IGF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.74807424
2L-phenylalanine catabolic process (GO:0006559)6.74807424
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.29604878
4L-phenylalanine metabolic process (GO:0006558)6.29604878
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.29115921
6aromatic amino acid family catabolic process (GO:0009074)6.09723189
7indole-containing compound catabolic process (GO:0042436)5.56331830
8indolalkylamine catabolic process (GO:0046218)5.56331830
9tryptophan catabolic process (GO:0006569)5.56331830
10complement activation, alternative pathway (GO:0006957)5.47227175
11protein carboxylation (GO:0018214)5.41229026
12peptidyl-glutamic acid carboxylation (GO:0017187)5.41229026
13bile acid biosynthetic process (GO:0006699)5.34750664
14tryptophan metabolic process (GO:0006568)5.30710786
15kynurenine metabolic process (GO:0070189)5.30328719
16regulation of protein activation cascade (GO:2000257)5.21971297
17urea metabolic process (GO:0019627)5.12183168
18urea cycle (GO:0000050)5.12183168
19alpha-linolenic acid metabolic process (GO:0036109)5.03316519
20high-density lipoprotein particle remodeling (GO:0034375)4.97563170
21negative regulation of fibrinolysis (GO:0051918)4.95720677
22regulation of complement activation (GO:0030449)4.93745030
23regulation of fibrinolysis (GO:0051917)4.92490972
24glyoxylate metabolic process (GO:0046487)4.86987223
25bile acid metabolic process (GO:0008206)4.64975372
26nitrogen cycle metabolic process (GO:0071941)4.64251159
27sulfur amino acid catabolic process (GO:0000098)4.61660732
28reverse cholesterol transport (GO:0043691)4.52011060
29cysteine metabolic process (GO:0006534)4.46471641
30homocysteine metabolic process (GO:0050667)4.46243338
31protein-lipid complex remodeling (GO:0034368)4.43035887
32macromolecular complex remodeling (GO:0034367)4.43035887
33plasma lipoprotein particle remodeling (GO:0034369)4.43035887
34plasma lipoprotein particle clearance (GO:0034381)4.42020024
35tyrosine metabolic process (GO:0006570)4.40163663
36exogenous drug catabolic process (GO:0042738)4.39041463
37regulation of cholesterol esterification (GO:0010872)4.38265359
38regulation of triglyceride catabolic process (GO:0010896)4.37389054
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.37369012
40phospholipid efflux (GO:0033700)4.34376607
41aromatic amino acid family metabolic process (GO:0009072)4.32021715
42triglyceride homeostasis (GO:0070328)4.27200011
43acylglycerol homeostasis (GO:0055090)4.27200011
44cholesterol efflux (GO:0033344)4.20264201
45omega-hydroxylase P450 pathway (GO:0097267)4.18811031
46serine family amino acid catabolic process (GO:0009071)4.15802420
47alpha-amino acid catabolic process (GO:1901606)4.14165158
48coenzyme catabolic process (GO:0009109)4.13618628
49glutamate metabolic process (GO:0006536)4.10180299
50epoxygenase P450 pathway (GO:0019373)4.09537201
51cellular ketone body metabolic process (GO:0046950)4.05730652
52amino-acid betaine metabolic process (GO:0006577)4.00209829
53negative regulation of cholesterol transport (GO:0032375)3.98362642
54negative regulation of sterol transport (GO:0032372)3.98362642
55keratan sulfate catabolic process (GO:0042340)3.95854002
56indolalkylamine metabolic process (GO:0006586)3.92219182
57fibrinolysis (GO:0042730)3.91952000
58lysine metabolic process (GO:0006553)3.91563596
59lysine catabolic process (GO:0006554)3.91563596
60bile acid and bile salt transport (GO:0015721)3.90778161
61cellular glucuronidation (GO:0052695)3.88198835
62amine catabolic process (GO:0009310)3.84889585
63cellular biogenic amine catabolic process (GO:0042402)3.84889585
64cofactor catabolic process (GO:0051187)3.82319947
65ethanol oxidation (GO:0006069)3.81388801
66cellular amino acid catabolic process (GO:0009063)3.80622358
67regulation of sequestering of triglyceride (GO:0010889)3.80084218
68arginine metabolic process (GO:0006525)3.73695951
69complement activation (GO:0006956)3.70080719
70plasma lipoprotein particle assembly (GO:0034377)3.69899954
71phospholipid homeostasis (GO:0055091)3.69402391
72aldehyde catabolic process (GO:0046185)3.67662540
73positive regulation of lipid catabolic process (GO:0050996)3.65349930
74complement activation, classical pathway (GO:0006958)3.65021174
75peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.64790336
76benzene-containing compound metabolic process (GO:0042537)3.60891660
77low-density lipoprotein particle remodeling (GO:0034374)3.60467600
78imidazole-containing compound metabolic process (GO:0052803)3.59877597
79uronic acid metabolic process (GO:0006063)3.56829913
80glucuronate metabolic process (GO:0019585)3.56829913
81protein activation cascade (GO:0072376)3.55897438
82opsonization (GO:0008228)3.54829096
83cellular modified amino acid catabolic process (GO:0042219)3.51645778
84ovulation from ovarian follicle (GO:0001542)3.48468622
85ketone body metabolic process (GO:1902224)3.46925219
86positive regulation of fatty acid beta-oxidation (GO:0032000)3.44605649
87plasma lipoprotein particle organization (GO:0071827)3.43717276
88negative regulation of lipase activity (GO:0060192)3.43568015
89very-low-density lipoprotein particle assembly (GO:0034379)3.43282022
90dicarboxylic acid biosynthetic process (GO:0043650)3.39329200
91regulation of fatty acid beta-oxidation (GO:0031998)3.38942180
92lipoprotein metabolic process (GO:0042157)3.38586633
93glycine metabolic process (GO:0006544)3.38254459
94cholesterol homeostasis (GO:0042632)3.37955103
95drug catabolic process (GO:0042737)3.36668647
96blood coagulation, intrinsic pathway (GO:0007597)3.34830129
97protein-lipid complex assembly (GO:0065005)3.33600612
98sterol homeostasis (GO:0055092)3.33179102
99carboxylic acid catabolic process (GO:0046395)3.30430473
100organic acid catabolic process (GO:0016054)3.30430473
101negative regulation of protein activation cascade (GO:2000258)3.29215950
102NAD biosynthetic process (GO:0009435)3.28759790
103cytolysis (GO:0019835)3.27539636
104regulation of bile acid biosynthetic process (GO:0070857)3.26711225
105oxidative demethylation (GO:0070989)3.25381780
106protein-lipid complex subunit organization (GO:0071825)3.24329444
107serine family amino acid metabolic process (GO:0009069)3.23347806
108positive regulation of lipoprotein lipase activity (GO:0051006)3.22763069
109positive regulation of triglyceride lipase activity (GO:0061365)3.22763069
110negative regulation of complement activation (GO:0045916)3.15761272
111negative regulation of gluconeogenesis (GO:0045721)3.14103269
112regulation of phospholipase A2 activity (GO:0032429)3.05361799
113ethanol metabolic process (GO:0006067)2.99110755
114S-adenosylmethionine metabolic process (GO:0046500)2.97818757
115extracellular fibril organization (GO:0043206)2.94817375
116valine metabolic process (GO:0006573)2.93858107
117low-density lipoprotein particle clearance (GO:0034383)2.88531253
118drug metabolic process (GO:0017144)2.80139397
119transcytosis (GO:0045056)2.77175538
120parturition (GO:0007567)2.75148626
121behavioral response to nicotine (GO:0035095)2.68606877
122positive regulation of glomerulus development (GO:0090193)2.68375623
123triglyceride catabolic process (GO:0019433)2.63857943
124positive regulation of fatty acid oxidation (GO:0046321)2.62599117
125retinal metabolic process (GO:0042574)2.59373357
126positive regulation of metanephros development (GO:0072216)2.54222611
127negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.53920279
128fatty acid transmembrane transport (GO:1902001)2.53035129
129fibril organization (GO:0097435)2.50460969
130pyrimidine nucleobase catabolic process (GO:0006208)2.49874843
131flavonoid metabolic process (GO:0009812)2.47418532
132indole-containing compound metabolic process (GO:0042430)2.44395552
133acylglycerol catabolic process (GO:0046464)2.43956986
134neutral lipid catabolic process (GO:0046461)2.43956986
135negative regulation of systemic arterial blood pressure (GO:0003085)2.43006164
136amino acid salvage (GO:0043102)2.42275401
137L-methionine salvage (GO:0071267)2.42275401
138L-methionine biosynthetic process (GO:0071265)2.42275401
139positive regulation of lipid storage (GO:0010884)2.40317950
140protein homotrimerization (GO:0070207)2.37690134
141protein trimerization (GO:0070206)2.35793577
142adhesion of symbiont to host cell (GO:0044650)2.35283002
143virion attachment to host cell (GO:0019062)2.35283002
144interkinetic nuclear migration (GO:0022027)2.34931993
145acute-phase response (GO:0006953)2.33625279
146positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.33189736
147* primary alcohol metabolic process (GO:0034308)2.32827001
148regulation of macrophage derived foam cell differentiation (GO:0010743)2.31982258
149positive regulation of sterol transport (GO:0032373)2.30637909
150positive regulation of cholesterol transport (GO:0032376)2.30637909

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.53455642
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.78374809
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.68185656
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.63045066
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.45672425
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.52040466
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.20281800
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.72258603
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.57368043
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.81970957
11VDR_22108803_ChIP-Seq_LS180_Human2.41461158
12EZH2_22144423_ChIP-Seq_EOC_Human2.40710909
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06745476
14IGF1R_20145208_ChIP-Seq_DFB_Human2.04309410
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97142851
16* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93715760
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91175513
18TAF15_26573619_Chip-Seq_HEK293_Human1.89032674
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83821597
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77572091
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.71700359
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.69880995
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66939100
24AR_21572438_ChIP-Seq_LNCaP_Human1.63584005
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61997807
26CLOCK_20551151_ChIP-Seq_293T_Human1.60726254
27ZNF274_21170338_ChIP-Seq_K562_Hela1.53936664
28HTT_18923047_ChIP-ChIP_STHdh_Human1.52126844
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49016085
30* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48043474
31* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.45496872
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.45303191
33ER_23166858_ChIP-Seq_MCF-7_Human1.44009309
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.40740220
35* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40553654
36* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40553654
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39416054
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.36648074
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36435954
40STAT3_23295773_ChIP-Seq_U87_Human1.35217471
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34731894
42CBP_20019798_ChIP-Seq_JUKART_Human1.34731894
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34640394
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33811120
45* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32665093
46* EZH2_27294783_Chip-Seq_NPCs_Mouse1.32233644
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28916900
48* TCF4_23295773_ChIP-Seq_U87_Human1.27801899
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24806100
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.24538312
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24055689
52FUS_26573619_Chip-Seq_HEK293_Human1.22933475
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.22788207
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.22666010
55* SMAD3_21741376_ChIP-Seq_EPCs_Human1.21780995
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.20543039
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19933543
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19928348
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.18139410
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.18128927
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17942535
62* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16812909
63GBX2_23144817_ChIP-Seq_PC3_Human1.16559400
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.16464980
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.16407584
66* CDX2_22108803_ChIP-Seq_LS180_Human1.15349162
67GATA1_22025678_ChIP-Seq_K562_Human1.13060809
68SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12502330
69* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12362408
70DROSHA_22980978_ChIP-Seq_HELA_Human1.12320873
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11284201
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.09524386
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09482036
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07935477
75* HNF4A_19822575_ChIP-Seq_HepG2_Human1.06765192
76P53_22387025_ChIP-Seq_ESCs_Mouse1.05137891
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04684942
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04684942
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.04479099
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03309973
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.02582507
82RUNX2_22187159_ChIP-Seq_PCA_Human1.02300094
83* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01508723
84* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00861631
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.00854317
86KDM2B_26808549_Chip-Seq_REH_Human1.00661685
87NANOG_19829295_ChIP-Seq_ESCs_Human1.00360340
88SOX2_19829295_ChIP-Seq_ESCs_Human1.00360340
89RXR_22108803_ChIP-Seq_LS180_Human0.99610868
90E2F1_18555785_Chip-Seq_ESCs_Mouse0.99104244
91* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99047922
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98467757
93MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97388790
94SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96550565
95CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96135592
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95946750
97SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95166269
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91500922
99SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91109122
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90511688
101TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89399684
102RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87188858
103CJUN_26792858_Chip-Seq_BT549_Human0.85386517
104P300_19829295_ChIP-Seq_ESCs_Human0.84181533
105VDR_24787735_ChIP-Seq_THP-1_Human0.82926049
106BCAT_22108803_ChIP-Seq_LS180_Human0.82751360
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81867243
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80733226
109ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80347455
110SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80262254
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.80142757
112ZFP57_27257070_Chip-Seq_ESCs_Mouse0.78679726
113ARNT_22903824_ChIP-Seq_MCF-7_Human0.78485445
114* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.76254919
115TP53_18474530_ChIP-ChIP_U2OS_Human0.75461979
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75178783
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74994532
118RXRA_24833708_ChIP-Seq_LIVER_Mouse0.73557413
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73038252
120SOX2_20726797_ChIP-Seq_SW620_Human0.71588557
121* SMAD4_21799915_ChIP-Seq_A2780_Human0.69780365
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.67853335
123* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67489275
124ESR2_21235772_ChIP-Seq_MCF-7_Human0.67210239
125GATA2_21666600_ChIP-Seq_HMVEC_Human0.66832859
126SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.65876243
127EED_16625203_ChIP-ChIP_MESCs_Mouse0.64507100
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.64402753
129* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63862050
130EP300_21415370_ChIP-Seq_HL-1_Mouse0.63015945
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.63011240
132CTBP2_25329375_ChIP-Seq_LNCAP_Human0.62560678
133AHR_22903824_ChIP-Seq_MCF-7_Human0.62057150
134* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.61339627
135SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.60954216
136* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60428757
137* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.60338691
138* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.60255948
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.59620616
140TCF4_22108803_ChIP-Seq_LS180_Human0.59185324
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.58777765
142* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.58596674
143AR_25329375_ChIP-Seq_VCAP_Human0.58287984
144ESR1_15608294_ChIP-ChIP_MCF-7_Human0.57669775
145FOXM1_26456572_ChIP-Seq_MCF-7_Human0.57523417
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.57322707
147* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.56758981
148* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.55533485
149FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55209837
150GATA4_25053715_ChIP-Seq_YYC3_Human0.54696701
151* TP63_23658742_ChIP-Seq_EP156T_Human0.54473625
152NR3C1_23031785_ChIP-Seq_PC12_Mouse0.54426320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.43161403
2MP0005360_urolithiasis6.61667765
3MP0005085_abnormal_gallbladder_physiolo5.70225773
4MP0005365_abnormal_bile_salt5.56470388
5MP0008875_abnormal_xenobiotic_pharmacok4.71714775
6MP0003252_abnormal_bile_duct3.70987573
7MP0010329_abnormal_lipoprotein_level3.50139909
8MP0009840_abnormal_foam_cell3.45907618
9MP0005083_abnormal_biliary_tract2.96457599
10MP0003806_abnormal_nucleotide_metabolis2.88597499
11MP0003195_calcinosis2.86146580
12MP0008438_abnormal_cutaneous_collagen2.64211904
13MP0003646_muscle_fatigue2.53732143
14MP0010386_abnormal_urinary_bladder2.53578513
15MP0005332_abnormal_amino_acid2.43896672
16MP0003191_abnormal_cellular_cholesterol2.31358623
17MP0001666_abnormal_nutrient_absorption2.18381987
18MP0004019_abnormal_vitamin_homeostasis2.02063409
19MP0009697_abnormal_copulation2.01791229
20MP0000609_abnormal_liver_physiology1.94648781
21MP0002118_abnormal_lipid_homeostasis1.92454296
22MP0003705_abnormal_hypodermis_morpholog1.86302800
23MP0001501_abnormal_sleep_pattern1.83335390
24* MP0002108_abnormal_muscle_morphology1.80900320
25MP0005167_abnormal_blood-brain_barrier1.80292635
26MP0002638_abnormal_pupillary_reflex1.68922977
27MP0002138_abnormal_hepatobiliary_system1.68770415
28MP0005319_abnormal_enzyme/_coenzyme1.68228598
29MP0004145_abnormal_muscle_electrophysio1.58353223
30MP0004043_abnormal_pH_regulation1.57904493
31MP0010368_abnormal_lymphatic_system1.57712749
32MP0002822_catalepsy1.57275425
33MP0003868_abnormal_feces_composition1.49653250
34MP0005275_abnormal_skin_tensile1.49552379
35MP0005584_abnormal_enzyme/coenzyme_acti1.47382537
36MP0002933_joint_inflammation1.45722736
37MP0005666_abnormal_adipose_tissue1.36355065
38MP0005647_abnormal_sex_gland1.36248371
39MP0001764_abnormal_homeostasis1.34436982
40MP0004215_abnormal_myocardial_fiber1.33948774
41MP0009764_decreased_sensitivity_to1.32175709
42MP0005670_abnormal_white_adipose1.31164984
43MP0000604_amyloidosis1.30916457
44MP0002876_abnormal_thyroid_physiology1.30852717
45MP0000751_myopathy1.27901601
46MP0005503_abnormal_tendon_morphology1.25777936
47MP0004130_abnormal_muscle_cell1.16421198
48MP0003690_abnormal_glial_cell1.15258894
49MP0005375_adipose_tissue_phenotype1.14144529
50MP0009763_increased_sensitivity_to1.13246647
51MP0003011_delayed_dark_adaptation1.10918750
52MP0000598_abnormal_liver_morphology1.08619391
53MP0005058_abnormal_lysosome_morphology1.07612868
54MP0002254_reproductive_system_inflammat1.06779827
55MP0000343_altered_response_to1.06486159
56MP0008469_abnormal_protein_level1.05381406
57MP0000372_irregular_coat_pigmentation1.05289808
58MP0009643_abnormal_urine_homeostasis1.02718072
59MP0003186_abnormal_redox_activity0.99913016
60MP0005451_abnormal_body_composition0.99381899
61MP0004134_abnormal_chest_morphology0.98079246
62* MP0000230_abnormal_systemic_arterial0.93732169
63MP0003656_abnormal_erythrocyte_physiolo0.93473423
64MP0004782_abnormal_surfactant_physiolog0.93380241
65MP0003436_decreased_susceptibility_to0.92661225
66MP0003959_abnormal_lean_body0.92142662
67MP0002837_dystrophic_cardiac_calcinosis0.92051429
68MP0003724_increased_susceptibility_to0.91974477
69MP0005620_abnormal_muscle_contractility0.90087552
70MP0006082_CNS_inflammation0.88748811
71MP0005508_abnormal_skeleton_morphology0.87618794
72MP0005334_abnormal_fat_pad0.87312294
73MP0004036_abnormal_muscle_relaxation0.84219458
74MP0002332_abnormal_exercise_endurance0.84113833
75MP0008004_abnormal_stomach_pH0.83683718
76MP0005084_abnormal_gallbladder_morpholo0.83202042
77MP0000639_abnormal_adrenal_gland0.82034346
78* MP0005369_muscle_phenotype0.81300068
79MP0005171_absent_coat_pigmentation0.80011037
80MP0002060_abnormal_skin_morphology0.79520534
81MP0009642_abnormal_blood_homeostasis0.79384425
82MP0005551_abnormal_eye_electrophysiolog0.79254985
83MP0003045_fibrosis0.78599046
84MP0003879_abnormal_hair_cell0.77520573
85MP0003137_abnormal_impulse_conducting0.76687757
86MP0005448_abnormal_energy_balance0.76257368
87MP0009765_abnormal_xenobiotic_induced0.75980040
88* MP0002970_abnormal_white_adipose0.75786230
89MP0000538_abnormal_urinary_bladder0.75525369
90MP0006054_spinal_hemorrhage0.74583441
91MP0000767_abnormal_smooth_muscle0.74247443
92* MP0002078_abnormal_glucose_homeostasis0.73272048
93MP0005646_abnormal_pituitary_gland0.72741192
94MP0001440_abnormal_grooming_behavior0.72450134
95MP0005220_abnormal_exocrine_pancreas0.72088308
96MP0005390_skeleton_phenotype0.71394742
97MP0003123_paternal_imprinting0.71293709
98MP0009046_muscle_twitch0.70627452
99MP0005376_homeostasis/metabolism_phenot0.70563358
100MP0004084_abnormal_cardiac_muscle0.70450497
101MP0002971_abnormal_brown_adipose0.70398153
102MP0009780_abnormal_chondrocyte_physiolo0.70001104
103MP0001270_distended_abdomen0.69283752
104MP0001661_extended_life_span0.68389269
105MP0004883_abnormal_blood_vessel0.67064637
106MP0002735_abnormal_chemical_nociception0.66150082
107MP0009745_abnormal_behavioral_response0.65791748
108MP0004142_abnormal_muscle_tone0.64906500
109* MP0000163_abnormal_cartilage_morphology0.64352374
110MP0006276_abnormal_autonomic_nervous0.64001352
111MP0004484_altered_response_of0.63869102
112MP0002419_abnormal_innate_immunity0.63702766
113MP0005248_abnormal_Harderian_gland0.63337571
114MP0001958_emphysema0.62895824
115MP0008872_abnormal_physiological_respon0.62061101
116MP0000003_abnormal_adipose_tissue0.61724773
117MP0009115_abnormal_fat_cell0.61007904
118MP0001243_abnormal_dermal_layer0.60644647
119MP0001533_abnormal_skeleton_physiology0.60362345
120MP0002106_abnormal_muscle_physiology0.60206825
121MP0005164_abnormal_response_to0.59875803
122MP0000749_muscle_degeneration0.59747496
123MP0002272_abnormal_nervous_system0.59319478
124MP0005408_hypopigmentation0.58140466
125* MP0003638_abnormal_response/metabolism_0.58031834
126MP0009053_abnormal_anal_canal0.57745886
127MP0002090_abnormal_vision0.57733738
128MP0003075_altered_response_to0.56911614
129MP0005636_abnormal_mineral_homeostasis0.56785994
130MP0009384_cardiac_valve_regurgitation0.55988917
131MP0005535_abnormal_body_temperature0.55073954
132MP0003385_abnormal_body_wall0.53992216
133MP0003279_aneurysm0.53114703
134MP0005595_abnormal_vascular_smooth0.51086935
135MP0005166_decreased_susceptibility_to0.50020765
136MP0005464_abnormal_platelet_physiology0.48835864
137MP0001756_abnormal_urination0.47989414
138MP0000249_abnormal_blood_vessel0.46652040
139MP0005395_other_phenotype0.44386939
140MP0005023_abnormal_wound_healing0.43751815
141MP0005257_abnormal_intraocular_pressure0.42820741
142MP0001879_abnormal_lymphatic_vessel0.42481632
143MP0002136_abnormal_kidney_physiology0.42245981
144MP0001845_abnormal_inflammatory_respons0.41512281
145MP0002168_other_aberrant_phenotype0.41155673
146MP0002282_abnormal_trachea_morphology0.40591169
147MP0002295_abnormal_pulmonary_circulatio0.39678138
148MP0005266_abnormal_metabolism0.39263214
149MP0003787_abnormal_imprinting0.38812647

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.73953117
2Intrahepatic cholestasis (HP:0001406)6.15197822
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.09479325
4Complement deficiency (HP:0004431)6.07768981
5Xanthomatosis (HP:0000991)5.93574119
6Prolonged partial thromboplastin time (HP:0003645)5.85153594
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.80244336
8Hyperlipoproteinemia (HP:0010980)5.42416452
9Hypobetalipoproteinemia (HP:0003563)5.41289999
10Joint hemorrhage (HP:0005261)4.90088887
11Epidermoid cyst (HP:0200040)4.56075439
12Abnormality of complement system (HP:0005339)4.55141715
13Hypolipoproteinemia (HP:0010981)4.38668385
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.19313444
15Systemic lupus erythematosus (HP:0002725)4.18724608
16Hypoalphalipoproteinemia (HP:0003233)4.18579329
17Abnormality of the common coagulation pathway (HP:0010990)4.14742245
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.96512356
19Myocardial infarction (HP:0001658)3.77848190
20Hypercholesterolemia (HP:0003124)3.76006055
21Wrist flexion contracture (HP:0001239)3.75660170
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.70215240
23Hyperammonemia (HP:0001987)3.69511472
24Fat malabsorption (HP:0002630)3.67570438
25Abnormality of methionine metabolism (HP:0010901)3.58327897
26Ketosis (HP:0001946)3.47861929
27Hyperglycinemia (HP:0002154)3.46969089
28Recurrent gram-negative bacterial infections (HP:0005420)3.45850425
29Abnormality of the intrinsic pathway (HP:0010989)3.45545563
30Glomerulonephritis (HP:0000099)3.42215698
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.41107022
32Arthropathy (HP:0003040)3.35600021
33Conjugated hyperbilirubinemia (HP:0002908)3.34385692
34Abnormality of pyrimidine metabolism (HP:0004353)3.28291857
35Aortic aneurysm (HP:0004942)3.27502166
36Aortic dissection (HP:0002647)3.24744417
37Skin nodule (HP:0200036)3.14295506
38Hepatoblastoma (HP:0002884)3.13477889
39Mitral stenosis (HP:0001718)3.12276648
40Spontaneous abortion (HP:0005268)3.07759553
41Enlarged kidneys (HP:0000105)3.07386604
42Hyperglycinuria (HP:0003108)3.06203945
43Spastic diplegia (HP:0001264)3.00712988
44Abnormality of serine family amino acid metabolism (HP:0010894)3.00085613
45Abnormality of glycine metabolism (HP:0010895)3.00085613
46Increased corneal curvature (HP:0100692)2.98864952
47Keratoconus (HP:0000563)2.98864952
48Abnormality of fatty-acid metabolism (HP:0004359)2.98038206
49Hypoglycemic coma (HP:0001325)2.86583187
50Steatorrhea (HP:0002570)2.85040733
51Hepatocellular carcinoma (HP:0001402)2.79614024
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.75712075
53Abnormality of nucleobase metabolism (HP:0010932)2.72079258
54Striae distensae (HP:0001065)2.72009660
55Thyroid-stimulating hormone excess (HP:0002925)2.65800093
56Hyperbilirubinemia (HP:0002904)2.62285511
57Round ear (HP:0100830)2.56879439
58Mutism (HP:0002300)2.49088716
59Bone cyst (HP:0012062)2.45474545
60Abnormality of serum amino acid levels (HP:0003112)2.43981490
61Abnormality of purine metabolism (HP:0004352)2.43972959
62Pancreatic cysts (HP:0001737)2.43036264
63Soft skin (HP:0000977)2.39951651
64Ketoacidosis (HP:0001993)2.39443967
65Cardiovascular calcification (HP:0011915)2.36381267
66Amyloidosis (HP:0011034)2.34788132
67Nephritis (HP:0000123)2.33247217
68Vascular calcification (HP:0004934)2.32550464
69Gingival bleeding (HP:0000225)2.32443754
70Pancreatic fibrosis (HP:0100732)2.31163548
71Neonatal hypoglycemia (HP:0001998)2.27062307
72Corneal dystrophy (HP:0001131)2.26619025
73Hydroxyprolinuria (HP:0003080)2.26198938
74Abnormality of proline metabolism (HP:0010907)2.26198938
75Oligomenorrhea (HP:0000876)2.26110241
76Inability to walk (HP:0002540)2.25314526
77Distal arthrogryposis (HP:0005684)2.24167081
78Diastasis recti (HP:0001540)2.23950389
79Abnormal gallbladder morphology (HP:0012437)2.22542291
80Hypochromic microcytic anemia (HP:0004840)2.22372687
81Abnormality of the renal cortex (HP:0011035)2.22088661
82Upper motor neuron abnormality (HP:0002127)2.21666868
83Delayed CNS myelination (HP:0002188)2.21407072
84Esophageal varix (HP:0002040)2.20922072
85Cholelithiasis (HP:0001081)2.20857711
86Metabolic acidosis (HP:0001942)2.18075802
87Decreased circulating renin level (HP:0003351)2.16240291
88Pulmonary artery stenosis (HP:0004415)2.16107297
89Abnormality of alanine metabolism (HP:0010916)2.14882367
90Hyperalaninemia (HP:0003348)2.14882367
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14882367
92Broad metatarsal (HP:0001783)2.10535438
93Hyperventilation (HP:0002883)2.09078985
94True hermaphroditism (HP:0010459)2.08071086
95Abnormal gallbladder physiology (HP:0012438)2.08018995
96Cholecystitis (HP:0001082)2.08018995
97Thrombophlebitis (HP:0004418)2.07957363
98Cerebral edema (HP:0002181)2.05766840
99Hypothermia (HP:0002045)2.04332736
100Hypophosphatemic rickets (HP:0004912)2.03666108
101Lethargy (HP:0001254)2.02076362
102Menorrhagia (HP:0000132)2.01410318
103Generalized hypopigmentation of hair (HP:0011358)2.00939372
104Acanthocytosis (HP:0001927)1.97906596
105Thyroiditis (HP:0100646)1.97817127
106Spontaneous hematomas (HP:0007420)1.96898284
107Tubulointerstitial fibrosis (HP:0005576)1.95435076
108Hypoglycemic seizures (HP:0002173)1.94810537
109Broad-based gait (HP:0002136)1.94359394
110Pancreatitis (HP:0001733)1.93208548
111Nausea (HP:0002018)1.93201089
112Hemorrhage of the eye (HP:0011885)1.92101335
113Axonal loss (HP:0003447)1.91706014
114Abnormality of liposaccharide metabolism (HP:0010968)1.91470754
115Abnormality of glycosphingolipid metabolism (HP:0004343)1.91470754
116Abnormality of glycolipid metabolism (HP:0010969)1.91470754
117Hematochezia (HP:0002573)1.91311216
118Absent speech (HP:0001344)1.90763407
119Prolonged QT interval (HP:0001657)1.90749567
120Potter facies (HP:0002009)1.90073743
121Facial shape deformation (HP:0011334)1.90073743
122Cerebral aneurysm (HP:0004944)1.89315826
123Progressive inability to walk (HP:0002505)1.88779705
124Hip contracture (HP:0003273)1.88616451
125Sensorimotor neuropathy (HP:0007141)1.88148094
126Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86168901
127Dicarboxylic aciduria (HP:0003215)1.86168901
128Abnormal finger flexion creases (HP:0006143)1.84418162
129Calf muscle hypertrophy (HP:0008981)1.84119619
130Fair hair (HP:0002286)1.83649665
131Action tremor (HP:0002345)1.82797665
132Nephronophthisis (HP:0000090)1.82571912
133Abnormality of the gallbladder (HP:0005264)1.81077801
134Vacuolated lymphocytes (HP:0001922)1.80760582
135Hypoplastic ischia (HP:0003175)1.80375580
136Limited hip movement (HP:0008800)1.80294573
137Hypokalemia (HP:0002900)1.77830602
138Opisthotonus (HP:0002179)1.77394309
139Gaze-evoked nystagmus (HP:0000640)1.77355520
140Vomiting (HP:0002013)1.77270244
141Abnormality of the renal medulla (HP:0100957)1.77078110
142Mesangial abnormality (HP:0001966)1.76498397
143Abnormality of iron homeostasis (HP:0011031)1.75630046
144Irritability (HP:0000737)1.75493998
145Gout (HP:0001997)1.75364409
146Pulmonary embolism (HP:0002204)1.74698983
147Esophageal neoplasm (HP:0100751)1.74630364
148Neoplasm of head and neck (HP:0012288)1.74630364
149Infantile muscular hypotonia (HP:0008947)1.74435541
150Congenital sensorineural hearing impairment (HP:0008527)1.73935125
151Insulin-resistant diabetes mellitus (HP:0000831)1.73724651
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.73565171
153Conjunctival telangiectasia (HP:0000524)1.73212391
154Neonatal onset (HP:0003623)1.72786945
155Muscle fiber splitting (HP:0003555)1.72718617
156Epiphyseal stippling (HP:0010655)1.72073942
157Abolished electroretinogram (ERG) (HP:0000550)1.70825933
158Joint stiffness (HP:0001387)1.70757702
159Absent phalangeal crease (HP:0006109)1.67976061
160Tubulointerstitial abnormality (HP:0001969)1.67938834
161Generalized aminoaciduria (HP:0002909)1.67668900
162Status epilepticus (HP:0002133)1.67660636
163Muscle hypertrophy of the lower extremities (HP:0008968)1.67624525
164Type 1 muscle fiber predominance (HP:0003803)1.67006560
165Pigmentary retinal degeneration (HP:0001146)1.66859418
166Polyphagia (HP:0002591)1.65906353
167Retinal atrophy (HP:0001105)1.65512451
168Tubular atrophy (HP:0000092)1.65342234
169Progressive cerebellar ataxia (HP:0002073)1.65032298
170Abnormality of the ischium (HP:0003174)1.64907071
171Bulbous nose (HP:0000414)1.64727632
172Abnormal EKG (HP:0003115)1.64603999
173Abnormality of glycosaminoglycan metabolism (HP:0004371)1.61959806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.18082176
2SIK14.06752868
3ERN13.55098152
4ERBB43.51023066
5FGFR42.73527425
6INSRR2.57499546
7ACVR1B2.56968726
8TAOK32.44951114
9FRK2.37040751
10AKT32.35907174
11CASK2.25884390
12OBSCN2.19311955
13ADRBK22.12211761
14EPHA31.97795558
15NLK1.86459308
16MAP3K141.84173018
17IRAK31.81374980
18CAMKK21.70868817
19NUAK11.69727558
20MAP2K41.69360806
21GRK11.67480719
22TYK21.64450267
23MST1R1.60204547
24LATS11.57284994
25TGFBR21.54744503
26KIT1.54322114
27MARK11.52970256
28CAMK1D1.49257696
29TBK11.45596088
30JAK11.42520064
31WNK31.42292538
32PKN21.41308227
33PIK3CG1.37854692
34PTK61.35014910
35MAP4K21.28842570
36MAPK131.28413413
37NEK91.19266163
38JAK21.13245950
39SGK21.12807932
40PDK31.12263362
41PDK41.12263362
42STK38L1.12237316
43PDK21.11331123
44FLT31.09212472
45DAPK21.07577911
46TRPM71.04848929
47CAMK11.03376091
48ABL21.02957329
49ADRBK11.02165177
50PKN11.01699895
51CDC42BPA1.01250830
52IRAK40.99845475
53SGK30.99567611
54FGFR20.98916188
55PBK0.97607015
56PHKG20.96473174
57PHKG10.96473174
58STK30.95902584
59CCNB10.95735522
60FGFR30.92919019
61MYLK0.92641585
62CSF1R0.92343326
63GRK70.92157429
64CSNK1G10.91568140
65MAPK110.91357971
66IRAK10.89635328
67NTRK30.89472343
68PRKCZ0.88279441
69TNIK0.87451159
70CAMK1G0.87264954
71PDGFRB0.86582889
72PRKG10.85167912
73IRAK20.84742867
74GRK50.84495788
75TIE10.83363213
76MAP3K70.81476755
77PRKCG0.79370295
78PRKAA20.78780281
79TRIB30.78547475
80MAPKAPK30.76492007
81MAP3K40.75589175
82PRKCE0.74919999
83SIK30.74744128
84MAP2K30.74541772
85GSK3A0.73607627
86OXSR10.72314837
87MAP3K30.70330076
88DDR20.69597740
89PLK20.69278622
90CSNK1G20.68965229
91PAK30.68419533
92IGF1R0.67130116
93CHUK0.67028639
94DMPK0.66638531
95ERBB20.66487823
96DYRK30.66445628
97PDGFRA0.65856788
98EPHA40.64044146
99CSK0.63447484
100PRKACA0.63443781
101PRKCH0.60597150
102IKBKE0.60430211
103PINK10.60097674
104PIM10.59427411
105PRKACG0.59256057
106PRKAA10.59040250
107CDK60.58856292
108ERBB30.56865074
109BMPR1B0.56478594
110SGK4940.53906174
111SGK2230.53906174
112CAMK40.53706995
113CSNK1A10.53699430
114CAMK2A0.53032525
115CDK80.52488266
116EGFR0.51951847
117ABL10.51129407
118MKNK20.50828973
119MAPK120.50197229
120MAP2K60.49710415
121MAPK70.49474346
122KDR0.48694323
123DYRK20.48305642
124PRKACB0.47756038
125MAP2K10.47649887
126TXK0.46938597
127EPHB20.46641603
128CAMK2G0.46166153
129PRKCD0.45152442
130PRKD10.44952244
131LATS20.44681533
132MAPKAPK50.44494656
133MAPK40.44130898
134MATK0.42219719
135SGK10.42153655
136CSNK1G30.41887440
137EIF2AK20.41743733
138PIK3CA0.41434438
139MARK20.41337819
140RIPK10.41168016
141TNK20.39557679
142BMPR20.39257504
143IKBKB0.38907444
144LYN0.35861407
145TGFBR10.35630667
146MAP3K20.35429479
147FER0.34908598
148BLK0.34651512
149MAP2K70.32321295
150INSR0.30693501

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.48820746
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35153733
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.20932103
4Nitrogen metabolism_Homo sapiens_hsa009103.15471239
5Complement and coagulation cascades_Homo sapiens_hsa046103.15414062
6Arginine biosynthesis_Homo sapiens_hsa002202.94823602
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.74645522
8Staphylococcus aureus infection_Homo sapiens_hsa051502.53803386
9Tryptophan metabolism_Homo sapiens_hsa003802.51582489
10Butanoate metabolism_Homo sapiens_hsa006502.40037619
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33681849
12Fatty acid degradation_Homo sapiens_hsa000712.33278546
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26987500
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24769575
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.15594139
16PPAR signaling pathway_Homo sapiens_hsa033202.02803885
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.02070094
18Peroxisome_Homo sapiens_hsa041461.97892316
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96711840
20beta-Alanine metabolism_Homo sapiens_hsa004101.92305718
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.91209322
22Caffeine metabolism_Homo sapiens_hsa002321.89133117
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.87943160
24Chemical carcinogenesis_Homo sapiens_hsa052041.85944080
25Propanoate metabolism_Homo sapiens_hsa006401.84125882
26Histidine metabolism_Homo sapiens_hsa003401.80774549
27Fatty acid metabolism_Homo sapiens_hsa012121.78055481
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.75898982
29Retinol metabolism_Homo sapiens_hsa008301.75073536
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57136368
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.56845023
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46859938
33Phenylalanine metabolism_Homo sapiens_hsa003601.46501568
34Arachidonic acid metabolism_Homo sapiens_hsa005901.38550304
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37602499
36Bile secretion_Homo sapiens_hsa049761.35288290
37Tyrosine metabolism_Homo sapiens_hsa003501.28377913
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23155502
39Starch and sucrose metabolism_Homo sapiens_hsa005001.22914720
40Fatty acid elongation_Homo sapiens_hsa000621.21971624
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21763511
42Pyruvate metabolism_Homo sapiens_hsa006201.21237889
43Steroid biosynthesis_Homo sapiens_hsa001001.17865790
44Selenocompound metabolism_Homo sapiens_hsa004501.15161592
45Fat digestion and absorption_Homo sapiens_hsa049751.11552405
46ABC transporters_Homo sapiens_hsa020101.08277286
47Sulfur metabolism_Homo sapiens_hsa009201.06774903
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.01897010
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98540957
50Carbon metabolism_Homo sapiens_hsa012000.97614192
51Biosynthesis of amino acids_Homo sapiens_hsa012300.97269128
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94327826
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93449865
54Folate biosynthesis_Homo sapiens_hsa007900.91131391
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.91055950
56Nicotine addiction_Homo sapiens_hsa050330.85790220
57Vitamin digestion and absorption_Homo sapiens_hsa049770.82294136
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81089445
59Arginine and proline metabolism_Homo sapiens_hsa003300.78918500
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75735311
61Glycerolipid metabolism_Homo sapiens_hsa005610.75385784
62Circadian rhythm_Homo sapiens_hsa047100.75209217
63Renin secretion_Homo sapiens_hsa049240.73522977
64Ether lipid metabolism_Homo sapiens_hsa005650.73374583
65Mineral absorption_Homo sapiens_hsa049780.72152277
66Serotonergic synapse_Homo sapiens_hsa047260.66828625
67Lysine degradation_Homo sapiens_hsa003100.65752046
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.65192091
69Vitamin B6 metabolism_Homo sapiens_hsa007500.58413171
70Morphine addiction_Homo sapiens_hsa050320.55375873
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.54844268
72Circadian entrainment_Homo sapiens_hsa047130.53963639
73Prion diseases_Homo sapiens_hsa050200.53868795
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53298241
75ECM-receptor interaction_Homo sapiens_hsa045120.52926754
76Pentose phosphate pathway_Homo sapiens_hsa000300.52873548
77GABAergic synapse_Homo sapiens_hsa047270.52679614
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52052706
79One carbon pool by folate_Homo sapiens_hsa006700.51193448
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50958885
81Fatty acid biosynthesis_Homo sapiens_hsa000610.49843196
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.46816020
83Taste transduction_Homo sapiens_hsa047420.46304804
84* Ovarian steroidogenesis_Homo sapiens_hsa049130.45805891
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44490557
86Glutamatergic synapse_Homo sapiens_hsa047240.44487618
87Glutathione metabolism_Homo sapiens_hsa004800.43361626
88Type II diabetes mellitus_Homo sapiens_hsa049300.41035531
89Phototransduction_Homo sapiens_hsa047440.40471719
90Cocaine addiction_Homo sapiens_hsa050300.38964097
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38854558
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38642515
93Metabolic pathways_Homo sapiens_hsa011000.35768419
94Sulfur relay system_Homo sapiens_hsa041220.33501943
95Lysosome_Homo sapiens_hsa041420.33202259
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.32549011
97* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31740611
98Calcium signaling pathway_Homo sapiens_hsa040200.31679080
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30920556
100Insulin resistance_Homo sapiens_hsa049310.29612934
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.28738341
102Asthma_Homo sapiens_hsa053100.28105140
103Oxidative phosphorylation_Homo sapiens_hsa001900.27830153
104Phagosome_Homo sapiens_hsa041450.26659662
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22654514
106Galactose metabolism_Homo sapiens_hsa000520.21477188
107Malaria_Homo sapiens_hsa051440.15987949
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12477704
109Rheumatoid arthritis_Homo sapiens_hsa053230.11723284
110Collecting duct acid secretion_Homo sapiens_hsa049660.11189087
111Fructose and mannose metabolism_Homo sapiens_hsa000510.10547775
112Pertussis_Homo sapiens_hsa051330.08519078
113Glucagon signaling pathway_Homo sapiens_hsa049220.06509877
114Amoebiasis_Homo sapiens_hsa051460.05787981
115Protein digestion and absorption_Homo sapiens_hsa049740.03302022
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.02841541
117African trypanosomiasis_Homo sapiens_hsa051430.02422944
118Renin-angiotensin system_Homo sapiens_hsa046140.02342181
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.02043130
120Legionellosis_Homo sapiens_hsa051340.01111783
121Tuberculosis_Homo sapiens_hsa051520.01080383
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.00117696
123Insulin signaling pathway_Homo sapiens_hsa04910-0.0900856
124Leishmaniasis_Homo sapiens_hsa05140-0.0870733
125* AMPK signaling pathway_Homo sapiens_hsa04152-0.0645498
126Type I diabetes mellitus_Homo sapiens_hsa04940-0.0636925
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0616825
128Hepatitis C_Homo sapiens_hsa05160-0.0546750
129Other glycan degradation_Homo sapiens_hsa00511-0.0407397
130Linoleic acid metabolism_Homo sapiens_hsa00591-0.0243458

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