IGFALS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.90393572
2omega-hydroxylase P450 pathway (GO:0097267)7.71491366
3L-phenylalanine catabolic process (GO:0006559)7.51576017
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.51576017
5exogenous drug catabolic process (GO:0042738)7.38632069
6L-phenylalanine metabolic process (GO:0006558)7.18487770
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.18487770
8aromatic amino acid family catabolic process (GO:0009074)6.69791680
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.18857355
10indole-containing compound catabolic process (GO:0042436)5.98167129
11indolalkylamine catabolic process (GO:0046218)5.98167129
12tryptophan catabolic process (GO:0006569)5.98167129
13kynurenine metabolic process (GO:0070189)5.86360191
14oxidative demethylation (GO:0070989)5.84427936
15bile acid biosynthetic process (GO:0006699)5.78461134
16tryptophan metabolic process (GO:0006568)5.65068602
17alpha-linolenic acid metabolic process (GO:0036109)5.63164839
18regulation of plasminogen activation (GO:0010755)5.62968791
19drug metabolic process (GO:0017144)5.62404703
20glyoxylate metabolic process (GO:0046487)5.57902714
21urea cycle (GO:0000050)5.57870263
22urea metabolic process (GO:0019627)5.57870263
23phenylpropanoid metabolic process (GO:0009698)5.50885182
24high-density lipoprotein particle remodeling (GO:0034375)5.45044650
25negative regulation of fibrinolysis (GO:0051918)5.40116416
26ethanol metabolic process (GO:0006067)5.39838650
27sulfur amino acid catabolic process (GO:0000098)5.33154139
28protein carboxylation (GO:0018214)5.28168275
29peptidyl-glutamic acid carboxylation (GO:0017187)5.28168275
30cysteine metabolic process (GO:0006534)5.27735654
31complement activation, alternative pathway (GO:0006957)5.23857504
32regulation of fibrinolysis (GO:0051917)5.22876926
33nitrogen cycle metabolic process (GO:0071941)5.13392895
34regulation of protein activation cascade (GO:2000257)5.11915670
35acute-phase response (GO:0006953)5.10850051
36opsonization (GO:0008228)5.05289674
37serine family amino acid catabolic process (GO:0009071)5.02874350
38bile acid metabolic process (GO:0008206)5.00431221
39aromatic amino acid family metabolic process (GO:0009072)4.86992864
40negative regulation of blood coagulation (GO:0030195)4.84207582
41negative regulation of hemostasis (GO:1900047)4.84207582
42regulation of complement activation (GO:0030449)4.78836094
43regulation of humoral immune response (GO:0002920)4.76749588
44regulation of triglyceride catabolic process (GO:0010896)4.75272474
45reverse cholesterol transport (GO:0043691)4.75241666
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.74789749
47tyrosine metabolic process (GO:0006570)4.74458732
48regulation of cholesterol esterification (GO:0010872)4.71661997
49homocysteine metabolic process (GO:0050667)4.66397068
50protein-lipid complex remodeling (GO:0034368)4.65270778
51macromolecular complex remodeling (GO:0034367)4.65270778
52plasma lipoprotein particle remodeling (GO:0034369)4.65270778
53acylglycerol homeostasis (GO:0055090)4.64855776
54triglyceride homeostasis (GO:0070328)4.64855776
55lysine catabolic process (GO:0006554)4.58615365
56lysine metabolic process (GO:0006553)4.58615365
57alpha-amino acid catabolic process (GO:1901606)4.57717190
58alkaloid metabolic process (GO:0009820)4.54163730
59amino-acid betaine metabolic process (GO:0006577)4.47997682
60negative regulation of protein activation cascade (GO:2000258)4.46862021
61cellular ketone body metabolic process (GO:0046950)4.44994659
62phospholipid efflux (GO:0033700)4.41760926
63negative regulation of sterol transport (GO:0032372)4.41467559
64negative regulation of cholesterol transport (GO:0032375)4.41467559
65negative regulation of coagulation (GO:0050819)4.39971391
66imidazole-containing compound metabolic process (GO:0052803)4.39419354
67negative regulation of wound healing (GO:0061045)4.38447727
68plasma lipoprotein particle clearance (GO:0034381)4.37800349
69coenzyme catabolic process (GO:0009109)4.32378706
70bile acid and bile salt transport (GO:0015721)4.30395344
71glycine metabolic process (GO:0006544)4.27535402
72indolalkylamine metabolic process (GO:0006586)4.27282973
73cellular amino acid catabolic process (GO:0009063)4.23687091
74glutamate metabolic process (GO:0006536)4.13559007
75amine catabolic process (GO:0009310)4.12424021
76cellular biogenic amine catabolic process (GO:0042402)4.12424021
77cellular glucuronidation (GO:0052695)4.10099348
78positive regulation of blood coagulation (GO:0030194)4.09803369
79positive regulation of hemostasis (GO:1900048)4.09803369
80cholesterol efflux (GO:0033344)4.07954968
81serine family amino acid metabolic process (GO:0009069)4.05289934
82cellular modified amino acid catabolic process (GO:0042219)4.01164711
83ethanol oxidation (GO:0006069)4.00643421
84S-adenosylmethionine metabolic process (GO:0046500)4.00027561
85benzene-containing compound metabolic process (GO:0042537)3.98963492
86low-density lipoprotein particle remodeling (GO:0034374)3.89838243
87arginine metabolic process (GO:0006525)3.89277349
88acute inflammatory response (GO:0002526)3.88214070
89plasma lipoprotein particle assembly (GO:0034377)3.86511335
90negative regulation of complement activation (GO:0045916)3.86101888
91ketone body metabolic process (GO:1902224)3.84885305
92fibrinolysis (GO:0042730)3.84124520
93dicarboxylic acid biosynthetic process (GO:0043650)3.82071498
94drug catabolic process (GO:0042737)3.81503310
95serine family amino acid biosynthetic process (GO:0009070)3.81272355
96aldehyde catabolic process (GO:0046185)3.78449538
97positive regulation of coagulation (GO:0050820)3.78162571
98acetyl-CoA metabolic process (GO:0006084)3.76102283
99short-chain fatty acid metabolic process (GO:0046459)3.73769597
100organic acid catabolic process (GO:0016054)3.73623302
101carboxylic acid catabolic process (GO:0046395)3.73623302
102positive regulation of lipoprotein lipase activity (GO:0051006)3.72883922
103positive regulation of triglyceride lipase activity (GO:0061365)3.72883922
104steroid catabolic process (GO:0006706)3.72463072
105killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.72250602
106disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.72250602
107positive regulation of lipid catabolic process (GO:0050996)3.70801051
108regulation of lipoprotein particle clearance (GO:0010984)3.70277431
109regulation of bile acid biosynthetic process (GO:0070857)3.69465525
110phospholipid homeostasis (GO:0055091)3.68929263
111cholesterol homeostasis (GO:0042632)3.68197059
112blood coagulation, intrinsic pathway (GO:0007597)3.67996777
113positive regulation of fatty acid biosynthetic process (GO:0045723)3.67906475
114cofactor catabolic process (GO:0051187)3.67736984
115negative regulation of lipase activity (GO:0060192)3.67630208
116regulation of cholesterol homeostasis (GO:2000188)3.63793741
117complement activation, classical pathway (GO:0006958)3.63763278
118glucuronate metabolic process (GO:0019585)3.63330434
119uronic acid metabolic process (GO:0006063)3.63330434
120sterol homeostasis (GO:0055092)3.62543466
121complement activation (GO:0006956)3.61873365
122very-low-density lipoprotein particle assembly (GO:0034379)3.58628449
123protein activation cascade (GO:0072376)3.58599890
124peptidyl-glutamic acid modification (GO:0018200)3.58380566
125cytolysis (GO:0019835)3.55198630
126plasma lipoprotein particle organization (GO:0071827)3.53278791
127monocarboxylic acid catabolic process (GO:0072329)3.46805113
128protein-lipid complex assembly (GO:0065005)3.46221242
1292-oxoglutarate metabolic process (GO:0006103)3.46026321
130heme transport (GO:0015886)3.45158391
131proline metabolic process (GO:0006560)3.44550960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.29251125
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.11504724
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.82423913
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.47323950
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.25616523
6* PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.04198992
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.00396770
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.01052968
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.80407428
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15652342
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02831806
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6717013
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97503278
14CLOCK_20551151_ChIP-Seq_293T_Human1.72107340
15* FOXA2_19822575_ChIP-Seq_HepG2_Human1.61539228
16GATA1_22025678_ChIP-Seq_K562_Human1.52372088
17HTT_18923047_ChIP-ChIP_STHdh_Human1.50927861
18* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43897126
19HNF4A_19822575_ChIP-Seq_HepG2_Human1.40136053
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39971998
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36838781
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29916406
23ELF1_20517297_ChIP-Seq_JURKAT_Human1.21851999
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17567776
25* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16158502
26E2F1_20622854_ChIP-Seq_HELA_Human1.14264416
27* CTCF_27219007_Chip-Seq_Bcells_Human1.13516381
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03863909
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03755272
30BCOR_27268052_Chip-Seq_Bcells_Human1.02505719
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02368068
32DROSHA_22980978_ChIP-Seq_HELA_Human1.02080522
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00113254
34PHF8_20622854_ChIP-Seq_HELA_Human0.99809534
35BCL6_27268052_Chip-Seq_Bcells_Human0.98647550
36* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96464622
37CTCF_20526341_ChIP-Seq_ESCs_Human0.95414653
38P68_20966046_ChIP-Seq_HELA_Human0.94842123
39RAC3_21632823_ChIP-Seq_H3396_Human0.94816379
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91847809
41SMC4_20622854_ChIP-Seq_HELA_Human0.91418395
42OCT4_20526341_ChIP-Seq_ESCs_Human0.91209791
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91120458
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90611685
45SOX2_21211035_ChIP-Seq_LN229_Human0.90538382
46* TET1_21451524_ChIP-Seq_MESCs_Mouse0.90435839
47* ERA_21632823_ChIP-Seq_H3396_Human0.90044848
48DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89961652
49SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89822052
50RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89281553
51GATA4_25053715_ChIP-Seq_YYC3_Human0.88201619
52IRF8_22096565_ChIP-ChIP_GC-B_Human0.86794659
53P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85642854
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84202206
55EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83307000
56MYC_19829295_ChIP-Seq_ESCs_Human0.83038363
57JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.82893443
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81954023
59ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81541795
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81313668
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81292811
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81157984
63SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80733039
64P300_27268052_Chip-Seq_Bcells_Human0.79522652
65AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79305970
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78317052
67ESR2_21235772_ChIP-Seq_MCF-7_Human0.78107292
68IRF1_19129219_ChIP-ChIP_H3396_Human0.77682937
69KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76120824
70ZNF263_19887448_ChIP-Seq_K562_Human0.75478961
71* SA1_27219007_Chip-Seq_Bcells_Human0.75369409
72* RARA_24833708_ChIP-Seq_LIVER_Mouse0.74569025
73TRIM28_21343339_ChIP-Seq_HEK293_Human0.74302652
74AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74289440
75NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.73913932
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73192565
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69117424
78* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69013775
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68171811
80ESR1_21235772_ChIP-Seq_MCF-7_Human0.68157711
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.67865223
82CTCF_21964334_ChIP-Seq_BJAB-B_Human0.67307953
83CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.67237670
84SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67115329
85NANOG_20526341_ChIP-Seq_ESCs_Human0.66997331
86CTCF_21964334_Chip-Seq_Bcells_Human0.65741541
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.65400128
88SPI1_20517297_ChIP-Seq_HL60_Human0.64771858
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64624520
90NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64624520
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.64461820
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63709458
93NCOR_22424771_ChIP-Seq_293T_Human0.63557803
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.63520942
95* RARB_24833708_ChIP-Seq_LIVER_Mouse0.63482351
96RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63267782
97FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62137800
98FOXA1_25552417_ChIP-Seq_VCAP_Human0.62075182
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.61814528
100HNFA_21074721_ChIP-Seq_CACO-2_Human0.61252031
101BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61008502
102SA1_27219007_Chip-Seq_ERYTHROID_Human0.60528081
103PHF8_20622853_ChIP-Seq_HELA_Human0.60504154
104GATA3_21867929_ChIP-Seq_CD8_Mouse0.60288208
105SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.60079851
106GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.59999195
107LXR_22292898_ChIP-Seq_THP-1_Human0.58988554
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57742546
109CEBPB_22108803_ChIP-Seq_LS180_Human0.56941312
110FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55250731
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55206967
112AR_20517297_ChIP-Seq_VCAP_Human0.52737464
113ESET_19884257_ChIP-Seq_ESCs_Mouse0.52056224
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.51358765
115NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.51085067
116CBP_21632823_ChIP-Seq_H3396_Human0.50733423
117PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.50687070
118STAT1_17558387_ChIP-Seq_HELA_Human0.50394676
119GATA1_19941826_ChIP-Seq_K562_Human0.49267489
120EGR1_19032775_ChIP-ChIP_M12_Human0.49228506
121* MYC_19915707_ChIP-ChIP_AK7_Human0.48948454
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.48534239
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48432584
124P53_21459846_ChIP-Seq_SAOS-2_Human0.47937609
125PPAR_26484153_Chip-Seq_NCI-H1993_Human0.45092068
126GATA6_25053715_ChIP-Seq_YYC3_Human0.44102080
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.43654531
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43523318
129* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43090784
130* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.43000724
131BCAT_22108803_ChIP-Seq_LS180_Human0.42878997
132GATA2_19941826_ChIP-Seq_K562_Human0.42230276
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.41776877
134TAF2_19829295_ChIP-Seq_ESCs_Human0.40889723
135GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.40805516
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40687159
137CDX2_20551321_ChIP-Seq_CACO-2_Human0.40619720
138ERG_20517297_ChIP-Seq_VCAP_Human0.40567263
139SOX2_20726797_ChIP-Seq_SW620_Human0.39735662
140GATA3_24758297_ChIP-Seq_MCF-7_Human0.39683673
141GATA1_19941827_ChIP-Seq_MEL_Mouse0.39630227
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.39359734
143MYC_27129775_Chip-Seq_CORNEA_Mouse0.39068390
144PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.38844245
145STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37308565
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.37306700
147CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.36896598
148SPI1_26923725_Chip-Seq_HPCs_Mouse0.36760724
149LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36747038
150CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36242570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.19295641
2MP0005360_urolithiasis7.41671866
3MP0005085_abnormal_gallbladder_physiolo6.30499050
4MP0005365_abnormal_bile_salt6.10704286
5MP0008875_abnormal_xenobiotic_pharmacok4.97345197
6MP0003806_abnormal_nucleotide_metabolis4.15307008
7MP0003252_abnormal_bile_duct3.78703545
8MP0010329_abnormal_lipoprotein_level3.61029908
9MP0009840_abnormal_foam_cell3.17060061
10MP0005083_abnormal_biliary_tract3.16134033
11MP0003195_calcinosis3.04212416
12MP0005332_abnormal_amino_acid2.76924100
13MP0001666_abnormal_nutrient_absorption2.63526053
14MP0003191_abnormal_cellular_cholesterol2.26871177
15MP0004019_abnormal_vitamin_homeostasis2.19499232
16MP0000609_abnormal_liver_physiology2.18002546
17MP0002118_abnormal_lipid_homeostasis2.17718324
18MP0002138_abnormal_hepatobiliary_system1.97074885
19MP0003868_abnormal_feces_composition1.96186508
20MP0005319_abnormal_enzyme/_coenzyme1.82039273
21MP0001764_abnormal_homeostasis1.72195591
22MP0001986_abnormal_taste_sensitivity1.55536004
23MP0005584_abnormal_enzyme/coenzyme_acti1.53870643
24MP0009697_abnormal_copulation1.46818593
25MP0009643_abnormal_urine_homeostasis1.34781988
26MP0005451_abnormal_body_composition1.32878872
27MP0003011_delayed_dark_adaptation1.29418003
28MP0002254_reproductive_system_inflammat1.28860159
29MP0003186_abnormal_redox_activity1.25750684
30MP0003705_abnormal_hypodermis_morpholog1.20210959
31MP0005647_abnormal_sex_gland1.15991725
32MP0000598_abnormal_liver_morphology1.15769571
33MP0003656_abnormal_erythrocyte_physiolo1.11666612
34MP0002876_abnormal_thyroid_physiology1.11438877
35MP0005670_abnormal_white_adipose1.01416570
36MP0002132_abnormal_respiratory_system1.00923007
37MP0000604_amyloidosis0.99985042
38MP0009763_increased_sensitivity_to0.97738691
39MP0005636_abnormal_mineral_homeostasis0.96875275
40MP0009764_decreased_sensitivity_to0.95731612
41MP0002078_abnormal_glucose_homeostasis0.95729654
42MP0003879_abnormal_hair_cell0.93380105
43MP0005220_abnormal_exocrine_pancreas0.91601479
44MP0009642_abnormal_blood_homeostasis0.88679970
45MP0004130_abnormal_muscle_cell0.86786291
46MP0010368_abnormal_lymphatic_system0.86082509
47MP0008469_abnormal_protein_level0.85782028
48MP0006036_abnormal_mitochondrial_physio0.84626472
49MP0002971_abnormal_brown_adipose0.83902358
50MP0002282_abnormal_trachea_morphology0.83255426
51MP0005408_hypopigmentation0.81997215
52MP0005334_abnormal_fat_pad0.81160472
53MP0005376_homeostasis/metabolism_phenot0.78136049
54MP0005535_abnormal_body_temperature0.77857695
55MP0002249_abnormal_larynx_morphology0.75789843
56MP0001661_extended_life_span0.75478018
57MP0005084_abnormal_gallbladder_morpholo0.74104024
58MP0009765_abnormal_xenobiotic_induced0.73663471
59MP0001881_abnormal_mammary_gland0.71039291
60MP0001756_abnormal_urination0.69327642
61MP0005448_abnormal_energy_balance0.66367900
62MP0002837_dystrophic_cardiac_calcinosis0.64269461
63MP0003690_abnormal_glial_cell0.63930325
64MP0005266_abnormal_metabolism0.63137106
65MP0000639_abnormal_adrenal_gland0.62886842
66MP0003329_amyloid_beta_deposits0.57164090
67MP0005666_abnormal_adipose_tissue0.57145039
68MP0005187_abnormal_penis_morphology0.55394150
69MP0009053_abnormal_anal_canal0.53931454
70MP0002928_abnormal_bile_duct0.51966279
71MP0005395_other_phenotype0.51545324
72MP0003953_abnormal_hormone_level0.51384575
73MP0001915_intracranial_hemorrhage0.50684454
74MP0000003_abnormal_adipose_tissue0.48488871
75MP0004782_abnormal_surfactant_physiolog0.47298572
76MP0002136_abnormal_kidney_physiology0.47001356
77MP0010386_abnormal_urinary_bladder0.46682629
78MP0006035_abnormal_mitochondrial_morpho0.46586780
79MP0003638_abnormal_response/metabolism_0.46307476
80MP0003172_abnormal_lysosome_physiology0.44915604
81MP0009785_altered_susceptibility_to0.44785702
82MP0003718_maternal_effect0.44585306
83MP0002970_abnormal_white_adipose0.43592379
84MP0005464_abnormal_platelet_physiology0.42901293
85MP0009672_abnormal_birth_weight0.42091482
86MP0009115_abnormal_fat_cell0.42005329
87MP0001944_abnormal_pancreas_morphology0.41670286
88MP0008874_decreased_physiological_sensi0.40683058
89MP0003724_increased_susceptibility_to0.38681373
90MP0008873_increased_physiological_sensi0.38591647
91MP0002168_other_aberrant_phenotype0.38276189
92MP0004264_abnormal_extraembryonic_tissu0.38221648
93MP0000579_abnormal_nail_morphology0.38147367
94MP0003075_altered_response_to0.38092890
95MP0005248_abnormal_Harderian_gland0.37571796
96MP0002796_impaired_skin_barrier0.37336483
97MP0004043_abnormal_pH_regulation0.36962649
98MP0002822_catalepsy0.36902710
99MP0000230_abnormal_systemic_arterial0.36098977
100MP0003436_decreased_susceptibility_to0.35980714
101MP0003959_abnormal_lean_body0.35678638
102MP0005058_abnormal_lysosome_morphology0.32656314
103MP0005646_abnormal_pituitary_gland0.32324995
104MP0000371_diluted_coat_color0.31865872
105MP0008872_abnormal_physiological_respon0.30350406
106MP0000249_abnormal_blood_vessel0.30292054
107MP0009384_cardiac_valve_regurgitation0.29472436
108MP0001243_abnormal_dermal_layer0.29449771
109MP0006082_CNS_inflammation0.29411494
110MP0005166_decreased_susceptibility_to0.28707570
111MP0002060_abnormal_skin_morphology0.28542846
112MP0003300_gastrointestinal_ulcer0.28146734
113MP0004381_abnormal_hair_follicle0.28082898
114MP0000678_abnormal_parathyroid_gland0.28013080
115MP0002089_abnormal_postnatal_growth/wei0.27844192
116MP0000467_abnormal_esophagus_morphology0.25748329
117MP0005410_abnormal_fertilization0.25648458
118MP0002736_abnormal_nociception_after0.24766195
119MP0000013_abnormal_adipose_tissue0.24085414
120MP0005023_abnormal_wound_healing0.23873564
121MP0001502_abnormal_circadian_rhythm0.23763068
122MP0001968_abnormal_touch/_nociception0.22797084
123MP0001845_abnormal_inflammatory_respons0.22153772

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.42043360
2Deep venous thrombosis (HP:0002625)7.21224861
3Intrahepatic cholestasis (HP:0001406)7.16701212
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.47854443
5Prolonged partial thromboplastin time (HP:0003645)6.43978496
6Xanthomatosis (HP:0000991)6.16867890
7Hypobetalipoproteinemia (HP:0003563)6.16849445
8Hyperlipoproteinemia (HP:0010980)5.49554671
9Complement deficiency (HP:0004431)5.20120584
10Joint hemorrhage (HP:0005261)4.68840348
11Hypolipoproteinemia (HP:0010981)4.66449704
12Hyperammonemia (HP:0001987)4.54561025
13Ketosis (HP:0001946)4.48541913
14Hyperglycinemia (HP:0002154)4.47573841
15Epidermoid cyst (HP:0200040)4.46542302
16Abnormality of the common coagulation pathway (HP:0010990)4.37880399
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.28966841
18Hypoglycemic coma (HP:0001325)4.20991493
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.15619888
20Hypoalphalipoproteinemia (HP:0003233)4.12359737
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12140827
22Hyperglycinuria (HP:0003108)4.12106109
23Abnormality of methionine metabolism (HP:0010901)4.11664368
24Fat malabsorption (HP:0002630)4.06677883
25Abnormality of serine family amino acid metabolism (HP:0010894)4.02217131
26Abnormality of glycine metabolism (HP:0010895)4.02217131
27Abnormality of aspartate family amino acid metabolism (HP:0010899)4.00103221
28Abnormality of the intrinsic pathway (HP:0010989)3.96114004
29Abnormality of complement system (HP:0005339)3.77919950
30Conjugated hyperbilirubinemia (HP:0002908)3.66772643
31Abnormality of pyrimidine metabolism (HP:0004353)3.62584366
32Hypercholesterolemia (HP:0003124)3.55642611
33Nephritis (HP:0000123)3.50412650
34Ketoacidosis (HP:0001993)3.46001811
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.42271870
36Abnormality of fatty-acid metabolism (HP:0004359)3.38795614
37Hyperbilirubinemia (HP:0002904)3.27161058
38Abnormality of nucleobase metabolism (HP:0010932)3.16275090
39Delayed CNS myelination (HP:0002188)3.05413114
40Steatorrhea (HP:0002570)3.05310187
41Abnormality of serum amino acid levels (HP:0003112)3.03269232
42Hepatocellular carcinoma (HP:0001402)2.93469503
43Abnormality of purine metabolism (HP:0004352)2.93120452
44Myocardial infarction (HP:0001658)2.91684452
45Hypoglycemic seizures (HP:0002173)2.86857801
46Skin nodule (HP:0200036)2.84371386
47Hypochromic microcytic anemia (HP:0004840)2.82692079
48Metabolic acidosis (HP:0001942)2.76963357
49Fair hair (HP:0002286)2.76063112
50Gout (HP:0001997)2.71319152
51Spontaneous abortion (HP:0005268)2.69614989
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.65410923
53Dicarboxylic aciduria (HP:0003215)2.65410923
54Systemic lupus erythematosus (HP:0002725)2.63975183
55Lethargy (HP:0001254)2.60951122
56Vascular calcification (HP:0004934)2.53480693
57Hyperinsulinemic hypoglycemia (HP:0000825)2.49678456
58Purpura (HP:0000979)2.49642810
59Abnormal gallbladder morphology (HP:0012437)2.47645227
60Irritability (HP:0000737)2.42957256
61Osteomalacia (HP:0002749)2.39697432
62Acanthocytosis (HP:0001927)2.38812258
63Cholelithiasis (HP:0001081)2.37309475
64Mitral stenosis (HP:0001718)2.37103128
65Reduced antithrombin III activity (HP:0001976)2.37032968
66Late onset (HP:0003584)2.36547120
67Cerebral edema (HP:0002181)2.35933579
68Glomerulonephritis (HP:0000099)2.35616365
69Spastic diplegia (HP:0001264)2.32086453
70Neonatal hypoglycemia (HP:0001998)2.31015795
71Pulmonary embolism (HP:0002204)2.28479323
72Neonatal onset (HP:0003623)2.27353434
73Generalized aminoaciduria (HP:0002909)2.25352700
74Cardiovascular calcification (HP:0011915)2.24913364
75Pancreatitis (HP:0001733)2.21660872
76Malnutrition (HP:0004395)2.18657007
77Recurrent gram-negative bacterial infections (HP:0005420)2.17349150
78Brushfield spots (HP:0001088)2.16898903
79Esophageal varix (HP:0002040)2.16310085
80Amyloidosis (HP:0011034)2.15668807
81Cholecystitis (HP:0001082)2.14685773
82Abnormal gallbladder physiology (HP:0012438)2.14685773
83Enlarged kidneys (HP:0000105)2.13663673
84Hyperglycemia (HP:0003074)2.13210399
85Menorrhagia (HP:0000132)2.11868773
86Atrioventricular block (HP:0001678)2.11631146
87Vomiting (HP:0002013)2.08173110
88Opisthotonus (HP:0002179)2.07493622
89Sensorimotor neuropathy (HP:0007141)2.04570580
90Hemorrhage of the eye (HP:0011885)2.03530253
91Gingival bleeding (HP:0000225)2.02887708
92Symptomatic seizures (HP:0011145)2.02564680
93Abnormality of proline metabolism (HP:0010907)1.99247943
94Hydroxyprolinuria (HP:0003080)1.99247943
95Generalized hypopigmentation of hair (HP:0011358)1.98914011
96Abnormality of the gallbladder (HP:0005264)1.98704944
97Increased serum ferritin (HP:0003281)1.98340826
98Epistaxis (HP:0000421)1.98233087
99Thrombophlebitis (HP:0004418)1.93968403
100Rickets (HP:0002748)1.93361029
101Genetic anticipation (HP:0003743)1.89340896
102Abnormal enzyme/coenzyme activity (HP:0012379)1.89325328
103Hyperphosphaturia (HP:0003109)1.88909776
104Abnormality of transition element cation homeostasis (HP:0011030)1.88630641
105Poikilocytosis (HP:0004447)1.87995978
106Elevated alkaline phosphatase (HP:0003155)1.87594234
107Hypochromic anemia (HP:0001931)1.87042934
108Abnormal cartilage morphology (HP:0002763)1.86796665
109Alkalosis (HP:0001948)1.86716388
110Renal cortical cysts (HP:0000803)1.84053931
111Abnormality of iron homeostasis (HP:0011031)1.83970566
112Dysmetric saccades (HP:0000641)1.82535528
113Abnormality of the Achilles tendon (HP:0005109)1.82472323
114Gangrene (HP:0100758)1.81984871
115Hyperuricemia (HP:0002149)1.81466503
116Increased purine levels (HP:0004368)1.81466503
117Elevated hepatic transaminases (HP:0002910)1.81063914
118Urinary glycosaminoglycan excretion (HP:0003541)1.77934211
119Mucopolysacchariduria (HP:0008155)1.77934211
120Hypophosphatemic rickets (HP:0004912)1.77831084
121Arthropathy (HP:0003040)1.76700104
122Glycosuria (HP:0003076)1.76103504
123Abnormality of urine glucose concentration (HP:0011016)1.76103504
124Abnormal urine phosphate concentration (HP:0012599)1.73803259
125Abnormality of alkaline phosphatase activity (HP:0004379)1.71945931
126Abnormality of polysaccharide metabolism (HP:0011012)1.68745370
127Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68745370
128Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68745370
129Blue irides (HP:0000635)1.65542082
130Abnormality of the hepatic vasculature (HP:0006707)1.64912012
131Hypophosphatemia (HP:0002148)1.60890905
132Cerebral palsy (HP:0100021)1.53131186
133Abnormal biliary tract physiology (HP:0012439)1.52640505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.94795563
2CDK194.97208730
3SIK14.84066765
4ERN14.36156603
5FGFR44.33806782
6INSRR3.86206392
7TNK23.07786636
8TAOK33.02560282
9OXSR12.89793819
10ERBB42.56388001
11PKN22.35294669
12TRIB32.32968221
13FLT32.05965499
14MST1R1.91367925
15MAP2K41.90327635
16PIK3CG1.84259339
17NTRK31.74683951
18MAPK111.71365322
19FRK1.70193029
20PTK61.66303531
21LATS11.60442089
22TYK21.53083477
23DAPK21.48851350
24PRPF4B1.45533918
25BLK1.45392000
26MAPK151.44038643
27MUSK1.36716479
28CAMK1D1.30453931
29PRKAA21.25545010
30JAK21.24459388
31NEK91.20639139
32ABL21.15656129
33FGFR21.13506905
34EPHA31.13100666
35STK38L1.07722230
36MAP3K71.07377183
37KDR1.06909425
38PINK11.06297535
39WNK41.05582319
40JAK11.00553791
41MET0.97095662
42TBK10.96864236
43EPHB10.96525410
44DYRK1B0.93474600
45IRAK30.92190723
46MAP3K140.91546945
47MAP3K100.91423790
48MAP3K30.88497497
49CAMKK10.83744477
50ERBB20.83341439
51MAP2K30.83322271
52ADRBK20.81962302
53RIPK10.80084901
54PRKCZ0.79662129
55GRK60.78688254
56TIE10.78089668
57PRKAA10.77791958
58SIK20.76845456
59MAPK40.75250782
60PTK20.72610825
61PRKACG0.72517857
62STK110.71707614
63CSNK1D0.70436898
64SMG10.70265940
65TLK10.69899177
66PRKG10.69794639
67GSK3A0.69680218
68HIPK20.69404256
69CAMK1G0.69145590
70FGFR30.67411514
71CDK60.66510848
72PRKACA0.65689292
73STK380.63643734
74CSK0.62687461
75MAPK120.62374110
76TGFBR20.58662065
77TXK0.57011325
78CAMK2G0.56141764
79RET0.54918017
80SGK30.52285545
81PDPK10.51425381
82MAP2K60.50794141
83IRAK10.50201270
84MAP3K110.50190166
85PDK40.48970099
86PDK30.48970099
87ACVR1B0.46936125
88IGF1R0.46297375
89MAPK70.45214492
90IKBKE0.44326833
91MTOR0.44182739
92MAP3K20.43766345
93MAP4K10.41999237
94MAP3K10.40920732
95BMX0.39997379
96MAPK30.39497867
97MAP2K10.39178166
98GRK10.38956270
99PRKCQ0.38896615
100SGK20.38048999
101EPHA20.37989013
102RPS6KA30.37935071
103CSF1R0.37809617
104SGK10.37652799
105MARK20.35827993
106PDK20.35444681
107PDGFRA0.35026260
108PIK3CA0.34266303
109MAP2K20.33944707
110CSNK1G10.33941949
111CAMKK20.31382472
112SRC0.31061945
113IKBKB0.30998650
114SGK4940.30843867
115SGK2230.30843867
116MAP3K60.30532611
117PDK10.29866508
118EPHA40.29747756
119MAPKAPK30.29430483
120BMPR1B0.28976627
121KSR20.28479144
122CDK40.28248066
123PRKCG0.28121956
124EGFR0.27986077
125ICK0.27186566
126MAP3K50.26115334
127AKT30.26002348
128PKN10.25948924
129TAOK20.25519829
130CHUK0.25449495
131FER0.23761311
132CAMK40.23663913
133ZAP700.23531978
134IRAK20.23465725
135PRKCA0.22554863
136MAP3K130.21939035

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.40008811
2Nitrogen metabolism_Homo sapiens_hsa009103.47256084
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29844289
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26781539
5Arginine biosynthesis_Homo sapiens_hsa002202.98800454
6Tryptophan metabolism_Homo sapiens_hsa003802.69595547
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66613585
8Complement and coagulation cascades_Homo sapiens_hsa046102.65686339
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63064737
10Fatty acid degradation_Homo sapiens_hsa000712.50022122
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46952968
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46821288
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22182346
14Butanoate metabolism_Homo sapiens_hsa006502.17474133
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09017066
16Peroxisome_Homo sapiens_hsa041462.07770473
17Propanoate metabolism_Homo sapiens_hsa006402.00927252
18Caffeine metabolism_Homo sapiens_hsa002321.94735681
19Histidine metabolism_Homo sapiens_hsa003401.91569881
20PPAR signaling pathway_Homo sapiens_hsa033201.91013701
21Chemical carcinogenesis_Homo sapiens_hsa052041.89308862
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.88781886
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86942341
24Fatty acid metabolism_Homo sapiens_hsa012121.86889764
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.77908311
26beta-Alanine metabolism_Homo sapiens_hsa004101.70838519
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69406978
28Staphylococcus aureus infection_Homo sapiens_hsa051501.68340185
29Selenocompound metabolism_Homo sapiens_hsa004501.65766477
30Retinol metabolism_Homo sapiens_hsa008301.64195916
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60222651
32Phenylalanine metabolism_Homo sapiens_hsa003601.60128120
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57562207
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52921014
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49744720
36Sulfur metabolism_Homo sapiens_hsa009201.49398999
37Bile secretion_Homo sapiens_hsa049761.45996737
38Tyrosine metabolism_Homo sapiens_hsa003501.45285723
39Pyruvate metabolism_Homo sapiens_hsa006201.41741802
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.41411091
41Fatty acid elongation_Homo sapiens_hsa000621.31823946
42Starch and sucrose metabolism_Homo sapiens_hsa005001.28907627
43Folate biosynthesis_Homo sapiens_hsa007901.27966383
44Fat digestion and absorption_Homo sapiens_hsa049751.22772514
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.22604021
46ABC transporters_Homo sapiens_hsa020101.20648964
47Steroid biosynthesis_Homo sapiens_hsa001001.17565356
48Biosynthesis of amino acids_Homo sapiens_hsa012301.16109067
49Carbon metabolism_Homo sapiens_hsa012001.11932044
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04075352
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.03553155
52Sulfur relay system_Homo sapiens_hsa041220.95746425
53Arginine and proline metabolism_Homo sapiens_hsa003300.94628181
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92164837
55Vitamin B6 metabolism_Homo sapiens_hsa007500.87378352
56Vitamin digestion and absorption_Homo sapiens_hsa049770.86093558
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83205536
58Lysine degradation_Homo sapiens_hsa003100.81889250
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79072878
60Fatty acid biosynthesis_Homo sapiens_hsa000610.78353892
61Glycerolipid metabolism_Homo sapiens_hsa005610.74530378
62One carbon pool by folate_Homo sapiens_hsa006700.69865087
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69127485
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60140726
65Glutathione metabolism_Homo sapiens_hsa004800.59794177
66Pentose phosphate pathway_Homo sapiens_hsa000300.55379594
67Metabolic pathways_Homo sapiens_hsa011000.46344766
68Pertussis_Homo sapiens_hsa051330.40434890
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39328488
70Galactose metabolism_Homo sapiens_hsa000520.37968013
71Prion diseases_Homo sapiens_hsa050200.34650232
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31615870
73Insulin resistance_Homo sapiens_hsa049310.31116096
74Linoleic acid metabolism_Homo sapiens_hsa005910.29045053
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.27955917
76Fructose and mannose metabolism_Homo sapiens_hsa000510.26859936
77Other glycan degradation_Homo sapiens_hsa005110.18146764
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.17431274
79Glucagon signaling pathway_Homo sapiens_hsa049220.15754675
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14404477
81AMPK signaling pathway_Homo sapiens_hsa041520.08986293
82Mineral absorption_Homo sapiens_hsa049780.03028775
83Amoebiasis_Homo sapiens_hsa051460.00227036
84Serotonergic synapse_Homo sapiens_hsa047260.00159677
85Lysosome_Homo sapiens_hsa04142-0.2094243
86Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1970879
87Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1965793
88African trypanosomiasis_Homo sapiens_hsa05143-0.1937377
89Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1923810
90Renin-angiotensin system_Homo sapiens_hsa04614-0.1798025
91Hepatitis C_Homo sapiens_hsa05160-0.1772964
92Type II diabetes mellitus_Homo sapiens_hsa04930-0.1764595
93Ether lipid metabolism_Homo sapiens_hsa00565-0.1574529
94Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1544501
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1542771
96N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1528043
97Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1458045
98Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1441346
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1354402
100Regulation of autophagy_Homo sapiens_hsa04140-0.1035570
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.1020126
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0944616
103Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0725998
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0646493
105Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0636001
106Insulin signaling pathway_Homo sapiens_hsa04910-0.0483874
107Sphingolipid metabolism_Homo sapiens_hsa00600-0.0385995
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0338646
109Circadian rhythm_Homo sapiens_hsa04710-0.0334641
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0225394
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0198040

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