IFT57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)6.80045442
2axoneme assembly (GO:0035082)6.41778440
3Golgi transport vesicle coating (GO:0048200)5.80678853
4COPI coating of Golgi vesicle (GO:0048205)5.80678853
5protein maturation by protein folding (GO:0022417)5.09377480
6* left/right pattern formation (GO:0060972)4.89875777
7* cilium organization (GO:0044782)4.79626896
8* cilium assembly (GO:0042384)4.66670560
9left/right axis specification (GO:0070986)4.56301414
10cilium morphogenesis (GO:0060271)4.36624272
11detection of calcium ion (GO:0005513)4.01148714
12centriole replication (GO:0007099)3.98806155
13ventricular system development (GO:0021591)3.92934058
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.89744769
15centriole assembly (GO:0098534)3.87256795
16synaptic vesicle exocytosis (GO:0016079)3.85687293
17nonmotile primary cilium assembly (GO:0035058)3.79033475
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.71487183
19regulation of short-term neuronal synaptic plasticity (GO:0048172)3.68957868
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.67815402
21regulation of microtubule-based movement (GO:0060632)3.66947548
22microtubule bundle formation (GO:0001578)3.65617266
23regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.63229377
24* cellular component assembly involved in morphogenesis (GO:0010927)3.58365921
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55961000
26synaptic vesicle maturation (GO:0016188)3.55683930
27maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.51940968
28locomotory exploration behavior (GO:0035641)3.50354441
29regulation of synaptic vesicle exocytosis (GO:2000300)3.47577195
30peptide hormone processing (GO:0016486)3.42989003
31nucleoside diphosphate phosphorylation (GO:0006165)3.40362633
32regulation of type B pancreatic cell apoptotic process (GO:2000674)3.40107905
33aldehyde catabolic process (GO:0046185)3.39168232
34insulin secretion (GO:0030073)3.34455463
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.33535035
36positive regulation of vesicle fusion (GO:0031340)3.32706832
37cullin deneddylation (GO:0010388)3.32330745
38protein neddylation (GO:0045116)3.31933879
39ribosomal small subunit assembly (GO:0000028)3.30867832
40glutamate secretion (GO:0014047)3.30700192
41GTP biosynthetic process (GO:0006183)3.28105422
42regulation of vesicle fusion (GO:0031338)3.25257360
43innervation (GO:0060384)3.24362788
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.24336316
45cotranslational protein targeting to membrane (GO:0006613)3.24315149
46viral transcription (GO:0019083)3.22416661
47ATP synthesis coupled proton transport (GO:0015986)3.22175214
48energy coupled proton transport, down electrochemical gradient (GO:0015985)3.22175214
49neuronal action potential propagation (GO:0019227)3.20347271
50protein targeting to ER (GO:0045047)3.18506698
51ER overload response (GO:0006983)3.16995661
52primary alcohol catabolic process (GO:0034310)3.16740965
53translational termination (GO:0006415)3.16510995
54signal peptide processing (GO:0006465)3.15026181
55proteasome assembly (GO:0043248)3.13456428
56protein retention in ER lumen (GO:0006621)3.09867473
57regulation of synaptic vesicle transport (GO:1902803)3.07536119
58determination of left/right symmetry (GO:0007368)3.06438513
59* microtubule-based movement (GO:0007018)3.06359246
60pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.06320534
61establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06273431
62microtubule depolymerization (GO:0007019)3.04782412
63cilium or flagellum-dependent cell motility (GO:0001539)3.03467535
64sequestering of actin monomers (GO:0042989)3.02896544
65chaperone-mediated protein transport (GO:0072321)3.02211761
66protein localization to endoplasmic reticulum (GO:0070972)3.00883377
67ionotropic glutamate receptor signaling pathway (GO:0035235)2.97543475
68* cell projection assembly (GO:0030031)2.96877518
69determination of bilateral symmetry (GO:0009855)2.95353287
70inner ear receptor cell development (GO:0060119)2.95218328
71specification of symmetry (GO:0009799)2.92848535
72regulation of amyloid precursor protein catabolic process (GO:1902991)2.92534722
73activation of protein kinase A activity (GO:0034199)2.91388706
74chromatin remodeling at centromere (GO:0031055)2.90339778
75* smoothened signaling pathway (GO:0007224)2.90193067
76protein complex biogenesis (GO:0070271)2.89048995
77positive regulation of synaptic transmission, GABAergic (GO:0032230)2.86861184
78regulation of long-term neuronal synaptic plasticity (GO:0048169)2.86827379
79electron transport chain (GO:0022900)2.86105709
80cerebellar Purkinje cell layer development (GO:0021680)2.85671627
81DNA damage response, detection of DNA damage (GO:0042769)2.85422950
82protein localization to cilium (GO:0061512)2.84663126
83sperm motility (GO:0030317)2.84209350
84respiratory electron transport chain (GO:0022904)2.82721751
85CENP-A containing nucleosome assembly (GO:0034080)2.82604268
86protein deneddylation (GO:0000338)2.82354294
87exploration behavior (GO:0035640)2.81665833
88negative regulation of T cell differentiation in thymus (GO:0033085)2.79176938
89synaptic vesicle docking involved in exocytosis (GO:0016081)2.78751531
90protein polyglutamylation (GO:0018095)2.76841175
91regulation of calcium ion-dependent exocytosis (GO:0017158)2.76781969
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76572475
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76572475
94regulation of insulin secretion (GO:0050796)2.74913968
95glutamate receptor signaling pathway (GO:0007215)2.73832089
96neuron cell-cell adhesion (GO:0007158)2.73371131
97establishment of planar polarity (GO:0001736)2.73187926
98establishment of tissue polarity (GO:0007164)2.73187926
99calcium ion-dependent exocytosis (GO:0017156)2.72816194
100regulation of neuronal synaptic plasticity (GO:0048168)2.72695936
101sequestering of metal ion (GO:0051238)2.72204740
102lateral sprouting from an epithelium (GO:0060601)2.71788334
103type B pancreatic cell development (GO:0003323)2.71193066
104regulation of beta-amyloid formation (GO:1902003)2.70334176
105lateral ventricle development (GO:0021670)2.69723041
106long-term synaptic potentiation (GO:0060291)2.68999646
107mitochondrial respiratory chain complex I assembly (GO:0032981)2.68846802
108NADH dehydrogenase complex assembly (GO:0010257)2.68846802
109mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.68846802
110UTP biosynthetic process (GO:0006228)2.68489666
111mitochondrial respiratory chain complex assembly (GO:0033108)2.67894524
112terpenoid biosynthetic process (GO:0016114)2.67869507
113translational elongation (GO:0006414)2.67844950
114base-excision repair, AP site formation (GO:0006285)2.67687410
115retinal rod cell development (GO:0046548)2.67662021
116negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.67654935
117presynaptic membrane assembly (GO:0097105)2.67619485
118positive regulation of insulin secretion (GO:0032024)2.67007201
119inositol phosphate catabolic process (GO:0071545)2.66975328
120regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.66664142
121ribosomal large subunit biogenesis (GO:0042273)2.65862543
122* intraciliary transport (GO:0042073)2.64233157
123synaptic transmission, glutamatergic (GO:0035249)2.63835799
124microtubule polymerization or depolymerization (GO:0031109)2.63246830
125photoreceptor cell maintenance (GO:0045494)2.61915989
126inositol phosphate dephosphorylation (GO:0046855)2.60920521
127phosphorylated carbohydrate dephosphorylation (GO:0046838)2.60920521
128pyrimidine nucleotide catabolic process (GO:0006244)2.60387454
129maturation of SSU-rRNA (GO:0030490)2.60012981
130negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.59211675
131postsynaptic membrane organization (GO:0001941)2.58719564
132UTP metabolic process (GO:0046051)2.58241211
133peptide hormone secretion (GO:0030072)2.58048049
134positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.56521892
135protein localization to synapse (GO:0035418)2.55361505
136vesicle transport along microtubule (GO:0047496)2.55172943
137chemosensory behavior (GO:0007635)2.55133866
138regulation of cilium movement (GO:0003352)2.54839395
139cellular protein complex disassembly (GO:0043624)2.54688221
140protein localization to Golgi apparatus (GO:0034067)2.53523763
141vesicle coating (GO:0006901)2.53458054
142regulation of actin nucleation (GO:0051125)2.53324209
143activation of adenylate cyclase activity (GO:0007190)2.52891329
144regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.52559763
145pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.51586844
146endocrine pancreas development (GO:0031018)2.51500470
147cellular potassium ion homeostasis (GO:0030007)2.50729601
148histone exchange (GO:0043486)2.50488719
149neuron-neuron synaptic transmission (GO:0007270)2.49660528
150neurotransmitter secretion (GO:0007269)2.49617667
151intra-Golgi vesicle-mediated transport (GO:0006891)2.49405077
152regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.47286717
153G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.47270397
154suckling behavior (GO:0001967)2.46943465
155regulation of glutamate receptor signaling pathway (GO:1900449)2.46606682
156peptide secretion (GO:0002790)2.45535178
157regulation of peptide hormone secretion (GO:0090276)2.45176179
158epithelial cilium movement (GO:0003351)2.44413248
159viral life cycle (GO:0019058)2.44103159
160guanosine-containing compound biosynthetic process (GO:1901070)2.43933096
161regulation of peptide secretion (GO:0002791)2.43790268
162translational initiation (GO:0006413)2.43433362
163vitamin transmembrane transport (GO:0035461)2.42213211
164cellular response to glucagon stimulus (GO:0071377)2.41592776
165cellular response to vitamin D (GO:0071305)2.41581080
166cerebellum development (GO:0021549)2.41015644
167cilium movement (GO:0003341)2.40516095
168synaptic vesicle transport (GO:0048489)2.40297972
169establishment of synaptic vesicle localization (GO:0097480)2.40297972
170CTP biosynthetic process (GO:0006241)2.40212975
171CTP metabolic process (GO:0046036)2.40212975
172nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.39996150
173negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.39612911
174epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.39274035
175nucleoside diphosphate catabolic process (GO:0009134)2.39210946
176negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.38332279
177organelle disassembly (GO:1903008)2.38280368
178regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.37760881
179regulation of exocytosis (GO:0017157)2.37689423
180retinal cone cell development (GO:0046549)2.37671375
181positive regulation of neurotransmitter secretion (GO:0001956)2.37175189
182melanosome transport (GO:0032402)2.36975468
183serotonin metabolic process (GO:0042428)2.36782764
184regulation of synaptic plasticity (GO:0048167)2.35376310
185purine nucleoside triphosphate biosynthetic process (GO:0009145)2.34106683
186translation (GO:0006412)2.33955421
187histone H2A acetylation (GO:0043968)2.33482946
188proline transport (GO:0015824)2.33415255
189negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.33293858
190negative regulation of calcium ion transmembrane transport (GO:1903170)2.33293858
191neuron fate determination (GO:0048664)2.33216458
192lung epithelium development (GO:0060428)2.32542464
193axonemal dynein complex assembly (GO:0070286)11.2222806

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.45340069
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.21740621
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.90293497
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.62336283
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.33089727
6GBX2_23144817_ChIP-Seq_PC3_Human3.25413054
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07808376
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.70503006
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58283878
10REST_21632747_ChIP-Seq_MESCs_Mouse2.50195754
11EWS_26573619_Chip-Seq_HEK293_Human2.42051724
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40923424
13ELK1_19687146_ChIP-ChIP_HELA_Human2.31539914
14IGF1R_20145208_ChIP-Seq_DFB_Human2.31078675
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29078977
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20624725
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19884265
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.08939087
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07650648
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06797036
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06373056
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05422294
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05351356
24JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04067381
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97698602
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.97657697
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97330427
28ZNF274_21170338_ChIP-Seq_K562_Hela1.94895231
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94234396
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92663352
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.91356919
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86737099
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85562904
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84256597
35* VDR_23849224_ChIP-Seq_CD4+_Human1.80954091
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78845077
37* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77613842
38SMAD4_21799915_ChIP-Seq_A2780_Human1.77515541
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.75112943
40* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69427582
41* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.68848745
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66528054
43DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.66042679
44MYC_18940864_ChIP-ChIP_HL60_Human1.64243201
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62988100
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.61486688
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61334327
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56856019
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.56343409
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.52731231
51DROSHA_22980978_ChIP-Seq_HELA_Human1.52523636
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51341897
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.50726928
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49774365
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49199614
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.48258828
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44492555
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43171579
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43171579
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42227147
61* FUS_26573619_Chip-Seq_HEK293_Human1.41206529
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.40661186
63P300_19829295_ChIP-Seq_ESCs_Human1.40281269
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35512491
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34237297
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31158251
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28723942
68RNF2_27304074_Chip-Seq_NSC_Mouse1.27707586
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.27109180
70DCP1A_22483619_ChIP-Seq_HELA_Human1.27038947
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27032479
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26182688
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25902256
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25865343
75GABP_19822575_ChIP-Seq_HepG2_Human1.25846078
76FOXP3_21729870_ChIP-Seq_TREG_Human1.25388433
77STAT3_23295773_ChIP-Seq_U87_Human1.22843495
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22515924
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22340898
80* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22068690
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.21783636
82TTF2_22483619_ChIP-Seq_HELA_Human1.21531155
83TAF15_26573619_Chip-Seq_HEK293_Human1.21289858
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20758849
85IRF1_19129219_ChIP-ChIP_H3396_Human1.17044360
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16413395
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15714389
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15109893
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14512176
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14328476
91* AR_20517297_ChIP-Seq_VCAP_Human1.14036751
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13957541
93TCF4_22108803_ChIP-Seq_LS180_Human1.12280423
94TCF4_23295773_ChIP-Seq_U87_Human1.12192161
95P53_22387025_ChIP-Seq_ESCs_Mouse1.11737807
96* AR_25329375_ChIP-Seq_VCAP_Human1.11302145
97* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09213433
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08231722
99FOXA1_25329375_ChIP-Seq_VCAP_Human1.07985889
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07985889
101TP53_18474530_ChIP-ChIP_U2OS_Human1.07916263
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07841409
103* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07606725
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.05930896
105E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05133825
106VDR_22108803_ChIP-Seq_LS180_Human1.04387032
107BCAT_22108803_ChIP-Seq_LS180_Human1.04282396
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03504336
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01300865
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.00930633
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00377542
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.00372304
113FLI1_27457419_Chip-Seq_LIVER_Mouse0.99616233
114PIAS1_25552417_ChIP-Seq_VCAP_Human0.98726465
115XRN2_22483619_ChIP-Seq_HELA_Human0.98507353
116* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98442203
117ER_23166858_ChIP-Seq_MCF-7_Human0.98415698
118YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98305585
119CMYC_18555785_Chip-Seq_ESCs_Mouse0.98160736
120SMAD3_21741376_ChIP-Seq_ESCs_Human0.97973804
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97632088
122TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97223312
123RUNX2_22187159_ChIP-Seq_PCA_Human0.97146253
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96481995
125* SOX2_19829295_ChIP-Seq_ESCs_Human0.95623657
126* NANOG_19829295_ChIP-Seq_ESCs_Human0.95623657
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94541550
128PHF8_20622853_ChIP-Seq_HELA_Human0.93949995
129PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93719509
130FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93561599
131AR_19668381_ChIP-Seq_PC3_Human0.92945013
132NANOG_16153702_ChIP-ChIP_HESCs_Human0.92932417
133SOX2_18555785_Chip-Seq_ESCs_Mouse0.92619946
134KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92617518
135BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92599080
136ELK1_22589737_ChIP-Seq_MCF10A_Human0.92243663
137TP53_22573176_ChIP-Seq_HFKS_Human0.91439385
138CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91332735
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89599672
140NMYC_18555785_Chip-Seq_ESCs_Mouse0.89485993
141* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89045341
142PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88450002
143E2F1_18555785_Chip-Seq_ESCs_Mouse0.87309131
144STAT3_18555785_Chip-Seq_ESCs_Mouse0.86614256
145OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85899886
146CBX2_27304074_Chip-Seq_ESCs_Mouse0.85892124
147* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85386401
148TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84796809
149MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84157677
150JUN_21703547_ChIP-Seq_K562_Human0.84148318
151KDM2B_26808549_Chip-Seq_REH_Human0.84060338
152RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83403872
153SMAD_19615063_ChIP-ChIP_OVARY_Human0.82139181
154FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81495837
155RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.81062476
156P300_18555785_Chip-Seq_ESCs_Mouse0.80705162
157REST_19997604_ChIP-ChIP_NEURONS_Mouse0.80474882
158CBP_20019798_ChIP-Seq_JUKART_Human0.80432887
159IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80432887

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.52887825
2MP0004859_abnormal_synaptic_plasticity3.91475761
3MP0003183_abnormal_peptide_metabolism3.22072759
4MP0002909_abnormal_adrenal_gland3.09262520
5MP0004270_analgesia2.92177020
6MP0003880_abnormal_central_pattern2.84828179
7MP0003635_abnormal_synaptic_transmissio2.83475717
8MP0010030_abnormal_orbit_morphology2.80582411
9MP0010386_abnormal_urinary_bladder2.75694683
10MP0000013_abnormal_adipose_tissue2.75308628
11MP0002877_abnormal_melanocyte_morpholog2.71259296
12MP0005379_endocrine/exocrine_gland_phen2.53741083
13MP0009780_abnormal_chondrocyte_physiolo2.50578322
14MP0005645_abnormal_hypothalamus_physiol2.50546031
15MP0009379_abnormal_foot_pigmentation2.47871898
16MP0001293_anophthalmia2.45488458
17MP0004133_heterotaxia2.38120723
18MP0003283_abnormal_digestive_organ2.31652312
19MP0008875_abnormal_xenobiotic_pharmacok2.29148294
20MP0002282_abnormal_trachea_morphology2.26793844
21MP0002837_dystrophic_cardiac_calcinosis2.23886602
22MP0006292_abnormal_olfactory_placode2.23620414
23MP0002063_abnormal_learning/memory/cond2.23370181
24MP0001984_abnormal_olfaction2.22752000
25MP0005646_abnormal_pituitary_gland2.21822971
26MP0000566_synostosis2.20041829
27MP0002693_abnormal_pancreas_physiology2.09192551
28MP0009745_abnormal_behavioral_response2.04474963
29MP0002938_white_spotting2.02262849
30MP0001944_abnormal_pancreas_morphology2.01894244
31MP0002734_abnormal_mechanical_nocicepti2.01447144
32MP0003172_abnormal_lysosome_physiology2.01383019
33MP0002572_abnormal_emotion/affect_behav1.96391728
34MP0003136_yellow_coat_color1.94383647
35MP0002233_abnormal_nose_morphology1.93892196
36MP0002064_seizures1.93722118
37MP0004043_abnormal_pH_regulation1.90804235
38MP0002132_abnormal_respiratory_system1.90708411
39MP0000678_abnormal_parathyroid_gland1.89566277
40MP0008058_abnormal_DNA_repair1.84640438
41MP0002102_abnormal_ear_morphology1.82897200
42MP0001986_abnormal_taste_sensitivity1.81781837
43MP0003122_maternal_imprinting1.79173369
44MP0001502_abnormal_circadian_rhythm1.74932440
45MP0003937_abnormal_limbs/digits/tail_de1.74007878
46MP0001968_abnormal_touch/_nociception1.73436584
47MP0002733_abnormal_thermal_nociception1.72123721
48MP0008995_early_reproductive_senescence1.70893160
49MP0002272_abnormal_nervous_system1.70880632
50MP0002160_abnormal_reproductive_system1.67321954
51MP0002735_abnormal_chemical_nociception1.65831783
52MP0003329_amyloid_beta_deposits1.63762104
53MP0004858_abnormal_nervous_system1.61812675
54MP0008877_abnormal_DNA_methylation1.61329467
55MP0000049_abnormal_middle_ear1.60260207
56MP0002876_abnormal_thyroid_physiology1.60102969
57MP0002638_abnormal_pupillary_reflex1.59928838
58MP0006072_abnormal_retinal_apoptosis1.59873608
59MP0001970_abnormal_pain_threshold1.59740267
60MP0000383_abnormal_hair_follicle1.59406616
61MP0009046_muscle_twitch1.54914097
62MP0005248_abnormal_Harderian_gland1.48969953
63MP0002163_abnormal_gland_morphology1.48678103
64MP0002736_abnormal_nociception_after1.46304621
65MP0002277_abnormal_respiratory_mucosa1.42756167
66MP0001501_abnormal_sleep_pattern1.42240189
67MP0005410_abnormal_fertilization1.41081498
68MP0002557_abnormal_social/conspecific_i1.39470726
69MP0005084_abnormal_gallbladder_morpholo1.31420707
70MP0006276_abnormal_autonomic_nervous1.30672929
71MP0003186_abnormal_redox_activity1.30442294
72MP0002184_abnormal_innervation1.30172832
73MP0005551_abnormal_eye_electrophysiolog1.28640402
74MP0001348_abnormal_lacrimal_gland1.26999208
75MP0002067_abnormal_sensory_capabilities1.25413615
76MP0000631_abnormal_neuroendocrine_gland1.25347424
77MP0005623_abnormal_meninges_morphology1.24638921
78MP0005391_vision/eye_phenotype1.23455020
79MP0003786_premature_aging1.23225482
80MP0001929_abnormal_gametogenesis1.22831731
81MP0003718_maternal_effect1.22664636
82MP0010678_abnormal_skin_adnexa1.22330897
83MP0000681_abnormal_thyroid_gland1.22306737
84MP0001485_abnormal_pinna_reflex1.22012615
85MP0001286_abnormal_eye_development1.21511135
86MP0001486_abnormal_startle_reflex1.19898249
87MP0003121_genomic_imprinting1.18306368
88MP0005423_abnormal_somatic_nervous1.17495061
89MP0000026_abnormal_inner_ear1.17237165
90MP0001529_abnormal_vocalization1.14421319
91MP0008569_lethality_at_weaning1.14255563
92MP0000003_abnormal_adipose_tissue1.13150565
93MP0003879_abnormal_hair_cell1.12869619
94MP0002210_abnormal_sex_determination1.12239740
95MP0003755_abnormal_palate_morphology1.10755409
96MP0001440_abnormal_grooming_behavior1.09879524
97MP0001765_abnormal_ion_homeostasis1.09690437
98MP0004811_abnormal_neuron_physiology1.09661467
99MP0005310_abnormal_salivary_gland1.09465259
100MP0010368_abnormal_lymphatic_system1.09285606
101MP0001346_abnormal_lacrimal_gland1.08574817
102MP0003633_abnormal_nervous_system1.07284444
103MP0003698_abnormal_male_reproductive1.06933553
104MP0001145_abnormal_male_reproductive1.04770462
105MP0006054_spinal_hemorrhage1.04697167
106MP0001879_abnormal_lymphatic_vessel1.04141628
107MP0003890_abnormal_embryonic-extraembry1.03341533
108MP0000653_abnormal_sex_gland1.03037201
109MP0000537_abnormal_urethra_morphology1.02612995
110* MP0000955_abnormal_spinal_cord1.01681123
111MP0005195_abnormal_posterior_eye1.00961765
112MP0001188_hyperpigmentation1.00307782
113MP0003119_abnormal_digestive_system0.97731702
114MP0000778_abnormal_nervous_system0.96861673
115MP0004924_abnormal_behavior0.96244187
116MP0005386_behavior/neurological_phenoty0.96244187
117MP0003938_abnormal_ear_development0.95558351
118MP0005220_abnormal_exocrine_pancreas0.95075243
119* MP0002084_abnormal_developmental_patter0.94916252
120MP0001324_abnormal_eye_pigmentation0.94507632
121MP0005389_reproductive_system_phenotype0.94106850
122MP0002882_abnormal_neuron_morphology0.93623706
123MP0002234_abnormal_pharynx_morphology0.92492036
124MP0002092_abnormal_eye_morphology0.92469997
125MP0003942_abnormal_urinary_system0.91798221
126MP0005394_taste/olfaction_phenotype0.91644334
127MP0005499_abnormal_olfactory_system0.91644334
128MP0008932_abnormal_embryonic_tissue0.91186308
129MP0003787_abnormal_imprinting0.90866021
130MP0002752_abnormal_somatic_nervous0.90808908
131MP0005535_abnormal_body_temperature0.90041560
132MP0002066_abnormal_motor_capabilities/c0.89076091
133MP0002295_abnormal_pulmonary_circulatio0.88257979
134MP0002896_abnormal_bone_mineralization0.87275783
135* MP0003861_abnormal_nervous_system0.87166700
136MP0002078_abnormal_glucose_homeostasis0.85286752
137MP0009053_abnormal_anal_canal0.83658648
138MP0002697_abnormal_eye_size0.83177952
139MP0008789_abnormal_olfactory_epithelium0.82547498
140MP0008961_abnormal_basal_metabolism0.81665431
141MP0001905_abnormal_dopamine_level0.81524972
142MP0002249_abnormal_larynx_morphology0.80958617
143MP0003634_abnormal_glial_cell0.80504885
144MP0001963_abnormal_hearing_physiology0.80157362
145MP0004510_myositis0.79742910
146* MP0002116_abnormal_craniofacial_bone0.79520998
147MP0004957_abnormal_blastocyst_morpholog0.79114769
148MP0002090_abnormal_vision0.78936753
149MP0005253_abnormal_eye_physiology0.77785535
150* MP0002085_abnormal_embryonic_tissue0.77232085
151MP0006036_abnormal_mitochondrial_physio0.77019019
152MP0005395_other_phenotype0.76764235
153MP0003011_delayed_dark_adaptation0.76497679
154MP0002932_abnormal_joint_morphology0.75607451
155MP0005058_abnormal_lysosome_morphology0.75245461
156MP0005367_renal/urinary_system_phenotyp0.74547385
157MP0000516_abnormal_urinary_system0.74547385
158MP0009250_abnormal_appendicular_skeleto0.74372198
159MP0005409_darkened_coat_color0.72063317
160MP0004145_abnormal_muscle_electrophysio0.67154380
161MP0002928_abnormal_bile_duct0.65688273
162MP0003953_abnormal_hormone_level0.65411272
163MP0002069_abnormal_eating/drinking_beha0.65037043
164MP0004885_abnormal_endolymph0.64787594
165* MP0001299_abnormal_eye_distance/0.64770603
166MP0004142_abnormal_muscle_tone0.64267384
167MP0003631_nervous_system_phenotype0.64251191
168* MP0002152_abnormal_brain_morphology0.64100361
169MP0002751_abnormal_autonomic_nervous0.63152339
170MP0000604_amyloidosis0.59214781
171MP0005187_abnormal_penis_morphology0.58969587
172MP0004233_abnormal_muscle_weight0.56641576
173MP0002229_neurodegeneration0.56104250

Predicted human phenotypes

RankGene SetZ-score
1Bronchiectasis (HP:0002110)4.86233306
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.19112086
3Papilledema (HP:0001085)3.87333209
4Occipital encephalocele (HP:0002085)3.70148679
5Focal motor seizures (HP:0011153)3.63069747
6Visual hallucinations (HP:0002367)3.60461027
7Nasal polyposis (HP:0100582)3.31782883
8Postaxial foot polydactyly (HP:0001830)3.25848719
9Tubulointerstitial nephritis (HP:0001970)3.20241496
10Epileptic encephalopathy (HP:0200134)3.18972437
11Chronic hepatic failure (HP:0100626)3.17616594
12Abnormality of the renal medulla (HP:0100957)3.16785282
13Medial flaring of the eyebrow (HP:0010747)3.09838922
14Dysostosis multiplex (HP:0000943)3.08421766
15Aplasia/Hypoplasia of the tongue (HP:0010295)3.03540014
16Hypothermia (HP:0002045)3.02839529
17Pheochromocytoma (HP:0002666)2.95885657
18Gait imbalance (HP:0002141)2.94722023
19Infertility (HP:0000789)2.94026283
20Mucopolysacchariduria (HP:0008155)2.91312403
21Urinary glycosaminoglycan excretion (HP:0003541)2.91312403
22Hyperinsulinemic hypoglycemia (HP:0000825)2.91181162
23Chronic sinusitis (HP:0011109)2.90215777
24Abnormality of calcium-phosphate metabolism (HP:0100530)2.89430460
25Congenital primary aphakia (HP:0007707)2.86805859
26Absent/shortened dynein arms (HP:0200106)2.83972049
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.83972049
28Anencephaly (HP:0002323)2.78641177
29Neuroendocrine neoplasm (HP:0100634)2.78378694
30Agitation (HP:0000713)2.74257256
31Nephrogenic diabetes insipidus (HP:0009806)2.74254004
32Sclerocornea (HP:0000647)2.72174871
33Bronchitis (HP:0012387)2.69470501
34Atonic seizures (HP:0010819)2.67403283
35Focal seizures (HP:0007359)2.67318874
36Recurrent sinusitis (HP:0011108)2.65458321
37Congenital hepatic fibrosis (HP:0002612)2.65427496
38Epileptiform EEG discharges (HP:0011182)2.59454163
39Abnormality of polysaccharide metabolism (HP:0011012)2.57219604
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.57219604
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.57219604
42Postaxial hand polydactyly (HP:0001162)2.56828330
43Abnormality of the nasal mucosa (HP:0000433)2.54964739
44Retinal dysplasia (HP:0007973)2.50824674
45EEG with generalized epileptiform discharges (HP:0011198)2.50802858
46Median cleft lip (HP:0000161)2.48701596
47Pancreatic fibrosis (HP:0100732)2.47617096
48Preaxial hand polydactyly (HP:0001177)2.44966296
49Male pseudohermaphroditism (HP:0000037)2.44715209
50Acute necrotizing encephalopathy (HP:0006965)2.42310871
51Rhinitis (HP:0012384)2.39038205
52Hypsarrhythmia (HP:0002521)2.38182685
53True hermaphroditism (HP:0010459)2.38087316
54Abnormal respiratory motile cilium morphology (HP:0005938)2.36829603
55Abnormal respiratory epithelium morphology (HP:0012253)2.36829603
56Molar tooth sign on MRI (HP:0002419)2.36725758
57Abnormality of midbrain morphology (HP:0002418)2.36725758
58Abnormal respiratory motile cilium physiology (HP:0012261)2.36449269
59Abnormal ciliary motility (HP:0012262)2.33220703
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.31893751
61Symptomatic seizures (HP:0011145)2.30248395
62Absence seizures (HP:0002121)2.29509836
63Hypoglycemic seizures (HP:0002173)2.27197361
64Chronic bronchitis (HP:0004469)2.26636041
65Truncal ataxia (HP:0002078)2.25305304
66Menstrual irregularities (HP:0000858)2.24892364
67Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.23212278
68Oculomotor apraxia (HP:0000657)2.20203127
69Mitochondrial inheritance (HP:0001427)2.15363185
70Recurrent otitis media (HP:0000403)2.14411590
71Neoplasm of the peripheral nervous system (HP:0100007)2.14312147
72Hypercortisolism (HP:0001578)2.14256494
73Decreased circulating renin level (HP:0003351)2.13170320
74Tubular atrophy (HP:0000092)2.12826118
75Abnormal biliary tract physiology (HP:0012439)2.12818080
76Bile duct proliferation (HP:0001408)2.12818080
77Dysautonomia (HP:0002459)2.10639447
78Poor coordination (HP:0002370)2.09419084
79Hemiparesis (HP:0001269)2.09002956
80Abnormal mitochondria in muscle tissue (HP:0008316)2.07965373
81Acute encephalopathy (HP:0006846)2.07888262
82Large for gestational age (HP:0001520)2.07326041
83Male infertility (HP:0003251)2.07067289
84Supranuclear gaze palsy (HP:0000605)2.06284934
85Neurofibrillary tangles (HP:0002185)2.06212601
86Dialeptic seizures (HP:0011146)2.05618988
87Hyperparathyroidism (HP:0000843)2.03555556
88Depression (HP:0000716)2.03195675
89Limb dystonia (HP:0002451)2.01506710
90Progressive macrocephaly (HP:0004481)1.99525890
91Type II lissencephaly (HP:0007260)1.99253983
92Hepatocellular necrosis (HP:0001404)1.97332120
93Cerebral inclusion bodies (HP:0100314)1.96828282
94Megalencephaly (HP:0001355)1.96174279
95Furrowed tongue (HP:0000221)1.96096943
96Tubulointerstitial abnormality (HP:0001969)1.95658416
97Hyperphosphatemia (HP:0002905)1.95391287
98Hyperactive renin-angiotensin system (HP:0000841)1.95266433
99Macroorchidism (HP:0000053)1.94119289
100Genital tract atresia (HP:0001827)1.94087929
101Impaired smooth pursuit (HP:0007772)1.93962242
102Aplasia/Hypoplasia of the spleen (HP:0010451)1.92116056
103Supernumerary spleens (HP:0009799)1.90957819
104Abnormality of macular pigmentation (HP:0008002)1.89668235
105Vaginal atresia (HP:0000148)1.89229640
106Anxiety (HP:0000739)1.88749421
107Bifid tongue (HP:0010297)1.87412596
108Spinal canal stenosis (HP:0003416)1.86894127
109Myokymia (HP:0002411)1.85806566
110Increased hepatocellular lipid droplets (HP:0006565)1.85795217
111Increased CSF lactate (HP:0002490)1.85025718
112Flared iliac wings (HP:0002869)1.83539994
113Disproportionate short-trunk short stature (HP:0003521)1.83310165
114Asplenia (HP:0001746)1.83093428
115Anophthalmia (HP:0000528)1.82690038
116Abnormality of the renal cortex (HP:0011035)1.82647537
117Cystic liver disease (HP:0006706)1.81821750
118Progressive neurologic deterioration (HP:0002344)1.81319507
119Febrile seizures (HP:0002373)1.80901197
120Generalized tonic-clonic seizures (HP:0002069)1.79181442
121Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77745969
122Abnormal protein N-linked glycosylation (HP:0012347)1.77745969
123Abnormal protein glycosylation (HP:0012346)1.77745969
124Abnormal glycosylation (HP:0012345)1.77745969
125Aplasia/Hypoplasia of the lens (HP:0008063)1.77534210
126Hepatic necrosis (HP:0002605)1.76530844
127Broad foot (HP:0001769)1.76425206
128Narrow forehead (HP:0000341)1.74174089
129Pancreatic cysts (HP:0001737)1.74094038
130Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.73622314
131Nuclear cataract (HP:0100018)1.73355883
132Progressive cerebellar ataxia (HP:0002073)1.73069421
133Deep palmar crease (HP:0006191)1.72496872
134Abnormality of the frontal sinuses (HP:0002687)1.71498300
135Insulin-resistant diabetes mellitus (HP:0000831)1.70144207
136Cortical visual impairment (HP:0100704)1.69673535
137Ankyloglossia (HP:0010296)1.69338633
138Absent speech (HP:0001344)1.68813169
139Widely spaced teeth (HP:0000687)1.68735786
140Facial cleft (HP:0002006)1.68391210
141Amblyopia (HP:0000646)1.67459346
142Nephronophthisis (HP:0000090)1.67233743
143Stage 5 chronic kidney disease (HP:0003774)1.66682554
144Orthostatic hypotension (HP:0001278)1.66526245
145Poor eye contact (HP:0000817)1.66323904
146Abnormal rod and cone electroretinograms (HP:0008323)1.66232125
147Broad face (HP:0000283)1.66051007
148Decreased testicular size (HP:0008734)1.65403861
149Aganglionic megacolon (HP:0002251)1.65202285
150Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.65178895
151Spondylolisthesis (HP:0003302)1.64575695
152Progressive sensorineural hearing impairment (HP:0000408)1.63687961
153Late onset (HP:0003584)1.63535422
154Nephropathy (HP:0000112)1.62729842
1553-Methylglutaconic aciduria (HP:0003535)1.62542854
156Congenital, generalized hypertrichosis (HP:0004540)1.61730788
157Lipid accumulation in hepatocytes (HP:0006561)1.60873730
158Renal Fanconi syndrome (HP:0001994)1.60871682
159Stenosis of the external auditory canal (HP:0000402)1.59496534
160Central scotoma (HP:0000603)1.58030754
161Multicystic kidney dysplasia (HP:0000003)1.57890370
162Optic nerve coloboma (HP:0000588)1.56717196
163Short tibia (HP:0005736)1.55742239
164Chorioretinal coloboma (HP:0000567)1.55604165
165Specific learning disability (HP:0001328)1.53113218
166Abnormality of renal resorption (HP:0011038)1.52188068
167Reticulocytopenia (HP:0001896)1.52008338
168Absent rod-and cone-mediated responses on ERG (HP:0007688)1.50107855
169Cerebral edema (HP:0002181)1.48857965
170Holoprosencephaly (HP:0001360)1.48440425
171Prominent nasal bridge (HP:0000426)1.46806573
172Septo-optic dysplasia (HP:0100842)1.44230044
173Aplasia/Hypoplasia of the tibia (HP:0005772)1.42970315
174Hyperglycinemia (HP:0002154)1.42803483
175Renal dysplasia (HP:0000110)1.39904347
176Degeneration of anterior horn cells (HP:0002398)1.38405056
177Abnormality of the anterior horn cell (HP:0006802)1.38405056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.04410663
2MST43.98937596
3RIPK43.22774981
4PRKD33.06914886
5INSRR2.75418228
6MAPK152.71071812
7TNIK2.68225786
8FRK2.64173167
9NTRK12.58038986
10CAMKK22.57635723
11BMPR1B2.54352270
12MAP4K22.45067022
13BMPR22.35798671
14VRK22.28849900
15PASK2.19837574
16ARAF2.12515718
17SCYL22.06371398
18EPHA42.05744875
19TRIM282.05487491
20MINK12.00734774
21MAP2K71.97148108
22EPHA21.82648374
23MAP3K91.82381440
24SRPK11.79386317
25MAP3K121.77561833
26HIPK21.77133990
27GRK11.75569476
28WNK41.72662276
29WNK31.70568719
30PLK41.64509546
31MAP3K21.64431828
32KSR11.61017056
33UHMK11.58815729
34MAP3K41.57717893
35VRK11.56173325
36SIK31.56109121
37FES1.53477755
38IRAK11.52193114
39KSR21.50199435
40CDC71.46248801
41BCKDK1.44903756
42MKNK11.44374815
43CASK1.43290168
44NUAK11.40414199
45CAMKK11.39757415
46BUB11.38531651
47PLK31.38103314
48WEE11.37258015
49BRSK21.34327612
50TESK11.33778313
51PLK21.30574590
52PBK1.30101031
53EPHB21.27332991
54DAPK11.27203936
55TIE11.27084836
56CDK81.25862179
57LIMK11.25271342
58ERBB31.22751636
59CDK51.21277861
60BRAF1.17516208
61FLT31.15695271
62MAPK131.10794424
63PLK11.10584215
64PTK2B1.09305703
65MAP3K11.07795849
66TAOK31.07486118
67MAP3K131.07251047
68DYRK21.06453128
69PNCK1.05199702
70TTK1.02799462
71GRK51.02311229
72EIF2AK31.01443693
73TGFBR10.98869387
74CSNK1G30.98712952
75CSNK1G20.98644559
76RAF10.98397732
77PAK30.98169299
78PAK60.96757726
79CSNK1G10.94974430
80PRKCG0.92680857
81NEK10.91115245
82STK390.90707146
83ZAK0.90461460
84NTRK20.90382448
85LRRK20.90058898
86STK38L0.89699476
87IRAK20.84662940
88IRAK40.83050861
89MYLK0.79778193
90CSNK1A1L0.79416173
91TLK10.79045919
92SIK20.78964963
93TSSK60.78532939
94AURKB0.77045636
95CDK190.74988904
96STK240.73942629
97DYRK1A0.73099396
98MAPKAPK30.72766278
99CAMK2A0.72668233
100CAMK2B0.72445648
101RET0.72208508
102BRSK10.71568509
103PRPF4B0.70899265
104JAK30.70605111
105STK160.68914692
106MARK10.68808092
107PRKCI0.68153004
108TRIB30.68067903
109AURKA0.67731295
110EIF2AK10.67703846
111PIK3CG0.66878176
112CDK140.65447233
113PDGFRA0.63984213
114MAPKAPK50.62381263
115FER0.62235547
116OXSR10.62136960
117PRKCE0.60631779
118DAPK20.60601542
119ATR0.59697400
120DYRK30.59656684
121MUSK0.59630101
122CAMK2D0.54899482
123ADRBK10.54624885
124STK30.53416817
125NME10.52479299
126PRKCH0.52019784
127CDK180.51813143
128RPS6KA40.51777076
129BCR0.51203133
130SYK0.49384773
131PDK30.49169958
132PDK40.49169958
133RPS6KA50.48856037
134PRKD20.48301626
135PTK20.47459580
136ILK0.47187873
137CDC42BPA0.46554079
138CSNK2A20.45830977
139DYRK1B0.45502773
140ADRBK20.45482559
141CCNB10.45283414
142CAMK10.44954335
143IRAK30.44877731
144PDK10.43355670
145SGK10.43256503
146CDK150.43081968
147CSNK2A10.41684791
148PTK60.41460541
149PINK10.41418791
150ATM0.38805413
151MET0.37587068
152CDK11A0.36380179
153ERBB40.36093588
154RPS6KA20.35767549
155PDPK10.35248107
156RPS6KB10.34440301
157CHEK20.32304380
158EPHA30.31702304
159CDK90.31310750
160ABL20.31039290
161CSNK1A10.31030102
162MKNK20.30853891
163ERBB20.29946064
164PRKACA0.29681350
165FGR0.29547946

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.69524994
2Huntingtons disease_Homo sapiens_hsa050163.19139377
3Proteasome_Homo sapiens_hsa030503.00334832
4Parkinsons disease_Homo sapiens_hsa050122.89334366
5Protein export_Homo sapiens_hsa030602.79501213
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.78113149
7Insulin secretion_Homo sapiens_hsa049112.64660297
8Mismatch repair_Homo sapiens_hsa034302.44382055
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35686371
10Long-term potentiation_Homo sapiens_hsa047202.31137134
11Amphetamine addiction_Homo sapiens_hsa050312.26332454
12RNA polymerase_Homo sapiens_hsa030202.09841078
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09432250
14Synaptic vesicle cycle_Homo sapiens_hsa047212.09136741
15Circadian entrainment_Homo sapiens_hsa047132.08789640
16Nicotine addiction_Homo sapiens_hsa050332.02583670
17Olfactory transduction_Homo sapiens_hsa047402.01252820
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.00281776
19Homologous recombination_Homo sapiens_hsa034401.99452877
20Nucleotide excision repair_Homo sapiens_hsa034201.94884590
21Vibrio cholerae infection_Homo sapiens_hsa051101.90921868
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83682783
23DNA replication_Homo sapiens_hsa030301.82045122
24Morphine addiction_Homo sapiens_hsa050321.78645150
25Cocaine addiction_Homo sapiens_hsa050301.77655422
26Propanoate metabolism_Homo sapiens_hsa006401.76720461
27Dopaminergic synapse_Homo sapiens_hsa047281.75530217
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74295346
29Glutathione metabolism_Homo sapiens_hsa004801.73075608
30Base excision repair_Homo sapiens_hsa034101.71608733
31Glutamatergic synapse_Homo sapiens_hsa047241.70186620
32Type I diabetes mellitus_Homo sapiens_hsa049401.67388020
33Spliceosome_Homo sapiens_hsa030401.66848653
34Non-homologous end-joining_Homo sapiens_hsa034501.64779421
35GABAergic synapse_Homo sapiens_hsa047271.64690341
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.60460044
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60322263
38Chemical carcinogenesis_Homo sapiens_hsa052041.59301980
39Basal transcription factors_Homo sapiens_hsa030221.59136601
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55839660
41N-Glycan biosynthesis_Homo sapiens_hsa005101.50156339
42Taste transduction_Homo sapiens_hsa047421.48880505
43beta-Alanine metabolism_Homo sapiens_hsa004101.48205844
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45992686
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45497264
46Cholinergic synapse_Homo sapiens_hsa047251.45023927
47Folate biosynthesis_Homo sapiens_hsa007901.42976641
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41429318
49Collecting duct acid secretion_Homo sapiens_hsa049661.40369287
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39746254
51Fanconi anemia pathway_Homo sapiens_hsa034601.38317646
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38316336
53Serotonergic synapse_Homo sapiens_hsa047261.36215072
54Basal cell carcinoma_Homo sapiens_hsa052171.34420521
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34110478
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32398649
57Hedgehog signaling pathway_Homo sapiens_hsa043401.32067884
58RNA degradation_Homo sapiens_hsa030181.31883760
59Salivary secretion_Homo sapiens_hsa049701.31632174
60Renin secretion_Homo sapiens_hsa049241.31607710
61Steroid biosynthesis_Homo sapiens_hsa001001.31307401
62Pyrimidine metabolism_Homo sapiens_hsa002401.30427706
63Gastric acid secretion_Homo sapiens_hsa049711.29455296
64Phenylalanine metabolism_Homo sapiens_hsa003601.29454870
65Carbohydrate digestion and absorption_Homo sapiens_hsa049731.26489106
66Long-term depression_Homo sapiens_hsa047301.25663642
67RNA transport_Homo sapiens_hsa030131.24457055
68Glycosaminoglycan degradation_Homo sapiens_hsa005311.20068078
69Tyrosine metabolism_Homo sapiens_hsa003501.19631430
70SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17523011
71Estrogen signaling pathway_Homo sapiens_hsa049151.17093520
72Type II diabetes mellitus_Homo sapiens_hsa049301.16857413
73Peroxisome_Homo sapiens_hsa041461.09453362
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08688011
75Histidine metabolism_Homo sapiens_hsa003401.07205198
76Calcium signaling pathway_Homo sapiens_hsa040201.06463174
77Purine metabolism_Homo sapiens_hsa002301.06198148
78Thyroid hormone synthesis_Homo sapiens_hsa049181.05405406
79Gap junction_Homo sapiens_hsa045401.05316048
80cAMP signaling pathway_Homo sapiens_hsa040241.04372353
81Glioma_Homo sapiens_hsa052141.02570180
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00570143
83Pyruvate metabolism_Homo sapiens_hsa006201.00309788
84GnRH signaling pathway_Homo sapiens_hsa049120.99296009
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.98730946
86Oxytocin signaling pathway_Homo sapiens_hsa049210.97407022
87Fatty acid elongation_Homo sapiens_hsa000620.95514763
88Caffeine metabolism_Homo sapiens_hsa002320.94881402
89Butanoate metabolism_Homo sapiens_hsa006500.94563399
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92838154
91Alcoholism_Homo sapiens_hsa050340.92650356
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.91865387
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90900237
94Pancreatic secretion_Homo sapiens_hsa049720.87376161
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86516844
96Metabolic pathways_Homo sapiens_hsa011000.82396616
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82255502
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.80588526
99Other glycan degradation_Homo sapiens_hsa005110.80176560
100Retinol metabolism_Homo sapiens_hsa008300.80116636
101Lysosome_Homo sapiens_hsa041420.79982587
102Glucagon signaling pathway_Homo sapiens_hsa049220.79925931
103Melanogenesis_Homo sapiens_hsa049160.79777060
104Regulation of autophagy_Homo sapiens_hsa041400.79525928
105Hippo signaling pathway_Homo sapiens_hsa043900.79326211
106Fatty acid degradation_Homo sapiens_hsa000710.78965093
107Linoleic acid metabolism_Homo sapiens_hsa005910.77244577
108Tryptophan metabolism_Homo sapiens_hsa003800.76169417
109Circadian rhythm_Homo sapiens_hsa047100.75809550
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74345695
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73403448
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72283586
113Prolactin signaling pathway_Homo sapiens_hsa049170.70555739
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69760638
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69637365
116Dorso-ventral axis formation_Homo sapiens_hsa043200.68188612
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.65478440
118Sulfur metabolism_Homo sapiens_hsa009200.65090414
119Oocyte meiosis_Homo sapiens_hsa041140.63737267
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63525964
121ErbB signaling pathway_Homo sapiens_hsa040120.61199385
122VEGF signaling pathway_Homo sapiens_hsa043700.60557819
123Rheumatoid arthritis_Homo sapiens_hsa053230.60285647
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60270691
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59939809
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59586272
127Phagosome_Homo sapiens_hsa041450.59187970
128Tight junction_Homo sapiens_hsa045300.58505252
129Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57995685
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57825687
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57354260
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56393895
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56257964
134Alzheimers disease_Homo sapiens_hsa050100.56041482
135Selenocompound metabolism_Homo sapiens_hsa004500.55359931
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54479091
137Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54452205
138Phototransduction_Homo sapiens_hsa047440.53795927
139Chemokine signaling pathway_Homo sapiens_hsa040620.50941619
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.48885346
141Non-small cell lung cancer_Homo sapiens_hsa052230.47327290
142Cell cycle_Homo sapiens_hsa041100.47324237
143Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47216920
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.47171884
145Tuberculosis_Homo sapiens_hsa051520.46490140
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.45907886
147MAPK signaling pathway_Homo sapiens_hsa040100.45637930
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45268656
149Arachidonic acid metabolism_Homo sapiens_hsa005900.44825322
150Choline metabolism in cancer_Homo sapiens_hsa052310.44266464
151TGF-beta signaling pathway_Homo sapiens_hsa043500.43113591
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42178998
153African trypanosomiasis_Homo sapiens_hsa051430.42106421
154Cardiac muscle contraction_Homo sapiens_hsa042600.41884085
155Wnt signaling pathway_Homo sapiens_hsa043100.41696997
156Inositol phosphate metabolism_Homo sapiens_hsa005620.41532068
157p53 signaling pathway_Homo sapiens_hsa041150.41515002
158Nitrogen metabolism_Homo sapiens_hsa009100.41472457
159Arginine and proline metabolism_Homo sapiens_hsa003300.39863945
160Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39751417
161Ras signaling pathway_Homo sapiens_hsa040140.38855970
162Shigellosis_Homo sapiens_hsa051310.38806889
163Thyroid cancer_Homo sapiens_hsa052160.38793948
164One carbon pool by folate_Homo sapiens_hsa006700.38751854
165Asthma_Homo sapiens_hsa053100.38660241
166Endometrial cancer_Homo sapiens_hsa052130.38611574
167Sphingolipid metabolism_Homo sapiens_hsa006000.38378564
168Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36680574
169Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35984203
170Dilated cardiomyopathy_Homo sapiens_hsa054140.35276759
171Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33918997
172mTOR signaling pathway_Homo sapiens_hsa041500.32207992
173Oxidative phosphorylation_Homo sapiens_hsa001900.31958189
174Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30556784
175Sulfur relay system_Homo sapiens_hsa041220.26453819
176mRNA surveillance pathway_Homo sapiens_hsa030150.22519277
177Fatty acid metabolism_Homo sapiens_hsa012120.20661618

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