IGF2BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.82969533
2polyketide metabolic process (GO:0030638)6.82969533
3doxorubicin metabolic process (GO:0044598)6.82969533
4protein localization to kinetochore (GO:0034501)6.25005525
5regulation of nuclear cell cycle DNA replication (GO:0033262)5.58280043
6regulation of gene silencing by RNA (GO:0060966)5.58128908
7regulation of posttranscriptional gene silencing (GO:0060147)5.58128908
8regulation of gene silencing by miRNA (GO:0060964)5.58128908
9regulation of telomere maintenance via telomerase (GO:0032210)5.54048762
10nuclear pore complex assembly (GO:0051292)5.49261012
11histone H4-K12 acetylation (GO:0043983)5.23693017
12DNA replication-dependent nucleosome organization (GO:0034723)5.20583993
13DNA replication-dependent nucleosome assembly (GO:0006335)5.20583993
14nuclear pore organization (GO:0006999)5.20198099
15mitotic sister chromatid segregation (GO:0000070)5.15492432
16pre-miRNA processing (GO:0031054)5.04871117
17negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.92920919
18heterochromatin organization (GO:0070828)4.91533616
19histone H4-K5 acetylation (GO:0043981)4.90537441
20histone H4-K8 acetylation (GO:0043982)4.90537441
21protein localization to chromosome, centromeric region (GO:0071459)4.87923603
22somite rostral/caudal axis specification (GO:0032525)4.83014567
23negative regulation of telomerase activity (GO:0051974)4.81741188
24negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.71047750
25negative regulation of epidermis development (GO:0045683)4.68069763
26regulation of mammary gland epithelial cell proliferation (GO:0033599)4.63636608
27maintenance of protein location in nucleus (GO:0051457)4.59810349
28notochord development (GO:0030903)4.58622630
29sister chromatid segregation (GO:0000819)4.47148206
30negative regulation of cell cycle G2/M phase transition (GO:1902750)4.40046306
31DNA replication checkpoint (GO:0000076)4.38898189
32aminoglycoside antibiotic metabolic process (GO:0030647)4.34143786
33chromatin assembly (GO:0031497)4.26602676
34rRNA transcription (GO:0009303)4.25790009
35positive regulation of DNA-dependent DNA replication (GO:2000105)4.19247763
36establishment of integrated proviral latency (GO:0075713)4.16045335
37pore complex assembly (GO:0046931)4.12839964
38DNA strand elongation involved in DNA replication (GO:0006271)4.09647183
39DNA unwinding involved in DNA replication (GO:0006268)4.02318208
40DNA strand elongation (GO:0022616)3.91440599
41cell fate commitment involved in formation of primary germ layer (GO:0060795)3.84556639
42DNA duplex unwinding (GO:0032508)3.80225527
43regulation of translation in response to stress (GO:0043555)3.78386643
44DNA geometric change (GO:0032392)3.77850269
45negative regulation of telomere maintenance (GO:0032205)3.75262194
46protein complex localization (GO:0031503)3.69738284
47formation of translation preinitiation complex (GO:0001731)3.68455233
48DNA topological change (GO:0006265)3.68168116
49L-serine metabolic process (GO:0006563)3.66531975
50negative regulation of epidermal cell differentiation (GO:0045605)3.66101317
51regulation of response to osmotic stress (GO:0047484)3.65765399
52ribosome biogenesis (GO:0042254)3.62610391
53muscle organ morphogenesis (GO:0048644)3.60856252
54chromatin remodeling at centromere (GO:0031055)3.60593831
55histone H4-K16 acetylation (GO:0043984)3.56917273
56paraxial mesoderm development (GO:0048339)3.56177333
57DNA replication initiation (GO:0006270)3.54676712
58primitive streak formation (GO:0090009)3.51181200
59rRNA modification (GO:0000154)3.50557439
60rRNA methylation (GO:0031167)3.50309077
61regulation of MHC class I biosynthetic process (GO:0045343)3.49188612
62positive regulation of SMAD protein import into nucleus (GO:0060391)3.46645765
63mitotic chromosome condensation (GO:0007076)3.45011341
64mitotic sister chromatid cohesion (GO:0007064)3.43216836
65regulation of gene silencing (GO:0060968)3.42117579
66CENP-A containing nucleosome assembly (GO:0034080)3.41484808
67trophectodermal cell differentiation (GO:0001829)3.37818648
68regulation of telomere maintenance (GO:0032204)3.36937452
69mitotic nuclear envelope disassembly (GO:0007077)3.31425090
70telomere maintenance via semi-conservative replication (GO:0032201)3.28364871
71ATP-dependent chromatin remodeling (GO:0043044)3.26873812
72negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.25970394
73nucleosome disassembly (GO:0006337)3.25926143
74protein-DNA complex disassembly (GO:0032986)3.25926143
75DNA replication-independent nucleosome organization (GO:0034724)3.22854146
76DNA replication-independent nucleosome assembly (GO:0006336)3.22854146
77histone arginine methylation (GO:0034969)3.21989119
78negative regulation of gene silencing (GO:0060969)3.20576003
79non-recombinational repair (GO:0000726)3.17086050
80double-strand break repair via nonhomologous end joining (GO:0006303)3.17086050
81branching involved in mammary gland duct morphogenesis (GO:0060444)3.16749746
82regulation of double-strand break repair (GO:2000779)3.15989606
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15052250
84intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.14114984
85cellular protein complex localization (GO:0034629)3.13898987
86regulation of stem cell maintenance (GO:2000036)3.12190338
87cullin deneddylation (GO:0010388)3.11991640
88intestinal epithelial cell development (GO:0060576)3.10910096
89mitotic metaphase plate congression (GO:0007080)3.10392957
90regulation of translational fidelity (GO:0006450)3.09412776
91regulation of hippo signaling (GO:0035330)3.08810066
92regulation of apoptotic process involved in morphogenesis (GO:1902337)3.08632989
93regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.06693059
94membrane disassembly (GO:0030397)3.06415441
95nuclear envelope disassembly (GO:0051081)3.06415441
96convergent extension (GO:0060026)3.03823145
97cell migration involved in gastrulation (GO:0042074)3.01882994
98anterior/posterior axis specification, embryo (GO:0008595)3.01288236
99histone exchange (GO:0043486)3.01179869
100IMP metabolic process (GO:0046040)3.00152102
101regulation of telomerase activity (GO:0051972)2.97982860
102regulation of DNA-dependent DNA replication (GO:0090329)2.97307688
103lung-associated mesenchyme development (GO:0060484)2.96994404
104regulation of cilium movement (GO:0003352)2.96989094
105somatic hypermutation of immunoglobulin genes (GO:0016446)2.95500054
106somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95500054
107DNA conformation change (GO:0071103)2.94879149
108negative regulation of chromosome segregation (GO:0051985)2.94116371
109negative regulation of mRNA processing (GO:0050686)2.93438943
110metaphase plate congression (GO:0051310)2.93289522
111chromatin assembly or disassembly (GO:0006333)2.93086874
112DNA damage response, detection of DNA damage (GO:0042769)2.92859218
113DNA strand renaturation (GO:0000733)2.91393236
114establishment of viral latency (GO:0019043)2.91151733
115nucleobase biosynthetic process (GO:0046112)2.90757704
116folic acid-containing compound biosynthetic process (GO:0009396)2.90235681
117negative regulation of mRNA metabolic process (GO:1903312)2.89590195
118regulation of chromosome segregation (GO:0051983)2.88155194
119purine nucleobase biosynthetic process (GO:0009113)2.88075217
120DNA ligation (GO:0006266)2.87446835
121negative regulation of histone methylation (GO:0031061)2.86381995
122ribonucleoprotein complex biogenesis (GO:0022613)2.85646896
123pseudouridine synthesis (GO:0001522)2.85451737
124protein localization to chromosome (GO:0034502)2.85385254
125anterior/posterior axis specification (GO:0009948)2.85335188
126spindle assembly (GO:0051225)2.85106243
127negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84319622
128negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84319622
129negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84319622
130negative regulation of mitotic sister chromatid separation (GO:2000816)2.84319622
131negative regulation of sister chromatid segregation (GO:0033046)2.84319622
132positive regulation of chromosome segregation (GO:0051984)2.83928217
133spindle checkpoint (GO:0031577)2.83219644
134IMP biosynthetic process (GO:0006188)2.82985469
135regulation of histone H3-K9 methylation (GO:0051570)2.82079247
136kinetochore organization (GO:0051383)2.80736332
137negative regulation of translation, ncRNA-mediated (GO:0040033)2.79175621
138regulation of translation, ncRNA-mediated (GO:0045974)2.79175621
139negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79175621
140mitotic recombination (GO:0006312)2.79035723
141regulation of sister chromatid cohesion (GO:0007063)2.78906055
142regulation of helicase activity (GO:0051095)2.78095607
143negative regulation of RNA splicing (GO:0033119)2.77781645
144mitotic G2/M transition checkpoint (GO:0044818)2.77019120
145planar cell polarity pathway involved in neural tube closure (GO:0090179)2.76952868
146telomere maintenance via recombination (GO:0000722)2.74956380
147mitotic spindle checkpoint (GO:0071174)2.73697644
148nucleoside transmembrane transport (GO:1901642)2.73063381
149protein deneddylation (GO:0000338)2.72197124
150peptidyl-arginine omega-N-methylation (GO:0035247)2.71304586
151regulation of centriole replication (GO:0046599)2.71217796
152intracellular estrogen receptor signaling pathway (GO:0030520)2.71012054
153DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.70665524
154ncRNA catabolic process (GO:0034661)2.69778527
155chromosome condensation (GO:0030261)2.69613799
156regulation of RNA export from nucleus (GO:0046831)2.66880800
157dorsal/ventral axis specification (GO:0009950)2.66630688
158serine family amino acid biosynthetic process (GO:0009070)2.65187555
159embryonic axis specification (GO:0000578)2.65013849
160regulation of centrosome cycle (GO:0046605)2.63884290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.16812963
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.45242619
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.45242619
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.45242619
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.39489249
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33394260
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.11857658
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.06243053
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.02398575
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.01854549
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.95305635
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.91324634
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.89075070
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.84046036
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58905753
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.56859435
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.55693420
18TCF3_18692474_ChIP-Seq_MEFs_Mouse2.51667791
19TCF3_18692474_ChIP-Seq_MESCs_Mouse2.49725638
20* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45704903
21* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.32191164
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21260725
23* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12062169
24NANOG_18555785_ChIP-Seq_MESCs_Mouse2.08245694
25POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.06549218
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04882861
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04070823
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99598846
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98389553
30NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.97965188
31* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96873535
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93948758
33SOX2_18555785_ChIP-Seq_MESCs_Mouse1.93208148
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.88584982
35NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.85941502
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84849451
37* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84682942
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80913656
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79825694
40* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.76132807
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.74685054
42SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.70261726
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68930073
44* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.61765317
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.61583569
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.53094050
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50294205
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49326154
49* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.48690386
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48329109
51NANOG_18692474_ChIP-Seq_MEFs_Mouse1.43987238
52SOX2_18692474_ChIP-Seq_MESCs_Mouse1.43076414
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.42830737
54NANOG_18692474_ChIP-Seq_MESCs_Mouse1.41962690
55SOX2_18692474_ChIP-Seq_MEFs_Mouse1.38009905
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.37939997
57* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.37171348
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36458776
59XRN2_22483619_ChIP-Seq_HELA_Human1.35197305
60AR_21909140_ChIP-Seq_LNCAP_Human1.34821545
61OCT4_18692474_ChIP-Seq_MEFs_Mouse1.34786086
62IRF1_19129219_ChIP-ChIP_H3396_Human1.34323084
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33292580
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30506762
65NANOG_21062744_ChIP-ChIP_HESCs_Human1.30107833
66* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30056063
67CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29607194
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.28223405
69* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26693778
70* MYC_22102868_ChIP-Seq_BL_Human1.26568232
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25324792
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.23949796
73* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23682749
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21425551
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21115242
76ELK1_19687146_ChIP-ChIP_HELA_Human1.20569589
77ETS1_20019798_ChIP-Seq_JURKAT_Human1.18307435
78MYC_18940864_ChIP-ChIP_HL60_Human1.17126803
79* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.16942972
80GATA1_26923725_Chip-Seq_HPCs_Mouse1.16476908
81DCP1A_22483619_ChIP-Seq_HELA_Human1.15280803
82* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12928566
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10624140
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.08778568
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.08390751
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08356575
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08111476
88JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07591860
89FOXP3_21729870_ChIP-Seq_TREG_Human1.06781248
90* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06250204
91* NANOG_16518401_ChIP-PET_MESCs_Mouse1.05736926
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05671421
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05504935
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04162865
95* TTF2_22483619_ChIP-Seq_HELA_Human1.04020480
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.03462841
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02703670
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99567817
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96954992
100KDM5A_27292631_Chip-Seq_BREAST_Human0.96384030
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94924896
102* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93975503
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93946481
104* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91048091
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90947202
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90683858
107E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90062528
108THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89135654
109E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87240821
110KAP1_27257070_Chip-Seq_ESCs_Mouse0.86897406
111GABP_17652178_ChIP-ChIP_JURKAT_Human0.86256254
112GABP_19822575_ChIP-Seq_HepG2_Human0.86055535
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85568490
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85178468
115CIITA_25753668_ChIP-Seq_RAJI_Human0.85071725
116HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84836786
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84798826
118EWS_26573619_Chip-Seq_HEK293_Human0.84771198
119VDR_23849224_ChIP-Seq_CD4+_Human0.82954005
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81860768
121* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81773670
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.81208110
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78264377
124* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75757247
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.72765587

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog3.58722516
2MP0003890_abnormal_embryonic-extraembry3.51122813
3MP0006292_abnormal_olfactory_placode3.49436214
4MP0008057_abnormal_DNA_replication3.47025419
5MP0004264_abnormal_extraembryonic_tissu3.27177845
6MP0000566_synostosis2.83341293
7MP0002254_reproductive_system_inflammat2.81132978
8MP0002653_abnormal_ependyma_morphology2.76130047
9MP0003011_delayed_dark_adaptation2.75418118
10MP0003123_paternal_imprinting2.67178945
11MP0003121_genomic_imprinting2.66246317
12MP0005394_taste/olfaction_phenotype2.62121134
13MP0005499_abnormal_olfactory_system2.62121134
14MP0003122_maternal_imprinting2.54382121
15MP0010030_abnormal_orbit_morphology2.51301598
16MP0003111_abnormal_nucleus_morphology2.50944203
17MP0003077_abnormal_cell_cycle2.45663211
18MP0010094_abnormal_chromosome_stability2.36301166
19MP0010352_gastrointestinal_tract_polyps2.33870547
20MP0003705_abnormal_hypodermis_morpholog2.30409363
21MP0001672_abnormal_embryogenesis/_devel2.25974860
22MP0005380_embryogenesis_phenotype2.25974860
23MP0003693_abnormal_embryo_hatching2.19523692
24MP0003567_abnormal_fetal_cardiomyocyte2.06079112
25MP0004133_heterotaxia2.03932373
26MP0002088_abnormal_embryonic_growth/wei2.02860306
27MP0003984_embryonic_growth_retardation2.02597005
28MP0001293_anophthalmia1.99665901
29* MP0009672_abnormal_birth_weight1.94467531
30MP0004858_abnormal_nervous_system1.92607223
31* MP0000350_abnormal_cell_proliferation1.91845888
32MP0005075_abnormal_melanosome_morpholog1.88674947
33MP0002332_abnormal_exercise_endurance1.87237857
34MP0002085_abnormal_embryonic_tissue1.86760578
35MP0002938_white_spotting1.84656742
36MP0002084_abnormal_developmental_patter1.82963894
37MP0008932_abnormal_embryonic_tissue1.77979047
38MP0001730_embryonic_growth_arrest1.76129871
39MP0003938_abnormal_ear_development1.64060626
40MP0005257_abnormal_intraocular_pressure1.63702660
41* MP0002086_abnormal_extraembryonic_tissu1.62879291
42MP0008789_abnormal_olfactory_epithelium1.58263726
43MP0008007_abnormal_cellular_replicative1.54981613
44MP0000678_abnormal_parathyroid_gland1.53410288
45MP0001697_abnormal_embryo_size1.52947035
46MP0009697_abnormal_copulation1.52657142
47MP0003315_abnormal_perineum_morphology1.49017395
48MP0003283_abnormal_digestive_organ1.47076264
49MP0003718_maternal_effect1.46185735
50MP0000049_abnormal_middle_ear1.45747328
51MP0001849_ear_inflammation1.45673005
52* MP0004197_abnormal_fetal_growth/weight/1.45256146
53MP0003385_abnormal_body_wall1.44849020
54MP0002127_abnormal_cardiovascular_syste1.43127824
55MP0002092_abnormal_eye_morphology1.42769281
56MP0008877_abnormal_DNA_methylation1.38237507
57MP0008058_abnormal_DNA_repair1.38204010
58MP0001299_abnormal_eye_distance/1.36479829
59MP0006035_abnormal_mitochondrial_morpho1.33982984
60MP0002932_abnormal_joint_morphology1.32482957
61MP0002080_prenatal_lethality1.28734325
62* MP0003119_abnormal_digestive_system1.28525132
63MP0001346_abnormal_lacrimal_gland1.26329146
64MP0003937_abnormal_limbs/digits/tail_de1.25834029
65MP0002233_abnormal_nose_morphology1.25558342
66MP0000428_abnormal_craniofacial_morphol1.24535893
67* MP0003942_abnormal_urinary_system1.22919246
68MP0000762_abnormal_tongue_morphology1.16812949
69MP0003935_abnormal_craniofacial_develop1.16531035
70MP0003755_abnormal_palate_morphology1.15494557
71* MP0000432_abnormal_head_morphology1.14328440
72MP0005377_hearing/vestibular/ear_phenot1.13980873
73MP0003878_abnormal_ear_physiology1.13980873
74MP0000313_abnormal_cell_death1.12982485
75MP0002249_abnormal_larynx_morphology1.11890553
76MP0002114_abnormal_axial_skeleton1.11182453
77MP0004272_abnormal_basement_membrane1.10190870
78MP0001286_abnormal_eye_development1.09895921
79MP0005187_abnormal_penis_morphology1.08992256
80MP0005248_abnormal_Harderian_gland1.08570559
81MP0003115_abnormal_respiratory_system1.05629926
82MP0003786_premature_aging1.04375714
83MP0005266_abnormal_metabolism1.04287363
84MP0003787_abnormal_imprinting1.03934478
85MP0000631_abnormal_neuroendocrine_gland1.03789862
86MP0002277_abnormal_respiratory_mucosa1.02687823
87MP0002089_abnormal_postnatal_growth/wei0.98489224
88MP0002234_abnormal_pharynx_morphology0.98300271
89MP0003861_abnormal_nervous_system0.96097677
90MP0002925_abnormal_cardiovascular_devel0.93926058
91MP0002751_abnormal_autonomic_nervous0.92727167
92MP0008961_abnormal_basal_metabolism0.91729646
93MP0002697_abnormal_eye_size0.91206405
94MP0002116_abnormal_craniofacial_bone0.90338694
95MP0000778_abnormal_nervous_system0.88510981
96* MP0002111_abnormal_tail_morphology0.88315256
97MP0003941_abnormal_skin_development0.88292985
98MP0001915_intracranial_hemorrhage0.86908328
99MP0005391_vision/eye_phenotype0.86850654
100MP0004233_abnormal_muscle_weight0.84897219
101MP0002396_abnormal_hematopoietic_system0.84735972
102MP0001529_abnormal_vocalization0.84704144
103MP0005076_abnormal_cell_differentiation0.82805027
104* MP0009703_decreased_birth_body0.82337980
105MP0005623_abnormal_meninges_morphology0.81231325
106MP0009250_abnormal_appendicular_skeleto0.80987531
107MP0005508_abnormal_skeleton_morphology0.79745473
108MP0009053_abnormal_anal_canal0.78103249
109MP0005023_abnormal_wound_healing0.77818088
110MP0002210_abnormal_sex_determination0.77260558
111MP0000534_abnormal_ureter_morphology0.74231245
112MP0001348_abnormal_lacrimal_gland0.72346078
113MP0002152_abnormal_brain_morphology0.71811754
114MP0000579_abnormal_nail_morphology0.71257440
115MP0003806_abnormal_nucleotide_metabolis0.71160442
116MP0000537_abnormal_urethra_morphology0.69919921
117MP0005367_renal/urinary_system_phenotyp0.69617063
118MP0000516_abnormal_urinary_system0.69617063
119* MP0002081_perinatal_lethality0.69161892
120MP0000647_abnormal_sebaceous_gland0.69057869
121MP0000955_abnormal_spinal_cord0.67676090
122MP0002109_abnormal_limb_morphology0.67181416
123MP0001145_abnormal_male_reproductive0.67010272
124MP0000750_abnormal_muscle_regeneration0.66870266
125MP0003136_yellow_coat_color0.66745846
126MP0005384_cellular_phenotype0.66703083
127MP0001661_extended_life_span0.65438565
128MP0010307_abnormal_tumor_latency0.64667792
129MP0002019_abnormal_tumor_incidence0.64202413
130* MP0008770_decreased_survivor_rate0.63210065
131MP0002098_abnormal_vibrissa_morphology0.61106519
132MP0000358_abnormal_cell_content/0.60717959

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.06783638
2Hypochromic microcytic anemia (HP:0004840)5.00207798
3Ependymoma (HP:0002888)4.98852359
4Rib fusion (HP:0000902)4.75533458
5Hepatoblastoma (HP:0002884)4.62452709
6Multiple enchondromatosis (HP:0005701)4.01526006
7Abnormality of the lower motor neuron (HP:0002366)3.93491639
8Rhabdomyosarcoma (HP:0002859)3.92850551
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.89246483
10Neoplasm of striated muscle (HP:0009728)3.84272536
11Nephroblastoma (Wilms tumor) (HP:0002667)3.70757498
12Abnormality of the astrocytes (HP:0100707)3.58387641
13Astrocytoma (HP:0009592)3.58387641
14Chromsome breakage (HP:0040012)3.49175357
15Embryonal renal neoplasm (HP:0011794)3.45553102
16Aplasia/hypoplasia of the humerus (HP:0006507)3.33011795
17Fused cervical vertebrae (HP:0002949)3.28759823
18Rectal fistula (HP:0100590)3.28613512
19Rectovaginal fistula (HP:0000143)3.28613512
20Short humerus (HP:0005792)3.22922962
21Supernumerary spleens (HP:0009799)3.17132887
22Abnormal lung lobation (HP:0002101)3.05438160
23Medulloblastoma (HP:0002885)3.01638838
24Intestinal fistula (HP:0100819)3.01182694
25Abnormality of the salivary glands (HP:0010286)2.95055540
26Shawl scrotum (HP:0000049)2.94693192
27Impulsivity (HP:0100710)2.91182253
28High anterior hairline (HP:0009890)2.82922969
29Glioma (HP:0009733)2.82901176
30Cortical dysplasia (HP:0002539)2.80363519
31Meckel diverticulum (HP:0002245)2.77729881
32Vaginal fistula (HP:0004320)2.74678702
33Colon cancer (HP:0003003)2.74110990
34Trismus (HP:0000211)2.69115661
35Ectopic kidney (HP:0000086)2.68208381
36Broad thumb (HP:0011304)2.65004800
37Septo-optic dysplasia (HP:0100842)2.64668428
38Abnormality of the ileum (HP:0001549)2.62468335
39Increased nuchal translucency (HP:0010880)2.59087944
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.57979747
41Birth length less than 3rd percentile (HP:0003561)2.57038852
42Testicular atrophy (HP:0000029)2.53864350
43Preauricular skin tag (HP:0000384)2.53185237
44Anal stenosis (HP:0002025)2.52750087
45Abnormality of cochlea (HP:0000375)2.51550850
46Reticulocytopenia (HP:0001896)2.49617041
47Bifid tongue (HP:0010297)2.49197377
48Pseudobulbar signs (HP:0002200)2.49065512
49Partial duplication of thumb phalanx (HP:0009944)2.48049403
50Large earlobe (HP:0009748)2.47256036
51Aplasia/Hypoplasia of the sternum (HP:0006714)2.44331187
52Neoplasm of the oral cavity (HP:0100649)2.37755117
53Abnormality of the labia minora (HP:0012880)2.36420141
54Hypoplasia of the fovea (HP:0007750)2.35977184
55Aplasia/Hypoplasia of the fovea (HP:0008060)2.35977184
56Trigonocephaly (HP:0000243)2.34066832
57Vertebral fusion (HP:0002948)2.31929164
58Renal duplication (HP:0000075)2.31282413
59Anophthalmia (HP:0000528)2.30690054
60Skin tags (HP:0010609)2.30083139
61Amyotrophic lateral sclerosis (HP:0007354)2.29762202
62Partial duplication of the phalanx of hand (HP:0009999)2.28911107
63Esophageal atresia (HP:0002032)2.28585012
64Missing ribs (HP:0000921)2.26422700
65Choanal stenosis (HP:0000452)2.25980336
66Supernumerary ribs (HP:0005815)2.24480705
67Selective tooth agenesis (HP:0001592)2.23346539
68Horizontal nystagmus (HP:0000666)2.22375875
69Duodenal stenosis (HP:0100867)2.20345836
70Small intestinal stenosis (HP:0012848)2.20345836
71Anomalous pulmonary venous return (HP:0010772)2.19603654
72Pendular nystagmus (HP:0012043)2.18054982
73Midline defect of the nose (HP:0004122)2.14759375
74Broad phalanges of the hand (HP:0009768)2.11646744
75Short 5th finger (HP:0009237)2.11364103
76Pancreatic islet-cell hyperplasia (HP:0004510)2.10922059
77Supernumerary bones of the axial skeleton (HP:0009144)2.10913116
78Atrophy/Degeneration involving motor neurons (HP:0007373)2.10333149
79Atresia of the external auditory canal (HP:0000413)2.09342287
80Absent radius (HP:0003974)2.09263791
81Triphalangeal thumb (HP:0001199)2.08995141
82Malignant neoplasm of the central nervous system (HP:0100836)2.08656329
83Abdominal situs inversus (HP:0003363)2.06768629
84Abnormality of abdominal situs (HP:0011620)2.06768629
85Myelomeningocele (HP:0002475)2.06577113
86Abnormality of chromosome segregation (HP:0002916)2.06297191
87Preauricular pit (HP:0004467)2.05410692
88Periauricular skin pits (HP:0100277)2.05410692
89Cutaneous syndactyly (HP:0012725)2.05291985
90Hyperinsulinemic hypoglycemia (HP:0000825)2.03903333
91Cutaneous finger syndactyly (HP:0010554)2.02571506
92Abnormality of the phalanges of the hallux (HP:0010057)2.01980751
93Broad finger (HP:0001500)2.01305579
94Abnormal number of incisors (HP:0011064)1.99363387
95Abnormality of the lacrimal duct (HP:0011481)1.98922231
96Spastic diplegia (HP:0001264)1.97367957
97Ragged-red muscle fibers (HP:0003200)1.97217971
98Absent eyebrow (HP:0002223)1.97152149
99Skull defect (HP:0001362)1.96824200
100Irregular epiphyses (HP:0010582)1.96475453
101Abnormality of the distal phalanx of the thumb (HP:0009617)1.95647393
102Hypochromic anemia (HP:0001931)1.95454166
103Premature ovarian failure (HP:0008209)1.95132386
104Abnormality of the duodenum (HP:0002246)1.95010127
105Absent forearm bone (HP:0003953)1.94967174
106Aplasia involving forearm bones (HP:0009822)1.94967174
107Adenoma sebaceum (HP:0009720)1.94621917
108Angiofibromas (HP:0010615)1.94621917
109Hemivertebrae (HP:0002937)1.94425907
110Facial cleft (HP:0002006)1.93413921
111Abnormality of the musculature of the hand (HP:0001421)1.91417284
112Morphological abnormality of the inner ear (HP:0011390)1.90321254
113Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.90255711
114Abnormality of the pulmonary veins (HP:0011718)1.89222999
115Intestinal atresia (HP:0011100)1.86238111
116Diastasis recti (HP:0001540)1.86216357
117Abnormal cartilage morphology (HP:0002763)1.85147241
118Abnormality of the preputium (HP:0100587)1.84818464
119Horseshoe kidney (HP:0000085)1.84682910
120Hypopigmentation of the fundus (HP:0007894)1.84596219
121Breast hypoplasia (HP:0003187)1.83700825
122Tongue fasciculations (HP:0001308)1.82572532
123Broad phalanx (HP:0006009)1.81383135
124Embryonal neoplasm (HP:0002898)1.81118085
125Maternal diabetes (HP:0009800)1.81054256
126Homocystinuria (HP:0002156)1.80618915
127Abnormality of homocysteine metabolism (HP:0010919)1.80618915
128Omphalocele (HP:0001539)1.80453429
129Glossoptosis (HP:0000162)1.79844846
130Abnormality of the septum pellucidum (HP:0007375)1.79020629
131Progressive muscle weakness (HP:0003323)1.78842447
132Overlapping toe (HP:0001845)1.78172354
133Gastrointestinal atresia (HP:0002589)1.77657006
134Abnormality of the aortic arch (HP:0012303)1.77454151
135Gastrointestinal carcinoma (HP:0002672)1.76139296
136Malignant gastrointestinal tract tumors (HP:0006749)1.76139296
137Partial agenesis of the corpus callosum (HP:0001338)1.75376262
138Absent epiphyses (HP:0010577)1.75323561
139Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75323561
140Abnormality of chromosome stability (HP:0003220)1.74706290
141Skin pits (HP:0100276)1.74428841
142Absent septum pellucidum (HP:0001331)1.74006986
143Degeneration of anterior horn cells (HP:0002398)1.73894816
144Abnormality of the anterior horn cell (HP:0006802)1.73894816
145Patellar aplasia (HP:0006443)1.73790619
146Coronal craniosynostosis (HP:0004440)1.73632012
147Duplication of thumb phalanx (HP:0009942)1.73208291
148Sloping forehead (HP:0000340)1.72745215
149Preaxial foot polydactyly (HP:0001841)1.72596503
150Broad long bones (HP:0005622)1.72142357
151Abnormality of the nasolacrimal system (HP:0000614)1.71576897
152Broad palm (HP:0001169)1.70067598
153Vitreoretinal degeneration (HP:0000655)1.67355179
154Abnormality of the carotid arteries (HP:0005344)1.67011110
155Proximal placement of thumb (HP:0009623)1.64288753
156Short middle phalanx of finger (HP:0005819)1.61625680
157Abnormality of the calcaneus (HP:0008364)1.60926757

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.47869129
2GRK53.43093636
3TTK3.33745501
4ERN12.92199013
5GRK62.86391730
6EPHA22.60213105
7CDC72.56328707
8TAF12.49453326
9TYRO32.23635743
10CDK72.14775878
11STK102.13161239
12EEF2K2.10585758
13BUB11.98544778
14CSF1R1.94100431
15WEE11.93580374
16ADRBK21.88491568
17GRK11.87393040
18VRK21.83714405
19SRPK11.80625365
20PLK11.80398689
21MAPK71.77023990
22CHEK21.75344380
23TGFBR21.70549169
24FGFR21.68483174
25MATK1.67803009
26AKT31.66219049
27CAMK1G1.65355133
28CAMK1D1.62234597
29PAK41.59121752
30NEK21.53190051
31SMG11.52410026
32STK241.49653088
33TNIK1.47759992
34GRK71.47706961
35PBK1.39885944
36LATS21.39080980
37MOS1.34420977
38WNK11.33283527
39FGFR11.31417338
40CHEK11.30395742
41MAP3K101.27552561
42RPS6KB21.24132859
43NEK11.20425777
44MKNK11.11956531
45ALK1.10584871
46BRD41.07555647
47TLK11.06428340
48CAMK41.03968122
49AURKA1.01801219
50BRSK11.00033366
51EIF2AK20.99992343
52NME10.96781864
53AURKB0.96557924
54TRIM280.93306072
55PRKG20.93185089
56MTOR0.90768145
57CDK20.90510004
58BCR0.90031471
59FGFR40.88931031
60AKT20.88861403
61CDK40.85826773
62WNK40.83802969
63NTRK10.81297734
64MKNK20.81223683
65MARK20.81172388
66ATM0.78878204
67ATR0.76074135
68STK38L0.73322670
69WNK30.72915542
70PRKCI0.72202210
71CSNK1G10.70624646
72ADRBK10.70414353
73FGFR30.67982833
74ICK0.67575103
75TESK20.66083231
76STK160.64624037
77MAP3K80.63411203
78STK40.62783682
79DYRK30.62184680
80PLK30.62168147
81CSNK1E0.61655100
82PRKDC0.61447605
83CLK10.60489930
84CDK10.59140288
85CDK190.59064825
86NUAK10.58081034
87HIPK20.58025890
88PLK40.56701474
89MAP2K40.56266050
90PASK0.55518497
91MAP3K40.54337110
92TSSK60.53629728
93PAK10.53536952
94ERBB40.50848278
95EIF2AK10.50275222
96TIE10.49756459
97ACVR1B0.49580356
98LATS10.49039337
99RPS6KA40.47013138
100MAP2K60.46586800
101CDK180.45730442
102CDK60.45371954
103EPHB20.44948957
104CSNK1A1L0.42642350
105MELK0.42133745
106KDR0.42062561
107CSNK1G30.41159499
108MAPK140.39849456
109CDK30.38133178
110PTK20.37232308
111PLK20.36966432
112DYRK20.35682524
113PDGFRA0.35529446
114MAPK100.35115366
115GSK3B0.34831074
116BRSK20.34365953
117MAPK10.33394420
118CDK140.33369687
119CSK0.32523744
120BRAF0.32319922
121EPHA40.32136905
122PIM10.31966757
123ERBB20.31711176
124CDK90.31159160
125ZAK0.30306805
126CSNK1D0.30248435
127VRK10.29153656
128MET0.28782860
129BMX0.28726911
130CSNK2A20.27664276
131AKT10.27000940
132SCYL20.23907578
133CSNK2A10.23708171
134STK30.23385986
135PNCK0.22000782
136CDK150.20347289
137MAP3K70.20306343
138CDK11A0.19459646
139INSR0.19064214
140DDR20.19061728

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.78584279
2Vitamin B6 metabolism_Homo sapiens_hsa007503.53300948
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.38199931
4Mismatch repair_Homo sapiens_hsa034303.35919588
5DNA replication_Homo sapiens_hsa030303.34281973
6RNA transport_Homo sapiens_hsa030133.24102139
7One carbon pool by folate_Homo sapiens_hsa006702.79260013
8Spliceosome_Homo sapiens_hsa030402.72705554
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.54477920
10Cell cycle_Homo sapiens_hsa041102.48717878
11Fanconi anemia pathway_Homo sapiens_hsa034602.41254297
12Fructose and mannose metabolism_Homo sapiens_hsa000512.40949932
13mRNA surveillance pathway_Homo sapiens_hsa030152.36285140
14Homologous recombination_Homo sapiens_hsa034402.36206330
15Ribosome_Homo sapiens_hsa030101.99804850
16Base excision repair_Homo sapiens_hsa034101.96436751
17RNA polymerase_Homo sapiens_hsa030201.96233391
18Nucleotide excision repair_Homo sapiens_hsa034201.81659989
19RNA degradation_Homo sapiens_hsa030181.81024931
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.79519952
21Steroid biosynthesis_Homo sapiens_hsa001001.76350781
22Basal cell carcinoma_Homo sapiens_hsa052171.70519183
23Thyroid cancer_Homo sapiens_hsa052161.61711961
24Galactose metabolism_Homo sapiens_hsa000521.59138694
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56840759
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49684503
27Basal transcription factors_Homo sapiens_hsa030221.49441017
28p53 signaling pathway_Homo sapiens_hsa041151.46636146
29Arachidonic acid metabolism_Homo sapiens_hsa005901.46328825
30Hedgehog signaling pathway_Homo sapiens_hsa043401.33663036
31Hippo signaling pathway_Homo sapiens_hsa043901.33312712
32Non-homologous end-joining_Homo sapiens_hsa034501.25255239
33Pyrimidine metabolism_Homo sapiens_hsa002401.22743112
34mTOR signaling pathway_Homo sapiens_hsa041501.21830305
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19505297
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18902641
37Linoleic acid metabolism_Homo sapiens_hsa005911.10858246
38Pyruvate metabolism_Homo sapiens_hsa006201.09404523
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08850093
40Systemic lupus erythematosus_Homo sapiens_hsa053221.04604734
41* MicroRNAs in cancer_Homo sapiens_hsa052060.98684154
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98192965
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97155973
44Notch signaling pathway_Homo sapiens_hsa043300.97049057
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96314737
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95880914
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91857328
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87979357
49Proteasome_Homo sapiens_hsa030500.87883121
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.84165938
51Selenocompound metabolism_Homo sapiens_hsa004500.84028006
52Adherens junction_Homo sapiens_hsa045200.83279936
53Viral carcinogenesis_Homo sapiens_hsa052030.82801803
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81566431
55Pathways in cancer_Homo sapiens_hsa052000.81306847
56Oocyte meiosis_Homo sapiens_hsa041140.80527465
57Biosynthesis of amino acids_Homo sapiens_hsa012300.79739697
58Wnt signaling pathway_Homo sapiens_hsa043100.77282092
59Arginine biosynthesis_Homo sapiens_hsa002200.77009491
60Vitamin digestion and absorption_Homo sapiens_hsa049770.76794730
61Bladder cancer_Homo sapiens_hsa052190.75601867
62Tight junction_Homo sapiens_hsa045300.70530953
63Herpes simplex infection_Homo sapiens_hsa051680.70133215
64Propanoate metabolism_Homo sapiens_hsa006400.67391720
65TGF-beta signaling pathway_Homo sapiens_hsa043500.66044216
66HTLV-I infection_Homo sapiens_hsa051660.65349525
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61672324
68Protein export_Homo sapiens_hsa030600.60380165
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59860210
70Arginine and proline metabolism_Homo sapiens_hsa003300.59247425
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58923966
72Huntingtons disease_Homo sapiens_hsa050160.57955265
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.57348627
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55585520
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55216511
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54629768
77Lysine degradation_Homo sapiens_hsa003100.52898948
78Pentose phosphate pathway_Homo sapiens_hsa000300.52237052
79Fatty acid metabolism_Homo sapiens_hsa012120.51871101
80Proteoglycans in cancer_Homo sapiens_hsa052050.51606234
81N-Glycan biosynthesis_Homo sapiens_hsa005100.49721011
82Small cell lung cancer_Homo sapiens_hsa052220.49518268
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49358654
84Fat digestion and absorption_Homo sapiens_hsa049750.48952139
85Colorectal cancer_Homo sapiens_hsa052100.48696219
86Folate biosynthesis_Homo sapiens_hsa007900.48182590
87Carbon metabolism_Homo sapiens_hsa012000.46159130
88Melanogenesis_Homo sapiens_hsa049160.46058094
89Rap1 signaling pathway_Homo sapiens_hsa040150.43001835
90Axon guidance_Homo sapiens_hsa043600.42511870
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42314961
92Inositol phosphate metabolism_Homo sapiens_hsa005620.42148872
93Purine metabolism_Homo sapiens_hsa002300.42074594
94Sulfur relay system_Homo sapiens_hsa041220.41974578
95Epstein-Barr virus infection_Homo sapiens_hsa051690.41619557
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.40382728
97Alcoholism_Homo sapiens_hsa050340.40072885
98Acute myeloid leukemia_Homo sapiens_hsa052210.40045861
99Fatty acid elongation_Homo sapiens_hsa000620.38241900
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37964556
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37753529
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37477546
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35575695
104Non-small cell lung cancer_Homo sapiens_hsa052230.34728316
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33428221
106Apoptosis_Homo sapiens_hsa042100.32934004
107Metabolic pathways_Homo sapiens_hsa011000.32633159
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.32424858
109Fatty acid biosynthesis_Homo sapiens_hsa000610.30103696
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.29166729
111AMPK signaling pathway_Homo sapiens_hsa041520.29156278
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28045922
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27526725
114Parkinsons disease_Homo sapiens_hsa050120.27175478
115Chronic myeloid leukemia_Homo sapiens_hsa052200.24979731
116ECM-receptor interaction_Homo sapiens_hsa045120.24379931
117Melanoma_Homo sapiens_hsa052180.24205911
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23594084
119Chemical carcinogenesis_Homo sapiens_hsa052040.23240889
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23165918
121Ether lipid metabolism_Homo sapiens_hsa005650.21979488
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21645723
123Choline metabolism in cancer_Homo sapiens_hsa052310.19847991
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18861500
125Endometrial cancer_Homo sapiens_hsa052130.18508170
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.16340118
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15980119
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.14920330
129HIF-1 signaling pathway_Homo sapiens_hsa040660.13516986
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.12797825
131Prostate cancer_Homo sapiens_hsa052150.12227690
132Ovarian steroidogenesis_Homo sapiens_hsa049130.11560946

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