IGF2BP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.12795829
2establishment of integrated proviral latency (GO:0075713)4.82210032
3DNA replication initiation (GO:0006270)4.28653962
4DNA replication checkpoint (GO:0000076)4.18510063
5DNA strand elongation involved in DNA replication (GO:0006271)4.16570249
6telomere maintenance via semi-conservative replication (GO:0032201)4.10691060
7regulation of histone H3-K9 methylation (GO:0051570)4.05510094
8DNA strand elongation (GO:0022616)3.98340868
9kinetochore organization (GO:0051383)3.97580231
10ribosomal small subunit assembly (GO:0000028)3.93557237
11mitotic metaphase plate congression (GO:0007080)3.93001873
12pore complex assembly (GO:0046931)3.92728181
13kinetochore assembly (GO:0051382)3.91612366
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.85114285
15mitotic chromosome condensation (GO:0007076)3.80182726
16telomere maintenance via recombination (GO:0000722)3.70184531
17protein localization to kinetochore (GO:0034501)3.67428674
18DNA unwinding involved in DNA replication (GO:0006268)3.66953854
19mitotic recombination (GO:0006312)3.60299709
20regulation of nuclear cell cycle DNA replication (GO:0033262)3.59833117
21L-serine metabolic process (GO:0006563)3.55797921
22CENP-A containing nucleosome assembly (GO:0034080)3.55123218
23chromatin remodeling at centromere (GO:0031055)3.53227715
24protein localization to chromosome, centromeric region (GO:0071459)3.52817060
25mitotic sister chromatid cohesion (GO:0007064)3.52424694
26regulation of double-strand break repair via homologous recombination (GO:0010569)3.52254991
27negative regulation of histone methylation (GO:0031061)3.51279270
28metaphase plate congression (GO:0051310)3.44054215
29establishment of viral latency (GO:0019043)3.40865615
30maturation of SSU-rRNA (GO:0030490)3.39274696
31paraxial mesoderm development (GO:0048339)3.36658969
32proteasome assembly (GO:0043248)3.35942472
33positive regulation of SMAD protein import into nucleus (GO:0060391)3.34716620
34spliceosomal snRNP assembly (GO:0000387)3.33564745
35mitotic sister chromatid segregation (GO:0000070)3.32278922
36regulation of chromosome segregation (GO:0051983)3.31374909
37telomere maintenance via telomere lengthening (GO:0010833)3.30974462
38protein complex localization (GO:0031503)3.30346874
39notochord development (GO:0030903)3.25001106
40positive regulation of chromosome segregation (GO:0051984)3.24195898
41regulation of helicase activity (GO:0051095)3.23193050
42DNA replication-dependent nucleosome assembly (GO:0006335)3.22018729
43DNA replication-dependent nucleosome organization (GO:0034723)3.22018729
44ribosomal large subunit biogenesis (GO:0042273)3.21775520
45negative regulation of DNA repair (GO:0045738)3.20690265
46peptidyl-arginine omega-N-methylation (GO:0035247)3.19917502
47regulation of centriole replication (GO:0046599)3.15773869
48meiotic chromosome segregation (GO:0045132)3.15301606
49chromatin assembly (GO:0031497)3.14987747
50DNA duplex unwinding (GO:0032508)3.13781685
51DNA replication-independent nucleosome assembly (GO:0006336)3.10934916
52DNA replication-independent nucleosome organization (GO:0034724)3.10934916
53regulation of mitotic metaphase/anaphase transition (GO:0030071)3.10693152
54regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.10693152
55DNA damage response, detection of DNA damage (GO:0042769)3.09514181
56DNA topological change (GO:0006265)3.08810628
57viral transcription (GO:0019083)3.08791692
58regulation of mitotic sister chromatid separation (GO:0010965)3.07912958
59regulation of mitotic sister chromatid segregation (GO:0033047)3.07912958
60regulation of sister chromatid segregation (GO:0033045)3.07912958
61DNA geometric change (GO:0032392)3.07363830
62ribosomal small subunit biogenesis (GO:0042274)3.05390902
63histone arginine methylation (GO:0034969)3.04961469
64histone exchange (GO:0043486)3.04137360
65ribonucleoprotein complex biogenesis (GO:0022613)3.04025103
66DNA deamination (GO:0045006)3.03934984
67IMP metabolic process (GO:0046040)3.03217851
68chromatin assembly or disassembly (GO:0006333)3.02295098
69non-recombinational repair (GO:0000726)3.01218004
70double-strand break repair via nonhomologous end joining (GO:0006303)3.01218004
71nucleotide-excision repair, DNA gap filling (GO:0006297)2.99931694
72regulation of centrosome cycle (GO:0046605)2.99873045
73translational termination (GO:0006415)2.99334919
74nuclear pore organization (GO:0006999)2.99156272
75nuclear envelope disassembly (GO:0051081)2.98985132
76membrane disassembly (GO:0030397)2.98985132
77DNA ligation (GO:0006266)2.98501610
78intra-S DNA damage checkpoint (GO:0031573)2.98277254
79establishment of chromosome localization (GO:0051303)2.98263492
80ribosome biogenesis (GO:0042254)2.97244271
81formation of translation preinitiation complex (GO:0001731)2.97057887
82regulation of gene silencing (GO:0060968)2.96595824
83regulation of gene silencing by RNA (GO:0060966)2.96565020
84regulation of posttranscriptional gene silencing (GO:0060147)2.96565020
85regulation of gene silencing by miRNA (GO:0060964)2.96565020
86regulation of telomere maintenance via telomerase (GO:0032210)2.96223692
87regulation of double-strand break repair (GO:2000779)2.95150778
88positive regulation of cell cycle G2/M phase transition (GO:1902751)2.94164982
89positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.94164982
90viral mRNA export from host cell nucleus (GO:0046784)2.93390132
91regulation of sister chromatid cohesion (GO:0007063)2.92251475
92transcription-coupled nucleotide-excision repair (GO:0006283)2.92140646
93regulation of cell fate specification (GO:0042659)2.91548757
94regulation of translational fidelity (GO:0006450)2.90171540
95DNA strand renaturation (GO:0000733)2.90085559
96nuclear pore complex assembly (GO:0051292)2.90063079
97convergent extension (GO:0060026)2.89317708
98somatic diversification of immune receptors via somatic mutation (GO:0002566)2.89198950
99somatic hypermutation of immunoglobulin genes (GO:0016446)2.89198950
100regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88924544
101sister chromatid segregation (GO:0000819)2.88302879
102pseudouridine synthesis (GO:0001522)2.88088375
103spliceosomal complex assembly (GO:0000245)2.86511341
104mitotic G2/M transition checkpoint (GO:0044818)2.84568265
105purine nucleobase biosynthetic process (GO:0009113)2.84075007
106chromosome condensation (GO:0030261)2.83292502
107lung-associated mesenchyme development (GO:0060484)2.82944783
108spindle checkpoint (GO:0031577)2.82482816
109ATP-dependent chromatin remodeling (GO:0043044)2.80785985
110regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.79430232
111translational initiation (GO:0006413)2.79238437
112regulation of RNA export from nucleus (GO:0046831)2.79118967
113regulation of mitotic spindle checkpoint (GO:1903504)2.78062299
114regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.78062299
115regulation of spindle organization (GO:0090224)2.77399983
116attachment of spindle microtubules to kinetochore (GO:0008608)2.76646733
117peptidyl-arginine methylation (GO:0018216)2.75208069
118peptidyl-arginine N-methylation (GO:0035246)2.75208069
119ribosome assembly (GO:0042255)2.74908751
120mitotic nuclear envelope disassembly (GO:0007077)2.74821593
121cell fate commitment involved in formation of primary germ layer (GO:0060795)2.73779229
122RNA splicing, via transesterification reactions (GO:0000375)2.71245857
123positive regulation of DNA-dependent DNA replication (GO:2000105)2.70513956
124negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.69712290
125negative regulation of sister chromatid segregation (GO:0033046)2.69712290
126negative regulation of mitotic sister chromatid separation (GO:2000816)2.69712290
127negative regulation of mitotic sister chromatid segregation (GO:0033048)2.69712290
128rRNA processing (GO:0006364)2.69699474
129negative regulation of chromosome segregation (GO:0051985)2.69328003
130maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.68408566
131transcription elongation from RNA polymerase III promoter (GO:0006385)2.68009791
132termination of RNA polymerase III transcription (GO:0006386)2.68009791
133DNA replication (GO:0006260)2.67258557
134heterochromatin organization (GO:0070828)2.67100955
135maturation of 5.8S rRNA (GO:0000460)2.67043519
136mitotic spindle checkpoint (GO:0071174)2.66062406
137regulation of stem cell maintenance (GO:2000036)2.65869037
138spindle assembly checkpoint (GO:0071173)2.64816382
139RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.64524428
140mRNA splicing, via spliceosome (GO:0000398)2.64524428
141negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.64314602
142nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.64173125
143translational elongation (GO:0006414)2.63488729
144rRNA modification (GO:0000154)2.62942314
145protein localization to chromosome (GO:0034502)2.62851229
146facial nerve structural organization (GO:0021612)2.62179043
147IMP biosynthetic process (GO:0006188)2.62008785
148rRNA metabolic process (GO:0016072)2.60760498
149termination of RNA polymerase II transcription (GO:0006369)2.60741430
150mitotic spindle assembly checkpoint (GO:0007094)2.60518971
151SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.58242335
152nucleobase biosynthetic process (GO:0046112)2.57281833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.55146312
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.30110869
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.13042594
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.88923020
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.61926878
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.45433048
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.30327441
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18899863
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.98385815
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.89778531
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87697004
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79656650
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73173251
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58106020
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55027036
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54244433
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.47988875
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.47592810
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45349025
20* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41629799
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.35717465
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32176279
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31530238
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26060859
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18869901
26XRN2_22483619_ChIP-Seq_HELA_Human2.18195540
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11289807
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.06711302
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.06711302
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.06711302
31* TTF2_22483619_ChIP-Seq_HELA_Human2.03042795
32VDR_23849224_ChIP-Seq_CD4+_Human1.99163755
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98345599
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.89965891
35FOXP3_21729870_ChIP-Seq_TREG_Human1.89400668
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88401930
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.85565223
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85130365
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82129678
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80083831
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.79226741
42AR_21909140_ChIP-Seq_LNCAP_Human1.79188941
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77450616
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71241677
45DCP1A_22483619_ChIP-Seq_HELA_Human1.68809199
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.68283093
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67209722
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66839881
49* ELK1_19687146_ChIP-ChIP_HELA_Human1.64975884
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58323203
51* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.57687525
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55875127
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53575239
54GABP_19822575_ChIP-Seq_HepG2_Human1.52195369
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51610027
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48672467
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44184641
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.43917248
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42347547
60MYC_18940864_ChIP-ChIP_HL60_Human1.40747401
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40675565
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39074697
63* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38615412
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.38155542
65IRF1_19129219_ChIP-ChIP_H3396_Human1.37392419
66CIITA_25753668_ChIP-Seq_RAJI_Human1.33399313
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.32979774
68TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32066908
69EWS_26573619_Chip-Seq_HEK293_Human1.31577973
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31104674
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28338719
72* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.25661265
73* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25343738
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.21269282
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19910123
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.18018935
77NANOG_16153702_ChIP-ChIP_HESCs_Human1.17765875
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17276100
79ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17256196
80SOX17_20123909_ChIP-Seq_XEN_Mouse1.16926527
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.16106976
82FUS_26573619_Chip-Seq_HEK293_Human1.15636706
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15580470
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12958512
85* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12297009
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10597473
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10237278
88* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08625441
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08591277
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07839573
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06897199
92* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05126418
93KDM5A_27292631_Chip-Seq_BREAST_Human1.04819611
94TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02639144
95SOX2_16153702_ChIP-ChIP_HESCs_Human1.02420253
96TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01388008
97* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99382280
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99338866
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99228919
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99206503
101* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95763924
102SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95509517
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94778308
104SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93776791
105ELK1_22589737_ChIP-Seq_MCF10A_Human0.92681741
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91053154
107NANOG_21062744_ChIP-ChIP_HESCs_Human0.88968088
108SOX9_26525672_Chip-Seq_HEART_Mouse0.88856943
109* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.87669676
110NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85324095
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85174282
112* MYC_22102868_ChIP-Seq_BL_Human0.85173655
113* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84094017
114ISL1_27105846_Chip-Seq_CPCs_Mouse0.83365286
115* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82909762
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82120804
117SALL1_21062744_ChIP-ChIP_HESCs_Human0.80480237
118* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.80356966
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80094977
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78162308
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77570017
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75812418
123* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.75646091
124* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74308484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.92300156
2MP0006292_abnormal_olfactory_placode3.74620758
3MP0003111_abnormal_nucleus_morphology3.22140034
4MP0010094_abnormal_chromosome_stability3.11585456
5MP0004957_abnormal_blastocyst_morpholog3.00446124
6MP0003077_abnormal_cell_cycle2.80129608
7MP0008057_abnormal_DNA_replication2.74451073
8MP0010030_abnormal_orbit_morphology2.74228603
9MP0008058_abnormal_DNA_repair2.61619050
10MP0003136_yellow_coat_color2.52554622
11MP0008007_abnormal_cellular_replicative2.49488838
12MP0008932_abnormal_embryonic_tissue2.40590590
13MP0003315_abnormal_perineum_morphology2.29114906
14MP0002653_abnormal_ependyma_morphology2.23827517
15MP0009697_abnormal_copulation2.22803922
16MP0000566_synostosis2.22561699
17MP0003123_paternal_imprinting2.09591573
18MP0000049_abnormal_middle_ear2.09018285
19MP0008789_abnormal_olfactory_epithelium2.07656611
20MP0010352_gastrointestinal_tract_polyps1.99835808
21MP0000537_abnormal_urethra_morphology1.99094238
22MP0004272_abnormal_basement_membrane1.84007006
23MP0001188_hyperpigmentation1.83787513
24MP0002254_reproductive_system_inflammat1.79987926
25MP0005499_abnormal_olfactory_system1.74853132
26MP0005394_taste/olfaction_phenotype1.74853132
27MP0003121_genomic_imprinting1.70898334
28MP0008877_abnormal_DNA_methylation1.70229149
29MP0002751_abnormal_autonomic_nervous1.67704556
30MP0003890_abnormal_embryonic-extraembry1.66906877
31MP0003119_abnormal_digestive_system1.65704272
32MP0003937_abnormal_limbs/digits/tail_de1.65282978
33MP0000350_abnormal_cell_proliferation1.60498966
34MP0003786_premature_aging1.57009742
35MP0002938_white_spotting1.56990380
36MP0009379_abnormal_foot_pigmentation1.55045736
37MP0001299_abnormal_eye_distance/1.53485360
38MP0002249_abnormal_larynx_morphology1.53291860
39MP0000015_abnormal_ear_pigmentation1.52936345
40MP0003938_abnormal_ear_development1.51881686
41MP0003718_maternal_effect1.50817572
42MP0001672_abnormal_embryogenesis/_devel1.47705985
43MP0005380_embryogenesis_phenotype1.47705985
44MP0002085_abnormal_embryonic_tissue1.46536759
45MP0001293_anophthalmia1.41062658
46MP0002160_abnormal_reproductive_system1.41046792
47MP0003122_maternal_imprinting1.39515866
48MP0005409_darkened_coat_color1.39142640
49MP0003385_abnormal_body_wall1.35571818
50MP0010307_abnormal_tumor_latency1.35109399
51MP0009053_abnormal_anal_canal1.34282485
52MP0005075_abnormal_melanosome_morpholog1.32489513
53MP0000428_abnormal_craniofacial_morphol1.32071764
54MP0000490_abnormal_crypts_of1.29563031
55MP0004133_heterotaxia1.29058852
56MP0003705_abnormal_hypodermis_morpholog1.28402780
57MP0002177_abnormal_outer_ear1.27956122
58MP0004381_abnormal_hair_follicle1.26101640
59MP0003567_abnormal_fetal_cardiomyocyte1.24382697
60MP0003941_abnormal_skin_development1.22819085
61MP0009250_abnormal_appendicular_skeleto1.22329242
62MP0002210_abnormal_sex_determination1.21040338
63MP0002102_abnormal_ear_morphology1.20103813
64MP0001730_embryonic_growth_arrest1.19211457
65MP0003984_embryonic_growth_retardation1.19044295
66MP0002084_abnormal_developmental_patter1.18695340
67MP0002638_abnormal_pupillary_reflex1.18193610
68MP0008260_abnormal_autophagy1.17956644
69MP0002088_abnormal_embryonic_growth/wei1.17392517
70MP0001697_abnormal_embryo_size1.17087995
71MP0005174_abnormal_tail_pigmentation1.16333272
72MP0002111_abnormal_tail_morphology1.15997748
73MP0000678_abnormal_parathyroid_gland1.15406097
74MP0003755_abnormal_palate_morphology1.13787627
75MP0003566_abnormal_cell_adhesion1.12731645
76MP0002233_abnormal_nose_morphology1.12233373
77MP0000432_abnormal_head_morphology1.07800665
78MP0002932_abnormal_joint_morphology1.07471117
79MP0001286_abnormal_eye_development1.07146787
80MP0005623_abnormal_meninges_morphology1.07104667
81MP0009672_abnormal_birth_weight1.06313399
82MP0004197_abnormal_fetal_growth/weight/1.04675701
83MP0001346_abnormal_lacrimal_gland1.04447100
84MP0000313_abnormal_cell_death1.02891984
85MP0001119_abnormal_female_reproductive1.02224361
86MP0003935_abnormal_craniofacial_develop1.01881637
87MP0002080_prenatal_lethality1.00700435
88MP0000372_irregular_coat_pigmentation0.99551248
89MP0002116_abnormal_craniofacial_bone0.99100535
90MP0000579_abnormal_nail_morphology0.97879201
91MP0003942_abnormal_urinary_system0.95506692
92MP0005076_abnormal_cell_differentiation0.95355664
93MP0001145_abnormal_male_reproductive0.95026860
94MP0002114_abnormal_axial_skeleton0.94569290
95MP0001849_ear_inflammation0.93718618
96MP0009703_decreased_birth_body0.93292105
97MP0000631_abnormal_neuroendocrine_gland0.91442000
98MP0001929_abnormal_gametogenesis0.88912178
99MP0001915_intracranial_hemorrhage0.88656971
100MP0005389_reproductive_system_phenotype0.87808480
101MP0003115_abnormal_respiratory_system0.87100915
102MP0000647_abnormal_sebaceous_gland0.86513533
103MP0000653_abnormal_sex_gland0.86453607
104MP0002396_abnormal_hematopoietic_system0.86247236
105MP0003861_abnormal_nervous_system0.85085463
106MP0002081_perinatal_lethality0.82772013
107MP0002086_abnormal_extraembryonic_tissu0.82043137
108MP0000762_abnormal_tongue_morphology0.81170703
109MP0002019_abnormal_tumor_incidence0.80255202
110MP0002089_abnormal_postnatal_growth/wei0.80082074
111MP0002095_abnormal_skin_pigmentation0.79398326
112MP0002092_abnormal_eye_morphology0.78815820
113MP0000613_abnormal_salivary_gland0.78629716
114MP0005391_vision/eye_phenotype0.77823209
115MP0005367_renal/urinary_system_phenotyp0.77413918
116MP0000516_abnormal_urinary_system0.77413918
117MP0009333_abnormal_splenocyte_physiolog0.77124952
118MP0002697_abnormal_eye_size0.75683850
119MP0005257_abnormal_intraocular_pressure0.75538514
120MP0001919_abnormal_reproductive_system0.74560083
121MP0005197_abnormal_uvea_morphology0.74240936
122MP0001661_extended_life_span0.73757446
123MP0000778_abnormal_nervous_system0.73660842
124MP0004233_abnormal_muscle_weight0.71412990
125MP0002925_abnormal_cardiovascular_devel0.70952457
126MP0000534_abnormal_ureter_morphology0.69463974
127MP0001529_abnormal_vocalization0.66622089
128MP0005395_other_phenotype0.64700619
129MP0005187_abnormal_penis_morphology0.64558204
130MP0008770_decreased_survivor_rate0.64132581
131MP0003950_abnormal_plasma_membrane0.62363976

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.10672530
2Type I transferrin isoform profile (HP:0003642)3.83578211
3Chromsome breakage (HP:0040012)3.83482428
4Meckel diverticulum (HP:0002245)3.47073240
5Impulsivity (HP:0100710)3.31927457
6Abnormality of the ileum (HP:0001549)3.30243149
7Abnormal lung lobation (HP:0002101)3.27780098
8Nephroblastoma (Wilms tumor) (HP:0002667)3.24867032
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.24120315
10Aplasia/Hypoplasia of the sacrum (HP:0008517)3.22518959
11Supernumerary spleens (HP:0009799)3.21735298
12Cortical dysplasia (HP:0002539)3.13759867
13Degeneration of anterior horn cells (HP:0002398)3.12005045
14Abnormality of the anterior horn cell (HP:0006802)3.12005045
15Reticulocytopenia (HP:0001896)3.10058912
16Rib fusion (HP:0000902)3.08421468
17Embryonal renal neoplasm (HP:0011794)3.04602197
18Reduced antithrombin III activity (HP:0001976)2.97945904
19Aplasia/Hypoplasia of the patella (HP:0006498)2.97170896
20Abnormality of the preputium (HP:0100587)2.93742844
21Increased nuchal translucency (HP:0010880)2.89516875
22Abnormality of the labia minora (HP:0012880)2.87811025
23Breast hypoplasia (HP:0003187)2.82104486
24Patellar aplasia (HP:0006443)2.81131889
25Abnormality of the phalanges of the hallux (HP:0010057)2.75299565
26Hepatoblastoma (HP:0002884)2.73846437
27Triphalangeal thumb (HP:0001199)2.70334976
28Ectopic kidney (HP:0000086)2.64896589
29Spastic diplegia (HP:0001264)2.62873169
30Abnormality of chromosome stability (HP:0003220)2.61989824
31Birth length less than 3rd percentile (HP:0003561)2.60260660
32Duodenal stenosis (HP:0100867)2.57508375
33Small intestinal stenosis (HP:0012848)2.57508375
34Short middle phalanx of the 5th finger (HP:0004220)2.55361043
35Medulloblastoma (HP:0002885)2.54796333
36Absent radius (HP:0003974)2.50931440
37Absent thumb (HP:0009777)2.48905199
38Rhabdomyosarcoma (HP:0002859)2.44510613
39Aplastic anemia (HP:0001915)2.42226114
40Septo-optic dysplasia (HP:0100842)2.41168221
41Rectal fistula (HP:0100590)2.39784084
42Rectovaginal fistula (HP:0000143)2.39784084
43Absent forearm bone (HP:0003953)2.35735636
44Aplasia involving forearm bones (HP:0009822)2.35735636
45Aplasia/Hypoplasia of the sternum (HP:0006714)2.34071899
46Esophageal atresia (HP:0002032)2.25847205
47Abnormal number of incisors (HP:0011064)2.23773255
48Capillary hemangiomas (HP:0005306)2.23251234
49Abnormality of the duodenum (HP:0002246)2.22807127
50Abnormality of abdominal situs (HP:0011620)2.19582068
51Abdominal situs inversus (HP:0003363)2.19582068
52Selective tooth agenesis (HP:0001592)2.18439021
53Choanal stenosis (HP:0000452)2.14073950
54Intestinal fistula (HP:0100819)2.13050467
55Gastrointestinal carcinoma (HP:0002672)2.11715505
56Malignant gastrointestinal tract tumors (HP:0006749)2.11715505
57Abnormality of cells of the erythroid lineage (HP:0012130)2.08680908
58Anophthalmia (HP:0000528)2.07668097
59Ependymoma (HP:0002888)2.05112846
60Skull defect (HP:0001362)2.05057682
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05054060
62Abnormal protein N-linked glycosylation (HP:0012347)2.05054060
63Abnormal protein glycosylation (HP:0012346)2.05054060
64Abnormal glycosylation (HP:0012345)2.05054060
65Horseshoe kidney (HP:0000085)2.04896645
66Clubbing of toes (HP:0100760)2.04630579
67Myelodysplasia (HP:0002863)2.04594903
68Intestinal atresia (HP:0011100)2.03912198
69Myelomeningocele (HP:0002475)2.02760030
70Stenosis of the external auditory canal (HP:0000402)2.02279114
71Tracheoesophageal fistula (HP:0002575)2.00360924
72Sex reversal (HP:0012245)1.99966621
73Abnormal sex determination (HP:0012244)1.99966621
74Sloping forehead (HP:0000340)1.99942132
75Atresia of the external auditory canal (HP:0000413)1.98013960
76Broad thumb (HP:0011304)1.97726538
77Abnormality of the septum pellucidum (HP:0007375)1.97584422
78Carpal bone hypoplasia (HP:0001498)1.95433012
79Pendular nystagmus (HP:0012043)1.94607494
80Bilateral microphthalmos (HP:0007633)1.94114726
81Trigonocephaly (HP:0000243)1.94096930
82Abnormal number of erythroid precursors (HP:0012131)1.92519020
83Short thumb (HP:0009778)1.92511052
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92365536
85Bifid tongue (HP:0010297)1.92027584
86Pancreatic cysts (HP:0001737)1.91799458
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91556049
88Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.91542014
89Colon cancer (HP:0003003)1.91499817
90High anterior hairline (HP:0009890)1.91298135
91Neoplasm of the colon (HP:0100273)1.90826157
92Severe visual impairment (HP:0001141)1.90364338
93Hypoplasia of the radius (HP:0002984)1.90353695
94Hypoplasia of the fovea (HP:0007750)1.90011606
95Aplasia/Hypoplasia of the fovea (HP:0008060)1.90011606
96Cleft eyelid (HP:0000625)1.89760830
97Gastrointestinal atresia (HP:0002589)1.89201990
98Bone marrow hypocellularity (HP:0005528)1.86976193
99Pancreatic islet-cell hyperplasia (HP:0004510)1.86750694
100Maternal diabetes (HP:0009800)1.86591414
101Biliary tract neoplasm (HP:0100574)1.86133194
102Partial duplication of thumb phalanx (HP:0009944)1.84976421
103Aplasia/Hypoplasia of the breasts (HP:0010311)1.84325392
104Breast aplasia (HP:0100783)1.84088834
105Preaxial hand polydactyly (HP:0001177)1.83492037
106Preaxial foot polydactyly (HP:0001841)1.83250038
107Absent septum pellucidum (HP:0001331)1.82947188
108Volvulus (HP:0002580)1.82861645
109Cutaneous syndactyly (HP:0012725)1.80843926
110Anencephaly (HP:0002323)1.80705941
111Coronal craniosynostosis (HP:0004440)1.80595051
112Abnormality of the carotid arteries (HP:0005344)1.80060032
113Abnormality of the lacrimal duct (HP:0011481)1.79440250
114Uterine neoplasm (HP:0010784)1.79343955
115Optic nerve hypoplasia (HP:0000609)1.78630309
116Leiomyosarcoma (HP:0100243)1.78462463
117Uterine leiomyosarcoma (HP:0002891)1.78462463
118Vaginal fistula (HP:0004320)1.78153844
119Oral leukoplakia (HP:0002745)1.75444169
120Neoplasm of striated muscle (HP:0009728)1.74920553
121Deviation of the thumb (HP:0009603)1.74593663
122Macrocytic anemia (HP:0001972)1.74207875
123Carpal synostosis (HP:0009702)1.73885460
124Cutaneous finger syndactyly (HP:0010554)1.73472458
125Embryonal neoplasm (HP:0002898)1.73449371
126Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.72270606
127Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.71957425
128Renal duplication (HP:0000075)1.71826996
129Pallor (HP:0000980)1.71639931
130Premature graying of hair (HP:0002216)1.71170394
131Overriding aorta (HP:0002623)1.70892203
132Optic nerve coloboma (HP:0000588)1.69818069
133Microvesicular hepatic steatosis (HP:0001414)1.69379100
134Multiple enchondromatosis (HP:0005701)1.68586447
135Aplasia/hypoplasia of the humerus (HP:0006507)1.68515938
136Absent eyebrow (HP:0002223)1.68504917
137Duplication of thumb phalanx (HP:0009942)1.68070557
138Aqueductal stenosis (HP:0002410)1.67160103
139Facial cleft (HP:0002006)1.66927541
140Duplicated collecting system (HP:0000081)1.66671738
141Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66230639
142Proximal placement of thumb (HP:0009623)1.66041181
143Shallow orbits (HP:0000586)1.65915874
144Partial agenesis of the corpus callosum (HP:0001338)1.65499030
145Missing ribs (HP:0000921)1.64004505
146Glioma (HP:0009733)1.63197991
147Irregular epiphyses (HP:0010582)1.62762539
148Omphalocele (HP:0001539)1.59864678
149Partial duplication of the phalanx of hand (HP:0009999)1.59827917
150Vertebral clefting (HP:0008428)1.59015534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK24.61185561
2MKNK14.51889767
3SRPK14.00176152
4CDC73.58236750
5TLK13.36292858
6EIF2AK33.35204390
7WEE12.94302221
8BUB12.80782098
9EIF2AK22.58096018
10NME22.44391540
11TAF12.25170836
12NLK2.23114169
13PLK42.19691937
14TTK2.03885872
15NEK22.01058500
16VRK21.97554303
17EIF2AK11.93349805
18EEF2K1.86258973
19NEK11.78872853
20LATS11.78696231
21STK161.76739807
22PLK11.74801546
23CASK1.71559442
24TNIK1.64930863
25CDK71.61588008
26ZAK1.54860277
27PASK1.50129891
28SMG11.49861879
29CDK121.48221857
30CHEK21.41403351
31ERBB41.36230505
32TESK21.34825912
33PLK31.33783869
34AURKA1.31455810
35VRK11.31309706
36FGFR11.28586058
37AURKB1.28237511
38CAMK1G1.26785951
39STK38L1.26266838
40BRSK21.23565581
41MET1.22527046
42DYRK31.22225970
43FGFR21.19230249
44YES11.17973662
45CLK11.14067451
46ATR1.13897625
47MST41.11547373
48PDGFRA1.09933025
49ACVR1B1.08386119
50BMX1.03957273
51FLT31.02941233
52CDK190.99101039
53CAMK1D0.98631729
54BRAF0.96984591
55CDK40.95869213
56IRAK40.95473323
57RPS6KA40.93405925
58MUSK0.88960539
59NUAK10.87793544
60BCR0.87534783
61TAOK20.87456320
62NTRK10.87361319
63CHEK10.86976909
64MAP3K90.83823624
65LATS20.80327649
66TRIM280.79647337
67DYRK20.78905822
68PIM10.76896673
69TIE10.76678446
70AKT30.76641146
71CSNK1G10.74728303
72TYRO30.74597398
73WNK30.71774724
74MAPK130.71595077
75CSNK2A10.71004324
76PRKD20.70865383
77TSSK60.70602214
78ICK0.70529762
79TEC0.69632353
80ATM0.69219620
81CDK20.68764371
82BRD40.65455124
83MAP3K80.64984245
84ADRBK20.63768840
85CDK80.62355901
86TGFBR10.61850287
87RPS6KB20.61810903
88PIM20.61302564
89MELK0.61283493
90STK240.61246847
91MAP2K30.61050523
92PAK10.60247587
93BMPR1B0.60236543
94STK100.59970069
95PTK20.58441173
96IRAK30.57751278
97ALK0.56930662
98PLK20.56078342
99TESK10.54650093
100NME10.54307316
101CSNK2A20.53222128
102CDK10.52564819
103ERBB30.52256698
104DYRK1A0.52014367
105PRKDC0.50654828
106PAK40.49741730
107STK40.48640961
108GRK60.47791042
109CDK90.47348223
110EPHA20.46690682
111PRKCI0.45695730
112CDK30.44169987
113EPHB20.43992345
114MTOR0.43809486
115PAK20.41846292
116BRSK10.41138639
117FGFR40.40428959
118RPS6KA50.38095041
119CDK180.36943211
120PNCK0.36144574
121CDK11A0.36136101
122AKT10.36070665
123CDK150.35463318
124NTRK20.35000393
125MAP2K60.34453781
126MAP3K40.34221078
127STK380.33788031
128EPHA40.33271362
129BTK0.31867762
130UHMK10.31391449
131MAP3K110.29963142
132IRAK20.29063832
133STK30.27624685
134ZAP700.27255898
135MAPK140.27167795
136CSNK1E0.26511332
137PBK0.26092234
138IKBKB0.24888859
139CDK60.24498139
140MAP3K100.23240477
141CSNK1G30.22163392
142RPS6KC10.21208765
143RPS6KL10.21208765
144SGK20.20851265

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.58725512
2Mismatch repair_Homo sapiens_hsa034303.78649251
3Homologous recombination_Homo sapiens_hsa034403.50331173
4Ribosome_Homo sapiens_hsa030103.41640080
5Spliceosome_Homo sapiens_hsa030403.31728223
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17969497
7RNA polymerase_Homo sapiens_hsa030203.09529763
8Base excision repair_Homo sapiens_hsa034102.95717878
9Fanconi anemia pathway_Homo sapiens_hsa034602.90073616
10RNA transport_Homo sapiens_hsa030132.79363356
11Cell cycle_Homo sapiens_hsa041102.69446699
12Nucleotide excision repair_Homo sapiens_hsa034202.64610915
13Basal transcription factors_Homo sapiens_hsa030222.52546796
14Proteasome_Homo sapiens_hsa030502.51195282
15One carbon pool by folate_Homo sapiens_hsa006702.43898915
16Pyrimidine metabolism_Homo sapiens_hsa002402.25544497
17RNA degradation_Homo sapiens_hsa030182.04894498
18mRNA surveillance pathway_Homo sapiens_hsa030151.92515340
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.90766371
20Non-homologous end-joining_Homo sapiens_hsa034501.79168913
21p53 signaling pathway_Homo sapiens_hsa041151.70110756
22Steroid biosynthesis_Homo sapiens_hsa001001.58229673
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55547090
24Biosynthesis of amino acids_Homo sapiens_hsa012301.54326648
25Basal cell carcinoma_Homo sapiens_hsa052171.42878135
26Purine metabolism_Homo sapiens_hsa002301.35430366
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33010620
28Thyroid cancer_Homo sapiens_hsa052161.31764509
29Lysine degradation_Homo sapiens_hsa003101.18593106
30Herpes simplex infection_Homo sapiens_hsa051681.08962843
31Pyruvate metabolism_Homo sapiens_hsa006201.08655256
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08208333
33Systemic lupus erythematosus_Homo sapiens_hsa053221.06054144
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05712333
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00962813
36ECM-receptor interaction_Homo sapiens_hsa045121.00893229
37Epstein-Barr virus infection_Homo sapiens_hsa051690.99502608
38Protein export_Homo sapiens_hsa030600.98377126
39Arachidonic acid metabolism_Homo sapiens_hsa005900.97594915
40Tight junction_Homo sapiens_hsa045300.96954422
41Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96079792
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90007162
43Hedgehog signaling pathway_Homo sapiens_hsa043400.89259478
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85242125
45Oocyte meiosis_Homo sapiens_hsa041140.83717240
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83661123
47Wnt signaling pathway_Homo sapiens_hsa043100.82167907
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81912052
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.81027817
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79941980
51Hippo signaling pathway_Homo sapiens_hsa043900.79927028
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79152774
53MicroRNAs in cancer_Homo sapiens_hsa052060.77984988
54Carbon metabolism_Homo sapiens_hsa012000.77647285
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77525318
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76231711
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75744746
58Notch signaling pathway_Homo sapiens_hsa043300.73098547
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72416254
60HTLV-I infection_Homo sapiens_hsa051660.70806086
61Viral carcinogenesis_Homo sapiens_hsa052030.69843850
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68489979
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68396909
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65609686
65N-Glycan biosynthesis_Homo sapiens_hsa005100.65032007
66Propanoate metabolism_Homo sapiens_hsa006400.63010341
67Sulfur relay system_Homo sapiens_hsa041220.61308896
68Proteoglycans in cancer_Homo sapiens_hsa052050.58497740
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54989869
70Axon guidance_Homo sapiens_hsa043600.54949441
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.53040973
72Selenocompound metabolism_Homo sapiens_hsa004500.53009842
73TGF-beta signaling pathway_Homo sapiens_hsa043500.52451892
74Huntingtons disease_Homo sapiens_hsa050160.52328046
75Prostate cancer_Homo sapiens_hsa052150.49554746
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49378526
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47672527
78Pathways in cancer_Homo sapiens_hsa052000.47104943
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46260199
80Antigen processing and presentation_Homo sapiens_hsa046120.46258685
81Bladder cancer_Homo sapiens_hsa052190.44760593
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44553704
83Measles_Homo sapiens_hsa051620.44116367
84Alcoholism_Homo sapiens_hsa050340.43631104
85Gap junction_Homo sapiens_hsa045400.43395233
86Linoleic acid metabolism_Homo sapiens_hsa005910.43103532
87Vitamin digestion and absorption_Homo sapiens_hsa049770.41422599
88Small cell lung cancer_Homo sapiens_hsa052220.41216601
89Asthma_Homo sapiens_hsa053100.41094223
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40813611
91Focal adhesion_Homo sapiens_hsa045100.39835169
92Endometrial cancer_Homo sapiens_hsa052130.39532370
93Colorectal cancer_Homo sapiens_hsa052100.38948659
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38733604
95Vitamin B6 metabolism_Homo sapiens_hsa007500.38580960
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38037083
97Graft-versus-host disease_Homo sapiens_hsa053320.37845552
98Adherens junction_Homo sapiens_hsa045200.36311815
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35878986
100Primary immunodeficiency_Homo sapiens_hsa053400.35335425
101Allograft rejection_Homo sapiens_hsa053300.33470027
102Fatty acid elongation_Homo sapiens_hsa000620.33029518
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32505741
104Chronic myeloid leukemia_Homo sapiens_hsa052200.32341187
105Sphingolipid metabolism_Homo sapiens_hsa006000.32124389
106Arginine and proline metabolism_Homo sapiens_hsa003300.31251840
107Phototransduction_Homo sapiens_hsa047440.31187860
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31074826
109Glutathione metabolism_Homo sapiens_hsa004800.31036316
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30609238
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.29647921
112Apoptosis_Homo sapiens_hsa042100.28545539
113Other glycan degradation_Homo sapiens_hsa005110.28129281
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27978304
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27868728
116Legionellosis_Homo sapiens_hsa051340.26167548
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26096845
118Thyroid hormone synthesis_Homo sapiens_hsa049180.25945683
119Melanoma_Homo sapiens_hsa052180.24528070
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24407168
121Galactose metabolism_Homo sapiens_hsa000520.24347775
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24159714
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24089388
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23925777
125Ether lipid metabolism_Homo sapiens_hsa005650.23918420
126Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23785577
127Fatty acid metabolism_Homo sapiens_hsa012120.23080681
128Autoimmune thyroid disease_Homo sapiens_hsa053200.22366184
129Folate biosynthesis_Homo sapiens_hsa007900.21885607
130Hepatitis B_Homo sapiens_hsa051610.20668957
131Pentose phosphate pathway_Homo sapiens_hsa000300.20646379
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.20490358
133Melanogenesis_Homo sapiens_hsa049160.20214579
134Acute myeloid leukemia_Homo sapiens_hsa052210.19814712
135Influenza A_Homo sapiens_hsa051640.19745823
136Hematopoietic cell lineage_Homo sapiens_hsa046400.19082384
137Regulation of autophagy_Homo sapiens_hsa041400.18940190
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18185893
139Metabolic pathways_Homo sapiens_hsa011000.15959060
140Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15752984

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