IFT80

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of the intraflagellar transport complex B and is necessary for the function of motile and sensory cilia. Defects in this gene are a cause of asphyxiating thoracic dystrophy 2 (ATD2). Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.39821975
2cilium or flagellum-dependent cell motility (GO:0001539)5.52552235
3regulation of cilium movement (GO:0003352)4.40789606
4axonemal dynein complex assembly (GO:0070286)4.33967564
5superoxide anion generation (GO:0042554)4.24233210
6centriole assembly (GO:0098534)4.11740059
7motile cilium assembly (GO:0044458)4.06449107
8left/right pattern formation (GO:0060972)4.03155492
9poly(A)+ mRNA export from nucleus (GO:0016973)3.93238569
10G-protein coupled receptor internalization (GO:0002031)3.88578081
11plasma membrane fusion (GO:0045026)3.86443173
12neural tube formation (GO:0001841)3.85352440
13cilium morphogenesis (GO:0060271)3.81308713
14cilium movement (GO:0003341)3.76070517
15* cellular component assembly involved in morphogenesis (GO:0010927)3.42042917
16left/right axis specification (GO:0070986)3.40602051
17regulation of DNA endoreduplication (GO:0032875)3.32814956
18centriole replication (GO:0007099)3.31143657
19peptidyl-threonine dephosphorylation (GO:0035970)3.29953215
20meiotic chromosome segregation (GO:0045132)3.24564247
21microtubule bundle formation (GO:0001578)3.23573889
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.19864677
23histone H3-K4 trimethylation (GO:0080182)3.17460055
24piRNA metabolic process (GO:0034587)3.14386787
25phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.11415846
26DNA methylation involved in gamete generation (GO:0043046)3.06247589
27cytoplasmic mRNA processing body assembly (GO:0033962)3.05193971
28kinetochore organization (GO:0051383)2.99643939
29lateral sprouting from an epithelium (GO:0060601)2.99099744
30mesenchymal cell differentiation involved in renal system development (GO:2001012)2.95015672
31mesenchymal cell differentiation involved in kidney development (GO:0072161)2.95015672
32histone H3-K36 demethylation (GO:0070544)2.93881684
33rRNA catabolic process (GO:0016075)2.92375765
34regulation of timing of cell differentiation (GO:0048505)2.90583619
35somite development (GO:0061053)2.89737831
36retinal cone cell development (GO:0046549)2.87752069
37kinetochore assembly (GO:0051382)2.87236874
38epithelial cilium movement (GO:0003351)2.85202717
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.84193336
40DNA synthesis involved in DNA repair (GO:0000731)2.81200008
41regulation of meiosis I (GO:0060631)2.81180065
42negative regulation of cytosolic calcium ion concentration (GO:0051481)2.80639350
43inner ear receptor stereocilium organization (GO:0060122)2.79961348
44ventricular system development (GO:0021591)2.79907949
45energy homeostasis (GO:0097009)2.78708252
46regulation of centriole replication (GO:0046599)2.76735704
47* cell projection assembly (GO:0030031)2.75578521
48embryonic epithelial tube formation (GO:0001838)2.74392670
49microtubule-based movement (GO:0007018)2.74067737
50protein localization to cilium (GO:0061512)2.73651166
51female gonad development (GO:0008585)2.73247908
52positive regulation of uterine smooth muscle contraction (GO:0070474)2.72888573
53microtubule depolymerization (GO:0007019)2.72813934
54auditory receptor cell stereocilium organization (GO:0060088)2.72279741
55V(D)J recombination (GO:0033151)2.71923416
56DNA strand renaturation (GO:0000733)2.70318909
57positive regulation of receptor recycling (GO:0001921)2.69690948
58photoreceptor cell maintenance (GO:0045494)2.68715996
59determination of left/right symmetry (GO:0007368)2.68661126
60axoneme assembly (GO:0035082)2.67610875
61replicative senescence (GO:0090399)2.65945207
62microtubule polymerization or depolymerization (GO:0031109)2.65750667
63positive regulation of meiosis (GO:0045836)2.65423394
64regulation of development, heterochronic (GO:0040034)2.63670714
65negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.62643737
66negative regulation of translation, ncRNA-mediated (GO:0040033)2.62643737
67regulation of translation, ncRNA-mediated (GO:0045974)2.62643737
68determination of bilateral symmetry (GO:0009855)2.61964231
69negative regulation of synaptic transmission, GABAergic (GO:0032229)2.61879248
70regulation of hippo signaling (GO:0035330)2.61303408
71male sex determination (GO:0030238)2.60635222
72DNA integration (GO:0015074)2.59963488
73epithelial tube formation (GO:0072175)2.59444846
74* cilium assembly (GO:0042384)2.59152915
75C4-dicarboxylate transport (GO:0015740)2.58952911
76regulation of microtubule-based movement (GO:0060632)2.58763434
77righting reflex (GO:0060013)2.58111448
78* cilium organization (GO:0044782)2.57565491
79modulation by virus of host process (GO:0019054)2.56341528
80preassembly of GPI anchor in ER membrane (GO:0016254)2.55815072
81keratinocyte development (GO:0003334)2.55652729
82relaxation of cardiac muscle (GO:0055119)2.55452817
83male meiosis (GO:0007140)2.55038787
84response to X-ray (GO:0010165)2.53162197
85specification of symmetry (GO:0009799)2.53126577
86termination of G-protein coupled receptor signaling pathway (GO:0038032)2.51650733
87ganglion development (GO:0061548)2.51079137
88positive regulation of CREB transcription factor activity (GO:0032793)2.50662986
89hematopoietic stem cell proliferation (GO:0071425)2.50026749
90startle response (GO:0001964)2.49557842
91intraciliary transport (GO:0042073)2.49440013
92cell proliferation in forebrain (GO:0021846)2.49157850
93organelle disassembly (GO:1903008)2.47700699
94prenylation (GO:0097354)2.47453746
95protein prenylation (GO:0018342)2.47453746
96synapsis (GO:0007129)2.47076044
97detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.46945414
98interkinetic nuclear migration (GO:0022027)2.44753125
99positive regulation of interleukin-1 beta secretion (GO:0050718)2.44708704
100negative regulation of T cell mediated immunity (GO:0002710)2.44645329
101reflex (GO:0060004)2.43791876
102interferon-gamma production (GO:0032609)2.42961333
103negative regulation of keratinocyte proliferation (GO:0010839)2.41251151
104positive regulation of meiotic cell cycle (GO:0051446)2.39719919
105cellular response to gamma radiation (GO:0071480)2.38675721
106pyrimidine nucleobase catabolic process (GO:0006208)2.38531031
107reciprocal DNA recombination (GO:0035825)2.37607107
108reciprocal meiotic recombination (GO:0007131)2.37607107
109negative regulation of astrocyte differentiation (GO:0048712)2.34328720
110photoreceptor cell differentiation (GO:0046530)2.33974862
111eye photoreceptor cell differentiation (GO:0001754)2.33974862
112presynaptic membrane assembly (GO:0097105)2.33876562
113extracellular negative regulation of signal transduction (GO:1900116)2.33795202
114extracellular regulation of signal transduction (GO:1900115)2.33795202
115microtubule anchoring (GO:0034453)2.33540196
116lateral ventricle development (GO:0021670)2.30878998
117head development (GO:0060322)2.29341035
118photoreceptor cell development (GO:0042461)2.29167985
119negative regulation of DNA recombination (GO:0045910)2.28738959
120positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.28398894
121retina layer formation (GO:0010842)2.28308137
122retinal ganglion cell axon guidance (GO:0031290)2.27932815
123negative regulation of osteoblast proliferation (GO:0033689)2.27807601
124negative regulation of mast cell activation (GO:0033004)2.27802941
125water-soluble vitamin biosynthetic process (GO:0042364)2.27138890
126limb bud formation (GO:0060174)2.26744899
127superoxide metabolic process (GO:0006801)2.26730132
128nonmotile primary cilium assembly (GO:0035058)2.26417118
129negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.26312779
130cellular response to interleukin-15 (GO:0071350)2.25942360
131mesenchymal cell differentiation (GO:0048762)2.25579878
132inositol metabolic process (GO:0006020)2.25371840
133somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.25218895
134isotype switching (GO:0045190)2.25218895
135somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.25218895
136regulation of mesoderm development (GO:2000380)2.25200251
137pituitary gland development (GO:0021983)2.24961801
138regulation of pigment cell differentiation (GO:0050932)2.24786636
139lipid particle organization (GO:0034389)2.24659077
140L-fucose catabolic process (GO:0042355)2.24586526
141fucose catabolic process (GO:0019317)2.24586526
142L-fucose metabolic process (GO:0042354)2.24586526
143resolution of meiotic recombination intermediates (GO:0000712)2.24555383
144aldehyde catabolic process (GO:0046185)2.23521254
145negative regulation of axon guidance (GO:1902668)2.23243848
146sex determination (GO:0007530)2.22984505
147male meiosis I (GO:0007141)2.22604215
148centrosome duplication (GO:0051298)2.22227913
149protein import into peroxisome matrix (GO:0016558)2.22025059
150cranial nerve structural organization (GO:0021604)2.22024724
151regulation of centrosome duplication (GO:0010824)2.21463790
152nucleus localization (GO:0051647)2.21412988
153modulation by symbiont of host cellular process (GO:0044068)2.21370025
154peptidyl-lysine trimethylation (GO:0018023)2.20301710
155positive regulation of interleukin-1 secretion (GO:0050716)2.19408845
156sequestering of extracellular ligand from receptor (GO:0035581)2.19212956
157regulation of regulatory T cell differentiation (GO:0045589)2.19039439
158positive regulation of cellular amide metabolic process (GO:0034250)2.18970359
159termination of signal transduction (GO:0023021)2.17138040
160limb development (GO:0060173)2.16076770
161appendage development (GO:0048736)2.16076770
162* smoothened signaling pathway (GO:0007224)2.15089522
163multicellular organism reproduction (GO:0032504)2.15021656
164DNA ligation (GO:0006266)2.13385226
165spinal cord motor neuron differentiation (GO:0021522)2.12563885
166intra-S DNA damage checkpoint (GO:0031573)2.11219111
167regulation of keratinocyte proliferation (GO:0010837)2.08697251
168L-amino acid import (GO:0043092)2.08498826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.65847586
2EZH2_22144423_ChIP-Seq_EOC_Human3.17147189
3PCGF2_27294783_Chip-Seq_ESCs_Mouse2.86076421
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.76280134
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.61202118
6PCGF2_27294783_Chip-Seq_NPCs_Mouse2.53487807
7SUZ12_27294783_Chip-Seq_NPCs_Mouse2.46595911
8NFE2_27457419_Chip-Seq_LIVER_Mouse2.36573637
9VDR_22108803_ChIP-Seq_LS180_Human2.21786655
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18864372
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12311640
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.11974663
13EZH2_27294783_Chip-Seq_NPCs_Mouse2.11353677
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09387215
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05919939
16TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse2.05219569
17ZNF274_21170338_ChIP-Seq_K562_Hela2.02183667
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01880456
19NANOG_18555785_Chip-Seq_ESCs_Mouse2.01727386
20IGF1R_20145208_ChIP-Seq_DFB_Human1.99406692
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98275148
22E2F1_18555785_Chip-Seq_ESCs_Mouse1.97272166
23* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.96812780
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93818811
25* P53_22387025_ChIP-Seq_ESCs_Mouse1.88191035
26* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.85546757
27STAT3_18555785_Chip-Seq_ESCs_Mouse1.83043287
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.82461087
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81613914
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.81256877
31EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.79599790
32CMYC_18555785_Chip-Seq_ESCs_Mouse1.79024977
33NMYC_18555785_Chip-Seq_ESCs_Mouse1.78578322
34P300_18555785_Chip-Seq_ESCs_Mouse1.73280425
35OCT4_18555785_Chip-Seq_ESCs_Mouse1.70774049
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68885077
37P300_19829295_ChIP-Seq_ESCs_Human1.68771927
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65016267
39FUS_26573619_Chip-Seq_HEK293_Human1.64662157
40SOX2_18555785_Chip-Seq_ESCs_Mouse1.62417668
41RUNX1_27457419_Chip-Seq_LIVER_Mouse1.61937387
42CBP_20019798_ChIP-Seq_JUKART_Human1.61886021
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61886021
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.60742369
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60563521
46TAF15_26573619_Chip-Seq_HEK293_Human1.60080955
47SMAD4_21799915_ChIP-Seq_A2780_Human1.59776283
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59237957
49TP53_16413492_ChIP-PET_HCT116_Human1.59219403
50ZFX_18555785_Chip-Seq_ESCs_Mouse1.58342631
51STAT3_23295773_ChIP-Seq_U87_Human1.57672604
52* PU1_27457419_Chip-Seq_LIVER_Mouse1.57034366
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.56881888
54KLF4_18555785_Chip-Seq_ESCs_Mouse1.55588318
55ESRRB_18555785_Chip-Seq_ESCs_Mouse1.55390418
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.53578412
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.53032105
58OCT4_21477851_ChIP-Seq_ESCs_Mouse1.51431131
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51361934
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51094797
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50638380
62RNF2_27304074_Chip-Seq_NSC_Mouse1.49049440
63CTCF_18555785_Chip-Seq_ESCs_Mouse1.48707788
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48301087
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48301087
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47225858
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.46870506
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46382617
69AR_25329375_ChIP-Seq_VCAP_Human1.46363985
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44941461
71TCF4_22108803_ChIP-Seq_LS180_Human1.42921619
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42580665
73SMAD1_18555785_Chip-Seq_ESCs_Mouse1.42277698
74EWS_26573619_Chip-Seq_HEK293_Human1.41536696
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41201723
76* FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40274296
77TCF4_23295773_ChIP-Seq_U87_Human1.38731192
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37790014
79DROSHA_22980978_ChIP-Seq_HELA_Human1.37344313
80EZH2_27304074_Chip-Seq_ESCs_Mouse1.37241189
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35536395
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.35447336
83ER_23166858_ChIP-Seq_MCF-7_Human1.33469374
84* TAL1_26923725_Chip-Seq_HPCs_Mouse1.33265781
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.32570940
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32502336
87BCAT_22108803_ChIP-Seq_LS180_Human1.31244915
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30918392
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30177956
90KDM2B_26808549_Chip-Seq_REH_Human1.28521122
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28276618
92SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27807715
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27687598
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26590862
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.24870660
96* SMAD3_21741376_ChIP-Seq_EPCs_Human1.24499607
97RNF2_27304074_Chip-Seq_ESCs_Mouse1.23915931
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23581825
99AR_21572438_ChIP-Seq_LNCaP_Human1.23525359
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23085767
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21139263
102TP53_18474530_ChIP-ChIP_U2OS_Human1.20276474
103* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19689083
104NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19312670
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19312670
106LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18968113
107ELK1_19687146_ChIP-ChIP_HELA_Human1.18656489
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18486956
109IRF1_19129219_ChIP-ChIP_H3396_Human1.18433456
110EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18364672
111RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18364672
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16799422
113RUNX2_22187159_ChIP-Seq_PCA_Human1.15842227
114TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.15733903
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15702087
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14610505
117JUN_21703547_ChIP-Seq_K562_Human1.14411541
118ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14214357
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.13827115
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13177481
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12324612
122EZH2_27294783_Chip-Seq_ESCs_Mouse1.12151068
123AHR_22903824_ChIP-Seq_MCF-7_Human1.11989879
124SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11089483
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10565617
126JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09924493
127STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08299406
128TBL1_22424771_ChIP-Seq_293T_Human1.08018496
129PRDM14_20953172_ChIP-Seq_ESCs_Human1.07872069
130SOX2_21211035_ChIP-Seq_LN229_Gbm1.07611193
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07089784
132* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06338497
133IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05837484
134CDX2_22108803_ChIP-Seq_LS180_Human1.05427347
135* SMAD4_21741376_ChIP-Seq_EPCs_Human1.05038141
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04209594
137NANOG_19829295_ChIP-Seq_ESCs_Human1.04107304
138SOX2_19829295_ChIP-Seq_ESCs_Human1.04107304
139MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03523216
140KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03306393
141STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02099883
142MYC_18940864_ChIP-ChIP_HL60_Human1.01583178
143* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01511475

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.00605141
2MP0000569_abnormal_digit_pigmentation3.58690706
3MP0003136_yellow_coat_color3.32582111
4MP0003787_abnormal_imprinting3.15982125
5MP0002102_abnormal_ear_morphology2.97932950
6MP0006292_abnormal_olfactory_placode2.77048360
7MP0000566_synostosis2.69723575
8MP0005409_darkened_coat_color2.58978190
9MP0003122_maternal_imprinting2.49763853
10MP0008877_abnormal_DNA_methylation2.45096799
11MP0004381_abnormal_hair_follicle2.25489078
12MP0005174_abnormal_tail_pigmentation2.12924856
13MP0000015_abnormal_ear_pigmentation2.08482017
14MP0008058_abnormal_DNA_repair2.06483452
15MP0004885_abnormal_endolymph2.02797720
16MP0001986_abnormal_taste_sensitivity2.01786575
17MP0002277_abnormal_respiratory_mucosa1.99144026
18MP0009780_abnormal_chondrocyte_physiolo1.89057074
19MP0003890_abnormal_embryonic-extraembry1.88301608
20MP0005645_abnormal_hypothalamus_physiol1.86261849
21MP0005171_absent_coat_pigmentation1.85869123
22MP0004147_increased_porphyrin_level1.83811860
23MP0004742_abnormal_vestibular_system1.80202527
24MP0003941_abnormal_skin_development1.78072303
25MP0001486_abnormal_startle_reflex1.71983154
26MP0000383_abnormal_hair_follicle1.70937139
27MP0002735_abnormal_chemical_nociception1.66913099
28MP0005551_abnormal_eye_electrophysiolog1.66529446
29MP0003045_fibrosis1.61707387
30MP0002272_abnormal_nervous_system1.58597083
31MP0001984_abnormal_olfaction1.57521704
32MP0004133_heterotaxia1.57173546
33MP0001485_abnormal_pinna_reflex1.44157780
34MP0004043_abnormal_pH_regulation1.43621156
35MP0001346_abnormal_lacrimal_gland1.40647118
36MP0005646_abnormal_pituitary_gland1.38924736
37MP0005253_abnormal_eye_physiology1.38454399
38MP0001293_anophthalmia1.37497857
39MP0002009_preneoplasia1.36283834
40MP0002734_abnormal_mechanical_nocicepti1.36075012
41MP0005410_abnormal_fertilization1.34209538
42MP0008004_abnormal_stomach_pH1.32670049
43MP0002938_white_spotting1.32524722
44MP0008057_abnormal_DNA_replication1.31058247
45MP0006072_abnormal_retinal_apoptosis1.30834112
46MP0005187_abnormal_penis_morphology1.30385968
47MP0002653_abnormal_ependyma_morphology1.30383927
48MP0003763_abnormal_thymus_physiology1.30266021
49MP0000026_abnormal_inner_ear1.29493493
50MP0002234_abnormal_pharynx_morphology1.28056222
51MP0008995_early_reproductive_senescence1.26359639
52MP0002095_abnormal_skin_pigmentation1.25806658
53MP0001299_abnormal_eye_distance/1.25139707
54MP0000955_abnormal_spinal_cord1.24667654
55MP0009745_abnormal_behavioral_response1.24006989
56MP0000579_abnormal_nail_morphology1.21761412
57MP0008789_abnormal_olfactory_epithelium1.19822367
58MP0008875_abnormal_xenobiotic_pharmacok1.17838311
59MP0002928_abnormal_bile_duct1.16261685
60MP0001177_atelectasis1.14651512
61MP0001502_abnormal_circadian_rhythm1.14207504
62MP0002638_abnormal_pupillary_reflex1.13384094
63MP0009046_muscle_twitch1.12887863
64MP0003635_abnormal_synaptic_transmissio1.12692261
65MP0003283_abnormal_digestive_organ1.12444979
66MP0001963_abnormal_hearing_physiology1.12076113
67MP0002282_abnormal_trachea_morphology1.10693675
68MP0001501_abnormal_sleep_pattern1.08974905
69MP0010094_abnormal_chromosome_stability1.07272887
70MP0004859_abnormal_synaptic_plasticity1.06527002
71MP0005075_abnormal_melanosome_morpholog1.06167603
72MP0001968_abnormal_touch/_nociception1.05499554
73MP0005248_abnormal_Harderian_gland1.05341137
74MP0003698_abnormal_male_reproductive1.05261007
75MP0000428_abnormal_craniofacial_morphol1.05027709
76MP0003121_genomic_imprinting1.04821760
77MP0006276_abnormal_autonomic_nervous1.04057241
78MP0002210_abnormal_sex_determination1.01846673
79MP0002876_abnormal_thyroid_physiology1.00817966
80MP0002751_abnormal_autonomic_nervous1.00402326
81MP0010386_abnormal_urinary_bladder1.00048842
82MP0003755_abnormal_palate_morphology0.99821889
83MP0002736_abnormal_nociception_after0.98363981
84MP0002064_seizures0.98311447
85MP0002572_abnormal_emotion/affect_behav0.96812720
86MP0002932_abnormal_joint_morphology0.95623700
87MP0002063_abnormal_learning/memory/cond0.94816149
88MP0002067_abnormal_sensory_capabilities0.93660335
89MP0003011_delayed_dark_adaptation0.91064296
90MP0002752_abnormal_somatic_nervous0.90673013
91MP0004924_abnormal_behavior0.90051327
92MP0005386_behavior/neurological_phenoty0.90051327
93MP0000490_abnormal_crypts_of0.89588454
94MP0002177_abnormal_outer_ear0.89350529
95MP0002909_abnormal_adrenal_gland0.89271215
96MP0003119_abnormal_digestive_system0.89254265
97MP0003195_calcinosis0.89130978
98MP0005257_abnormal_intraocular_pressure0.89113093
99MP0003252_abnormal_bile_duct0.88693447
100MP0002557_abnormal_social/conspecific_i0.88595252
101MP0002160_abnormal_reproductive_system0.87366803
102MP0006054_spinal_hemorrhage0.87218013
103MP0002233_abnormal_nose_morphology0.86339356
104MP0002396_abnormal_hematopoietic_system0.84934744
105MP0001929_abnormal_gametogenesis0.84634883
106MP0003950_abnormal_plasma_membrane0.84243544
107MP0001286_abnormal_eye_development0.84152045
108MP0004215_abnormal_myocardial_fiber0.84113800
109MP0002249_abnormal_larynx_morphology0.82662684
110MP0000427_abnormal_hair_cycle0.82499232
111MP0001873_stomach_inflammation0.82368048
112MP0001970_abnormal_pain_threshold0.82241963
113MP0002184_abnormal_innervation0.81840075
114MP0003938_abnormal_ear_development0.81664279
115MP0000639_abnormal_adrenal_gland0.81295954
116MP0005379_endocrine/exocrine_gland_phen0.81146148
117MP0004270_analgesia0.80836548
118MP0000013_abnormal_adipose_tissue0.80824801
119MP0003937_abnormal_limbs/digits/tail_de0.80732391
120MP0003111_abnormal_nucleus_morphology0.80351318
121MP0000372_irregular_coat_pigmentation0.80206260
122MP0009250_abnormal_appendicular_skeleto0.80163222
123MP0005647_abnormal_sex_gland0.79642531
124MP0005195_abnormal_posterior_eye0.79519328
125MP0005451_abnormal_body_composition0.79048444
126MP0005391_vision/eye_phenotype0.78978921
127MP0000647_abnormal_sebaceous_gland0.78225105
128MP0002882_abnormal_neuron_morphology0.78169062
129MP0000049_abnormal_middle_ear0.76995614
130MP0009697_abnormal_copulation0.76781410
131MP0004134_abnormal_chest_morphology0.75909935
132MP0005503_abnormal_tendon_morphology0.75574987
133MP0002109_abnormal_limb_morphology0.75446470
134MP0000470_abnormal_stomach_morphology0.75243159
135MP0000778_abnormal_nervous_system0.74797117
136MP0004484_altered_response_of0.73337032
137MP0005671_abnormal_response_to0.72495328
138MP0001790_abnormal_immune_system0.72413037
139MP0005387_immune_system_phenotype0.72413037
140MP0005389_reproductive_system_phenotype0.72113453
141MP0005423_abnormal_somatic_nervous0.71760051
142MP0002163_abnormal_gland_morphology0.71614385
143MP0001186_pigmentation_phenotype0.71067757
144MP0009384_cardiac_valve_regurgitation0.70800708
145MP0003880_abnormal_central_pattern0.69212330
146MP0001119_abnormal_female_reproductive0.68462834
147MP0000631_abnormal_neuroendocrine_gland0.68007628
148MP0001270_distended_abdomen0.67408127
149MP0010678_abnormal_skin_adnexa0.66649914
150MP0004142_abnormal_muscle_tone0.66534773
151MP0009764_decreased_sensitivity_to0.66475270

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.39580473
2Chromsome breakage (HP:0040012)4.98076201
3Abnormal ciliary motility (HP:0012262)4.89149184
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.77837324
5Abnormal respiratory motile cilium physiology (HP:0012261)4.45564510
6Absent/shortened dynein arms (HP:0200106)4.40692279
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.40692279
8Febrile seizures (HP:0002373)3.64717876
9Abnormal respiratory epithelium morphology (HP:0012253)3.59805169
10Abnormal respiratory motile cilium morphology (HP:0005938)3.59805169
11Gait imbalance (HP:0002141)3.44239550
12Chronic bronchitis (HP:0004469)3.41807068
13Tubulointerstitial nephritis (HP:0001970)3.40721218
14Cystic liver disease (HP:0006706)3.36125092
15Duplicated collecting system (HP:0000081)3.20684519
16Genital tract atresia (HP:0001827)3.02744914
17Prostate neoplasm (HP:0100787)3.02693015
18Vaginal atresia (HP:0000148)2.99966523
19Abnormality of the renal collecting system (HP:0004742)2.92051314
20Congenital stationary night blindness (HP:0007642)2.85324020
21Nephronophthisis (HP:0000090)2.82167862
22Upper limb muscle weakness (HP:0003484)2.78903168
23Sex reversal (HP:0012245)2.64997904
24Abnormal sex determination (HP:0012244)2.64997904
25Rhinitis (HP:0012384)2.62978197
26Abnormality of the renal medulla (HP:0100957)2.62862293
27* Postaxial hand polydactyly (HP:0001162)2.50977537
28Poor coordination (HP:0002370)2.49881095
29Ectopic kidney (HP:0000086)2.49035725
30Abnormality of the nasal septum (HP:0000419)2.45451402
31Decreased central vision (HP:0007663)2.45365863
32Tubular atrophy (HP:0000092)2.43490560
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.39624347
34Anal stenosis (HP:0002025)2.39486966
35Abnormality of DNA repair (HP:0003254)2.37130488
36Bronchiectasis (HP:0002110)2.36691710
37Chronic hepatic failure (HP:0100626)2.35496809
38Arthropathy (HP:0003040)2.33013931
39Aplasia/Hypoplasia of the spleen (HP:0010451)2.25896843
40Septo-optic dysplasia (HP:0100842)2.24632555
41Abnormality of the preputium (HP:0100587)2.24212498
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23194004
43True hermaphroditism (HP:0010459)2.22592331
44Asplenia (HP:0001746)2.21646558
45Meckel diverticulum (HP:0002245)2.21166201
46Chronic sinusitis (HP:0011109)2.20226139
47Abnormality of chromosome stability (HP:0003220)2.19910222
48Abnormality of incisor morphology (HP:0011063)2.19001163
49Attenuation of retinal blood vessels (HP:0007843)2.17796161
50Dyschromatopsia (HP:0007641)2.14134200
51Lip pit (HP:0100267)2.13605629
52Aplasia cutis congenita (HP:0001057)2.12138752
53Adrenal hypoplasia (HP:0000835)2.10384325
54Volvulus (HP:0002580)2.09256425
55Abnormality of the ileum (HP:0001549)2.07154333
56Stomach cancer (HP:0012126)2.06056416
57Focal motor seizures (HP:0011153)2.04968509
58Congenital sensorineural hearing impairment (HP:0008527)2.04909957
59Oligodactyly (hands) (HP:0001180)2.03753794
60Renal salt wasting (HP:0000127)2.02327019
61Clubbing of toes (HP:0100760)2.01689682
62Bony spicule pigmentary retinopathy (HP:0007737)2.01222750
63Papillary thyroid carcinoma (HP:0002895)2.01016923
64* Short foot (HP:0001773)1.99941375
65Pancreatic fibrosis (HP:0100732)1.98571917
66Spinal muscular atrophy (HP:0007269)1.98451264
67Broad foot (HP:0001769)1.98265694
68Colon cancer (HP:0003003)1.98238431
69White forelock (HP:0002211)1.98075670
70Male pseudohermaphroditism (HP:0000037)1.97318448
71Medial flaring of the eyebrow (HP:0010747)1.96356696
72Renal cortical cysts (HP:0000803)1.94476161
73Duplication of thumb phalanx (HP:0009942)1.93616615
74Focal seizures (HP:0007359)1.92838229
75Abnormality of the renal cortex (HP:0011035)1.92198960
76* Postaxial foot polydactyly (HP:0001830)1.90467220
77Glioma (HP:0009733)1.89953502
78Type II lissencephaly (HP:0007260)1.87041777
79Abnormality of the carotid arteries (HP:0005344)1.86204462
80Bronchitis (HP:0012387)1.85826606
81Recurrent sinusitis (HP:0011108)1.85195824
82Molar tooth sign on MRI (HP:0002419)1.83671896
83Abnormality of midbrain morphology (HP:0002418)1.83671896
84Nephroblastoma (Wilms tumor) (HP:0002667)1.83615061
85Fair hair (HP:0002286)1.83582197
86Aplasia/Hypoplasia of the tibia (HP:0005772)1.83179904
87Widely spaced teeth (HP:0000687)1.82533328
88Specific learning disability (HP:0001328)1.82374522
89Abnormality of the fingertips (HP:0001211)1.81710028
90Midline defect of the nose (HP:0004122)1.81541857
91Small hand (HP:0200055)1.80325556
92Neonatal respiratory distress (HP:0002643)1.80042201
93Wrist flexion contracture (HP:0001239)1.79411075
94Abnormality of macular pigmentation (HP:0008002)1.79382828
95Anencephaly (HP:0002323)1.76753608
96Cutaneous finger syndactyly (HP:0010554)1.76727332
97Progressive inability to walk (HP:0002505)1.76652086
98Abnormal rod and cone electroretinograms (HP:0008323)1.74944918
99Bifid tongue (HP:0010297)1.73885024
100Optic nerve hypoplasia (HP:0000609)1.73165584
101Abnormality of the astrocytes (HP:0100707)1.73035612
102Astrocytoma (HP:0009592)1.73035612
103Patchy hypopigmentation of hair (HP:0011365)1.72876060
104Sclerocornea (HP:0000647)1.72768584
105Oculomotor apraxia (HP:0000657)1.72411346
106Absent speech (HP:0001344)1.72345587
107Abolished electroretinogram (ERG) (HP:0000550)1.72164572
108Generalized hypopigmentation of hair (HP:0011358)1.72122661
109Stage 5 chronic kidney disease (HP:0003774)1.71473483
110Increased corneal curvature (HP:0100692)1.70090315
111Keratoconus (HP:0000563)1.70090315
112Abnormality of molar (HP:0011077)1.69277098
113Abnormality of molar morphology (HP:0011070)1.69277098
114Gaze-evoked nystagmus (HP:0000640)1.68577695
115Embryonal renal neoplasm (HP:0011794)1.67377792
116Aplasia/Hypoplasia of the tongue (HP:0010295)1.66984347
117Infertility (HP:0000789)1.66978639
118Abnormality of the incisor (HP:0000676)1.65202996
119Narrow forehead (HP:0000341)1.64799008
120Astigmatism (HP:0000483)1.63272562
121Anal atresia (HP:0002023)1.63120377
122Thyroiditis (HP:0100646)1.61961918
123Thyroid-stimulating hormone excess (HP:0002925)1.61569587
124Retrobulbar optic neuritis (HP:0100654)1.61387965
125Optic neuritis (HP:0100653)1.61387965
126Rhabdomyosarcoma (HP:0002859)1.61371967
127* Preaxial hand polydactyly (HP:0001177)1.60841311
128Pancreatic cysts (HP:0001737)1.60607863
129Medulloblastoma (HP:0002885)1.60205718
130Bile duct proliferation (HP:0001408)1.59459586
131Abnormal biliary tract physiology (HP:0012439)1.59459586
132* Congenital hepatic fibrosis (HP:0002612)1.59133726
133Alveolar cell carcinoma (HP:0006519)1.58964689
134Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.58898115
135Degeneration of the lateral corticospinal tracts (HP:0002314)1.58898115
136Abnormality of the middle phalanges of the toes (HP:0010183)1.58009067
137Drooling (HP:0002307)1.57805709
138Decreased testicular size (HP:0008734)1.57212271
139Absent frontal sinuses (HP:0002688)1.56555979
140Hyperventilation (HP:0002883)1.56404029
141Tubulointerstitial abnormality (HP:0001969)1.56296185
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.56291469
143Hip dysplasia (HP:0001385)1.56194521
144Osteomalacia (HP:0002749)1.56189799
145Short tibia (HP:0005736)1.55941128
146Abnormal hair whorl (HP:0010721)1.55572185
147Fibular hypoplasia (HP:0003038)1.55150829
148Autoimmune hemolytic anemia (HP:0001890)1.53996587
149Abnormality of the parietal bone (HP:0002696)1.53576511
150Nephrogenic diabetes insipidus (HP:0009806)1.52266394
151Neoplasm of the tracheobronchial system (HP:0100552)1.51947631
152Congenital primary aphakia (HP:0007707)1.51924266
153Hypotelorism (HP:0000601)1.51104830
154Occipital encephalocele (HP:0002085)1.50978410
155Renal agenesis (HP:0000104)1.50272270
156Hypoplasia of the fovea (HP:0007750)1.49868431
157Aplasia/Hypoplasia of the fovea (HP:0008060)1.49868431
158Supernumerary spleens (HP:0009799)1.49443000
159Abnormality of the prostate (HP:0008775)1.49329518
160Aplasia/Hypoplasia of the lens (HP:0008063)1.49293348
161Short thumb (HP:0009778)1.49098847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.92950695
2FER3.68258915
3TXK3.09478590
4EIF2AK22.74154787
5TNIK2.73065606
6ZAK2.51488595
7INSRR2.40134160
8NUAK12.35139384
9GRK12.18688597
10MAP4K22.07146272
11MST42.00235201
12BRD41.98013374
13YES11.97570773
14BMPR21.88075989
15EPHA41.87859231
16MAP3K141.83000028
17MAP2K71.72294547
18UHMK11.67963992
19MKNK21.62716566
20CDK121.61934955
21STK161.55059218
22WNK31.47542015
23CDK31.45209867
24IRAK31.42192932
25NTRK31.41140703
26TNK21.33462825
27NLK1.32954871
28CLK11.32765712
29SIK21.31249512
30MARK11.29576504
31NEK61.27846019
32CAMK1G1.21750283
33BRSK21.19798702
34STK38L1.17803313
35SRPK11.17537182
36JAK11.17406862
37IRAK11.16410793
38STK391.12175951
39NTRK21.11738796
40ADRBK21.11134720
41SGK21.08902118
42IRAK41.08023902
43PINK11.07865357
44CSNK1G11.07430150
45CSNK1G21.06958817
46TEC1.06049346
47ERBB31.03890497
48SIK31.03784076
49PAK31.02549149
50TRIM281.02162329
51CDK91.01526696
52IKBKE1.00643551
53MUSK0.99287659
54ATR0.98441190
55CAMK1D0.95764188
56AKT30.95594030
57MAPK130.94673596
58CSNK1A1L0.93285952
59FLT30.92252052
60PRPF4B0.92155598
61TGFBR10.90371759
62JAK30.90122876
63EIF2AK30.88113575
64EPHA30.86626647
65PLK30.86614422
66OXSR10.86356477
67CSNK1G30.85941821
68WEE10.85351652
69MKNK10.85270821
70MET0.83196051
71TAOK30.82763781
72CDC42BPA0.80836266
73CAMKK20.80153217
74PLK40.78511788
75STK30.77330152
76LATS10.77083601
77PIK3CG0.76893598
78PRKD20.76686364
79TAF10.76201189
80NEK90.75442573
81SGK10.74784622
82BMPR1B0.73730540
83MAPK150.73623587
84TRPM70.73137222
85PKN10.72065139
86FGFR30.71848967
87TTK0.71617346
88IRAK20.69590642
89WNK10.68856286
90PRKCQ0.66711172
91BLK0.65415379
92PRKCE0.63678741
93PAK60.63229993
94MAP3K40.63149599
95MAP3K130.62435985
96PRKD30.62281672
97ATM0.61753370
98CDK80.61216384
99STK380.60691081
100ERBB20.59136008
101STK40.58772659
102MAPK70.58644619
103LCK0.58601944
104HCK0.58293327
105FRK0.57471387
106CCNB10.56405641
107IKBKB0.56345201
108ACVR1B0.56258110
109DYRK1A0.55111246
110RIPK40.54461768
111SGK30.53754447
112PRKAA20.52983956
113CDC70.52694727
114GRK70.52154922
115CHEK20.51329057
116FGFR20.51028267
117TLK10.49968126
118SGK2230.48038418
119SGK4940.48038418
120CDK190.47945953
121CSNK1A10.47510998
122CAMK2A0.47439681
123CAMK10.46852513
124CSNK1D0.46525334
125DYRK20.46425465
126FES0.46234595
127PNCK0.45325111
128PLK20.43201859
129PRKG10.43083952
130PLK10.43058760
131WNK40.43047427
132PRKCG0.42237860
133ERBB40.42037614
134ITK0.42025108
135MINK10.41831850
136BCR0.41776701
137MAP2K20.41600956
138STK110.41466538
139AKT10.40872156
140DAPK20.40067455
141ADRBK10.39658178
142LYN0.39634972
143RPS6KA50.39256378
144MARK30.38101739
145NEK20.37979551
146KIT0.37844110
147MAPK140.37188228
148PRKACB0.33230328
149PRKACA0.33061349
150IGF1R0.32714351

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.72862208
2Fanconi anemia pathway_Homo sapiens_hsa034602.68122378
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.51289934
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28458854
5Non-homologous end-joining_Homo sapiens_hsa034502.12375336
6Nicotine addiction_Homo sapiens_hsa050331.94375012
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93996360
8Butanoate metabolism_Homo sapiens_hsa006501.81518949
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78086844
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70480473
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69288753
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66929098
13Olfactory transduction_Homo sapiens_hsa047401.64845566
14beta-Alanine metabolism_Homo sapiens_hsa004101.64321458
15Primary immunodeficiency_Homo sapiens_hsa053401.61727321
16Propanoate metabolism_Homo sapiens_hsa006401.60150249
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59436809
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.58869589
19Chemical carcinogenesis_Homo sapiens_hsa052041.58508497
20Morphine addiction_Homo sapiens_hsa050321.56074048
21Autoimmune thyroid disease_Homo sapiens_hsa053201.48080576
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47853420
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47813745
24Taste transduction_Homo sapiens_hsa047421.46969801
25Protein export_Homo sapiens_hsa030601.45008010
26Hematopoietic cell lineage_Homo sapiens_hsa046401.39645590
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.36478560
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36359909
29Homologous recombination_Homo sapiens_hsa034401.33475508
30Nitrogen metabolism_Homo sapiens_hsa009101.31793480
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.30703116
32Histidine metabolism_Homo sapiens_hsa003401.29759138
33Gastric acid secretion_Homo sapiens_hsa049711.28846877
34RNA degradation_Homo sapiens_hsa030181.24147454
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22915332
36Graft-versus-host disease_Homo sapiens_hsa053321.22858024
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19043829
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18300699
39Caffeine metabolism_Homo sapiens_hsa002321.17358381
40Calcium signaling pathway_Homo sapiens_hsa040201.15764302
41Measles_Homo sapiens_hsa051621.14763487
42Allograft rejection_Homo sapiens_hsa053301.14721515
43Glutamatergic synapse_Homo sapiens_hsa047241.14358109
44Ovarian steroidogenesis_Homo sapiens_hsa049131.13964784
45Inositol phosphate metabolism_Homo sapiens_hsa005621.08482658
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08252706
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05744761
48Peroxisome_Homo sapiens_hsa041461.03548032
49Hippo signaling pathway_Homo sapiens_hsa043901.02362227
50Retinol metabolism_Homo sapiens_hsa008301.01578080
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01003297
52Serotonergic synapse_Homo sapiens_hsa047261.00791284
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98110014
54T cell receptor signaling pathway_Homo sapiens_hsa046600.96983554
55Long-term depression_Homo sapiens_hsa047300.96355647
56TNF signaling pathway_Homo sapiens_hsa046680.96123618
57cAMP signaling pathway_Homo sapiens_hsa040240.94835206
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.93969701
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93884710
60Sphingolipid metabolism_Homo sapiens_hsa006000.93358042
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93018633
62Tryptophan metabolism_Homo sapiens_hsa003800.92496411
63Herpes simplex infection_Homo sapiens_hsa051680.92375382
64Salivary secretion_Homo sapiens_hsa049700.91490383
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91409795
66ABC transporters_Homo sapiens_hsa020100.91381860
67Basal cell carcinoma_Homo sapiens_hsa052170.91130844
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90542821
69Dopaminergic synapse_Homo sapiens_hsa047280.90538124
70Circadian entrainment_Homo sapiens_hsa047130.90435519
71Insulin secretion_Homo sapiens_hsa049110.88482534
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87956006
73Oxytocin signaling pathway_Homo sapiens_hsa049210.87935156
74TGF-beta signaling pathway_Homo sapiens_hsa043500.87558779
75Cocaine addiction_Homo sapiens_hsa050300.87136316
76Ether lipid metabolism_Homo sapiens_hsa005650.86273020
77Selenocompound metabolism_Homo sapiens_hsa004500.86085656
78Chemokine signaling pathway_Homo sapiens_hsa040620.84293353
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83263369
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82786789
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80845201
82Dorso-ventral axis formation_Homo sapiens_hsa043200.79027234
83RNA transport_Homo sapiens_hsa030130.76144315
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75291235
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75142056
86Renin secretion_Homo sapiens_hsa049240.74595494
87Osteoclast differentiation_Homo sapiens_hsa043800.74372286
88Axon guidance_Homo sapiens_hsa043600.73889731
89Small cell lung cancer_Homo sapiens_hsa052220.73778717
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73714493
91Thyroid hormone synthesis_Homo sapiens_hsa049180.72996583
92Wnt signaling pathway_Homo sapiens_hsa043100.72949686
93Synaptic vesicle cycle_Homo sapiens_hsa047210.71498727
94Basal transcription factors_Homo sapiens_hsa030220.71458627
95Rheumatoid arthritis_Homo sapiens_hsa053230.71160055
96Type I diabetes mellitus_Homo sapiens_hsa049400.70703692
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.70638686
98Vitamin digestion and absorption_Homo sapiens_hsa049770.70616230
99Arachidonic acid metabolism_Homo sapiens_hsa005900.69702451
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69428174
101Choline metabolism in cancer_Homo sapiens_hsa052310.68987943
102Ras signaling pathway_Homo sapiens_hsa040140.67993445
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67332038
104Melanoma_Homo sapiens_hsa052180.66740715
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.66308127
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66085200
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65996049
108Type II diabetes mellitus_Homo sapiens_hsa049300.65804349
109Malaria_Homo sapiens_hsa051440.65330870
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63106469
111Cholinergic synapse_Homo sapiens_hsa047250.62843761
112Prostate cancer_Homo sapiens_hsa052150.61917438
113ECM-receptor interaction_Homo sapiens_hsa045120.61450523
114Asthma_Homo sapiens_hsa053100.61148277
115Nucleotide excision repair_Homo sapiens_hsa034200.60728360
116Linoleic acid metabolism_Homo sapiens_hsa005910.60688087
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60388683
118MAPK signaling pathway_Homo sapiens_hsa040100.59738006
119Systemic lupus erythematosus_Homo sapiens_hsa053220.59437737
120Amphetamine addiction_Homo sapiens_hsa050310.59383920
121Hedgehog signaling pathway_Homo sapiens_hsa043400.59058035
122Glycerolipid metabolism_Homo sapiens_hsa005610.58386411
123Influenza A_Homo sapiens_hsa051640.57951026
124Huntingtons disease_Homo sapiens_hsa050160.57775902
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56460766
126African trypanosomiasis_Homo sapiens_hsa051430.56349901
127Oocyte meiosis_Homo sapiens_hsa041140.55971031
128Melanogenesis_Homo sapiens_hsa049160.55202934
129Pathways in cancer_Homo sapiens_hsa052000.53937057
130Rap1 signaling pathway_Homo sapiens_hsa040150.53359678
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53171523
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52530407
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.52300944
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.51739760
135ErbB signaling pathway_Homo sapiens_hsa040120.51727745
136GABAergic synapse_Homo sapiens_hsa047270.51443021
137Tight junction_Homo sapiens_hsa045300.51198088
138Lysine degradation_Homo sapiens_hsa003100.50559460
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50482721
140Circadian rhythm_Homo sapiens_hsa047100.50064015
141Prolactin signaling pathway_Homo sapiens_hsa049170.47349094
142Hepatitis B_Homo sapiens_hsa051610.46623915
143HTLV-I infection_Homo sapiens_hsa051660.46431369
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46310078
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45444992
146Protein digestion and absorption_Homo sapiens_hsa049740.45021443
147mRNA surveillance pathway_Homo sapiens_hsa030150.44983134
148p53 signaling pathway_Homo sapiens_hsa041150.43861782
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42974971
150Alcoholism_Homo sapiens_hsa050340.39917206
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39285115
152Vitamin B6 metabolism_Homo sapiens_hsa007500.38586248
153N-Glycan biosynthesis_Homo sapiens_hsa005100.38092929
154Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36272908

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