor apraxia (HP:0000657)1.76822285
102Facial cleft (HP:0002006)1.75194465
103Hypoplastic left heart (HP:0004383)1.74606632
104Glycosuria (HP:0003076)1.74104943
105Abnormality of urine glucose concentration (HP:0011016)1.74104943
106Partial duplication of thumb phalanx (HP:0009944)1.73976523
107Popliteal pterygium (HP:0009756)1.73222891
108Sclerocornea (HP:0000647)1.72353430
109Bell-shaped thorax (HP:0001591)1.71580313
110Narrow forehead (HP:0000341)1.71537268
111Retinitis pigmentosa (HP:0000510)1.71337367
112Short tibia (HP:0005736)1.71272307
113Exercise intolerance (HP:0003546)1.71164483
114Cerebral hypomyelination (HP:0006808)1.71091544
115Aganglionic megacolon (HP:0002251)1.70567535
116Short hallux (HP:0010109)1.69806972
117Increased muscle lipid content (HP:0009058)1.68885594
118Lethargy (HP:0001254)1.68101867
119Abnormality of the septum pellucidum (HP:0007375)1.67846745
120Hypoplastic pelvis (HP:0008839)1.67797320
121Poor suck (HP:0002033)1.67794934
122Hepatocellular necrosis (HP:0001404)1.67728163
123Specific learning disability (HP:0001328)1.67409176
124Septo-optic dysplasia (HP:0100842)1.66478215
125Symphalangism affecting the phalanges of the hand (HP:0009773)1.65988058
126Partial duplication of the phalanx of hand (HP:0009999)1.65248065
127Broad foot (HP:0001769)1.65068844
128Congenital stationary night blindness (HP:0007642)1.65060157
129Anophthalmia (HP:0000528)1.63699069
130Hypoplastic heart (HP:0001961)1.63488394
131Atelectasis (HP:0100750)1.63485898
132Congenital hepatic fibrosis (HP:0002612)1.62737404
133Optic nerve coloboma (HP:0000588)1.61766287
134Lipid accumulation in hepatocytes (HP:0006561)1.61656131
135Bony spicule pigmentary retinopathy (HP:0007737)1.61623202
136Exertional dyspnea (HP:0002875)1.61424983
137Double outlet right ventricle (HP:0001719)1.60889808
138Congenital malformation of the right heart (HP:0011723)1.60889808
139Concave nail (HP:0001598)1.60071933
140Polydipsia (HP:0001959)1.59664124
141Abnormal drinking behavior (HP:0030082)1.59664124
142Aplasia of the musculature (HP:0100854)1.57560828
143Abnormality of renal resorption (HP:0011038)1.56949866
144Cystic liver disease (HP:0006706)1.56486360
145Abnormality of the fetal cardiovascular system (HP:0010948)1.55530865
146Single umbilical artery (HP:0001195)1.55530865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.23887246
2MAP4K23.31559865
3PBK3.24836695
4STK163.22719104
5STK38L3.06525244
6VRK22.98505439
7LIMK12.87825093
8WNK32.78779759
9PLK42.61181881
10ARAF2.60676994
11BCR2.49208557
12MAP3K122.19985024
13BCKDK2.13419869
14MUSK2.12896958
15MAP3K42.11752241
16BUB12.09714142
17WNK42.02347435
18FRK1.88450223
19OXSR11.87953616
20BRAF1.87873655
21DYRK21.87053385
22TESK11.84982700
23MYLK1.81336243
24MAP2K71.81333076
25BMPR21.74526111
26MARK11.73218094
27MAPKAPK51.71387316
28ERBB41.71204366
29BMPR1B1.64363519
30LATS21.60911443
31MAPK151.59031096
32MST41.57167848
33OBSCN1.52793503
34LATS11.50175367
35MOS1.48616477
36TNIK1.45410675
37DYRK31.43597756
38EPHB21.39936935
39MET1.37699111
40PKN11.35099041
41TLK11.31478693
42PHKG21.30208108
43PHKG11.30208108
44CASK1.25458805
45PRKD31.23290995
46ROCK21.23181834
47ADRBK21.21985674
48INSRR1.20481697
49NEK61.18729127
50CDK81.18069810
51FGFR21.14468477
52EPHA41.14413349
53ZAK1.14080992
54TRPM71.13282300
55TRIM281.09014092
56NME21.08102477
57ERBB31.06925332
58TGFBR11.06395708
59MAP3K61.03237319
60PAK31.02217085
61SRPK11.02123947
62MAPK131.00084521
63PDK20.99779019
64LMTK20.94680571
65PTK2B0.94541707
66PRKCG0.94000909
67CAMK2B0.92991586
68CAMK2D0.92487189
69TIE10.91837049
70CSNK1G30.91085455
71PLK20.89017861
72CDK190.87230813
73STK240.84314268
74SGK2230.83126294
75SGK4940.83126294
76WNK10.82729461
77AURKA0.82226284
78ABL20.82179455
79PNCK0.81617641
80PIM20.80139491
81TYRO30.79947630
82ROCK10.79780898
83ICK0.79586239
84CSNK1A1L0.79007352
85NTRK20.78675950
86TTK0.77104101
87ILK0.76702907
88ACVR1B0.75644413
89CSNK1G10.75043386
90PLK30.74732400
91NME10.73663103
92MAP2K40.73162547
93CAMK2G0.70064864
94IRAK10.69573748
95CAMK2A0.69205343
96PLK10.69129267
97TESK20.66939640
98TAF10.66088001
99EIF2AK10.65558433
100NUAK10.64938570
101PAK10.63695768
102MELK0.62188943
103PASK0.61028419
104CDK30.59734493
105NEK10.59506242
106PDK30.59132913
107PDK40.59132913
108MINK10.57257117
109ADRBK10.56608172
110PRKCE0.56466502
111RPS6KA50.55544358
112PRKCI0.55357763
113EPHA20.55081702
114CHEK20.55002071
115GRK10.54728262
116CCNB10.53541082
117GRK50.51190902
118VRK10.50829118
119AKT30.49304799
120CDK140.48177826
121EIF2AK30.47381600
122PRKACA0.47109211
123STK30.45734965
124FGR0.45138151
125CSNK1A10.43936982
126WEE10.43920015
127PIK3CA0.42843230
128CDK180.42665807
129NTRK30.42145260
130TAOK30.41845383
131CDK90.41818419
132EPHB10.40836750
133CSNK2A10.40829813
134MAPKAPK30.39620031
135CSNK2A20.39304240
136CDK150.38944216
137CSNK1G20.38687902
138AURKB0.37782110
139MAP3K110.36938870
140UHMK10.35871372
141EPHA30.33426577
142CDK11A0.33147167
143DAPK30.31896513
144PINK10.31609218

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.28841902
2Parkinsons disease_Homo sapiens_hsa050123.61881420
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.25671897
4Huntingtons disease_Homo sapiens_hsa050163.24428451
5Alzheimers disease_Homo sapiens_hsa050102.72336550
6Proteasome_Homo sapiens_hsa030502.46619610
7Basal transcription factors_Homo sapiens_hsa030222.42340074
8Protein export_Homo sapiens_hsa030602.41463184
9Ether lipid metabolism_Homo sapiens_hsa005652.33795752
10Cardiac muscle contraction_Homo sapiens_hsa042602.22884179
11Steroid biosynthesis_Homo sapiens_hsa001002.21866739
12RNA polymerase_Homo sapiens_hsa030202.16930801
13Phototransduction_Homo sapiens_hsa047442.14713521
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.09375657
15Linoleic acid metabolism_Homo sapiens_hsa005911.91732283
16Arachidonic acid metabolism_Homo sapiens_hsa005901.90765211
17Fatty acid elongation_Homo sapiens_hsa000621.80878018
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74962523
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73770121
20Butanoate metabolism_Homo sapiens_hsa006501.72163302
21Olfactory transduction_Homo sapiens_hsa047401.68127994
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68038536
23Vitamin B6 metabolism_Homo sapiens_hsa007501.57677825
24Sulfur metabolism_Homo sapiens_hsa009201.57215753
25Sphingolipid metabolism_Homo sapiens_hsa006001.50391499
26Ribosome_Homo sapiens_hsa030101.49394177
27Sulfur relay system_Homo sapiens_hsa041221.48253262
28Ovarian steroidogenesis_Homo sapiens_hsa049131.45653222
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44604376
30TGF-beta signaling pathway_Homo sapiens_hsa043501.40520926
31Glutathione metabolism_Homo sapiens_hsa004801.38177566
32Folate biosynthesis_Homo sapiens_hsa007901.37257241
33Hedgehog signaling pathway_Homo sapiens_hsa043401.30632475
34Tight junction_Homo sapiens_hsa045301.30341486
35Hippo signaling pathway_Homo sapiens_hsa043901.28962496
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26342825
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.25381759
38RNA degradation_Homo sapiens_hsa030181.22467573
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.16802930
40Nucleotide excision repair_Homo sapiens_hsa034201.16262659
41Basal cell carcinoma_Homo sapiens_hsa052171.14651503
42Purine metabolism_Homo sapiens_hsa002301.13391136
43Axon guidance_Homo sapiens_hsa043601.12130965
44Nicotine addiction_Homo sapiens_hsa050331.11251462
45Collecting duct acid secretion_Homo sapiens_hsa049661.05569136
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05329374
47Rheumatoid arthritis_Homo sapiens_hsa053231.03858464
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01735599
49Mismatch repair_Homo sapiens_hsa034301.01358087
50Pyrimidine metabolism_Homo sapiens_hsa002400.98148464
51Cell cycle_Homo sapiens_hsa041100.95456786
52beta-Alanine metabolism_Homo sapiens_hsa004100.95124769
53Histidine metabolism_Homo sapiens_hsa003400.94186772
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93407839
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93102922
56Dilated cardiomyopathy_Homo sapiens_hsa054140.92462097
57ECM-receptor interaction_Homo sapiens_hsa045120.91833587
58Vibrio cholerae infection_Homo sapiens_hsa051100.90754332
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87140839
60Fanconi anemia pathway_Homo sapiens_hsa034600.87014645
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85957869
62Homologous recombination_Homo sapiens_hsa034400.85941982
63Tryptophan metabolism_Homo sapiens_hsa003800.85500496
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81257354
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80632574
66Phenylalanine metabolism_Homo sapiens_hsa003600.78873613
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.73801824
68Arginine and proline metabolism_Homo sapiens_hsa003300.73794066
69Autoimmune thyroid disease_Homo sapiens_hsa053200.73690970
70Selenocompound metabolism_Homo sapiens_hsa004500.73156186
71Serotonergic synapse_Homo sapiens_hsa047260.72622392
72Regulation of autophagy_Homo sapiens_hsa041400.71339712
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71020928
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70458765
75Fatty acid degradation_Homo sapiens_hsa000710.69892698
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69091687
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.67356371
78Nitrogen metabolism_Homo sapiens_hsa009100.65449321
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64490820
80Notch signaling pathway_Homo sapiens_hsa043300.63499727
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61989207
82Caffeine metabolism_Homo sapiens_hsa002320.61497923
83Metabolic pathways_Homo sapiens_hsa011000.61394335
84Ras signaling pathway_Homo sapiens_hsa040140.60234906
85Wnt signaling pathway_Homo sapiens_hsa043100.59141270
86Renal cell carcinoma_Homo sapiens_hsa052110.56895942
87Fatty acid metabolism_Homo sapiens_hsa012120.56376196
88Malaria_Homo sapiens_hsa051440.55402273
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54466764
90GABAergic synapse_Homo sapiens_hsa047270.54024619
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53683975
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.53428550
93Oocyte meiosis_Homo sapiens_hsa041140.52191805
94Insulin secretion_Homo sapiens_hsa049110.48647185
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48406242
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46892920
97Circadian rhythm_Homo sapiens_hsa047100.46421654
98Chemical carcinogenesis_Homo sapiens_hsa052040.46157383
99Synaptic vesicle cycle_Homo sapiens_hsa047210.45810807
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44967663
101Cocaine addiction_Homo sapiens_hsa050300.44712130
102Spliceosome_Homo sapiens_hsa030400.44320128
103Pyruvate metabolism_Homo sapiens_hsa006200.43917929
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43162037
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40941326
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40213456
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39273891
108Phagosome_Homo sapiens_hsa041450.39107493
109Melanogenesis_Homo sapiens_hsa049160.38575838
110Pathways in cancer_Homo sapiens_hsa052000.38524652
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37994811
112Propanoate metabolism_Homo sapiens_hsa006400.37974166
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37486847
114Non-homologous end-joining_Homo sapiens_hsa034500.37354648
115N-Glycan biosynthesis_Homo sapiens_hsa005100.36902250
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36525401
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35552574
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35439137
119Adherens junction_Homo sapiens_hsa045200.35430178
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35335829
121Carbon metabolism_Homo sapiens_hsa012000.35235370
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35123761
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35055118
124Mineral absorption_Homo sapiens_hsa049780.34895816
125One carbon pool by folate_Homo sapiens_hsa006700.34425668
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34298599
127Tyrosine metabolism_Homo sapiens_hsa003500.30372569
128RNA transport_Homo sapiens_hsa030130.28776293
129Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26413556
130Melanoma_Homo sapiens_hsa052180.24770924
131Taste transduction_Homo sapiens_hsa047420.24670896
132Base excision repair_Homo sapiens_hsa034100.23835346
133Peroxisome_Homo sapiens_hsa041460.22015160
134Focal adhesion_Homo sapiens_hsa045100.19740678
135MicroRNAs in cancer_Homo sapiens_hsa052060.19472084
136Retinol metabolism_Homo sapiens_hsa008300.19420025
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19398172
138Graft-versus-host disease_Homo sapiens_hsa053320.18293504
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.18189823
140Alcoholism_Homo sapiens_hsa050340.16313784
141Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.16195727
142Prostate cancer_Homo sapiens_hsa052150.15947527

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