IGF2BP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.43428810
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.25749307
3protein localization to kinetochore (GO:0034501)4.10114758
4mitotic metaphase plate congression (GO:0007080)4.00386789
5heterochromatin organization (GO:0070828)3.91186978
6convergent extension (GO:0060026)3.88412285
7pre-miRNA processing (GO:0031054)3.86301588
8DNA unwinding involved in DNA replication (GO:0006268)3.77733937
9planar cell polarity pathway involved in neural tube closure (GO:0090179)3.75127838
10nuclear pore organization (GO:0006999)3.60527159
11regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.48797460
12metaphase plate congression (GO:0051310)3.48674445
13nuclear pore complex assembly (GO:0051292)3.45171934
14formation of translation preinitiation complex (GO:0001731)3.44404310
15regulation of gene silencing by miRNA (GO:0060964)3.42632967
16regulation of gene silencing by RNA (GO:0060966)3.42632967
17regulation of posttranscriptional gene silencing (GO:0060147)3.42632967
18protein localization to chromosome, centromeric region (GO:0071459)3.42340957
19kinetochore organization (GO:0051383)3.41765353
20notochord development (GO:0030903)3.38056741
21mitotic nuclear envelope disassembly (GO:0007077)3.37287542
22mitotic chromosome condensation (GO:0007076)3.31268827
23regulation of spindle organization (GO:0090224)3.28171223
24DNA replication initiation (GO:0006270)3.26519190
25mitotic sister chromatid segregation (GO:0000070)3.25837787
26DNA replication-dependent nucleosome assembly (GO:0006335)3.23330034
27DNA replication-dependent nucleosome organization (GO:0034723)3.23330034
28regulation of sister chromatid cohesion (GO:0007063)3.22029719
29kinetochore assembly (GO:0051382)3.20985127
30G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.20673905
31regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.15992358
32Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.15748161
33nuclear envelope disassembly (GO:0051081)3.10803377
34membrane disassembly (GO:0030397)3.10803377
35DNA replication checkpoint (GO:0000076)3.06563688
36ribosome assembly (GO:0042255)3.05257516
37body morphogenesis (GO:0010171)3.02630689
38regulation of establishment of planar polarity (GO:0090175)3.02302699
39neuron projection extension involved in neuron projection guidance (GO:1902284)3.02022257
40axon extension involved in axon guidance (GO:0048846)3.02022257
41sister chromatid segregation (GO:0000819)3.01472311
42establishment of chromosome localization (GO:0051303)2.99631150
43DNA strand elongation involved in DNA replication (GO:0006271)2.98018884
44spindle checkpoint (GO:0031577)2.97953289
45establishment or maintenance of monopolar cell polarity (GO:0061339)2.95423533
46establishment of monopolar cell polarity (GO:0061162)2.95423533
47negative regulation of chromosome segregation (GO:0051985)2.95060134
48regulation of mitotic spindle organization (GO:0060236)2.94997370
49regulation of non-canonical Wnt signaling pathway (GO:2000050)2.90518315
50mitotic spindle assembly checkpoint (GO:0007094)2.90114588
51mitotic spindle checkpoint (GO:0071174)2.89973989
52ribosomal small subunit biogenesis (GO:0042274)2.89922699
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.89858448
54establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.89154042
55cochlea morphogenesis (GO:0090103)2.89148554
56spindle assembly checkpoint (GO:0071173)2.89050872
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87679716
58negative regulation of mitotic sister chromatid separation (GO:2000816)2.86944168
59negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86944168
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86944168
61negative regulation of sister chromatid segregation (GO:0033046)2.86944168
62establishment of planar polarity (GO:0001736)2.84681188
63establishment of tissue polarity (GO:0007164)2.84681188
64polarized epithelial cell differentiation (GO:0030859)2.83811552
65DNA strand elongation (GO:0022616)2.83103644
66regulation of stem cell maintenance (GO:2000036)2.82030043
67mitotic sister chromatid cohesion (GO:0007064)2.82024781
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81992342
69regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.81683281
70regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80979339
71maturation of SSU-rRNA (GO:0030490)2.80318318
72protein localization to chromosome (GO:0034502)2.79960831
73regulation of chromosome segregation (GO:0051983)2.79806975
74cell proliferation in forebrain (GO:0021846)2.77184873
75bone trabecula formation (GO:0060346)2.75984192
76negative regulation of DNA repair (GO:0045738)2.74321012
77positive regulation of chromosome segregation (GO:0051984)2.74143853
78chromatin assembly (GO:0031497)2.74109487
79histone H2A monoubiquitination (GO:0035518)2.71403451
80nucleosome disassembly (GO:0006337)2.70674952
81protein-DNA complex disassembly (GO:0032986)2.70674952
82CENP-A containing nucleosome assembly (GO:0034080)2.68978185
83positive regulation of SMAD protein import into nucleus (GO:0060391)2.68363655
84pore complex assembly (GO:0046931)2.68299832
85chromatin remodeling at centromere (GO:0031055)2.66918974
86establishment of apical/basal cell polarity (GO:0035089)2.66615771
87non-canonical Wnt signaling pathway (GO:0035567)2.66368847
88lens fiber cell development (GO:0070307)2.64542701
89regulation of double-strand break repair (GO:2000779)2.63843137
90regulation of sister chromatid segregation (GO:0033045)2.63441816
91regulation of mitotic sister chromatid separation (GO:0010965)2.63441816
92regulation of mitotic sister chromatid segregation (GO:0033047)2.63441816
93mitotic G2/M transition checkpoint (GO:0044818)2.62718781
94regulation of growth hormone secretion (GO:0060123)2.61437226
95chondrocyte proliferation (GO:0035988)2.60488831
96DNA replication-independent nucleosome organization (GO:0034724)2.60008959
97DNA replication-independent nucleosome assembly (GO:0006336)2.60008959
98negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.59616970
99regulation of telomere maintenance via telomerase (GO:0032210)2.58948383
100lateral sprouting from an epithelium (GO:0060601)2.58815546
101attachment of spindle microtubules to kinetochore (GO:0008608)2.58725949
102translational termination (GO:0006415)2.57839124
103camera-type eye morphogenesis (GO:0048593)2.57172754
104DNA duplex unwinding (GO:0032508)2.57118172
105telomere maintenance via semi-conservative replication (GO:0032201)2.57056568
106DNA geometric change (GO:0032392)2.56953825
107chromatin assembly or disassembly (GO:0006333)2.56184659
108regulation of RNA export from nucleus (GO:0046831)2.55090415
109positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.54885704
110positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.54885704
111positive regulation of mitotic sister chromatid separation (GO:1901970)2.54885704
112mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.54372394
113mitotic recombination (GO:0006312)2.52935183
114viral transcription (GO:0019083)2.52877910
115IMP biosynthetic process (GO:0006188)2.52852610
116regulation of SMAD protein import into nucleus (GO:0060390)2.52283980
117regulation of centrosome cycle (GO:0046605)2.51876324
118telomere maintenance via recombination (GO:0000722)2.51025049
119neuronal stem cell maintenance (GO:0097150)2.50359529
120outer ear morphogenesis (GO:0042473)2.49858651
121hippo signaling (GO:0035329)2.48691591
122regulation of cellular senescence (GO:2000772)2.48536519
123embryonic body morphogenesis (GO:0010172)2.48083564
124folic acid-containing compound biosynthetic process (GO:0009396)2.46582608
125establishment or maintenance of bipolar cell polarity (GO:0061245)2.45599299
126establishment or maintenance of apical/basal cell polarity (GO:0035088)2.45599299
127lung-associated mesenchyme development (GO:0060484)2.44996433
128chromosome segregation (GO:0007059)2.44038583
129nucleobase biosynthetic process (GO:0046112)2.43935982
130protein K6-linked ubiquitination (GO:0085020)2.43550968
131neural tube development (GO:0021915)2.42419660
132establishment of integrated proviral latency (GO:0075713)2.42262252
133regulation of double-strand break repair via homologous recombination (GO:0010569)2.42025307
134dorsal/ventral axis specification (GO:0009950)2.41792619
135nuclear envelope organization (GO:0006998)2.41660137
136histone exchange (GO:0043486)2.41201445
137telomere maintenance via telomere lengthening (GO:0010833)2.40850269
138maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.40554844
139L-serine metabolic process (GO:0006563)2.38108706
140regulation of cell fate specification (GO:0042659)2.37040306
141mesodermal cell differentiation (GO:0048333)2.35844021
142protein retention in ER lumen (GO:0006621)2.34227454
143post-anal tail morphogenesis (GO:0036342)2.29709859
144axon extension (GO:0048675)2.28059204
145hemidesmosome assembly (GO:0031581)2.27845788
146ribosomal small subunit assembly (GO:0000028)2.27673029
147substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.27638130
148substrate-independent telencephalic tangential migration (GO:0021826)2.27638130
149renal system development (GO:0072001)2.26246274
150negative regulation of chondrocyte differentiation (GO:0032331)2.25987265
151embryonic foregut morphogenesis (GO:0048617)2.23816725
152DNA damage response, detection of DNA damage (GO:0042769)2.22996197
153nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.22590881
154cell migration in hindbrain (GO:0021535)2.22479423
155RNA localization (GO:0006403)2.19046621
156positive regulation of catenin import into nucleus (GO:0035413)2.19028413
157DNA topological change (GO:0006265)2.18911703
158pattern specification involved in kidney development (GO:0061004)2.18197496
159ribosomal large subunit biogenesis (GO:0042273)2.16837231
160branching involved in salivary gland morphogenesis (GO:0060445)2.15503763
161mesenchymal to epithelial transition (GO:0060231)2.14550828
162regulation of catenin import into nucleus (GO:0035412)2.14500444
163protein complex disassembly (GO:0043241)2.13117061
164neural tube closure (GO:0001843)2.12792786
165positive regulation of neuroblast proliferation (GO:0002052)2.10509755
166tube closure (GO:0060606)2.09764791
167spinal cord development (GO:0021510)2.08731472
168lens morphogenesis in camera-type eye (GO:0002089)2.08525054
169cerebral cortex radially oriented cell migration (GO:0021799)2.08129554
170olfactory bulb development (GO:0021772)2.07183768
171ATP-dependent chromatin remodeling (GO:0043044)2.06492636
172mitotic cytokinesis (GO:0000281)2.06389761
173embryonic retina morphogenesis in camera-type eye (GO:0060059)2.06159420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.93391118
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.87573222
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.07786950
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.72359791
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.61323149
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.17428934
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00963137
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69940060
9AR_21909140_ChIP-Seq_LNCAP_Human2.66449919
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.60981849
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38914769
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.37780076
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.37780076
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.37780076
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34135800
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28962081
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28309025
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.26884327
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26333745
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.22143053
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.09729484
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06890279
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06008700
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.04824965
25TCF3_18692474_ChIP-Seq_MEFs_Mouse2.04627348
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.01410893
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01216260
28XRN2_22483619_ChIP-Seq_HELA_Human2.01128755
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01105505
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.98454887
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.92481779
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.91689020
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.91633900
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90319439
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.88609081
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.87847681
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86244268
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85916172
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.84467558
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.82425108
41TTF2_22483619_ChIP-Seq_HELA_Human1.75204343
42* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73315739
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72031962
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.69738057
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.66273658
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.66012135
47KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.63119705
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61615002
49TCF3_18692474_ChIP-Seq_MESCs_Mouse1.60917165
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59461652
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.55541828
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53853737
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53069060
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51573296
55DCP1A_22483619_ChIP-Seq_HELA_Human1.50598376
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50229121
57* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48412297
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.47677094
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47093080
60SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.45683566
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45041330
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42663467
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40846533
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40653995
65GABP_19822575_ChIP-Seq_HepG2_Human1.40383838
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38903329
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.36633804
68GATA1_26923725_Chip-Seq_HPCs_Mouse1.36585147
69* NANOG_21062744_ChIP-ChIP_HESCs_Human1.35504355
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34514507
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33876978
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33468569
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.33367488
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33070963
75VDR_23849224_ChIP-Seq_CD4+_Human1.32930234
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31925483
77ELK1_19687146_ChIP-ChIP_HELA_Human1.30888752
78ISL1_27105846_Chip-Seq_CPCs_Mouse1.30126311
79MYC_22102868_ChIP-Seq_BL_Human1.29833587
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26899131
81FOXP3_21729870_ChIP-Seq_TREG_Human1.24935195
82ZNF263_19887448_ChIP-Seq_K562_Human1.24902724
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23417905
84EZH2_22144423_ChIP-Seq_EOC_Human1.23252790
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21653925
86FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.21499452
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.21457958
88POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.21139838
89CLOCK_20551151_ChIP-Seq_293T_Human1.20638958
90* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19764322
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18464280
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17272530
93SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17270019
94KDM5A_27292631_Chip-Seq_BREAST_Human1.16873499
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16342737
96NANOG_16153702_ChIP-ChIP_HESCs_Human1.16105022
97CIITA_25753668_ChIP-Seq_RAJI_Human1.14956742
98TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14815915
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.14504083
100TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13820376
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13517515
102* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.12792062
103* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12477210
104* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12099914
105EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11458107
106TFEB_21752829_ChIP-Seq_HELA_Human1.11457189
107EED_16625203_ChIP-ChIP_MESCs_Mouse1.09877527
108ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09646385
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06904761
110ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06574534
111HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06465582
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05001188
113OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02220638
114POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02193485
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01879917
116* TP53_22127205_ChIP-Seq_IMR90_Human1.01348013
117* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01197345
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00872347
119TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99289560
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99251908
121NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99148934
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99111746
123RING1B_27294783_Chip-Seq_NPCs_Mouse0.99032243
124ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98619170
125EZH2_27304074_Chip-Seq_ESCs_Mouse0.98079257
126TP53_16413492_ChIP-PET_HCT116_Human0.97764507
127CBX2_27304074_Chip-Seq_ESCs_Mouse0.96936077
128* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96838161
129YY1_21170310_ChIP-Seq_MESCs_Mouse0.96782895
130EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96513397
131* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96227490
132POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96223839
133SOX17_20123909_ChIP-Seq_XEN_Mouse0.96207030
134TP53_20018659_ChIP-ChIP_R1E_Mouse0.96130268
135* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93553591
136HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91782547
137NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91689893
138SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91359327
139SOX9_26525672_Chip-Seq_HEART_Mouse0.91266670
140* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90424880
141* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90424880
142TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90068292
143CHD1_26751641_Chip-Seq_LNCaP_Human0.88957334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.35190089
2MP0003693_abnormal_embryo_hatching3.19494925
3MP0004957_abnormal_blastocyst_morpholog2.98790030
4MP0003123_paternal_imprinting2.97764319
5MP0003111_abnormal_nucleus_morphology2.74624300
6MP0010094_abnormal_chromosome_stability2.52755287
7MP0003077_abnormal_cell_cycle2.48690679
8MP0003121_genomic_imprinting2.21673945
9MP0008932_abnormal_embryonic_tissue2.13226525
10MP0003705_abnormal_hypodermis_morpholog2.08950412
11MP0008057_abnormal_DNA_replication2.07828185
12MP0009053_abnormal_anal_canal2.05052957
13MP0010352_gastrointestinal_tract_polyps2.04045109
14MP0003941_abnormal_skin_development2.02231159
15MP0003122_maternal_imprinting1.99558308
16MP0003315_abnormal_perineum_morphology1.95882461
17MP0009379_abnormal_foot_pigmentation1.94728086
18MP0003937_abnormal_limbs/digits/tail_de1.94139912
19MP0000537_abnormal_urethra_morphology1.85348913
20MP0008789_abnormal_olfactory_epithelium1.81049155
21MP0003385_abnormal_body_wall1.79830285
22MP0001299_abnormal_eye_distance/1.79277151
23MP0008007_abnormal_cellular_replicative1.78773715
24MP0003567_abnormal_fetal_cardiomyocyte1.75150420
25MP0002085_abnormal_embryonic_tissue1.74909463
26MP0005380_embryogenesis_phenotype1.72805091
27MP0001672_abnormal_embryogenesis/_devel1.72805091
28MP0002084_abnormal_developmental_patter1.71606984
29MP0000778_abnormal_nervous_system1.71441892
30MP0001730_embryonic_growth_arrest1.70766069
31MP0000049_abnormal_middle_ear1.65922570
32MP0004197_abnormal_fetal_growth/weight/1.64367954
33MP0002249_abnormal_larynx_morphology1.63454980
34MP0000350_abnormal_cell_proliferation1.62581795
35MP0008058_abnormal_DNA_repair1.61042167
36MP0005394_taste/olfaction_phenotype1.59901007
37MP0005499_abnormal_olfactory_system1.59901007
38MP0003119_abnormal_digestive_system1.59847724
39MP0001293_anophthalmia1.57835879
40MP0009250_abnormal_appendicular_skeleto1.55733217
41MP0001697_abnormal_embryo_size1.55618356
42MP0006292_abnormal_olfactory_placode1.53177217
43MP0000428_abnormal_craniofacial_morphol1.52267578
44MP0003984_embryonic_growth_retardation1.51465928
45MP0002938_white_spotting1.51367765
46MP0004272_abnormal_basement_membrane1.50629551
47MP0002088_abnormal_embryonic_growth/wei1.50591276
48MP0005076_abnormal_cell_differentiation1.49499365
49MP0003718_maternal_effect1.49276575
50MP0002932_abnormal_joint_morphology1.48489619
51MP0003755_abnormal_palate_morphology1.48476180
52MP0005257_abnormal_intraocular_pressure1.46633174
53MP0003890_abnormal_embryonic-extraembry1.45544043
54MP0005623_abnormal_meninges_morphology1.44150923
55MP0003942_abnormal_urinary_system1.43914366
56MP0002089_abnormal_postnatal_growth/wei1.43773740
57MP0008438_abnormal_cutaneous_collagen1.41369057
58MP0002111_abnormal_tail_morphology1.39925900
59MP0002086_abnormal_extraembryonic_tissu1.39413918
60MP0002653_abnormal_ependyma_morphology1.38165030
61MP0003283_abnormal_digestive_organ1.34661076
62MP0003935_abnormal_craniofacial_develop1.31311869
63MP0000733_abnormal_muscle_development1.28485459
64MP0000432_abnormal_head_morphology1.28402422
65MP0004858_abnormal_nervous_system1.26733844
66MP0002080_prenatal_lethality1.23614704
67MP0003115_abnormal_respiratory_system1.19936392
68MP0009384_cardiac_valve_regurgitation1.19443239
69MP0002282_abnormal_trachea_morphology1.17829743
70MP0005508_abnormal_skeleton_morphology1.16205676
71MP0003878_abnormal_ear_physiology1.13094502
72MP0005377_hearing/vestibular/ear_phenot1.13094502
73MP0000566_synostosis1.12346377
74MP0003938_abnormal_ear_development1.12205622
75MP0001286_abnormal_eye_development1.10676209
76MP0001849_ear_inflammation1.10455088
77MP0002234_abnormal_pharynx_morphology1.10281731
78MP0002116_abnormal_craniofacial_bone1.10193719
79MP0005503_abnormal_tendon_morphology1.09518609
80MP0001529_abnormal_vocalization1.09420450
81MP0002697_abnormal_eye_size1.09298617
82MP0005023_abnormal_wound_healing1.08802795
83MP0004133_heterotaxia1.08370530
84MP0002092_abnormal_eye_morphology1.08252190
85MP0010307_abnormal_tumor_latency1.07867979
86MP0000579_abnormal_nail_morphology1.07266309
87MP0000516_abnormal_urinary_system1.05473298
88MP0005367_renal/urinary_system_phenotyp1.05473298
89MP0002233_abnormal_nose_morphology1.04595195
90MP0000534_abnormal_ureter_morphology1.03137713
91MP0002114_abnormal_axial_skeleton1.02735820
92MP0004264_abnormal_extraembryonic_tissu1.02404644
93MP0005409_darkened_coat_color1.00758533
94MP0002177_abnormal_outer_ear0.99584878
95MP0000490_abnormal_crypts_of0.99418605
96MP0002081_perinatal_lethality0.98227913
97MP0009672_abnormal_birth_weight0.98151307
98MP0009697_abnormal_copulation0.97913561
99MP0005248_abnormal_Harderian_gland0.95141170
100MP0000762_abnormal_tongue_morphology0.94528712
101MP0003136_yellow_coat_color0.94422654
102MP0009703_decreased_birth_body0.94125032
103MP0005197_abnormal_uvea_morphology0.91898923
104MP0000955_abnormal_spinal_cord0.91879367
105MP0002109_abnormal_limb_morphology0.90353088
106MP0001915_intracranial_hemorrhage0.89916103
107MP0002102_abnormal_ear_morphology0.88018799
108MP0003566_abnormal_cell_adhesion0.86888324
109MP0002925_abnormal_cardiovascular_devel0.86794646
110MP0002152_abnormal_brain_morphology0.86679100
111MP0008877_abnormal_DNA_methylation0.84880737
112MP0006054_spinal_hemorrhage0.84352459
113MP0005187_abnormal_penis_morphology0.79745550
114MP0010368_abnormal_lymphatic_system0.79634110
115MP0004185_abnormal_adipocyte_glucose0.79382414
116MP0000313_abnormal_cell_death0.79335540
117MP0009278_abnormal_bone_marrow0.79202434
118MP0003950_abnormal_plasma_membrane0.78901300
119MP0002396_abnormal_hematopoietic_system0.78765915
120MP0003861_abnormal_nervous_system0.78715962
121MP0004233_abnormal_muscle_weight0.78104115
122MP0002184_abnormal_innervation0.77567705
123MP0003786_premature_aging0.76571194
124MP0000631_abnormal_neuroendocrine_gland0.76214163
125MP0005391_vision/eye_phenotype0.75769377
126MP0002210_abnormal_sex_determination0.75201354

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.18173288
2Selective tooth agenesis (HP:0001592)3.15160621
3Short 4th metacarpal (HP:0010044)2.96003463
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.96003463
5Breast hypoplasia (HP:0003187)2.93940920
6Hepatoblastoma (HP:0002884)2.87685224
7Septo-optic dysplasia (HP:0100842)2.80705578
8Neonatal short-limb short stature (HP:0008921)2.80195656
9Patellar aplasia (HP:0006443)2.67823760
10Aplasia/Hypoplasia of the patella (HP:0006498)2.66146911
11Shallow orbits (HP:0000586)2.66048862
12Rib fusion (HP:0000902)2.63501577
13Ankle contracture (HP:0006466)2.56868946
14Partial duplication of thumb phalanx (HP:0009944)2.55850207
15Premature rupture of membranes (HP:0001788)2.55335617
16Renal duplication (HP:0000075)2.52690170
17Absent radius (HP:0003974)2.47003572
18Supernumerary spleens (HP:0009799)2.46537097
19Abnormality of the phalanges of the hallux (HP:0010057)2.45518864
20Atresia of the external auditory canal (HP:0000413)2.44014102
21Abnormal lung lobation (HP:0002101)2.43632359
22Missing ribs (HP:0000921)2.41677615
23Chromsome breakage (HP:0040012)2.35551157
24Colon cancer (HP:0003003)2.35350958
25Nephroblastoma (Wilms tumor) (HP:0002667)2.34766708
26Birth length less than 3rd percentile (HP:0003561)2.34369268
27Spinal cord lesions (HP:0100561)2.32856317
28Syringomyelia (HP:0003396)2.32856317
29Abnormality of the 4th metacarpal (HP:0010012)2.32615300
30Absent forearm bone (HP:0003953)2.32410946
31Aplasia involving forearm bones (HP:0009822)2.32410946
32Medulloblastoma (HP:0002885)2.32358289
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30697562
34Deviation of the thumb (HP:0009603)2.29862982
35Increased nuchal translucency (HP:0010880)2.29781304
36Anophthalmia (HP:0000528)2.28968070
37Proximal placement of thumb (HP:0009623)2.28222803
38Embryonal renal neoplasm (HP:0011794)2.27829913
39Vitreoretinal degeneration (HP:0000655)2.25962619
40Myelomeningocele (HP:0002475)2.25950609
41Facial hemangioma (HP:0000329)2.24951786
4211 pairs of ribs (HP:0000878)2.23382366
43Meckel diverticulum (HP:0002245)2.22414694
44Abnormality of the labia minora (HP:0012880)2.21789833
45Abnormality of the fetal cardiovascular system (HP:0010948)2.20962443
46Abnormal umbilical cord blood vessels (HP:0011403)2.20962443
47Single umbilical artery (HP:0001195)2.20962443
48Aplasia/hypoplasia of the humerus (HP:0006507)2.20607779
49Abnormal number of incisors (HP:0011064)2.19892995
50Rhabdomyosarcoma (HP:0002859)2.19711084
51Abnormality of dentin (HP:0010299)2.19527052
52Broad palm (HP:0001169)2.15419949
53Abnormality of the ileum (HP:0001549)2.13491080
54Cortical dysplasia (HP:0002539)2.12741151
55Broad thumb (HP:0011304)2.11547360
56Short middle phalanx of the 5th finger (HP:0004220)2.07209545
57Duplication of thumb phalanx (HP:0009942)2.06868791
58Short humerus (HP:0005792)2.04787246
59Ectopic kidney (HP:0000086)2.04777332
60Broad toe (HP:0001837)2.02984989
61Trigonocephaly (HP:0000243)2.01755914
62Shawl scrotum (HP:0000049)2.00652019
63Hypoplastic pelvis (HP:0008839)1.99616637
64Cutaneous finger syndactyly (HP:0010554)1.99549116
65Cutaneous syndactyly (HP:0012725)1.98124342
66Fused cervical vertebrae (HP:0002949)1.97698853
67Aplasia/Hypoplasia of the sternum (HP:0006714)1.96437044
68Short 5th finger (HP:0009237)1.95883833
69Breech presentation (HP:0001623)1.95374031
70Abnormality of the aortic arch (HP:0012303)1.95084635
71Ependymoma (HP:0002888)1.94201505
72Trismus (HP:0000211)1.93531872
73High anterior hairline (HP:0009890)1.92903725
74Wrist flexion contracture (HP:0001239)1.91508887
75Supernumerary ribs (HP:0005815)1.91265271
76Carpal synostosis (HP:0009702)1.90895738
77Abdominal situs inversus (HP:0003363)1.88825141
78Abnormality of abdominal situs (HP:0011620)1.88825141
79Absent epiphyses (HP:0010577)1.88093476
80Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88093476
81Neoplasm of striated muscle (HP:0009728)1.87262578
82Arnold-Chiari malformation (HP:0002308)1.87196124
83Disproportionate tall stature (HP:0001519)1.87020233
84Synostosis of carpal bones (HP:0005048)1.86954151
85Abnormality of the distal phalanx of the thumb (HP:0009617)1.86787482
86Morphological abnormality of the middle ear (HP:0008609)1.85891816
87Broad phalanx (HP:0006009)1.84048231
88Bilateral microphthalmos (HP:0007633)1.83501692
89Partial duplication of the phalanx of hand (HP:0009999)1.83456344
90Neoplasm of the pancreas (HP:0002894)1.83406828
91Vertebral arch anomaly (HP:0008438)1.81948765
92Preaxial foot polydactyly (HP:0001841)1.81198495
93Coronal craniosynostosis (HP:0004440)1.80597341
94Supernumerary bones of the axial skeleton (HP:0009144)1.79926322
95Small intestinal stenosis (HP:0012848)1.79809059
96Duodenal stenosis (HP:0100867)1.79809059
97Microglossia (HP:0000171)1.79545378
98Broad phalanges of the hand (HP:0009768)1.78386605
99Impulsivity (HP:0100710)1.78291879
100Atrophic scars (HP:0001075)1.78109402
101Hemivertebrae (HP:0002937)1.77945893
102Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.77889297
103Wide anterior fontanel (HP:0000260)1.77224756
104Flat acetabular roof (HP:0003180)1.76820475
105Soft skin (HP:0000977)1.76671322
106Abnormality of the calcaneus (HP:0008364)1.76509416
107Aplasia/Hypoplasia of the uvula (HP:0010293)1.74169675
108Volvulus (HP:0002580)1.73887243
109Facial cleft (HP:0002006)1.73299794
110Abnormality of the umbilical cord (HP:0010881)1.73216295
111Midline defect of the nose (HP:0004122)1.72902068
112Stenosis of the external auditory canal (HP:0000402)1.72757194
113Omphalocele (HP:0001539)1.72386284
114Oligodactyly (HP:0012165)1.72023881
115Short thumb (HP:0009778)1.71966577
116Bifid tongue (HP:0010297)1.71765079
117Irregular epiphyses (HP:0010582)1.71138929
118Vertebral fusion (HP:0002948)1.70546563
119Natal tooth (HP:0000695)1.70424276
120Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.70277901
121Reticulocytopenia (HP:0001896)1.69946287
122Esophageal atresia (HP:0002032)1.69090903
123Diastasis recti (HP:0001540)1.69017577
124Abnormality of the parietal bone (HP:0002696)1.68629622
125Vertebral clefting (HP:0008428)1.68627488
126Abnormality of the lacrimal duct (HP:0011481)1.67631426
127Triphalangeal thumb (HP:0001199)1.67460127
128Maternal diabetes (HP:0009800)1.66596530
129Tracheoesophageal fistula (HP:0002575)1.65202246
130Pterygium (HP:0001059)1.65131225
131Capillary hemangiomas (HP:0005306)1.65007744
132Aplasia/Hypoplasia of the breasts (HP:0010311)1.64079788
133Mesomelia (HP:0003027)1.64079710
134Slender long bone (HP:0003100)1.63854866
135Broad finger (HP:0001500)1.63694687
136Preauricular skin tag (HP:0000384)1.63479995
137Gastrointestinal carcinoma (HP:0002672)1.62760621
138Malignant gastrointestinal tract tumors (HP:0006749)1.62760621
139Broad long bones (HP:0005622)1.62417847
140Short phalanx of the thumb (HP:0009660)1.62233851
141Vertebral hypoplasia (HP:0008417)1.61897061
142Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.61897061
143Ulnar bowing (HP:0003031)1.61650117
144Broad metatarsal (HP:0001783)1.61497632
145Epiphyseal dysplasia (HP:0002656)1.60086352
146Aplasia involving bones of the upper limbs (HP:0009823)1.60086285
147Aplasia of the phalanges of the hand (HP:0009802)1.60086285
148Aplasia involving bones of the extremities (HP:0009825)1.60086285
149Limited elbow extension (HP:0001377)1.59894694
150Broad alveolar ridges (HP:0000187)1.59821829
151Abnormality of the antihelix (HP:0009738)1.59413237
152Abnormality of the pubic bones (HP:0003172)1.58700514
153Absent septum pellucidum (HP:0001331)1.57858388
154Abnormality of the middle phalanges of the toes (HP:0010183)1.57410729
155Breast aplasia (HP:0100783)1.56478804
156Choanal stenosis (HP:0000452)1.56039501
157Abnormality of the acetabulum (HP:0003170)1.55149363
158Abnormality of cells of the erythroid lineage (HP:0012130)1.54180415
159Hypoplasia of the capital femoral epiphysis (HP:0003090)1.53407285
160Rhizomelia (HP:0008905)1.52419523
161Abnormality of the nasal septum (HP:0000419)1.51769317
162Bladder diverticulum (HP:0000015)1.51599341
163Thin ribs (HP:0000883)1.51377823
164Long palpebral fissure (HP:0000637)1.51124999
165Heterotopia (HP:0002282)1.50034605
166Optic nerve hypoplasia (HP:0000609)1.48949519
167Deep palmar crease (HP:0006191)1.47257422
168Skull defect (HP:0001362)1.46243027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.45697328
2TTK3.17705762
3WEE13.11502698
4BUB13.09425314
5MKNK12.98095846
6PNCK2.86047782
7CDK122.85064087
8NEK22.72602863
9LATS22.59749397
10LATS12.49610252
11MKNK22.41722443
12PLK42.41151635
13WNK42.25969290
14EPHA22.21959090
15TNIK2.16848754
16SRPK12.16629506
17CAMK1G2.07935671
18NTRK12.06141284
19PLK12.01534747
20CDK71.97841791
21DDR21.79547545
22STK38L1.71486445
23PASK1.71201485
24CHEK21.67286541
25FLT31.67214406
26MAP3K81.56512880
27AURKB1.54731325
28MAP3K101.54591223
29CAMK1D1.53442181
30STK31.52338172
31STK101.48804604
32RPS6KA41.48369096
33BCR1.46186937
34CDK41.44553591
35EPHB21.43467130
36BRSK21.42990666
37EIF2AK11.41742732
38WNK11.41721459
39PAK41.37648952
40PDGFRA1.32644490
41PLK31.32482286
42TSSK61.28740295
43BRD41.26084522
44RPS6KB21.25842279
45TGFBR11.25084566
46ATR1.24657452
47TESK21.24075892
48CASK1.22393890
49ACVR1B1.21150420
50DYRK31.20620470
51NEK11.19641287
52PKN21.19417741
53CHEK11.15998695
54MARK11.14179868
55MTOR1.09604213
56AURKA1.09395647
57CDK191.07087175
58CDK61.01448192
59PAK10.97122787
60CDK80.97018322
61DYRK1B0.96543765
62MELK0.93058641
63PAK20.93028287
64MOS0.92480760
65TAF10.92031654
66TLK10.89444082
67EEF2K0.87341490
68CDK20.87312554
69MAP3K90.87243038
70ATM0.87063615
71TRIB30.86843164
72ICK0.86534538
73EIF2AK30.85575298
74STK160.85052322
75NTRK20.84239311
76NME20.83276132
77MAP2K70.80607155
78BMX0.80449748
79DMPK0.78950888
80BRAF0.77681832
81KSR10.73858673
82MAP3K40.73637587
83FGFR10.71538421
84MET0.70415225
85PBK0.69445552
86PLK20.69210967
87STK390.69147959
88NLK0.68792833
89CDK10.68172775
90FGFR20.67823352
91TAOK20.67606384
92STK40.67443953
93MST1R0.66426421
94AKT30.65077592
95STK240.62311219
96SMG10.61663285
97PDGFRB0.60131020
98PIM10.59427113
99LRRK20.58559225
100PRKCI0.58347539
101DYRK20.56692934
102MARK20.56662464
103PIM20.56146972
104CDK11A0.55986579
105CSNK1E0.55286918
106CSNK2A10.54742133
107PTK20.54306883
108ERBB40.54099123
109CSNK1G10.52298190
110CDK150.51358268
111CSNK2A20.50751821
112ALK0.49841390
113CDK180.49008993
114EIF2AK20.47509238
115AKT20.47063356
116CDK140.46510165
117ILK0.44972437
118RPS6KA20.44892887
119YES10.44561748
120FGFR40.43546069
121TYRO30.42632335
122VRK20.42435580
123TTN0.41501814
124NUAK10.41295933
125SGK2230.41198575
126SGK4940.41198575
127MAP2K20.40308143
128CDK90.40044322
129AKT10.39403965
130CSNK1A1L0.36794467
131BRSK10.36751580
132MAP3K60.36282450
133MAPK10.36172587
134PRKD20.35126740
135ERBB20.34942542
136PRKDC0.34371635
137PTK60.33700868
138CSNK1D0.32813382

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.60976657
2Mismatch repair_Homo sapiens_hsa034303.19842133
3RNA transport_Homo sapiens_hsa030133.14295328
4Cell cycle_Homo sapiens_hsa041103.07364716
5Spliceosome_Homo sapiens_hsa030403.07188864
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06262892
7Base excision repair_Homo sapiens_hsa034102.60654324
8Homologous recombination_Homo sapiens_hsa034402.53649702
9Steroid biosynthesis_Homo sapiens_hsa001002.42510884
10RNA polymerase_Homo sapiens_hsa030202.38895392
11Ribosome_Homo sapiens_hsa030102.30631592
12Nucleotide excision repair_Homo sapiens_hsa034202.30236540
13One carbon pool by folate_Homo sapiens_hsa006702.15324257
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.11079587
15Basal cell carcinoma_Homo sapiens_hsa052172.06763367
16Fanconi anemia pathway_Homo sapiens_hsa034602.03307133
17mRNA surveillance pathway_Homo sapiens_hsa030151.99194878
18Basal transcription factors_Homo sapiens_hsa030221.92780182
19p53 signaling pathway_Homo sapiens_hsa041151.92131786
20Proteasome_Homo sapiens_hsa030501.86275607
21RNA degradation_Homo sapiens_hsa030181.82297530
22Hippo signaling pathway_Homo sapiens_hsa043901.81953676
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80576119
24Hedgehog signaling pathway_Homo sapiens_hsa043401.72451725
25Non-homologous end-joining_Homo sapiens_hsa034501.70008678
26Pyrimidine metabolism_Homo sapiens_hsa002401.64439843
27MicroRNAs in cancer_Homo sapiens_hsa052061.58132768
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50069524
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.49088197
30Adherens junction_Homo sapiens_hsa045201.48757126
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44648555
32TGF-beta signaling pathway_Homo sapiens_hsa043501.42936913
33Small cell lung cancer_Homo sapiens_hsa052221.21539466
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14995677
35HTLV-I infection_Homo sapiens_hsa051661.14929499
36Notch signaling pathway_Homo sapiens_hsa043301.10263161
37Thyroid cancer_Homo sapiens_hsa052161.10259439
38Bladder cancer_Homo sapiens_hsa052191.07271616
39Epstein-Barr virus infection_Homo sapiens_hsa051691.05201564
40Viral carcinogenesis_Homo sapiens_hsa052031.04460975
41Oocyte meiosis_Homo sapiens_hsa041141.04071263
42Wnt signaling pathway_Homo sapiens_hsa043101.03046476
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99821566
44Proteoglycans in cancer_Homo sapiens_hsa052050.98755415
45Herpes simplex infection_Homo sapiens_hsa051680.96342202
46Tight junction_Homo sapiens_hsa045300.92517233
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91427732
48ECM-receptor interaction_Homo sapiens_hsa045120.90873857
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89399773
50ErbB signaling pathway_Homo sapiens_hsa040120.89385889
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89139278
52Pathways in cancer_Homo sapiens_hsa052000.88772399
53Prostate cancer_Homo sapiens_hsa052150.87189254
54Colorectal cancer_Homo sapiens_hsa052100.86041867
55Biosynthesis of amino acids_Homo sapiens_hsa012300.83892893
56Chronic myeloid leukemia_Homo sapiens_hsa052200.83289676
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82474262
58Dilated cardiomyopathy_Homo sapiens_hsa054140.81321803
59Purine metabolism_Homo sapiens_hsa002300.79976779
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78916968
61Fat digestion and absorption_Homo sapiens_hsa049750.77962419
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77634469
63Melanoma_Homo sapiens_hsa052180.77402816
64Gap junction_Homo sapiens_hsa045400.76994232
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76576509
66Focal adhesion_Homo sapiens_hsa045100.72754553
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70976936
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65628768
69Thyroid hormone synthesis_Homo sapiens_hsa049180.65101928
70Shigellosis_Homo sapiens_hsa051310.64241717
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.62734354
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62397575
73Hepatitis B_Homo sapiens_hsa051610.61020253
74Fatty acid biosynthesis_Homo sapiens_hsa000610.60492985
75Pancreatic cancer_Homo sapiens_hsa052120.57423627
76Viral myocarditis_Homo sapiens_hsa054160.55005205
77Legionellosis_Homo sapiens_hsa051340.54643720
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52923354
79Systemic lupus erythematosus_Homo sapiens_hsa053220.51952584
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51258793
81Sulfur relay system_Homo sapiens_hsa041220.50798751
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50375576
83mTOR signaling pathway_Homo sapiens_hsa041500.49266620
84Glioma_Homo sapiens_hsa052140.48778352
85Apoptosis_Homo sapiens_hsa042100.48769335
86Antigen processing and presentation_Homo sapiens_hsa046120.48224686
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48173980
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47867991
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.46934864
90AMPK signaling pathway_Homo sapiens_hsa041520.46618346
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.46433335
92Endometrial cancer_Homo sapiens_hsa052130.45430288
93HIF-1 signaling pathway_Homo sapiens_hsa040660.45250777
94Vitamin digestion and absorption_Homo sapiens_hsa049770.45017100
95Protein export_Homo sapiens_hsa030600.43907671
96Ras signaling pathway_Homo sapiens_hsa040140.41720033
97Huntingtons disease_Homo sapiens_hsa050160.40629608
98Cardiac muscle contraction_Homo sapiens_hsa042600.38653543
99Pyruvate metabolism_Homo sapiens_hsa006200.37836491
100Choline metabolism in cancer_Homo sapiens_hsa052310.37203705
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36907570
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36731395
103Rap1 signaling pathway_Homo sapiens_hsa040150.34821123
104FoxO signaling pathway_Homo sapiens_hsa040680.34753856
105Vitamin B6 metabolism_Homo sapiens_hsa007500.33791588
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33320964
107Insulin signaling pathway_Homo sapiens_hsa049100.33010777
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.32892786
109Renal cell carcinoma_Homo sapiens_hsa052110.31735064
110Melanogenesis_Homo sapiens_hsa049160.31023054
111N-Glycan biosynthesis_Homo sapiens_hsa005100.30770856
112Amoebiasis_Homo sapiens_hsa051460.30766284
113TNF signaling pathway_Homo sapiens_hsa046680.30201515
114Arachidonic acid metabolism_Homo sapiens_hsa005900.29600113
115Folate biosynthesis_Homo sapiens_hsa007900.29536277
116Influenza A_Homo sapiens_hsa051640.27822376
117Acute myeloid leukemia_Homo sapiens_hsa052210.27144870
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27132472
119Selenocompound metabolism_Homo sapiens_hsa004500.26973187
120Protein digestion and absorption_Homo sapiens_hsa049740.24813841
121Galactose metabolism_Homo sapiens_hsa000520.24733214
122Lysine degradation_Homo sapiens_hsa003100.23972195
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22957912
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22647686
125Measles_Homo sapiens_hsa051620.21315807
126Malaria_Homo sapiens_hsa051440.21152748
127Axon guidance_Homo sapiens_hsa043600.20985529
128Non-small cell lung cancer_Homo sapiens_hsa052230.20086575
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19799321
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19348834

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