IFT52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a conserved proline-rich protein that is a component of the intraflagellar transport-B (IFT-B) core complex. The encoded protein is essential for the integrity of the IFT-B core complex, and for biosynthesis and maintenance of cilia. Mutations in this gene are associated with ciliopathy that affects the skeleton. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.33429072
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.20965407
3Golgi transport vesicle coating (GO:0048200)4.12628649
4COPI coating of Golgi vesicle (GO:0048205)4.12628649
5sequestering of actin monomers (GO:0042989)4.04422959
6chromatin remodeling at centromere (GO:0031055)3.99011657
7DNA damage response, detection of DNA damage (GO:0042769)3.91958313
8CENP-A containing nucleosome assembly (GO:0034080)3.89138263
9DNA ligation (GO:0006266)3.85164984
10maturation of SSU-rRNA (GO:0030490)3.83035149
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.72883349
12ATP synthesis coupled proton transport (GO:0015986)3.72883349
13formation of translation preinitiation complex (GO:0001731)3.64800864
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.60954988
15chaperone-mediated protein transport (GO:0072321)3.60441710
16signal peptide processing (GO:0006465)3.54521271
17cotranslational protein targeting to membrane (GO:0006613)3.53005258
18* intraciliary transport (GO:0042073)3.51826641
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.51009931
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.51009931
21NADH dehydrogenase complex assembly (GO:0010257)3.51009931
22protein targeting to ER (GO:0045047)3.47286605
23DNA deamination (GO:0045006)3.47259180
24oxidative phosphorylation (GO:0006119)3.43664725
25epithelial cilium movement (GO:0003351)3.40821640
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36655791
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36655791
28establishment of viral latency (GO:0019043)3.32627271
29protein neddylation (GO:0045116)3.32341136
30protein localization to endoplasmic reticulum (GO:0070972)3.31433847
31telomere maintenance via semi-conservative replication (GO:0032201)3.30210944
32histone exchange (GO:0043486)3.28591584
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.25454820
34protein complex biogenesis (GO:0070271)3.23245941
35pyrimidine nucleobase catabolic process (GO:0006208)3.21120204
36nucleobase biosynthetic process (GO:0046112)3.20809141
37regulation of cilium movement (GO:0003352)3.19430069
38axonemal dynein complex assembly (GO:0070286)3.19102785
39DNA replication-independent nucleosome assembly (GO:0006336)3.17575754
40DNA replication-independent nucleosome organization (GO:0034724)3.17575754
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.13449645
42viral transcription (GO:0019083)3.13053265
43cullin deneddylation (GO:0010388)3.12229499
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09846985
45translational termination (GO:0006415)3.09061983
46telomere maintenance via recombination (GO:0000722)3.08157403
47translational elongation (GO:0006414)3.08088031
48kinetochore assembly (GO:0051382)3.07144955
49mitochondrial respiratory chain complex assembly (GO:0033108)3.05440085
50regulation of mitotic spindle checkpoint (GO:1903504)3.04820207
51regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04820207
52anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04249167
53DNA strand elongation involved in DNA replication (GO:0006271)3.04071111
54pteridine-containing compound biosynthetic process (GO:0042559)3.03595360
55protein deneddylation (GO:0000338)3.02210292
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01642053
57regulation of mitochondrial translation (GO:0070129)3.00455027
58antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.99505689
59kinetochore organization (GO:0051383)2.98209166
60cilium movement (GO:0003341)2.98094656
61purine nucleobase biosynthetic process (GO:0009113)2.97841858
62nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97252552
63organelle disassembly (GO:1903008)2.93359591
64proteasome assembly (GO:0043248)2.91931994
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91437649
66histone H2A acetylation (GO:0043968)2.89998326
67DNA strand elongation (GO:0022616)2.89563037
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.89365794
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88377036
70DNA double-strand break processing (GO:0000729)2.84434611
71pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.84426788
72DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83816204
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81211629
74intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81211629
75valine metabolic process (GO:0006573)2.79397361
76spliceosomal snRNP assembly (GO:0000387)2.78544878
77IMP biosynthetic process (GO:0006188)2.78534979
78translation (GO:0006412)2.78330414
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.78089272
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.78089272
81signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.78089272
82nucleotide-excision repair, DNA gap filling (GO:0006297)2.77792438
83microtubule depolymerization (GO:0007019)2.76028574
84antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.72203314
85termination of RNA polymerase III transcription (GO:0006386)2.72033540
86transcription elongation from RNA polymerase III promoter (GO:0006385)2.72033540
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71422166
88heart process (GO:0003015)2.69696112
89heart contraction (GO:0060047)2.69696112
90respiratory electron transport chain (GO:0022904)2.69130146
91ribosomal small subunit biogenesis (GO:0042274)2.68911453
92purine-containing compound salvage (GO:0043101)2.68786755
93signal transduction involved in DNA damage checkpoint (GO:0072422)2.68601110
94signal transduction involved in DNA integrity checkpoint (GO:0072401)2.68601110
95daunorubicin metabolic process (GO:0044597)2.68042837
96polyketide metabolic process (GO:0030638)2.68042837
97doxorubicin metabolic process (GO:0044598)2.68042837
98viral mRNA export from host cell nucleus (GO:0046784)2.67255420
99signal transduction involved in cell cycle checkpoint (GO:0072395)2.66790179
100platelet dense granule organization (GO:0060155)2.66632320
101double-strand break repair via nonhomologous end joining (GO:0006303)2.66573458
102non-recombinational repair (GO:0000726)2.66573458
103regulation of helicase activity (GO:0051095)2.66016309
104protein polyglutamylation (GO:0018095)2.65390310
105respiratory chain complex IV assembly (GO:0008535)2.64962478
106mitotic recombination (GO:0006312)2.64462433
107electron transport chain (GO:0022900)2.64159018
108folic acid-containing compound biosynthetic process (GO:0009396)2.63851922
109pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.62747524
110UMP metabolic process (GO:0046049)2.62747524
111pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.62747524
112UMP biosynthetic process (GO:0006222)2.62747524
113antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.62557810
114antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.62557810
115establishment of integrated proviral latency (GO:0075713)2.62534925
116iron-sulfur cluster assembly (GO:0016226)2.62449249
117metallo-sulfur cluster assembly (GO:0031163)2.62449249
118DNA replication initiation (GO:0006270)2.61406076
119ribonucleoprotein complex disassembly (GO:0032988)2.60579650
120aldehyde catabolic process (GO:0046185)2.60317299
121ribosomal large subunit biogenesis (GO:0042273)2.59031168
122positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.58762169
123resolution of meiotic recombination intermediates (GO:0000712)2.57398744
124protein localization to cilium (GO:0061512)2.57145465
125centriole replication (GO:0007099)2.56834618
126pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.56821347
127viral life cycle (GO:0019058)2.56706015
128positive regulation of gamma-delta T cell activation (GO:0046645)2.55519112
129response to interferon-beta (GO:0035456)2.55005250
1307-methylguanosine mRNA capping (GO:0006370)2.54446246
131peptide catabolic process (GO:0043171)2.53716984
132maturation of 5.8S rRNA (GO:0000460)2.53230374
133protein K11-linked ubiquitination (GO:0070979)2.52922309
134regulation of cellular amino acid metabolic process (GO:0006521)2.52405478
135somatic diversification of immune receptors via somatic mutation (GO:0002566)2.51726446
136somatic hypermutation of immunoglobulin genes (GO:0016446)2.51726446
137regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.51512996
138replication fork processing (GO:0031297)2.51498248
139positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.51063293
140nonmotile primary cilium assembly (GO:0035058)2.50145487
141nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.49694421
142translational initiation (GO:0006413)2.49634229
143mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.49389102
144DNA integration (GO:0015074)2.49120794
145spindle checkpoint (GO:0031577)2.48586292
146folic acid metabolic process (GO:0046655)2.48301700
1477-methylguanosine RNA capping (GO:0009452)2.47464489
148RNA capping (GO:0036260)2.47464489
149protein localization to kinetochore (GO:0034501)2.47299729
150pseudouridine synthesis (GO:0001522)2.46643697
151peptidyl-histidine modification (GO:0018202)2.46389772
152positive regulation of ligase activity (GO:0051351)2.45535912
153maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.44507956
154cellular protein complex disassembly (GO:0043624)2.44240070
155rRNA modification (GO:0000154)2.43932076
156synapsis (GO:0007129)2.43549803
157cytochrome complex assembly (GO:0017004)2.42773229
158telomere maintenance via telomere lengthening (GO:0010833)2.42256044
159negative regulation of ligase activity (GO:0051352)2.42014553
160negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.42014553
161cellular component biogenesis (GO:0044085)2.39727373
162negative regulation of phagocytosis (GO:0050765)2.38902009

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.83798184
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.46239474
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45907146
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.45257327
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45100332
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.37802687
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.27993761
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.24568474
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.13282258
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02588763
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.92137785
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79155954
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52073404
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49199125
15* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.46191473
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.46012133
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37232916
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.35917858
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.31359919
20VDR_23849224_ChIP-Seq_CD4+_Human2.28420568
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.26575390
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.24767650
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.24700005
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.21649504
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18165123
26* FOXP3_21729870_ChIP-Seq_TREG_Human2.14991221
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.14567279
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12056118
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11788498
30ZNF274_21170338_ChIP-Seq_K562_Hela2.07886761
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06079153
32IGF1R_20145208_ChIP-Seq_DFB_Human2.05372832
33HOXB4_20404135_ChIP-ChIP_EML_Mouse2.02965352
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.01027994
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.93699369
36GATA1_22025678_ChIP-Seq_K562_Human1.93044367
37FUS_26573619_Chip-Seq_HEK293_Human1.92188594
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91202193
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.90216219
40ELK1_19687146_ChIP-ChIP_HELA_Human1.87113211
41EWS_26573619_Chip-Seq_HEK293_Human1.85167855
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.85041270
43DCP1A_22483619_ChIP-Seq_HELA_Human1.84982088
44XRN2_22483619_ChIP-Seq_HELA_Human1.84103262
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83930481
46* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.83464710
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.82172471
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81475685
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81277032
50VDR_22108803_ChIP-Seq_LS180_Human1.80954369
51* GABP_19822575_ChIP-Seq_HepG2_Human1.79630253
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76215845
53MYC_18940864_ChIP-ChIP_HL60_Human1.74770378
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72811502
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67393397
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66566737
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64626163
58TAF15_26573619_Chip-Seq_HEK293_Human1.64435796
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.58749873
60CIITA_25753668_ChIP-Seq_RAJI_Human1.57324179
61* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57257633
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.56121400
63IRF1_19129219_ChIP-ChIP_H3396_Human1.55905372
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51718712
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50517387
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.49268020
67* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47993037
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47390348
69MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47380575
70SPI1_23547873_ChIP-Seq_NB4_Human1.46585570
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44437201
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42559217
73KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41950642
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.41563460
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41444861
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39634970
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38657160
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37056868
79TTF2_22483619_ChIP-Seq_HELA_Human1.36190753
80TFEB_21752829_ChIP-Seq_HELA_Human1.34882837
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.33481547
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33439488
83SCL_19346495_ChIP-Seq_HPC-7_Human1.32904491
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32150393
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32099843
86P300_19829295_ChIP-Seq_ESCs_Human1.32048482
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31790064
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29031321
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28248894
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25146696
91MYC_22102868_ChIP-Seq_BL_Human1.24996361
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.24995315
93* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23513082
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23165942
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22180661
96NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18857630
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18769549
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16161561
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15542148
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.13868599
101IRF8_21731497_ChIP-ChIP_J774_Mouse1.11234562
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10541406
103CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09084807
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09058388
105RNF2_27304074_Chip-Seq_NSC_Mouse1.07069621
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07056723
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06556587
108CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05270792
109STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03706887
110MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03166032
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02480374
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00391731
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99582131
114E2F1_21310950_ChIP-Seq_MCF-7_Human0.98590335
115KDM5A_27292631_Chip-Seq_BREAST_Human0.98432343
116STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97704669
117ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97544630
118AR_21909140_ChIP-Seq_LNCAP_Human0.96654667
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96650992
120SOX17_20123909_ChIP-Seq_XEN_Mouse0.96587038
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96387951
122PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94862091
123FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94803382
124RXR_22158963_ChIP-Seq_LIVER_Mouse0.94547873
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94198414
126ELK1_22589737_ChIP-Seq_MCF10A_Human0.94156183
127LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94001743
128RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93296255
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92997470
130MYB_26560356_Chip-Seq_TH2_Human0.92538254
131GBX2_23144817_ChIP-Seq_PC3_Human0.91786919
132GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91716980
133RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90844386
134PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90713434
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89766435
136TP53_22573176_ChIP-Seq_HFKS_Human0.89601448
137MYB_26560356_Chip-Seq_TH1_Human0.88277655
138EZH2_22144423_ChIP-Seq_EOC_Human0.88226616
139POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88025346
140BP1_19119308_ChIP-ChIP_Hs578T_Human0.87980898
141NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87474270
142NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87272225
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85447061
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85185340
145CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84624165
146CBX2_27304074_Chip-Seq_ESCs_Mouse0.84284682
147BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84015889
148CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83523743
149SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81166089
150EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78107572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.61716134
2MP0008057_abnormal_DNA_replication3.10133606
3MP0003693_abnormal_embryo_hatching2.87281931
4MP0008789_abnormal_olfactory_epithelium2.80065700
5MP0003122_maternal_imprinting2.74771581
6MP0009697_abnormal_copulation2.69174159
7MP0010030_abnormal_orbit_morphology2.66981813
8MP0002938_white_spotting2.57209494
9MP0001529_abnormal_vocalization2.52466605
10MP0002163_abnormal_gland_morphology2.50420207
11MP0005499_abnormal_olfactory_system2.44536487
12MP0005394_taste/olfaction_phenotype2.44536487
13MP0000566_synostosis2.38733818
14MP0002102_abnormal_ear_morphology2.37557476
15MP0003121_genomic_imprinting2.27372119
16MP0003186_abnormal_redox_activity2.24069629
17MP0005379_endocrine/exocrine_gland_phen2.24028169
18MP0001293_anophthalmia2.23175654
19MP0010094_abnormal_chromosome_stability2.16248370
20MP0002139_abnormal_hepatobiliary_system2.15887385
21MP0001835_abnormal_antigen_presentation2.13508450
22MP0008058_abnormal_DNA_repair2.10717608
23MP0008877_abnormal_DNA_methylation2.10322758
24MP0002396_abnormal_hematopoietic_system2.10172158
25MP0005365_abnormal_bile_salt2.07975757
26MP0008007_abnormal_cellular_replicative2.06101950
27MP0003077_abnormal_cell_cycle2.02934881
28MP0001986_abnormal_taste_sensitivity2.01412371
29MP0001853_heart_inflammation2.00593984
30MP0001984_abnormal_olfaction1.99675093
31MP0004957_abnormal_blastocyst_morpholog1.98040953
32MP0003763_abnormal_thymus_physiology1.97751001
33MP0003136_yellow_coat_color1.91465969
34MP0000685_abnormal_immune_system1.86541946
35MP0006036_abnormal_mitochondrial_physio1.83020927
36MP0005671_abnormal_response_to1.79878947
37MP0009785_altered_susceptibility_to1.78332271
38MP0000372_irregular_coat_pigmentation1.78194796
39MP0004133_heterotaxia1.76902453
40MP0003718_maternal_effect1.74967395
41MP0006072_abnormal_retinal_apoptosis1.72340178
42MP0002233_abnormal_nose_morphology1.71316318
43MP0000778_abnormal_nervous_system1.70091380
44MP0009379_abnormal_foot_pigmentation1.69401965
45MP0005075_abnormal_melanosome_morpholog1.67103262
46MP0003937_abnormal_limbs/digits/tail_de1.66130865
47MP0001764_abnormal_homeostasis1.62181453
48MP0005464_abnormal_platelet_physiology1.60458541
49MP0005084_abnormal_gallbladder_morpholo1.59571995
50MP0005085_abnormal_gallbladder_physiolo1.55006974
51MP0002148_abnormal_hypersensitivity_rea1.53650234
52MP0003183_abnormal_peptide_metabolism1.53624037
53MP0002751_abnormal_autonomic_nervous1.53571931
54MP0000049_abnormal_middle_ear1.53279520
55MP0005220_abnormal_exocrine_pancreas1.52883686
56MP0002234_abnormal_pharynx_morphology1.52412041
57MP0003890_abnormal_embryonic-extraembry1.51425423
58MP0003880_abnormal_central_pattern1.49663211
59MP0003195_calcinosis1.48706328
60MP0002653_abnormal_ependyma_morphology1.46926094
61MP0003724_increased_susceptibility_to1.44799653
62MP0002638_abnormal_pupillary_reflex1.44203614
63MP0002282_abnormal_trachea_morphology1.44161051
64MP0003172_abnormal_lysosome_physiology1.43089417
65MP0000490_abnormal_crypts_of1.42380764
66MP0004808_abnormal_hematopoietic_stem1.41303608
67MP0002138_abnormal_hepatobiliary_system1.40772393
68MP0002877_abnormal_melanocyte_morpholog1.40317459
69MP0001800_abnormal_humoral_immune1.40137958
70MP0005058_abnormal_lysosome_morphology1.39874554
71MP0005025_abnormal_response_to1.39010338
72MP0008875_abnormal_xenobiotic_pharmacok1.37061590
73MP0000689_abnormal_spleen_morphology1.36777747
74MP0002697_abnormal_eye_size1.36058944
75MP0002398_abnormal_bone_marrow1.34351406
76MP0002405_respiratory_system_inflammati1.33809241
77MP0002132_abnormal_respiratory_system1.31885933
78MP0002419_abnormal_innate_immunity1.31133630
79MP0002736_abnormal_nociception_after1.30854017
80MP0001286_abnormal_eye_development1.30823864
81MP0002420_abnormal_adaptive_immunity1.29781084
82MP0002452_abnormal_antigen_presenting1.29356317
83MP0005248_abnormal_Harderian_gland1.28272832
84MP0005360_urolithiasis1.28189921
85MP0005332_abnormal_amino_acid1.27918923
86MP0009643_abnormal_urine_homeostasis1.27491814
87MP0001819_abnormal_immune_cell1.26406311
88MP0003436_decreased_susceptibility_to1.26179918
89MP0005000_abnormal_immune_tolerance1.25734242
90MP0002722_abnormal_immune_system1.25727572
91MP0003119_abnormal_digestive_system1.24670909
92MP0002822_catalepsy1.23801170
93MP0002723_abnormal_immune_serum1.23769257
94MP0002933_joint_inflammation1.23524305
95MP0005253_abnormal_eye_physiology1.23061019
96MP0001790_abnormal_immune_system1.22355559
97MP0005387_immune_system_phenotype1.22355559
98MP0005171_absent_coat_pigmentation1.21264190
99MP0006276_abnormal_autonomic_nervous1.20724697
100MP0006035_abnormal_mitochondrial_morpho1.19703127
101MP0009333_abnormal_splenocyte_physiolog1.18834033
102MP0010155_abnormal_intestine_physiology1.17968735
103MP0003943_abnormal_hepatobiliary_system1.17681157
104MP0001845_abnormal_inflammatory_respons1.17518653
105MP0000716_abnormal_immune_system1.17418264
106MP0000631_abnormal_neuroendocrine_gland1.16069778
107MP0001299_abnormal_eye_distance/1.15272481
108MP0002429_abnormal_blood_cell1.14981410
109MP0000647_abnormal_sebaceous_gland1.14892162
110MP0000013_abnormal_adipose_tissue1.14620597
111MP0003787_abnormal_imprinting1.13609690
112MP0003938_abnormal_ear_development1.13120080
113MP0003567_abnormal_fetal_cardiomyocyte1.11552885
114MP0003111_abnormal_nucleus_morphology1.10464617
115MP0003755_abnormal_palate_morphology1.09560645
116MP0005391_vision/eye_phenotype1.08636891
117MP0000343_altered_response_to1.08393457
118MP0002019_abnormal_tumor_incidence1.07029922
119MP0005319_abnormal_enzyme/_coenzyme1.06405026
120MP0000678_abnormal_parathyroid_gland1.05133059
121MP0003011_delayed_dark_adaptation1.04675087
122MP0003861_abnormal_nervous_system1.03327407
123MP0003786_premature_aging1.03278623
124MP0002693_abnormal_pancreas_physiology1.03090907
125MP0005551_abnormal_eye_electrophysiolog1.02100002
126MP0001324_abnormal_eye_pigmentation1.01737240
127MP0008469_abnormal_protein_level1.01160905
128MP0002210_abnormal_sex_determination0.99141655
129MP0002084_abnormal_developmental_patter0.99083254
130MP0005408_hypopigmentation0.98854511
131MP0006292_abnormal_olfactory_placode0.98558716
132MP0000703_abnormal_thymus_morphology0.98461730
133MP0000598_abnormal_liver_morphology0.98236180
134MP0001346_abnormal_lacrimal_gland0.97447278
135MP0004147_increased_porphyrin_level0.96989093
136MP0005310_abnormal_salivary_gland0.96370328
137MP0002166_altered_tumor_susceptibility0.95823208
138MP0003866_abnormal_defecation0.95208059
139MP0006082_CNS_inflammation0.94963158
140MP0008995_early_reproductive_senescence0.94731737
141MP0005670_abnormal_white_adipose0.94242933
142MP0003191_abnormal_cellular_cholesterol0.93823866
143MP0001929_abnormal_gametogenesis0.93724082
144MP0001545_abnormal_hematopoietic_system0.92686133
145MP0005397_hematopoietic_system_phenotyp0.92686133
146MP0003123_paternal_imprinting0.92273997
147MP0001666_abnormal_nutrient_absorption0.92047712
148MP0002928_abnormal_bile_duct0.91751587
149MP0002085_abnormal_embryonic_tissue0.91344802
150MP0000465_gastrointestinal_hemorrhage0.90769359
151MP0003315_abnormal_perineum_morphology0.87963207
152MP0005195_abnormal_posterior_eye0.87661814
153MP0000313_abnormal_cell_death0.87487884
154MP0000653_abnormal_sex_gland0.87340763
155MP0002092_abnormal_eye_morphology0.87016275
156MP0000609_abnormal_liver_physiology0.86995655
157MP0005584_abnormal_enzyme/coenzyme_acti0.86550302
158MP0006054_spinal_hemorrhage0.86141323
159MP0002752_abnormal_somatic_nervous0.86124572
160MP0005636_abnormal_mineral_homeostasis0.85161239
161MP0008932_abnormal_embryonic_tissue0.84886700
162MP0000358_abnormal_cell_content/0.82406413
163MP0005187_abnormal_penis_morphology0.82237069
164MP0004142_abnormal_muscle_tone0.82019920
165MP0003942_abnormal_urinary_system0.81159778
166MP0005266_abnormal_metabolism0.80527282
167MP0009765_abnormal_xenobiotic_induced0.79617761
168MP0009763_increased_sensitivity_to0.79297402
169MP0001145_abnormal_male_reproductive0.79247068
170MP0002184_abnormal_innervation0.78608685
171MP0002090_abnormal_vision0.77643075
172MP0000026_abnormal_inner_ear0.77567276
173MP0002160_abnormal_reproductive_system0.76485276
174MP0002111_abnormal_tail_morphology0.76463187
175MP0000537_abnormal_urethra_morphology0.74929196
176MP0003698_abnormal_male_reproductive0.74254586
177MP0003385_abnormal_body_wall0.73899376
178MP0001485_abnormal_pinna_reflex0.73457519
179MP0003941_abnormal_skin_development0.71278776
180MP0009250_abnormal_appendicular_skeleto0.71186182
181MP0001188_hyperpigmentation0.70533340
182MP0002557_abnormal_social/conspecific_i0.70308395
183MP0001697_abnormal_embryo_size0.70246954

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.75922969
2Generalized aminoaciduria (HP:0002909)3.52937885
3Decreased activity of mitochondrial respiratory chain (HP:0008972)3.51615200
4Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.51615200
5Hepatic necrosis (HP:0002605)3.47961509
6Aplastic anemia (HP:0001915)3.46964481
7Abnormality of the labia minora (HP:0012880)3.35310425
8Hepatocellular necrosis (HP:0001404)3.14872998
9Thrombocytosis (HP:0001894)3.13399008
10Abnormal respiratory motile cilium physiology (HP:0012261)3.08026956
11Medial flaring of the eyebrow (HP:0010747)3.07198437
1211 pairs of ribs (HP:0000878)3.03876558
13Pancreatic cysts (HP:0001737)3.01252725
14Hypoglycemic coma (HP:0001325)2.99335694
15Type I transferrin isoform profile (HP:0003642)2.99187042
16Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.96647232
17Abnormal respiratory motile cilium morphology (HP:0005938)2.96624357
18Abnormal respiratory epithelium morphology (HP:0012253)2.96624357
19Rhinitis (HP:0012384)2.95238631
20Abnormality of midbrain morphology (HP:0002418)2.90300486
21Molar tooth sign on MRI (HP:0002419)2.90300486
22Increased CSF lactate (HP:0002490)2.87253717
23Abnormal mitochondria in muscle tissue (HP:0008316)2.87161651
24Abnormal ciliary motility (HP:0012262)2.86845924
25Acute encephalopathy (HP:0006846)2.81756741
26Reduced antithrombin III activity (HP:0001976)2.81171108
27Congenital primary aphakia (HP:0007707)2.81132836
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.80344071
29Abnormal protein N-linked glycosylation (HP:0012347)2.80344071
30Abnormal protein glycosylation (HP:0012346)2.80344071
31Abnormal glycosylation (HP:0012345)2.80344071
32Mitochondrial inheritance (HP:0001427)2.79529851
33Gait imbalance (HP:0002141)2.75207387
34Abnormality of fatty-acid metabolism (HP:0004359)2.74713135
35Abnormality of aromatic amino acid family metabolism (HP:0004338)2.74534093
36Nephronophthisis (HP:0000090)2.71869196
37Acute necrotizing encephalopathy (HP:0006965)2.68537306
38Abnormality of the intrinsic pathway (HP:0010989)2.68488776
39Colon cancer (HP:0003003)2.67487221
40Eczematoid dermatitis (HP:0000976)2.63657414
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.61166523
42Nephrogenic diabetes insipidus (HP:0009806)2.60122751
43Occipital encephalocele (HP:0002085)2.58284541
44Abnormal lung lobation (HP:0002101)2.57188317
45Increased serum lactate (HP:0002151)2.55116178
46Genital tract atresia (HP:0001827)2.53583995
47Vaginal atresia (HP:0000148)2.51647525
48Increased intramyocellular lipid droplets (HP:0012240)2.49427340
49IgM deficiency (HP:0002850)2.48013910
50Abnormality of methionine metabolism (HP:0010901)2.47364011
51Vacuolated lymphocytes (HP:0001922)2.43484235
52Supernumerary spleens (HP:0009799)2.42188550
53Hypothermia (HP:0002045)2.42135353
54Lactic acidosis (HP:0003128)2.41955958
55Sclerocornea (HP:0000647)2.39634141
56Increased muscle lipid content (HP:0009058)2.38905235
57Septo-optic dysplasia (HP:0100842)2.37966290
58Anencephaly (HP:0002323)2.34959647
59Dicarboxylic aciduria (HP:0003215)2.33712115
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.33712115
61Postaxial foot polydactyly (HP:0001830)2.33105129
62Renal cortical cysts (HP:0000803)2.31517346
63Anophthalmia (HP:0000528)2.30160681
64Hypoplastic pelvis (HP:0008839)2.29701809
65Chronic hepatic failure (HP:0100626)2.25779912
66Postaxial hand polydactyly (HP:0001162)2.24184904
67Late onset (HP:0003584)2.22708411
68Lipid accumulation in hepatocytes (HP:0006561)2.22685839
69Pancreatic fibrosis (HP:0100732)2.22014899
70Preaxial hand polydactyly (HP:0001177)2.21528264
71Bifid tongue (HP:0010297)2.21105857
72Abnormality of the anterior horn cell (HP:0006802)2.20106508
73Degeneration of anterior horn cells (HP:0002398)2.20106508
74Limb hypertonia (HP:0002509)2.19039485
75Exercise intolerance (HP:0003546)2.18929429
76Oral leukoplakia (HP:0002745)2.17134703
77Methylmalonic aciduria (HP:0012120)2.16969136
78Dynein arm defect of respiratory motile cilia (HP:0012255)2.14591747
79Absent/shortened dynein arms (HP:0200106)2.14591747
80Microvesicular hepatic steatosis (HP:0001414)2.12166111
81Abnormality of urine glucose concentration (HP:0011016)2.11673204
82Glycosuria (HP:0003076)2.11673204
83Stenosis of the external auditory canal (HP:0000402)2.09706762
84Hyperinsulinemic hypoglycemia (HP:0000825)2.08793346
85Abnormality of cells of the erythroid lineage (HP:0012130)2.08748844
86Volvulus (HP:0002580)2.08731328
87Reticulocytopenia (HP:0001896)2.07763007
88Increased hepatocellular lipid droplets (HP:0006565)2.07332750
89True hermaphroditism (HP:0010459)2.03749860
90Renal hypoplasia (HP:0000089)2.03352906
91Recurrent bacterial skin infections (HP:0005406)2.03236378
92Megaloblastic anemia (HP:0001889)2.02986148
93Abnormality of the renal medulla (HP:0100957)2.02899394
94Abnormal number of erythroid precursors (HP:0012131)2.01946293
95Pancytopenia (HP:0001876)2.01316166
96Chronic bronchitis (HP:0004469)2.01106505
97Bronchitis (HP:0012387)1.99613668
98Lethargy (HP:0001254)1.99482833
99Recurrent bronchitis (HP:0002837)1.98618444
100Absent septum pellucidum (HP:0001331)1.97857065
101Meckel diverticulum (HP:0002245)1.97151265
102Broad foot (HP:0001769)1.97150964
103Exertional dyspnea (HP:0002875)1.96423916
104Spontaneous hematomas (HP:0007420)1.95849683
105Hypobetalipoproteinemia (HP:0003563)1.95757156
106Cerebral edema (HP:0002181)1.95755749
107Short tibia (HP:0005736)1.95745807
108Hyperglycinuria (HP:0003108)1.95016774
109Progressive macrocephaly (HP:0004481)1.93877076
1103-Methylglutaconic aciduria (HP:0003535)1.93186289
111Methylmalonic acidemia (HP:0002912)1.93072084
112Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92994906
113Increased serum pyruvate (HP:0003542)1.92845834
114Tongue fasciculations (HP:0001308)1.92321689
115Ragged-red muscle fibers (HP:0003200)1.91644407
116Abnormality of the ileum (HP:0001549)1.91405878
117Optic nerve coloboma (HP:0000588)1.90948920
118Decreased testicular size (HP:0008734)1.90637684
119Cystic liver disease (HP:0006706)1.90079654
120Recurrent abscess formation (HP:0002722)1.90067656
121Respiratory difficulties (HP:0002880)1.89172629
122Hyperglycinemia (HP:0002154)1.88223853
123Delayed CNS myelination (HP:0002188)1.87158911
124Abnormality of the nasal mucosa (HP:0000433)1.86756464
125Tubulointerstitial nephritis (HP:0001970)1.86677431
126Nasal polyposis (HP:0100582)1.86341125
127Hypoplasia of the thymus (HP:0000778)1.86245346
128Granulocytopenia (HP:0001913)1.86049645
129Median cleft lip (HP:0000161)1.84719976
130Abnormal hemoglobin (HP:0011902)1.84599580
131Renal Fanconi syndrome (HP:0001994)1.84410709
132Elevated erythrocyte sedimentation rate (HP:0003565)1.84285741
133Cortical dysplasia (HP:0002539)1.83995887
134Optic disc pallor (HP:0000543)1.83462597
135Male pseudohermaphroditism (HP:0000037)1.83396579
136Abnormality of monocarboxylic acid metabolism (HP:0010996)1.83064790
137Pancreatic islet-cell hyperplasia (HP:0004510)1.81369899
138Triphalangeal thumb (HP:0001199)1.81280054
139Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80769240
140Abnormality of vitamin B metabolism (HP:0004340)1.80369600
141Ketoacidosis (HP:0001993)1.80243620
142Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80230800
143Hypoglycemic seizures (HP:0002173)1.80174019
144Abnormality of serine family amino acid metabolism (HP:0010894)1.79859155
145Abnormality of glycine metabolism (HP:0010895)1.79859155
146Recurrent gram-negative bacterial infections (HP:0005420)1.79487625
147Aplasia/Hypoplasia of the uvula (HP:0010293)1.77731444
148Homocystinuria (HP:0002156)1.77359639
149Abnormality of homocysteine metabolism (HP:0010919)1.77359639
150Intestinal atresia (HP:0011100)1.77108358
151Beaking of vertebral bodies (HP:0004568)1.75933657
152Metabolic acidosis (HP:0001942)1.75546509
153Neutropenia (HP:0001875)1.75005313
154Macrocytic anemia (HP:0001972)1.74846711
155Hyperammonemia (HP:0001987)1.74768367
156Dandy-Walker malformation (HP:0001305)1.74274827
157Abnormality of glycolysis (HP:0004366)1.74190758
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.72931477
159Chorioretinal coloboma (HP:0000567)1.71705133
160Retinal dysplasia (HP:0007973)1.70560337
161Atrophy/Degeneration involving motor neurons (HP:0007373)1.70392696
162Abnormal biliary tract physiology (HP:0012439)1.70137297
163Bile duct proliferation (HP:0001408)1.70137297
164Polyphagia (HP:0002591)1.68668390
165Narrow forehead (HP:0000341)1.68351222
166Oculomotor apraxia (HP:0000657)1.68282694
167Poor coordination (HP:0002370)1.67844456

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.27171774
2FLT33.24574196
3TRIM283.16482663
4VRK23.10557925
5WNK33.02265181
6PASK2.65476237
7ACVR1B2.53661164
8MAP4K12.46910666
9BCR2.40360589
10NEK12.38039664
11TGFBR12.37044744
12CDK82.33528382
13TXK2.32685514
14WEE12.31239672
15BRSK22.18528502
16EIF2AK32.10197589
17ZAP702.06622285
18MKNK22.01877759
19NUAK11.97862707
20BCKDK1.97733324
21CDK191.96236090
22PLK31.94277645
23DYRK21.87686907
24TEC1.83105312
25SRPK11.82509170
26MAP4K21.80206540
27MAP3K41.72423771
28BUB11.72011132
29MAP2K71.69625409
30TTK1.63089862
31EIF2AK11.62112682
32PIM21.58098620
33KIT1.57021694
34TESK11.56834228
35DYRK31.55593998
36PDK21.54496918
37BTK1.51692293
38VRK11.51405778
39KDR1.48781464
40MAP3K121.46867272
41MAPK151.45472535
42RPS6KB21.40797464
43CSNK1G21.40192951
44TNIK1.39785182
45BMPR1B1.38241956
46CDC71.36475987
47CSNK1G31.34292397
48NEK91.32339061
49TAOK31.30714943
50TYK21.29756618
51CDK71.29184863
52IKBKB1.27723564
53ERN11.25407780
54PNCK1.25170679
55NEK21.25122861
56STK38L1.24305304
57MYLK1.23635912
58CASK1.23133195
59IKBKE1.22214299
60MAP2K31.18617131
61BRSK11.18323812
62ATR1.18261416
63CSNK1G11.18110875
64CSNK1A1L1.11822294
65MAP2K61.11276756
66IRAK31.08628384
67MARK11.08074739
68PLK21.06653794
69STK241.06251076
70MINK11.04675795
71RPS6KA41.04497927
72STK101.04462035
73IRAK41.03031821
74TSSK61.01569295
75PRKG21.01504225
76PDK31.00310014
77PDK41.00310014
78ITK0.98657585
79EPHB20.97215971
80PIM10.92962356
81TGFBR20.92077905
82CCNB10.89882057
83MAP3K30.89437036
84MELK0.87859773
85PBK0.87548719
86PINK10.85578455
87JAK30.83577330
88SYK0.82702972
89ARAF0.80694692
90TAF10.79104618
91EPHA40.78754111
92NME20.78429465
93LYN0.75926438
94MATK0.75796657
95MAP3K110.74125723
96STK390.73742828
97ADRBK20.72788159
98MKNK10.72755900
99AURKB0.72400564
100MST40.71879409
101CHEK20.70749166
102AURKA0.70339594
103BLK0.70127549
104MAP2K40.69506508
105PIK3CG0.68995641
106MAPK130.68712544
107PLK10.68466169
108PAK30.67926197
109TBK10.67199669
110DAPK10.65216469
111MAP3K50.64232133
112PRKCG0.62416375
113LCK0.61991459
114TLK10.61657934
115GRK60.61047001
116OXSR10.61004862
117PLK40.60092834
118MAP3K140.60082914
119ERBB40.59092034
120STK30.58568198
121MAPKAPK30.58548542
122NEK60.57218141
123ATM0.56751696
124EIF2AK20.56577928
125RPS6KB10.55765820
126CSNK2A10.55631437
127CDK40.55621923
128BRD40.55254435
129LIMK10.52172176
130YES10.52003229
131MAPK110.51705800
132IRAK10.51678050
133INSRR0.51098529
134NME10.50741423
135GRK10.50258903
136AKT30.49933583
137CDK140.49784322
138ERBB30.49625138
139RPS6KA60.49607877
140ZAK0.47600770
141LRRK20.47200773
142CDK180.47143592
143PRKCE0.46909913
144CSF1R0.46700042
145CSNK2A20.46491676
146BRAF0.45578670
147TRPM70.45436894
148FGFR10.45357610
149RPS6KL10.45288783
150RPS6KC10.45288783
151CHUK0.45266894
152DYRK1A0.44938409
153SIK30.43998476
154FGFR20.43644330
155CDK11A0.41370254
156TIE10.41250819
157CHEK10.38758058
158RPS6KA50.38565039
159CDK150.37775496
160DYRK1B0.37693958
161UHMK10.32345431
162WNK40.31628172
163CSNK1E0.31033681
164KSR10.29963025

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.40806725
2Mismatch repair_Homo sapiens_hsa034303.40197368
3DNA replication_Homo sapiens_hsa030303.26217342
4Proteasome_Homo sapiens_hsa030503.15389307
5Ribosome_Homo sapiens_hsa030103.07404245
6Base excision repair_Homo sapiens_hsa034102.61659776
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.17768715
8RNA polymerase_Homo sapiens_hsa030202.14003844
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.02943589
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99120951
11Homologous recombination_Homo sapiens_hsa034401.96076870
12Pyrimidine metabolism_Homo sapiens_hsa002401.85108319
13Nucleotide excision repair_Homo sapiens_hsa034201.84195723
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.80759230
15Spliceosome_Homo sapiens_hsa030401.80315835
16Steroid biosynthesis_Homo sapiens_hsa001001.72921874
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68560931
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.66959819
19Oxidative phosphorylation_Homo sapiens_hsa001901.56093297
20One carbon pool by folate_Homo sapiens_hsa006701.55281222
21RNA degradation_Homo sapiens_hsa030181.54125160
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51727211
23Parkinsons disease_Homo sapiens_hsa050121.48155052
24Non-homologous end-joining_Homo sapiens_hsa034501.47540961
25Galactose metabolism_Homo sapiens_hsa000521.46639365
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44775832
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40771525
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40276469
29RNA transport_Homo sapiens_hsa030131.39251947
30Folate biosynthesis_Homo sapiens_hsa007901.37240707
31Propanoate metabolism_Homo sapiens_hsa006401.35331327
32Other glycan degradation_Homo sapiens_hsa005111.34947003
33Pyruvate metabolism_Homo sapiens_hsa006201.34160492
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27746807
35Peroxisome_Homo sapiens_hsa041461.26771089
36Carbon metabolism_Homo sapiens_hsa012001.25695701
37N-Glycan biosynthesis_Homo sapiens_hsa005101.23351957
38Tryptophan metabolism_Homo sapiens_hsa003801.18474978
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17968522
40Huntingtons disease_Homo sapiens_hsa050161.15769777
41Glutathione metabolism_Homo sapiens_hsa004801.15408387
42Fructose and mannose metabolism_Homo sapiens_hsa000511.15092559
43Phototransduction_Homo sapiens_hsa047441.14791484
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14407438
45Selenocompound metabolism_Homo sapiens_hsa004501.12260939
46Cell cycle_Homo sapiens_hsa041101.11955990
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10376129
48Basal transcription factors_Homo sapiens_hsa030221.09862088
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09750843
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08292523
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07591247
52Pentose phosphate pathway_Homo sapiens_hsa000301.07151842
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07004731
54Antigen processing and presentation_Homo sapiens_hsa046121.05111539
55Fatty acid degradation_Homo sapiens_hsa000711.04871804
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04332108
57Primary immunodeficiency_Homo sapiens_hsa053401.04184959
58Basal cell carcinoma_Homo sapiens_hsa052171.01034516
59Biosynthesis of amino acids_Homo sapiens_hsa012301.00139887
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.99920495
61Cardiac muscle contraction_Homo sapiens_hsa042600.99736068
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99516495
63Purine metabolism_Homo sapiens_hsa002300.99194104
64Legionellosis_Homo sapiens_hsa051340.98270313
65Fanconi anemia pathway_Homo sapiens_hsa034600.97997045
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96245027
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94267424
68Hedgehog signaling pathway_Homo sapiens_hsa043400.93580839
69Chemical carcinogenesis_Homo sapiens_hsa052040.93445542
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92927808
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92336782
72Oocyte meiosis_Homo sapiens_hsa041140.86075509
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85737540
74Starch and sucrose metabolism_Homo sapiens_hsa005000.82896459
75Alzheimers disease_Homo sapiens_hsa050100.79588143
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.78894532
77Collecting duct acid secretion_Homo sapiens_hsa049660.76214823
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71506637
79Metabolic pathways_Homo sapiens_hsa011000.67319117
80Nicotine addiction_Homo sapiens_hsa050330.64720116
81Histidine metabolism_Homo sapiens_hsa003400.63463139
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63352685
83p53 signaling pathway_Homo sapiens_hsa041150.62387881
84Arachidonic acid metabolism_Homo sapiens_hsa005900.61886315
85Herpes simplex infection_Homo sapiens_hsa051680.61022039
86Fatty acid elongation_Homo sapiens_hsa000620.60000680
87Sulfur metabolism_Homo sapiens_hsa009200.58323529
88Hippo signaling pathway_Homo sapiens_hsa043900.57754981
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57040267
90mRNA surveillance pathway_Homo sapiens_hsa030150.56679209
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56403842
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.54798553
93Regulation of autophagy_Homo sapiens_hsa041400.52300736
94Vibrio cholerae infection_Homo sapiens_hsa051100.51488290
95Epstein-Barr virus infection_Homo sapiens_hsa051690.50030890
96Measles_Homo sapiens_hsa051620.48418415
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47098024
98Complement and coagulation cascades_Homo sapiens_hsa046100.46497158
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45027812
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43048813
101Fatty acid metabolism_Homo sapiens_hsa012120.42734565
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41519170
103Nitrogen metabolism_Homo sapiens_hsa009100.41185494
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41132426
105Hematopoietic cell lineage_Homo sapiens_hsa046400.40410190
106TGF-beta signaling pathway_Homo sapiens_hsa043500.40380341
107Renin-angiotensin system_Homo sapiens_hsa046140.40054028
108Wnt signaling pathway_Homo sapiens_hsa043100.39317482
109Tyrosine metabolism_Homo sapiens_hsa003500.37874389
110Olfactory transduction_Homo sapiens_hsa047400.37713959
111Lysosome_Homo sapiens_hsa041420.36792523
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36052724
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.35038473
114Taste transduction_Homo sapiens_hsa047420.34447190
115Shigellosis_Homo sapiens_hsa051310.33344140
116Arginine and proline metabolism_Homo sapiens_hsa003300.32820182
117Caffeine metabolism_Homo sapiens_hsa002320.32345332
118Phenylalanine metabolism_Homo sapiens_hsa003600.32214973
119beta-Alanine metabolism_Homo sapiens_hsa004100.31840762
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31727536
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29933736
122Butanoate metabolism_Homo sapiens_hsa006500.28914783
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28791161
124Alcoholism_Homo sapiens_hsa050340.26372075
125Axon guidance_Homo sapiens_hsa043600.22330072
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21657085
127GABAergic synapse_Homo sapiens_hsa047270.20709257
128Retinol metabolism_Homo sapiens_hsa008300.20117420
129Sulfur relay system_Homo sapiens_hsa041220.19831970

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