IGBP1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phosphate ion transport (GO:0006817)9.66612998
2peptidyl-tyrosine autophosphorylation (GO:0038083)8.94193265
3response to parathyroid hormone (GO:0071107)8.90572924
4urate metabolic process (GO:0046415)8.56451000
5phosphate ion transmembrane transport (GO:0035435)7.01094357
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.75440587
7aminoglycoside antibiotic metabolic process (GO:0030647)5.58696235
8tachykinin receptor signaling pathway (GO:0007217)5.31576122
9peristalsis (GO:0030432)4.99395847
10transmission of nerve impulse (GO:0019226)4.99290827
11regulation of dopamine metabolic process (GO:0042053)4.95022604
12regulation of catecholamine metabolic process (GO:0042069)4.95022604
13response to lead ion (GO:0010288)4.90684708
14positive regulation of uterine smooth muscle contraction (GO:0070474)4.73277624
15regulation of RNA export from nucleus (GO:0046831)4.68697812
16negative regulation of cAMP-mediated signaling (GO:0043951)4.53367149
17regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.48878773
18regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.48878773
19regulation of natural killer cell differentiation (GO:0032823)4.43706640
20sensory perception of taste (GO:0050909)4.40379956
21substrate-independent telencephalic tangential migration (GO:0021826)4.39688806
22substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.39688806
23response to mercury ion (GO:0046689)4.35366322
24negative regulation of protein localization to cell surface (GO:2000009)4.34313104
25energy homeostasis (GO:0097009)4.31760562
26fat-soluble vitamin biosynthetic process (GO:0042362)4.28173158
27detection of bacterium (GO:0016045)4.22678428
28behavioral response to nicotine (GO:0035095)4.13847237
29phosphate ion homeostasis (GO:0055062)4.11577848
30trivalent inorganic anion homeostasis (GO:0072506)4.11577848
31histone H4-K12 acetylation (GO:0043983)3.97776225
32dopamine transport (GO:0015872)3.95035966
33opioid receptor signaling pathway (GO:0038003)3.92401134
34positive regulation of action potential (GO:0045760)3.87638159
35maternal behavior (GO:0042711)3.85515782
36regulation of hippo signaling (GO:0035330)3.83044913
37detection of other organism (GO:0098543)3.81752938
38leukotriene biosynthetic process (GO:0019370)3.72107692
39negative regulation of JAK-STAT cascade (GO:0046426)3.67922687
40positive regulation of heart rate (GO:0010460)3.65620928
41negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.64786148
42striatum development (GO:0021756)3.61160991
43protein localization to cilium (GO:0061512)3.59221554
44hyperosmotic salinity response (GO:0042538)3.55797079
45negative regulation of heart rate (GO:0010459)3.50683635
46regulation of uterine smooth muscle contraction (GO:0070472)3.48918576
47neuronal action potential (GO:0019228)3.47201783
48regulation of nucleobase-containing compound transport (GO:0032239)3.44598534
49pentose metabolic process (GO:0019321)3.43952647
50positive regulation of histone H3-K4 methylation (GO:0051571)3.42401736
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.41790566
52parental behavior (GO:0060746)3.39394083
53leukotriene metabolic process (GO:0006691)3.38273935
54viral transcription (GO:0019083)3.37164811
55regulation of synaptic transmission, dopaminergic (GO:0032225)3.36364472
56response to growth hormone (GO:0060416)3.33909470
57prepulse inhibition (GO:0060134)3.33375367
58response to magnesium ion (GO:0032026)3.30903560
59translational termination (GO:0006415)3.30684751
60indole-containing compound metabolic process (GO:0042430)3.17844860
61DNA methylation involved in gamete generation (GO:0043046)3.17307964
62regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.14492274
63positive regulation of protein export from nucleus (GO:0046827)3.13200630
64synaptic transmission, dopaminergic (GO:0001963)3.11769626
65cornea development in camera-type eye (GO:0061303)3.08621430
66positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.08037043
67glycoside metabolic process (GO:0016137)3.07411610
68piRNA metabolic process (GO:0034587)3.06785962
69regulation of neurotransmitter uptake (GO:0051580)3.03025839
70detection of light stimulus involved in visual perception (GO:0050908)3.01271669
71detection of light stimulus involved in sensory perception (GO:0050962)3.01271669
72methionine biosynthetic process (GO:0009086)2.98356165
73SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94545668
74CTP biosynthetic process (GO:0006241)2.92458982
75CTP metabolic process (GO:0046036)2.92458982
76phasic smooth muscle contraction (GO:0014821)2.90924009
77hematopoietic stem cell proliferation (GO:0071425)2.90901691
78cotranslational protein targeting to membrane (GO:0006613)2.90565660
79otic vesicle formation (GO:0030916)2.90315911
80positive regulation of calcium ion import (GO:0090280)2.89047169
81epoxygenase P450 pathway (GO:0019373)2.87020081
82regulation of G0 to G1 transition (GO:0070316)2.86727513
83synaptic transmission, cholinergic (GO:0007271)2.84809847
84protein targeting to ER (GO:0045047)2.82895180
85phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.82825465
86response to thyroid hormone (GO:0097066)2.82200297
87regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.80726710
88regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.80496915
89regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78322020
90adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.77341963
91mitochondrion distribution (GO:0048311)2.76141757
92establishment of protein localization to endoplasmic reticulum (GO:0072599)2.74565095
93tricarboxylic acid metabolic process (GO:0072350)2.74036108
94quinone biosynthetic process (GO:1901663)2.73874341
95nephron epithelium morphogenesis (GO:0072088)2.71046398
96nephron tubule morphogenesis (GO:0072078)2.71046398
97ribosomal large subunit biogenesis (GO:0042273)2.69351675
98head development (GO:0060322)2.68863306
99hormone catabolic process (GO:0042447)2.68354436
100histone H2A acetylation (GO:0043968)10.9051855

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.84094324
2GBX2_23144817_ChIP-Seq_PC3_Human2.94614726
3ZNF274_21170338_ChIP-Seq_K562_Hela2.50612740
4FUS_26573619_Chip-Seq_HEK293_Human2.46690834
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40357225
6ZNF263_19887448_ChIP-Seq_K562_Human2.14502759
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.10776800
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03167962
9GATA1_22025678_ChIP-Seq_K562_Human12.5775061
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83405198
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79128484
12VDR_22108803_ChIP-Seq_LS180_Human1.75860198
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72196525
14UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70476777
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65650241
16MYC_18940864_ChIP-ChIP_HL60_Human1.59583761
17DROSHA_22980978_ChIP-Seq_HELA_Human1.58972760
18PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48721091
19WT1_19549856_ChIP-ChIP_CCG9911_Human1.47817757
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47081128
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45987697
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43050173
23NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41421856
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.39634085
25RXR_22108803_ChIP-Seq_LS180_Human1.39282046
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.36805210
27AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35890277
28SMAD3_21741376_ChIP-Seq_EPCs_Human1.34631982
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34299907
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34299907
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33171685
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32670977
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30091668
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30013200
35STAT3_23295773_ChIP-Seq_U87_Human1.29409574
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28544249
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27477005
38SMAD4_21741376_ChIP-Seq_EPCs_Human1.27246579
39IGF1R_20145208_ChIP-Seq_DFB_Human1.26913413
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.26556805
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26140821
42RUNX2_22187159_ChIP-Seq_PCA_Human1.23928890
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.22921688
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.22601334
45ER_23166858_ChIP-Seq_MCF-7_Human1.21986129
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19647238
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18879435
48PRDM14_20953172_ChIP-Seq_ESCs_Human1.18807413
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17912128
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17783068
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17599461
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17220656
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16170306
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15628440
55NCOR_22424771_ChIP-Seq_293T_Human1.15266841
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.14149410
57AR_25329375_ChIP-Seq_VCAP_Human1.13630595
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08581424
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08420809
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.07613234
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06283606
62SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05088383
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04537020
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.04517440
65ELK1_19687146_ChIP-ChIP_HELA_Human1.04420429
66P300_19829295_ChIP-Seq_ESCs_Human1.03753517
67SMAD4_21799915_ChIP-Seq_A2780_Human1.03300261
68HTT_18923047_ChIP-ChIP_STHdh_Human1.03285469
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02642878
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02359641
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.02174023
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01605718
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01465891
74E2F1_17053090_ChIP-ChIP_MCF-7_Human1.01327479
75REST_21632747_ChIP-Seq_MESCs_Mouse1.00539128
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99800735
77NANOG_19829295_ChIP-Seq_ESCs_Human0.98083704
78SOX2_19829295_ChIP-Seq_ESCs_Human0.98083704
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97348376
80GABP_17652178_ChIP-ChIP_JURKAT_Human0.95093974
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93875159
82E2F1_18555785_Chip-Seq_ESCs_Mouse0.92331372
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91269762
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90775817
85SPI1_20517297_ChIP-Seq_HL60_Human0.90073377
86FOXH1_21741376_ChIP-Seq_ESCs_Human0.88439165
87TCF4_22108803_ChIP-Seq_LS180_Human0.87384198
88CDX2_22108803_ChIP-Seq_LS180_Human0.87294864
89FLI1_21867929_ChIP-Seq_TH2_Mouse0.87278202
90CMYC_18555785_Chip-Seq_ESCs_Mouse0.86409529
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85688835
92STAT3_18555785_Chip-Seq_ESCs_Mouse0.85201717
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84940230
94ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84608515
95MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84099801
96STAT1_17558387_ChIP-Seq_HELA_Human0.84001565
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.83593702
98RUNX_20019798_ChIP-Seq_JUKART_Human0.82239618
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82166943
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.81754952

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.57425019
2MP0003878_abnormal_ear_physiology3.85395808
3MP0005377_hearing/vestibular/ear_phenot3.85395808
4MP0001545_abnormal_hematopoietic_system3.44910773
5MP0005397_hematopoietic_system_phenotyp3.44910773
6MP0005645_abnormal_hypothalamus_physiol3.11583201
7MP0004510_myositis2.95443389
8MP0010386_abnormal_urinary_bladder2.89932403
9MP0003646_muscle_fatigue2.83873288
10MP0002332_abnormal_exercise_endurance2.64517456
11MP0003045_fibrosis2.37938613
12MP0008877_abnormal_DNA_methylation2.36443677
13MP0006276_abnormal_autonomic_nervous2.29938010
14MP0002138_abnormal_hepatobiliary_system2.19831807
15MP0001486_abnormal_startle_reflex2.18179343
16MP0002735_abnormal_chemical_nociception2.09421759
17MP0003136_yellow_coat_color2.07535170
18MP0009379_abnormal_foot_pigmentation2.07338854
19MP0006072_abnormal_retinal_apoptosis2.04106118
20MP0001501_abnormal_sleep_pattern2.03241612
21MP0004145_abnormal_muscle_electrophysio1.89025815
22MP0001485_abnormal_pinna_reflex1.87822719
23MP0004019_abnormal_vitamin_homeostasis1.81356392
24MP0004808_abnormal_hematopoietic_stem1.78806406
25MP0009046_muscle_twitch1.76845331
26MP0003283_abnormal_digestive_organ1.75174657
27MP0004142_abnormal_muscle_tone1.67674917
28MP0000749_muscle_degeneration1.63707647
29MP0005220_abnormal_exocrine_pancreas1.62554368
30MP0002733_abnormal_thermal_nociception1.61346002
31MP0000516_abnormal_urinary_system1.61333717
32MP0005367_renal/urinary_system_phenotyp1.61333717
33MP0000751_myopathy1.58150211
34MP0004484_altered_response_of1.52703646
35MP0005551_abnormal_eye_electrophysiolog1.49559715
36MP0001986_abnormal_taste_sensitivity1.46270855
37MP0000538_abnormal_urinary_bladder1.40838793
38MP0004215_abnormal_myocardial_fiber1.37951538
39MP0003635_abnormal_synaptic_transmissio1.36469525
40MP0002909_abnormal_adrenal_gland1.36410755
41MP0000427_abnormal_hair_cycle1.32988270
42MP0009672_abnormal_birth_weight1.30220567
43MP0005319_abnormal_enzyme/_coenzyme1.26829792
44MP0009745_abnormal_behavioral_response1.25376883
45MP0005360_urolithiasis1.25045305
46MP0002063_abnormal_learning/memory/cond1.24701238
47MP0002163_abnormal_gland_morphology1.23462954
48MP0004858_abnormal_nervous_system1.22550409
49MP0004085_abnormal_heartbeat1.22435878
50MP0002160_abnormal_reproductive_system1.21654819
51MP0001970_abnormal_pain_threshold1.20062585
52MP0003195_calcinosis1.19761545
53MP0004270_analgesia1.18661681
54MP0008775_abnormal_heart_ventricle1.18582084
55MP0002184_abnormal_innervation1.15347314
56MP0000631_abnormal_neuroendocrine_gland1.14191172
57MP0009765_abnormal_xenobiotic_induced1.13993098
58MP0002837_dystrophic_cardiac_calcinosis1.08446402
59MP0003252_abnormal_bile_duct1.04804424
60MP0000383_abnormal_hair_follicle1.04319282
61MP0000747_muscle_weakness1.02761091
62MP0005389_reproductive_system_phenotype1.02343116
63MP0003137_abnormal_impulse_conducting1.01853038
64MP0002272_abnormal_nervous_system1.01474394
65MP0001765_abnormal_ion_homeostasis1.00699935
66MP0001968_abnormal_touch/_nociception0.98619949
67MP0005379_endocrine/exocrine_gland_phen0.98534465
68MP0002572_abnormal_emotion/affect_behav0.98187122
69MP0003959_abnormal_lean_body0.96968889
70MP0005253_abnormal_eye_physiology0.93601001
71MP0001529_abnormal_vocalization0.93570522
72MP0009333_abnormal_splenocyte_physiolog0.91833224
73MP0000750_abnormal_muscle_regeneration0.90707761
74MP0001756_abnormal_urination0.89448556
75MP0002734_abnormal_mechanical_nocicepti0.89394628
76MP0005195_abnormal_posterior_eye0.89357665
77MP0005636_abnormal_mineral_homeostasis0.85023268
78MP0003183_abnormal_peptide_metabolism0.84734822
79MP0001963_abnormal_hearing_physiology0.83032273
80MP0000566_synostosis0.81118837
81MP0001764_abnormal_homeostasis0.81067461
82MP0002067_abnormal_sensory_capabilities0.78008662
83MP0010678_abnormal_skin_adnexa0.77204297
84MP0003763_abnormal_thymus_physiology0.76922272
85MP0000465_gastrointestinal_hemorrhage0.72937894
86MP0005647_abnormal_sex_gland0.71425581
87MP0006138_congestive_heart_failure0.71123128
88MP0000613_abnormal_salivary_gland0.70038319
89MP0002106_abnormal_muscle_physiology0.69942227
90MP0004133_heterotaxia0.69254775
91MP0000955_abnormal_spinal_cord0.67695315
92MP0000537_abnormal_urethra_morphology0.67560582
93MP0006035_abnormal_mitochondrial_morpho0.67417924
94MP0006292_abnormal_olfactory_placode0.67267859
95MP0000678_abnormal_parathyroid_gland0.66964049
96MP0000733_abnormal_muscle_development0.66812251
97MP0005620_abnormal_muscle_contractility0.66672573
98MP0002168_other_aberrant_phenotype0.66234965
99MP0002064_seizures0.66123371
100MP0001348_abnormal_lacrimal_gland0.64843939

Predicted human phenotypes

RankGene SetZ-score
1Generalized aminoaciduria (HP:0002909)9.71432464
2Proximal tubulopathy (HP:0000114)6.87087127
3Severe visual impairment (HP:0001141)6.22830836
4Pendular nystagmus (HP:0012043)5.92833098
5True hermaphroditism (HP:0010459)4.65894025
6Myokymia (HP:0002411)4.33935310
7Pancreatic fibrosis (HP:0100732)4.24017786
8Congenital stationary night blindness (HP:0007642)4.12472969
9Genetic anticipation (HP:0003743)3.92405510
10Popliteal pterygium (HP:0009756)3.85229286
11Pancreatic cysts (HP:0001737)3.77636429
12Cystic liver disease (HP:0006706)3.72725497
13Abnormality of placental membranes (HP:0011409)3.63641838
14Amniotic constriction ring (HP:0009775)3.63641838
15Absent rod-and cone-mediated responses on ERG (HP:0007688)3.61071882
16J-shaped sella turcica (HP:0002680)3.49580714
17Abnormality of urine glucose concentration (HP:0011016)3.44643088
18Glycosuria (HP:0003076)3.44643088
19Long clavicles (HP:0000890)3.38484003
20Aplasia/Hypoplasia of the tongue (HP:0010295)3.21814358
21Attenuation of retinal blood vessels (HP:0007843)3.17845251
22Anencephaly (HP:0002323)3.10544844
23Stenosis of the external auditory canal (HP:0000402)3.03581242
24Hyperkalemia (HP:0002153)2.98706914
25Malignant hyperthermia (HP:0002047)2.86033851
26Oligodactyly (hands) (HP:0001180)2.81646306
27Keratoconus (HP:0000563)2.74136887
28Increased corneal curvature (HP:0100692)2.74136887
29Abolished electroretinogram (ERG) (HP:0000550)2.74010225
30Renal cortical cysts (HP:0000803)2.68025558
31Fetal akinesia sequence (HP:0001989)2.63610862
32Sclerocornea (HP:0000647)2.62632457
33Rickets (HP:0002748)2.60223213
34Parakeratosis (HP:0001036)2.60202353
35Nonprogressive disorder (HP:0003680)2.59943422
36Postaxial foot polydactyly (HP:0001830)2.56944133
37Abnormality of the labia majora (HP:0012881)2.55951535
38Oral leukoplakia (HP:0002745)2.54409559
39Split foot (HP:0001839)2.53809988
40Congenital, generalized hypertrichosis (HP:0004540)2.51139313
41Furrowed tongue (HP:0000221)2.49237071
42Hyperphosphaturia (HP:0003109)2.48637717
43Abnormality of cells of the erythroid lineage (HP:0012130)2.45497600
44Abnormal ciliary motility (HP:0012262)2.39125465
45Abnormal rod and cone electroretinograms (HP:0008323)2.36358336
46Unilateral renal agenesis (HP:0000122)2.35519137
47Abnormality of macular pigmentation (HP:0008002)2.34511190
48Reticulocytopenia (HP:0001896)2.34377252
49Clumsiness (HP:0002312)2.34280557
50Palpebral edema (HP:0100540)2.23530540
51Abnormal respiratory motile cilium morphology (HP:0005938)2.22794739
52Abnormal respiratory epithelium morphology (HP:0012253)2.22794739
53Molar tooth sign on MRI (HP:0002419)2.18839557
54Abnormality of midbrain morphology (HP:0002418)2.18839557
55Decreased central vision (HP:0007663)2.18478744
56Abnormal number of erythroid precursors (HP:0012131)2.17998933
57Recurrent corneal erosions (HP:0000495)2.17150916
58Constricted visual fields (HP:0001133)2.16643160
59Hepatic necrosis (HP:0002605)2.12799860
60Progressive cerebellar ataxia (HP:0002073)2.11116734
61Preaxial hand polydactyly (HP:0001177)2.10737994
62Male pseudohermaphroditism (HP:0000037)2.10341309
63Beaking of vertebral bodies (HP:0004568)2.07839152
64Cystic hygroma (HP:0000476)2.05188489
65Aplasia of the musculature (HP:0100854)2.03046091
66Optic nerve hypoplasia (HP:0000609)2.00632847
67Oligodactyly (HP:0012165)1.99501261
68Neonatal death (HP:0003811)1.94096392
69Abnormal urine phosphate concentration (HP:0012599)1.92601381
70Acute lymphatic leukemia (HP:0006721)1.91941899
71Broad metatarsal (HP:0001783)1.90304718
72Abnormality of the lumbar spine (HP:0100712)1.88602918
73Decreased circulating renin level (HP:0003351)1.87252547
74Calf muscle hypertrophy (HP:0008981)1.86432147
75Rib fusion (HP:0000902)1.86345982
76Palpitations (HP:0001962)1.85313876
77Muscle hypertrophy of the lower extremities (HP:0008968)1.82841382
78Congenital hepatic fibrosis (HP:0002612)1.82576710
79Neonatal respiratory distress (HP:0002643)1.80372971
80Type 2 muscle fiber atrophy (HP:0003554)1.78817778
81Congenital sensorineural hearing impairment (HP:0008527)1.77519583
82Nausea (HP:0002018)1.77158692
83Deformed sella turcica (HP:0002681)1.76842808
84Status epilepticus (HP:0002133)1.74786058
85Absent phalangeal crease (HP:0006109)1.71646687
86Occipital encephalocele (HP:0002085)1.69813485
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69467531
88Chronic hepatic failure (HP:0100626)1.68727991
89Focal seizures (HP:0007359)1.67894559
90Abnormal biliary tract physiology (HP:0012439)1.67753305
91Bile duct proliferation (HP:0001408)1.67753305
92Degeneration of the lateral corticospinal tracts (HP:0002314)1.66740818
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66740818
94Hypoglycemic coma (HP:0001325)1.65487114
95Postaxial hand polydactyly (HP:0001162)1.64868489
96Symphalangism affecting the phalanges of the hand (HP:0009773)1.63085408
97Myotonia (HP:0002486)1.62154923
98Abnormal respiratory motile cilium physiology (HP:0012261)1.60300868
99Hypoplastic heart (HP:0001961)1.58957657
100Abnormality of the renal collecting system (HP:0004742)1.58642919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.63517112
2FRK4.45355049
3FGFR23.25851463
4TXK3.25475528
5MAP4K22.84429154
6OBSCN2.61222310
7ADRBK22.38063759
8GRK72.36769586
9MAP3K42.19662439
10AURKA2.06783271
11MOS2.03698547
12MAP2K72.00067049
13BCKDK1.97130819
14PHKG21.75948251
15PHKG11.75948251
16MAP2K41.63734584
17BLK1.59297489
18PINK11.58441316
19GRK51.57814465
20ICK1.55301144
21MAP3K121.53159818
22MUSK1.48833758
23TGFBR21.47803622
24BMPR1B1.38197091
25DAPK21.37985580
26EPHA31.37785740
27TAOK31.35317800
28TNK21.31851078
29NTRK21.24565180
30JAK31.23293775
31PIK3CA1.18246318
32NEK11.09372308
33TGFBR11.01858364
34BTK0.98983134
35SYK0.98468631
36WNK30.94381760
37CSNK1G10.93988098
38RPS6KA40.90620188
39MAP2K60.88472174
40PIK3CG0.87725689
41INSRR0.86347452
42MAP4K10.85553743
43EPHA40.84017960
44CSNK1G30.83301164
45NTRK30.82368259
46STK110.79994500
47TYRO30.78980678
48DYRK20.76588239
49PTK2B0.73451541
50MARK10.73256938
51TRIM280.72074076
52PRKACB0.71545034
53PRKACA0.71399237
54DAPK30.70969538
55TTN0.65872870
56TRPM70.64933460
57PASK0.64686603
58CSNK1A1L0.62719921
59GRK10.61039052
60OXSR10.60498817
61CSNK1G20.60262991
62KIT0.59620295
63DDR20.57977485
64MATK0.57843711
65CSNK1A10.57440011
66PRKCG0.55530128
67PRKCH0.53786172
68LYN0.52394334
69ADRBK10.50017439
70MAP3K70.49547705
71IKBKE0.49511720
72MAPK40.48527860
73PRKCD0.48028135
74PRKACG0.46116376
75DAPK10.44769837
76CAMK10.44001475
77MAP3K50.43887683
78LCK0.43357189
79INSR0.40873286
80STK160.40554553
81MAP3K110.40318189
82MAP3K20.37838305
83JAK20.37729087
84DYRK1B0.37040476
85MAPK80.36233106
86STK100.36212768
87PRKCA0.35931670
88TIE10.35643857
89CAMK2A0.35293366
90CAMK2B0.34864290
91PAK30.34152540
92IKBKB0.33547720
93PRKG20.33495044
94PDK10.33486211
95SRPK10.33130415
96EGFR0.33066493
97RPS6KA30.32151264
98MAPK100.31597948
99ACVR1B0.30304905
100RPS6KA60.28510061

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046144.83109260
2Nicotine addiction_Homo sapiens_hsa050333.12966949
3Taste transduction_Homo sapiens_hsa047423.08668711
4Ribosome_Homo sapiens_hsa030102.84997545
5Phototransduction_Homo sapiens_hsa047442.52383810
6Selenocompound metabolism_Homo sapiens_hsa004502.50297378
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.44129484
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.41533713
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.40688986
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.95785137
11Caffeine metabolism_Homo sapiens_hsa002321.95560842
12Morphine addiction_Homo sapiens_hsa050321.93925933
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.91087014
14Starch and sucrose metabolism_Homo sapiens_hsa005001.73421130
15Butanoate metabolism_Homo sapiens_hsa006501.71550428
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.70282881
17Sulfur relay system_Homo sapiens_hsa041221.69374620
18Oxidative phosphorylation_Homo sapiens_hsa001901.69279765
19Retinol metabolism_Homo sapiens_hsa008301.66305531
20Cocaine addiction_Homo sapiens_hsa050301.63509794
21GABAergic synapse_Homo sapiens_hsa047271.63113276
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61263306
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60403342
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55130757
25Cardiac muscle contraction_Homo sapiens_hsa042601.53356618
26Parkinsons disease_Homo sapiens_hsa050121.48399290
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.47989085
28Sulfur metabolism_Homo sapiens_hsa009201.45918224
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.39848097
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36431036
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34141843
32Chemical carcinogenesis_Homo sapiens_hsa052041.33711711
33Asthma_Homo sapiens_hsa053101.33391685
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20351117
35Basal cell carcinoma_Homo sapiens_hsa052171.19488962
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18616424
37Amphetamine addiction_Homo sapiens_hsa050311.16168499
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.14533207
39Calcium signaling pathway_Homo sapiens_hsa040201.14235426
40Glutamatergic synapse_Homo sapiens_hsa047241.05877006
41Alzheimers disease_Homo sapiens_hsa050101.05608071
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04834411
43Renin secretion_Homo sapiens_hsa049241.04130848
44Hedgehog signaling pathway_Homo sapiens_hsa043401.01911668
45Arginine and proline metabolism_Homo sapiens_hsa003300.96683057
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94836364
47Protein export_Homo sapiens_hsa030600.93315610
48Circadian entrainment_Homo sapiens_hsa047130.92385271
49Linoleic acid metabolism_Homo sapiens_hsa005910.92350303
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91362818
51Salivary secretion_Homo sapiens_hsa049700.87364398
52Graft-versus-host disease_Homo sapiens_hsa053320.84015250
53African trypanosomiasis_Homo sapiens_hsa051430.79996391
54Histidine metabolism_Homo sapiens_hsa003400.75887762
55Tryptophan metabolism_Homo sapiens_hsa003800.73037392
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.72509271
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70418356
58Dorso-ventral axis formation_Homo sapiens_hsa043200.68848540
59Homologous recombination_Homo sapiens_hsa034400.68469252
60Autoimmune thyroid disease_Homo sapiens_hsa053200.66176099
61Cholinergic synapse_Homo sapiens_hsa047250.65014358
62Huntingtons disease_Homo sapiens_hsa050160.64821223
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64439454
64cAMP signaling pathway_Homo sapiens_hsa040240.64147637
65Allograft rejection_Homo sapiens_hsa053300.63632627
66Serotonergic synapse_Homo sapiens_hsa047260.63045465
67Type I diabetes mellitus_Homo sapiens_hsa049400.62984646
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60626894
69Arginine biosynthesis_Homo sapiens_hsa002200.60334981
70Ovarian steroidogenesis_Homo sapiens_hsa049130.57376860
71RNA polymerase_Homo sapiens_hsa030200.55019698
72Dopaminergic synapse_Homo sapiens_hsa047280.54959252
73Arachidonic acid metabolism_Homo sapiens_hsa005900.54351409
74Olfactory transduction_Homo sapiens_hsa047400.52419542
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52054711
76Vitamin digestion and absorption_Homo sapiens_hsa049770.50240139
77Rheumatoid arthritis_Homo sapiens_hsa053230.49589112
78Pyrimidine metabolism_Homo sapiens_hsa002400.49403725
79Axon guidance_Homo sapiens_hsa043600.47928859
80Collecting duct acid secretion_Homo sapiens_hsa049660.45310538
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44406635
82Circadian rhythm_Homo sapiens_hsa047100.44388550
83Protein digestion and absorption_Homo sapiens_hsa049740.43519560
84Nitrogen metabolism_Homo sapiens_hsa009100.42972530
85Alcoholism_Homo sapiens_hsa050340.41990179
86ABC transporters_Homo sapiens_hsa020100.40568514
87Insulin secretion_Homo sapiens_hsa049110.39157964
88Glucagon signaling pathway_Homo sapiens_hsa049220.39050466
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36592554
90Gap junction_Homo sapiens_hsa045400.34664202
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34612711
92beta-Alanine metabolism_Homo sapiens_hsa004100.33966816
93Oxytocin signaling pathway_Homo sapiens_hsa049210.33107584
94Regulation of autophagy_Homo sapiens_hsa041400.32761076
95Proteasome_Homo sapiens_hsa030500.32287741
96Tuberculosis_Homo sapiens_hsa051520.30430192
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29603014
98Staphylococcus aureus infection_Homo sapiens_hsa051500.29585129
99Dilated cardiomyopathy_Homo sapiens_hsa054140.28344459
100Melanogenesis_Homo sapiens_hsa049160.26472631

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