IFT81

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, together with IFT74, forms a tubulin-binding module of intraflagellar transport complex B. This module is involved in transport of tubulin within the cilium, and the encoded protein is required for ciliogenesis. Mutations in this gene are a cause of short-rib polydactyly syndromes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of calcium ion (GO:0005513)4.29543247
2cilium movement (GO:0003341)4.10145345
3* intraciliary transport (GO:0042073)3.98860534
4cilium or flagellum-dependent cell motility (GO:0001539)3.84868781
5behavioral response to nicotine (GO:0035095)3.76174793
6pyrimidine nucleobase catabolic process (GO:0006208)3.71457633
7epithelial cilium movement (GO:0003351)3.65023694
8axoneme assembly (GO:0035082)3.53238988
9axonemal dynein complex assembly (GO:0070286)3.51842188
10microtubule depolymerization (GO:0007019)3.49651542
11protein localization to cilium (GO:0061512)3.44395469
12regulation of cilium movement (GO:0003352)3.42192617
13limb bud formation (GO:0060174)3.41730503
14neural tube formation (GO:0001841)3.40978411
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32996269
16neuron cell-cell adhesion (GO:0007158)3.26760617
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.26069924
18retinal ganglion cell axon guidance (GO:0031290)3.24062458
19presynaptic membrane assembly (GO:0097105)3.20578082
20membrane repolarization during action potential (GO:0086011)3.17805387
21synaptic vesicle exocytosis (GO:0016079)3.16759255
22somite development (GO:0061053)3.09714421
23regulation of short-term neuronal synaptic plasticity (GO:0048172)3.09203451
24centriole replication (GO:0007099)3.07865700
25regulation of synaptic vesicle exocytosis (GO:2000300)3.06200429
26nucleobase catabolic process (GO:0046113)3.03417679
27protein polyglutamylation (GO:0018095)3.00128031
28olfactory bulb development (GO:0021772)2.98646806
29membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.95545364
30cornea development in camera-type eye (GO:0061303)2.93830361
31DNA double-strand break processing (GO:0000729)2.92404777
32regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.92065449
33resolution of meiotic recombination intermediates (GO:0000712)2.91320608
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.90487577
35Golgi transport vesicle coating (GO:0048200)2.88466544
36COPI coating of Golgi vesicle (GO:0048205)2.88466544
37regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.87728794
38ventricular system development (GO:0021591)2.86501368
39nonmotile primary cilium assembly (GO:0035058)2.84591378
40vocalization behavior (GO:0071625)2.84319654
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.82452358
42postsynaptic membrane organization (GO:0001941)2.81546803
43lactate metabolic process (GO:0006089)2.80977770
44synaptic vesicle docking involved in exocytosis (GO:0016081)2.80885486
45neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.79242255
46left/right axis specification (GO:0070986)2.75836949
47regulation of membrane repolarization (GO:0060306)2.75702491
48protein localization to synapse (GO:0035418)2.75481165
49regulation of synaptic vesicle transport (GO:1902803)2.75141309
50neuron recognition (GO:0008038)2.74364381
51neuron fate determination (GO:0048664)2.72360335
52cerebellar Purkinje cell differentiation (GO:0021702)2.71668013
53presynaptic membrane organization (GO:0097090)2.71635350
54* cilium assembly (GO:0042384)2.70457775
55* cilium organization (GO:0044782)2.69920176
56microtubule polymerization or depolymerization (GO:0031109)2.69609062
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.67896230
58regulation of microtubule-based movement (GO:0060632)2.66967257
59calcium ion-dependent exocytosis (GO:0017156)2.65121285
60neuronal stem cell maintenance (GO:0097150)2.64895371
61cilium morphogenesis (GO:0060271)2.64136725
62cell proliferation in forebrain (GO:0021846)2.64092918
63forebrain neuron differentiation (GO:0021879)2.63512883
64left/right pattern formation (GO:0060972)2.61783222
65negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61386269
66regulation of timing of cell differentiation (GO:0048505)2.61286185
67limb development (GO:0060173)2.60614754
68appendage development (GO:0048736)2.60614754
69regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.59968666
70regulation of development, heterochronic (GO:0040034)2.59423697
71spinal cord motor neuron differentiation (GO:0021522)2.59292204
72piRNA metabolic process (GO:0034587)2.59272607
73striatum development (GO:0021756)2.58340670
74insulin secretion (GO:0030073)2.58228655
75axonal fasciculation (GO:0007413)2.57476716
76microtubule bundle formation (GO:0001578)2.57109356
77sperm motility (GO:0030317)2.56790428
78positive regulation of oligodendrocyte differentiation (GO:0048714)2.56309585
79head development (GO:0060322)2.55529961
80cell communication by electrical coupling (GO:0010644)2.54923916
81membrane repolarization (GO:0086009)2.54116201
82spinal cord development (GO:0021510)2.53699979
83transmission of nerve impulse (GO:0019226)2.53474990
84regulation of sarcomere organization (GO:0060297)2.53346380
85detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52379938
86urinary tract smooth muscle contraction (GO:0014848)2.51245121
87regulation of glutamate receptor signaling pathway (GO:1900449)2.51072257
88startle response (GO:0001964)2.50806387
89positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.50579270
90regulation of DNA endoreduplication (GO:0032875)2.50482221
91negative regulation of axon guidance (GO:1902668)2.50479777
92ER overload response (GO:0006983)2.49589347
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49574903
94synapsis (GO:0007129)2.48108353
95determination of left/right symmetry (GO:0007368)2.47877383
96type B pancreatic cell development (GO:0003323)2.47799304
97response to pheromone (GO:0019236)2.47052005
98motile cilium assembly (GO:0044458)2.46889019
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.45828818
100regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.45366921
101replication fork processing (GO:0031297)2.45060931
102glutamate secretion (GO:0014047)2.44839453
103cell differentiation in spinal cord (GO:0021515)2.44305455
104acrosome assembly (GO:0001675)2.43597063
105innervation (GO:0060384)2.42556427
106male meiosis (GO:0007140)2.41805816
107cerebellum development (GO:0021549)2.41693254
108determination of bilateral symmetry (GO:0009855)2.41482746
109acrosome reaction (GO:0007340)2.41305548
110behavioral response to ethanol (GO:0048149)2.40776749
111membrane depolarization during action potential (GO:0086010)2.38637615
112* cellular component assembly involved in morphogenesis (GO:0010927)2.38197448
113photoreceptor cell maintenance (GO:0045494)2.37776816
114neurotransmitter secretion (GO:0007269)2.37181817
115regulation of heart rate by cardiac conduction (GO:0086091)2.35954929
116male meiosis I (GO:0007141)2.35764286
117regulation of potassium ion transmembrane transport (GO:1901379)2.35500327
118specification of symmetry (GO:0009799)2.35456826
119neurotransmitter-gated ion channel clustering (GO:0072578)2.34637734
120positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.33510860
121locomotory exploration behavior (GO:0035641)2.33366059
122reciprocal DNA recombination (GO:0035825)2.32562392
123reciprocal meiotic recombination (GO:0007131)2.32562392
124endocrine pancreas development (GO:0031018)2.32329530
125regulation of meiosis I (GO:0060631)2.31577451
126hindbrain development (GO:0030902)2.31280155
127negative regulation of oligodendrocyte differentiation (GO:0048715)2.30547039
128sympathetic nervous system development (GO:0048485)2.29417313
129cardiac conduction (GO:0061337)2.29282998
130dendritic spine morphogenesis (GO:0060997)2.29168038
131positive regulation of potassium ion transport (GO:0043268)2.29156409
132long-term synaptic potentiation (GO:0060291)2.28843573
133otic vesicle formation (GO:0030916)2.28795847
134central nervous system projection neuron axonogenesis (GO:0021952)2.28592548
135sequestering of actin monomers (GO:0042989)2.27964808
136DNA methylation involved in gamete generation (GO:0043046)2.27415307
137calcium ion import (GO:0070509)2.26833583
138dorsal/ventral pattern formation (GO:0009953)2.26693779
139smoothened signaling pathway (GO:0007224)2.26447808
140negative regulation of astrocyte differentiation (GO:0048712)2.26053999
141protein targeting to Golgi (GO:0000042)2.25983288
142negative regulation of cytosolic calcium ion concentration (GO:0051481)2.25349942
143inner ear receptor stereocilium organization (GO:0060122)2.24910416
144positive regulation of meiosis (GO:0045836)2.24758847
145regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.24540747
146synaptic vesicle maturation (GO:0016188)2.24487769
147regulation of oligodendrocyte differentiation (GO:0048713)2.24353785
148relaxation of cardiac muscle (GO:0055119)2.24125633
149cerebral cortex radially oriented cell migration (GO:0021799)2.24068878
150negative regulation of DNA-dependent DNA replication (GO:2000104)2.23782799
151central nervous system neuron axonogenesis (GO:0021955)2.23694405
152positive regulation of potassium ion transmembrane transport (GO:1901381)2.23217140
153peptide hormone processing (GO:0016486)2.23156902
154cardiac myofibril assembly (GO:0055003)2.22957085
155embryonic epithelial tube formation (GO:0001838)2.22286524
156glandular epithelial cell differentiation (GO:0002067)2.21876001
157ATP hydrolysis coupled proton transport (GO:0015991)2.21636071
158energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.21636071
159regulation of calcium ion-dependent exocytosis (GO:0017158)2.21534675
160* microtubule-based movement (GO:0007018)2.21387539
161histone H2A acetylation (GO:0043968)2.20994488
162kidney morphogenesis (GO:0060993)2.20834150
163calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.20432124
164hippocampus development (GO:0021766)2.20383637
165seminiferous tubule development (GO:0072520)2.19785892
166photoreceptor cell development (GO:0042461)2.19252848
167retinal rod cell development (GO:0046548)2.19091571
168mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.19086933
169regulation of insulin secretion (GO:0050796)2.18502448
170positive regulation of synapse maturation (GO:0090129)2.17615866
171exploration behavior (GO:0035640)2.17490351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.99697034
2GBX2_23144817_ChIP-Seq_PC3_Human3.47264427
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.19893297
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.59079570
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26163816
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.25454334
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.07003665
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06687872
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04930461
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00230123
11EZH2_27304074_Chip-Seq_ESCs_Mouse1.99735873
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98231331
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97855537
14ZNF274_21170338_ChIP-Seq_K562_Hela1.95647783
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94671650
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93859279
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89399829
18REST_21632747_ChIP-Seq_MESCs_Mouse1.89262308
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.87580701
20SMAD4_21799915_ChIP-Seq_A2780_Human1.85650171
21VDR_22108803_ChIP-Seq_LS180_Human1.85124929
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.84823144
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84441486
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79713569
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78703498
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.73683526
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72688084
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72618535
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72477406
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72477406
31P300_19829295_ChIP-Seq_ESCs_Human1.72402770
32FUS_26573619_Chip-Seq_HEK293_Human1.71596073
33TAF15_26573619_Chip-Seq_HEK293_Human1.70814452
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69768318
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68846144
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68407099
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67151147
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64216786
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63673564
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.62267448
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.62250461
42RNF2_27304074_Chip-Seq_NSC_Mouse1.61837451
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.61413546
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61007786
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60749071
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59648103
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.59198101
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56894438
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.56625604
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.56585820
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55990762
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46196981
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45829031
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45674079
55DROSHA_22980978_ChIP-Seq_HELA_Human1.45670996
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.45426076
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44355487
58* STAT3_23295773_ChIP-Seq_U87_Human1.43302489
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.43018008
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42778986
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41263061
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36844922
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33056681
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32329702
65* TCF4_23295773_ChIP-Seq_U87_Human1.31876492
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.30334217
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.30245656
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27846987
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27840301
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27067014
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26004420
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25563084
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25400266
74* RARB_27405468_Chip-Seq_BRAIN_Mouse1.24173746
75AR_25329375_ChIP-Seq_VCAP_Human1.23823808
76MYC_18940864_ChIP-ChIP_HL60_Human1.23085991
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22994574
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.21715325
79IRF1_19129219_ChIP-ChIP_H3396_Human1.21080872
80TCF4_22108803_ChIP-Seq_LS180_Human1.20848014
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20841474
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19163494
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18943640
84IGF1R_20145208_ChIP-Seq_DFB_Human1.18483190
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16346794
86ER_23166858_ChIP-Seq_MCF-7_Human1.16060381
87BCAT_22108803_ChIP-Seq_LS180_Human1.15230586
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.14849810
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14251556
90RUNX2_22187159_ChIP-Seq_PCA_Human1.14248202
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12876113
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12096216
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11906108
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11372000
95CBP_20019798_ChIP-Seq_JUKART_Human1.11245370
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11245370
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.11108571
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10637941
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10479542
100ELK1_19687146_ChIP-ChIP_HELA_Human1.10466328
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10384442
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09700594
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09649076
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09649076
105TP53_22573176_ChIP-Seq_HFKS_Human1.08933284
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08814552
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.08630473
108GABP_17652178_ChIP-ChIP_JURKAT_Human1.07254482
109* AR_19668381_ChIP-Seq_PC3_Human1.06941800
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06322523
111JUN_21703547_ChIP-Seq_K562_Human1.05279084
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.04925253
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.04571346
114NANOG_19829295_ChIP-Seq_ESCs_Human1.04206058
115SOX2_19829295_ChIP-Seq_ESCs_Human1.04206058
116KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04201742
117SOX9_26525672_Chip-Seq_HEART_Mouse1.04150653
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03200790
119PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01861191
120P53_22387025_ChIP-Seq_ESCs_Mouse1.01257471
121FLI1_27457419_Chip-Seq_LIVER_Mouse1.01236871
122AR_21572438_ChIP-Seq_LNCaP_Human1.00502970
123EWS_26573619_Chip-Seq_HEK293_Human1.00312701
124KDM2B_26808549_Chip-Seq_REH_Human0.99594161
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99170476
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98827771
127E2F1_18555785_Chip-Seq_ESCs_Mouse0.98427480
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.97559402
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96473468
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95092841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.29925218
2MP0003122_maternal_imprinting2.95246150
3MP0003136_yellow_coat_color2.77742418
4MP0003880_abnormal_central_pattern2.60608267
5MP0001984_abnormal_olfaction2.50420955
6MP0009780_abnormal_chondrocyte_physiolo2.47325394
7MP0005646_abnormal_pituitary_gland2.27476328
8MP0006072_abnormal_retinal_apoptosis2.23647916
9MP0000013_abnormal_adipose_tissue2.20111815
10MP0004859_abnormal_synaptic_plasticity2.19547951
11MP0002102_abnormal_ear_morphology2.13975156
12MP0003635_abnormal_synaptic_transmissio2.06260677
13MP0002909_abnormal_adrenal_gland2.02171764
14MP0004270_analgesia2.00746751
15MP0010386_abnormal_urinary_bladder1.82661211
16MP0004215_abnormal_myocardial_fiber1.78873823
17MP0000372_irregular_coat_pigmentation1.72459008
18MP0002063_abnormal_learning/memory/cond1.71801323
19MP0002734_abnormal_mechanical_nocicepti1.69683602
20MP0003787_abnormal_imprinting1.63937265
21MP0004043_abnormal_pH_regulation1.62168362
22MP0002572_abnormal_emotion/affect_behav1.61631812
23MP0000569_abnormal_digit_pigmentation1.61066507
24MP0005551_abnormal_eye_electrophysiolog1.59975931
25MP0005645_abnormal_hypothalamus_physiol1.58389024
26MP0003121_genomic_imprinting1.56967474
27MP0005410_abnormal_fertilization1.55458057
28MP0009745_abnormal_behavioral_response1.55181852
29MP0000566_synostosis1.55059273
30MP0002822_catalepsy1.53776671
31MP0003937_abnormal_limbs/digits/tail_de1.53386470
32MP0006276_abnormal_autonomic_nervous1.51408601
33MP0001293_anophthalmia1.50786469
34MP0002272_abnormal_nervous_system1.49986044
35MP0002877_abnormal_melanocyte_morpholog1.48685776
36MP0002638_abnormal_pupillary_reflex1.48594893
37MP0009046_muscle_twitch1.46874105
38MP0004145_abnormal_muscle_electrophysio1.46304715
39MP0000631_abnormal_neuroendocrine_gland1.45184167
40MP0000778_abnormal_nervous_system1.45061807
41MP0003283_abnormal_digestive_organ1.44400968
42MP0005379_endocrine/exocrine_gland_phen1.43626412
43MP0002064_seizures1.43249291
44MP0001486_abnormal_startle_reflex1.42030169
45MP0000678_abnormal_parathyroid_gland1.40667564
46MP0005248_abnormal_Harderian_gland1.37923384
47MP0004142_abnormal_muscle_tone1.35788865
48MP0008995_early_reproductive_senescence1.35331534
49MP0002557_abnormal_social/conspecific_i1.32601243
50MP0008877_abnormal_DNA_methylation1.32172711
51MP0002234_abnormal_pharynx_morphology1.30703971
52MP0004084_abnormal_cardiac_muscle1.29181502
53MP0002751_abnormal_autonomic_nervous1.28966270
54MP0001944_abnormal_pancreas_morphology1.28710344
55MP0002233_abnormal_nose_morphology1.28672953
56MP0004233_abnormal_muscle_weight1.28018830
57MP0005253_abnormal_eye_physiology1.27445936
58MP0010030_abnormal_orbit_morphology1.26457670
59MP0002184_abnormal_innervation1.26370213
60MP0001188_hyperpigmentation1.25239727
61MP0005423_abnormal_somatic_nervous1.24596075
62MP0004085_abnormal_heartbeat1.24499324
63MP0000026_abnormal_inner_ear1.24266331
64MP0002693_abnormal_pancreas_physiology1.23871545
65MP0001502_abnormal_circadian_rhythm1.23753191
66MP0000751_myopathy1.22762789
67MP0003183_abnormal_peptide_metabolism1.20820526
68MP0004885_abnormal_endolymph1.19106120
69MP0002160_abnormal_reproductive_system1.18664077
70MP0008058_abnormal_DNA_repair1.18110262
71MP0004036_abnormal_muscle_relaxation1.16245689
72MP0003123_paternal_imprinting1.16144671
73MP0001968_abnormal_touch/_nociception1.15710965
74MP0003137_abnormal_impulse_conducting1.15363540
75MP0002067_abnormal_sensory_capabilities1.15121995
76MP0002210_abnormal_sex_determination1.12590276
77MP0001440_abnormal_grooming_behavior1.10153481
78MP0005195_abnormal_posterior_eye1.09867678
79MP0003755_abnormal_palate_morphology1.09450533
80MP0002282_abnormal_trachea_morphology1.07454736
81MP0003861_abnormal_nervous_system1.06825730
82MP0003938_abnormal_ear_development1.05417004
83MP0001529_abnormal_vocalization1.05171220
84MP0004924_abnormal_behavior1.05112005
85MP0005386_behavior/neurological_phenoty1.05112005
86MP0005394_taste/olfaction_phenotype1.04461252
87MP0005499_abnormal_olfactory_system1.04461252
88MP0002653_abnormal_ependyma_morphology1.03731999
89MP0005391_vision/eye_phenotype1.03592257
90MP0002882_abnormal_neuron_morphology1.03141520
91MP0001929_abnormal_gametogenesis1.03107614
92MP0005174_abnormal_tail_pigmentation1.02594792
93MP0001286_abnormal_eye_development1.01972974
94MP0002938_white_spotting1.01455460
95MP0003942_abnormal_urinary_system1.00596854
96MP0003698_abnormal_male_reproductive0.99675935
97MP0000647_abnormal_sebaceous_gland0.99542209
98MP0002095_abnormal_skin_pigmentation0.99409413
99MP0008789_abnormal_olfactory_epithelium0.99115440
100MP0000427_abnormal_hair_cycle0.98101603
101MP0001299_abnormal_eye_distance/0.97535869
102MP0003567_abnormal_fetal_cardiomyocyte0.96969857
103MP0001970_abnormal_pain_threshold0.96221498
104MP0002733_abnormal_thermal_nociception0.95228707
105MP0000955_abnormal_spinal_cord0.94411120
106MP0000383_abnormal_hair_follicle0.94065415
107MP0005171_absent_coat_pigmentation0.92874843
108MP0000653_abnormal_sex_gland0.92654555
109MP0000003_abnormal_adipose_tissue0.92457046
110MP0001324_abnormal_eye_pigmentation0.92270013
111MP0003890_abnormal_embryonic-extraembry0.91323859
112MP0001963_abnormal_hearing_physiology0.91321997
113MP0001501_abnormal_sleep_pattern0.91313914
114MP0001485_abnormal_pinna_reflex0.91261368
115MP0003119_abnormal_digestive_system0.90599189
116MP0000534_abnormal_ureter_morphology0.90279529
117MP0001145_abnormal_male_reproductive0.89990701
118MP0006292_abnormal_olfactory_placode0.88363993
119MP0004811_abnormal_neuron_physiology0.88342119
120MP0005389_reproductive_system_phenotype0.87781376
121MP0002735_abnormal_chemical_nociception0.86550634
122MP0002152_abnormal_brain_morphology0.86539002
123MP0003718_maternal_effect0.85272949
124MP0002972_abnormal_cardiac_muscle0.83638379
125MP0003646_muscle_fatigue0.82799753
126MP0005620_abnormal_muscle_contractility0.82526320
127MP0000049_abnormal_middle_ear0.82424691
128MP0004484_altered_response_of0.81618960
129MP0002736_abnormal_nociception_after0.81063142
130MP0005187_abnormal_penis_morphology0.80073212
131MP0002066_abnormal_motor_capabilities/c0.79841295
132MP0003879_abnormal_hair_cell0.79823794
133MP0004133_heterotaxia0.79051058
134MP0005623_abnormal_meninges_morphology0.77932803
135MP0002752_abnormal_somatic_nervous0.77882127
136MP0000516_abnormal_urinary_system0.77809998
137MP0005367_renal/urinary_system_phenotyp0.77809998
138MP0002928_abnormal_bile_duct0.77624356
139MP0006138_congestive_heart_failure0.76318644
140MP0008569_lethality_at_weaning0.75974738

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.79955583
2Abnormal respiratory motile cilium physiology (HP:0012261)4.28877898
3Abnormal ciliary motility (HP:0012262)4.00716542
4Absent/shortened dynein arms (HP:0200106)3.85643613
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.85643613
6Medial flaring of the eyebrow (HP:0010747)3.81775144
7Gait imbalance (HP:0002141)3.73326285
8Congenital primary aphakia (HP:0007707)3.55672572
9Chronic bronchitis (HP:0004469)3.48354990
10Abnormal respiratory motile cilium morphology (HP:0005938)3.48296246
11Abnormal respiratory epithelium morphology (HP:0012253)3.48296246
12Rhinitis (HP:0012384)3.38945315
13Nephrogenic diabetes insipidus (HP:0009806)3.24127436
14True hermaphroditism (HP:0010459)2.99059458
15Vaginal atresia (HP:0000148)2.93083747
16Genital tract atresia (HP:0001827)2.92423963
17Nephronophthisis (HP:0000090)2.86983760
18Pancreatic fibrosis (HP:0100732)2.82894660
19Focal motor seizures (HP:0011153)2.79629210
20Abnormality of midbrain morphology (HP:0002418)2.79247830
21Molar tooth sign on MRI (HP:0002419)2.79247830
22Abnormality of the labia minora (HP:0012880)2.76866457
23Sclerocornea (HP:0000647)2.76850982
24Atonic seizures (HP:0010819)2.70348999
25Hyperinsulinemic hypoglycemia (HP:0000825)2.65644148
26Epileptic encephalopathy (HP:0200134)2.63600812
27Type II lissencephaly (HP:0007260)2.59678738
28Poor coordination (HP:0002370)2.59482915
29Volvulus (HP:0002580)2.51779920
30Anencephaly (HP:0002323)2.51226975
31Hypothermia (HP:0002045)2.50600894
32Tubulointerstitial nephritis (HP:0001970)2.49808084
33Central scotoma (HP:0000603)2.48379513
34Aplasia/Hypoplasia of the lens (HP:0008063)2.46451781
35Male pseudohermaphroditism (HP:0000037)2.44715467
36Visual hallucinations (HP:0002367)2.43619416
37Abnormality of the renal cortex (HP:0011035)2.41709841
38Prolonged QT interval (HP:0001657)2.39127772
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.38153986
40Left ventricular hypertrophy (HP:0001712)2.37461192
41Bifid tongue (HP:0010297)2.35274629
42Preaxial hand polydactyly (HP:0001177)2.34818373
43Lissencephaly (HP:0001339)2.33140796
44Absent eyebrow (HP:0002223)2.29769491
45Cystic liver disease (HP:0006706)2.27434213
46Decreased circulating renin level (HP:0003351)2.26983247
47Pheochromocytoma (HP:0002666)2.26884441
48Abnormality of the renal medulla (HP:0100957)2.25380366
49Intestinal atresia (HP:0011100)2.25349703
50Tubular atrophy (HP:0000092)2.25040339
51Hyperventilation (HP:0002883)2.20824045
52Oligodactyly (hands) (HP:0001180)2.20300336
53Acute necrotizing encephalopathy (HP:0006965)2.17325988
54Cerebellar dysplasia (HP:0007033)2.16501175
55Febrile seizures (HP:0002373)2.14855756
56Pancreatic cysts (HP:0001737)2.14110677
57Focal seizures (HP:0007359)2.13185435
58Papillary thyroid carcinoma (HP:0002895)2.12564154
59Supernumerary spleens (HP:0009799)2.09917746
60Progressive macrocephaly (HP:0004481)2.07829392
61Occipital encephalocele (HP:0002085)2.06625758
62Narrow forehead (HP:0000341)2.05752689
63Syncope (HP:0001279)2.04964926
64Anophthalmia (HP:0000528)2.01985730
65Abnormal mitochondria in muscle tissue (HP:0008316)2.01400210
66Postaxial hand polydactyly (HP:0001162)2.01028329
67Polydipsia (HP:0001959)1.99615365
68Abnormal drinking behavior (HP:0030082)1.99615365
69Atrial fibrillation (HP:0005110)1.98512058
70Absence seizures (HP:0002121)1.97140565
71Aganglionic megacolon (HP:0002251)1.96940313
72Epileptiform EEG discharges (HP:0011182)1.95155249
73Specific learning disability (HP:0001328)1.93909873
74Dandy-Walker malformation (HP:0001305)1.93749761
75Abnormal pancreas size (HP:0012094)1.92878076
76Progressive cerebellar ataxia (HP:0002073)1.92108059
77EEG with generalized epileptiform discharges (HP:0011198)1.92086135
78Hyperglycinemia (HP:0002154)1.92008527
79Ketoacidosis (HP:0001993)1.90677024
80Hypoglycemic seizures (HP:0002173)1.90538227
81Infertility (HP:0000789)1.89852832
82Primary atrial arrhythmia (HP:0001692)1.89210536
83Thyroid-stimulating hormone excess (HP:0002925)1.88828485
84Congenital stationary night blindness (HP:0007642)1.88073260
85Optic nerve hypoplasia (HP:0000609)1.87971532
86Insulin-resistant diabetes mellitus (HP:0000831)1.87925933
87Aplasia/Hypoplasia of the tibia (HP:0005772)1.87594320
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.86618513
89Abnormal biliary tract physiology (HP:0012439)1.86027464
90Bile duct proliferation (HP:0001408)1.86027464
91Astigmatism (HP:0000483)1.84900630
92Oculomotor apraxia (HP:0000657)1.84623047
93Abnormality of macular pigmentation (HP:0008002)1.84517213
94Abnormality of dentin (HP:0010299)1.84227684
95Multicystic kidney dysplasia (HP:0000003)1.83872486
96Hyperglycemia (HP:0003074)1.83716201
97Micropenis (HP:0000054)1.83188391
98Pachygyria (HP:0001302)1.81732106
99Aplasia/Hypoplasia of the sternum (HP:0006714)1.81649431
100Prominent nasal bridge (HP:0000426)1.81593160
101Neuroendocrine neoplasm (HP:0100634)1.81229398
102Agitation (HP:0000713)1.79644020
103Ventricular fibrillation (HP:0001663)1.78725349
104Abnormal EKG (HP:0003115)1.78554252
105Pancreatic islet-cell hyperplasia (HP:0004510)1.77712943
106Symptomatic seizures (HP:0011145)1.77679789
107Rib fusion (HP:0000902)1.77081034
108Hypsarrhythmia (HP:0002521)1.77044151
109Chronic hepatic failure (HP:0100626)1.77028458
110Tubulointerstitial abnormality (HP:0001969)1.76669498
111Hepatoblastoma (HP:0002884)1.74132653
112Median cleft lip (HP:0000161)1.73696337
113Highly arched eyebrow (HP:0002553)1.73502915
114Oligodactyly (HP:0012165)1.72999282
115Supraventricular tachycardia (HP:0004755)1.72628653
116Broad foot (HP:0001769)1.72554235
117Genetic anticipation (HP:0003743)1.72117163
118Aplasia/Hypoplasia of the tongue (HP:0010295)1.71572311
119Postaxial foot polydactyly (HP:0001830)1.71355993
120Truncal ataxia (HP:0002078)1.71028424
121Septo-optic dysplasia (HP:0100842)1.69844365
122Supraventricular arrhythmia (HP:0005115)1.69524503
123Large for gestational age (HP:0001520)1.68939002
124Hypokalemia (HP:0002900)1.68655185
125Bony spicule pigmentary retinopathy (HP:0007737)1.68496902
126Decreased testicular size (HP:0008734)1.68444348
127Gastrointestinal atresia (HP:0002589)1.68254516
128Generalized tonic-clonic seizures (HP:0002069)1.67924652
129Dialeptic seizures (HP:0011146)1.67657787
130Scotoma (HP:0000575)1.66875194
131Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66870327
132Facial cleft (HP:0002006)1.66597555
133Small hand (HP:0200055)1.66409684
134Sudden death (HP:0001699)1.66211086
135Excessive salivation (HP:0003781)1.65532107
136Drooling (HP:0002307)1.65532107
137Sloping forehead (HP:0000340)1.65300785
138Renal hypoplasia (HP:0000089)1.64418718
139Colon cancer (HP:0003003)1.64107595
140Cutaneous finger syndactyly (HP:0010554)1.64085085
141Failure to thrive in infancy (HP:0001531)1.63397777
142Patellar aplasia (HP:0006443)1.62691405
143Congenital hepatic fibrosis (HP:0002612)1.62070365
144Pendular nystagmus (HP:0012043)1.59919826
145Bronchiectasis (HP:0002110)1.59666137
146Labial hypoplasia (HP:0000066)1.59607035
147Gaze-evoked nystagmus (HP:0000640)1.59076522
148Abnormality of calcium-phosphate metabolism (HP:0100530)1.58918553
149Abnormal lung lobation (HP:0002101)1.58858157
150Furrowed tongue (HP:0000221)1.58691615
151Short foot (HP:0001773)1.58150240
152Broad-based gait (HP:0002136)1.57932435
153Holoprosencephaly (HP:0001360)1.57923220
154Fibular hypoplasia (HP:0003038)1.57396214
155Limb dystonia (HP:0002451)1.56874762
156Retinal dysplasia (HP:0007973)1.53422773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.24726456
2NTRK33.13902416
3MAP4K22.99664290
4PRKD32.92257185
5INSRR2.81872066
6MAP3K42.81553662
7MAPK152.66683932
8PNCK2.63269168
9PDK42.57496453
10PDK32.57496453
11MAP2K72.52570052
12MARK12.16872784
13FRK2.10882020
14AKT31.94808338
15WEE11.92828254
16TNIK1.88424579
17EPHA41.85105923
18TRIM281.79545921
19NUAK11.75596462
20WNK41.72919568
21WNK31.69285718
22MAPK131.62277246
23PASK1.59119150
24ZAK1.58639984
25BRSK21.57186344
26MKNK21.50372349
27UHMK11.49846881
28PLK21.44242326
29SGK21.41478398
30ERBB31.39779399
31DYRK21.37998484
32CSNK1G11.35855893
33PLK41.35123206
34CSNK1G31.34416589
35MKNK11.33077269
36PAK31.32946578
37SGK2231.31272041
38SGK4941.31272041
39PDK21.29956327
40CCNB11.28567857
41ADRBK21.21696129
42PHKG21.21200563
43PHKG11.21200563
44CAMK1G1.16634763
45CSNK1A1L1.16179456
46MINK11.15660674
47CAMKK21.14633976
48CDC71.13182650
49NTRK21.12568663
50HIPK21.10287024
51GRK11.09048842
52PAK61.04555036
53CDC42BPA1.04151056
54MAP3K21.02897216
55GRK71.02212219
56LMTK21.01425601
57STK38L1.01255724
58DYRK30.99517570
59MAP2K40.98528984
60OBSCN0.98164063
61BMPR1B0.94899219
62TLK10.94884698
63VRK10.94433152
64CAMK2D0.94342993
65CAMK2A0.92595728
66KSR10.92419690
67PRKCG0.92165954
68EPHA30.90019605
69FER0.89772777
70BCR0.89108795
71CDK190.87991139
72PRKCE0.87564166
73PLK10.86562337
74PTK2B0.84067506
75ACVR1B0.83475964
76DAPK20.82398862
77WNK10.81237856
78BRAF0.79973265
79SGK30.79295404
80DYRK1A0.78683510
81CDK50.76084631
82MUSK0.75404236
83MAP3K90.74165412
84BMPR20.73852117
85STK390.72167922
86NEK10.70666221
87MYLK0.70488097
88BCKDK0.69688845
89GRK50.69074051
90CAMK2B0.68767164
91PLK30.66942094
92CDK30.66742618
93STK380.66490145
94NEK20.63928466
95STK30.63138523
96TTK0.62935621
97BRSK10.62105255
98FGFR20.62026896
99ATR0.61912643
100PKN10.60796566
101NEK60.60150282
102ADRBK10.58917697
103PRPF4B0.57232661
104RPS6KA20.56336832
105CAMKK10.56053296
106BRD40.54725507
107ATM0.54050889
108IRAK20.53785741
109CHEK20.53732217
110SGK10.52884843
111STK160.51264614
112LATS10.50013498
113ROCK10.49925944
114PINK10.49354419
115PRKACA0.48530611
116PIK3CA0.47657488
117BUB10.47436747
118PRKCH0.47323664
119DYRK1B0.47121515
120PDGFRA0.46795568
121MAP3K120.45822167
122TGFBR10.45815158
123PRKAA10.45551482
124CSNK1E0.44711879
125EPHB20.44371020
126CAMK10.44300547
127SIK20.41740530
128NTRK10.41095807
129RPS6KB10.41032605
130PRKG10.41010043
131ERBB20.40637116
132CSNK1A10.40580809
133CAMK40.40174836
134MARK20.38637278
135NME10.37978880
136TAF10.37686462
137CDK140.37021198
138CSNK1D0.36778188
139RPS6KA30.36752375
140CDK180.36278222
141DMPK0.35119733
142IRAK10.34841530
143OXSR10.34612878
144MET0.34362725
145SRPK10.33742063
146PRKACB0.32570798
147CSNK1G20.32363832
148PRKDC0.30504520

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.10140066
2Insulin secretion_Homo sapiens_hsa049112.76527835
3Nicotine addiction_Homo sapiens_hsa050332.62685953
4Synaptic vesicle cycle_Homo sapiens_hsa047212.49424134
5Fanconi anemia pathway_Homo sapiens_hsa034602.37000734
6Amphetamine addiction_Homo sapiens_hsa050312.23544154
7GABAergic synapse_Homo sapiens_hsa047272.14758083
8Taste transduction_Homo sapiens_hsa047422.13818038
9Circadian entrainment_Homo sapiens_hsa047132.13411309
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.12820137
11Homologous recombination_Homo sapiens_hsa034402.09635984
12Olfactory transduction_Homo sapiens_hsa047402.07944960
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07940195
14Phototransduction_Homo sapiens_hsa047442.03694195
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.03513149
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01896626
17Oxidative phosphorylation_Homo sapiens_hsa001901.97774376
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97034244
19Protein export_Homo sapiens_hsa030601.91568234
20Collecting duct acid secretion_Homo sapiens_hsa049661.89327023
21Morphine addiction_Homo sapiens_hsa050321.88973944
22Cardiac muscle contraction_Homo sapiens_hsa042601.88142519
23Vibrio cholerae infection_Homo sapiens_hsa051101.87523859
24Dopaminergic synapse_Homo sapiens_hsa047281.86423438
25Long-term potentiation_Homo sapiens_hsa047201.84347662
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83441092
27Non-homologous end-joining_Homo sapiens_hsa034501.76443983
28Glutamatergic synapse_Homo sapiens_hsa047241.71109517
29Cocaine addiction_Homo sapiens_hsa050301.69144848
30Serotonergic synapse_Homo sapiens_hsa047261.59491638
31Parkinsons disease_Homo sapiens_hsa050121.58932853
32Huntingtons disease_Homo sapiens_hsa050161.57716764
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56317074
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56272510
35Steroid biosynthesis_Homo sapiens_hsa001001.54793321
36Alzheimers disease_Homo sapiens_hsa050101.48857439
37Nitrogen metabolism_Homo sapiens_hsa009101.46962177
38Renin secretion_Homo sapiens_hsa049241.46497537
39Cholinergic synapse_Homo sapiens_hsa047251.44830650
40Linoleic acid metabolism_Homo sapiens_hsa005911.44337814
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42041637
42Circadian rhythm_Homo sapiens_hsa047101.41452225
43Type II diabetes mellitus_Homo sapiens_hsa049301.41178747
44Glucagon signaling pathway_Homo sapiens_hsa049221.38971169
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35175862
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32503731
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31345509
48RNA polymerase_Homo sapiens_hsa030201.29834069
49Dilated cardiomyopathy_Homo sapiens_hsa054141.27907874
50Gastric acid secretion_Homo sapiens_hsa049711.23166576
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21774542
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18537122
53Calcium signaling pathway_Homo sapiens_hsa040201.16335790
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13756239
55RNA degradation_Homo sapiens_hsa030181.13216354
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11797950
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08932176
58cAMP signaling pathway_Homo sapiens_hsa040241.07369540
59Tryptophan metabolism_Homo sapiens_hsa003801.07304293
60Salivary secretion_Homo sapiens_hsa049701.06756480
61Sulfur metabolism_Homo sapiens_hsa009201.06556430
62Nucleotide excision repair_Homo sapiens_hsa034201.06094863
63Oxytocin signaling pathway_Homo sapiens_hsa049211.05900102
64Ether lipid metabolism_Homo sapiens_hsa005651.04013951
65Mismatch repair_Homo sapiens_hsa034301.03832701
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98364160
67Long-term depression_Homo sapiens_hsa047300.97841476
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97199768
69Melanogenesis_Homo sapiens_hsa049160.97175736
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96107992
71Selenocompound metabolism_Homo sapiens_hsa004500.95867774
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94953928
73Peroxisome_Homo sapiens_hsa041460.93638676
74beta-Alanine metabolism_Homo sapiens_hsa004100.91683437
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.90185550
76Estrogen signaling pathway_Homo sapiens_hsa049150.90042104
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.89000316
78Gap junction_Homo sapiens_hsa045400.88754627
79Thyroid hormone synthesis_Homo sapiens_hsa049180.87577231
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85738105
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.84591234
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84253896
83Oocyte meiosis_Homo sapiens_hsa041140.84109375
84GnRH signaling pathway_Homo sapiens_hsa049120.84048315
85Dorso-ventral axis formation_Homo sapiens_hsa043200.82858531
86Hedgehog signaling pathway_Homo sapiens_hsa043400.82834888
87Chemical carcinogenesis_Homo sapiens_hsa052040.82825938
88Cell cycle_Homo sapiens_hsa041100.82699603
89RNA transport_Homo sapiens_hsa030130.81837123
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81756972
91Axon guidance_Homo sapiens_hsa043600.80979450
92Retinol metabolism_Homo sapiens_hsa008300.80075128
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80008797
94Alcoholism_Homo sapiens_hsa050340.78185837
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76207737
96Wnt signaling pathway_Homo sapiens_hsa043100.75852913
97Caffeine metabolism_Homo sapiens_hsa002320.75640502
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74557573
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74403689
100Pancreatic secretion_Homo sapiens_hsa049720.73437404
101Pyruvate metabolism_Homo sapiens_hsa006200.72102087
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71345093
103Lysine degradation_Homo sapiens_hsa003100.69196256
104Type I diabetes mellitus_Homo sapiens_hsa049400.67307442
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66585585
106ABC transporters_Homo sapiens_hsa020100.65175707
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64701614
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64496249
109Spliceosome_Homo sapiens_hsa030400.64415485
110Purine metabolism_Homo sapiens_hsa002300.64154412
111Fatty acid degradation_Homo sapiens_hsa000710.63673108
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62052919
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61640611
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61551617
115N-Glycan biosynthesis_Homo sapiens_hsa005100.61456594
116Metabolic pathways_Homo sapiens_hsa011000.61326169
117TGF-beta signaling pathway_Homo sapiens_hsa043500.59783762
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59686100
119Butanoate metabolism_Homo sapiens_hsa006500.58198222
120Insulin signaling pathway_Homo sapiens_hsa049100.58111659
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.57640506
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56972590
123Base excision repair_Homo sapiens_hsa034100.55804540
124Tight junction_Homo sapiens_hsa045300.54704962
125Fatty acid metabolism_Homo sapiens_hsa012120.52917805
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51965035
127Ovarian steroidogenesis_Homo sapiens_hsa049130.50325895
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50149642
129Glycerolipid metabolism_Homo sapiens_hsa005610.49730883
130Arginine and proline metabolism_Homo sapiens_hsa003300.49580073
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49231398
132ErbB signaling pathway_Homo sapiens_hsa040120.48995906
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48896845
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48810880
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48401702
136Fatty acid elongation_Homo sapiens_hsa000620.47598127
137Hippo signaling pathway_Homo sapiens_hsa043900.45598407
138Basal cell carcinoma_Homo sapiens_hsa052170.45431727
139Tyrosine metabolism_Homo sapiens_hsa003500.44128651
140Glioma_Homo sapiens_hsa052140.43522079
141Propanoate metabolism_Homo sapiens_hsa006400.42296755
142MAPK signaling pathway_Homo sapiens_hsa040100.41679550
143Endometrial cancer_Homo sapiens_hsa052130.40847515
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36298361
145mRNA surveillance pathway_Homo sapiens_hsa030150.36168986
146Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35530424
147Renal cell carcinoma_Homo sapiens_hsa052110.34047783
148AMPK signaling pathway_Homo sapiens_hsa041520.33085896
149Ras signaling pathway_Homo sapiens_hsa040140.32310644
150Insulin resistance_Homo sapiens_hsa049310.30290897
151Basal transcription factors_Homo sapiens_hsa030220.29870022
152Regulation of autophagy_Homo sapiens_hsa041400.28389238

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