IGBP1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1growth hormone secretion (GO:0030252)5.41934151
2sequestering of actin monomers (GO:0042989)5.19037581
3kynurenine metabolic process (GO:0070189)4.80491511
4positive regulation of growth hormone secretion (GO:0060124)4.79960588
5water-soluble vitamin biosynthetic process (GO:0042364)4.46694866
6ubiquinone metabolic process (GO:0006743)4.38038560
7pyrimidine nucleobase catabolic process (GO:0006208)4.31654986
8ubiquinone biosynthetic process (GO:0006744)4.24530050
9negative regulation of synaptic transmission, GABAergic (GO:0032229)4.24276209
10cellular ketone body metabolic process (GO:0046950)4.11553514
11indole-containing compound catabolic process (GO:0042436)4.11040109
12indolalkylamine catabolic process (GO:0046218)4.11040109
13tryptophan catabolic process (GO:0006569)4.11040109
14positive regulation of oligodendrocyte differentiation (GO:0048714)3.96938365
15positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.94267897
16negative regulation of mast cell activation (GO:0033004)3.74564196
17negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.62688110
18ketone body metabolic process (GO:1902224)3.62306706
19nucleobase catabolic process (GO:0046113)3.59666056
20response to pheromone (GO:0019236)3.48942669
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.48729795
22platelet dense granule organization (GO:0060155)3.43529384
23energy coupled proton transport, down electrochemical gradient (GO:0015985)3.43516283
24ATP synthesis coupled proton transport (GO:0015986)3.43516283
25negative regulation of calcium ion transport into cytosol (GO:0010523)3.42887534
26protein-cofactor linkage (GO:0018065)3.42230063
27anterograde synaptic vesicle transport (GO:0048490)3.40599762
28parturition (GO:0007567)3.40341066
29gamma-aminobutyric acid transport (GO:0015812)3.40090371
30lactate metabolic process (GO:0006089)3.38787452
31electron transport chain (GO:0022900)3.36972173
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.36647562
33regulation of microtubule-based movement (GO:0060632)3.35197939
34quinone biosynthetic process (GO:1901663)3.33715817
35indolalkylamine metabolic process (GO:0006586)3.32587081
36behavioral response to nicotine (GO:0035095)3.31616158
37respiratory electron transport chain (GO:0022904)3.29858620
38positive regulation of protein homodimerization activity (GO:0090073)3.28465920
39negative regulation of heart rate (GO:0010459)3.20466043
40regulation of growth hormone secretion (GO:0060123)3.12861272
41tachykinin receptor signaling pathway (GO:0007217)3.12066564
42adaptation of signaling pathway (GO:0023058)3.11418209
43adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.08851125
44iron-sulfur cluster assembly (GO:0016226)3.06886157
45metallo-sulfur cluster assembly (GO:0031163)3.06886157
46tryptophan metabolic process (GO:0006568)3.02773810
47negative regulation of cation channel activity (GO:2001258)3.02431519
48regulation of mitotic spindle checkpoint (GO:1903504)3.00561361
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.00561361
50behavioral response to ethanol (GO:0048149)2.96858880
51xenobiotic catabolic process (GO:0042178)2.94245740
52glyoxylate metabolic process (GO:0046487)2.94039369
53purine deoxyribonucleotide catabolic process (GO:0009155)2.93631297
54alkaloid metabolic process (GO:0009820)2.88151608
55mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.87764053
56positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.87764053
57axoneme assembly (GO:0035082)2.86730902
58reflex (GO:0060004)2.86556888
59preassembly of GPI anchor in ER membrane (GO:0016254)2.84076530
60adenosine metabolic process (GO:0046085)2.82811194
61protein complex biogenesis (GO:0070271)2.80478044
62aldehyde catabolic process (GO:0046185)2.79169388
63terpenoid biosynthetic process (GO:0016114)2.75186824
64negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.71868199
65hydrogen ion transmembrane transport (GO:1902600)2.71246574
66protein polyglutamylation (GO:0018095)2.71163069
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69583817
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69583817
69benzene-containing compound metabolic process (GO:0042537)2.68872845
70proton transport (GO:0015992)2.67670970
71negative regulation of telomere maintenance (GO:0032205)2.67574250
72positive regulation of vesicle fusion (GO:0031340)2.65970753
73DNA double-strand break processing (GO:0000729)2.65699737
74regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.65088254
75vitamin biosynthetic process (GO:0009110)2.64833842
76determination of adult lifespan (GO:0008340)2.64811315
77fucose catabolic process (GO:0019317)2.64522388
78L-fucose metabolic process (GO:0042354)2.64522388
79L-fucose catabolic process (GO:0042355)2.64522388
80regulation of mitochondrial translation (GO:0070129)2.63977328
81positive thymic T cell selection (GO:0045059)2.63501364
82negative regulation of DNA-templated transcription, elongation (GO:0032785)2.62489976
83anterograde axon cargo transport (GO:0008089)2.62292869
84hydrogen transport (GO:0006818)2.60781005
85regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.60016238
86nucleoside diphosphate catabolic process (GO:0009134)2.56942003
87negative regulation of oxidoreductase activity (GO:0051354)2.55622330
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.54617764
89neuronal action potential (GO:0019228)2.54293031
90oxidative demethylation (GO:0070989)2.54082166
91dopamine transport (GO:0015872)2.53361783
92regulation of skeletal muscle contraction (GO:0014819)2.52995283
93cell wall macromolecule metabolic process (GO:0044036)2.51969231
94negative regulation of calcium ion transmembrane transport (GO:1903170)2.51118669
95negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.51118669
96protein K11-linked deubiquitination (GO:0035871)2.50581483
97piRNA metabolic process (GO:0034587)2.49853273
98regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.48781057
99regulation of cellular amino acid metabolic process (GO:0006521)2.46048250
100respiratory chain complex IV assembly (GO:0008535)2.45659006

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.06874594
2VDR_22108803_ChIP-Seq_LS180_Human3.04935826
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.84340018
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82740450
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82046319
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65924071
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64364782
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.50340477
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.49995683
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21672499
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14199101
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13285993
13ER_23166858_ChIP-Seq_MCF-7_Human2.10720846
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.08201154
15GBX2_23144817_ChIP-Seq_PC3_Human2.05756545
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.00409815
17TAF15_26573619_Chip-Seq_HEK293_Human1.95921941
18IGF1R_20145208_ChIP-Seq_DFB_Human1.94960057
19TP53_22573176_ChIP-Seq_HFKS_Human1.89216341
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88526875
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87453465
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81917318
23VDR_23849224_ChIP-Seq_CD4+_Human1.73126009
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73046486
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72453459
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59976978
27REST_21632747_ChIP-Seq_MESCs_Mouse1.56841726
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56032716
29AR_20517297_ChIP-Seq_VCAP_Human1.54639010
30FUS_26573619_Chip-Seq_HEK293_Human1.52640854
31NCOR_22424771_ChIP-Seq_293T_Human1.51269171
32EWS_26573619_Chip-Seq_HEK293_Human1.51099243
33CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.47073574
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.46560324
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46552234
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45344873
37IRF1_19129219_ChIP-ChIP_H3396_Human1.44583737
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42993800
39P300_19829295_ChIP-Seq_ESCs_Human1.42926799
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.40983233
41ELK1_19687146_ChIP-ChIP_HELA_Human1.40389388
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.38643692
43FOXP3_21729870_ChIP-Seq_TREG_Human1.37165940
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.36827366
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.36721395
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31500606
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.29603492
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29603492
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28938082
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.26897047
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.25627956
52CBP_20019798_ChIP-Seq_JUKART_Human1.25588965
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25588965
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23469283
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23407045
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22715672
57MYC_18940864_ChIP-ChIP_HL60_Human1.22658453
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22519439
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22064447
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21558566
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.21548634
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20350440
63PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.20230003
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20032551
65MYC_19829295_ChIP-Seq_ESCs_Human1.15947014
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14081577
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13800934
68RNF2_27304074_Chip-Seq_NSC_Mouse1.12650682
69HOXB7_26014856_ChIP-Seq_BT474_Human1.11148097
70EZH2_22144423_ChIP-Seq_EOC_Human1.10294398
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10267830
72NANOG_20526341_ChIP-Seq_ESCs_Human1.10161129
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09120020
74RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08552534
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05884000
76OCT4_20526341_ChIP-Seq_ESCs_Human1.05782010
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05600988
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00317361
79POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99906394
80AR_25329375_ChIP-Seq_VCAP_Human0.99484966
81SOX2_19829295_ChIP-Seq_ESCs_Human0.97606034
82NANOG_19829295_ChIP-Seq_ESCs_Human0.97606034
83RUNX2_22187159_ChIP-Seq_PCA_Human0.96651035
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96623222
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96554576
86EZH2_27294783_Chip-Seq_NPCs_Mouse0.95209402
87AR_21572438_ChIP-Seq_LNCaP_Human0.95128402
88CRX_20693478_ChIP-Seq_RETINA_Mouse0.93479594
89PHF8_20622853_ChIP-Seq_HELA_Human0.93001950
90RBPJ_21746931_ChIP-Seq_IB4_Human0.92927027
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.91284629
92TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90669816
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.90543441
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.89428222
95PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89295025
96TAF2_19829295_ChIP-Seq_ESCs_Human0.88461723
97ERA_21632823_ChIP-Seq_H3396_Human0.87552869
98YY1_21170310_ChIP-Seq_MESCs_Mouse0.87505062
99EZH2_27304074_Chip-Seq_ESCs_Mouse0.87326897
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87260217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.50744118
2MP0001986_abnormal_taste_sensitivity3.76138648
3MP0003787_abnormal_imprinting3.20690345
4MP0006276_abnormal_autonomic_nervous2.83772029
5MP0003123_paternal_imprinting2.68133572
6MP0004142_abnormal_muscle_tone2.51383104
7MP0002102_abnormal_ear_morphology2.48473801
8MP0008875_abnormal_xenobiotic_pharmacok2.46676710
9MP0008872_abnormal_physiological_respon2.41467006
10MP0002653_abnormal_ependyma_morphology2.29653633
11MP0005423_abnormal_somatic_nervous2.29255400
12MP0001968_abnormal_touch/_nociception2.17307943
13MP0002909_abnormal_adrenal_gland2.02358859
14MP0000372_irregular_coat_pigmentation2.01464978
15MP0009745_abnormal_behavioral_response1.87871405
16MP0005645_abnormal_hypothalamus_physiol1.84547829
17MP0001905_abnormal_dopamine_level1.82322246
18MP0001501_abnormal_sleep_pattern1.80313149
19MP0006035_abnormal_mitochondrial_morpho1.75453615
20MP0004147_increased_porphyrin_level1.73509514
21MP0008877_abnormal_DNA_methylation1.71896186
22MP0009046_muscle_twitch1.65880658
23MP0000427_abnormal_hair_cycle1.58568466
24MP0002638_abnormal_pupillary_reflex1.58083140
25MP0002163_abnormal_gland_morphology1.57342592
26MP0000383_abnormal_hair_follicle1.55568490
27MP0005671_abnormal_response_to1.53855840
28MP0005084_abnormal_gallbladder_morpholo1.51030950
29MP0005379_endocrine/exocrine_gland_phen1.47845751
30MP0005551_abnormal_eye_electrophysiolog1.45512302
31MP0001486_abnormal_startle_reflex1.42836592
32MP0002837_dystrophic_cardiac_calcinosis1.42135943
33MP0003195_calcinosis1.41975330
34MP0004043_abnormal_pH_regulation1.41244688
35MP0002736_abnormal_nociception_after1.40621435
36MP0004885_abnormal_endolymph1.40370869
37MP0006072_abnormal_retinal_apoptosis1.37156201
38MP0002876_abnormal_thyroid_physiology1.34932468
39MP0004742_abnormal_vestibular_system1.32964950
40MP0002272_abnormal_nervous_system1.31000498
41MP0005257_abnormal_intraocular_pressure1.29469178
42MP0003136_yellow_coat_color1.28314305
43MP0008058_abnormal_DNA_repair1.27695784
44MP0002067_abnormal_sensory_capabilities1.26620204
45MP0002234_abnormal_pharynx_morphology1.25980242
46MP0003121_genomic_imprinting1.24905294
47MP0002928_abnormal_bile_duct1.22465776
48MP0004270_analgesia1.21882769
49MP0005386_behavior/neurological_phenoty1.19283904
50MP0004924_abnormal_behavior1.19283904
51MP0002572_abnormal_emotion/affect_behav1.16943791
52MP0006036_abnormal_mitochondrial_physio1.15182215
53MP0001919_abnormal_reproductive_system1.14694031
54MP0002557_abnormal_social/conspecific_i1.14609709
55MP0003635_abnormal_synaptic_transmissio1.12622653
56MP0001529_abnormal_vocalization1.11132238
57MP0002277_abnormal_respiratory_mucosa1.09865006
58MP0002064_seizures1.08848670
59MP0001970_abnormal_pain_threshold1.07071210
60MP0000631_abnormal_neuroendocrine_gland1.06815485
61MP0005167_abnormal_blood-brain_barrier1.05322983
62MP0000778_abnormal_nervous_system1.04090627
63MP0005377_hearing/vestibular/ear_phenot1.03149118
64MP0003878_abnormal_ear_physiology1.03149118
65MP0001984_abnormal_olfaction1.02853487
66MP0003137_abnormal_impulse_conducting1.01839603
67MP0002733_abnormal_thermal_nociception1.01715053
68MP0010386_abnormal_urinary_bladder0.97282938
69MP0002063_abnormal_learning/memory/cond0.95075625
70MP0003786_premature_aging0.94825223
71MP0003879_abnormal_hair_cell0.90567772
72MP0000639_abnormal_adrenal_gland0.88484310
73MP0001485_abnormal_pinna_reflex0.88022970
74MP0001502_abnormal_circadian_rhythm0.87571681
75MP0002160_abnormal_reproductive_system0.86358326
76MP0000230_abnormal_systemic_arterial0.85639769
77MP0002095_abnormal_skin_pigmentation0.85079149
78MP0003938_abnormal_ear_development0.84825713
79MP0003011_delayed_dark_adaptation0.84551159
80MP0005253_abnormal_eye_physiology0.83347149
81MP0001440_abnormal_grooming_behavior0.82865250
82MP0005389_reproductive_system_phenotype0.82184932
83MP0002069_abnormal_eating/drinking_beha0.81286641
84MP0010678_abnormal_skin_adnexa0.81128646
85MP0005367_renal/urinary_system_phenotyp0.79171700
86MP0000516_abnormal_urinary_system0.79171700
87MP0004133_heterotaxia0.78772723
88MP0002735_abnormal_chemical_nociception0.77860513
89MP0000026_abnormal_inner_ear0.77100342
90MP0002752_abnormal_somatic_nervous0.76621353
91MP0001963_abnormal_hearing_physiology0.76048432
92MP0003122_maternal_imprinting0.75092191
93MP0002882_abnormal_neuron_morphology0.73279225
94MP0005365_abnormal_bile_salt0.73229275
95MP0005636_abnormal_mineral_homeostasis0.70839422
96MP0008775_abnormal_heart_ventricle0.70371728
97MP0004859_abnormal_synaptic_plasticity0.70053609
98MP0005360_urolithiasis0.70018878
99MP0002734_abnormal_mechanical_nocicepti0.68782378
100MP0003633_abnormal_nervous_system0.68469455

Predicted human phenotypes

RankGene SetZ-score
1Stomach cancer (HP:0012126)4.76758159
2Pancreatic fibrosis (HP:0100732)4.03648745
3Congenital stationary night blindness (HP:0007642)4.00222885
43-Methylglutaconic aciduria (HP:0003535)3.73901624
5True hermaphroditism (HP:0010459)3.62223008
6Pancreatic cysts (HP:0001737)3.46492016
7Mitochondrial inheritance (HP:0001427)3.19126279
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.15991478
9Abnormality of alanine metabolism (HP:0010916)3.15991478
10Hyperalaninemia (HP:0003348)3.15991478
11Abnormality of the labia minora (HP:0012880)3.12555344
12Abnormal biliary tract physiology (HP:0012439)3.12438857
13Bile duct proliferation (HP:0001408)3.12438857
14Occipital encephalocele (HP:0002085)3.11291591
15Epileptic encephalopathy (HP:0200134)3.04794366
16Abnormality of the renal cortex (HP:0011035)3.04166656
17Chronic hepatic failure (HP:0100626)3.03208816
18Increased hepatocellular lipid droplets (HP:0006565)3.02570315
19Hepatocellular necrosis (HP:0001404)3.00519740
20Autoimmune thrombocytopenia (HP:0001973)2.96326555
21Sclerocornea (HP:0000647)2.96202528
22Hepatic necrosis (HP:0002605)2.93263661
23Colon cancer (HP:0003003)2.91238088
24Optic nerve coloboma (HP:0000588)2.82116742
25Lipid accumulation in hepatocytes (HP:0006561)2.71293186
26Methylmalonic acidemia (HP:0002912)2.70942126
27Abnormality of lateral ventricle (HP:0030047)2.68201702
28Increased CSF lactate (HP:0002490)2.64353063
29Cerebral hypomyelination (HP:0006808)2.64346562
30Increased IgM level (HP:0003496)2.63179218
31Delayed CNS myelination (HP:0002188)2.62280848
32Amyotrophic lateral sclerosis (HP:0007354)2.59603046
33Agitation (HP:0000713)2.58905136
34Molar tooth sign on MRI (HP:0002419)2.56842538
35Abnormality of midbrain morphology (HP:0002418)2.56842538
36Tubulointerstitial fibrosis (HP:0005576)2.54754489
37Retinal atrophy (HP:0001105)2.54140792
38Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48305131
39Amblyopia (HP:0000646)2.46158490
40Abnormality of B cell number (HP:0010975)2.42672294
41CNS hypomyelination (HP:0003429)2.41537434
42Attenuation of retinal blood vessels (HP:0007843)2.41219098
43Aplastic anemia (HP:0001915)2.34240222
44Cerebellar dysplasia (HP:0007033)2.30910980
45Congenital, generalized hypertrichosis (HP:0004540)2.27821830
46Pendular nystagmus (HP:0012043)2.27054991
47Neoplasm of the adrenal cortex (HP:0100641)2.26107423
48Absent thumb (HP:0009777)2.25094307
49Polyuria (HP:0000103)2.23516369
50Aplasia/Hypoplasia of the tongue (HP:0010295)2.21141221
51Nephronophthisis (HP:0000090)2.21083601
52Acute necrotizing encephalopathy (HP:0006965)2.19868648
53Polydipsia (HP:0001959)2.19862577
54Abnormal drinking behavior (HP:0030082)2.19862577
55Methylmalonic aciduria (HP:0012120)2.19802449
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.17794413
57Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15899675
58Renal Fanconi syndrome (HP:0001994)2.12239096
59Type II lissencephaly (HP:0007260)2.11990684
60Abnormality of the renal medulla (HP:0100957)2.10413563
61Metabolic alkalosis (HP:0200114)2.10405595
62Increased intramyocellular lipid droplets (HP:0012240)2.10010276
63Abnormal mitochondria in muscle tissue (HP:0008316)2.09143869
64Medial flaring of the eyebrow (HP:0010747)2.07499803
65Progressive macrocephaly (HP:0004481)2.06599734
66Broad-based gait (HP:0002136)2.06211638
67Abnormal number of erythroid precursors (HP:0012131)2.05975300
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05972600
69Dicarboxylic aciduria (HP:0003215)2.05972600
70Abnormal rod and cone electroretinograms (HP:0008323)2.05646825
71Ketosis (HP:0001946)2.05049216
72Stenosis of the external auditory canal (HP:0000402)2.05019820
73Status epilepticus (HP:0002133)2.03529715
74Hypokalemic alkalosis (HP:0001949)2.03477343
75Postaxial foot polydactyly (HP:0001830)2.01914814
76Renal cortical cysts (HP:0000803)2.00252754
77Abnormality of cells of the erythroid lineage (HP:0012130)2.00195004
78Cystic liver disease (HP:0006706)1.99373952
79Lactic acidosis (HP:0003128)1.98161954
80Severe muscular hypotonia (HP:0006829)1.92678006
81Anencephaly (HP:0002323)1.90273839
82Abolished electroretinogram (ERG) (HP:0000550)1.90063775
83Furrowed tongue (HP:0000221)1.89963190
84Emotional lability (HP:0000712)1.86940507
85Eosinophilia (HP:0001880)1.84460927
86Male pseudohermaphroditism (HP:0000037)1.83991345
87Abnormal urine output (HP:0012590)1.81881617
88Erythroderma (HP:0001019)1.81480909
89Atrophy/Degeneration involving motor neurons (HP:0007373)1.80388318
90Absent speech (HP:0001344)1.79059760
91Hypsarrhythmia (HP:0002521)1.78871107
92Increased corneal curvature (HP:0100692)1.78811527
93Keratoconus (HP:0000563)1.78811527
94Alkalosis (HP:0001948)1.76960865
95Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.76329061
96CNS demyelination (HP:0007305)1.75175086
97Neoplasm of the adrenal gland (HP:0100631)1.73546861
98Gait imbalance (HP:0002141)1.73169365
99Acute encephalopathy (HP:0006846)1.71867498
100Increased serum lactate (HP:0002151)1.71549297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.40675182
2TESK24.17227315
3PINK14.15128658
4CAMKK23.49126884
5FRK3.09481911
6ADRBK23.08387219
7VRK22.34535790
8EPHA42.34440983
9KDR2.18527008
10LIMK12.04600549
11WNK41.96043897
12CDK191.88787416
13STK38L1.81510217
14TESK11.74166943
15TAOK31.69869466
16ZAK1.66896394
17BMPR1B1.66068535
18MAP3K41.58466645
19CAMKK11.57262183
20BRSK21.53998361
21BCR1.53192711
22GRK11.47086410
23PLK21.42342476
24MAP3K121.35986550
25MAP2K71.32821519
26BCKDK1.30971970
27VRK11.30723519
28ERBB31.30441643
29WNK31.21597204
30CSNK1A1L1.19098686
31CSNK1G31.15934742
32PHKG11.13471691
33PHKG21.13471691
34DYRK21.10650573
35MAPKAPK31.08982899
36TRPM71.07881785
37CASK1.03352982
38PASK1.01697778
39GRK51.00570918
40TLK10.94946930
41GRK60.94551674
42CSNK1G20.94495605
43MAPKAPK50.93411126
44IRAK40.92410179
45CSNK1G10.91187005
46TXK0.87410921
47PDK20.84652570
48MAPK130.82453794
49NUAK10.82398306
50FGFR20.82381227
51DAPK20.78272595
52ADRBK10.73246626
53BMX0.71691751
54PAK30.71586168
55PLK30.64788569
56OXSR10.64737355
57PRKCE0.61066334
58EIF2AK30.60995536
59PLK40.60388544
60MARK10.59975106
61INSRR0.59613282
62STK390.58675080
63TYRO30.57005057
64WNK10.54562758
65DAPK10.54363411
66MYLK0.52670705
67NTRK20.49391206
68MAP4K20.47855531
69SRPK10.47794615
70BRSK10.45665258
71MATK0.44813112
72MINK10.42048802
73TNIK0.41684201
74MAP3K110.41517412
75RPS6KB20.41304407
76OBSCN0.39119748
77SYK0.38185198
78PRKAA10.37521223
79PRKCG0.37034737
80CAMK10.34739079
81DDR20.34558817
82IGF1R0.33908723
83SCYL20.32984086
84TIE10.31648818
85NTRK30.30930239
86ABL20.30746801
87ROCK10.30682408
88CAMK40.30369093
89BLK0.30254562
90TRIM280.29372569
91PRKACA0.28800469
92TNK20.26281224
93ITK0.25550091
94TAOK20.25240986
95PRKD20.24210643
96PRKACB0.22995381
97LMTK20.22568483
98CSNK1D0.22529491
99CSNK1A10.22502110
100ABL10.22283810

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.59110868
2Oxidative phosphorylation_Homo sapiens_hsa001903.52717553
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.25414411
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.96499779
5Parkinsons disease_Homo sapiens_hsa050122.96435680
6Proteasome_Homo sapiens_hsa030502.73016296
7Protein export_Homo sapiens_hsa030602.66299408
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.63209412
9Linoleic acid metabolism_Homo sapiens_hsa005912.26759117
10Basal transcription factors_Homo sapiens_hsa030222.02746029
11Butanoate metabolism_Homo sapiens_hsa006502.00728321
12Alzheimers disease_Homo sapiens_hsa050101.95434085
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88264907
14Huntingtons disease_Homo sapiens_hsa050161.83886147
15Primary immunodeficiency_Homo sapiens_hsa053401.75241207
16Tryptophan metabolism_Homo sapiens_hsa003801.74205575
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70254145
18Cardiac muscle contraction_Homo sapiens_hsa042601.68528906
19Regulation of autophagy_Homo sapiens_hsa041401.66755822
20Steroid biosynthesis_Homo sapiens_hsa001001.63412156
21Ribosome_Homo sapiens_hsa030101.61878911
22Phototransduction_Homo sapiens_hsa047441.61423547
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55072669
24Nitrogen metabolism_Homo sapiens_hsa009101.46599938
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44266168
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43619359
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40937387
28Asthma_Homo sapiens_hsa053101.39221055
29Propanoate metabolism_Homo sapiens_hsa006401.37727828
30Chemical carcinogenesis_Homo sapiens_hsa052041.28910509
31Antigen processing and presentation_Homo sapiens_hsa046121.28271912
32Type I diabetes mellitus_Homo sapiens_hsa049401.28140309
33Graft-versus-host disease_Homo sapiens_hsa053321.26182241
34Autoimmune thyroid disease_Homo sapiens_hsa053201.24675248
35Nicotine addiction_Homo sapiens_hsa050331.19313119
36Allograft rejection_Homo sapiens_hsa053301.17218698
37Collecting duct acid secretion_Homo sapiens_hsa049661.14931049
38Peroxisome_Homo sapiens_hsa041461.11384485
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07084440
40RNA degradation_Homo sapiens_hsa030181.06612989
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.04935834
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.01352450
43RNA polymerase_Homo sapiens_hsa030200.92188910
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91324942
45Circadian rhythm_Homo sapiens_hsa047100.85765583
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.85085038
47Fanconi anemia pathway_Homo sapiens_hsa034600.84941441
48Ether lipid metabolism_Homo sapiens_hsa005650.83245963
49p53 signaling pathway_Homo sapiens_hsa041150.83138027
50Synaptic vesicle cycle_Homo sapiens_hsa047210.80500561
51Morphine addiction_Homo sapiens_hsa050320.79840663
52Arachidonic acid metabolism_Homo sapiens_hsa005900.78044219
53Retinol metabolism_Homo sapiens_hsa008300.77612509
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76624804
55Fat digestion and absorption_Homo sapiens_hsa049750.74831320
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74173272
57Sulfur metabolism_Homo sapiens_hsa009200.72450602
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71978554
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70576914
60Taste transduction_Homo sapiens_hsa047420.70492410
61Fatty acid elongation_Homo sapiens_hsa000620.67945734
62GABAergic synapse_Homo sapiens_hsa047270.67427959
63Metabolic pathways_Homo sapiens_hsa011000.66269813
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65313133
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64111079
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63967090
67beta-Alanine metabolism_Homo sapiens_hsa004100.63332536
68Sulfur relay system_Homo sapiens_hsa041220.61820735
69Homologous recombination_Homo sapiens_hsa034400.59385246
70Pyruvate metabolism_Homo sapiens_hsa006200.58518574
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57397458
72Pyrimidine metabolism_Homo sapiens_hsa002400.56720731
73Viral myocarditis_Homo sapiens_hsa054160.56263845
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.56243517
75ABC transporters_Homo sapiens_hsa020100.53264339
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52533211
77Rheumatoid arthritis_Homo sapiens_hsa053230.51572070
78Renin-angiotensin system_Homo sapiens_hsa046140.49377262
79Olfactory transduction_Homo sapiens_hsa047400.49084281
80Purine metabolism_Homo sapiens_hsa002300.48906770
81Salivary secretion_Homo sapiens_hsa049700.46453460
82Hedgehog signaling pathway_Homo sapiens_hsa043400.45153385
83Glutathione metabolism_Homo sapiens_hsa004800.44837029
84Fatty acid metabolism_Homo sapiens_hsa012120.43384162
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39900237
86Selenocompound metabolism_Homo sapiens_hsa004500.36860802
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36282773
88Glutamatergic synapse_Homo sapiens_hsa047240.35424012
89Starch and sucrose metabolism_Homo sapiens_hsa005000.34930239
90Systemic lupus erythematosus_Homo sapiens_hsa053220.34246144
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33906101
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.31509265
93Hematopoietic cell lineage_Homo sapiens_hsa046400.29930967
94Dopaminergic synapse_Homo sapiens_hsa047280.29435636
95Vibrio cholerae infection_Homo sapiens_hsa051100.28774559
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28588842
97Serotonergic synapse_Homo sapiens_hsa047260.28040832
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27858424
99Shigellosis_Homo sapiens_hsa051310.27196510
100Insulin secretion_Homo sapiens_hsa049110.25152566

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