IFT88

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.15193144
2axonemal dynein complex assembly (GO:0070286)6.71079630
3cilium movement (GO:0003341)6.43240679
4intraciliary transport (GO:0042073)6.09992580
5epithelial cilium movement (GO:0003351)5.92609957
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.70545175
7protein localization to cilium (GO:0061512)5.33440581
8fusion of sperm to egg plasma membrane (GO:0007342)5.02974706
9motile cilium assembly (GO:0044458)4.97798238
10piRNA metabolic process (GO:0034587)4.54502277
11male meiosis (GO:0007140)4.50881635
12* axoneme assembly (GO:0035082)4.38078603
13sperm motility (GO:0030317)4.26319890
14multicellular organism reproduction (GO:0032504)4.21847408
15acrosome reaction (GO:0007340)4.21768044
16regulation of cilium movement (GO:0003352)4.21299611
17cell wall macromolecule metabolic process (GO:0044036)4.18996381
18cell wall macromolecule catabolic process (GO:0016998)4.18996381
19cilium organization (GO:0044782)4.04916560
20cilium assembly (GO:0042384)4.02365121
21plasma membrane fusion (GO:0045026)4.01590814
22sperm-egg recognition (GO:0035036)3.95761253
23regulation of meiosis I (GO:0060631)3.86988476
24spermatid development (GO:0007286)3.80251301
25presynaptic membrane assembly (GO:0097105)3.76626556
26acrosome assembly (GO:0001675)3.74621424
27ventricular system development (GO:0021591)3.65593804
28DNA methylation involved in gamete generation (GO:0043046)3.65077151
29synapsis (GO:0007129)3.64151499
30calcium ion-dependent exocytosis (GO:0017156)3.62437570
31neural tube formation (GO:0001841)3.57017628
32* cilium morphogenesis (GO:0060271)3.53271281
33presynaptic membrane organization (GO:0097090)3.43610979
34lactate metabolic process (GO:0006089)3.41836725
35retinal cone cell development (GO:0046549)3.41129575
36cell-cell recognition (GO:0009988)3.39176730
37synaptonemal complex organization (GO:0070193)3.39075474
38response to pheromone (GO:0019236)3.38789946
39resolution of meiotic recombination intermediates (GO:0000712)3.38465476
40male meiosis I (GO:0007141)3.35870055
41binding of sperm to zona pellucida (GO:0007339)3.35633544
42protein polyglutamylation (GO:0018095)3.28219897
43* microtubule bundle formation (GO:0001578)3.27400218
44nonmotile primary cilium assembly (GO:0035058)3.23467249
45platelet dense granule organization (GO:0060155)3.17744172
46microtubule depolymerization (GO:0007019)3.16427675
47meiotic chromosome segregation (GO:0045132)3.14042901
48* cellular component assembly involved in morphogenesis (GO:0010927)3.13948789
49single fertilization (GO:0007338)3.11363207
50ER overload response (GO:0006983)3.01444429
51synaptonemal complex assembly (GO:0007130)3.00508778
52urinary tract smooth muscle contraction (GO:0014848)2.99758097
53tryptophan catabolic process (GO:0006569)2.99005712
54indole-containing compound catabolic process (GO:0042436)2.99005712
55indolalkylamine catabolic process (GO:0046218)2.99005712
56reproduction (GO:0000003)2.96895860
57retinal rod cell development (GO:0046548)2.96100787
58fucose catabolic process (GO:0019317)2.92621756
59L-fucose metabolic process (GO:0042354)2.92621756
60L-fucose catabolic process (GO:0042355)2.92621756
61detection of calcium ion (GO:0005513)2.92057196
62reciprocal meiotic recombination (GO:0007131)2.91370313
63reciprocal DNA recombination (GO:0035825)2.91370313
64centriole replication (GO:0007099)2.90700885
65* smoothened signaling pathway (GO:0007224)2.90290745
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.88885180
67cellular ketone body metabolic process (GO:0046950)2.88669423
68microtubule-based movement (GO:0007018)2.87943101
69photoreceptor cell maintenance (GO:0045494)2.81418278
70regulation of glucokinase activity (GO:0033131)2.81016481
71regulation of hexokinase activity (GO:1903299)2.81016481
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79430663
73DNA double-strand break processing (GO:0000729)2.78777289
74postsynaptic membrane organization (GO:0001941)2.77983102
75meiotic nuclear division (GO:0007126)2.77028305
76centriole assembly (GO:0098534)2.75841750
77signal peptide processing (GO:0006465)2.74187634
78GTP biosynthetic process (GO:0006183)2.72672356
79* cell projection assembly (GO:0030031)2.72550035
80protein neddylation (GO:0045116)2.72118461
81response to nitrosative stress (GO:0051409)2.71618179
82behavioral response to nicotine (GO:0035095)2.71522925
83regulation of synaptic vesicle exocytosis (GO:2000300)2.71345465
84limb bud formation (GO:0060174)2.70513367
85water-soluble vitamin biosynthetic process (GO:0042364)2.68809652
86Golgi transport vesicle coating (GO:0048200)2.68716525
87COPI coating of Golgi vesicle (GO:0048205)2.68716525
88photoreceptor cell development (GO:0042461)2.68326272
89* determination of left/right symmetry (GO:0007368)2.67729340
90left/right pattern formation (GO:0060972)2.65732521
91protein-cofactor linkage (GO:0018065)2.65615521
92cornea development in camera-type eye (GO:0061303)2.64168200
93preassembly of GPI anchor in ER membrane (GO:0016254)2.63292866
94meiosis I (GO:0007127)2.63086346
95microtubule polymerization or depolymerization (GO:0031109)2.62392361
96guanosine-containing compound biosynthetic process (GO:1901070)2.60110123
97neuron cell-cell adhesion (GO:0007158)2.59617989
98eye photoreceptor cell development (GO:0042462)2.59174284
99oxidative demethylation (GO:0070989)2.59092806
100ketone body metabolic process (GO:1902224)2.58612101
101regulation of type B pancreatic cell apoptotic process (GO:2000674)2.57269520
102* determination of bilateral symmetry (GO:0009855)2.56967117
103negative regulation of transcription regulatory region DNA binding (GO:2000678)2.55320678
104indolalkylamine metabolic process (GO:0006586)2.54829126
105brain morphogenesis (GO:0048854)2.53881117
106kynurenine metabolic process (GO:0070189)2.53745770
107intra-Golgi vesicle-mediated transport (GO:0006891)2.53602778
108pyrimidine dimer repair (GO:0006290)2.53301308
109* specification of symmetry (GO:0009799)2.51032296
110replication fork processing (GO:0031297)2.50459948
111positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.50436461
112detection of light stimulus involved in visual perception (GO:0050908)2.49943268
113detection of light stimulus involved in sensory perception (GO:0050962)2.49943268
114organelle disassembly (GO:1903008)2.48502441
115somite development (GO:0061053)2.48048989
116recombinational repair (GO:0000725)2.46583089
117double-strand break repair via homologous recombination (GO:0000724)2.46294759
118fertilization (GO:0009566)2.46289031
119regulation of microtubule-based movement (GO:0060632)2.46041730
120calcium ion import (GO:0070509)2.46027024
121nucleoside diphosphate phosphorylation (GO:0006165)2.45424773
122left/right axis specification (GO:0070986)2.44955666
123synaptic vesicle endocytosis (GO:0048488)2.44003905
124tryptophan metabolic process (GO:0006568)2.43663284
125exogenous drug catabolic process (GO:0042738)2.41487281
126synaptic vesicle docking involved in exocytosis (GO:0016081)2.41271543
127spinal cord motor neuron differentiation (GO:0021522)2.41117208
128hindbrain development (GO:0030902)2.40882764
129cullin deneddylation (GO:0010388)2.40184929
130intra-S DNA damage checkpoint (GO:0031573)2.40144084
131DNA integration (GO:0015074)2.39931219
132otic vesicle formation (GO:0030916)2.39276627
133respiratory chain complex IV assembly (GO:0008535)2.38976948
134limb development (GO:0060173)2.38808329
135appendage development (GO:0048736)2.38808329
136chromosome organization involved in meiosis (GO:0070192)2.38136980
137regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.38064962
138neuron fate determination (GO:0048664)2.37375786
139inositol phosphate catabolic process (GO:0071545)2.36353143
140regulation of male gonad development (GO:2000018)2.35707909
141regulation of synaptic vesicle transport (GO:1902803)2.35238919
142olfactory bulb development (GO:0021772)2.35133059
143positive regulation of oligodendrocyte differentiation (GO:0048714)2.34153550
144male gamete generation (GO:0048232)2.33684168
145lateral ventricle development (GO:0021670)2.33610165
146mannosylation (GO:0097502)2.33455679
147spermatogenesis (GO:0007283)2.33390204
148gamma-aminobutyric acid transport (GO:0015812)2.32660926
149regulation of timing of cell differentiation (GO:0048505)2.32616091
150C-terminal protein lipidation (GO:0006501)2.32258967
151startle response (GO:0001964)2.31410469
152inner ear receptor cell differentiation (GO:0060113)2.31003613
153sperm capacitation (GO:0048240)2.30678647
154insulin secretion (GO:0030073)2.30104619
155sensory perception of taste (GO:0050909)2.29794223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.29881962
2GBX2_23144817_ChIP-Seq_PC3_Human3.52862013
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.48547140
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.93036662
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.90196996
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.89844659
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47804079
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.42354499
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34855264
10FUS_26573619_Chip-Seq_HEK293_Human2.30671424
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14731720
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12368373
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.06991952
14TAF15_26573619_Chip-Seq_HEK293_Human2.05302321
15VDR_22108803_ChIP-Seq_LS180_Human1.99221612
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98914491
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98813192
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98498295
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98059322
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95740603
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93290745
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93082897
23SMAD4_21799915_ChIP-Seq_A2780_Human1.80698812
24RNF2_27304074_Chip-Seq_NSC_Mouse1.79891849
25TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.76460520
26P300_19829295_ChIP-Seq_ESCs_Human1.75090735
27MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73819067
28NANOG_18555785_Chip-Seq_ESCs_Mouse1.73700821
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70164273
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69922347
31EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.67510675
32P53_22387025_ChIP-Seq_ESCs_Mouse1.64152709
33IGF1R_20145208_ChIP-Seq_DFB_Human1.63493435
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.63097110
35BCAT_22108803_ChIP-Seq_LS180_Human1.62889959
36REST_21632747_ChIP-Seq_MESCs_Mouse1.60743656
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55919207
38ZNF274_21170338_ChIP-Seq_K562_Hela1.51926989
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51063111
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49849616
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.49381938
42STAT3_23295773_ChIP-Seq_U87_Human1.47926939
43E2F1_18555785_Chip-Seq_ESCs_Mouse1.47493434
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46864441
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46250989
46ELK1_19687146_ChIP-ChIP_HELA_Human1.46144782
47ER_23166858_ChIP-Seq_MCF-7_Human1.45912179
48TCF4_23295773_ChIP-Seq_U87_Human1.45809768
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.45784470
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45606777
51EWS_26573619_Chip-Seq_HEK293_Human1.45456488
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45003330
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.44834944
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44826121
55STAT3_18555785_Chip-Seq_ESCs_Mouse1.43365630
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38904209
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38284930
58SUZ12_18555785_Chip-Seq_ESCs_Mouse1.37361345
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36051272
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36051272
61TP53_22573176_ChIP-Seq_HFKS_Human1.35816825
62CMYC_18555785_Chip-Seq_ESCs_Mouse1.35621707
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.34986589
64P300_18555785_Chip-Seq_ESCs_Mouse1.33786675
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.32904833
66IRF1_19129219_ChIP-ChIP_H3396_Human1.32420976
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31119231
68SOX2_18555785_Chip-Seq_ESCs_Mouse1.30672200
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.30288346
70EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29827539
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.29754007
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29619153
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29601867
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27431512
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27335036
76NANOG_19829295_ChIP-Seq_ESCs_Human1.25807268
77SOX2_19829295_ChIP-Seq_ESCs_Human1.25807268
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24977535
79SOX9_26525672_Chip-Seq_HEART_Mouse1.22734205
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22487254
81FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20503431
82AR_21572438_ChIP-Seq_LNCaP_Human1.20467142
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20368673
84NMYC_18555785_Chip-Seq_ESCs_Mouse1.19967574
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19814841
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.19814841
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19608259
88RUNX1_27457419_Chip-Seq_LIVER_Mouse1.19273086
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19115385
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18842775
91CBP_20019798_ChIP-Seq_JUKART_Human1.18370785
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18370785
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.17259783
94OCT4_18555785_Chip-Seq_ESCs_Mouse1.17122230
95FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16247705
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15111050
97AR_25329375_ChIP-Seq_VCAP_Human1.14793918
98KDM2B_26808549_Chip-Seq_REH_Human1.14706331
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14126028
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13634184
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12751108
102CDX2_22108803_ChIP-Seq_LS180_Human1.12456139
103MYC_18940864_ChIP-ChIP_HL60_Human1.12076486
104CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11880747
105ZFX_18555785_Chip-Seq_ESCs_Mouse1.11764226
106EZH2_27304074_Chip-Seq_ESCs_Mouse1.11067509
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10550257
108EST1_17652178_ChIP-ChIP_JURKAT_Human1.10429446
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10255715
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.10072296
111KLF4_18555785_Chip-Seq_ESCs_Mouse1.09983222
112* RUNX2_22187159_ChIP-Seq_PCA_Human1.09076277
113TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07801424
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06558765
115SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06339882
116ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06251694
117PU1_27457419_Chip-Seq_LIVER_Mouse1.05757128
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.04964099
119AR_20517297_ChIP-Seq_VCAP_Human1.03796356
120CTCF_18555785_Chip-Seq_ESCs_Mouse1.02967554
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01835077
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01704084
123ARNT_22903824_ChIP-Seq_MCF-7_Human1.01253254
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00987242
125POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00690573
126TCF4_22108803_ChIP-Seq_LS180_Human0.99518246
127SOX2_21211035_ChIP-Seq_LN229_Gbm0.98535405
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98232433
129JUN_21703547_ChIP-Seq_K562_Human0.97174358

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.32639128
2MP0003787_abnormal_imprinting3.30166147
3MP0005410_abnormal_fertilization3.29457610
4MP0001984_abnormal_olfaction3.21055757
5MP0001188_hyperpigmentation3.13007384
6MP0000569_abnormal_digit_pigmentation3.06773421
7MP0005646_abnormal_pituitary_gland2.55607369
8MP0003136_yellow_coat_color2.32694996
9MP0005645_abnormal_hypothalamus_physiol2.27302523
10MP0010386_abnormal_urinary_bladder2.23462210
11MP0003122_maternal_imprinting2.22687165
12MP0006276_abnormal_autonomic_nervous2.22389367
13MP0003880_abnormal_central_pattern2.21690165
14MP0008875_abnormal_xenobiotic_pharmacok2.13972620
15MP0006072_abnormal_retinal_apoptosis2.03272448
16MP0000383_abnormal_hair_follicle1.98859673
17MP0003698_abnormal_male_reproductive1.97741226
18MP0005551_abnormal_eye_electrophysiolog1.97508318
19MP0003121_genomic_imprinting1.97188729
20MP0003195_calcinosis1.95640794
21MP0002160_abnormal_reproductive_system1.94075414
22MP0006292_abnormal_olfactory_placode1.88196393
23MP0002876_abnormal_thyroid_physiology1.87793578
24MP0008789_abnormal_olfactory_epithelium1.86116938
25MP0002638_abnormal_pupillary_reflex1.85710504
26MP0005394_taste/olfaction_phenotype1.85141118
27MP0005499_abnormal_olfactory_system1.85141118
28MP0002102_abnormal_ear_morphology1.84940307
29MP0001929_abnormal_gametogenesis1.75266302
30MP0008058_abnormal_DNA_repair1.75181406
31MP0009697_abnormal_copulation1.74126300
32MP0002282_abnormal_trachea_morphology1.72590153
33MP0005379_endocrine/exocrine_gland_phen1.70222414
34MP0000427_abnormal_hair_cycle1.67931100
35MP0002938_white_spotting1.65200852
36MP0004270_analgesia1.64583044
37MP0002653_abnormal_ependyma_morphology1.62499349
38MP0003890_abnormal_embryonic-extraembry1.61776963
39MP0002734_abnormal_mechanical_nocicepti1.60467908
40MP0002210_abnormal_sex_determination1.52674592
41MP0001986_abnormal_taste_sensitivity1.52551823
42MP0001502_abnormal_circadian_rhythm1.49223428
43MP0000631_abnormal_neuroendocrine_gland1.40819100
44MP0002735_abnormal_chemical_nociception1.40246357
45MP0003635_abnormal_synaptic_transmissio1.39926338
46MP0005253_abnormal_eye_physiology1.39607760
47MP0002233_abnormal_nose_morphology1.36235383
48MP0005084_abnormal_gallbladder_morpholo1.33331363
49MP0008995_early_reproductive_senescence1.32357565
50MP0002837_dystrophic_cardiac_calcinosis1.32051733
51MP0002572_abnormal_emotion/affect_behav1.31544411
52MP0003879_abnormal_hair_cell1.31512087
53MP0005389_reproductive_system_phenotype1.31461995
54MP0000647_abnormal_sebaceous_gland1.31400551
55MP0010678_abnormal_skin_adnexa1.30164448
56MP0002163_abnormal_gland_morphology1.29248026
57MP0002909_abnormal_adrenal_gland1.29168915
58MP0001293_anophthalmia1.29021465
59MP0002234_abnormal_pharynx_morphology1.27572388
60MP0000778_abnormal_nervous_system1.27488231
61* MP0003937_abnormal_limbs/digits/tail_de1.27398613
62MP0002184_abnormal_innervation1.26237011
63MP0009780_abnormal_chondrocyte_physiolo1.25690846
64MP0002272_abnormal_nervous_system1.25514002
65MP0003123_paternal_imprinting1.24762248
66MP0002557_abnormal_social/conspecific_i1.24177161
67MP0009745_abnormal_behavioral_response1.23591844
68MP0003718_maternal_effect1.23325022
69MP0005195_abnormal_posterior_eye1.22952868
70MP0002063_abnormal_learning/memory/cond1.20569434
71MP0009046_muscle_twitch1.19950402
72MP0000678_abnormal_parathyroid_gland1.18706771
73MP0003011_delayed_dark_adaptation1.18494874
74MP0008872_abnormal_physiological_respon1.15772434
75MP0001145_abnormal_male_reproductive1.14926705
76MP0008004_abnormal_stomach_pH1.13702371
77MP0003183_abnormal_peptide_metabolism1.13075264
78MP0005248_abnormal_Harderian_gland1.12727355
79MP0002751_abnormal_autonomic_nervous1.12406917
80MP0008007_abnormal_cellular_replicative1.12114746
81MP0000653_abnormal_sex_gland1.10396504
82* MP0002693_abnormal_pancreas_physiology1.09965805
83MP0002067_abnormal_sensory_capabilities1.08678650
84MP0001968_abnormal_touch/_nociception1.08629358
85MP0005391_vision/eye_phenotype1.07902176
86MP0008057_abnormal_DNA_replication1.05648994
87MP0004859_abnormal_synaptic_plasticity1.04499128
88MP0005423_abnormal_somatic_nervous1.04051518
89MP0001905_abnormal_dopamine_level1.03972877
90MP0000372_irregular_coat_pigmentation1.03711447
91MP0001486_abnormal_startle_reflex1.03409119
92MP0004043_abnormal_pH_regulation1.03356205
93MP0005187_abnormal_penis_morphology1.01319471
94* MP0001944_abnormal_pancreas_morphology1.01129547
95MP0001963_abnormal_hearing_physiology1.00867938
96MP0004147_increased_porphyrin_level1.00123058
97MP0001270_distended_abdomen0.99577064
98MP0004215_abnormal_myocardial_fiber0.98958294
99MP0002161_abnormal_fertility/fecundity0.98581848
100MP0004142_abnormal_muscle_tone0.98552527
101MP0004133_heterotaxia0.98031333
102MP0002064_seizures0.97702939
103MP0002132_abnormal_respiratory_system0.97617544
104MP0005085_abnormal_gallbladder_physiolo0.96921829
105MP0003786_premature_aging0.96868033
106MP0001485_abnormal_pinna_reflex0.94890420
107MP0003252_abnormal_bile_duct0.92995926
108MP0010329_abnormal_lipoprotein_level0.92831007
109MP0002882_abnormal_neuron_morphology0.92221081
110MP0000049_abnormal_middle_ear0.90796984
111MP0004134_abnormal_chest_morphology0.90233313
112MP0003938_abnormal_ear_development0.89617030
113MP0006054_spinal_hemorrhage0.88382875
114MP0002752_abnormal_somatic_nervous0.88166142
115MP0002277_abnormal_respiratory_mucosa0.88074788
116MP0001764_abnormal_homeostasis0.86438669
117* MP0000026_abnormal_inner_ear0.84739550
118MP0005386_behavior/neurological_phenoty0.84293387
119MP0004811_abnormal_neuron_physiology0.83926374
120MP0001529_abnormal_vocalization0.83001198
121MP0000955_abnormal_spinal_cord0.82918353
122MP0004742_abnormal_vestibular_system0.82714774
123MP0003942_abnormal_urinary_system0.82361380
124MP0004264_abnormal_extraembryonic_tissu0.81923982
125MP0000613_abnormal_salivary_gland0.81529573
126MP0001177_atelectasis0.80783878
127* MP0001286_abnormal_eye_development0.80209584
128MP0002736_abnormal_nociception_after0.79523628
129MP0003943_abnormal_hepatobiliary_system0.79411671
130MP0001324_abnormal_eye_pigmentation0.78833760
131MP0003878_abnormal_ear_physiology0.78674082
132MP0005377_hearing/vestibular/ear_phenot0.78674082
133MP0004885_abnormal_endolymph0.78549515
134* MP0002928_abnormal_bile_duct0.78190258
135MP0002229_neurodegeneration0.77043220
136MP0000013_abnormal_adipose_tissue0.76989353
137MP0004924_abnormal_behavior0.76398403

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.17788425
2Abnormal respiratory motile cilium physiology (HP:0012261)6.30907566
3Abnormal ciliary motility (HP:0012262)5.89524219
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.50897264
5Absent/shortened dynein arms (HP:0200106)5.50897264
6Rhinitis (HP:0012384)5.11159233
7Abnormal respiratory motile cilium morphology (HP:0005938)5.07718861
8Abnormal respiratory epithelium morphology (HP:0012253)5.07718861
9Chronic bronchitis (HP:0004469)4.76720705
10True hermaphroditism (HP:0010459)4.15591797
11Pancreatic fibrosis (HP:0100732)3.91112774
12Medial flaring of the eyebrow (HP:0010747)3.91091441
13Abnormality of midbrain morphology (HP:0002418)3.71169907
14Molar tooth sign on MRI (HP:0002419)3.71169907
15Nephronophthisis (HP:0000090)3.54352219
16Tubulointerstitial nephritis (HP:0001970)3.50856304
17Gait imbalance (HP:0002141)3.45827787
18Congenital primary aphakia (HP:0007707)3.43282442
19Nephrogenic diabetes insipidus (HP:0009806)3.33848922
20Pancreatic cysts (HP:0001737)3.11773170
21Chronic hepatic failure (HP:0100626)3.11293963
22Hypothermia (HP:0002045)3.06789948
23Abnormality of the renal medulla (HP:0100957)3.00202186
24Tubular atrophy (HP:0000092)2.96538577
25Occipital encephalocele (HP:0002085)2.95992221
26Bronchiectasis (HP:0002110)2.89314626
27Poor coordination (HP:0002370)2.89129433
28Papillary thyroid carcinoma (HP:0002895)2.85935407
29Fibular hypoplasia (HP:0003038)2.81187816
30Cystic liver disease (HP:0006706)2.77628387
31Genital tract atresia (HP:0001827)2.73641195
32Vaginal atresia (HP:0000148)2.68122355
33Epileptic encephalopathy (HP:0200134)2.63745829
34Median cleft lip (HP:0000161)2.57800787
35Postaxial foot polydactyly (HP:0001830)2.53599817
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.53534153
37Absent eyebrow (HP:0002223)2.50443466
38Volvulus (HP:0002580)2.49306049
39Bifid tongue (HP:0010297)2.48430300
40Facial cleft (HP:0002006)2.46136276
41Febrile seizures (HP:0002373)2.43918694
42Intestinal atresia (HP:0011100)2.43561257
43Infertility (HP:0000789)2.33332695
44Aplasia/Hypoplasia of the lens (HP:0008063)2.31805208
45Abnormal biliary tract physiology (HP:0012439)2.29646388
46Bile duct proliferation (HP:0001408)2.29646388
47Congenital hepatic fibrosis (HP:0002612)2.25643783
48Postaxial hand polydactyly (HP:0001162)2.25484989
49Abnormal hair whorl (HP:0010721)2.22477335
5011 pairs of ribs (HP:0000878)2.21200382
51Colon cancer (HP:0003003)2.18464765
52Polydipsia (HP:0001959)2.18101212
53Abnormal drinking behavior (HP:0030082)2.18101212
54Hyperglycinemia (HP:0002154)2.12363047
55Abnormality of macular pigmentation (HP:0008002)2.08893987
56Hepatoblastoma (HP:0002884)2.08776385
57Bronchitis (HP:0012387)2.06220757
58Preaxial hand polydactyly (HP:0001177)2.06053164
59Bony spicule pigmentary retinopathy (HP:0007737)2.05950649
60Protruding tongue (HP:0010808)2.04020101
61Thyroid carcinoma (HP:0002890)2.03133223
62Furrowed tongue (HP:0000221)2.01697649
63Atonic seizures (HP:0010819)2.01513381
64Oligodactyly (hands) (HP:0001180)2.01019437
65Male pseudohermaphroditism (HP:0000037)1.98895375
66Type II lissencephaly (HP:0007260)1.95570221
67Hyperglycinuria (HP:0003108)1.93692520
68Abnormality of the labia minora (HP:0012880)1.93088505
69Abolished electroretinogram (ERG) (HP:0000550)1.92810366
70Congenital stationary night blindness (HP:0007642)1.92131575
71Rhabdomyosarcoma (HP:0002859)1.89331374
72Abnormal rod and cone electroretinograms (HP:0008323)1.86577186
73Prominent nasal bridge (HP:0000426)1.85965173
74Renal dysplasia (HP:0000110)1.85116626
75Oculomotor apraxia (HP:0000657)1.84008185
76Focal motor seizures (HP:0011153)1.83059847
77Abnormality of the renal cortex (HP:0011035)1.82973709
78Aplasia/Hypoplasia of the spleen (HP:0010451)1.82944888
79Acute encephalopathy (HP:0006846)1.81977309
80Polyuria (HP:0000103)1.80470451
81Neoplasm of the adrenal cortex (HP:0100641)1.80466795
82Enlarged kidneys (HP:0000105)1.80091985
83Renal cortical cysts (HP:0000803)1.79928991
84Tubulointerstitial abnormality (HP:0001969)1.79766431
85Multicystic kidney dysplasia (HP:0000003)1.78499490
86Acute necrotizing encephalopathy (HP:0006965)1.78436027
87Gastrointestinal atresia (HP:0002589)1.78383779
88Anencephaly (HP:0002323)1.78126013
89Decreased circulating renin level (HP:0003351)1.75452995
90Severe visual impairment (HP:0001141)1.74652642
91Neonatal hypoglycemia (HP:0001998)1.74217297
92Asplenia (HP:0001746)1.74143334
93Epileptiform EEG discharges (HP:0011182)1.72551241
94Broad foot (HP:0001769)1.71041045
95Narrow forehead (HP:0000341)1.70749967
96Abnormal pancreas size (HP:0012094)1.70153876
97Sclerocornea (HP:0000647)1.70117957
98Aplasia/Hypoplasia of the fibula (HP:0006492)1.69367457
99Recurrent sinusitis (HP:0011108)1.69100045
100Abnormality of serine family amino acid metabolism (HP:0010894)1.68725267
101Abnormality of glycine metabolism (HP:0010895)1.68725267
102Sloping forehead (HP:0000340)1.67794899
103Hyperventilation (HP:0002883)1.67395930
104Short tibia (HP:0005736)1.66993673
105Retinitis pigmentosa (HP:0000510)1.66757371
106Progressive cerebellar ataxia (HP:0002073)1.66386566
107Type I transferrin isoform profile (HP:0003642)1.66211718
108Nasal polyposis (HP:0100582)1.66047981
109Tubulointerstitial fibrosis (HP:0005576)1.65846776
110Aplasia/Hypoplasia of the uvula (HP:0010293)1.65520822
111Retinal dysplasia (HP:0007973)1.65447395
112Optic nerve hypoplasia (HP:0000609)1.65017904
113Dandy-Walker malformation (HP:0001305)1.64725539
114Aplasia/Hypoplasia of the tibia (HP:0005772)1.64246502
115Decreased central vision (HP:0007663)1.63685113
116Decreased testicular size (HP:0008734)1.63593308
117EEG with generalized epileptiform discharges (HP:0011198)1.63405136
118Anophthalmia (HP:0000528)1.61575607
119Vitreoretinal degeneration (HP:0000655)1.61464706
120Attenuation of retinal blood vessels (HP:0007843)1.59694959
121Small hand (HP:0200055)1.59569546
122Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.59172222
123Aganglionic megacolon (HP:0002251)1.58250612
124Central scotoma (HP:0000603)1.57453253
125Symptomatic seizures (HP:0011145)1.57426259
126Chronic sinusitis (HP:0011109)1.55336284
127Abnormality of the fovea (HP:0000493)1.55123102
128Supernumerary spleens (HP:0009799)1.52705488
129Absent rod-and cone-mediated responses on ERG (HP:0007688)1.52033644
130Bell-shaped thorax (HP:0001591)1.51188642
131Specific learning disability (HP:0001328)1.51188329
132Congenital sensorineural hearing impairment (HP:0008527)1.50261030
133Astigmatism (HP:0000483)1.49169288
134Gaze-evoked nystagmus (HP:0000640)1.48993933
135Short foot (HP:0001773)1.47675348
136Hypoplasia of the fovea (HP:0007750)1.47216858
137Aplasia/Hypoplasia of the fovea (HP:0008060)1.47216858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K73.06685876
2CASK3.06556379
3MAP4K23.04228163
4PASK2.81660123
5AKT32.75535682
6INSRR2.66618790
7NLK2.61451452
8TNIK2.53551979
9PDK42.49361494
10PDK32.49361494
11MAPK152.47110512
12ERBB32.38230524
13STK162.38193299
14FRK2.12333290
15MAP3K42.10728351
16NTRK32.06049651
17PNCK1.94291241
18BMPR1B1.89951926
19SIK31.88463504
20BCR1.87817345
21CDK191.87297471
22PRPF4B1.81004044
23MAPK131.77055300
24CCNB11.67664666
25PLK21.59989103
26SGK21.50744340
27STK38L1.50036530
28WNK31.45859755
29TRIM281.45515288
30MAP3K121.43351817
31CDK31.42432967
32WNK41.40175857
33BMPR21.35088079
34CSNK1G11.33557217
35PDK21.33325358
36PRKD31.31868193
37ACVR1B1.31715268
38MKNK21.25422080
39EPHA41.24381093
40GRK11.23940422
41PLK31.22757359
42WEE11.22203079
43MKNK11.18338599
44BRD41.17390971
45DAPK21.17352712
46SGK4941.13248707
47SGK2231.13248707
48SRPK11.11285341
49PAK31.09765257
50VRK11.08353359
51TAOK31.03923869
52IRAK10.96467303
53STK30.95866918
54DAPK10.91642248
55ZAK0.90158597
56PLK40.88908089
57NEK10.88035059
58DYRK1A0.87939250
59NEK20.87812889
60MARK10.87718860
61YES10.83508841
62FGFR20.82397141
63MINK10.81671250
64BRAF0.80436277
65PRKCG0.80193447
66NUAK10.78312303
67RPS6KB10.73902793
68CSNK1G20.69179080
69EPHB20.68011471
70FER0.67731617
71PTK2B0.67642001
72NEK60.66305686
73PLK10.66088071
74CDC70.65681366
75MAP2K40.65403176
76DYRK30.65045947
77NME10.64846342
78EPHA30.64514195
79PRKCE0.64140210
80ATR0.61246997
81TTK0.61041020
82TGFBR10.59800658
83DYRK20.59325904
84PINK10.58747759
85CDK80.57679636
86HIPK20.57355591
87PKN10.57163752
88EIF2AK30.56628955
89TSSK60.56340145
90GRK50.55968330
91SGK30.55719444
92GRK70.54977043
93WNK10.54925779
94IRAK20.54619283
95STK240.52990171
96RPS6KA40.52192084
97OXSR10.51323185
98ATM0.51057660
99CAMK2A0.50982182
100PIK3CA0.48902033
101RPS6KA20.48901582
102KSR10.48356393
103CAMK2B0.47866956
104MAP3K20.47612593
105STK390.47325199
106CAMKK20.46645815
107CAMK2D0.46342993
108CHEK10.45512780
109MAPKAPK30.44367722
110NTRK20.43898604
111ADRBK10.43828421
112ERBB20.43767120
113ADRBK20.43625793
114CSNK1G30.43181480
115MUSK0.42092028
116PRKG10.41633218
117TEC0.40238531
118BRSK20.38565245
119MST40.37452527
120CSNK1A10.36820144
121BCKDK0.35703929
122CSNK1A1L0.35469635
123PRKG20.35275055
124CAMK10.35129352
125EIF2AK10.34954378
126PRKCI0.34320675
127PRKACA0.34126535
128GSK3B0.33422415
129SGK10.33214974
130MAPK70.33111131
131PHKG20.32406303
132PHKG10.32406303
133CHEK20.32307556
134CDK50.32298677
135CAMK1G0.32028884
136CAMK2G0.31976250

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.47252532
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.28016989
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.24021932
4Nicotine addiction_Homo sapiens_hsa050332.88668191
5Phototransduction_Homo sapiens_hsa047442.64809850
6Insulin secretion_Homo sapiens_hsa049112.59419612
7Synaptic vesicle cycle_Homo sapiens_hsa047212.52472363
8Olfactory transduction_Homo sapiens_hsa047402.44244946
9Butanoate metabolism_Homo sapiens_hsa006502.42894933
10Propanoate metabolism_Homo sapiens_hsa006402.39696828
11Linoleic acid metabolism_Homo sapiens_hsa005912.26278863
12Collecting duct acid secretion_Homo sapiens_hsa049662.19874194
13Taste transduction_Homo sapiens_hsa047422.18737293
14Vibrio cholerae infection_Homo sapiens_hsa051102.11005268
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07160823
16Caffeine metabolism_Homo sapiens_hsa002322.06326314
17Amphetamine addiction_Homo sapiens_hsa050312.03611548
18Circadian entrainment_Homo sapiens_hsa047131.97623170
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94245744
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93925752
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91050092
22Chemical carcinogenesis_Homo sapiens_hsa052041.89603811
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.88781341
24Nitrogen metabolism_Homo sapiens_hsa009101.86216108
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85520182
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84078720
27Basal transcription factors_Homo sapiens_hsa030221.79771074
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.76069154
29Morphine addiction_Homo sapiens_hsa050321.69955252
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67007394
31beta-Alanine metabolism_Homo sapiens_hsa004101.64427429
32Non-homologous end-joining_Homo sapiens_hsa034501.61262979
33Tryptophan metabolism_Homo sapiens_hsa003801.61004843
34Dopaminergic synapse_Homo sapiens_hsa047281.59454445
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.58224423
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57424320
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55036568
38Steroid biosynthesis_Homo sapiens_hsa001001.54962639
39GABAergic synapse_Homo sapiens_hsa047271.54278931
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53074439
41Serotonergic synapse_Homo sapiens_hsa047261.52846252
42Retinol metabolism_Homo sapiens_hsa008301.51557571
43Ether lipid metabolism_Homo sapiens_hsa005651.49523977
44Peroxisome_Homo sapiens_hsa041461.48260810
45N-Glycan biosynthesis_Homo sapiens_hsa005101.48004154
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47203635
47Cocaine addiction_Homo sapiens_hsa050301.46833698
48Fanconi anemia pathway_Homo sapiens_hsa034601.45124394
49Histidine metabolism_Homo sapiens_hsa003401.44774929
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.43706101
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41505501
52Long-term potentiation_Homo sapiens_hsa047201.39068754
53Glutamatergic synapse_Homo sapiens_hsa047241.37997050
54Circadian rhythm_Homo sapiens_hsa047101.35181771
55Sulfur metabolism_Homo sapiens_hsa009201.31439183
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30349296
57Huntingtons disease_Homo sapiens_hsa050161.24280593
58Renin secretion_Homo sapiens_hsa049241.23134114
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19489658
60ABC transporters_Homo sapiens_hsa020101.15793370
61Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12798799
62Cholinergic synapse_Homo sapiens_hsa047251.12692178
63Fatty acid degradation_Homo sapiens_hsa000711.12461074
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10966785
65RNA degradation_Homo sapiens_hsa030181.05468503
66Purine metabolism_Homo sapiens_hsa002301.03932464
67Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03637630
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00864881
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00749963
70Glucagon signaling pathway_Homo sapiens_hsa049221.00568013
71Mismatch repair_Homo sapiens_hsa034300.97915989
72RNA polymerase_Homo sapiens_hsa030200.97283421
73Glutathione metabolism_Homo sapiens_hsa004800.96729919
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96728644
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94424358
76Salivary secretion_Homo sapiens_hsa049700.93048258
77Alcoholism_Homo sapiens_hsa050340.92946084
78Oocyte meiosis_Homo sapiens_hsa041140.92174690
79Calcium signaling pathway_Homo sapiens_hsa040200.91796212
80Type I diabetes mellitus_Homo sapiens_hsa049400.88447313
81Long-term depression_Homo sapiens_hsa047300.86951246
82Oxidative phosphorylation_Homo sapiens_hsa001900.86417030
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85084565
84Regulation of autophagy_Homo sapiens_hsa041400.84938400
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84722228
86mRNA surveillance pathway_Homo sapiens_hsa030150.83066905
87Arachidonic acid metabolism_Homo sapiens_hsa005900.82394872
88Thyroid hormone synthesis_Homo sapiens_hsa049180.82160033
89Homologous recombination_Homo sapiens_hsa034400.81325013
90Proteasome_Homo sapiens_hsa030500.80419151
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.78141468
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77309402
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76317415
94Sphingolipid metabolism_Homo sapiens_hsa006000.75329636
95cAMP signaling pathway_Homo sapiens_hsa040240.75157172
96Fat digestion and absorption_Homo sapiens_hsa049750.72944308
97Glycerolipid metabolism_Homo sapiens_hsa005610.72893027
98Fatty acid metabolism_Homo sapiens_hsa012120.71883203
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71551549
100Tyrosine metabolism_Homo sapiens_hsa003500.71444951
101Metabolic pathways_Homo sapiens_hsa011000.70999624
102Oxytocin signaling pathway_Homo sapiens_hsa049210.69132237
103Inositol phosphate metabolism_Homo sapiens_hsa005620.68770833
104Wnt signaling pathway_Homo sapiens_hsa043100.67638310
105Fatty acid elongation_Homo sapiens_hsa000620.67090394
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66471144
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65617237
108Melanogenesis_Homo sapiens_hsa049160.64771050
109RNA transport_Homo sapiens_hsa030130.64235899
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62392924
111Hedgehog signaling pathway_Homo sapiens_hsa043400.57424422
112Pyrimidine metabolism_Homo sapiens_hsa002400.57302265
113Phagosome_Homo sapiens_hsa041450.56621828
114One carbon pool by folate_Homo sapiens_hsa006700.56150438
115Base excision repair_Homo sapiens_hsa034100.56061981
116Type II diabetes mellitus_Homo sapiens_hsa049300.55642764
117Alzheimers disease_Homo sapiens_hsa050100.54382370
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53748319
119Selenocompound metabolism_Homo sapiens_hsa004500.53393912
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52881861
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.52649351
122Lysine degradation_Homo sapiens_hsa003100.51434929
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50506898
124Gastric acid secretion_Homo sapiens_hsa049710.50283158
125Pyruvate metabolism_Homo sapiens_hsa006200.50027543
126Estrogen signaling pathway_Homo sapiens_hsa049150.48896482
127Rheumatoid arthritis_Homo sapiens_hsa053230.48612562
128Cardiac muscle contraction_Homo sapiens_hsa042600.47084127
129Spliceosome_Homo sapiens_hsa030400.46764014
130Dorso-ventral axis formation_Homo sapiens_hsa043200.46121075
131Axon guidance_Homo sapiens_hsa043600.46087507
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44473220
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44017254
134Vitamin B6 metabolism_Homo sapiens_hsa007500.43466074
135Hippo signaling pathway_Homo sapiens_hsa043900.40241301
136Parkinsons disease_Homo sapiens_hsa050120.39937006
137Cell cycle_Homo sapiens_hsa041100.38862684
138Nucleotide excision repair_Homo sapiens_hsa034200.37661191
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37265168
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37121036
141Gap junction_Homo sapiens_hsa045400.36639451
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.36259417
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35402282
144TGF-beta signaling pathway_Homo sapiens_hsa043500.35285582
145Arginine and proline metabolism_Homo sapiens_hsa003300.35154414
146Basal cell carcinoma_Homo sapiens_hsa052170.34723713
147GnRH signaling pathway_Homo sapiens_hsa049120.32413864
148Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31899135
149Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30841834
150Phenylalanine metabolism_Homo sapiens_hsa003600.30496389
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27626101
152Ovarian steroidogenesis_Homo sapiens_hsa049130.27325300

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