IFT74

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.23130002
2axonemal dynein complex assembly (GO:0070286)7.94699035
3cilium movement (GO:0003341)7.28757220
4epithelial cilium movement (GO:0003351)6.66756036
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.96738773
6* intraciliary transport (GO:0042073)5.87865689
7piRNA metabolic process (GO:0034587)5.29235631
8axoneme assembly (GO:0035082)5.17056988
9motile cilium assembly (GO:0044458)4.78476774
10regulation of cilium movement (GO:0003352)4.70022328
11GTP biosynthetic process (GO:0006183)4.68509884
12fusion of sperm to egg plasma membrane (GO:0007342)4.67501251
13male meiosis (GO:0007140)4.52794960
14guanosine-containing compound biosynthetic process (GO:1901070)4.33498921
15ventricular system development (GO:0021591)4.26743786
16sperm motility (GO:0030317)4.24730162
17sperm-egg recognition (GO:0035036)4.22963648
18spermatid development (GO:0007286)4.18934240
19synaptonemal complex organization (GO:0070193)4.13345666
20binding of sperm to zona pellucida (GO:0007339)4.13337431
21protein localization to cilium (GO:0061512)4.12371982
22acrosome assembly (GO:0001675)4.10872055
23UTP biosynthetic process (GO:0006228)4.10838393
24* cilium organization (GO:0044782)3.91405612
25cilium morphogenesis (GO:0060271)3.89906028
26centriole replication (GO:0007099)3.86610594
27* cilium assembly (GO:0042384)3.84524481
28DNA methylation involved in gamete generation (GO:0043046)3.80419386
29resolution of meiotic recombination intermediates (GO:0000712)3.80049549
30nucleoside diphosphate phosphorylation (GO:0006165)3.74593717
31synaptonemal complex assembly (GO:0007130)3.73371651
32multicellular organism reproduction (GO:0032504)3.68892705
33replication fork processing (GO:0031297)3.63763721
34cell-cell recognition (GO:0009988)3.57233119
35cell wall macromolecule metabolic process (GO:0044036)3.55673143
36cell wall macromolecule catabolic process (GO:0016998)3.55673143
37male meiosis I (GO:0007141)3.53498537
38microtubule severing (GO:0051013)3.48831220
39plasma membrane fusion (GO:0045026)3.47788216
40acrosome reaction (GO:0007340)3.46220179
41DNA double-strand break processing (GO:0000729)3.45924064
42UTP metabolic process (GO:0046051)3.43325294
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.42358570
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.41745675
45cullin deneddylation (GO:0010388)3.39594128
46microtubule depolymerization (GO:0007019)3.31141612
47meiotic nuclear division (GO:0007126)3.21806416
48intra-S DNA damage checkpoint (GO:0031573)3.21080831
49single fertilization (GO:0007338)3.17739213
50RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.14849904
51centriole assembly (GO:0098534)3.13098357
52* cellular component assembly involved in morphogenesis (GO:0010927)3.11253240
53CTP metabolic process (GO:0046036)3.10039639
54CTP biosynthetic process (GO:0006241)3.10039639
55respiratory chain complex IV assembly (GO:0008535)3.06137502
56negative regulation of DNA-dependent DNA replication (GO:2000104)3.05668362
57synapsis (GO:0007129)3.05597678
58water-soluble vitamin biosynthetic process (GO:0042364)3.03709118
59regulation of centriole replication (GO:0046599)3.03370025
60histone H2A acetylation (GO:0043968)3.02444674
61pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.01069393
62protein neddylation (GO:0045116)2.98568941
63response to pheromone (GO:0019236)2.98390172
64chromosome organization involved in meiosis (GO:0070192)2.96673712
65protein complex biogenesis (GO:0070271)2.93922638
66kinetochore assembly (GO:0051382)2.93777534
67neuron fate determination (GO:0048664)2.92737156
68meiosis I (GO:0007127)2.90675798
69tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90095190
70RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90095190
71protein deneddylation (GO:0000338)2.88821550
72proteasome assembly (GO:0043248)2.87936488
73protein prenylation (GO:0018342)2.86464446
74prenylation (GO:0097354)2.86464446
75nonmotile primary cilium assembly (GO:0035058)2.85830775
76seminiferous tubule development (GO:0072520)2.83745359
77meiotic cell cycle (GO:0051321)2.83324144
78left/right axis specification (GO:0070986)2.82411491
79nuclear pore complex assembly (GO:0051292)2.82032638
80mitochondrial respiratory chain complex assembly (GO:0033108)2.81341018
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80771582
82mitochondrial respiratory chain complex I assembly (GO:0032981)2.80771582
83NADH dehydrogenase complex assembly (GO:0010257)2.80771582
84recombinational repair (GO:0000725)2.80473971
85peptidyl-histidine modification (GO:0018202)2.80001972
86protein polyglutamylation (GO:0018095)2.79581517
87* microtubule-based movement (GO:0007018)2.78353920
88pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.78311895
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.78294226
90regulation of meiosis I (GO:0060631)2.77981834
91establishment of protein localization to mitochondrial membrane (GO:0090151)2.77850922
92double-strand break repair via homologous recombination (GO:0000724)2.76056134
93regulation of microtubule-based movement (GO:0060632)2.73319760
94spermatid nucleus differentiation (GO:0007289)2.71367999
95nuclear pore organization (GO:0006999)2.71245202
96microtubule bundle formation (GO:0001578)2.70970100
97kinetochore organization (GO:0051383)2.70845729
98positive regulation of mitochondrial fission (GO:0090141)2.70751443
99purine nucleobase biosynthetic process (GO:0009113)2.68506852
100histone exchange (GO:0043486)2.66316550
101left/right pattern formation (GO:0060972)2.66127342
102neural tube formation (GO:0001841)2.65059177
103fertilization (GO:0009566)2.62811040
104reproduction (GO:0000003)2.60478629
105chromatin remodeling at centromere (GO:0031055)2.59087386
106branched-chain amino acid catabolic process (GO:0009083)2.58333653
107smoothened signaling pathway (GO:0007224)2.57303833
108pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.56749698
109cytochrome complex assembly (GO:0017004)2.55887103
110limb bud formation (GO:0060174)2.54975009
111rRNA catabolic process (GO:0016075)2.54169977
112detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52919299
113platelet dense granule organization (GO:0060155)2.51998560
114male gamete generation (GO:0048232)2.51360034
115spermatogenesis (GO:0007283)2.51210805
116aldehyde catabolic process (GO:0046185)2.50579272
117organelle disassembly (GO:1903008)2.50400151
118determination of left/right symmetry (GO:0007368)2.50170698
1197-methylguanosine RNA capping (GO:0009452)2.49255184
120RNA capping (GO:0036260)2.49255184
121CENP-A containing nucleosome assembly (GO:0034080)2.47573082
122germ cell development (GO:0007281)2.47449605
123regulation of DNA endoreduplication (GO:0032875)2.47082219
124photoreceptor cell maintenance (GO:0045494)2.46973086
1257-methylguanosine mRNA capping (GO:0006370)2.46612217
126mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.46584047
127telomere maintenance via telomerase (GO:0007004)2.46118131
128determination of bilateral symmetry (GO:0009855)2.45505545
129specification of symmetry (GO:0009799)2.44936982
130establishment of integrated proviral latency (GO:0075713)2.43575201
131mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.43469312
132inositol phosphate catabolic process (GO:0071545)2.43017226
133meiotic chromosome segregation (GO:0045132)2.42690982
134DNA damage response, detection of DNA damage (GO:0042769)2.41537498
135regulation of nuclear cell cycle DNA replication (GO:0033262)2.40255852
136inositol phosphate dephosphorylation (GO:0046855)2.38064212
137phosphorylated carbohydrate dephosphorylation (GO:0046838)2.38064212
138DNA replication-independent nucleosome organization (GO:0034724)2.38019453
139DNA replication-independent nucleosome assembly (GO:0006336)2.38019453
140reciprocal meiotic recombination (GO:0007131)2.37912115
141reciprocal DNA recombination (GO:0035825)2.37912115
142nucleobase biosynthetic process (GO:0046112)2.37439165
143histone mRNA metabolic process (GO:0008334)2.36935782
144positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.36849020
145positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.36849020
146positive regulation of mitotic sister chromatid separation (GO:1901970)2.36849020
147response to X-ray (GO:0010165)2.36681269
148otic vesicle formation (GO:0030916)2.36361892
149gamete generation (GO:0007276)2.36326119
150mismatch repair (GO:0006298)2.36311141
151regulation of hexokinase activity (GO:1903299)2.36257848
152regulation of glucokinase activity (GO:0033131)2.36257848
153pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.35959978
154microtubule polymerization or depolymerization (GO:0031109)2.33614054
155GPI anchor metabolic process (GO:0006505)2.33219237
156deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.33134305
157DNA ligation (GO:0006266)2.33090966
158regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.31599794
159DNA catabolic process, exonucleolytic (GO:0000738)2.28429455
160anterograde synaptic vesicle transport (GO:0048490)2.28014412
161lactate metabolic process (GO:0006089)2.27119645
162ATP synthesis coupled proton transport (GO:0015986)2.25985014
163energy coupled proton transport, down electrochemical gradient (GO:0015985)2.25985014
164centrosome organization (GO:0051297)2.24055658

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.60057445
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.37146276
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.47595113
4EZH2_22144423_ChIP-Seq_EOC_Human3.07977756
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.74714660
6FUS_26573619_Chip-Seq_HEK293_Human2.56541452
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56311318
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.56150938
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.09276665
10RNF2_27304074_Chip-Seq_NSC_Mouse2.07512970
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06688720
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.05873507
13VDR_22108803_ChIP-Seq_LS180_Human1.99552537
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96652837
15GBX2_23144817_ChIP-Seq_PC3_Human1.93654014
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91788396
17CBX2_27304074_Chip-Seq_ESCs_Mouse1.90064056
18E2F7_22180533_ChIP-Seq_HELA_Human1.88622091
19E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79234256
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77663968
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.77418236
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77125492
23TAF15_26573619_Chip-Seq_HEK293_Human1.70279821
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70255370
25EWS_26573619_Chip-Seq_HEK293_Human1.70054794
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69748864
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.69146903
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65892717
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63124932
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60339249
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59147187
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58494697
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57979092
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56463053
35DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.54516532
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53223206
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53216890
38ZNF274_21170338_ChIP-Seq_K562_Hela1.47873212
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.43681538
40* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43598809
41MYC_18940864_ChIP-ChIP_HL60_Human1.40744224
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39604479
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38642154
44P300_19829295_ChIP-Seq_ESCs_Human1.37163957
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36776531
46FOXP3_21729870_ChIP-Seq_TREG_Human1.35623214
47ELK1_19687146_ChIP-ChIP_HELA_Human1.35444796
48CBP_20019798_ChIP-Seq_JUKART_Human1.34645296
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34645296
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34036051
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32233164
52ER_23166858_ChIP-Seq_MCF-7_Human1.31376316
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31098534
54IGF1R_20145208_ChIP-Seq_DFB_Human1.29197447
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27743106
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.26874857
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26588043
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26296920
59AR_25329375_ChIP-Seq_VCAP_Human1.26058685
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25973058
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25022330
62BCAT_22108803_ChIP-Seq_LS180_Human1.24144563
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23171853
64SOX2_19829295_ChIP-Seq_ESCs_Human1.22985405
65NANOG_19829295_ChIP-Seq_ESCs_Human1.22985405
66SOX9_26525672_Chip-Seq_HEART_Mouse1.22143040
67STAT3_23295773_ChIP-Seq_U87_Human1.20965866
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20121612
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.19424721
70KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18905098
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18767262
72* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18640251
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17830417
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17461198
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17046990
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16931680
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16884125
78* SMAD4_21799915_ChIP-Seq_A2780_Human1.16721785
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16641442
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14816248
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.12997622
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12694151
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.12277105
84TCF4_22108803_ChIP-Seq_LS180_Human1.12028244
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11956344
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11238684
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10724253
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.10526124
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10329282
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.10137681
91CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09534755
92* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09481364
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09451423
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09090960
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08821926
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08723566
97* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08113138
98TP53_22573176_ChIP-Seq_HFKS_Human1.07454681
99FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07215289
100SOX2_16153702_ChIP-ChIP_HESCs_Human1.06948060
101TCF4_23295773_ChIP-Seq_U87_Human1.06812845
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05095952
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04910749
104FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04114410
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.03757183
106SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.03427318
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.03268734
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02911710
109RUNX2_22187159_ChIP-Seq_PCA_Human1.02855725
110P53_22387025_ChIP-Seq_ESCs_Mouse1.02492612
111ETS1_20019798_ChIP-Seq_JURKAT_Human1.02198857
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.00953202
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00183492
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.00167357
115FOXA1_25329375_ChIP-Seq_VCAP_Human1.00146982
116FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00146982
117NANOG_16153702_ChIP-ChIP_HESCs_Human1.00038101
118FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99507127
119CMYC_18555785_Chip-Seq_ESCs_Mouse0.99442928
120CDX2_22108803_ChIP-Seq_LS180_Human0.98882389
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98150774
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97816240
123* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95873327
124P300_18555785_Chip-Seq_ESCs_Mouse0.95271710
125SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95233304
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94775074
127TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94322521
128MYC_18555785_ChIP-Seq_MESCs_Mouse0.94165899
129EZH2_27294783_Chip-Seq_NPCs_Mouse0.93364740
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93346065
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93094626
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93094626
133VDR_23849224_ChIP-Seq_CD4+_Human0.92877436
134SOX2_18555785_Chip-Seq_ESCs_Mouse0.92371093
135RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92183722
136IRF1_19129219_ChIP-ChIP_H3396_Human0.92099980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization3.73743317
2MP0008877_abnormal_DNA_methylation3.56869863
3MP0002837_dystrophic_cardiac_calcinosis2.92363107
4MP0003787_abnormal_imprinting2.89521563
5MP0008057_abnormal_DNA_replication2.68844677
6MP0003121_genomic_imprinting2.49203451
7MP0002653_abnormal_ependyma_morphology2.45820036
8MP0003123_paternal_imprinting2.33631542
9MP0006292_abnormal_olfactory_placode2.21772112
10MP0003698_abnormal_male_reproductive2.21294878
11MP0003122_maternal_imprinting2.18613350
12MP0001929_abnormal_gametogenesis2.16209687
13MP0002210_abnormal_sex_determination2.14026070
14MP0002160_abnormal_reproductive_system2.03760112
15MP0008058_abnormal_DNA_repair2.01450873
16MP0005084_abnormal_gallbladder_morpholo1.97947984
17MP0002876_abnormal_thyroid_physiology1.93091963
18MP0001984_abnormal_olfaction1.90969400
19MP0003718_maternal_effect1.90143664
20MP0005503_abnormal_tendon_morphology1.86717293
21MP0004133_heterotaxia1.83657520
22MP0005623_abnormal_meninges_morphology1.82018355
23MP0003136_yellow_coat_color1.80379071
24MP0010030_abnormal_orbit_morphology1.77856328
25MP0002938_white_spotting1.77621189
26MP0010094_abnormal_chromosome_stability1.77453293
27MP0008007_abnormal_cellular_replicative1.69863611
28MP0003195_calcinosis1.66243047
29MP0003942_abnormal_urinary_system1.66085947
30MP0001145_abnormal_male_reproductive1.65602567
31MP0003890_abnormal_embryonic-extraembry1.61848493
32MP0001188_hyperpigmentation1.58919734
33MP0000049_abnormal_middle_ear1.54708902
34MP0008789_abnormal_olfactory_epithelium1.53399884
35MP0005389_reproductive_system_phenotype1.51727296
36MP0008932_abnormal_embryonic_tissue1.50964137
37MP0004142_abnormal_muscle_tone1.50025627
38MP0000653_abnormal_sex_gland1.49922875
39MP0009379_abnormal_foot_pigmentation1.49383078
40MP0000427_abnormal_hair_cycle1.49368362
41MP0003567_abnormal_fetal_cardiomyocyte1.45010640
42MP0000778_abnormal_nervous_system1.44812532
43MP0003937_abnormal_limbs/digits/tail_de1.44512958
44MP0002282_abnormal_trachea_morphology1.43854182
45MP0004147_increased_porphyrin_level1.42115745
46MP0006072_abnormal_retinal_apoptosis1.41518792
47MP0009250_abnormal_appendicular_skeleto1.41432915
48MP0009697_abnormal_copulation1.40031072
49MP0000631_abnormal_neuroendocrine_gland1.38178175
50MP0005646_abnormal_pituitary_gland1.35390983
51MP0000647_abnormal_sebaceous_gland1.34301937
52MP0002638_abnormal_pupillary_reflex1.32987910
53MP0006035_abnormal_mitochondrial_morpho1.31155718
54MP0002233_abnormal_nose_morphology1.31052156
55MP0008875_abnormal_xenobiotic_pharmacok1.30370226
56MP0004215_abnormal_myocardial_fiber1.28943541
57MP0005248_abnormal_Harderian_gland1.28744211
58MP0000383_abnormal_hair_follicle1.26895218
59MP0003385_abnormal_body_wall1.26806097
60MP0003755_abnormal_palate_morphology1.23763902
61MP0001485_abnormal_pinna_reflex1.22929311
62MP0003077_abnormal_cell_cycle1.21701662
63MP0010678_abnormal_skin_adnexa1.21513482
64MP0008775_abnormal_heart_ventricle1.21305722
65MP0002161_abnormal_fertility/fecundity1.21107380
66MP0005171_absent_coat_pigmentation1.18242990
67MP0005394_taste/olfaction_phenotype1.16164715
68MP0005499_abnormal_olfactory_system1.16164715
69MP0004885_abnormal_endolymph1.15785785
70MP0004957_abnormal_blastocyst_morpholog1.13381090
71MP0005174_abnormal_tail_pigmentation1.13092689
72MP0001764_abnormal_homeostasis1.11549637
73MP0002928_abnormal_bile_duct1.09779873
74MP0003186_abnormal_redox_activity1.09338136
75MP0000372_irregular_coat_pigmentation1.08881489
76MP0002751_abnormal_autonomic_nervous1.06959296
77MP0005551_abnormal_eye_electrophysiolog1.04801733
78MP0005195_abnormal_posterior_eye1.03923147
79MP0005253_abnormal_eye_physiology1.02904275
80MP0005367_renal/urinary_system_phenotyp1.02901952
81MP0000516_abnormal_urinary_system1.02901952
82MP0001293_anophthalmia1.00703988
83MP0002116_abnormal_craniofacial_bone1.00652751
84MP0003693_abnormal_embryo_hatching1.00451340
85MP0003315_abnormal_perineum_morphology0.99737301
86MP0003938_abnormal_ear_development0.99129599
87MP0001919_abnormal_reproductive_system0.98864290
88MP0010386_abnormal_urinary_bladder0.96716827
89MP0002095_abnormal_skin_pigmentation0.96462323
90MP0006276_abnormal_autonomic_nervous0.96310713
91MP0003861_abnormal_nervous_system0.96183665
92MP0001286_abnormal_eye_development0.94950038
93MP0003880_abnormal_central_pattern0.94110483
94MP0006036_abnormal_mitochondrial_physio0.94081226
95MP0002234_abnormal_pharynx_morphology0.93745730
96MP0001986_abnormal_taste_sensitivity0.92961225
97MP0002163_abnormal_gland_morphology0.92890916
98MP0001529_abnormal_vocalization0.92881535
99MP0000534_abnormal_ureter_morphology0.91275343
100MP0002249_abnormal_larynx_morphology0.91176491
101MP0000569_abnormal_digit_pigmentation0.90099632
102MP0001324_abnormal_eye_pigmentation0.89501479
103MP0002184_abnormal_innervation0.89130876
104MP0004043_abnormal_pH_regulation0.88028437
105MP0005645_abnormal_hypothalamus_physiol0.87527725
106MP0003786_premature_aging0.85091714
107MP0003115_abnormal_respiratory_system0.84999262
108MP0000566_synostosis0.84498035
109MP0003283_abnormal_digestive_organ0.84361695
110MP0002090_abnormal_vision0.83976646
111MP0002734_abnormal_mechanical_nocicepti0.83932814
112MP0003943_abnormal_hepatobiliary_system0.83465675
113MP0008995_early_reproductive_senescence0.83437341
114MP0002084_abnormal_developmental_patter0.83061332
115MP0002102_abnormal_ear_morphology0.82892930
116MP0000432_abnormal_head_morphology0.82429216
117MP0002109_abnormal_limb_morphology0.82343817
118MP0000013_abnormal_adipose_tissue0.81807272
119MP0005391_vision/eye_phenotype0.81680664
120MP0000428_abnormal_craniofacial_morphol0.81236259
121MP0005379_endocrine/exocrine_gland_phen0.80122176
122MP0003111_abnormal_nucleus_morphology0.79909826
123MP0001905_abnormal_dopamine_level0.79501884
124MP0004084_abnormal_cardiac_muscle0.79261310
125MP0002177_abnormal_outer_ear0.78938674
126MP0005187_abnormal_penis_morphology0.78799318
127MP0008872_abnormal_physiological_respon0.78672005
128MP0000026_abnormal_inner_ear0.78617436
129MP0002736_abnormal_nociception_after0.77055315
130MP0001968_abnormal_touch/_nociception0.77040000
131MP0002752_abnormal_somatic_nervous0.75940775
132MP0001177_atelectasis0.75872108
133MP0000639_abnormal_adrenal_gland0.75770448
134MP0002697_abnormal_eye_size0.75749252
135MP0000358_abnormal_cell_content/0.75342483
136MP0009053_abnormal_anal_canal0.74815091
137MP0002152_abnormal_brain_morphology0.74610335
138MP0002572_abnormal_emotion/affect_behav0.74368799
139MP0009046_muscle_twitch0.73308108
140MP0002114_abnormal_axial_skeleton0.72586525

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.08200904
2Abnormal respiratory motile cilium physiology (HP:0012261)7.56395961
3Abnormal ciliary motility (HP:0012262)7.41718605
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.57813118
5Absent/shortened dynein arms (HP:0200106)6.57813118
6Abnormal respiratory motile cilium morphology (HP:0005938)6.51022162
7Abnormal respiratory epithelium morphology (HP:0012253)6.51022162
8Rhinitis (HP:0012384)5.96459778
9Chronic bronchitis (HP:0004469)4.30146984
10True hermaphroditism (HP:0010459)4.21422489
11Pancreatic fibrosis (HP:0100732)4.18768183
12Nephronophthisis (HP:0000090)3.92604043
13Medial flaring of the eyebrow (HP:0010747)3.92230397
14Molar tooth sign on MRI (HP:0002419)3.77225734
15Abnormality of midbrain morphology (HP:0002418)3.77225734
16Congenital primary aphakia (HP:0007707)3.54038953
17Gait imbalance (HP:0002141)3.46610579
18Supernumerary spleens (HP:0009799)3.30982405
19Nephrogenic diabetes insipidus (HP:0009806)3.23205457
20Pancreatic cysts (HP:0001737)3.20305236
21Occipital encephalocele (HP:0002085)3.18289241
22Bronchiectasis (HP:0002110)3.10005421
23Postaxial foot polydactyly (HP:0001830)3.08192705
24Facial cleft (HP:0002006)3.06891138
25Abnormality of dentin (HP:0010299)3.05633213
26Infertility (HP:0000789)3.04530596
27Aplasia/Hypoplasia of the tongue (HP:0010295)3.00584195
28Tubulointerstitial nephritis (HP:0001970)3.00452176
29Abnormality of the renal medulla (HP:0100957)2.93251388
30Intestinal atresia (HP:0011100)2.90241899
31Median cleft lip (HP:0000161)2.88344103
32Septo-optic dysplasia (HP:0100842)2.86204579
33Abnormality of the labia minora (HP:0012880)2.83274947
34Genital tract atresia (HP:0001827)2.82361067
35Poor coordination (HP:0002370)2.75604762
36Vaginal atresia (HP:0000148)2.71520049
37Hyperglycinemia (HP:0002154)2.61752183
38Cystic liver disease (HP:0006706)2.61450049
39Postaxial hand polydactyly (HP:0001162)2.55502249
40Fibular hypoplasia (HP:0003038)2.54349896
41Colon cancer (HP:0003003)2.50355987
42Preaxial hand polydactyly (HP:0001177)2.49959747
43Embryonal renal neoplasm (HP:0011794)2.41737003
44Nephroblastoma (Wilms tumor) (HP:0002667)2.40705074
45Acute encephalopathy (HP:0006846)2.40338853
46Aplasia/Hypoplasia of the lens (HP:0008063)2.32545260
47Congenital hepatic fibrosis (HP:0002612)2.30081076
48Male pseudohermaphroditism (HP:0000037)2.29766886
49Anencephaly (HP:0002323)2.27780740
50Optic nerve hypoplasia (HP:0000609)2.26449263
51Bifid tongue (HP:0010297)2.26382626
52Abnormality of the renal cortex (HP:0011035)2.24390111
53Male infertility (HP:0003251)2.22786335
54Mitochondrial inheritance (HP:0001427)2.18306442
55Sclerocornea (HP:0000647)2.16635013
56Hypoplasia of the pons (HP:0012110)2.15593883
57Methylmalonic acidemia (HP:0002912)2.13977957
5811 pairs of ribs (HP:0000878)2.13920776
59Increased CSF lactate (HP:0002490)2.12255960
60Microglossia (HP:0000171)2.11780851
61Hypoproteinemia (HP:0003075)2.11405976
62Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.11108103
63Abnormality of the pons (HP:0007361)2.06593267
64Lipid accumulation in hepatocytes (HP:0006561)2.01446086
65Gastrointestinal atresia (HP:0002589)2.01222174
66Volvulus (HP:0002580)2.01127621
67Hypoplastic pelvis (HP:0008839)1.97276549
68Aplasia/Hypoplasia of the fibula (HP:0006492)1.94265690
69B lymphocytopenia (HP:0010976)1.94246369
70Type II lissencephaly (HP:0007260)1.94147438
71Increased hepatocellular lipid droplets (HP:0006565)1.93854318
72Oligodactyly (hands) (HP:0001180)1.93621247
73Hyperglycinuria (HP:0003108)1.90960411
74Broad foot (HP:0001769)1.88815981
75Chronic hepatic failure (HP:0100626)1.87458649
76Renal cortical cysts (HP:0000803)1.87075995
77Oculomotor apraxia (HP:0000657)1.85669203
78Adrenal hypoplasia (HP:0000835)1.84683453
79Absent septum pellucidum (HP:0001331)1.83993726
80Decreased testicular size (HP:0008734)1.81378132
81Chromsome breakage (HP:0040012)1.81260517
82Thyroiditis (HP:0100646)1.80516361
83Hypothermia (HP:0002045)1.80286290
84Broad distal phalanx of finger (HP:0009836)1.80098005
85Lissencephaly (HP:0001339)1.80051174
86Abnormality of serine family amino acid metabolism (HP:0010894)1.80006717
87Abnormality of glycine metabolism (HP:0010895)1.80006717
88Aganglionic megacolon (HP:0002251)1.79829009
89Acute necrotizing encephalopathy (HP:0006965)1.79491774
90Hepatocellular necrosis (HP:0001404)1.79469596
91Abnormality of chromosome stability (HP:0003220)1.79309916
92Sloping forehead (HP:0000340)1.79160553
93Aplasia/Hypoplasia of the uvula (HP:0010293)1.78476848
94Congenital, generalized hypertrichosis (HP:0004540)1.77318843
95Cerebral edema (HP:0002181)1.77110504
96Stage 5 chronic kidney disease (HP:0003774)1.76891750
97Congenital stationary night blindness (HP:0007642)1.76293720
98Hepatic necrosis (HP:0002605)1.76015373
99Cerebellar dysplasia (HP:0007033)1.74995195
100Bronchitis (HP:0012387)1.73905181
101Abolished electroretinogram (ERG) (HP:0000550)1.73275264
102Abnormality of the ileum (HP:0001549)1.72814092
103Abnormality of B cell number (HP:0010975)1.72790248
104Anophthalmia (HP:0000528)1.72577974
105Abnormality of the anterior horn cell (HP:0006802)1.71950805
106Degeneration of anterior horn cells (HP:0002398)1.71950805
107Meckel diverticulum (HP:0002245)1.71738415
108Chronic sinusitis (HP:0011109)1.69722988
109Tubular atrophy (HP:0000092)1.69403955
110Hepatoblastoma (HP:0002884)1.64917392
111Missing ribs (HP:0000921)1.63875356
112Short foot (HP:0001773)1.63103571
113Aplasia/Hypoplasia of the tibia (HP:0005772)1.62502795
114Short nail (HP:0001799)1.60131095
115Abnormality of the dental root (HP:0006486)1.60076897
116Taurodontia (HP:0000679)1.60076897
117Abnormality of permanent molar morphology (HP:0011071)1.60076897
118Dental crowding (HP:0000678)1.59489597
119Multicystic kidney dysplasia (HP:0000003)1.58947627
120Renal dysplasia (HP:0000110)1.57547484
121Narrow forehead (HP:0000341)1.54801629
122Prominent nasal bridge (HP:0000426)1.54029973
123Progressive macrocephaly (HP:0004481)1.53854002
124Nasal polyposis (HP:0100582)1.52632804
125Abnormality of molar (HP:0011077)1.52502055
126Abnormality of molar morphology (HP:0011070)1.52502055
127Abnormality of the dental pulp (HP:0006479)1.49725372
128Tubulointerstitial abnormality (HP:0001969)1.49460929
129Short ribs (HP:0000773)1.47833375
130Abnormal mitochondria in muscle tissue (HP:0008316)1.46981015
131Bile duct proliferation (HP:0001408)1.45591575
132Abnormal biliary tract physiology (HP:0012439)1.45591575
133Abnormal lung lobation (HP:0002101)1.45424700
134Furrowed tongue (HP:0000221)1.44460103
135Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.44453084
136Short tibia (HP:0005736)1.43831173
137Abnormality of renal resorption (HP:0011038)1.43822600
138Papillary thyroid carcinoma (HP:0002895)1.41960260
139Absent frontal sinuses (HP:0002688)1.41181462
140Bell-shaped thorax (HP:0001591)1.40919524
141Specific learning disability (HP:0001328)1.40548936
142Ectopic anus (HP:0004397)1.39720393
143Retinal dysplasia (HP:0007973)1.39513031
144Astigmatism (HP:0000483)1.38176962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.54990697
2MAP4K23.01963405
3PDK33.00310248
4PDK43.00310248
5CASK2.59342500
6BUB12.57018134
7WEE12.56896705
8CDC72.50303191
9STK162.47363184
10PRKD32.42227789
11PLK42.27890621
12PASK2.16262826
13PLK22.15021292
14MAPK152.10167736
15SRPK12.08915145
16ERBB31.96657770
17PLK31.84190507
18NEK11.83050236
19BRSK11.81270952
20PDK21.78984183
21VRK11.74622341
22TSSK61.70755006
23AKT31.67316156
24BRSK21.66429721
25CCNB11.65459773
26FRK1.63497054
27MKNK11.63302702
28GRK11.62568406
29VRK21.61978287
30STK38L1.61394358
31BCR1.61180343
32MKNK21.60886658
33TRIM281.60266625
34MAP2K71.59345851
35EIF2AK11.55969139
36MAPK131.54014972
37NEK61.47984435
38TAF11.36913341
39NME11.35623950
40ZAK1.28053849
41PINK11.23445109
42CSNK1G11.20646847
43STK31.20177522
44BCKDK1.19328337
45BMPR21.14803865
46TIE11.14654126
47PLK11.13547261
48MAP3K41.12251590
49TESK11.11726308
50MST41.11672727
51ATR1.11529706
52STK391.10039863
53WNK41.06217299
54WNK31.04360179
55BRAF1.01515379
56YES11.01125859
57TNIK0.96520502
58CSNK1G20.95224384
59PTK2B0.95063383
60CHEK20.92914358
61LATS10.92891241
62NTRK30.92225816
63NUAK10.89660140
64TTK0.87602847
65DYRK20.87204318
66CDK80.87005393
67TAOK30.86181098
68FGFR20.84555698
69DYRK30.84454527
70SGK20.81142964
71WNK10.80327167
72ATM0.76429590
73CDK30.75189621
74MUSK0.74368672
75CSNK1A1L0.73580990
76AURKA0.73284697
77PBK0.71724529
78BMPR1B0.71649807
79OXSR10.71421976
80CHEK10.70761209
81RPS6KA40.68119575
82PAK30.67231533
83IRAK10.66402821
84PIK3CA0.64088069
85NEK20.63565196
86PRKCG0.59597030
87NLK0.59175752
88MAP3K120.58972075
89MINK10.58820310
90FLT30.58743373
91EPHA40.58355840
92ACVR1B0.57659569
93CSNK2A10.55529621
94ADRBK10.53304582
95SGK4940.51198578
96SGK2230.51198578
97AURKB0.49772354
98DYRK1A0.49714289
99CSNK2A20.48262995
100EIF2AK30.48100187
101CDK10.46675337
102STK240.43278834
103GRK50.42252535
104LIMK10.41459995
105BRD40.40907089
106LATS20.40759253
107CDK70.40601884
108TEC0.40575586
109UHMK10.40297039
110CDK140.39760460
111CDK180.39436345
112SIK30.39378965
113RPS6KB10.38513864
114IRAK20.38293222
115FER0.37603220
116PRKCE0.37186512
117ADRBK20.36922322
118MELK0.36250617
119CDK20.36218312
120EPHB20.36089301
121CDK190.36049458
122TAOK20.35982573
123RPS6KA50.33285825
124INSRR0.33151101
125EIF2AK20.32315756
126CSNK1G30.32007387
127MAP3K30.32000291
128CSNK1A10.31755834
129CSNK1E0.31029612
130CDK150.29200908
131TGFBR10.29118228
132PRKACB0.27958475
133CAMK2A0.27127887
134FGFR10.26874578
135PRKG10.26835058
136PRKACA0.26244910
137DAPK20.25832768

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.21086467
2Protein export_Homo sapiens_hsa030602.77937349
3Mismatch repair_Homo sapiens_hsa034302.62987094
4Proteasome_Homo sapiens_hsa030502.57758124
5Propanoate metabolism_Homo sapiens_hsa006402.56485008
6Nucleotide excision repair_Homo sapiens_hsa034202.53256646
7RNA polymerase_Homo sapiens_hsa030202.50004150
8Huntingtons disease_Homo sapiens_hsa050162.46821077
9Spliceosome_Homo sapiens_hsa030402.31175624
10Fanconi anemia pathway_Homo sapiens_hsa034602.29220520
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24837798
12Cell cycle_Homo sapiens_hsa041102.20602464
13DNA replication_Homo sapiens_hsa030302.19896185
14RNA transport_Homo sapiens_hsa030132.19376287
15Homologous recombination_Homo sapiens_hsa034402.13374808
16Oxidative phosphorylation_Homo sapiens_hsa001901.98674439
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98052006
18Butanoate metabolism_Homo sapiens_hsa006501.93831286
19mRNA surveillance pathway_Homo sapiens_hsa030151.91384789
20Non-homologous end-joining_Homo sapiens_hsa034501.89944872
21Base excision repair_Homo sapiens_hsa034101.85981911
22RNA degradation_Homo sapiens_hsa030181.84823769
23Oocyte meiosis_Homo sapiens_hsa041141.78776718
24Parkinsons disease_Homo sapiens_hsa050121.72463764
25Phototransduction_Homo sapiens_hsa047441.72062319
26Purine metabolism_Homo sapiens_hsa002301.65604854
27Pyrimidine metabolism_Homo sapiens_hsa002401.60797198
28Selenocompound metabolism_Homo sapiens_hsa004501.58100582
29Peroxisome_Homo sapiens_hsa041461.52187784
30Fatty acid elongation_Homo sapiens_hsa000621.50525419
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49667837
32Caffeine metabolism_Homo sapiens_hsa002321.47457614
33Hedgehog signaling pathway_Homo sapiens_hsa043401.44755546
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44745134
35Amphetamine addiction_Homo sapiens_hsa050311.42411006
36Nicotine addiction_Homo sapiens_hsa050331.36869975
37Nitrogen metabolism_Homo sapiens_hsa009101.36429993
38Alzheimers disease_Homo sapiens_hsa050101.35403022
39Steroid biosynthesis_Homo sapiens_hsa001001.34855897
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.32037835
41Olfactory transduction_Homo sapiens_hsa047401.30397721
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26287134
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23658901
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22201060
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.21743960
46Chemical carcinogenesis_Homo sapiens_hsa052041.19513795
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17327677
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16923956
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15795372
50Vibrio cholerae infection_Homo sapiens_hsa051101.14509655
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.13995709
52Tryptophan metabolism_Homo sapiens_hsa003801.13975701
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11568174
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08623137
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.05815389
56Basal cell carcinoma_Homo sapiens_hsa052171.04854922
57Alcoholism_Homo sapiens_hsa050341.04819741
58Collecting duct acid secretion_Homo sapiens_hsa049661.04656943
59Taste transduction_Homo sapiens_hsa047421.04020754
60beta-Alanine metabolism_Homo sapiens_hsa004101.02133534
61SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00976402
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00141210
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99307836
64One carbon pool by folate_Homo sapiens_hsa006700.98532604
65Dopaminergic synapse_Homo sapiens_hsa047280.96243638
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96075661
67Retinol metabolism_Homo sapiens_hsa008300.95877158
68Circadian entrainment_Homo sapiens_hsa047130.94282150
69Long-term potentiation_Homo sapiens_hsa047200.93124870
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92388217
71TGF-beta signaling pathway_Homo sapiens_hsa043500.91902517
72Fatty acid degradation_Homo sapiens_hsa000710.91615726
73Wnt signaling pathway_Homo sapiens_hsa043100.91346954
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89943463
75Hippo signaling pathway_Homo sapiens_hsa043900.89493592
76Ribosome_Homo sapiens_hsa030100.88811964
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88402114
78Insulin secretion_Homo sapiens_hsa049110.87014350
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86795457
80Glutathione metabolism_Homo sapiens_hsa004800.86739332
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83371443
82Synaptic vesicle cycle_Homo sapiens_hsa047210.83073014
83Serotonergic synapse_Homo sapiens_hsa047260.81498046
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77935069
85N-Glycan biosynthesis_Homo sapiens_hsa005100.77597242
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77455616
87Regulation of autophagy_Homo sapiens_hsa041400.75739298
88Metabolic pathways_Homo sapiens_hsa011000.75622162
89Fatty acid metabolism_Homo sapiens_hsa012120.72924949
90Pyruvate metabolism_Homo sapiens_hsa006200.70840301
91Arachidonic acid metabolism_Homo sapiens_hsa005900.70357947
92Epstein-Barr virus infection_Homo sapiens_hsa051690.70085873
93Folate biosynthesis_Homo sapiens_hsa007900.69516226
94Renin secretion_Homo sapiens_hsa049240.68484160
95Cocaine addiction_Homo sapiens_hsa050300.68143661
96Glucagon signaling pathway_Homo sapiens_hsa049220.67904869
97Melanogenesis_Homo sapiens_hsa049160.65880184
98Sulfur metabolism_Homo sapiens_hsa009200.64401579
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63269377
100Systemic lupus erythematosus_Homo sapiens_hsa053220.61619178
101Morphine addiction_Homo sapiens_hsa050320.61605438
102GABAergic synapse_Homo sapiens_hsa047270.61324395
103Cardiac muscle contraction_Homo sapiens_hsa042600.60706418
104Glutamatergic synapse_Homo sapiens_hsa047240.55230273
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54434234
106Axon guidance_Homo sapiens_hsa043600.54178342
107Dorso-ventral axis formation_Homo sapiens_hsa043200.53612209
108Thyroid hormone synthesis_Homo sapiens_hsa049180.52654317
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50927369
110Ether lipid metabolism_Homo sapiens_hsa005650.50004546
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49592007
112p53 signaling pathway_Homo sapiens_hsa041150.48841246
113Calcium signaling pathway_Homo sapiens_hsa040200.48727990
114Ovarian steroidogenesis_Homo sapiens_hsa049130.48398715
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47875578
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47359989
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45870903
118Long-term depression_Homo sapiens_hsa047300.44441627
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43270255
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42874618
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42046731
122Melanoma_Homo sapiens_hsa052180.41103653
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40773391
124Viral carcinogenesis_Homo sapiens_hsa052030.39661365
125Tight junction_Homo sapiens_hsa045300.38751991
126Linoleic acid metabolism_Homo sapiens_hsa005910.38620399
127Arginine and proline metabolism_Homo sapiens_hsa003300.38427352
128Circadian rhythm_Homo sapiens_hsa047100.35046339
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34610090
130Vitamin B6 metabolism_Homo sapiens_hsa007500.34531969
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33704806
132Carbon metabolism_Homo sapiens_hsa012000.33630401
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.33377997
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32117794
135Gap junction_Homo sapiens_hsa045400.31638719
136HTLV-I infection_Homo sapiens_hsa051660.31630077
137Prostate cancer_Homo sapiens_hsa052150.31556800
138Fat digestion and absorption_Homo sapiens_hsa049750.31501244
139Tyrosine metabolism_Homo sapiens_hsa003500.30226534
140Estrogen signaling pathway_Homo sapiens_hsa049150.30215459
141Thyroid cancer_Homo sapiens_hsa052160.29786899
142Pathways in cancer_Homo sapiens_hsa052000.26755636
143Histidine metabolism_Homo sapiens_hsa003400.24808397
144Starch and sucrose metabolism_Homo sapiens_hsa005000.23947608

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »