IGF1R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.28151159
2bundle of His cell to Purkinje myocyte communication (GO:0086069)6.15453096
3negative regulation of keratinocyte proliferation (GO:0010839)5.96257008
4cell-substrate junction assembly (GO:0007044)5.44861931
5regulation of keratinocyte proliferation (GO:0010837)4.42475586
6lymph vessel development (GO:0001945)4.31501198
7dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.27503324
8gap junction assembly (GO:0016264)3.93142208
9regulation of transforming growth factor beta2 production (GO:0032909)3.76779083
10polarized epithelial cell differentiation (GO:0030859)3.76051217
11cell adhesion mediated by integrin (GO:0033627)3.69984554
12keratinocyte proliferation (GO:0043616)3.63605708
13apical protein localization (GO:0045176)3.59395128
14mating behavior (GO:0007617)3.53777625
15vascular endothelial growth factor signaling pathway (GO:0038084)3.44607785
16intestinal epithelial cell development (GO:0060576)3.37187370
17cardiac right ventricle morphogenesis (GO:0003215)3.36154047
18regulation of water loss via skin (GO:0033561)3.33966174
19definitive hemopoiesis (GO:0060216)3.29907058
20* positive regulation of hormone biosynthetic process (GO:0046886)3.19975068
21establishment of skin barrier (GO:0061436)3.18007318
22radial glial cell differentiation (GO:0060019)3.16136685
23endothelium development (GO:0003158)3.14787615
24hippo signaling (GO:0035329)3.13530985
25regulation of hair follicle development (GO:0051797)3.13112890
26endodermal cell differentiation (GO:0035987)3.11110431
27ER overload response (GO:0006983)3.09827667
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.07473189
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.07473189
30regulation of translation, ncRNA-mediated (GO:0045974)3.07473189
31kidney mesenchyme development (GO:0072074)3.06042995
32establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.05745954
33neural crest cell development (GO:0014032)3.05673461
34lymphangiogenesis (GO:0001946)2.93930449
35lateral sprouting from an epithelium (GO:0060601)2.91962028
36artery development (GO:0060840)2.90150977
37limb bud formation (GO:0060174)2.88797899
38chemical homeostasis within a tissue (GO:0048875)2.88305415
39ventricular trabecula myocardium morphogenesis (GO:0003222)2.88029870
40mesenchymal cell development (GO:0014031)2.86984419
41metanephric mesenchyme development (GO:0072075)2.86495591
42sequestering of extracellular ligand from receptor (GO:0035581)2.85330022
43embryonic camera-type eye morphogenesis (GO:0048596)2.83010875
44intermediate filament organization (GO:0045109)2.80268314
45protein localization to microtubule (GO:0035372)2.79528176
46surfactant homeostasis (GO:0043129)2.79252026
47regulation of heart morphogenesis (GO:2000826)2.78845825
48* epidermis development (GO:0008544)2.78373643
49germ cell migration (GO:0008354)2.76397465
50ectoderm development (GO:0007398)2.75757388
51regulation of axon extension involved in axon guidance (GO:0048841)2.75215133
52cell junction assembly (GO:0034329)2.74702697
53chondrocyte proliferation (GO:0035988)2.73894229
54asymmetric protein localization (GO:0008105)2.73768544
55atrial septum morphogenesis (GO:0060413)2.71946101
56skin development (GO:0043588)2.70835666
57semaphorin-plexin signaling pathway (GO:0071526)2.70324397
58negative chemotaxis (GO:0050919)2.69783401
59neuron projection extension involved in neuron projection guidance (GO:1902284)2.68167169
60axon extension involved in axon guidance (GO:0048846)2.68167169
61chondrocyte development (GO:0002063)2.68097822
62establishment of tissue polarity (GO:0007164)2.66923334
63establishment of planar polarity (GO:0001736)2.66923334
64regulation of secondary heart field cardioblast proliferation (GO:0003266)2.66524003
65regulation of cardioblast proliferation (GO:0003264)2.66524003
66plasma membrane repair (GO:0001778)2.64960432
67heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.64424194
68cell junction organization (GO:0034330)2.63592429
69mesenchyme morphogenesis (GO:0072132)2.62836473
70* mammary gland development (GO:0030879)2.62797315
71regulation of hippo signaling (GO:0035330)2.62657838
72heparan sulfate proteoglycan metabolic process (GO:0030201)2.61584363
73cellular copper ion homeostasis (GO:0006878)2.61030505
74negative regulation of stem cell proliferation (GO:2000647)2.60971724
75Notch signaling involved in heart development (GO:0061314)2.60737823
76* positive regulation of hormone metabolic process (GO:0032352)2.60498624
77bone trabecula formation (GO:0060346)2.59107754
78adherens junction organization (GO:0034332)2.58066347
79cytoskeletal anchoring at plasma membrane (GO:0007016)2.57279773
80cell surface receptor signaling pathway involved in heart development (GO:0061311)2.56756021
81regulation of mesenchymal cell proliferation (GO:0010464)2.56297111
82stem cell development (GO:0048864)2.55970988
83somite development (GO:0061053)2.55383070
84negative regulation of epidermis development (GO:0045683)2.53979787
85endocardial cushion morphogenesis (GO:0003203)2.53730378
86negative regulation of axon guidance (GO:1902668)2.53339253
87negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.50839277
88columnar/cuboidal epithelial cell development (GO:0002066)2.50502292
89vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.49466318
90establishment of apical/basal cell polarity (GO:0035089)2.49416522
91mesenchymal-epithelial cell signaling (GO:0060638)2.47867554
92heart morphogenesis (GO:0003007)2.47827892
93ganglion development (GO:0061548)2.47748746
94regulation of axon guidance (GO:1902667)2.47492394
95epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.47232029
96cell proliferation involved in kidney development (GO:0072111)2.47156151
97branching involved in salivary gland morphogenesis (GO:0060445)2.46230315
98histone H3-K4 trimethylation (GO:0080182)2.46101228
99notochord development (GO:0030903)2.45340150
100cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.44196194
101mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.43578408
102glomerulus development (GO:0032835)2.43354313
103positive regulation of mesenchymal cell proliferation (GO:0002053)2.42922097
104planar cell polarity pathway involved in neural tube closure (GO:0090179)2.42282785
105non-canonical Wnt signaling pathway (GO:0035567)2.42026881
106renal system development (GO:0072001)2.41541754
107epithelial cell fate commitment (GO:0072148)2.41331541
108epithelial cell differentiation involved in prostate gland development (GO:0060742)2.41139192
109ventricular cardiac muscle cell action potential (GO:0086005)2.40907101
110glomerular visceral epithelial cell development (GO:0072015)2.40789025
111type B pancreatic cell development (GO:0003323)2.40201050
112G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.40045041
113cell proliferation involved in metanephros development (GO:0072203)2.39999093
114dorsal/ventral axis specification (GO:0009950)2.39246257
115adherens junction assembly (GO:0034333)2.38872956
116kidney morphogenesis (GO:0060993)2.38654556
117cell migration involved in sprouting angiogenesis (GO:0002042)2.38476753
118blood vessel maturation (GO:0001955)2.38467793
119establishment of monopolar cell polarity (GO:0061162)2.37143877
120establishment or maintenance of monopolar cell polarity (GO:0061339)2.37143877
121maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.36700921
122cytoplasmic mRNA processing body assembly (GO:0033962)2.35070233
123histone H3-K9 demethylation (GO:0033169)2.34444632
124innervation (GO:0060384)2.34310027
125morphogenesis of an epithelial sheet (GO:0002011)2.33713563
126regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.32132591
127negative regulation of chondrocyte differentiation (GO:0032331)2.32100091
128regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.31368593
129suckling behavior (GO:0001967)2.31108553
130regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.30444603
131pre-miRNA processing (GO:0031054)2.30395099
132cell communication involved in cardiac conduction (GO:0086065)2.30305326
133regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.30277339
134hair follicle development (GO:0001942)2.29937150
135Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.29692714
136extracellular matrix disassembly (GO:0022617)2.29597470
137patterning of blood vessels (GO:0001569)2.28909076
138negative regulation of histone methylation (GO:0031061)2.28889726
139regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.28809143
140paraxial mesoderm development (GO:0048339)2.28269144
141genitalia morphogenesis (GO:0035112)2.27870083
142heart valve morphogenesis (GO:0003179)2.27731702
143regulation of non-canonical Wnt signaling pathway (GO:2000050)2.27393906
144embryonic heart tube development (GO:0035050)2.26989840
145epithelial to mesenchymal transition (GO:0001837)2.26808049
146negative regulation of catenin import into nucleus (GO:0035414)2.25790806
147interkinetic nuclear migration (GO:0022027)2.24529432
148regulation of cell fate specification (GO:0042659)2.24010798
149negative regulation of glycogen biosynthetic process (GO:0045719)2.23790365
150artery morphogenesis (GO:0048844)2.23740992
151regulation of establishment of planar polarity (GO:0090175)2.23596687
152proximal/distal pattern formation (GO:0009954)2.23550453
153regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.23357107
154negative regulation of axon extension involved in axon guidance (GO:0048843)2.23127282
155anatomical structure arrangement (GO:0048532)2.22296074
156cardiac epithelial to mesenchymal transition (GO:0060317)2.21926023
157mesodermal cell differentiation (GO:0048333)2.21833788
158aorta morphogenesis (GO:0035909)2.21818139
159positive regulation of dendritic spine morphogenesis (GO:0061003)2.20543530
160sprouting angiogenesis (GO:0002040)2.18829305
161endothelial cell differentiation (GO:0045446)2.18708401
162* insulin-like growth factor receptor signaling pathway (GO:0048009)2.18209015
163embryonic eye morphogenesis (GO:0048048)2.18149544
164collagen fibril organization (GO:0030199)2.17650129
165mesenchymal cell differentiation (GO:0048762)2.17631059
166neuronal stem cell maintenance (GO:0097150)2.17246135
167glandular epithelial cell development (GO:0002068)2.17169674
168facial nerve structural organization (GO:0021612)2.16485736
169blood vessel morphogenesis (GO:0048514)2.16073018
170head development (GO:0060322)2.15120016
171gland morphogenesis (GO:0022612)2.14081252
172positive regulation of epithelial to mesenchymal transition (GO:0010718)2.14007139
173nephron tubule morphogenesis (GO:0072078)2.13259311
174nephron epithelium morphogenesis (GO:0072088)2.13259311
175renal tubule morphogenesis (GO:0061333)2.12506446
176hemidesmosome assembly (GO:0031581)13.3762495

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.00709472
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.64877102
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.50005839
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.47509859
5WT1_19549856_ChIP-ChIP_CCG9911_Human2.43378894
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.37819151
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.29560151
8* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.29531686
9* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.25635560
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.20111679
11EZH2_22144423_ChIP-Seq_EOC_Human2.19572412
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.17820276
13GBX2_23144817_ChIP-Seq_PC3_Human2.15423165
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.10427339
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08583066
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03758311
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03758311
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98070553
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97003901
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.94557132
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87916850
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87120286
23* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.85720650
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.85530756
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.84420890
26* EP300_21415370_ChIP-Seq_HL-1_Mouse1.84089489
27* ISL1_27105846_Chip-Seq_CPCs_Mouse1.80645494
28* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77671805
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.76282156
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74871827
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74287188
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.73714243
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.71602904
34* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71322885
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70605308
36* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.70190842
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.70056148
38ZNF263_19887448_ChIP-Seq_K562_Human1.66084469
39* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.62681378
40* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.62681378
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.62628895
42RING1B_27294783_Chip-Seq_NPCs_Mouse1.57240750
43TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56402550
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.56168179
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.55019023
46* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53715222
47* PIAS1_25552417_ChIP-Seq_VCAP_Human1.53403092
48* AHR_22903824_ChIP-Seq_MCF-7_Human1.52907695
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48987730
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47567095
51TCF4_18268006_ChIP-ChIP_LS174T_Human1.46619162
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.46022376
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45715337
54* ARNT_22903824_ChIP-Seq_MCF-7_Human1.45638135
55* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.44011533
56* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43681605
57* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38328913
58TP53_16413492_ChIP-PET_HCT116_Human1.37308076
59TP53_18474530_ChIP-ChIP_U2OS_Human1.36754064
60* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35372498
61AR_21572438_ChIP-Seq_LNCaP_Human1.35191843
62ZNF274_21170338_ChIP-Seq_K562_Hela1.34179345
63* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32137460
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32104485
65TP63_23658742_ChIP-Seq_EP156T_Human1.31630370
66FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30372437
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.29885245
68* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29342074
69CJUN_26792858_Chip-Seq_BT549_Human1.28880694
70SMAD4_21799915_ChIP-Seq_A2780_Human1.28788268
71BRD4_25478319_ChIP-Seq_HGPS_Human1.28068451
72* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27593853
73FUS_26573619_Chip-Seq_HEK293_Human1.26638306
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.26271673
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.25059753
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24950655
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23812210
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23296066
79TAF15_26573619_Chip-Seq_HEK293_Human1.22419242
80* IGF1R_20145208_ChIP-Seq_DFB_Human1.22236527
81* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21360051
82P300_19829295_ChIP-Seq_ESCs_Human1.20603858
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.19853809
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.18795447
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18022210
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17988130
87* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17922428
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17390237
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17054150
90* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16025489
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.15167290
92CLOCK_20551151_ChIP-Seq_293T_Human1.14196568
93* RNF2_27304074_Chip-Seq_NSC_Mouse1.14079618
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14054604
95SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13990955
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13545604
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13440455
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13433224
99* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12945505
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12745314
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12623253
102ESR1_21235772_ChIP-Seq_MCF-7_Human1.12393824
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11951088
104* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11795285
105P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09520442
106EWS_26573619_Chip-Seq_HEK293_Human1.09498637
107AR_21909140_ChIP-Seq_LNCAP_Human1.09319868
108EGR1_19374776_ChIP-ChIP_THP-1_Human1.08201419
109* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06102631
110SMAD3_21741376_ChIP-Seq_HESCs_Human1.05940984
111TP53_20018659_ChIP-ChIP_R1E_Mouse1.05519676
112DROSHA_22980978_ChIP-Seq_HELA_Human1.04802239
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04154396
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03966222
115CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03206023
116ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02874670
117TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02678841
118TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02553931
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02537915
120* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01801055
121BCAT_22108803_ChIP-Seq_LS180_Human1.01530091
122* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01127854
123* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99750372
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98161536
125STAT3_23295773_ChIP-Seq_U87_Human0.98035904
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97765795
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97765795
128* RXR_22108803_ChIP-Seq_LS180_Human0.97601105
129UBF1/2_26484160_Chip-Seq_HMECs_Human0.95677929
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.93086431
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92050797
132KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90829733
133PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90697820
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88855995
135* FOXA2_19822575_ChIP-Seq_HepG2_Human0.88651754
136PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86455791
137ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86385591
138MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82833969
139CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.82410825
140KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82325896
141GF1B_26923725_Chip-Seq_HPCs_Mouse0.81934320
142POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.81816525
143* AR_19668381_ChIP-Seq_PC3_Human0.81729629
144ELK4_26923725_Chip-Seq_MESODERM_Mouse0.81531349

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.27272594
2MP0001879_abnormal_lymphatic_vessel2.62195430
3MP0010678_abnormal_skin_adnexa2.62070529
4MP0004272_abnormal_basement_membrane2.56614557
5MP0010234_abnormal_vibrissa_follicle2.52850795
6MP0003566_abnormal_cell_adhesion2.40587986
7MP0000467_abnormal_esophagus_morphology2.36987166
8MP0005503_abnormal_tendon_morphology2.22443660
9MP0002060_abnormal_skin_morphology2.20090331
10MP0005623_abnormal_meninges_morphology2.16491026
11MP0001849_ear_inflammation2.14312530
12MP0010030_abnormal_orbit_morphology2.14132819
13MP0002938_white_spotting2.10526099
14MP0009250_abnormal_appendicular_skeleto2.04778172
15MP0010368_abnormal_lymphatic_system2.04388131
16MP0003941_abnormal_skin_development2.02047895
17MP0000049_abnormal_middle_ear1.98427524
18MP0003385_abnormal_body_wall1.97011688
19MP0004264_abnormal_extraembryonic_tissu1.95891973
20MP0002796_impaired_skin_barrier1.91400522
21MP0003942_abnormal_urinary_system1.90208718
22MP0003705_abnormal_hypodermis_morpholog1.83897930
23MP0000569_abnormal_digit_pigmentation1.82530319
24MP0005257_abnormal_intraocular_pressure1.78939233
25MP0003935_abnormal_craniofacial_develop1.74144959
26MP0003279_aneurysm1.72512637
27* MP0001216_abnormal_epidermal_layer1.70783628
28MP0008438_abnormal_cutaneous_collagen1.68380419
29MP0006054_spinal_hemorrhage1.67918511
30MP0009379_abnormal_foot_pigmentation1.67837651
31MP0003755_abnormal_palate_morphology1.66211851
32MP0001188_hyperpigmentation1.66187032
33MP0003283_abnormal_digestive_organ1.63561012
34MP0005248_abnormal_Harderian_gland1.62209144
35MP0009278_abnormal_bone_marrow1.56249695
36MP0000534_abnormal_ureter_morphology1.56245505
37MP0001346_abnormal_lacrimal_gland1.55881189
38MP0003937_abnormal_limbs/digits/tail_de1.54682136
39MP0000516_abnormal_urinary_system1.54191518
40MP0005367_renal/urinary_system_phenotyp1.54191518
41MP0002249_abnormal_larynx_morphology1.54011049
42MP0003890_abnormal_embryonic-extraembry1.53449289
43MP0000537_abnormal_urethra_morphology1.48699617
44MP0004381_abnormal_hair_follicle1.45272722
45* MP0000377_abnormal_hair_follicle1.42312034
46MP0000428_abnormal_craniofacial_morphol1.41095242
47* MP0002116_abnormal_craniofacial_bone1.40933878
48MP0000566_synostosis1.40844048
49MP0000762_abnormal_tongue_morphology1.38907624
50MP0001958_emphysema1.38162628
51MP0005409_darkened_coat_color1.37907568
52* MP0003122_maternal_imprinting1.37618357
53MP0003943_abnormal_hepatobiliary_system1.36596214
54MP0004808_abnormal_hematopoietic_stem1.34526651
55MP0003787_abnormal_imprinting1.33921629
56MP0003453_abnormal_keratinocyte_physiol1.33665398
57MP0010771_integument_phenotype1.33210316
58MP0003315_abnormal_perineum_morphology1.30588564
59MP0002177_abnormal_outer_ear1.29803696
60MP0002233_abnormal_nose_morphology1.29727332
61MP0001270_distended_abdomen1.29124916
62MP0009384_cardiac_valve_regurgitation1.27991841
63* MP0002896_abnormal_bone_mineralization1.27677119
64MP0000432_abnormal_head_morphology1.26934332
65MP0002282_abnormal_trachea_morphology1.25740663
66MP0002234_abnormal_pharynx_morphology1.25705874
67MP0002009_preneoplasia1.24731684
68MP0009780_abnormal_chondrocyte_physiolo1.23622488
69MP0002925_abnormal_cardiovascular_devel1.23596637
70MP0009053_abnormal_anal_canal1.23469315
71MP0004270_analgesia1.23421165
72MP0005501_abnormal_skin_physiology1.21920461
73MP0000427_abnormal_hair_cycle1.21288572
74MP0008789_abnormal_olfactory_epithelium1.20521470
75MP0000163_abnormal_cartilage_morphology1.20504958
76MP0001299_abnormal_eye_distance/1.20317641
77MP0000538_abnormal_urinary_bladder1.19733267
78MP0003878_abnormal_ear_physiology1.19063262
79MP0005377_hearing/vestibular/ear_phenot1.19063262
80MP0004858_abnormal_nervous_system1.17896614
81* MP0005508_abnormal_skeleton_morphology1.17770033
82MP0002109_abnormal_limb_morphology1.17767745
83* MP0003121_genomic_imprinting1.17694116
84MP0003300_gastrointestinal_ulcer1.16619164
85MP0006072_abnormal_retinal_apoptosis1.15862594
86MP0002932_abnormal_joint_morphology1.15384358
87MP0005275_abnormal_skin_tensile1.15336237
88MP0000767_abnormal_smooth_muscle1.13495909
89MP0003115_abnormal_respiratory_system1.13464206
90MP0002697_abnormal_eye_size1.13225435
91MP0004134_abnormal_chest_morphology1.12966099
92MP0001286_abnormal_eye_development1.12373900
93* MP0002108_abnormal_muscle_morphology1.12073170
94MP0005171_absent_coat_pigmentation1.11903674
95MP0001293_anophthalmia1.11859984
96MP0002928_abnormal_bile_duct1.11809280
97MP0000462_abnormal_digestive_system1.09727091
98MP0002877_abnormal_melanocyte_morpholog1.08972449
99MP0002115_abnormal_skeleton_extremities1.06329214
100MP0000631_abnormal_neuroendocrine_gland1.04418849
101MP0004233_abnormal_muscle_weight1.01437823
102MP0004885_abnormal_endolymph1.00399896
103MP0006292_abnormal_olfactory_placode0.99767109
104MP0000627_abnormal_mammary_gland0.98134078
105MP0000613_abnormal_salivary_gland0.97965326
106MP0010352_gastrointestinal_tract_polyps0.97602540
107MP0005499_abnormal_olfactory_system0.97396726
108MP0005394_taste/olfaction_phenotype0.97396726
109MP0004782_abnormal_surfactant_physiolog0.96613726
110MP0005076_abnormal_cell_differentiation0.95332674
111MP0004197_abnormal_fetal_growth/weight/0.93678792
112MP0002098_abnormal_vibrissa_morphology0.93372548
113MP0005187_abnormal_penis_morphology0.93365408
114MP0002084_abnormal_developmental_patter0.93021620
115MP0002111_abnormal_tail_morphology0.89406457
116* MP0002113_abnormal_skeleton_development0.89066660
117MP0002295_abnormal_pulmonary_circulatio0.87028919
118* MP0002081_perinatal_lethality0.86461208
119MP0002909_abnormal_adrenal_gland0.86441225
120MP0003123_paternal_imprinting0.85810565
121MP0000678_abnormal_parathyroid_gland0.85104282
122MP0004484_altered_response_of0.84490364
123MP0002114_abnormal_axial_skeleton0.84042145
124MP0003091_abnormal_cell_migration0.83611032
125* MP0009931_abnormal_skin_appearance0.83524308
126MP0000778_abnormal_nervous_system0.82887587
127* MP0000733_abnormal_muscle_development0.82512908
128MP0002128_abnormal_blood_circulation0.81456396
129MP0003119_abnormal_digestive_system0.81217836
130MP0003045_fibrosis0.80992875
131* MP0010630_abnormal_cardiac_muscle0.78659590
132MP0000383_abnormal_hair_follicle0.78156202
133MP0005023_abnormal_wound_healing0.77433356
134* MP0001784_abnormal_fluid_regulation0.77067935
135MP0002092_abnormal_eye_morphology0.76845417
136MP0001614_abnormal_blood_vessel0.76546763
137MP0003828_pulmonary_edema0.76074641
138MP0002751_abnormal_autonomic_nervous0.75457501
139* MP0003861_abnormal_nervous_system0.74444309
140MP0000647_abnormal_sebaceous_gland0.72868200
141MP0001340_abnormal_eyelid_morphology0.70209940
142* MP0009672_abnormal_birth_weight0.69867671
143MP0002184_abnormal_innervation0.69495065
144MP0005083_abnormal_biliary_tract0.69350709
145* MP0009703_decreased_birth_body0.68151344
146MP0002085_abnormal_embryonic_tissue0.66741623
147MP0000367_abnormal_coat/_hair0.64828594
148MP0003984_embryonic_growth_retardation0.64760038
149MP0008932_abnormal_embryonic_tissue0.64540397
150MP0002088_abnormal_embryonic_growth/wei0.64176086
151* MP0001177_atelectasis0.62386973
152MP0001661_extended_life_span0.62334979
153* MP0003936_abnormal_reproductive_system0.62111862
154MP0005380_embryogenesis_phenotype0.60258261
155MP0001672_abnormal_embryogenesis/_devel0.60258261

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)7.53201979
2Onycholysis (HP:0001806)6.92296354
3Fragile nails (HP:0001808)6.84774383
4Plantar hyperkeratosis (HP:0007556)5.62704999
5Abnormality of nail color (HP:0100643)5.00452072
6Right ventricular cardiomyopathy (HP:0011663)4.45125281
7Hypoplasia of dental enamel (HP:0006297)3.89654947
8Pili torti (HP:0003777)3.68172577
9Alopecia of scalp (HP:0002293)3.62027950
10Short 4th metacarpal (HP:0010044)3.57048000
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.57048000
12Thick nail (HP:0001805)3.44663363
13Pterygium (HP:0001059)3.38854523
14Nail dystrophy (HP:0008404)3.38638739
15Palmoplantar hyperkeratosis (HP:0000972)2.98562389
16Esophageal atresia (HP:0002032)2.91883740
17Ridged nail (HP:0001807)2.91519741
18Natal tooth (HP:0000695)2.90182466
19Palmar hyperkeratosis (HP:0010765)2.86726874
20Abnormality of the nasal septum (HP:0000419)2.85586636
21Sparse scalp hair (HP:0002209)2.81076068
22Selective tooth agenesis (HP:0001592)2.79594758
23Midline defect of the nose (HP:0004122)2.71346830
24Absent eyelashes (HP:0000561)2.65991638
25Vertebral arch anomaly (HP:0008438)2.61360069
26Abnormality of the parietal bone (HP:0002696)2.55980075
27Abnormal hair laboratory examination (HP:0003328)2.55834413
28Advanced eruption of teeth (HP:0006288)2.51814690
29Back pain (HP:0003418)2.46439144
30Abnormality of the 4th metacarpal (HP:0010012)2.41912496
31Woolly hair (HP:0002224)2.40974738
32Morphological abnormality of the middle ear (HP:0008609)2.40210785
33Shallow orbits (HP:0000586)2.40172456
34Septate vagina (HP:0001153)2.39421908
35Laryngomalacia (HP:0001601)2.36076775
36Protrusio acetabuli (HP:0003179)2.33504087
37Mesomelia (HP:0003027)2.32337736
38Hypodontia (HP:0000668)2.28891646
39Abnormal blistering of the skin (HP:0008066)2.28449937
40Hypotrichosis (HP:0001006)2.25344681
41Anonychia (HP:0001798)2.25056807
42Flat acetabular roof (HP:0003180)2.17483519
43Hepatoblastoma (HP:0002884)2.15084950
44Ankyloglossia (HP:0010296)2.13346087
45Asymmetry of the thorax (HP:0001555)2.12754979
46Labial hypoplasia (HP:0000066)2.11292999
47Sparse eyelashes (HP:0000653)2.10167552
48Neonatal short-limb short stature (HP:0008921)2.09866348
49Premature rupture of membranes (HP:0001788)2.09857854
50Abnormality of permanent molar morphology (HP:0011071)2.09505117
51Abnormality of the dental root (HP:0006486)2.09505117
52Taurodontia (HP:0000679)2.09505117
53Persistence of primary teeth (HP:0006335)2.09061567
54Abnormality of the axillary hair (HP:0100134)2.06114474
55Abnormality of secondary sexual hair (HP:0009888)2.06114474
56Broad metatarsal (HP:0001783)2.03457863
57Abnormality of the salivary glands (HP:0010286)2.03411785
58Broad thumb (HP:0011304)2.02937752
59Absent eyebrow (HP:0002223)2.02708581
60Long eyelashes (HP:0000527)2.02706853
61Renal duplication (HP:0000075)2.01069606
62Chorioretinal atrophy (HP:0000533)1.99982273
63Hypoplastic ischia (HP:0003175)1.98940000
64Abnormality of the fingertips (HP:0001211)1.98382335
65Cutaneous finger syndactyly (HP:0010554)1.97763180
66Aortic aneurysm (HP:0004942)1.96361106
67Abnormality of molar (HP:0011077)1.95605151
68Abnormality of molar morphology (HP:0011070)1.95605151
69Narrow palate (HP:0000189)1.95513493
70Atrophic scars (HP:0001075)1.95263501
71Broad face (HP:0000283)1.94479048
72Aortic dissection (HP:0002647)1.92307570
73Abnormality of the distal phalanx of the thumb (HP:0009617)1.91621696
74Abnormality of the right ventricle (HP:0001707)1.91424633
75Macroorchidism (HP:0000053)1.91231618
76Hypoplastic female external genitalia (HP:0012815)1.90263199
77Gastrointestinal atresia (HP:0002589)1.90124759
78Vitreoretinal degeneration (HP:0000655)1.89630617
79Volvulus (HP:0002580)1.88918611
80Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88863938
81Oligodontia (HP:0000677)1.88597395
82Spinal cord lesions (HP:0100561)1.88436087
83Syringomyelia (HP:0003396)1.88436087
84Absent frontal sinuses (HP:0002688)1.87468536
85Abnormality of carpal bone ossification (HP:0006257)1.87383762
86Trigonocephaly (HP:0000243)1.86283493
87Aplasia cutis congenita (HP:0001057)1.82727326
88Popliteal pterygium (HP:0009756)1.82023928
89Amelogenesis imperfecta (HP:0000705)1.81459512
90Abnormality of the dental pulp (HP:0006479)1.80038517
91Skull defect (HP:0001362)1.79257996
92Cutaneous syndactyly (HP:0012725)1.78233301
93Broad long bones (HP:0005622)1.76576971
94Short nail (HP:0001799)1.76567543
95Broad toe (HP:0001837)1.76431508
96Hypoplastic labia majora (HP:0000059)1.73768845
97Broad finger (HP:0001500)1.72285495
98Bronchomalacia (HP:0002780)1.71593804
99Broad phalanx (HP:0006009)1.71512995
100Overgrowth (HP:0001548)1.71431297
101Deep philtrum (HP:0002002)1.70764528
102Abnormality of the frontal sinuses (HP:0002687)1.68861099
103Neurofibrillary tangles (HP:0002185)1.68030299
104Broad phalanges of the hand (HP:0009768)1.67757732
105Abnormality of the ischium (HP:0003174)1.67484111
106Drooling (HP:0002307)1.67099230
107Lip pit (HP:0100267)1.67045714
108Ankle contracture (HP:0006466)1.66692326
109Anal stenosis (HP:0002025)1.66513179
110Ectropion (HP:0000656)1.66477727
111Abnormality of the lacrimal duct (HP:0011481)1.66408775
112Hip contracture (HP:0003273)1.65550374
113Hypoplasia of the maxilla (HP:0000327)1.65094557
114Ureteral stenosis (HP:0000071)1.64831360
115Aqueductal stenosis (HP:0002410)1.64459044
116Increased number of teeth (HP:0011069)1.63816279
117Papillary thyroid carcinoma (HP:0002895)1.63443511
118Abnormal ossification of hand bones (HP:0005921)1.63112400
119Corneal erosion (HP:0200020)1.62920612
120Spinal rigidity (HP:0003306)1.62545002
121Joint laxity (HP:0001388)1.62176432
122Subacute progressive viral hepatitis (HP:0006572)1.61961479
123Abnormality of the incisor (HP:0000676)1.61844923
124Abnormality of the pubic bones (HP:0003172)1.61667703
125Vertebral hypoplasia (HP:0008417)1.61385027
126Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.61385027
127Epiphyseal dysplasia (HP:0002656)1.61240617
128Cerebral inclusion bodies (HP:0100314)1.61211988
129Abnormality of incisor morphology (HP:0011063)1.60869015
130Limited hip movement (HP:0008800)1.60624289
131Vascular tortuosity (HP:0004948)1.60189278
132Supernumerary ribs (HP:0005815)1.59772096
133Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.59577767
134Abnormality of the nasolacrimal system (HP:0000614)1.59561919
135Abnormality of the phalanges of the hallux (HP:0010057)1.59096002
136Abnormal hand bone ossification (HP:0010660)1.58881987
137Germ cell neoplasia (HP:0100728)1.58791089
138Absent hair (HP:0002298)1.58562570
139Carious teeth (HP:0000670)1.58517237
140Bladder diverticulum (HP:0000015)1.57959029
141Down-sloping shoulders (HP:0200021)1.57297636
142Abnormal number of incisors (HP:0011064)1.57161222
143Arterial tortuosity (HP:0005116)1.56549872
144Abnormality of oral frenula (HP:0000190)1.54705301
145Ureteral obstruction (HP:0006000)1.54354483
146Abnormality of the labia majora (HP:0012881)1.54131434
147Vertebral clefting (HP:0008428)1.53916079
148Broad hallux (HP:0010055)1.53637922
149Mild short stature (HP:0003502)1.53289089
150Cerebral aneurysm (HP:0004944)1.53261436
151Exostoses (HP:0100777)1.52425178
152Tracheomalacia (HP:0002779)1.52146513
153Wide anterior fontanel (HP:0000260)1.52007663
154High anterior hairline (HP:0009890)1.51292436
155Renal hypoplasia (HP:0000089)1.51209332
156Cervical subluxation (HP:0003308)1.50253980
157Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.50121418
158Microglossia (HP:0000171)1.50028101
159Pulmonary artery stenosis (HP:0004415)1.49978248
160Buphthalmos (HP:0000557)1.49509107
161Bowel diverticulosis (HP:0005222)1.49009245
162Hip dysplasia (HP:0001385)1.48717343
163Follicular hyperkeratosis (HP:0007502)1.47545885
164Metaphyseal dysplasia (HP:0100255)1.47428589
165Bifid tongue (HP:0010297)1.47420168
166Dental malocclusion (HP:0000689)1.47197146
167Fragile skin (HP:0001030)1.46711278
168Tibial bowing (HP:0002982)1.45979350
169Decreased skull ossification (HP:0004331)1.45648809
170Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.45451009
171Short 1st metacarpal (HP:0010034)1.44797163
172Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.44797163
173Broad palm (HP:0001169)1.44782392
174Dislocated radial head (HP:0003083)1.44740742
175Soft skin (HP:0000977)1.44638629
176Excessive salivation (HP:0003781)1.44476357
177Short middle phalanx of the 5th finger (HP:0004220)1.44241893
178Congenital stationary night blindness (HP:0007642)1.44078472
179Abnormality of the phalanges of the 2nd finger (HP:0009541)1.43585298
180Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.43490066

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.82288808
2NTRK13.09117698
3INSRR2.96897949
4LATS12.60723662
5CAMK1G2.25967652
6KDR2.23783205
7DMPK2.05470004
8AKT32.02901690
9MST1R2.02036877
10NUAK11.98073752
11PDGFRA1.97094888
12MET1.96869824
13CDK121.89100774
14ERBB31.85870191
15MKNK21.83908562
16DDR21.82612704
17TSSK61.80736914
18EPHA31.80465001
19TAOK11.78797011
20SRPK11.75750100
21EPHB21.75718308
22GRK11.68375441
23MKNK11.64805210
24CAMK1D1.60763249
25SGK21.56273575
26NLK1.51742477
27BRD41.50085429
28TNIK1.48940094
29SMG11.46522231
30HIPK21.44861687
31TRPM71.37074919
32EEF2K1.29169879
33FER1.27883689
34TGFBR11.27486088
35EPHA21.25596954
36WNK11.22970859
37SGK31.22702673
38MAP3K91.21138544
39MARK11.20467391
40MAPK151.18921391
41TTN1.16540418
42STK31.16237278
43CDK91.12761000
44PTK21.11496192
45SIK21.08478008
46WNK41.07571580
47FRK1.07189820
48SIK11.05930000
49RIPK11.04946228
50SGK2231.03820471
51SGK4941.03820471
52LATS21.02891639
53ZAK1.01062863
54PAK21.00081381
55MARK20.98538629
56TRIB30.97330131
57MAPK130.96347413
58CSNK1A1L0.96302789
59PIK3CA0.95911746
60PRKD20.94991190
61MTOR0.94817347
62STK240.94515557
63TEC0.94366235
64TGFBR20.92884951
65PASK0.92166170
66ERN10.91873451
67PDGFRB0.89926276
68CDC42BPA0.89913213
69CASK0.89702139
70EPHA40.89102620
71ROCK20.87237846
72PRKD30.86876865
73PKN20.86286066
74RPS6KB20.85496948
75BMPR1B0.83085533
76CAMK40.82204130
77STK38L0.80768916
78PRKCE0.79583485
79PTK60.79313465
80PAK40.77963131
81TAOK30.72465383
82PRKCH0.71819242
83PRKAA10.70588240
84CDK80.70186181
85PNCK0.68444946
86NEK60.68038055
87ROCK10.67346868
88MYLK0.67108438
89FGFR30.66979893
90PRKCZ0.64440445
91ICK0.64431592
92RPS6KB10.63692059
93FGFR20.63339193
94STK380.62265416
95MELK0.61649218
96STK110.61289842
97KSR10.61089955
98EPHB10.59002941
99SIK30.58396880
100WNK30.57993803
101GSK3A0.57631500
102SGK10.56570625
103PTK2B0.56221044
104PAK30.56068004
105CDK30.55254939
106CDK60.54897990
107UHMK10.54227384
108FLT30.54129398
109TRIM280.53990182
110CHUK0.53825746
111BCR0.53750287
112ERBB20.53718064
113MAPK140.52868471
114AKT10.52682013
115TTK0.52085259
116FGFR10.51111120
117IRAK10.49911876
118MAPKAPK50.49127832
119MAP3K70.48094525
120CAMK10.47483299
121RPS6KA20.46765039
122ADRBK10.46195786
123RPS6KA10.46042483
124YES10.45952683
125DYRK1B0.45907319
126MAPK90.45797001
127MAPK100.44976701
128PLK20.44974966
129ATM0.44657435
130PRKAA20.44167569
131CSNK1G10.43871152
132GSK3B0.43125517
133MAPK10.42979247
134PRKCI0.42663913
135MAPK80.42270869
136MAP3K20.41413632
137MAPKAPK30.41129185
138PRKD10.40955289
139CSNK1E0.39526711
140MAP2K10.36422003
141ERBB40.32032371
142PRKDC0.31281927

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001002.84417532
2Phototransduction_Homo sapiens_hsa047442.08473366
3Fatty acid biosynthesis_Homo sapiens_hsa000612.02498526
4Basal cell carcinoma_Homo sapiens_hsa052171.95779320
5ECM-receptor interaction_Homo sapiens_hsa045121.91896344
6* Adherens junction_Homo sapiens_hsa045201.87464212
7Hedgehog signaling pathway_Homo sapiens_hsa043401.71590228
8* Focal adhesion_Homo sapiens_hsa045101.65039803
9TGF-beta signaling pathway_Homo sapiens_hsa043501.57942411
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.57426596
11Hippo signaling pathway_Homo sapiens_hsa043901.57044028
12N-Glycan biosynthesis_Homo sapiens_hsa005101.55472535
13Wnt signaling pathway_Homo sapiens_hsa043101.53118041
14Dilated cardiomyopathy_Homo sapiens_hsa054141.49426566
15MicroRNAs in cancer_Homo sapiens_hsa052061.41724741
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.40401650
17Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.39535865
18Notch signaling pathway_Homo sapiens_hsa043301.36924893
19* Proteoglycans in cancer_Homo sapiens_hsa052051.33586545
20Axon guidance_Homo sapiens_hsa043601.33457830
21Melanogenesis_Homo sapiens_hsa049161.31248639
22* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.28117542
23* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26590677
24Insulin secretion_Homo sapiens_hsa049111.25716641
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23479359
26Protein digestion and absorption_Homo sapiens_hsa049741.21608786
27Small cell lung cancer_Homo sapiens_hsa052221.21401116
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.21391523
29Chronic myeloid leukemia_Homo sapiens_hsa052201.20070947
30* Prostate cancer_Homo sapiens_hsa052151.16797373
31* Pathways in cancer_Homo sapiens_hsa052001.13175854
32* Rap1 signaling pathway_Homo sapiens_hsa040151.12502656
33* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.11790530
34Endometrial cancer_Homo sapiens_hsa052131.11284890
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07767237
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06330592
37Colorectal cancer_Homo sapiens_hsa052101.06307563
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05402577
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05398347
40Inositol phosphate metabolism_Homo sapiens_hsa005621.04898082
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02512091
42Tight junction_Homo sapiens_hsa045301.01331049
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.00724397
44Cholinergic synapse_Homo sapiens_hsa047251.00104453
45Estrogen signaling pathway_Homo sapiens_hsa049151.00057196
46Cocaine addiction_Homo sapiens_hsa050300.99464005
47Circadian entrainment_Homo sapiens_hsa047130.99363164
48cAMP signaling pathway_Homo sapiens_hsa040240.95352002
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94141080
50Protein export_Homo sapiens_hsa030600.94067359
51Glucagon signaling pathway_Homo sapiens_hsa049220.93448610
52Dorso-ventral axis formation_Homo sapiens_hsa043200.92926080
53* Melanoma_Homo sapiens_hsa052180.91131491
54Olfactory transduction_Homo sapiens_hsa047400.91103299
55Gastric acid secretion_Homo sapiens_hsa049710.90296628
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90271448
57Sphingolipid metabolism_Homo sapiens_hsa006000.90245499
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89601191
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89379157
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87568352
61HTLV-I infection_Homo sapiens_hsa051660.86549395
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.85939233
63Amoebiasis_Homo sapiens_hsa051460.85463955
64Renal cell carcinoma_Homo sapiens_hsa052110.84477740
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84459175
66Renin secretion_Homo sapiens_hsa049240.84459115
67Lysine degradation_Homo sapiens_hsa003100.84210449
68p53 signaling pathway_Homo sapiens_hsa041150.83660997
69Thyroid hormone synthesis_Homo sapiens_hsa049180.83150859
70Insulin signaling pathway_Homo sapiens_hsa049100.82650666
71* AMPK signaling pathway_Homo sapiens_hsa041520.82585455
72MAPK signaling pathway_Homo sapiens_hsa040100.82556080
73Platelet activation_Homo sapiens_hsa046110.82051592
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81484343
75Serotonergic synapse_Homo sapiens_hsa047260.81247942
76Gap junction_Homo sapiens_hsa045400.81113116
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80445165
78Thyroid cancer_Homo sapiens_hsa052160.80438330
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80367636
80* Ras signaling pathway_Homo sapiens_hsa040140.80348929
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79198929
82* Glioma_Homo sapiens_hsa052140.78652621
83Dopaminergic synapse_Homo sapiens_hsa047280.77856415
84Morphine addiction_Homo sapiens_hsa050320.77771325
85Pancreatic secretion_Homo sapiens_hsa049720.77188265
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76547720
87Oxytocin signaling pathway_Homo sapiens_hsa049210.76329004
88Taste transduction_Homo sapiens_hsa047420.75796493
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.75636080
90Type II diabetes mellitus_Homo sapiens_hsa049300.75404705
91* FoxO signaling pathway_Homo sapiens_hsa040680.74968366
92ErbB signaling pathway_Homo sapiens_hsa040120.74826631
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.74646113
94Pancreatic cancer_Homo sapiens_hsa052120.74438405
95Amphetamine addiction_Homo sapiens_hsa050310.73833497
96Glutamatergic synapse_Homo sapiens_hsa047240.73340463
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67331920
98Choline metabolism in cancer_Homo sapiens_hsa052310.66918567
99Circadian rhythm_Homo sapiens_hsa047100.66726870
100Insulin resistance_Homo sapiens_hsa049310.66489195
101Vitamin digestion and absorption_Homo sapiens_hsa049770.66453695
102GnRH signaling pathway_Homo sapiens_hsa049120.66227346
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.65982447
104* HIF-1 signaling pathway_Homo sapiens_hsa040660.65344156
105mRNA surveillance pathway_Homo sapiens_hsa030150.64495218
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64089948
107* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63991769
108Viral myocarditis_Homo sapiens_hsa054160.63622286
109Prolactin signaling pathway_Homo sapiens_hsa049170.63028122
110ABC transporters_Homo sapiens_hsa020100.62900939
111* Ovarian steroidogenesis_Homo sapiens_hsa049130.62610383
112* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62297108
113Long-term potentiation_Homo sapiens_hsa047200.62191850
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61562595
115Bladder cancer_Homo sapiens_hsa052190.61449057
116Non-small cell lung cancer_Homo sapiens_hsa052230.61288882
117mTOR signaling pathway_Homo sapiens_hsa041500.60661969
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60469928
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60280398
120GABAergic synapse_Homo sapiens_hsa047270.59561347
121Salivary secretion_Homo sapiens_hsa049700.55660668
122Bile secretion_Homo sapiens_hsa049760.53779417
123* Long-term depression_Homo sapiens_hsa047300.51239806
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50920625
125Vibrio cholerae infection_Homo sapiens_hsa051100.49688334
126Fatty acid metabolism_Homo sapiens_hsa012120.44582209
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41496490
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38856455

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