ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	opioid receptor signaling pathway (GO:0038003)	5.34380239
2	leukotriene biosynthetic process (GO:0019370)	5.09100859
3	DNA deamination (GO:0045006)	4.71646272
4	cysteine metabolic process (GO:0006534)	4.34689246
5	protein-cofactor linkage (GO:0018065)	4.25972711
6	dentate gyrus development (GO:0021542)	4.17834564
7	dopaminergic neuron differentiation (GO:0071542)	4.16858102
8	centriole replication (GO:0007099)	4.00389170
9	purine nucleotide salvage (GO:0032261)	3.99367806
10	nucleoside diphosphate catabolic process (GO:0009134)	3.97621593
11	viral mRNA export from host cell nucleus (GO:0046784)	3.92857297
12	DNA strand renaturation (GO:0000733)	3.85480193
13	GPI anchor biosynthetic process (GO:0006506)	3.79709531
14	DNA double-strand break processing (GO:0000729)	3.74874664
15	cytidine deamination (GO:0009972)	3.72578601
16	cytidine metabolic process (GO:0046087)	3.72578601
17	cytidine catabolic process (GO:0006216)	3.72578601
18	leukotriene metabolic process (GO:0006691)	3.66267754
19	cellular ketone body metabolic process (GO:0046950)	3.63734131
20	replication fork processing (GO:0031297)	3.59415885
21	GPI anchor metabolic process (GO:0006505)	3.54970710
22	sequestering of actin monomers (GO:0042989)	3.48363055
23	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.46196216
24	regulation of mesenchymal cell apoptotic process (GO:2001053)	3.39690472
25	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.38926188
26	dendritic spine morphogenesis (GO:0060997)	3.38055365
27	neural tube formation (GO:0001841)	3.25489653
28	replicative senescence (GO:0090399)	3.24624234
29	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.23159049
30	ubiquinone metabolic process (GO:0006743)	3.22401243
31	somite development (GO:0061053)	3.21379152
32	ketone body metabolic process (GO:1902224)	3.20109647
33	protein complex biogenesis (GO:0070271)	3.19619711
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.19105465
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.19105465
36	NADH dehydrogenase complex assembly (GO:0010257)	3.19105465
37	centriole assembly (GO:0098534)	3.13318953
38	prostate gland growth (GO:0060736)	3.13291711
39	purine-containing compound salvage (GO:0043101)	3.11875283
40	negative T cell selection (GO:0043383)	3.10405444
41	regulation of pigment cell differentiation (GO:0050932)	3.09236665
42	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.06208152
43	phosphorelay signal transduction system (GO:0000160)	3.04795972
44	negative thymic T cell selection (GO:0045060)	3.04738591
45	L-fucose catabolic process (GO:0042355)	2.99545879
46	fucose catabolic process (GO:0019317)	2.99545879
47	L-fucose metabolic process (GO:0042354)	2.99545879
48	otic vesicle formation (GO:0030916)	2.97170375
49	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.96491401
50	pyrimidine nucleotide catabolic process (GO:0006244)	2.94216979
51	protein polyglutamylation (GO:0018095)	2.92818077
52	ribosomal small subunit assembly (GO:0000028)	2.92444813
53	regulation of phospholipid biosynthetic process (GO:0071071)	2.91157357
54	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.88045983
55	midbrain development (GO:0030901)	2.86043536
56	proteasome assembly (GO:0043248)	2.84974047
57	DNA ligation (GO:0006266)	2.84310886
58	regulation of glucokinase activity (GO:0033131)	2.79964369
59	regulation of hexokinase activity (GO:1903299)	2.79964369
60	viral transcription (GO:0019083)	2.78514763
61	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.77473883
62	nucleotide salvage (GO:0043173)	2.75295090
63	urinary tract smooth muscle contraction (GO:0014848)	2.74931823
64	positive regulation of developmental pigmentation (GO:0048087)	2.73429405
65	amyloid precursor protein catabolic process (GO:0042987)	2.72196402
66	intestinal epithelial cell development (GO:0060576)	2.69544286
67	chromatin remodeling at centromere (GO:0031055)	2.69408608
68	base-excision repair, AP site formation (GO:0006285)	2.68427191
69	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.68291682
70	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.67299528
71	positive regulation of triglyceride lipase activity (GO:0061365)	2.66972451
72	positive regulation of lipoprotein lipase activity (GO:0051006)	2.66972451
73	positive thymic T cell selection (GO:0045059)	2.63934076
74	pyrimidine-containing compound catabolic process (GO:0072529)	2.63447911
75	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.61485279
76	ATP synthesis coupled proton transport (GO:0015986)	2.61164392
77	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.61164392
78	CENP-A containing nucleosome assembly (GO:0034080)	2.60240101
79	IMP biosynthetic process (GO:0006188)	2.59858318
80	icosanoid biosynthetic process (GO:0046456)	2.59849930
81	fatty acid derivative biosynthetic process (GO:1901570)	2.59849930
82	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.59732895
83	microtubule polymerization or depolymerization (GO:0031109)	2.59647022
84	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.57892747
85	peristalsis (GO:0030432)	2.52597035
86	positive regulation of B cell differentiation (GO:0045579)	2.51162058
87	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.50752033
88	mitochondrial respiratory chain complex assembly (GO:0033108)	2.50477608
89	translational termination (GO:0006415)	2.50004769
90	regulation of triglyceride catabolic process (GO:0010896)	2.48843406
91	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.47097047
92	alkaloid metabolic process (GO:0009820)	2.47042025
93	positive regulation of gastrulation (GO:2000543)	2.46217569
94	glutathione biosynthetic process (GO:0006750)	2.45555746
95	limb bud formation (GO:0060174)	2.44865362
96	glutathione metabolic process (GO:0006749)	2.44862725
97	respiratory chain complex IV assembly (GO:0008535)	2.44415739
98	ubiquinone biosynthetic process (GO:0006744)	2.44101753
99	cytochrome complex assembly (GO:0017004)	2.41417404
100	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.41290253

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.40067669
2	STAT6_21828071_ChIP-Seq_BEAS2B_Human	4.66468882
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.69244089
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.40296019
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.23075160
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.21592500
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.82432746
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.69202684
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.57825233
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.35623102
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.14780874
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.09564644
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.04046953
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.95793521
15	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.95608325
16	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.83488102
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.79331582
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.75646675
19	VDR_22108803_ChIP-Seq_LS180_Human	1.72807505
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.72642431
21	EWS_26573619_Chip-Seq_HEK293_Human	1.70179515
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.69461421
23	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.63253170
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.61333859
25	P300_19829295_ChIP-Seq_ESCs_Human	1.59064215
26	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.58758985
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.58689657
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.58404279
29	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.56276698
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.55794414
31	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.52301772
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.41679924
33	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41302221
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.38865260
35	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.37086711
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35147079
37	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.33339796
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.29562695
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.26586539
40	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26586539
41	VDR_23849224_ChIP-Seq_CD4+_Human	1.25201726
42	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.24816549
43	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.24621511
44	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.22799855
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21330757
46	ELK1_19687146_ChIP-ChIP_HELA_Human	1.20787170
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.14031650
48	GATA3_26560356_Chip-Seq_TH2_Human	1.13522843
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.13288879
50	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.13114673
51	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.12999685
52	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.12584396
53	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.12482085
54	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.12118469
55	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.11586841
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11539322
57	MYB_26560356_Chip-Seq_TH2_Human	1.07842653
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07384580
59	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05941370
60	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05262742
61	ERG_20517297_ChIP-Seq_VCAP_Human	1.05211725
62	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04446210
63	ER_23166858_ChIP-Seq_MCF-7_Human	1.04193204
64	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.01817870
65	FUS_26573619_Chip-Seq_HEK293_Human	1.01804771
66	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.99735410
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.99540634
68	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.98634876
69	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.98494023
70	IRF1_19129219_ChIP-ChIP_H3396_Human	0.98478543
71	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98200600
72	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97162283
73	TP53_22573176_ChIP-Seq_HFKS_Human	0.96572987
74	P53_22387025_ChIP-Seq_ESCs_Mouse	0.95888115
75	RUNX2_22187159_ChIP-Seq_PCA_Human	0.94575401
76	RUNX_20019798_ChIP-Seq_JUKART_Human	0.94450812
77	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.94427560
78	TCF4_22108803_ChIP-Seq_LS180_Human	0.94099653
79	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.93140403
80	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.91985052
81	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.91190315
82	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.90834075
83	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.90754322
84	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.89451744
85	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.89270209
86	AR_20517297_ChIP-Seq_VCAP_Human	0.89070168
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.88310555
88	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.88240270
89	CBP_20019798_ChIP-Seq_JUKART_Human	0.88240270
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.88128097
91	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.87259746
92	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.87184014
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.87031298
94	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.86226155
95	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.85406536
96	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.83601161
97	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.83545831
98	STAT1_17558387_ChIP-Seq_HELA_Human	0.82572036
99	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.82245921
100	SMAD4_21799915_ChIP-Seq_A2780_Human	0.82033708

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003283_abnormal_digestive_organ	5.87244289
2	MP0000566_synostosis	4.74694040
3	MP0003806_abnormal_nucleotide_metabolis	4.04233941
4	MP0000372_irregular_coat_pigmentation	3.23303842
5	MP0003183_abnormal_peptide_metabolism	3.01869966
6	MP0008995_early_reproductive_senescence	2.97522231
7	MP0002653_abnormal_ependyma_morphology	2.75729972
8	MP0002938_white_spotting	2.70885698
9	MP0002163_abnormal_gland_morphology	2.60687880
10	MP0008789_abnormal_olfactory_epithelium	2.53138044
11	MP0003011_delayed_dark_adaptation	2.52898083
12	MP0002234_abnormal_pharynx_morphology	2.43722873
13	MP0003136_yellow_coat_color	2.38920745
14	MP0005671_abnormal_response_to	2.22748731
15	MP0008961_abnormal_basal_metabolism	2.12020783
16	MP0000569_abnormal_digit_pigmentation	2.08883508
17	MP0004145_abnormal_muscle_electrophysio	2.07718654
18	MP0005394_taste/olfaction_phenotype	2.05035215
19	MP0005499_abnormal_olfactory_system	2.05035215
20	MP0005377_hearing/vestibular/ear_phenot	2.03345879
21	MP0003878_abnormal_ear_physiology	2.03345879
22	MP0005084_abnormal_gallbladder_morpholo	1.97062853
23	MP0003938_abnormal_ear_development	1.86140215
24	MP0001986_abnormal_taste_sensitivity	1.79073034
25	MP0002928_abnormal_bile_duct	1.74133452
26	MP0004381_abnormal_hair_follicle	1.64951241
27	MP0003252_abnormal_bile_duct	1.62243495
28	MP0004133_heterotaxia	1.60401671
29	MP0002277_abnormal_respiratory_mucosa	1.57095270
30	MP0003315_abnormal_perineum_morphology	1.56425885
31	MP0005187_abnormal_penis_morphology	1.53390734
32	MP0010386_abnormal_urinary_bladder	1.51240608
33	MP0005670_abnormal_white_adipose	1.46555190
34	MP0002138_abnormal_hepatobiliary_system	1.45762884
35	MP0004742_abnormal_vestibular_system	1.44212512
36	MP0009379_abnormal_foot_pigmentation	1.44049557
37	MP0002102_abnormal_ear_morphology	1.42578815
38	MP0005379_endocrine/exocrine_gland_phen	1.38597898
39	MP0005075_abnormal_melanosome_morpholog	1.28133548
40	MP0005645_abnormal_hypothalamus_physiol	1.25115862
41	MP0003137_abnormal_impulse_conducting	1.20908645
42	MP0008875_abnormal_xenobiotic_pharmacok	1.18252801
43	MP0002160_abnormal_reproductive_system	1.11497441
44	MP0003959_abnormal_lean_body	1.11293230
45	MP0001968_abnormal_touch/_nociception	1.11108672
46	MP0005551_abnormal_eye_electrophysiolog	1.07618200
47	MP0000049_abnormal_middle_ear	1.06026929
48	MP0009278_abnormal_bone_marrow	1.05591197
49	MP0001119_abnormal_female_reproductive	1.03380518
50	MP0003880_abnormal_central_pattern	1.03191492
51	MP0003122_maternal_imprinting	0.99216788
52	MP0001529_abnormal_vocalization	0.97556224
53	MP0003866_abnormal_defecation	0.95279704
54	MP0004885_abnormal_endolymph	0.92724391
55	MP0005423_abnormal_somatic_nervous	0.92067693
56	MP0005085_abnormal_gallbladder_physiolo	0.90944691
57	MP0003763_abnormal_thymus_physiology	0.87897030
58	MP0006276_abnormal_autonomic_nervous	0.87657256
59	MP0005389_reproductive_system_phenotype	0.87546341
60	MP0005266_abnormal_metabolism	0.85562740
61	MP0003937_abnormal_limbs/digits/tail_de	0.85560116
62	MP0000026_abnormal_inner_ear	0.83659870
63	MP0001764_abnormal_homeostasis	0.81629068
64	MP0006292_abnormal_olfactory_placode	0.81051374
65	MP0002405_respiratory_system_inflammati	0.80190268
66	MP0002095_abnormal_skin_pigmentation	0.79673824
67	MP0008872_abnormal_physiological_respon	0.79170564
68	MP0006072_abnormal_retinal_apoptosis	0.79050112
69	MP0001958_emphysema	0.77971178
70	MP0001485_abnormal_pinna_reflex	0.76820756
71	MP0003567_abnormal_fetal_cardiomyocyte	0.74898183
72	MP0001293_anophthalmia	0.74603708
73	MP0001800_abnormal_humoral_immune	0.73132567
74	MP0002736_abnormal_nociception_after	0.72693669
75	MP0002132_abnormal_respiratory_system	0.70785970
76	MP0003195_calcinosis	0.69186428
77	MP0003119_abnormal_digestive_system	0.69089904
78	MP0001963_abnormal_hearing_physiology	0.68946315
79	MP0001486_abnormal_startle_reflex	0.67551320
80	MP0002067_abnormal_sensory_capabilities	0.67387618
81	MP0002075_abnormal_coat/hair_pigmentati	0.66415093
82	MP0005397_hematopoietic_system_phenotyp	0.66415058
83	MP0001545_abnormal_hematopoietic_system	0.66415058
84	MP0004142_abnormal_muscle_tone	0.66307323
85	MP0005220_abnormal_exocrine_pancreas	0.66271479
86	MP0005253_abnormal_eye_physiology	0.66097638
87	MP0000631_abnormal_neuroendocrine_gland	0.65352756
88	MP0002557_abnormal_social/conspecific_i	0.65330348
89	MP0003646_muscle_fatigue	0.64742697
90	MP0002233_abnormal_nose_morphology	0.63043338
91	MP0001905_abnormal_dopamine_level	0.62436417
92	MP0000537_abnormal_urethra_morphology	0.60324951
93	MP0001879_abnormal_lymphatic_vessel	0.58934239
94	MP0000538_abnormal_urinary_bladder	0.57923782
95	MP0003943_abnormal_hepatobiliary_system	0.57915086
96	MP0000613_abnormal_salivary_gland	0.56322868
97	MP0009785_altered_susceptibility_to	0.56298838
98	MP0002638_abnormal_pupillary_reflex	0.54473830
99	MP0003724_increased_susceptibility_to	0.54053509
100	MP0002751_abnormal_autonomic_nervous	0.54008377

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Delayed CNS myelination (HP:0002188)	4.67117348
2	Thyroid-stimulating hormone excess (HP:0002925)	4.35301846
3	Pancreatic cysts (HP:0001737)	3.77620710
4	True hermaphroditism (HP:0010459)	3.64630978
5	Oral leukoplakia (HP:0002745)	3.60641071
6	Esophageal atresia (HP:0002032)	3.44600097
7	Hypothermia (HP:0002045)	3.22849145
8	3-Methylglutaconic aciduria (HP:0003535)	3.15512173
9	Renal cortical cysts (HP:0000803)	3.10740011
10	Hypoplasia of the capital femoral epiphysis (HP:0003090)	3.05728254
11	Pancreatic fibrosis (HP:0100732)	3.04696823
12	Respiratory difficulties (HP:0002880)	2.87165666
13	Absent epiphyses (HP:0010577)	2.85861418
14	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.85861418
15	Increased serum pyruvate (HP:0003542)	2.79663544
16	Bilateral microphthalmos (HP:0007633)	2.77842494
17	Absent phalangeal crease (HP:0006109)	2.77008908
18	Occipital encephalocele (HP:0002085)	2.74791970
19	Cystic liver disease (HP:0006706)	2.64512945
20	Large earlobe (HP:0009748)	2.62337659
21	Hepatocellular necrosis (HP:0001404)	2.59788800
22	Carpal bone hypoplasia (HP:0001498)	2.54985632
23	Abnormality of the parietal bone (HP:0002696)	2.53256411
24	Inability to walk (HP:0002540)	2.51761042
25	Gastrointestinal atresia (HP:0002589)	2.49497528
26	Type II lissencephaly (HP:0007260)	2.45929484
27	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.43929966
28	Hepatic necrosis (HP:0002605)	2.42234334
29	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.41455959
30	Hypoplasia of the fovea (HP:0007750)	2.41455959
31	Preaxial hand polydactyly (HP:0001177)	2.31737908
32	Congenital stationary night blindness (HP:0007642)	2.29385102
33	Severe combined immunodeficiency (HP:0004430)	2.27169723
34	Anencephaly (HP:0002323)	2.26695214
35	Unilateral renal agenesis (HP:0000122)	2.24030779
36	Pendular nystagmus (HP:0012043)	2.22814989
37	Concave nail (HP:0001598)	2.22656821
38	Increased corneal curvature (HP:0100692)	2.22337056
39	Keratoconus (HP:0000563)	2.22337056
40	Choroideremia (HP:0001139)	2.22035965
41	Rectal prolapse (HP:0002035)	2.20748184
42	Trigonocephaly (HP:0000243)	2.20507071
43	Severe global developmental delay (HP:0011344)	2.20073055
44	Cerebellar dysplasia (HP:0007033)	2.19566935
45	Vacuolated lymphocytes (HP:0001922)	2.19116808
46	Abnormal finger flexion creases (HP:0006143)	2.17866054
47	Microvesicular hepatic steatosis (HP:0001414)	2.16078292
48	Aplastic anemia (HP:0001915)	2.12773086
49	Abnormality of fatty-acid metabolism (HP:0004359)	2.10904494
50	Mitochondrial inheritance (HP:0001427)	2.09303944
51	Abnormality of the antihelix (HP:0009738)	2.08984592
52	Colon cancer (HP:0003003)	2.01830720
53	Abnormality of glycolysis (HP:0004366)	2.01278702
54	Lipid accumulation in hepatocytes (HP:0006561)	2.00506957
55	Abnormality of the fovea (HP:0000493)	1.99222815
56	Abnormality of the renal cortex (HP:0011035)	1.96426430
57	Male pseudohermaphroditism (HP:0000037)	1.94999756
58	Absent/shortened dynein arms (HP:0200106)	1.94810994
59	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.94810994
60	Vertebral fusion (HP:0002948)	1.94077549
61	Short tibia (HP:0005736)	1.91414335
62	Vertebral arch anomaly (HP:0008438)	1.90918608
63	Deformed sella turcica (HP:0002681)	1.90637602
64	Chromsome breakage (HP:0040012)	1.90546140
65	Postaxial foot polydactyly (HP:0001830)	1.89899215
66	Sclerocornea (HP:0000647)	1.87738431
67	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.87273925
68	Disproportionate short-trunk short stature (HP:0003521)	1.86815962
69	Abnormality of the pons (HP:0007361)	1.85357048
70	Calf muscle hypertrophy (HP:0008981)	1.85354733
71	Thyroiditis (HP:0100646)	1.84449294
72	Absent thumb (HP:0009777)	1.82345477
73	Small hand (HP:0200055)	1.82204394
74	Abnormality of midbrain morphology (HP:0002418)	1.82012081
75	Molar tooth sign on MRI (HP:0002419)	1.82012081
76	Muscle hypertrophy of the lower extremities (HP:0008968)	1.81364354
77	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.80324098
78	Beaking of vertebral bodies (HP:0004568)	1.79967722
79	Attenuation of retinal blood vessels (HP:0007843)	1.79059514
80	Retinal dysplasia (HP:0007973)	1.77644161
81	Triphalangeal thumb (HP:0001199)	1.77514505
82	Dicarboxylic aciduria (HP:0003215)	1.75953266
83	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.75953266
84	Hypoplasia of the pons (HP:0012110)	1.75519277
85	Meningocele (HP:0002435)	1.75170158
86	Abnormality of the preputium (HP:0100587)	1.72512728
87	Meningioma (HP:0002858)	1.72398628
88	Abnormality of chromosome stability (HP:0003220)	1.72115023
89	Morphological abnormality of the middle ear (HP:0008609)	1.71959776
90	Abnormality of T cells (HP:0002843)	1.71782382
91	Elevated erythrocyte sedimentation rate (HP:0003565)	1.71402134
92	Optic nerve coloboma (HP:0000588)	1.71030877
93	Narrow forehead (HP:0000341)	1.69575287
94	Increased CSF lactate (HP:0002490)	1.69536809
95	Abnormality of alanine metabolism (HP:0010916)	1.67779606
96	Hyperalaninemia (HP:0003348)	1.67779606
97	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.67779606
98	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.67677410
99	Horseshoe kidney (HP:0000085)	1.64716909
100	Cupped ear (HP:0000378)	1.63780245

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	4.25682291
2	CDK8	3.59398241
3	ZAK	3.12358776
4	BLK	2.88459781
5	PNCK	2.84219116
6	EPHB2	2.75893856
7	FRK	2.74549246
8	TESK2	2.67728616
9	TGFBR1	2.60537585
10	TXK	2.52044849
11	PIK3CG	2.40816546
12	PLK4	2.40035293
13	ACVR1B	2.20783331
14	TSSK6	2.17692072
15	VRK2	1.98441657
16	MAP4K2	1.95252198
17	MAPKAPK3	1.78790271
18	KDR	1.76854380
19	LMTK2	1.69048201
20	FGFR2	1.58270691
21	SCYL2	1.57786992
22	PASK	1.50474874
23	OBSCN	1.42310022
24	PLK2	1.41149313
25	STK16	1.35473561
26	MAP3K9	1.29155465
27	PDK2	1.27062841
28	GRK6	1.22191337
29	MAPK13	1.21059701
30	TAF1	1.16001413
31	ERBB3	1.14325203
32	GRK5	1.14091744
33	SYK	1.09693322
34	ADRBK2	1.08638071
35	BUB1	1.03099479
36	NUAK1	1.01905322
37	FES	1.00305043
38	VRK1	0.95657556
39	GRK1	0.95117207
40	DYRK2	0.93530798
41	PHKG1	0.93159277
42	PHKG2	0.93159277
43	TRPM7	0.90648759
44	BRSK2	0.86449448
45	TNK2	0.85202946
46	WNK3	0.84148391
47	UHMK1	0.83149539
48	PLK3	0.80670191
49	NEK2	0.80617177
50	CDK19	0.79402787
51	BTK	0.78657002
52	NEK1	0.78407131
53	TGFBR2	0.78165192
54	ITK	0.77595790
55	ZAP70	0.76574794
56	DYRK3	0.76435769
57	SRPK1	0.74961730
58	CDK9	0.72779447
59	GRK7	0.71644408
60	IRAK2	0.70374953
61	TAOK3	0.70079900
62	MAP4K1	0.68873343
63	INSRR	0.67016681
64	TEC	0.62828754
65	DAPK2	0.61906771
66	IKBKE	0.59637052
67	MAPK11	0.58242747
68	KIT	0.57457969
69	CSK	0.56947453
70	MAPKAPK5	0.53595708
71	LYN	0.52828503
72	MARK1	0.51283488
73	ERBB2	0.49690984
74	MAPK15	0.48549283
75	MAP3K4	0.47761901
76	PIM1	0.47440651
77	ATR	0.46482979
78	PRKCE	0.46458641
79	KSR1	0.46431039
80	WEE1	0.46099485
81	SGK223	0.45995872
82	SGK494	0.45995872
83	DYRK1A	0.43989395
84	LCK	0.43609150
85	PRKG1	0.41114153
86	MAP2K4	0.38415938
87	IRAK4	0.35722667
88	MAPK12	0.35650157
89	CASK	0.35341603
90	PLK1	0.35100052
91	ATM	0.32950143
92	TBK1	0.32313916
93	PRKACB	0.31396506
94	DYRK1B	0.29958588
95	PAK3	0.29481634
96	YES1	0.28838395
97	PIK3CA	0.28728399
98	ADRBK1	0.27647957
99	PRKCQ	0.25504640
100	PRKCG	0.25078286

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	3.94765536
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.55972520
3	Ribosome_Homo sapiens_hsa03010	3.42711955
4	Phototransduction_Homo sapiens_hsa04744	3.34383642
5	Parkinsons disease_Homo sapiens_hsa05012	3.34369949
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.86747584
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.75219914
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.71774017
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.58264986
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.45891184
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.41952740
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.18965929
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.13561429
14	Alzheimers disease_Homo sapiens_hsa05010	2.07950352
15	Huntingtons disease_Homo sapiens_hsa05016	1.84557606
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.84098917
17	Proteasome_Homo sapiens_hsa03050	1.82796578
18	Butanoate metabolism_Homo sapiens_hsa00650	1.81586634
19	Non-homologous end-joining_Homo sapiens_hsa03450	1.77446688
20	Homologous recombination_Homo sapiens_hsa03440	1.76892111
21	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.65760810
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.62720383
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.52291128
24	RNA degradation_Homo sapiens_hsa03018	1.51016697
25	One carbon pool by folate_Homo sapiens_hsa00670	1.42861994
26	Antigen processing and presentation_Homo sapiens_hsa04612	1.39842773
27	DNA replication_Homo sapiens_hsa03030	1.33545008
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.26627523
29	Purine metabolism_Homo sapiens_hsa00230	1.21971674
30	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.21647833
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.16993218
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14416277
33	Folate biosynthesis_Homo sapiens_hsa00790	1.12863728
34	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.11731657
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.99261302
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97112537
37	Protein export_Homo sapiens_hsa03060	0.96433827
38	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.93628530
39	Base excision repair_Homo sapiens_hsa03410	0.92229880
40	Peroxisome_Homo sapiens_hsa04146	0.90315208
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90226415
42	Graft-versus-host disease_Homo sapiens_hsa05332	0.90140564
43	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.89019813
44	Glutathione metabolism_Homo sapiens_hsa00480	0.88668229
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86126905
46	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.85808407
47	Retinol metabolism_Homo sapiens_hsa00830	0.85242024
48	Spliceosome_Homo sapiens_hsa03040	0.80105854
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.79944187
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.79618077
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77486907
52	Basal transcription factors_Homo sapiens_hsa03022	0.74993470
53	Allograft rejection_Homo sapiens_hsa05330	0.73898768
54	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.70800222
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.69913448
56	Type I diabetes mellitus_Homo sapiens_hsa04940	0.69165347
57	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.64154750
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63183008
59	Complement and coagulation cascades_Homo sapiens_hsa04610	0.61642701
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.61513160
61	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.58387775
62	Phenylalanine metabolism_Homo sapiens_hsa00360	0.58348053
63	Mismatch repair_Homo sapiens_hsa03430	0.55947029
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54680671
65	Nicotine addiction_Homo sapiens_hsa05033	0.52155888
66	Oocyte meiosis_Homo sapiens_hsa04114	0.51937737
67	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.50612992
68	RNA polymerase_Homo sapiens_hsa03020	0.50522889
69	Metabolic pathways_Homo sapiens_hsa01100	0.46804023
70	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.45450900
71	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.44147768
72	Pyrimidine metabolism_Homo sapiens_hsa00240	0.43105442
73	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.42701185
74	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.41545539
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41287963
76	Tyrosine metabolism_Homo sapiens_hsa00350	0.40901192
77	Asthma_Homo sapiens_hsa05310	0.37903334
78	Bile secretion_Homo sapiens_hsa04976	0.36739015
79	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.35273751
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.33489755
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.31077798
82	Notch signaling pathway_Homo sapiens_hsa04330	0.30273948
83	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.28761440
84	Morphine addiction_Homo sapiens_hsa05032	0.28036432
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.27716345
86	Propanoate metabolism_Homo sapiens_hsa00640	0.27658937
87	Amphetamine addiction_Homo sapiens_hsa05031	0.27636386
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27589698
89	Shigellosis_Homo sapiens_hsa05131	0.26668260
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.25856983
91	Tryptophan metabolism_Homo sapiens_hsa00380	0.25291626
92	Collecting duct acid secretion_Homo sapiens_hsa04966	0.24443270
93	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.23987007
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.23613795
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.22917915
96	Calcium signaling pathway_Homo sapiens_hsa04020	0.22811434
97	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.18025142
98	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.17891613
99	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.16560425
100	Cell cycle_Homo sapiens_hsa04110	0.16361004

IGBP1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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