IFT46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)5.27261517
2protein deneddylation (GO:0000338)4.74933503
3left/right pattern formation (GO:0060972)4.32199489
4cilium or flagellum-dependent cell motility (GO:0001539)4.13860783
5axonemal dynein complex assembly (GO:0070286)4.08936219
6cilium movement (GO:0003341)4.01705658
7* intraciliary transport (GO:0042073)3.98270729
8epithelial cilium movement (GO:0003351)3.91462527
9piRNA metabolic process (GO:0034587)3.89773548
10regulation of cilium movement (GO:0003352)3.83394364
11left/right axis specification (GO:0070986)3.80145741
12paraxial mesoderm development (GO:0048339)3.47519205
13protein neddylation (GO:0045116)3.46058830
14protein polyglutamylation (GO:0018095)3.44673591
15single strand break repair (GO:0000012)3.38223152
16* cellular component assembly involved in morphogenesis (GO:0010927)3.35056374
17axoneme assembly (GO:0035082)3.33903158
18microtubule depolymerization (GO:0007019)3.33725548
19histone H2A acetylation (GO:0043968)3.33437912
20DNA strand renaturation (GO:0000733)3.28919259
21male meiosis (GO:0007140)3.26196235
22sympathetic nervous system development (GO:0048485)3.22876035
23DNA methylation involved in gamete generation (GO:0043046)3.22087199
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.19132362
25notochord development (GO:0030903)3.18292867
26ubiquinone biosynthetic process (GO:0006744)3.15509442
27motile cilium assembly (GO:0044458)3.13231930
28* microtubule-based movement (GO:0007018)3.02030013
29regulation of microtubule-based movement (GO:0060632)3.00710299
30negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.98523959
31ubiquinone metabolic process (GO:0006743)2.95007977
32cilium morphogenesis (GO:0060271)2.93866722
33protein K6-linked ubiquitination (GO:0085020)2.91754328
34* cilium assembly (GO:0042384)2.88318822
35histone arginine methylation (GO:0034969)2.83726820
36* cilium organization (GO:0044782)2.81640281
37multicellular organism reproduction (GO:0032504)2.81020966
38negative regulation of androgen receptor signaling pathway (GO:0060766)2.77502327
39limb development (GO:0060173)2.75897018
40appendage development (GO:0048736)2.75897018
41microtubule severing (GO:0051013)2.75703174
42positive regulation of gastrulation (GO:2000543)2.72185099
43binding of sperm to zona pellucida (GO:0007339)2.71493030
44limb bud formation (GO:0060174)2.69885526
45DNA integration (GO:0015074)2.69600166
46* cell projection assembly (GO:0030031)2.68636444
47sperm-egg recognition (GO:0035036)2.68425755
48female gonad development (GO:0008585)2.66514433
49DNA ligation (GO:0006266)2.66063259
50nucleoside diphosphate phosphorylation (GO:0006165)2.63805145
51* smoothened signaling pathway (GO:0007224)2.63186774
52GTP biosynthetic process (GO:0006183)2.62824331
53viral protein processing (GO:0019082)2.62605541
54respiratory chain complex IV assembly (GO:0008535)2.62289453
55rRNA methylation (GO:0031167)2.61758609
56rRNA modification (GO:0000154)2.61675257
57ganglion development (GO:0061548)2.60238319
58intra-S DNA damage checkpoint (GO:0031573)2.60093045
59quinone biosynthetic process (GO:1901663)2.59856420
60GDP-mannose metabolic process (GO:0019673)2.59617188
61centriole replication (GO:0007099)2.59141851
62regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.57498555
63proteasome assembly (GO:0043248)2.56268122
64DNA damage response, detection of DNA damage (GO:0042769)2.56050964
657-methylguanosine mRNA capping (GO:0006370)2.55953544
66protein K11-linked ubiquitination (GO:0070979)2.55139429
67protein localization to cilium (GO:0061512)2.53779129
68protein-cofactor linkage (GO:0018065)2.53714390
69centriole assembly (GO:0098534)2.53612881
70microtubule polymerization or depolymerization (GO:0031109)2.52861828
71RNA capping (GO:0036260)2.52621981
727-methylguanosine RNA capping (GO:0009452)2.52621981
73nonmotile primary cilium assembly (GO:0035058)2.52126072
74establishment of protein localization to mitochondrial membrane (GO:0090151)2.50141227
75synaptonemal complex organization (GO:0070193)2.49744268
76cytoplasmic microtubule organization (GO:0031122)2.48379619
77determination of left/right symmetry (GO:0007368)2.48302999
78sperm motility (GO:0030317)2.47561468
79single fertilization (GO:0007338)2.47388026
80terpenoid biosynthetic process (GO:0016114)2.46981426
81resolution of meiotic recombination intermediates (GO:0000712)2.45847377
82embryonic digit morphogenesis (GO:0042733)2.44327034
83guanosine-containing compound biosynthetic process (GO:1901070)2.43982695
84presynaptic membrane assembly (GO:0097105)2.43087493
85kinetochore assembly (GO:0051382)2.41352327
86viral mRNA export from host cell nucleus (GO:0046784)2.41327512
87determination of bilateral symmetry (GO:0009855)2.40535003
88negative regulation of signal transduction by p53 class mediator (GO:1901797)2.40272212
89somite rostral/caudal axis specification (GO:0032525)2.39668066
90negative regulation of cytosolic calcium ion concentration (GO:0051481)2.39516741
91specification of symmetry (GO:0009799)2.36986997
92cytochrome complex assembly (GO:0017004)2.36946219
93synaptonemal complex assembly (GO:0007130)2.36788512
94diterpenoid biosynthetic process (GO:0016102)2.34659171
95cell differentiation involved in metanephros development (GO:0072202)2.34134831
96histone H4-K12 acetylation (GO:0043983)2.33779991
97retinal ganglion cell axon guidance (GO:0031290)2.33767804
98aldehyde catabolic process (GO:0046185)2.33293703
99somatic hypermutation of immunoglobulin genes (GO:0016446)2.31374525
100somatic diversification of immune receptors via somatic mutation (GO:0002566)2.31374525
101mitotic metaphase plate congression (GO:0007080)2.31259106
102transcription elongation from RNA polymerase II promoter (GO:0006368)2.31201740
103synapsis (GO:0007129)2.30493492
104presynaptic membrane organization (GO:0097090)2.30178646
105regulation of nuclear cell cycle DNA replication (GO:0033262)2.30058139
106bone trabecula formation (GO:0060346)2.29427705
107regulation of double-strand break repair via homologous recombination (GO:0010569)2.29264421
108regulation of development, heterochronic (GO:0040034)2.28684956
109negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.28625666
110regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.27523321
111regulation of mitotic spindle checkpoint (GO:1903504)2.27523321
112regulation of meiosis I (GO:0060631)2.25744415
113organelle disassembly (GO:1903008)2.25450135
114primary alcohol catabolic process (GO:0034310)2.25410086
115negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.25111140
116peptidyl-histidine modification (GO:0018202)2.24737249
117negative regulation of myoblast differentiation (GO:0045662)2.24562335
118poly(A)+ mRNA export from nucleus (GO:0016973)2.24270181
119lateral sprouting from an epithelium (GO:0060601)2.23831529
120mesenchymal cell differentiation involved in renal system development (GO:2001012)2.23386318
121mesenchymal cell differentiation involved in kidney development (GO:0072161)2.23386318
122L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.21979867
123transcription from RNA polymerase I promoter (GO:0006360)2.21138534
124ventricular system development (GO:0021591)2.21058353
125fertilization (GO:0009566)2.20173725
126C-terminal protein lipidation (GO:0006501)2.19761860
127regulation of mitochondrial translation (GO:0070129)2.19357365
128auditory behavior (GO:0031223)2.19317533
129UTP biosynthetic process (GO:0006228)2.19210008
130glomerulus development (GO:0032835)2.18827108
131transcription elongation from RNA polymerase III promoter (GO:0006385)2.18798977
132termination of RNA polymerase III transcription (GO:0006386)2.18798977
133cell-cell recognition (GO:0009988)2.18796524
134regulation of timing of cell differentiation (GO:0048505)2.18737717
135kidney morphogenesis (GO:0060993)2.18720251
136branched-chain amino acid catabolic process (GO:0009083)2.18649565
137replication fork processing (GO:0031297)2.17632405
138spermatid development (GO:0007286)2.17481523
139anterograde synaptic vesicle transport (GO:0048490)2.17315286
140signal transduction involved in cell cycle checkpoint (GO:0072395)2.17273488
141microtubule bundle formation (GO:0001578)2.17049572
142retinal rod cell development (GO:0046548)2.16340121
143C-terminal protein amino acid modification (GO:0018410)2.16297675
144postsynaptic membrane organization (GO:0001941)2.15527236
145* microtubule-based process (GO:0007017)2.15332569
146mannosylation (GO:0097502)2.11628587
147* organelle assembly (GO:0070925)2.11377723
148protein complex biogenesis (GO:0070271)2.10183816
149preassembly of GPI anchor in ER membrane (GO:0016254)2.09902997
150nucleotide transmembrane transport (GO:1901679)2.07871306
151pyrimidine-containing compound transmembrane transport (GO:0072531)2.05915224
152mechanosensory behavior (GO:0007638)2.04395036
153cornea development in camera-type eye (GO:0061303)2.03140516
154sperm capacitation (GO:0048240)2.02340524
155retinal cone cell development (GO:0046549)1.99892786
156one-carbon compound transport (GO:0019755)1.98125318
157anterograde axon cargo transport (GO:0008089)1.96804221
158positive regulation of calcium ion-dependent exocytosis (GO:0045956)1.95033513
159lipid particle organization (GO:0034389)1.94962480
160* microtubule-based transport (GO:0010970)1.94001069
161regulation of autophagic vacuole assembly (GO:2000785)1.91846612
162mitochondrial respiratory chain complex assembly (GO:0033108)1.91252294
163olfactory bulb development (GO:0021772)1.90465975
164positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)1.89176313
165vitamin transmembrane transport (GO:0035461)1.88751269
166isoprenoid biosynthetic process (GO:0008299)1.88633202
167inositol phosphate catabolic process (GO:0071545)1.88588193
168regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)1.87494225
169establishment of monopolar cell polarity (GO:0061162)1.87142558
170establishment or maintenance of monopolar cell polarity (GO:0061339)1.87142558

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.98221468
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.98014367
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.80332219
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.70062191
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.70062191
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.70062191
7ZNF274_21170338_ChIP-Seq_K562_Hela2.65279993
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.53566102
9BMI1_23680149_ChIP-Seq_NPCS_Mouse2.40522942
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27745705
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26903680
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19291771
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14567040
14VDR_22108803_ChIP-Seq_LS180_Human2.12860642
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.06896231
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.06013225
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.04124438
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.03557242
19EZH2_22144423_ChIP-Seq_EOC_Human1.97943371
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97719365
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90955713
22RNF2_27304074_Chip-Seq_NSC_Mouse1.90868078
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.87083131
24SOX2_18555785_ChIP-Seq_MESCs_Mouse1.86320415
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83203362
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78730450
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76764035
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76351108
29NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.74387675
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70293104
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70262368
32IGF1R_20145208_ChIP-Seq_DFB_Human1.69007779
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.68811319
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68199089
35P300_19829295_ChIP-Seq_ESCs_Human1.66000414
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63169821
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62061648
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59857547
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.59201723
40GBX2_23144817_ChIP-Seq_PC3_Human1.57221487
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56864700
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56240197
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55635570
44IRF1_19129219_ChIP-ChIP_H3396_Human1.54277569
45SMAD4_21799915_ChIP-Seq_A2780_Human1.52431966
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51443233
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51145437
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.50185721
49TAF15_26573619_Chip-Seq_HEK293_Human1.49262288
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47899676
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47569974
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46853581
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46073472
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45863935
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45385173
56TCF3_18692474_ChIP-Seq_MESCs_Mouse1.41441384
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39170505
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38933636
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.38641373
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.38590585
61NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.37370408
62SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.36200583
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32839002
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31824547
65VDR_23849224_ChIP-Seq_CD4+_Human1.31300630
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.29977027
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.29923229
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.28500983
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26696354
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26653949
71FUS_26573619_Chip-Seq_HEK293_Human1.26307217
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26099298
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.25730017
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25471393
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25395807
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24370890
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23651935
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21245706
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21178934
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20542110
81STAT3_23295773_ChIP-Seq_U87_Human1.20092206
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19251775
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18999244
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18275395
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17912542
86SOX2_16153702_ChIP-ChIP_HESCs_Human1.16370523
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16175297
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15910377
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14582980
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12924712
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11106028
92TTF2_22483619_ChIP-Seq_HELA_Human1.11016913
93AR_25329375_ChIP-Seq_VCAP_Human1.10713014
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.10629472
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10505895
96GABP_19822575_ChIP-Seq_HepG2_Human1.10105370
97MYC_18940864_ChIP-ChIP_HL60_Human1.10009566
98DCP1A_22483619_ChIP-Seq_HELA_Human1.09571613
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08577837
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08217512
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.08173235
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07981118
103E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06797392
104POU5F1_16518401_ChIP-PET_MESCs_Mouse1.05806884
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05679049
106TCF4_23295773_ChIP-Seq_U87_Human1.05666001
107EWS_26573619_Chip-Seq_HEK293_Human1.05284094
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04222737
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04021249
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01603143
111TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01478404
112YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01260265
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00986690
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00986690
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00459470
116E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99852394
117BCAT_22108803_ChIP-Seq_LS180_Human0.99075628
118RUNX2_22187159_ChIP-Seq_PCA_Human0.98574404
119TCF4_22108803_ChIP-Seq_LS180_Human0.98095794
120EED_16625203_ChIP-ChIP_MESCs_Mouse0.98051977
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97993936
122SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97565986
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97531268
124FOXP3_21729870_ChIP-Seq_TREG_Human0.97379702
125SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97011124
126LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96421775
127MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95935147
128ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95691112
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95653795
130CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93719989
131SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93500216
132PHF8_20622853_ChIP-Seq_HELA_Human0.92984174
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92952328
134TP53_22573176_ChIP-Seq_HFKS_Human0.91980310
135CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91925817
136TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91773694
137ELK1_19687146_ChIP-ChIP_HELA_Human0.91692649
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91591326
139PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91104857
140SOX2_18692474_ChIP-Seq_MESCs_Mouse0.90752620
141NANOG_18555785_Chip-Seq_ESCs_Mouse0.90633862
142TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90534960
143SOX9_26525672_Chip-Seq_HEART_Mouse0.89866235
144PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89612721
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89407915
146CBP_20019798_ChIP-Seq_JUKART_Human0.89407915
147ER_23166858_ChIP-Seq_MCF-7_Human0.88932288
148FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88890721
149SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88443779
150RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88438321
151NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88373282
152NFE2_27457419_Chip-Seq_LIVER_Mouse0.87193146
153GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87069955
154TBL1_22424771_ChIP-Seq_293T_Human0.87067226
155SOX17_20123909_ChIP-Seq_XEN_Mouse0.87024540
156CBP_21632823_ChIP-Seq_H3396_Human0.86890658
157TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86508351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.63047736
2MP0003136_yellow_coat_color3.53552250
3MP0009780_abnormal_chondrocyte_physiolo3.19982443
4MP0006292_abnormal_olfactory_placode3.09380592
5MP0003880_abnormal_central_pattern2.91531890
6MP0005503_abnormal_tendon_morphology2.70967656
7MP0008789_abnormal_olfactory_epithelium2.31206108
8MP0003787_abnormal_imprinting2.28767127
9MP0003122_maternal_imprinting2.22274822
10MP0003121_genomic_imprinting2.18163080
11MP0004133_heterotaxia2.16477492
12MP0000049_abnormal_middle_ear2.08940527
13MP0005499_abnormal_olfactory_system2.04716651
14MP0005394_taste/olfaction_phenotype2.04716651
15MP0008877_abnormal_DNA_methylation2.01851204
16MP0005623_abnormal_meninges_morphology1.98235963
17MP0008058_abnormal_DNA_repair1.97842371
18MP0001529_abnormal_vocalization1.96275146
19MP0010030_abnormal_orbit_morphology1.84057251
20MP0005410_abnormal_fertilization1.82735647
21MP0003718_maternal_effect1.82013624
22MP0000566_synostosis1.75170178
23MP0002751_abnormal_autonomic_nervous1.75020722
24MP0004043_abnormal_pH_regulation1.71376372
25MP0001188_hyperpigmentation1.69042876
26MP0002938_white_spotting1.69013894
27MP0003693_abnormal_embryo_hatching1.64429890
28MP0003942_abnormal_urinary_system1.64331011
29MP0000678_abnormal_parathyroid_gland1.63737164
30MP0002249_abnormal_larynx_morphology1.61608439
31MP0002837_dystrophic_cardiac_calcinosis1.60083732
32MP0009046_muscle_twitch1.59370180
33MP0002160_abnormal_reproductive_system1.58538312
34MP0002233_abnormal_nose_morphology1.55760613
35MP0000383_abnormal_hair_follicle1.52819293
36MP0003315_abnormal_perineum_morphology1.51856808
37MP0003123_paternal_imprinting1.51240745
38MP0003941_abnormal_skin_development1.51155062
39MP0003937_abnormal_limbs/digits/tail_de1.49650377
40MP0009250_abnormal_appendicular_skeleto1.48157491
41MP0001299_abnormal_eye_distance/1.46210994
42MP0009697_abnormal_copulation1.43107023
43MP0008932_abnormal_embryonic_tissue1.42039216
44MP0000778_abnormal_nervous_system1.41625560
45MP0003890_abnormal_embryonic-extraembry1.40225832
46MP0002163_abnormal_gland_morphology1.39409872
47MP0003938_abnormal_ear_development1.38843471
48MP0001984_abnormal_olfaction1.37607281
49MP0008875_abnormal_xenobiotic_pharmacok1.37044708
50MP0000631_abnormal_neuroendocrine_gland1.34800532
51MP0003755_abnormal_palate_morphology1.34791978
52MP0002210_abnormal_sex_determination1.34416927
53MP0005508_abnormal_skeleton_morphology1.34041111
54MP0010094_abnormal_chromosome_stability1.33095366
55MP0003119_abnormal_digestive_system1.32312558
56MP0005646_abnormal_pituitary_gland1.31939543
57MP0002102_abnormal_ear_morphology1.31765618
58MP0000026_abnormal_inner_ear1.28826195
59MP0010678_abnormal_skin_adnexa1.28606835
60MP0002909_abnormal_adrenal_gland1.27969119
61MP0003698_abnormal_male_reproductive1.27709539
62MP0003786_premature_aging1.27641414
63MP0002734_abnormal_mechanical_nocicepti1.27586461
64MP0010386_abnormal_urinary_bladder1.26486999
65MP0008057_abnormal_DNA_replication1.25957920
66MP0000427_abnormal_hair_cycle1.25931903
67MP0001929_abnormal_gametogenesis1.25694309
68MP0002638_abnormal_pupillary_reflex1.25099481
69MP0008007_abnormal_cellular_replicative1.23850857
70MP0001293_anophthalmia1.22800286
71MP0002282_abnormal_trachea_morphology1.22572376
72MP0001486_abnormal_startle_reflex1.22354493
73MP0006276_abnormal_autonomic_nervous1.22326002
74MP0002116_abnormal_craniofacial_bone1.22226226
75MP0005171_absent_coat_pigmentation1.20901315
76MP0002277_abnormal_respiratory_mucosa1.20140843
77MP0001286_abnormal_eye_development1.19484560
78MP0004270_analgesia1.18405628
79MP0008438_abnormal_cutaneous_collagen1.17456085
80MP0006072_abnormal_retinal_apoptosis1.15906572
81MP0000762_abnormal_tongue_morphology1.15368545
82MP0002272_abnormal_nervous_system1.15252997
83MP0003111_abnormal_nucleus_morphology1.15138396
84MP0005389_reproductive_system_phenotype1.14478930
85MP0003385_abnormal_body_wall1.13482806
86MP0005075_abnormal_melanosome_morpholog1.12166538
87MP0009745_abnormal_behavioral_response1.08589105
88MP0008995_early_reproductive_senescence1.08022408
89MP0004885_abnormal_endolymph1.07651148
90MP0002557_abnormal_social/conspecific_i1.07418271
91MP0000372_irregular_coat_pigmentation1.07014758
92MP0003861_abnormal_nervous_system1.06436501
93MP0005248_abnormal_Harderian_gland1.05498034
94MP0005645_abnormal_hypothalamus_physiol1.04367863
95MP0002752_abnormal_somatic_nervous1.04225212
96MP0001346_abnormal_lacrimal_gland1.04076077
97MP0000613_abnormal_salivary_gland1.03817202
98MP0000647_abnormal_sebaceous_gland1.02994147
99MP0001145_abnormal_male_reproductive1.02828901
100MP0001485_abnormal_pinna_reflex1.02178815
101MP0005551_abnormal_eye_electrophysiolog1.02138637
102MP0003077_abnormal_cell_cycle1.02031001
103MP0005367_renal/urinary_system_phenotyp1.01732395
104MP0000516_abnormal_urinary_system1.01732395
105MP0003806_abnormal_nucleotide_metabolis1.01624082
106MP0002932_abnormal_joint_morphology0.98634467
107MP0002111_abnormal_tail_morphology0.98409618
108MP0003283_abnormal_digestive_organ0.97740895
109MP0004859_abnormal_synaptic_plasticity0.97424104
110MP0001963_abnormal_hearing_physiology0.97044470
111MP0000432_abnormal_head_morphology0.96058138
112MP0000653_abnormal_sex_gland0.95485087
113MP0000749_muscle_degeneration0.95182343
114MP0002177_abnormal_outer_ear0.94838692
115MP0002295_abnormal_pulmonary_circulatio0.94721985
116MP0004381_abnormal_hair_follicle0.93752900
117MP0000955_abnormal_spinal_cord0.92608900
118MP0000579_abnormal_nail_morphology0.91074060
119MP0002184_abnormal_innervation0.90811461
120MP0000358_abnormal_cell_content/0.90699822
121MP0009053_abnormal_anal_canal0.90638394
122MP0000534_abnormal_ureter_morphology0.90617748
123MP0004142_abnormal_muscle_tone0.90255550
124MP0005408_hypopigmentation0.89810956
125MP0005423_abnormal_somatic_nervous0.89543335
126MP0001986_abnormal_taste_sensitivity0.89338834
127MP0002114_abnormal_axial_skeleton0.88880022
128MP0005253_abnormal_eye_physiology0.88674515
129MP0002572_abnormal_emotion/affect_behav0.87689245
130MP0003011_delayed_dark_adaptation0.87275450
131MP0003935_abnormal_craniofacial_develop0.86586409
132MP0005391_vision/eye_phenotype0.86037016
133MP0003950_abnormal_plasma_membrane0.85695252
134MP0004957_abnormal_blastocyst_morpholog0.85620391
135MP0002736_abnormal_nociception_after0.84989270
136MP0002152_abnormal_brain_morphology0.84936988
137MP0002109_abnormal_limb_morphology0.83933017
138MP0004215_abnormal_myocardial_fiber0.81279776
139MP0003635_abnormal_synaptic_transmissio0.80302351
140MP0002928_abnormal_bile_duct0.80058717
141MP0002064_seizures0.79022467
142MP0002063_abnormal_learning/memory/cond0.77424760
143MP0002882_abnormal_neuron_morphology0.77034191
144MP0006036_abnormal_mitochondrial_physio0.76878195
145MP0002234_abnormal_pharynx_morphology0.75462319
146MP0002067_abnormal_sensory_capabilities0.75206074
147MP0000569_abnormal_digit_pigmentation0.74835075
148MP0002876_abnormal_thyroid_physiology0.74308752

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.75422914
2Bronchiectasis (HP:0002110)4.14375872
3Abnormal ciliary motility (HP:0012262)3.89201390
4Abnormal respiratory motile cilium physiology (HP:0012261)3.85117584
5Abnormal respiratory epithelium morphology (HP:0012253)3.40975859
6Abnormal respiratory motile cilium morphology (HP:0005938)3.40975859
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.31124298
8Absent/shortened dynein arms (HP:0200106)3.31124298
9Supernumerary spleens (HP:0009799)3.29484641
10Cystic liver disease (HP:0006706)3.24008909
11Facial cleft (HP:0002006)3.04634094
12Nasal polyposis (HP:0100582)3.02268501
13Pancreatic fibrosis (HP:0100732)3.01765060
14True hermaphroditism (HP:0010459)2.94447803
15Medial flaring of the eyebrow (HP:0010747)2.92609977
16Nephronophthisis (HP:0000090)2.87970928
17Tubulointerstitial nephritis (HP:0001970)2.87799070
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84821555
19Tubular atrophy (HP:0000092)2.76854001
20Bifid tongue (HP:0010297)2.67387874
21Rhinitis (HP:0012384)2.66164825
22Congenital primary aphakia (HP:0007707)2.62573164
23Septo-optic dysplasia (HP:0100842)2.60496169
24Gait imbalance (HP:0002141)2.59425743
25Nephrogenic diabetes insipidus (HP:0009806)2.58948505
26Postaxial foot polydactyly (HP:0001830)2.57656967
27Adrenal hypoplasia (HP:0000835)2.55103147
28Abnormality of the renal medulla (HP:0100957)2.54278219
29Abnormal biliary tract physiology (HP:0012439)2.53050580
30Bile duct proliferation (HP:0001408)2.53050580
31Chromsome breakage (HP:0040012)2.51638214
32Genital tract atresia (HP:0001827)2.43968487
33Embryonal renal neoplasm (HP:0011794)2.43907274
34Abnormality of midbrain morphology (HP:0002418)2.43347286
35Molar tooth sign on MRI (HP:0002419)2.43347286
36Pancreatic cysts (HP:0001737)2.41643801
37Abnormality of the labia minora (HP:0012880)2.41339459
38Vaginal atresia (HP:0000148)2.38423651
39Occipital encephalocele (HP:0002085)2.36561404
40Poor coordination (HP:0002370)2.29954075
41Nephroblastoma (Wilms tumor) (HP:0002667)2.29417222
42Oculomotor apraxia (HP:0000657)2.28346302
43Abnormal lung lobation (HP:0002101)2.25490156
44Median cleft lip (HP:0000161)2.24961558
45Abnormality of the nasal mucosa (HP:0000433)2.24874231
46Recurrent sinusitis (HP:0011108)2.22567108
47Infertility (HP:0000789)2.18901553
48Preaxial hand polydactyly (HP:0001177)2.18334425
49Abnormality of cochlea (HP:0000375)2.15876062
50Abnormal drinking behavior (HP:0030082)2.14475985
51Polydipsia (HP:0001959)2.14475985
52Cerebral hypomyelination (HP:0006808)2.13196838
53Chronic sinusitis (HP:0011109)2.10157468
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.10124563
55Meckel diverticulum (HP:0002245)2.09817757
56Ectopic anus (HP:0004397)2.09350626
57Furrowed tongue (HP:0000221)2.08618699
58Bell-shaped thorax (HP:0001591)2.08346880
59Abnormality of the ileum (HP:0001549)2.07185090
60Abnormality of the phalanges of the hallux (HP:0010057)2.06763488
61Chronic bronchitis (HP:0004469)2.06655914
62Anomalous pulmonary venous return (HP:0010772)2.04790682
63Aplasia/Hypoplasia of the lens (HP:0008063)2.04605849
64Optic nerve hypoplasia (HP:0000609)2.04264523
65Postaxial hand polydactyly (HP:0001162)2.04009593
66Chronic hepatic failure (HP:0100626)2.03630677
67Anencephaly (HP:0002323)2.02092722
68Aplasia/Hypoplasia of the tongue (HP:0010295)2.01691329
69Hypothermia (HP:0002045)2.01259988
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99081358
71Duplicated collecting system (HP:0000081)1.97757966
72Abnormality of dentin (HP:0010299)1.97742826
73Abnormality of the renal collecting system (HP:0004742)1.97607842
74Absent eyebrow (HP:0002223)1.97024914
75Absent radius (HP:0003974)1.95739029
76Bronchitis (HP:0012387)1.95436714
77Abnormal hair whorl (HP:0010721)1.95001772
78Osteomalacia (HP:0002749)1.94353958
79Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94119578
80Acute encephalopathy (HP:0006846)1.92912250
81Aganglionic megacolon (HP:0002251)1.91340528
82Male pseudohermaphroditism (HP:0000037)1.89982062
83Shawl scrotum (HP:0000049)1.88588232
84Congenital hepatic fibrosis (HP:0002612)1.88074492
85Aplasia/Hypoplasia of the patella (HP:0006498)1.84662015
86Patellar aplasia (HP:0006443)1.83927239
87Aplasia involving forearm bones (HP:0009822)1.83293072
88Absent forearm bone (HP:0003953)1.83293072
89Myelomeningocele (HP:0002475)1.83156148
90Abnormality of the lacrimal duct (HP:0011481)1.83097060
91Narrow forehead (HP:0000341)1.82475224
92Type I transferrin isoform profile (HP:0003642)1.81903218
93Abnormality of the pulmonary veins (HP:0011718)1.81058415
94Tubulointerstitial abnormality (HP:0001969)1.80994745
95Aplasia/Hypoplasia of the tibia (HP:0005772)1.80884637
96Intestinal atresia (HP:0011100)1.79559667
97Rib fusion (HP:0000902)1.79083057
98Abnormality of the nasolacrimal system (HP:0000614)1.77590629
99Abnormality of the preputium (HP:0100587)1.77435313
100Aplasia/Hypoplasia of the sternum (HP:0006714)1.75062572
101Anophthalmia (HP:0000528)1.74021244
102Short tibia (HP:0005736)1.73918612
103Ependymoma (HP:0002888)1.73715600
104Bilateral microphthalmos (HP:0007633)1.73651941
105Increased serum pyruvate (HP:0003542)1.72546650
106Gastrointestinal atresia (HP:0002589)1.70321640
107Morphological abnormality of the inner ear (HP:0011390)1.69707803
108Multicystic kidney dysplasia (HP:0000003)1.69582655
109Abnormality of the anterior horn cell (HP:0006802)1.69575038
110Degeneration of anterior horn cells (HP:0002398)1.69575038
111Progressive macrocephaly (HP:0004481)1.69219057
112Tongue fasciculations (HP:0001308)1.68487142
113Sclerocornea (HP:0000647)1.68062869
114Renal hypoplasia (HP:0000089)1.65573361
115Acute necrotizing encephalopathy (HP:0006965)1.65210904
1163-Methylglutaconic aciduria (HP:0003535)1.64852201
117Impulsivity (HP:0100710)1.64847858
118Abnormality of glycolysis (HP:0004366)1.64683810
119Recurrent otitis media (HP:0000403)1.64195839
120Broad foot (HP:0001769)1.63140857
121Renal dysplasia (HP:0000110)1.63073355
122Disproportionate short-trunk short stature (HP:0003521)1.62627142
123Abnormality of the renal cortex (HP:0011035)1.61367082
124Abnormal ventriculo-arterial connection (HP:0011563)1.61280666
125Transposition of the great arteries (HP:0001669)1.61280666
126Abnormal connection of the cardiac segments (HP:0011545)1.61280666
127Prominent nasal bridge (HP:0000426)1.59154049
128Male infertility (HP:0003251)1.58044888
129Type II lissencephaly (HP:0007260)1.57650414
130Abnormal mitochondria in muscle tissue (HP:0008316)1.56771382
131Decreased testicular size (HP:0008734)1.55259072
132Abnormality of the astrocytes (HP:0100707)1.54140964
133Astrocytoma (HP:0009592)1.54140964
134Specific learning disability (HP:0001328)1.52176181
135Retinal dysplasia (HP:0007973)1.48805168
136Mitochondrial inheritance (HP:0001427)1.48616703
137Polyuria (HP:0000103)1.47640096
138Stage 5 chronic kidney disease (HP:0003774)1.45004441
139Hyperventilation (HP:0002883)1.43391409
140Increased CSF lactate (HP:0002490)1.42805405
141Delayed gross motor development (HP:0002194)1.39812124
142Chorioretinal coloboma (HP:0000567)1.39483549
143Holoprosencephaly (HP:0001360)1.38503064
144Atelectasis (HP:0100750)1.37194882
145Optic nerve coloboma (HP:0000588)1.36990515
146Dandy-Walker malformation (HP:0001305)1.36681018
147Chronic otitis media (HP:0000389)1.36529901
148Highly arched eyebrow (HP:0002553)1.35781146
149Left ventricular hypertrophy (HP:0001712)1.34026669
150Aplasia/Hypoplasia of the spleen (HP:0010451)1.33285818

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.71979652
2STK38L2.93152738
3CASK2.92226227
4MAP4K22.90751815
5ERBB32.54211168
6SRPK12.50785074
7BCR2.42338903
8STK162.41919625
9ZAK2.41696903
10PRPF4B2.27490291
11TLK12.12916820
12MKNK21.97693546
13BUB11.97260318
14YES11.92513560
15EPHA41.90638885
16MAP3K121.88652538
17DYRK21.85815208
18WNK31.85631428
19PLK41.82549092
20MAP3K41.81948126
21FRK1.78163828
22BRAF1.75130008
23MST41.65824984
24NEK11.65314067
25MKNK11.64379865
26TRIM281.63181306
27BMPR1B1.59515582
28BMPR21.56369670
29INSRR1.53276074
30TTK1.50192656
31EIF2AK11.44208449
32AURKA1.38315515
33MAPK151.35988350
34PLK31.34117778
35PLK21.32281743
36TSSK61.31736162
37EIF2AK21.31620462
38TAOK21.30138996
39PLK11.28959274
40CSNK1G11.23436527
41PAK31.22497959
42CSNK1G31.22329788
43VRK11.18840068
44EIF2AK31.17878823
45EPHA21.17657792
46CSNK1G21.17317379
47PBK1.14892627
48VRK21.14379049
49MAPK131.14124366
50SIK31.13514687
51WEE11.12823560
52CDK81.12771526
53MAP2K71.12132497
54CSNK1A1L1.11434443
55CCNB11.10294012
56CHEK21.05242569
57STK391.04428678
58PNCK1.00403247
59NTRK31.00262277
60PTK2B0.99644588
61FGFR20.99324409
62ACVR1B0.99033831
63SGK20.97774993
64STK240.97644976
65LATS20.97062506
66EPHA30.95410403
67GRK10.95170102
68SGK4940.94594040
69SGK2230.94594040
70PIK3CG0.94582911
71PASK0.92809360
72CDK70.92181541
73DYRK30.90747258
74ADRBK20.90331637
75NTRK20.88674657
76CDK120.88536456
77BCKDK0.88087951
78IRAK10.85812046
79NEK60.85710774
80IRAK30.83891610
81TNIK0.82557577
82PRKCI0.80605889
83LIMK10.80449138
84BRD40.79898184
85PHKG10.79293893
86PHKG20.79293893
87NUAK10.75860498
88UHMK10.74119380
89MARK10.72245657
90IRAK20.71757092
91MET0.70722890
92CDK30.70596834
93MINK10.67513051
94STK30.64949838
95DDR20.64932022
96OXSR10.63043909
97DYRK1A0.62656301
98ATR0.61286229
99WNK10.61110849
100BRSK10.60387474
101ARAF0.60154428
102WNK40.59376802
103MUSK0.59288676
104TESK10.58376314
105NME10.57328742
106PKN10.56162357
107PIM20.55728071
108PAK60.54735354
109PRKD20.54435105
110PDK40.52039339
111PDK30.52039339
112PINK10.52036694
113ROCK10.51199954
114ATM0.51138527
115CHEK10.50854617
116MAP2K40.50498401
117ERBB40.49340158
118KSR10.46095054
119CSNK2A10.45922705
120AURKB0.45575526
121PAK10.45153070
122EPHB20.44968742
123GRK50.43417556
124LMTK20.42424143
125TGFBR10.42255687
126ADRBK10.41825826
127CDK10.40157095
128RPS6KA40.40051532
129ROCK20.39867915
130CAMK2A0.38169439
131IRAK40.37865499
132BRSK20.37301643
133MAP2K60.36868416
134MAP2K10.36142640
135DYRK1B0.36050500
136FER0.35453290
137MYLK0.34222609
138PRKD30.33977704
139PRKCE0.33911604
140CAMK2G0.32367733
141ILK0.32364863
142PRKCG0.31702184
143CSNK1A10.31501139

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030502.92791277
2Basal transcription factors_Homo sapiens_hsa030222.79153790
3RNA polymerase_Homo sapiens_hsa030202.74921856
4Protein export_Homo sapiens_hsa030602.72215020
5Fanconi anemia pathway_Homo sapiens_hsa034602.69385789
6Homologous recombination_Homo sapiens_hsa034402.66722424
7Steroid biosynthesis_Homo sapiens_hsa001002.42000805
8Non-homologous end-joining_Homo sapiens_hsa034502.41494172
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.39355106
10Mismatch repair_Homo sapiens_hsa034302.38402233
11Propanoate metabolism_Homo sapiens_hsa006402.24790616
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.20153598
13Nucleotide excision repair_Homo sapiens_hsa034202.16648031
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05417616
15Oxidative phosphorylation_Homo sapiens_hsa001902.04438173
16Huntingtons disease_Homo sapiens_hsa050161.97274369
17Base excision repair_Homo sapiens_hsa034101.92212228
18Spliceosome_Homo sapiens_hsa030401.90308340
19RNA transport_Homo sapiens_hsa030131.87593414
20mRNA surveillance pathway_Homo sapiens_hsa030151.87400103
21Ribosome_Homo sapiens_hsa030101.79698008
22Cell cycle_Homo sapiens_hsa041101.74395120
23Hedgehog signaling pathway_Homo sapiens_hsa043401.74079239
24Basal cell carcinoma_Homo sapiens_hsa052171.70812921
25Butanoate metabolism_Homo sapiens_hsa006501.68065137
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67938526
27Arachidonic acid metabolism_Homo sapiens_hsa005901.66718104
28Pyrimidine metabolism_Homo sapiens_hsa002401.54100038
29Parkinsons disease_Homo sapiens_hsa050121.49588254
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47729926
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45237911
32Folate biosynthesis_Homo sapiens_hsa007901.45219820
33RNA degradation_Homo sapiens_hsa030181.44037529
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41250832
35Peroxisome_Homo sapiens_hsa041461.38056814
36beta-Alanine metabolism_Homo sapiens_hsa004101.36325365
37One carbon pool by folate_Homo sapiens_hsa006701.34976993
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34045551
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32773991
40DNA replication_Homo sapiens_hsa030301.29298903
41Hippo signaling pathway_Homo sapiens_hsa043901.28848998
42Circadian rhythm_Homo sapiens_hsa047101.27942910
43Vitamin B6 metabolism_Homo sapiens_hsa007501.27121596
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22084510
45Nicotine addiction_Homo sapiens_hsa050331.21089767
46Phototransduction_Homo sapiens_hsa047441.20197990
47Purine metabolism_Homo sapiens_hsa002301.19589350
48Linoleic acid metabolism_Homo sapiens_hsa005911.13393039
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13241845
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.07657425
51Sulfur metabolism_Homo sapiens_hsa009201.07080465
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07064960
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01200702
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.00281140
55Ether lipid metabolism_Homo sapiens_hsa005651.00035075
56TGF-beta signaling pathway_Homo sapiens_hsa043500.99285246
57Alzheimers disease_Homo sapiens_hsa050100.98236218
58Wnt signaling pathway_Homo sapiens_hsa043100.95061501
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.94494008
60Caffeine metabolism_Homo sapiens_hsa002320.94376482
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93220410
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93122064
63Synaptic vesicle cycle_Homo sapiens_hsa047210.92038037
64Vibrio cholerae infection_Homo sapiens_hsa051100.89439538
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88267262
66Glutathione metabolism_Homo sapiens_hsa004800.87310076
67Fatty acid metabolism_Homo sapiens_hsa012120.86685545
68Selenocompound metabolism_Homo sapiens_hsa004500.86558788
69Insulin secretion_Homo sapiens_hsa049110.85197763
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82083961
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79667522
72Sphingolipid metabolism_Homo sapiens_hsa006000.77955045
73Notch signaling pathway_Homo sapiens_hsa043300.77877261
74Fatty acid degradation_Homo sapiens_hsa000710.77842350
75Axon guidance_Homo sapiens_hsa043600.76629663
76p53 signaling pathway_Homo sapiens_hsa041150.76611746
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74997686
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73869973
79Fatty acid elongation_Homo sapiens_hsa000620.72980881
80Oocyte meiosis_Homo sapiens_hsa041140.72681446
81Cocaine addiction_Homo sapiens_hsa050300.72188082
82Taste transduction_Homo sapiens_hsa047420.70926061
83Fructose and mannose metabolism_Homo sapiens_hsa000510.70687755
84Salivary secretion_Homo sapiens_hsa049700.70402034
85Collecting duct acid secretion_Homo sapiens_hsa049660.69052877
86Arginine and proline metabolism_Homo sapiens_hsa003300.68024878
87Epstein-Barr virus infection_Homo sapiens_hsa051690.67898760
88Tryptophan metabolism_Homo sapiens_hsa003800.67245809
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66176781
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64489268
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63509803
92Carbon metabolism_Homo sapiens_hsa012000.63244602
93Melanoma_Homo sapiens_hsa052180.62598539
94Regulation of autophagy_Homo sapiens_hsa041400.61993244
95Dopaminergic synapse_Homo sapiens_hsa047280.61664487
96Metabolic pathways_Homo sapiens_hsa011000.59123667
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55711519
98Tyrosine metabolism_Homo sapiens_hsa003500.55232293
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54916377
100Serotonergic synapse_Homo sapiens_hsa047260.54623844
101GABAergic synapse_Homo sapiens_hsa047270.52723380
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51876228
103Alcoholism_Homo sapiens_hsa050340.50722419
104Circadian entrainment_Homo sapiens_hsa047130.50169004
105Tight junction_Homo sapiens_hsa045300.48412740
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47578444
107Amphetamine addiction_Homo sapiens_hsa050310.46108258
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45469443
109Prostate cancer_Homo sapiens_hsa052150.45319487
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44626795
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43922134
112Autoimmune thyroid disease_Homo sapiens_hsa053200.43615853
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43104950
114Retinol metabolism_Homo sapiens_hsa008300.41781270
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40189594
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39883312
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38770475
118Pyruvate metabolism_Homo sapiens_hsa006200.38318966
119Chemical carcinogenesis_Homo sapiens_hsa052040.37546632
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37238781
121Pathways in cancer_Homo sapiens_hsa052000.35199994
122Adherens junction_Homo sapiens_hsa045200.31490153
123Cardiac muscle contraction_Homo sapiens_hsa042600.29488399
124Phenylalanine metabolism_Homo sapiens_hsa003600.29154611
125Bladder cancer_Homo sapiens_hsa052190.28697663
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.27525814
127Melanogenesis_Homo sapiens_hsa049160.26219530
128Histidine metabolism_Homo sapiens_hsa003400.25577520
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.25321225
130N-Glycan biosynthesis_Homo sapiens_hsa005100.24659367
131MicroRNAs in cancer_Homo sapiens_hsa052060.22966220
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21968247
133Endometrial cancer_Homo sapiens_hsa052130.21678946
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.20745036

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