IGDCC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)6.12393072
2embryonic foregut morphogenesis (GO:0048617)5.41637726
3DNA unwinding involved in DNA replication (GO:0006268)5.36131225
4cell proliferation involved in metanephros development (GO:0072203)5.29222933
5artery development (GO:0060840)5.10885040
6establishment of planar polarity (GO:0001736)5.09933939
7establishment of tissue polarity (GO:0007164)5.09933939
8lung epithelium development (GO:0060428)5.04493119
9lateral sprouting from an epithelium (GO:0060601)5.03391276
10dopaminergic neuron differentiation (GO:0071542)4.91698232
11negative regulation of DNA-templated transcription, elongation (GO:0032785)4.84117995
12negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.84117995
13G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.67771508
14lung-associated mesenchyme development (GO:0060484)4.61773929
15pre-miRNA processing (GO:0031054)4.53647897
16regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)4.42101111
17somite development (GO:0061053)4.39870226
18positive regulation of oligodendrocyte differentiation (GO:0048714)4.29789111
19planar cell polarity pathway involved in neural tube closure (GO:0090179)4.24312122
20negative regulation of smooth muscle cell differentiation (GO:0051151)4.23329984
21primitive streak formation (GO:0090009)4.18744111
22negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.12954410
23DNA strand elongation involved in DNA replication (GO:0006271)4.10956504
24mesenchymal cell proliferation (GO:0010463)4.07922634
25limb bud formation (GO:0060174)4.01212844
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.99181384
27regulation of mesenchymal cell apoptotic process (GO:2001053)3.96881401
28negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.96491733
29viral transcription (GO:0019083)3.95626099
30DNA strand elongation (GO:0022616)3.92561854
31lung lobe morphogenesis (GO:0060463)3.90583564
32axon extension involved in axon guidance (GO:0048846)3.88475915
33neuron projection extension involved in neuron projection guidance (GO:1902284)3.88475915
34regulation of non-canonical Wnt signaling pathway (GO:2000050)3.83170505
35translational termination (GO:0006415)3.82897415
36regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.80484395
37regulation of mesoderm development (GO:2000380)3.79983768
38negative regulation of axon guidance (GO:1902668)3.77186567
39branching involved in salivary gland morphogenesis (GO:0060445)3.70682874
40midbrain development (GO:0030901)3.69666487
41notochord development (GO:0030903)3.68593488
42pyrimidine nucleobase catabolic process (GO:0006208)3.67393247
43heterochromatin organization (GO:0070828)3.66703571
44cell proliferation involved in kidney development (GO:0072111)3.63892393
45thalamus development (GO:0021794)3.63172183
46astrocyte differentiation (GO:0048708)3.61189031
47telomere maintenance via semi-conservative replication (GO:0032201)3.55255085
48positive regulation of gastrulation (GO:2000543)3.54423509
49regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.52009233
50presynaptic membrane assembly (GO:0097105)3.51197605
51DNA replication initiation (GO:0006270)3.49522943
52myotube differentiation (GO:0014902)3.48749068
53spinal cord development (GO:0021510)3.45973024
54negative regulation of RNA splicing (GO:0033119)3.44654509
55renal system development (GO:0072001)3.44637810
56neuronal stem cell maintenance (GO:0097150)3.43783211
57negative regulation of axon extension involved in axon guidance (GO:0048843)3.42243209
58dorsal/ventral neural tube patterning (GO:0021904)3.41370483
59negative regulation of mRNA processing (GO:0050686)3.39107166
60ribosomal small subunit assembly (GO:0000028)3.36726699
61peptidyl-arginine omega-N-methylation (GO:0035247)3.35207728
62cell proliferation in forebrain (GO:0021846)3.32404925
63translesion synthesis (GO:0019985)3.25966318
64mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.25033721
65kinetochore organization (GO:0051383)3.21749156
66DNA replication checkpoint (GO:0000076)3.21367622
67regulation of sister chromatid cohesion (GO:0007063)3.17151104
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.15941523
69presynaptic membrane organization (GO:0097090)3.14012480
70embryonic hindlimb morphogenesis (GO:0035116)3.13994329
71cotranslational protein targeting to membrane (GO:0006613)3.13364785
72cochlea morphogenesis (GO:0090103)3.13119985
73negative regulation of astrocyte differentiation (GO:0048712)3.12804657
74DNA replication-dependent nucleosome assembly (GO:0006335)3.12627254
75DNA replication-dependent nucleosome organization (GO:0034723)3.12627254
76mitotic recombination (GO:0006312)3.12059945
77protein localization to kinetochore (GO:0034501)3.11491186
78positive regulation of neuroblast proliferation (GO:0002052)3.07739409
79positive regulation of embryonic development (GO:0040019)3.06636595
80protein targeting to ER (GO:0045047)3.06486705
81post-anal tail morphogenesis (GO:0036342)3.06056532
82translational elongation (GO:0006414)3.06022581
83telomere maintenance via recombination (GO:0000722)3.05945113
84face development (GO:0060324)3.05002156
85kinetochore assembly (GO:0051382)3.02886778
86pituitary gland development (GO:0021983)3.02438235
87nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02270027
88hindlimb morphogenesis (GO:0035137)3.01365471
89cranial nerve development (GO:0021545)2.99265427
90lens fiber cell development (GO:0070307)2.97558126
91nucleosome disassembly (GO:0006337)2.97361464
92protein-DNA complex disassembly (GO:0032986)2.97361464
93cellular protein complex disassembly (GO:0043624)2.95784827
94negative regulation of glial cell differentiation (GO:0045686)2.95526581
95behavioral response to nicotine (GO:0035095)2.94071482
96DNA strand renaturation (GO:0000733)2.93551434
97establishment of protein localization to endoplasmic reticulum (GO:0072599)2.93322246
98histone arginine methylation (GO:0034969)2.92176962
99CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.91875636
100peptidyl-arginine methylation (GO:0018216)2.91004317
101peptidyl-arginine N-methylation (GO:0035246)2.91004317
102retinal ganglion cell axon guidance (GO:0031290)2.90216763
103regulation of oligodendrocyte differentiation (GO:0048713)2.89896238
104epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.89307180
105nucleotide-excision repair, DNA gap filling (GO:0006297)2.87839389
106positive regulation of T cell differentiation in thymus (GO:0033089)2.86640185
107protein complex disassembly (GO:0043241)2.86605435
108establishment of integrated proviral latency (GO:0075713)2.85917766
109midgut development (GO:0007494)2.85456438
110Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.84093416
111cell surface receptor signaling pathway involved in heart development (GO:0061311)2.84042293
112regulation of organ formation (GO:0003156)2.83756828
113mitotic metaphase plate congression (GO:0007080)2.83462990
114regulation of gene silencing by RNA (GO:0060966)2.82822576
115regulation of posttranscriptional gene silencing (GO:0060147)2.82822576
116regulation of gene silencing by miRNA (GO:0060964)2.82822576
117hindbrain development (GO:0030902)2.82709942
118deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.81106921
119kidney morphogenesis (GO:0060993)2.80675379
120protein localization to endoplasmic reticulum (GO:0070972)2.79721323
121convergent extension (GO:0060026)2.79659212
122telomere maintenance via telomere lengthening (GO:0010833)2.79363912
123sister chromatid segregation (GO:0000819)2.78800659
124viral life cycle (GO:0019058)2.78348600
125postsynaptic membrane organization (GO:0001941)2.77092500
126DNA replication-independent nucleosome assembly (GO:0006336)2.76918466
127DNA replication-independent nucleosome organization (GO:0034724)2.76918466
128regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.75496258
129urogenital system development (GO:0001655)2.75133525
130regulation of establishment of planar polarity (GO:0090175)2.74892911
131maturation of SSU-rRNA (GO:0030490)2.74074324
132CENP-A containing nucleosome assembly (GO:0034080)2.73322337
133neuron fate determination (GO:0048664)2.72235169
134DNA damage response, detection of DNA damage (GO:0042769)2.72171940
135non-canonical Wnt signaling pathway (GO:0035567)2.72148497
136short-term memory (GO:0007614)2.72004607
137cellular response to cholesterol (GO:0071397)2.70746190
138ribosomal small subunit biogenesis (GO:0042274)2.69637308
139dorsal/ventral axis specification (GO:0009950)2.69333434
140regulation of stem cell maintenance (GO:2000036)2.67818223
141macromolecular complex disassembly (GO:0032984)2.66112363
142nucleobase catabolic process (GO:0046113)2.65705072
143axon ensheathment in central nervous system (GO:0032291)2.65217895
144central nervous system myelination (GO:0022010)2.65217895
145forebrain neuron differentiation (GO:0021879)2.62849745
146outer ear morphogenesis (GO:0042473)2.62453536
147regulation of growth hormone secretion (GO:0060123)2.61691689
148otic vesicle formation (GO:0030916)2.58917325
149establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.58202222
150nonmotile primary cilium assembly (GO:0035058)2.55540213
151spinal cord association neuron differentiation (GO:0021527)2.53901074
152chromatin remodeling at centromere (GO:0031055)2.53823062
153peristalsis (GO:0030432)2.52553426
154cell migration in hindbrain (GO:0021535)2.50332636
155translational initiation (GO:0006413)2.48680666
156mesenchymal to epithelial transition (GO:0060231)2.46867226
157protein localization to synapse (GO:0035418)2.46822914
158nephron tubule morphogenesis (GO:0072078)2.46491748
159nephron epithelium morphogenesis (GO:0072088)2.46491748
160somatic stem cell division (GO:0048103)2.46240406
161axonal fasciculation (GO:0007413)2.44476607
162regulation of translation, ncRNA-mediated (GO:0045974)2.42590786
163negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42590786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.59533170
2EZH2_22144423_ChIP-Seq_EOC_Human4.64211470
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.88310117
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.69823816
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.60636276
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.58747215
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.42058498
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.87984601
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.78330487
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.57061195
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49798099
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45918988
13XRN2_22483619_ChIP-Seq_HELA_Human2.44036524
14AR_21909140_ChIP-Seq_LNCAP_Human2.43990042
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29939951
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27593451
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17412925
18SOX2_18555785_ChIP-Seq_MESCs_Mouse2.05561422
19KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.02634333
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00853664
21E2F7_22180533_ChIP-Seq_HELA_Human10.1727979
22CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.99262195
23TTF2_22483619_ChIP-Seq_HELA_Human1.97828849
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96655567
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92298069
26RNF2_27304074_Chip-Seq_NSC_Mouse1.88304868
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87634164
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85637239
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79368575
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76234370
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76231589
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76227235
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72253986
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.71563413
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61991417
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.61419944
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61070359
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.60389724
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59187753
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59187753
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58232007
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.57826578
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.57457764
44SOX2_16153702_ChIP-ChIP_HESCs_Human1.55703705
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53641378
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53641378
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52951069
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52951069
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52951069
50RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.51749530
51ZNF274_21170338_ChIP-Seq_K562_Hela1.51251248
52CIITA_25753668_ChIP-Seq_RAJI_Human1.51058489
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50986130
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50956833
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.49930540
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.49863549
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49600683
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46959342
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44958374
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44418918
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43215783
62MYC_22102868_ChIP-Seq_BL_Human1.40843578
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40602884
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.40367830
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39692705
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39025908
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.37668884
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37431341
69* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36097181
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35831338
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.34894803
72FUS_26573619_Chip-Seq_HEK293_Human1.34342945
73VDR_22108803_ChIP-Seq_LS180_Human1.34285882
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32081546
75CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31111311
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.30669202
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.29787507
78NANOG_16153702_ChIP-ChIP_HESCs_Human1.28569653
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.27469913
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27092491
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25724410
82TCF3_18692474_ChIP-Seq_MESCs_Mouse1.25146057
83REST_21632747_ChIP-Seq_MESCs_Mouse1.24390002
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23547268
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23348953
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23247451
87* EZH2_27294783_Chip-Seq_ESCs_Mouse1.21387625
88EWS_26573619_Chip-Seq_HEK293_Human1.19902378
89SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.19707852
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19305743
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18735669
92* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18708736
93SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18640865
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18373224
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18165860
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18010210
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15614593
98DCP1A_22483619_ChIP-Seq_HELA_Human1.14417005
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.12948204
100POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.11945486
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11561126
102POU5F1_16518401_ChIP-PET_MESCs_Mouse1.10909427
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09329968
104GABP_19822575_ChIP-Seq_HepG2_Human1.08921858
105SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08784440
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07824658
107SALL1_21062744_ChIP-ChIP_HESCs_Human1.07300934
108EZH2_27304074_Chip-Seq_ESCs_Mouse1.06739280
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06332859
110JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06195063
111REST_18959480_ChIP-ChIP_MESCs_Mouse1.05609043
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05528504
113PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05525629
114NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04731100
115GABP_17652178_ChIP-ChIP_JURKAT_Human1.04509853
116TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03078369
117TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02555652
118SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00483068
119TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99311862
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99280858
121STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97710242
122FOXP3_21729870_ChIP-Seq_TREG_Human0.97380753
123P300_19829295_ChIP-Seq_ESCs_Human0.97360562
124SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97317370
125SOX9_26525672_Chip-Seq_HEART_Mouse0.96767606
126CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96261529
127SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96171410
128IRF1_19129219_ChIP-ChIP_H3396_Human0.95742564
129NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95489314
130EED_16625203_ChIP-ChIP_MESCs_Mouse0.94423603
131SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93729001
132OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93607072
133RING1B_27294783_Chip-Seq_NPCs_Mouse0.93302865
134KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93053162
135STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92290725
136NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91030552
137E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90923610
138PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89749236
139ISL1_27105846_Chip-Seq_CPCs_Mouse0.89510798
140MYC_18940864_ChIP-ChIP_HL60_Human0.88051398
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88033727
142CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87324818
143HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86536724
144KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86132630
145WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86099736
146DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84204144
147PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84098507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ5.83596547
2MP0009053_abnormal_anal_canal4.46644586
3MP0000566_synostosis3.98155878
4MP0010030_abnormal_orbit_morphology3.93054918
5MP0002653_abnormal_ependyma_morphology3.73284480
6MP0000537_abnormal_urethra_morphology3.58014153
7MP0002102_abnormal_ear_morphology3.50690285
8MP0002234_abnormal_pharynx_morphology3.44860603
9MP0003136_yellow_coat_color2.67669271
10MP0003122_maternal_imprinting2.65329247
11MP0002282_abnormal_trachea_morphology2.49655537
12MP0003119_abnormal_digestive_system2.30407244
13MP0003121_genomic_imprinting2.21067310
14MP0010094_abnormal_chromosome_stability2.14657609
15MP0003315_abnormal_perineum_morphology2.14249437
16MP0003938_abnormal_ear_development2.13224346
17MP0008057_abnormal_DNA_replication2.07219265
18MP0009379_abnormal_foot_pigmentation2.04770822
19MP0003111_abnormal_nucleus_morphology2.02588099
20MP0001293_anophthalmia2.02236110
21MP0002932_abnormal_joint_morphology2.01666256
22MP0003937_abnormal_limbs/digits/tail_de1.95465343
23MP0003077_abnormal_cell_cycle1.92265332
24MP0003123_paternal_imprinting1.92140130
25MP0003693_abnormal_embryo_hatching1.88795994
26MP0003890_abnormal_embryonic-extraembry1.88122818
27MP0004957_abnormal_blastocyst_morpholog1.87311366
28MP0008932_abnormal_embryonic_tissue1.82624532
29MP0000383_abnormal_hair_follicle1.79324765
30MP0001529_abnormal_vocalization1.78201587
31MP0003115_abnormal_respiratory_system1.76961087
32MP0003878_abnormal_ear_physiology1.75791479
33MP0005377_hearing/vestibular/ear_phenot1.75791479
34MP0004133_heterotaxia1.69093719
35MP0000778_abnormal_nervous_system1.68280483
36MP0002938_white_spotting1.64756853
37MP0000049_abnormal_middle_ear1.61911433
38MP0002085_abnormal_embryonic_tissue1.58474033
39MP0002822_catalepsy1.58445945
40MP0002249_abnormal_larynx_morphology1.55700673
41MP0002751_abnormal_autonomic_nervous1.52155376
42MP0002084_abnormal_developmental_patter1.51304160
43MP0005076_abnormal_cell_differentiation1.50852439
44MP0000428_abnormal_craniofacial_morphol1.50842616
45MP0008007_abnormal_cellular_replicative1.43025106
46MP0002697_abnormal_eye_size1.42585388
47MP0000462_abnormal_digestive_system1.42271414
48MP0006292_abnormal_olfactory_placode1.42189551
49MP0004233_abnormal_muscle_weight1.41781352
50MP0002233_abnormal_nose_morphology1.40539981
51MP0002111_abnormal_tail_morphology1.38031929
52MP0004197_abnormal_fetal_growth/weight/1.36879383
53MP0008789_abnormal_olfactory_epithelium1.36360052
54MP0003861_abnormal_nervous_system1.36262173
55MP0000350_abnormal_cell_proliferation1.35122623
56MP0001346_abnormal_lacrimal_gland1.34978853
57MP0001730_embryonic_growth_arrest1.34489215
58MP0003880_abnormal_central_pattern1.34394010
59MP0001299_abnormal_eye_distance/1.33286986
60MP0002116_abnormal_craniofacial_bone1.32770455
61MP0003787_abnormal_imprinting1.32277161
62MP0002092_abnormal_eye_morphology1.30741609
63MP0000467_abnormal_esophagus_morphology1.29927326
64MP0003942_abnormal_urinary_system1.25707004
65MP0005380_embryogenesis_phenotype1.25388480
66MP0001672_abnormal_embryogenesis/_devel1.25388480
67MP0001286_abnormal_eye_development1.24458006
68MP0008058_abnormal_DNA_repair1.23989088
69MP0010678_abnormal_skin_adnexa1.23255278
70MP0006276_abnormal_autonomic_nervous1.22797133
71MP0003385_abnormal_body_wall1.20970105
72MP0003755_abnormal_palate_morphology1.14313552
73MP0002184_abnormal_innervation1.12765337
74MP0003984_embryonic_growth_retardation1.11491292
75MP0003935_abnormal_craniofacial_develop1.11309442
76MP0005499_abnormal_olfactory_system1.10519146
77MP0005394_taste/olfaction_phenotype1.10519146
78MP0002088_abnormal_embryonic_growth/wei1.10392817
79MP0009250_abnormal_appendicular_skeleto1.10046675
80MP0005646_abnormal_pituitary_gland1.08433534
81MP0001697_abnormal_embryo_size1.07888541
82MP0001485_abnormal_pinna_reflex1.07859062
83MP0005257_abnormal_intraocular_pressure1.02485032
84MP0004742_abnormal_vestibular_system0.99380787
85MP0002098_abnormal_vibrissa_morphology0.99213945
86MP0004885_abnormal_endolymph0.98442411
87MP0002752_abnormal_somatic_nervous0.97921629
88MP0009672_abnormal_birth_weight0.97900086
89MP0000026_abnormal_inner_ear0.97336788
90MP0002557_abnormal_social/conspecific_i0.97307262
91MP0005503_abnormal_tendon_morphology0.97038919
92MP0006072_abnormal_retinal_apoptosis0.94290188
93MP0001984_abnormal_olfaction0.92750513
94MP0008961_abnormal_basal_metabolism0.92571140
95MP0000432_abnormal_head_morphology0.90745422
96MP0005195_abnormal_posterior_eye0.90279441
97MP0004134_abnormal_chest_morphology0.89405203
98MP0000631_abnormal_neuroendocrine_gland0.88828268
99MP0002114_abnormal_axial_skeleton0.87895489
100MP0003011_delayed_dark_adaptation0.87111228
101MP0005248_abnormal_Harderian_gland0.86473960
102MP0002080_prenatal_lethality0.85397271
103MP0003941_abnormal_skin_development0.83979785
104MP0004142_abnormal_muscle_tone0.82874491
105MP0002882_abnormal_neuron_morphology0.81857483
106MP0000579_abnormal_nail_morphology0.80776090
107MP0000534_abnormal_ureter_morphology0.80757642
108MP0005423_abnormal_somatic_nervous0.80286354
109MP0000762_abnormal_tongue_morphology0.77677242
110MP0002109_abnormal_limb_morphology0.76240756
111MP0005391_vision/eye_phenotype0.76230122
112MP0009703_decreased_birth_body0.75785895
113MP0002081_perinatal_lethality0.74486952
114MP0003567_abnormal_fetal_cardiomyocyte0.74435684
115MP0001915_intracranial_hemorrhage0.73381037
116MP0002638_abnormal_pupillary_reflex0.73245237
117MP0008877_abnormal_DNA_methylation0.73221072
118MP0001324_abnormal_eye_pigmentation0.72596583
119MP0005187_abnormal_penis_morphology0.71851742
120MP0002086_abnormal_extraembryonic_tissu0.71398205
121MP0005508_abnormal_skeleton_morphology0.70771093
122MP0002152_abnormal_brain_morphology0.70732265
123MP0000733_abnormal_muscle_development0.70618461
124MP0005253_abnormal_eye_physiology0.70468698
125MP0001188_hyperpigmentation0.69047864
126MP0004858_abnormal_nervous_system0.68788149
127MP0002909_abnormal_adrenal_gland0.68274665
128MP0001340_abnormal_eyelid_morphology0.68011728
129MP0002177_abnormal_outer_ear0.65436824
130MP0000613_abnormal_salivary_gland0.64850098
131MP0002089_abnormal_postnatal_growth/wei0.64033001
132MP0000955_abnormal_spinal_cord0.62300258
133MP0000163_abnormal_cartilage_morphology0.58065877

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of incisors (HP:0011064)5.86242678
2Bilateral microphthalmos (HP:0007633)5.54723559
3Anophthalmia (HP:0000528)4.16048979
4Renal duplication (HP:0000075)4.12621559
5Short middle phalanx of the 5th finger (HP:0004220)3.66167011
6Maternal diabetes (HP:0009800)3.65671634
7Concave nail (HP:0001598)3.57023142
8Reticulocytopenia (HP:0001896)3.37018976
9Tented upper lip vermilion (HP:0010804)3.29864311
10Bifid tongue (HP:0010297)3.13739353
11Patellar aplasia (HP:0006443)3.09287051
12Aplasia/Hypoplasia of the patella (HP:0006498)3.04250032
13Intestinal atresia (HP:0011100)2.98648189
14Preaxial foot polydactyly (HP:0001841)2.98349495
15Hepatoblastoma (HP:0002884)2.92505627
16Abnormality of chromosome segregation (HP:0002916)2.86478251
17Midline defect of the nose (HP:0004122)2.83910589
18Short 5th finger (HP:0009237)2.81084344
19Abnormality of the incisor (HP:0000676)2.78966886
20Growth hormone deficiency (HP:0000824)2.71777388
21Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.70973687
22High anterior hairline (HP:0009890)2.65069881
23Vitreoretinal degeneration (HP:0000655)2.62655903
24Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.61437894
25Mesomelia (HP:0003027)2.58571787
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.57363941
27Short 4th metacarpal (HP:0010044)2.57363941
28Triphalangeal thumb (HP:0001199)2.56585561
29Abnormality of the duodenum (HP:0002246)2.55308471
30Ependymoma (HP:0002888)2.55121976
31Small intestinal stenosis (HP:0012848)2.54079880
32Duodenal stenosis (HP:0100867)2.54079880
33Narrow nasal bridge (HP:0000446)2.49566658
34Myelomeningocele (HP:0002475)2.49403378
35Medulloblastoma (HP:0002885)2.47919560
36Duplication of thumb phalanx (HP:0009942)2.45666416
37Absent radius (HP:0003974)2.45052305
38Absent septum pellucidum (HP:0001331)2.45049144
39Hypoplastic labia majora (HP:0000059)2.44113824
40Oligodactyly (HP:0012165)2.40829912
41Rib fusion (HP:0000902)2.40624309
42Hypoplastic pelvis (HP:0008839)2.40310903
43Aplasia involving forearm bones (HP:0009822)2.39796495
44Absent forearm bone (HP:0003953)2.39796495
45Septo-optic dysplasia (HP:0100842)2.38914117
46Cutaneous finger syndactyly (HP:0010554)2.38324251
47Megalencephaly (HP:0001355)2.36427786
48Optic nerve hypoplasia (HP:0000609)2.34642284
49Broad toe (HP:0001837)2.34567805
50Esophageal atresia (HP:0002032)2.34249518
51Abnormality of the pubic bones (HP:0003172)2.33957706
52Ectopic kidney (HP:0000086)2.32637364
53Increased nuchal translucency (HP:0010880)2.31610083
54Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.31144288
55Renal hypoplasia (HP:0000089)2.28564868
56Broad thumb (HP:0011304)2.28459143
57Aplasia of the musculature (HP:0100854)2.27695967
58Anal stenosis (HP:0002025)2.23166295
59Colon cancer (HP:0003003)2.22970546
60Abnormality of the labia majora (HP:0012881)2.22369149
61Labial hypoplasia (HP:0000066)2.21514363
62Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.19911843
63Absent epiphyses (HP:0010577)2.19911843
64Trigonocephaly (HP:0000243)2.19724633
65Cutaneous syndactyly (HP:0012725)2.19655892
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.19175471
67Aplasia/Hypoplasia involving the musculature (HP:0001460)2.18643773
68Abnormality of abdominal situs (HP:0011620)2.18235317
69Abdominal situs inversus (HP:0003363)2.18235317
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17554821
71Synostosis of carpal bones (HP:0005048)2.16831883
72Skull defect (HP:0001362)2.16142156
73Irregular epiphyses (HP:0010582)2.15558473
74Preaxial hand polydactyly (HP:0001177)2.15506542
75Abnormality of the lacrimal duct (HP:0011481)2.14933486
76Supernumerary ribs (HP:0005815)2.13396659
77Hemivertebrae (HP:0002937)2.12310337
78Broad phalanges of the hand (HP:0009768)2.12162007
79Partial duplication of the phalanx of hand (HP:0009999)2.10768180
80Carpal synostosis (HP:0009702)2.08265342
81Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.08188483
82Meckel diverticulum (HP:0002245)2.05085093
83Hypoplastic female external genitalia (HP:0012815)2.04639584
84Supernumerary bones of the axial skeleton (HP:0009144)2.04577943
85Oligodactyly (hands) (HP:0001180)2.04137334
86Hyperglycinemia (HP:0002154)2.03626700
87Broad finger (HP:0001500)2.03370775
88Abnormal lung lobation (HP:0002101)2.03085022
89Abnormality of the phalanges of the 2nd finger (HP:0009541)2.02679243
90Rectal fistula (HP:0100590)2.02220128
91Rectovaginal fistula (HP:0000143)2.02220128
92Gastrointestinal atresia (HP:0002589)2.01713667
93Abnormality of the radial head (HP:0003995)2.00114044
94Abnormality of the ileum (HP:0001549)1.99863718
95Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.99084456
96Abnormality of the parietal bone (HP:0002696)1.98381941
97Anosmia (HP:0000458)1.98335781
98Abnormality of the septum pellucidum (HP:0007375)1.98052228
99Synostosis involving the elbow (HP:0003938)1.97668534
100Humeroradial synostosis (HP:0003041)1.97668534
101Abnormality of the anterior horn cell (HP:0006802)1.97537953
102Degeneration of anterior horn cells (HP:0002398)1.97537953
103Macrocytic anemia (HP:0001972)1.97469394
104Vaginal fistula (HP:0004320)1.96957537
105Abnormality of the right ventricle (HP:0001707)1.96697493
106Broad distal phalanx of finger (HP:0009836)1.95965970
107Abnormality of the aortic arch (HP:0012303)1.95420737
108Meningocele (HP:0002435)1.95324323
109Abnormality of the upper arm (HP:0001454)1.94942105
110Selective tooth agenesis (HP:0001592)1.94841944
111Porencephaly (HP:0002132)1.94700345
112Patellar dislocation (HP:0002999)1.94402124
113Long eyelashes (HP:0000527)1.93178510
114Abnormality of cells of the erythroid lineage (HP:0012130)1.90932157
115Hypoplasia of the ulna (HP:0003022)1.90222212
116Aqueductal stenosis (HP:0002410)1.89945606
117Abnormal number of erythroid precursors (HP:0012131)1.89509304
118Choanal stenosis (HP:0000452)1.89166253
119Abnormality of the labia minora (HP:0012880)1.88593317
120Ridged nail (HP:0001807)1.88252042
121Abnormality of the nasolacrimal system (HP:0000614)1.87596869
122Abnormality of the 4th metacarpal (HP:0010012)1.86949014
123Abnormality of the middle phalanges of the toes (HP:0010183)1.86899904
124Hydronephrosis (HP:0000126)1.86457429
125Morphological abnormality of the inner ear (HP:0011390)1.86453154
126Neoplasm of striated muscle (HP:0009728)1.86110941
127Horseshoe kidney (HP:0000085)1.86076265
128Scrotal hypoplasia (HP:0000046)1.85876531
129Mixed hearing impairment (HP:0000410)1.85751674
130Broad palm (HP:0001169)1.85646923
131Carpal bone hypoplasia (HP:0001498)1.84679185
132Aplasia/Hypoplasia of the sternum (HP:0006714)1.83732989
133Broad alveolar ridges (HP:0000187)1.82362510
134Abnormality of the phalanges of the 5th finger (HP:0004213)1.81698039
135Morphological abnormality of the middle ear (HP:0008609)1.81673155
136Partial duplication of thumb phalanx (HP:0009944)1.80990739
137Supernumerary spleens (HP:0009799)1.79996026
138Glioma (HP:0009733)1.79698950
139Choanal atresia (HP:0000453)1.78052432
140Increased number of teeth (HP:0011069)1.77851064
141Limited elbow extension (HP:0001377)1.76272532
142Broad phalanx (HP:0006009)1.75974113
143Astrocytoma (HP:0009592)1.75355395
144Abnormality of the astrocytes (HP:0100707)1.75355395
145Tetralogy of Fallot (HP:0001636)1.74207127
146Holoprosencephaly (HP:0001360)1.73880796
147Aplasia involving bones of the extremities (HP:0009825)1.73618850
148Aplasia involving bones of the upper limbs (HP:0009823)1.73618850
149Aplasia of the phalanges of the hand (HP:0009802)1.73618850
150Coronal craniosynostosis (HP:0004440)1.73480674
151Atresia of the external auditory canal (HP:0000413)1.73195470
15211 pairs of ribs (HP:0000878)1.70383811
153Diastasis recti (HP:0001540)1.70067554
154Chromosomal breakage induced by crosslinking agents (HP:0003221)1.67358821
155Intestinal fistula (HP:0100819)1.66640379
156Bicornuate uterus (HP:0000813)1.66599405
157Aplasia/Hypoplasia of the ulna (HP:0006495)1.66234433
158Epiphyseal dysplasia (HP:0002656)1.66221095
159Down-sloping shoulders (HP:0200021)1.65906744

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.67187612
2PASK4.56934390
3KSR14.13987060
4CDC73.98729159
5BUB13.57411595
6SIK32.98386406
7WEE12.58648607
8MAP3K102.52383261
9MKNK12.43441382
10VRK22.40684995
11CDK122.39391471
12BCR2.28458477
13SRPK12.25289721
14CASK2.25255655
15ICK1.98830560
16NEK21.91099915
17TAF11.86308775
18WNK31.80795398
19BRD41.79779308
20TGFBR11.77951305
21ERBB21.76910165
22TSSK61.76909502
23FGFR21.75686464
24TNIK1.72480154
25UHMK11.70120550
26EPHA41.69845360
27PAK41.62933645
28DYRK31.54249900
29CDK71.52150473
30NEK11.50310288
31MARK11.49450818
32TTK1.45456692
33MELK1.38333952
34PLK11.38058296
35CCNB11.36259056
36ATR1.33565455
37BRSK11.32382978
38PLK31.31109602
39FGFR41.30417057
40MAP3K41.30335925
41PNCK1.27815158
42EIF2AK11.24794588
43WNK41.23403141
44AURKB1.23086079
45NME11.20043240
46LATS21.19917441
47NTRK11.16122733
48FGFR11.15516204
49CHEK11.13860538
50LATS11.09173321
51MKNK21.01004137
52MINK10.98906854
53ACVR1B0.97374123
54AURKA0.97259764
55PRKCG0.95009175
56TYRO30.93612020
57CHEK20.93577593
58TRIM280.90126284
59ZAK0.89555559
60AKT20.89237564
61CAMK1G0.87834461
62FGFR30.85695551
63NUAK10.85201996
64TLK10.84908672
65MAPK150.84486001
66NTRK30.83991664
67ERBB30.83742265
68BRSK20.83622497
69CDK80.82881002
70YES10.82231942
71CSNK1G10.77997367
72RPS6KA40.76445393
73IRAK20.76130026
74DDR20.75905300
75CDK20.75185257
76CSNK1G20.73723315
77SGK2230.73310533
78SGK4940.73310533
79CDK40.72820822
80ADRBK20.72678200
81CDK180.72531532
82CDK10.68522694
83MAP2K70.67084129
84MTOR0.67020167
85MAP3K80.65937766
86CAMK1D0.65072915
87PLK20.64640167
88TESK20.64407553
89PDGFRA0.59189924
90PLK40.58962561
91MAPK130.57656989
92CSNK1A1L0.56084956
93BMPR1B0.55435641
94CDK150.54967859
95CDK140.54704696
96CDK60.54660469
97TIE10.54348955
98DYRK1B0.53594853
99GRK10.53248049
100CDK11A0.52984020
101DYRK1A0.51873945
102STK390.49200118
103ATM0.49090874
104DYRK20.49045441
105WNK10.46745080
106CSNK1D0.46404918
107CSNK1E0.45765628
108TAOK20.45149450
109STK110.43883343
110EIF2AK20.42251455
111SIK20.42147283
112SGK20.40593408
113STK30.40067808
114CDK30.40040054
115SIK10.39573828
116MAP4K20.39247721
117VRK10.38501817
118ROCK20.37796081
119AKT10.37783839
120PAK20.37725829
121TRIB30.36453051
122CDK190.34852625
123ALK0.34290467
124STK38L0.33792783
125CSNK2A10.33154557
126PAK10.32198344
127RPS6KA10.32124156
128PRKD30.31851240
129NTRK20.31259952
130STK160.31208403
131CSNK2A20.29060544
132PTK60.27620022
133CSNK1G30.27600022
134EEF2K0.26835622
135CDK90.25586528
136DMPK0.23818916
137MAPK100.22701961
138PRKDC0.22497818
139MAPK90.22332977
140MAPK140.22013337

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.15939005
2Basal cell carcinoma_Homo sapiens_hsa052174.83395041
3Spliceosome_Homo sapiens_hsa030403.97899586
4Mismatch repair_Homo sapiens_hsa034303.88718088
5Hedgehog signaling pathway_Homo sapiens_hsa043403.76141339
6Cell cycle_Homo sapiens_hsa041103.24526547
7Base excision repair_Homo sapiens_hsa034103.02598686
8Homologous recombination_Homo sapiens_hsa034402.80192557
9RNA transport_Homo sapiens_hsa030132.77540483
10Hippo signaling pathway_Homo sapiens_hsa043902.76043378
11mRNA surveillance pathway_Homo sapiens_hsa030152.54878126
12Notch signaling pathway_Homo sapiens_hsa043302.47572877
13Nucleotide excision repair_Homo sapiens_hsa034202.22500416
14Oxidative phosphorylation_Homo sapiens_hsa001902.02797185
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.98646146
16Parkinsons disease_Homo sapiens_hsa050121.95624728
17Wnt signaling pathway_Homo sapiens_hsa043101.87516798
18Fanconi anemia pathway_Homo sapiens_hsa034601.83132810
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80712481
20Pyrimidine metabolism_Homo sapiens_hsa002401.80472204
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77296911
22One carbon pool by folate_Homo sapiens_hsa006701.68850545
23Protein export_Homo sapiens_hsa030601.66786126
24Melanogenesis_Homo sapiens_hsa049161.65987909
25Huntingtons disease_Homo sapiens_hsa050161.62576907
26Oocyte meiosis_Homo sapiens_hsa041141.60895556
27RNA polymerase_Homo sapiens_hsa030201.53963088
28MicroRNAs in cancer_Homo sapiens_hsa052061.53431450
29Ribosome_Homo sapiens_hsa030101.52716703
30Cardiac muscle contraction_Homo sapiens_hsa042601.47883751
31Proteasome_Homo sapiens_hsa030501.44149038
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40681216
33RNA degradation_Homo sapiens_hsa030181.36899130
34Nicotine addiction_Homo sapiens_hsa050331.33543943
35HTLV-I infection_Homo sapiens_hsa051661.28464046
36p53 signaling pathway_Homo sapiens_hsa041151.25975521
37Vitamin digestion and absorption_Homo sapiens_hsa049771.23914042
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23085058
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20863005
40Fat digestion and absorption_Homo sapiens_hsa049751.20241744
41Axon guidance_Homo sapiens_hsa043601.19171892
42Alzheimers disease_Homo sapiens_hsa050101.10991588
43TGF-beta signaling pathway_Homo sapiens_hsa043501.08928894
44Basal transcription factors_Homo sapiens_hsa030221.08091886
45Non-homologous end-joining_Homo sapiens_hsa034501.05086137
46Systemic lupus erythematosus_Homo sapiens_hsa053220.97025127
47Colorectal cancer_Homo sapiens_hsa052100.94751246
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94540603
49Lysine degradation_Homo sapiens_hsa003100.94224266
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94150470
51Phototransduction_Homo sapiens_hsa047440.92910225
52Proteoglycans in cancer_Homo sapiens_hsa052050.92817481
53Pathways in cancer_Homo sapiens_hsa052000.92756251
54Butanoate metabolism_Homo sapiens_hsa006500.91175963
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88350889
56Adherens junction_Homo sapiens_hsa045200.87547116
57Purine metabolism_Homo sapiens_hsa002300.87089944
58Biosynthesis of amino acids_Homo sapiens_hsa012300.87087875
59Bladder cancer_Homo sapiens_hsa052190.86778172
60Epstein-Barr virus infection_Homo sapiens_hsa051690.83406195
61Propanoate metabolism_Homo sapiens_hsa006400.77020369
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76540483
63Fatty acid metabolism_Homo sapiens_hsa012120.75649343
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74948700
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74293986
66Viral carcinogenesis_Homo sapiens_hsa052030.74208548
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.74105830
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72344610
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70200375
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67213636
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67038578
72Cocaine addiction_Homo sapiens_hsa050300.67005026
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66771550
74Chronic myeloid leukemia_Homo sapiens_hsa052200.64213674
75Sulfur relay system_Homo sapiens_hsa041220.64159702
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63883141
77Taste transduction_Homo sapiens_hsa047420.63385853
78Tight junction_Homo sapiens_hsa045300.62216302
79GABAergic synapse_Homo sapiens_hsa047270.59848846
80Fatty acid biosynthesis_Homo sapiens_hsa000610.58805113
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58593620
82Small cell lung cancer_Homo sapiens_hsa052220.58026996
83Nitrogen metabolism_Homo sapiens_hsa009100.57165275
84Alcoholism_Homo sapiens_hsa050340.55860364
85Glutamatergic synapse_Homo sapiens_hsa047240.52516697
86Viral myocarditis_Homo sapiens_hsa054160.52481536
87Morphine addiction_Homo sapiens_hsa050320.52257759
88Herpes simplex infection_Homo sapiens_hsa051680.52132115
89Folate biosynthesis_Homo sapiens_hsa007900.50700514
90Thyroid cancer_Homo sapiens_hsa052160.46775922
91Metabolic pathways_Homo sapiens_hsa011000.45626695
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45146875
93Pyruvate metabolism_Homo sapiens_hsa006200.44310802
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42779413
95Endometrial cancer_Homo sapiens_hsa052130.42674716
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41730549
97Non-small cell lung cancer_Homo sapiens_hsa052230.41581851
98Peroxisome_Homo sapiens_hsa041460.41232067
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39625556
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39385269
101Complement and coagulation cascades_Homo sapiens_hsa046100.39282496
102Ether lipid metabolism_Homo sapiens_hsa005650.38401302
103Prostate cancer_Homo sapiens_hsa052150.37139152
104Carbon metabolism_Homo sapiens_hsa012000.36903189
105Dopaminergic synapse_Homo sapiens_hsa047280.36068066
106Renal cell carcinoma_Homo sapiens_hsa052110.35827860
107mTOR signaling pathway_Homo sapiens_hsa041500.35792247
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35362951
109N-Glycan biosynthesis_Homo sapiens_hsa005100.35104879
110Retinol metabolism_Homo sapiens_hsa008300.34803251
111Protein digestion and absorption_Homo sapiens_hsa049740.34385306
112Linoleic acid metabolism_Homo sapiens_hsa005910.34384743
113ECM-receptor interaction_Homo sapiens_hsa045120.32331305
114Gap junction_Homo sapiens_hsa045400.32009944
115Glycerolipid metabolism_Homo sapiens_hsa005610.31983417
116Tryptophan metabolism_Homo sapiens_hsa003800.31857765
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31504025
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.28423168
119Melanoma_Homo sapiens_hsa052180.27593249
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.25010415
121Pancreatic cancer_Homo sapiens_hsa052120.24779888
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.23556746
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.23300859
124HIF-1 signaling pathway_Homo sapiens_hsa040660.23136493
125Glioma_Homo sapiens_hsa052140.23102920
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23093420
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22913251
128AMPK signaling pathway_Homo sapiens_hsa041520.21534348
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21250025
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.20960398
131Hepatitis B_Homo sapiens_hsa051610.19767664
132Prion diseases_Homo sapiens_hsa050200.19374339
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19276420
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19006752
135Legionellosis_Homo sapiens_hsa051340.17945593
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.17001111
137Dorso-ventral axis formation_Homo sapiens_hsa043200.15200891
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.13515701
139Glucagon signaling pathway_Homo sapiens_hsa049220.13153242
140Selenocompound metabolism_Homo sapiens_hsa004500.12449009
141Rap1 signaling pathway_Homo sapiens_hsa040150.11980774
142Steroid biosynthesis_Homo sapiens_hsa001000.11748231
143Arginine and proline metabolism_Homo sapiens_hsa003300.06343623
144ErbB signaling pathway_Homo sapiens_hsa040120.06075251
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05557518
146Insulin signaling pathway_Homo sapiens_hsa049100.05232981
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.04845182
148FoxO signaling pathway_Homo sapiens_hsa040680.04784692

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