IGF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein carboxylation (GO:0018214)7.56412147
2peptidyl-glutamic acid carboxylation (GO:0017187)7.56412147
3negative regulation of fibrinolysis (GO:0051918)7.32298420
4very-low-density lipoprotein particle assembly (GO:0034379)7.07991543
5plasma lipoprotein particle assembly (GO:0034377)6.95502972
6regulation of fibrinolysis (GO:0051917)6.64886815
7regulation of cholesterol esterification (GO:0010872)6.39034010
8protein-lipid complex assembly (GO:0065005)6.32859366
9regulation of apoptotic cell clearance (GO:2000425)5.82501386
10regulation of protein activation cascade (GO:2000257)5.81200828
11regulation of complement activation (GO:0030449)5.77397985
12low-density lipoprotein particle remodeling (GO:0034374)5.67258682
13protein-lipid complex remodeling (GO:0034368)5.53539432
14macromolecular complex remodeling (GO:0034367)5.53539432
15plasma lipoprotein particle remodeling (GO:0034369)5.53539432
16high-density lipoprotein particle remodeling (GO:0034375)5.35646381
17regulation of plasminogen activation (GO:0010755)5.26265201
18regulation of cholesterol homeostasis (GO:2000188)5.23806493
19plasma lipoprotein particle organization (GO:0071827)5.22142414
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.20122438
21cholesterol efflux (GO:0033344)5.19413811
22blood coagulation, intrinsic pathway (GO:0007597)5.10143159
23intestinal cholesterol absorption (GO:0030299)5.04899789
24protein-lipid complex subunit organization (GO:0071825)4.98479875
25negative regulation of sterol transport (GO:0032372)4.95172598
26negative regulation of cholesterol transport (GO:0032375)4.95172598
27plasma lipoprotein particle clearance (GO:0034381)4.91203341
28reverse cholesterol transport (GO:0043691)4.72212539
29phospholipid efflux (GO:0033700)4.69848637
30bone trabecula formation (GO:0060346)4.56535117
31lung epithelium development (GO:0060428)4.51725615
32polarized epithelial cell differentiation (GO:0030859)4.50127479
33hippo signaling (GO:0035329)4.49949959
34paraxial mesoderm development (GO:0048339)4.43165809
35basement membrane organization (GO:0071711)4.37396040
36planar cell polarity pathway involved in neural tube closure (GO:0090179)4.27953766
37regulation of bile acid biosynthetic process (GO:0070857)4.23099407
38cell proliferation involved in metanephros development (GO:0072203)4.21277974
39fibrinolysis (GO:0042730)4.21172976
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.14033160
41complement activation, alternative pathway (GO:0006957)4.13807873
42regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.10887154
43regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.06654698
44positive regulation of blood coagulation (GO:0030194)3.93000360
45positive regulation of hemostasis (GO:1900048)3.93000360
46negative regulation of lipase activity (GO:0060192)3.90024238
47regulation of cholesterol biosynthetic process (GO:0045540)3.85018871
48embryonic retina morphogenesis in camera-type eye (GO:0060059)3.82094701
49negative regulation of hemostasis (GO:1900047)3.81413936
50negative regulation of blood coagulation (GO:0030195)3.81413936
51insulin-like growth factor receptor signaling pathway (GO:0048009)3.79531106
52neuron projection extension involved in neuron projection guidance (GO:1902284)3.77163724
53axon extension involved in axon guidance (GO:0048846)3.77163724
54mesenchymal cell proliferation (GO:0010463)3.73652471
55negative regulation of chondrocyte differentiation (GO:0032331)3.73598268
56embryonic skeletal joint morphogenesis (GO:0060272)3.72359032
57midgut development (GO:0007494)3.70993846
58G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.69252982
59positive regulation of fatty acid biosynthetic process (GO:0045723)3.67170463
60regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.65823451
61positive regulation of extracellular matrix organization (GO:1903055)3.64622323
62regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.63163572
63chondrocyte development (GO:0002063)3.60817091
64regulation of heart morphogenesis (GO:2000826)3.59867348
65blood vessel maturation (GO:0001955)3.59748603
66lipoprotein metabolic process (GO:0042157)3.59299172
67mesenchyme morphogenesis (GO:0072132)3.56135140
68positive regulation of coagulation (GO:0050820)3.55457708
69mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.55359483
70negative regulation of protein activation cascade (GO:2000258)3.54646321
71chondrocyte proliferation (GO:0035988)3.53763297
72collagen fibril organization (GO:0030199)3.53588833
73cell migration involved in heart development (GO:0060973)3.52627733
74cell proliferation involved in kidney development (GO:0072111)3.52321135
75proline metabolic process (GO:0006560)3.49382716
76negative regulation of coagulation (GO:0050819)3.49197442
77endocardial cushion development (GO:0003197)3.47290960
78intestinal absorption (GO:0050892)3.43722053
79body morphogenesis (GO:0010171)3.39890644
80glomerular filtration (GO:0003094)3.38032275
81embryonic foregut morphogenesis (GO:0048617)3.36072566
82retina vasculature morphogenesis in camera-type eye (GO:0061299)3.34734991
83lymph vessel development (GO:0001945)3.33993017
84cholesterol homeostasis (GO:0042632)3.33394389
85low-density lipoprotein particle clearance (GO:0034383)3.31683040
86negative regulation of wound healing (GO:0061045)3.31192693
87Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.30263173
88notochord development (GO:0030903)3.30112119
89sterol homeostasis (GO:0055092)3.29389277
90protein activation cascade (GO:0072376)3.26289860
91regulation of establishment of planar polarity (GO:0090175)3.26037178
92acylglycerol homeostasis (GO:0055090)3.25569344
93triglyceride homeostasis (GO:0070328)3.25569344
94positive regulation of triglyceride lipase activity (GO:0061365)3.25193426
95positive regulation of lipoprotein lipase activity (GO:0051006)3.25193426
96protein heterotrimerization (GO:0070208)3.24931583
97L-phenylalanine catabolic process (GO:0006559)3.24905105
98erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.24905105
99renal filtration (GO:0097205)3.23972106
100endothelial cell morphogenesis (GO:0001886)3.23743582
101outer ear morphogenesis (GO:0042473)3.23451170
102acute-phase response (GO:0006953)3.23294429
103cardiac myofibril assembly (GO:0055003)3.23141369
104regulation of extracellular matrix organization (GO:1903053)3.20944195
105patterning of blood vessels (GO:0001569)3.18486945
106mesenchyme development (GO:0060485)3.17867384
107sterol transport (GO:0015918)3.17612864
108cholesterol transport (GO:0030301)3.17612864
109* positive regulation of steroid metabolic process (GO:0045940)3.16853321
110endocardial cushion morphogenesis (GO:0003203)3.15890742
111negative regulation of lipid transport (GO:0032369)3.15108049
112diacylglycerol metabolic process (GO:0046339)3.13249832
113regulation of transforming growth factor beta2 production (GO:0032909)3.13079724
114L-phenylalanine metabolic process (GO:0006558)3.12468066
115erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.12468066
116renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.11916208
117gap junction assembly (GO:0016264)3.11888125
118negative regulation of cell fate specification (GO:0009996)3.10874291
119dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.10205702
120head development (GO:0060322)3.10066840
121negative regulation of cartilage development (GO:0061037)3.10044750
122peptidyl-glutamic acid modification (GO:0018200)3.10030378
123regulation of humoral immune response (GO:0002920)3.09451964
124cochlea morphogenesis (GO:0090103)3.08921755
125cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.08364822
126negative regulation of DNA repair (GO:0045738)3.07339614
127glutamate metabolic process (GO:0006536)3.07138168
128regulation of non-canonical Wnt signaling pathway (GO:2000050)3.06171744
1294-hydroxyproline metabolic process (GO:0019471)3.05917373
130positive regulation of epithelial to mesenchymal transition (GO:0010718)3.05405182
131heart morphogenesis (GO:0003007)3.04694619
132gastrulation with mouth forming second (GO:0001702)3.03994758
133negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.03651159
134glucocorticoid receptor signaling pathway (GO:0042921)3.03357448
135fatty acid homeostasis (GO:0055089)3.03024035
136lymphangiogenesis (GO:0001946)3.02671421
137organ formation (GO:0048645)3.01781283
138negative regulation of sodium ion transport (GO:0010766)2.98673017
139vascular endothelial growth factor signaling pathway (GO:0038084)2.98561049
140embryonic hindlimb morphogenesis (GO:0035116)2.98029669
141positive regulation of mesenchymal cell proliferation (GO:0002053)2.97862344
142craniofacial suture morphogenesis (GO:0097094)2.96913512
143hindlimb morphogenesis (GO:0035137)2.96465751
144endothelial tube morphogenesis (GO:0061154)2.95204969
145morphogenesis of an endothelium (GO:0003159)2.95204969
146embryonic cranial skeleton morphogenesis (GO:0048701)2.95086634
147establishment of apical/basal cell polarity (GO:0035089)2.94513392
148response to follicle-stimulating hormone (GO:0032354)2.93785904
149non-canonical Wnt signaling pathway (GO:0035567)2.93220299
150regulation of extracellular matrix disassembly (GO:0010715)2.92918051
151negative regulation of complement activation (GO:0045916)2.92624754
152nephron epithelium morphogenesis (GO:0072088)2.92353203
153nephron tubule morphogenesis (GO:0072078)2.92353203
154negative regulation of fatty acid transport (GO:2000192)2.91804115
155negative regulation of catenin import into nucleus (GO:0035414)2.91048530
156anatomical structure regression (GO:0060033)2.90272225
157endodermal cell differentiation (GO:0035987)2.90267087
158proximal/distal pattern formation (GO:0009954)2.90163927
159positive regulation of cartilage development (GO:0061036)2.89522396
160sequestering of extracellular ligand from receptor (GO:0035581)2.89416842
161negative regulation of embryonic development (GO:0045992)2.89127972
162regulation of fatty acid biosynthetic process (GO:0042304)2.89011301
163phosphate ion homeostasis (GO:0055062)2.88635068
164trivalent inorganic anion homeostasis (GO:0072506)2.88635068
165cell migration involved in sprouting angiogenesis (GO:0002042)2.87650908
166complement activation, classical pathway (GO:0006958)2.87089241
167negative regulation of glycogen biosynthetic process (GO:0045719)2.86568967
168regulation of cardioblast differentiation (GO:0051890)2.85824152
169lipid homeostasis (GO:0055088)2.85086564
170kidney mesenchyme development (GO:0072074)2.84291089
171collagen metabolic process (GO:0032963)2.83578035
172cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.83068226
173positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.82956760
174lateral sprouting from an epithelium (GO:0060601)2.82952599
175trabecula formation (GO:0060343)2.82762205
176pre-miRNA processing (GO:0031054)2.82650151
177regulation of cartilage development (GO:0061035)2.82192122
178dorsal/ventral axis specification (GO:0009950)2.82132298
179mesodermal cell differentiation (GO:0048333)2.81875258
180vasculogenesis (GO:0001570)2.81577214
181response to vitamin A (GO:0033189)2.81515323
182neurotransmitter-gated ion channel clustering (GO:0072578)2.81254175
183heart valve formation (GO:0003188)2.81133757
184convergent extension (GO:0060026)2.80919512
185regulation of chondrocyte differentiation (GO:0032330)2.80520771
186regulation of mesenchymal cell proliferation (GO:0010464)2.80256023
187regulation of stem cell maintenance (GO:2000036)2.80049963
188positive regulation of collagen biosynthetic process (GO:0032967)2.79971546
189endothelium development (GO:0003158)2.77863930
190renal system development (GO:0072001)2.75122324
191negative regulation of vascular permeability (GO:0043116)2.74485488
192collagen catabolic process (GO:0030574)2.74399711
193regulation of cholesterol metabolic process (GO:0090181)2.70634773
194regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.70030934
195positive regulation of wound healing (GO:0090303)2.68153505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.74630610
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.08956724
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.65780453
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.50190984
5FOXA2_19822575_ChIP-Seq_HepG2_Human3.43192566
6ZNF263_19887448_ChIP-Seq_K562_Human3.38475768
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.26408515
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.24749293
9EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse3.24527426
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.18401068
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.18064682
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.12761218
13TP63_19390658_ChIP-ChIP_HaCaT_Human3.03427545
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.97920466
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.93644673
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.91033891
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84325060
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.79324935
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.78548924
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.73017606
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.59300122
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57665745
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.53340261
24* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.48362463
25ZFP281_18757296_ChIP-ChIP_E14_Mouse2.38674224
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.38450903
27WT1_19549856_ChIP-ChIP_CCG9911_Human2.36288626
28CDX2_20551321_ChIP-Seq_CACO-2_Human2.33910778
29CLOCK_20551151_ChIP-Seq_293T_Human2.33415791
30HNF4A_19822575_ChIP-Seq_HepG2_Human2.25970876
31ESR1_15608294_ChIP-ChIP_MCF-7_Human2.25888093
32ELK3_25401928_ChIP-Seq_HUVEC_Human2.16489307
33* TP53_20018659_ChIP-ChIP_R1E_Mouse2.11668963
34ISL1_27105846_Chip-Seq_CPCs_Mouse2.11476312
35E2F7_22180533_ChIP-Seq_HELA_Human2.08942155
36ESR2_21235772_ChIP-Seq_MCF-7_Human2.08382555
37HIF1A_21447827_ChIP-Seq_MCF-7_Human2.07725945
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04460028
39* EED_16625203_ChIP-ChIP_MESCs_Mouse2.03277551
40* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.01323864
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.99254236
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.96762339
43* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.95293361
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.90474835
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87604283
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.84907928
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.83520238
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.81697627
49AR_21909140_ChIP-Seq_LNCAP_Human1.80836253
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77798333
51* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77653536
52* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77653536
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75652988
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74635903
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.74094899
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.72640777
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.72603554
58TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.64348463
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63847081
60FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.63121683
61NFIB_24661679_ChIP-Seq_LUNG_Mouse1.57627451
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.56690114
63BRD4_25478319_ChIP-Seq_HGPS_Human1.55904005
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55529556
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.54644485
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54472191
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53036994
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49497358
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47467586
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46500769
71SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.44961552
72* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41398894
73ESR1_21235772_ChIP-Seq_MCF-7_Human1.39274009
74* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38490490
75MYC_22102868_ChIP-Seq_BL_Human1.37630346
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.37605095
77KDM2B_26808549_Chip-Seq_DND41_Human1.36528677
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36145684
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35050125
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.33627818
81* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33261045
82* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33071710
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32534694
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31907928
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31394391
86KDM2B_26808549_Chip-Seq_K562_Human1.29243660
87KDM2B_26808549_Chip-Seq_JURKAT_Human1.28812997
88GATA4_25053715_ChIP-Seq_YYC3_Human1.26778947
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.26322399
90* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25553880
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24537058
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24537058
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24537058
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24393830
95* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23877967
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.23346274
97GATA6_25053715_ChIP-Seq_YYC3_Human1.23310696
98TBX20_22080862_ChIP-Seq_HEART_Mouse1.22419175
99TBX20_22328084_ChIP-Seq_HEART_Mouse1.22419175
100STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.21167810
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20451664
102* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19877237
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19649268
104* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19590605
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19357877
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18753282
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18630152
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17568933
109DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17048598
110TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16620353
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16085041
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16005452
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.15950872
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15885492
115UBF1/2_26484160_Chip-Seq_HMECs_Human1.14908678
116ESR1_20079471_ChIP-ChIP_T-47D_Human1.14251411
117TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13778103
118SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13293084
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12718806
120WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11897784
121NANOG_21062744_ChIP-ChIP_HESCs_Human1.11639931
122NANOG_16153702_ChIP-ChIP_HESCs_Human1.11374006
123* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10486886
124GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.09651637
125CBX2_27304074_Chip-Seq_ESCs_Mouse1.09465592
126RACK7_27058665_Chip-Seq_MCF-7_Human1.08413059
127POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07856995
128MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06844352
129CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06461042
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03863534
131TCF7_22412390_ChIP-Seq_EML_Mouse1.03346073
132* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03334760
133RUNX1_27514584_Chip-Seq_MCF-7_Human1.03214183
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03175319
135TP53_22127205_ChIP-Seq_IMR90_Human1.01414722
136CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01227653
137E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01181753
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01168131
139SOX2_16153702_ChIP-ChIP_HESCs_Human1.00784738
140ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00722032
141OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00234045
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99604299
143CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97516443
144SMC4_20622854_ChIP-Seq_HELA_Human0.96749243
145FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96162877
146LXR_22292898_ChIP-Seq_THP-1_Human0.95691775
147EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95230646
148CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95219031
149TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92282943
150* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87035169
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86778788
152DROSHA_22980978_ChIP-Seq_HELA_Human0.86209632
153PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85012930
154TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83975669
155PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82352297
156SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80154161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.62511570
2* MP0003122_maternal_imprinting4.46780790
3MP0010368_abnormal_lymphatic_system4.31601538
4MP0005360_urolithiasis4.09883388
5MP0003123_paternal_imprinting3.95873206
6MP0004272_abnormal_basement_membrane3.95474547
7MP0003195_calcinosis3.42940767
8MP0005365_abnormal_bile_salt3.23205945
9MP0003121_genomic_imprinting3.14106026
10MP0009053_abnormal_anal_canal3.09756473
11MP0010030_abnormal_orbit_morphology3.04344154
12MP0008438_abnormal_cutaneous_collagen2.94181578
13MP0000537_abnormal_urethra_morphology2.83576541
14MP0010329_abnormal_lipoprotein_level2.79190813
15MP0003705_abnormal_hypodermis_morpholog2.75267521
16MP0005503_abnormal_tendon_morphology2.69092037
17* MP0003385_abnormal_body_wall2.64576026
18MP0001666_abnormal_nutrient_absorption2.60387195
19MP0001879_abnormal_lymphatic_vessel2.58687178
20MP0005623_abnormal_meninges_morphology2.36414390
21MP0006054_spinal_hemorrhage2.29910610
22MP0009840_abnormal_foam_cell2.09417455
23MP0005409_darkened_coat_color2.09229162
24MP0005377_hearing/vestibular/ear_phenot2.07804271
25MP0003878_abnormal_ear_physiology2.07804271
26MP0009250_abnormal_appendicular_skeleto2.05870494
27MP0003942_abnormal_urinary_system1.93654534
28MP0005451_abnormal_body_composition1.89802549
29MP0002932_abnormal_joint_morphology1.82630155
30MP0003937_abnormal_limbs/digits/tail_de1.80239249
31MP0005085_abnormal_gallbladder_physiolo1.79062546
32MP0003279_aneurysm1.78601373
33* MP0004264_abnormal_extraembryonic_tissu1.75042093
34MP0000733_abnormal_muscle_development1.73801979
35MP0000049_abnormal_middle_ear1.72931516
36MP0000534_abnormal_ureter_morphology1.70529931
37MP0005187_abnormal_penis_morphology1.70329675
38MP0005275_abnormal_skin_tensile1.69726959
39MP0003941_abnormal_skin_development1.69315857
40MP0000428_abnormal_craniofacial_morphol1.68922343
41MP0002249_abnormal_larynx_morphology1.66740318
42MP0005058_abnormal_lysosome_morphology1.65768379
43MP0009780_abnormal_chondrocyte_physiolo1.65118134
44MP0003115_abnormal_respiratory_system1.64295542
45MP0003172_abnormal_lysosome_physiology1.61475194
46MP0003935_abnormal_craniofacial_develop1.60781361
47MP0005167_abnormal_blood-brain_barrier1.59685634
48MP0000003_abnormal_adipose_tissue1.59371382
49MP0002282_abnormal_trachea_morphology1.58441136
50MP0004084_abnormal_cardiac_muscle1.56012113
51MP0004197_abnormal_fetal_growth/weight/1.55978079
52MP0000767_abnormal_smooth_muscle1.51724415
53* MP0003567_abnormal_fetal_cardiomyocyte1.50993751
54MP0002938_white_spotting1.50236447
55MP0005408_hypopigmentation1.48453042
56MP0003119_abnormal_digestive_system1.45707953
57MP0005508_abnormal_skeleton_morphology1.44720300
58MP0003755_abnormal_palate_morphology1.44118581
59MP0003868_abnormal_feces_composition1.40916802
60MP0008875_abnormal_xenobiotic_pharmacok1.39443161
61MP0004233_abnormal_muscle_weight1.36599383
62MP0005076_abnormal_cell_differentiation1.32984027
63MP0003566_abnormal_cell_adhesion1.32970919
64MP0002909_abnormal_adrenal_gland1.31025562
65MP0003283_abnormal_digestive_organ1.27592831
66MP0002925_abnormal_cardiovascular_devel1.26438105
67MP0005367_renal/urinary_system_phenotyp1.22904853
68MP0000516_abnormal_urinary_system1.22904853
69MP0002109_abnormal_limb_morphology1.22571048
70MP0009384_cardiac_valve_regurgitation1.21413845
71MP0006138_congestive_heart_failure1.19063065
72MP0002116_abnormal_craniofacial_bone1.19013438
73MP0000762_abnormal_tongue_morphology1.17753785
74MP0000163_abnormal_cartilage_morphology1.14211747
75MP0000432_abnormal_head_morphology1.13191971
76MP0000609_abnormal_liver_physiology1.12940442
77MP0002115_abnormal_skeleton_extremities1.12747405
78MP0004134_abnormal_chest_morphology1.12236002
79MP0010630_abnormal_cardiac_muscle1.11429484
80MP0001915_intracranial_hemorrhage1.11427501
81MP0002088_abnormal_embryonic_growth/wei1.11320795
82MP0003984_embryonic_growth_retardation1.10880974
83* MP0000639_abnormal_adrenal_gland1.10435153
84MP0002233_abnormal_nose_morphology1.10359467
85MP0002118_abnormal_lipid_homeostasis1.10105033
86MP0003943_abnormal_hepatobiliary_system1.09723449
87* MP0002086_abnormal_extraembryonic_tissu1.09704750
88MP0002896_abnormal_bone_mineralization1.09035324
89MP0003329_amyloid_beta_deposits1.09008119
90MP0002111_abnormal_tail_morphology1.08173825
91MP0002128_abnormal_blood_circulation1.07586261
92MP0001672_abnormal_embryogenesis/_devel1.07072557
93MP0005380_embryogenesis_phenotype1.07072557
94MP0002085_abnormal_embryonic_tissue1.06566993
95MP0001661_extended_life_span1.06309099
96MP0003879_abnormal_hair_cell1.05798353
97MP0009672_abnormal_birth_weight1.05427773
98MP0002084_abnormal_developmental_patter1.03435434
99MP0002697_abnormal_eye_size1.03384618
100MP0001293_anophthalmia1.01913218
101MP0002113_abnormal_skeleton_development1.00478903
102MP0001614_abnormal_blood_vessel1.00218574
103* MP0002114_abnormal_axial_skeleton0.99497944
104MP0001270_distended_abdomen0.98383127
105MP0005220_abnormal_exocrine_pancreas0.98362202
106* MP0000266_abnormal_heart_morphology0.96961755
107MP0002108_abnormal_muscle_morphology0.96209295
108MP0005248_abnormal_Harderian_gland0.96159429
109MP0003315_abnormal_perineum_morphology0.95820422
110MP0002127_abnormal_cardiovascular_syste0.95305613
111MP0004145_abnormal_muscle_electrophysio0.94650139
112MP0001299_abnormal_eye_distance/0.93504607
113MP0001697_abnormal_embryo_size0.93094371
114MP0000566_synostosis0.92976115
115MP0000013_abnormal_adipose_tissue0.92641997
116MP0009697_abnormal_copulation0.91730119
117MP0004858_abnormal_nervous_system0.91515683
118MP0003828_pulmonary_edema0.91438536
119MP0003950_abnormal_plasma_membrane0.89939277
120MP0002132_abnormal_respiratory_system0.88261427
121* MP0009703_decreased_birth_body0.87431590
122MP0003252_abnormal_bile_duct0.84164929
123MP0005332_abnormal_amino_acid0.83054046
124MP0002092_abnormal_eye_morphology0.83046305
125MP0005375_adipose_tissue_phenotype0.82969617
126MP0001958_emphysema0.82785228
127MP0005257_abnormal_intraocular_pressure0.82774614
128MP0000598_abnormal_liver_morphology0.82701492
129MP0001849_ear_inflammation0.81645404
130MP0004087_abnormal_muscle_fiber0.80468676
131MP0003011_delayed_dark_adaptation0.80413160
132MP0000604_amyloidosis0.79785819
133MP0000751_myopathy0.79361367
134MP0005023_abnormal_wound_healing0.77249569
135MP0002933_joint_inflammation0.77083592
136MP0002089_abnormal_postnatal_growth/wei0.77033647
137MP0005670_abnormal_white_adipose0.76826315
138MP0001544_abnormal_cardiovascular_syste0.76539047
139MP0005385_cardiovascular_system_phenoty0.76539047
140MP0001784_abnormal_fluid_regulation0.76469829
141MP0008775_abnormal_heart_ventricle0.76051811
142MP0001730_embryonic_growth_arrest0.75215463
143MP0004019_abnormal_vitamin_homeostasis0.74576313
144MP0002971_abnormal_brown_adipose0.68114957
145MP0009115_abnormal_fat_cell0.66862404
146MP0003183_abnormal_peptide_metabolism0.63477181
147MP0003632_abnormal_nervous_system0.60798226
148MP0005636_abnormal_mineral_homeostasis0.60036120
149* MP0005369_muscle_phenotype0.58360855

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)9.81770321
2Prolonged partial thromboplastin time (HP:0003645)6.76963489
3Joint hemorrhage (HP:0005261)6.25826410
4Protrusio acetabuli (HP:0003179)4.94812262
5Complement deficiency (HP:0004431)4.69236091
6Short 4th metacarpal (HP:0010044)4.62786038
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.62786038
8Shallow orbits (HP:0000586)4.25974861
9Hypobetalipoproteinemia (HP:0003563)4.20846587
10Menorrhagia (HP:0000132)4.18591177
11Abnormality of the 4th metacarpal (HP:0010012)4.12539081
12Abnormality of the common coagulation pathway (HP:0010990)4.10813910
13Hemorrhage of the eye (HP:0011885)3.87338067
14Xanthomatosis (HP:0000991)3.86638861
15Glomerulonephritis (HP:0000099)3.85909942
16Renal duplication (HP:0000075)3.76215711
17Hypercholesterolemia (HP:0003124)3.52978144
18Abnormality of complement system (HP:0005339)3.52001006
19Premature rupture of membranes (HP:0001788)3.50576051
20Systemic lupus erythematosus (HP:0002725)3.26629352
21Broad metatarsal (HP:0001783)3.18444664
22Hepatoblastoma (HP:0002884)3.11899496
23Abnormality of carpal bone ossification (HP:0006257)3.08721756
24Flat acetabular roof (HP:0003180)3.06194854
25Bladder diverticulum (HP:0000015)3.01063952
26Cerebral aneurysm (HP:0004944)3.00377108
27Hypolipoproteinemia (HP:0010981)2.94278648
28Abnormality of aromatic amino acid family metabolism (HP:0004338)2.93574586
29Short 5th finger (HP:0009237)2.88383504
30Small epiphyses (HP:0010585)2.74823890
31Mesomelia (HP:0003027)2.72038186
32Mitral valve prolapse (HP:0001634)2.71417156
33Ankle contracture (HP:0006466)2.66651288
34Deviation of the hallux (HP:0010051)2.64328398
35Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.63523855
36Lymphangioma (HP:0100764)2.62638135
37Hypoplastic ischia (HP:0003175)2.62293887
38Peritonitis (HP:0002586)2.59363552
39Broad alveolar ridges (HP:0000187)2.56002978
40Broad thumb (HP:0011304)2.55258871
41Buphthalmos (HP:0000557)2.51894650
42Diastasis recti (HP:0001540)2.49592790
43Hypoalphalipoproteinemia (HP:0003233)2.49147496
44Short middle phalanx of the 5th finger (HP:0004220)2.46556087
45Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.46357452
46Mitral stenosis (HP:0001718)2.46068960
47Abnormal hand bone ossification (HP:0010660)2.45278239
48Type 1 muscle fiber predominance (HP:0003803)2.42844968
49Alacrima (HP:0000522)2.42666419
50Bronchomalacia (HP:0002780)2.41975466
51Broad toe (HP:0001837)2.41437293
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.41072916
53Hallux valgus (HP:0001822)2.39268494
54Aortic dissection (HP:0002647)2.38799145
55Hip contracture (HP:0003273)2.37435241
56Midline defect of the nose (HP:0004122)2.37240581
57Soft skin (HP:0000977)2.37004547
58Ulnar deviation of the wrist (HP:0003049)2.34467648
59Spontaneous abortion (HP:0005268)2.33307849
60Abnormality of dentin (HP:0010299)2.32987974
61Wide anterior fontanel (HP:0000260)2.30744975
62Abnormality of the lumbar spine (HP:0100712)2.29939929
63Vascular calcification (HP:0004934)2.29867825
64Abnormal tarsal ossification (HP:0008369)2.29489724
65Broad long bones (HP:0005622)2.27336211
66Wrist flexion contracture (HP:0001239)2.25745986
67Vaginal fistula (HP:0004320)2.25223129
68Abnormality of the parietal bone (HP:0002696)2.24842982
69Neonatal death (HP:0003811)2.24095792
70Abnormality of the ischium (HP:0003174)2.23918679
71Purpura (HP:0000979)2.23519428
72Round ear (HP:0100830)2.22742030
73Cardiovascular calcification (HP:0011915)2.22458051
74Abnormality of the nasal septum (HP:0000419)2.22073184
75Vitreoretinal degeneration (HP:0000655)2.21986062
76Broad phalanges of the hand (HP:0009768)2.20584513
77Hypophosphatemic rickets (HP:0004912)2.20571112
78Cutaneous finger syndactyly (HP:0010554)2.19381484
79Acanthocytosis (HP:0001927)2.18735475
80Abnormality of the acetabulum (HP:0003170)2.18215515
81Potter facies (HP:0002009)2.18081198
82Facial shape deformation (HP:0011334)2.18081198
83Broad phalanx (HP:0006009)2.16084132
84Broad finger (HP:0001500)2.15395575
85Abnormal umbilical cord blood vessels (HP:0011403)2.15294725
86Single umbilical artery (HP:0001195)2.15294725
87Abnormality of the fetal cardiovascular system (HP:0010948)2.15294725
88Abnormality of the 2nd finger (HP:0004100)2.15233933
89Neonatal short-limb short stature (HP:0008921)2.13980451
90Syringomyelia (HP:0003396)2.13775720
91Spinal cord lesions (HP:0100561)2.13775720
92Coronal craniosynostosis (HP:0004440)2.12236886
93Abnormality of the distal phalanx of the thumb (HP:0009617)2.11203189
94Abnormality of the phalanges of the hallux (HP:0010057)2.10829850
95Renovascular hypertension (HP:0100817)2.10484145
96Abnormality of the lacrimal duct (HP:0011481)2.10125687
97Skull defect (HP:0001362)2.09090437
98Hyperacusis (HP:0010780)2.08710399
99Blue sclerae (HP:0000592)2.08046574
100Flared iliac wings (HP:0002869)2.08044617
101Exostoses (HP:0100777)2.07957326
102Right ventricular cardiomyopathy (HP:0011663)2.06814336
103Enlarged kidneys (HP:0000105)2.06314443
104Gingival bleeding (HP:0000225)2.05647408
105Epiphyseal dysplasia (HP:0002656)2.05345062
106Abnormality of the intrinsic pathway (HP:0010989)2.04368244
107Limited elbow extension (HP:0001377)2.03964339
108Abnormal delivery (HP:0001787)2.03474070
109Microglossia (HP:0000171)2.03248761
110Subacute progressive viral hepatitis (HP:0006572)2.01513127
111Biconcave vertebral bodies (HP:0004586)2.01152581
112Pterygium (HP:0001059)2.00995387
113Cervical subluxation (HP:0003308)2.00696043
114Choanal stenosis (HP:0000452)1.99977928
115Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.99881517
116Late onset (HP:0003584)1.98849637
117Cutaneous syndactyly (HP:0012725)1.98734545
118Aortic aneurysm (HP:0004942)1.96163641
119Thin bony cortex (HP:0002753)1.96043786
120Pancreatic islet-cell hyperplasia (HP:0004510)1.95649467
121Morphological abnormality of the middle ear (HP:0008609)1.94824486
122Selective tooth agenesis (HP:0001592)1.94730363
123Nephritis (HP:0000123)1.93466781
124Limited hip movement (HP:0008800)1.93288381
125Osteomalacia (HP:0002749)1.93275488
126Decreased lacrimation (HP:0000633)1.92767426
127Follicular hyperkeratosis (HP:0007502)1.92237053
128Dilatation of the ascending aorta (HP:0005111)1.92037392
129Abnormality of the pubic bones (HP:0003172)1.91446295
130Disproportionate tall stature (HP:0001519)1.89882934
131Flat cornea (HP:0007720)1.89567084
132Overgrowth (HP:0001548)1.88330367
133Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.88171676
134Broad ribs (HP:0000885)1.87113353
135Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86881919
136Broad palm (HP:0001169)1.86575313
137Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.86022355
138Trigonocephaly (HP:0000243)1.85706081
139Wormian bones (HP:0002645)1.85197072
140Atrophic scars (HP:0001075)1.83398530
141Esophageal varix (HP:0002040)1.82751997
142Broad hallux (HP:0010055)1.82534969
143Bell-shaped thorax (HP:0001591)1.82057558
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81778089
145Joint laxity (HP:0001388)1.80646186
146Abnormal ossification of hand bones (HP:0005921)1.79944239
147Dislocated radial head (HP:0003083)1.79677001
148Genu recurvatum (HP:0002816)1.79582769
149Bifid scrotum (HP:0000048)1.79219483
150Bowel diverticulosis (HP:0005222)1.78078573
151Hepatocellular carcinoma (HP:0001402)1.77780080
152Distal arthrogryposis (HP:0005684)1.77542856
153Sprengel anomaly (HP:0000912)1.77238359
154Popliteal pterygium (HP:0009756)1.76712671
155Fragile skin (HP:0001030)1.76683982
156Spinal rigidity (HP:0003306)1.76603563
157Hyperlipoproteinemia (HP:0010980)1.76340767
158Increased nuchal translucency (HP:0010880)1.76007292
159Abnormality of the radial head (HP:0003995)1.75891942
160Ulnar bowing (HP:0003031)1.75283061
161Menstrual irregularities (HP:0000858)1.73979313
162Epidermoid cyst (HP:0200040)1.73653100
163Malignant hyperthermia (HP:0002047)1.73546261
164Abnormality of the humeroradial joint (HP:0100744)1.73060979
165Mildly elevated creatine phosphokinase (HP:0008180)1.72675620
166Short phalanx of the thumb (HP:0009660)1.72612815
167Abnormality of the nasolacrimal system (HP:0000614)1.72589175
168Short hallux (HP:0010109)1.71978396
169Supernumerary ribs (HP:0005815)1.70725770
170Bicuspid aortic valve (HP:0001647)1.70649029
171Short middle phalanx of finger (HP:0005819)1.70532022
172Absent epiphyses (HP:0010577)1.69738006
173Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.69738006
174Irregular epiphyses (HP:0010582)1.68743362
175Advanced eruption of teeth (HP:0006288)1.68699617
176Abnormality of the wing of the ilium (HP:0011867)1.67725867
177Skin nodule (HP:0200036)1.66934352
178Cupped ribs (HP:0000887)1.66050580
179Thrombophlebitis (HP:0004418)1.65267102
180Aplasia involving bones of the upper limbs (HP:0009823)1.64837380
181Aplasia of the phalanges of the hand (HP:0009802)1.64837380
182Aplasia involving bones of the extremities (HP:0009825)1.64837380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR46.16613379
2TIE15.20407488
3PKN23.75341989
4FGFR33.67690795
5TRIB33.55708301
6LATS13.28003647
7WNK43.20478551
8DDR23.19382673
9EPHB23.12933901
10MAP3K102.97678258
11KDR2.91284720
12PDGFRA2.73887782
13PTK62.29458187
14LATS22.20316067
15RIPK12.16003711
16TGFBR11.95494951
17CDK121.90814620
18PIK3CA1.79538136
19STK391.70704294
20AKT31.70012370
21PAK41.69355333
22PTK2B1.61598791
23TTN1.59285645
24FGFR11.59258807
25SIK11.53209246
26PTK21.53196530
27TGFBR21.45300662
28EPHA21.43406398
29MKNK11.42616145
30STK31.40839111
31PAK21.35695012
32PLK41.31740977
33DMPK1.29853255
34NEK21.26506044
35MTOR1.24610737
36SIK21.21445032
37MAP3K71.19246248
38CAMK1G1.18083628
39NME11.17703669
40ICK1.15643368
41RPS6KB21.14259938
42MET1.11715309
43EEF2K1.11196838
44LRRK21.10855474
45MAPK111.08997206
46CDC71.08386233
47PRKAA21.07049098
48PRKD31.04752488
49STK38L1.02688613
50CDK61.01685084
51ILK0.97399866
52MKNK20.96379801
53FER0.96156203
54PASK0.94268587
55FGFR20.92865947
56PDGFRB0.92700628
57PRKG20.89103687
58BMX0.88567375
59STK380.87429988
60EPHA30.85700879
61NEK10.83287580
62FLT30.82742702
63PDPK10.81501778
64ROCK10.80897244
65NTRK30.79959726
66MAP3K80.78553728
67BRD40.78053701
68ERBB20.76965288
69SGK2230.76182452
70SGK4940.76182452
71SMG10.75339917
72MAP3K20.74758490
73CAMK1D0.73235365
74TTK0.71823952
75MARK20.69466101
76FGR0.67429867
77CDK70.65241970
78MAPKAPK30.63145384
79SCYL20.62365722
80ALK0.62146056
81TYRO30.60439118
82AKT20.59369656
83TSSK60.59177173
84CSNK1A1L0.57688603
85ROCK20.57390287
86STK100.56221002
87SGK30.55949675
88CDK40.55570452
89EIF2AK10.55007832
90ERN10.53295131
91NTRK10.52373258
92PRKAA10.52013174
93PAK30.52006068
94SGK10.51305790
95MST1R0.49241728
96PLK30.48844556
97SRC0.47634805
98CDC42BPA0.47613869
99ERBB30.45929448
100PLK20.44375294
101PDK10.43509801
102CLK10.42731683
103RET0.42723883
104CSNK1E0.42563899
105WNK10.40817346
106NEK90.40010934
107NTRK20.39590291
108AKT10.38595979
109MAP2K10.37754579
110KSR10.37305717
111SGK20.36986285
112WEE10.36913841
113CDK80.35624811
114OBSCN0.35140282
115CSNK1G10.34501934
116MAPKAPK50.34457833
117PRKD10.34350755
118CAMK40.33615027
119MAPK10.33613917
120MAP2K30.33449675
121ADRBK10.32972733
122RPS6KB10.32890800
123CHEK10.32750840
124MELK0.32466207
125PNCK0.32305523
126HIPK20.31665324
127CDK140.31624297
128BRSK10.30420332
129LIMK10.29341204
130BCR0.29321689
131RPS6KA40.29209949
132EPHA40.29158746
133CDK20.29021864
134IGF1R0.28438057
135CDK10.28372487
136MAPK90.27750619
137DYRK1B0.26767722
138INSR0.25776709
139TESK10.24913604
140PRKACG0.24779876
141CSNK1D0.24009046
142MATK0.23788744
143MAPK100.23232579
144RPS6KA30.21974483
145TRPM70.21623142
146KSR20.21359616
147MAPK30.19492294
148CDK90.18979730
149GSK3B0.18857806
150MAPK140.17826347

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046105.97475410
2Basal cell carcinoma_Homo sapiens_hsa052173.50807429
3ECM-receptor interaction_Homo sapiens_hsa045123.28354187
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25580099
5Hedgehog signaling pathway_Homo sapiens_hsa043403.07797581
6Hippo signaling pathway_Homo sapiens_hsa043902.87874501
7Protein digestion and absorption_Homo sapiens_hsa049742.72064529
8Adherens junction_Homo sapiens_hsa045202.59761837
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.59564021
10Focal adhesion_Homo sapiens_hsa045102.53641813
11Fat digestion and absorption_Homo sapiens_hsa049752.37804873
12Steroid biosynthesis_Homo sapiens_hsa001002.20405962
13Arginine biosynthesis_Homo sapiens_hsa002202.18835357
14* Proteoglycans in cancer_Homo sapiens_hsa052052.17491607
15PPAR signaling pathway_Homo sapiens_hsa033202.17386299
16Fatty acid biosynthesis_Homo sapiens_hsa000612.15497233
17TGF-beta signaling pathway_Homo sapiens_hsa043502.15374251
18Dilated cardiomyopathy_Homo sapiens_hsa054141.98131652
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.91216976
20Other glycan degradation_Homo sapiens_hsa005111.89803783
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.87699208
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.87067731
23Small cell lung cancer_Homo sapiens_hsa052221.85996523
24Vitamin digestion and absorption_Homo sapiens_hsa049771.85899815
25MicroRNAs in cancer_Homo sapiens_hsa052061.85501029
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.83346772
27Histidine metabolism_Homo sapiens_hsa003401.80601130
28Tight junction_Homo sapiens_hsa045301.80193900
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.75668224
30Wnt signaling pathway_Homo sapiens_hsa043101.72696366
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.72019993
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.71915142
33Cell cycle_Homo sapiens_hsa041101.68398009
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.67221225
35Notch signaling pathway_Homo sapiens_hsa043301.66909668
36Fatty acid degradation_Homo sapiens_hsa000711.66821356
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.66312602
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.65052174
39Bile secretion_Homo sapiens_hsa049761.61537899
40Fatty acid metabolism_Homo sapiens_hsa012121.60651712
41Melanogenesis_Homo sapiens_hsa049161.58708623
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.56622508
43Axon guidance_Homo sapiens_hsa043601.55760243
44Viral myocarditis_Homo sapiens_hsa054161.49385043
45Amoebiasis_Homo sapiens_hsa051461.48689216
46Chronic myeloid leukemia_Homo sapiens_hsa052201.45179797
47Pathways in cancer_Homo sapiens_hsa052001.43213594
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42287596
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41515306
50Lysine degradation_Homo sapiens_hsa003101.38336612
51Phenylalanine metabolism_Homo sapiens_hsa003601.38196101
52PI3K-Akt signaling pathway_Homo sapiens_hsa041511.37209827
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.35848850
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33894474
55Staphylococcus aureus infection_Homo sapiens_hsa051501.32447169
56HTLV-I infection_Homo sapiens_hsa051661.32261831
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28845844
58Prostate cancer_Homo sapiens_hsa052151.28649388
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26790595
60Colorectal cancer_Homo sapiens_hsa052101.23540367
61Starch and sucrose metabolism_Homo sapiens_hsa005001.23510675
62Tyrosine metabolism_Homo sapiens_hsa003501.23185803
63Bladder cancer_Homo sapiens_hsa052191.22053954
64Rap1 signaling pathway_Homo sapiens_hsa040151.21870649
65Prion diseases_Homo sapiens_hsa050201.20173828
66Biosynthesis of amino acids_Homo sapiens_hsa012301.19086812
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17523351
68Arginine and proline metabolism_Homo sapiens_hsa003301.16194504
69Renal cell carcinoma_Homo sapiens_hsa052111.12962459
70Thyroid cancer_Homo sapiens_hsa052161.12138595
71Galactose metabolism_Homo sapiens_hsa000521.11765692
72Fructose and mannose metabolism_Homo sapiens_hsa000511.10923899
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09666722
74ABC transporters_Homo sapiens_hsa020101.09301556
75Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08834228
76Endometrial cancer_Homo sapiens_hsa052131.08253922
77Platelet activation_Homo sapiens_hsa046111.05828739
78Nitrogen metabolism_Homo sapiens_hsa009101.04981931
79Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03381209
80Estrogen signaling pathway_Homo sapiens_hsa049151.03184357
81Central carbon metabolism in cancer_Homo sapiens_hsa052301.01278781
82mRNA surveillance pathway_Homo sapiens_hsa030150.99906787
83Gap junction_Homo sapiens_hsa045400.99674695
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98365639
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98059057
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97732056
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96651183
88Glioma_Homo sapiens_hsa052140.94923821
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92866692
90Spliceosome_Homo sapiens_hsa030400.89998474
91Dorso-ventral axis formation_Homo sapiens_hsa043200.89284999
92Melanoma_Homo sapiens_hsa052180.88639786
93Oocyte meiosis_Homo sapiens_hsa041140.86684387
94RNA transport_Homo sapiens_hsa030130.86017411
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.82954448
96Pancreatic cancer_Homo sapiens_hsa052120.82824160
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82259004
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.81812242
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80038642
100VEGF signaling pathway_Homo sapiens_hsa043700.78939408
101mTOR signaling pathway_Homo sapiens_hsa041500.78012407
102Insulin resistance_Homo sapiens_hsa049310.76524635
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.76392119
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75356901
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74983267
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73889359
107HIF-1 signaling pathway_Homo sapiens_hsa040660.73576075
108Carbon metabolism_Homo sapiens_hsa012000.71543716
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.71261482
110Retinol metabolism_Homo sapiens_hsa008300.69669053
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68529726
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67372155
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66815289
114Non-small cell lung cancer_Homo sapiens_hsa052230.66197123
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66100571
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64985936
117p53 signaling pathway_Homo sapiens_hsa041150.64514408
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63751335
119Thyroid hormone synthesis_Homo sapiens_hsa049180.62815863
120Viral carcinogenesis_Homo sapiens_hsa052030.60722666
121Pyruvate metabolism_Homo sapiens_hsa006200.60699511
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59424626
123Glucagon signaling pathway_Homo sapiens_hsa049220.55651693
124Hepatitis B_Homo sapiens_hsa051610.54835134
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52731897
126FoxO signaling pathway_Homo sapiens_hsa040680.52414247
127Pertussis_Homo sapiens_hsa051330.51469128
128AMPK signaling pathway_Homo sapiens_hsa041520.51017057
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.49772531
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.49112229
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48940736
132Endocytosis_Homo sapiens_hsa041440.48591435
133Peroxisome_Homo sapiens_hsa041460.47884879
134Vitamin B6 metabolism_Homo sapiens_hsa007500.47783301
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46719572
136Butanoate metabolism_Homo sapiens_hsa006500.46708651
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46682562
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46478417
139Renin-angiotensin system_Homo sapiens_hsa046140.45767375
140Chemical carcinogenesis_Homo sapiens_hsa052040.45455603
141Ovarian steroidogenesis_Homo sapiens_hsa049130.45211058
142Glycerolipid metabolism_Homo sapiens_hsa005610.43495537
143GnRH signaling pathway_Homo sapiens_hsa049120.42038023
144Oxytocin signaling pathway_Homo sapiens_hsa049210.41412350
145Ras signaling pathway_Homo sapiens_hsa040140.40662449
146cAMP signaling pathway_Homo sapiens_hsa040240.40624335
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40347287
148Vibrio cholerae infection_Homo sapiens_hsa051100.39569932
149Toxoplasmosis_Homo sapiens_hsa051450.38814464
150Insulin signaling pathway_Homo sapiens_hsa049100.38619536
151Sphingolipid metabolism_Homo sapiens_hsa006000.38433068
152Mineral absorption_Homo sapiens_hsa049780.37927229
153Shigellosis_Homo sapiens_hsa051310.37532072
154MAPK signaling pathway_Homo sapiens_hsa040100.36915951
155Renin secretion_Homo sapiens_hsa049240.35362937
156Choline metabolism in cancer_Homo sapiens_hsa052310.33820781
157N-Glycan biosynthesis_Homo sapiens_hsa005100.32478754
158ErbB signaling pathway_Homo sapiens_hsa040120.28386095
159Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27939995

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