IGFBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.44789986
2L-phenylalanine catabolic process (GO:0006559)7.44789986
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.20908712
4L-phenylalanine metabolic process (GO:0006558)7.20908712
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.94120779
6intestinal cholesterol absorption (GO:0030299)6.80889328
7negative regulation of fibrinolysis (GO:0051918)6.73655380
8regulation of apoptotic cell clearance (GO:2000425)6.53296574
9high-density lipoprotein particle remodeling (GO:0034375)6.43932567
10regulation of fibrinolysis (GO:0051917)6.39847620
11glyoxylate metabolic process (GO:0046487)6.32533416
12aromatic amino acid family catabolic process (GO:0009074)6.31461443
13regulation of cholesterol esterification (GO:0010872)5.93543131
14reverse cholesterol transport (GO:0043691)5.93407697
15urea metabolic process (GO:0019627)5.81173280
16urea cycle (GO:0000050)5.81173280
17plasma lipoprotein particle remodeling (GO:0034369)5.64637221
18protein-lipid complex remodeling (GO:0034368)5.64637221
19macromolecular complex remodeling (GO:0034367)5.64637221
20protein carboxylation (GO:0018214)5.49636692
21peptidyl-glutamic acid carboxylation (GO:0017187)5.49636692
22regulation of protein activation cascade (GO:2000257)5.49243312
23regulation of triglyceride catabolic process (GO:0010896)5.43382146
24kynurenine metabolic process (GO:0070189)5.37587866
25tryptophan catabolic process (GO:0006569)5.37177143
26indole-containing compound catabolic process (GO:0042436)5.37177143
27indolalkylamine catabolic process (GO:0046218)5.37177143
28cysteine metabolic process (GO:0006534)5.36238544
29phospholipid efflux (GO:0033700)5.35161897
30nitrogen cycle metabolic process (GO:0071941)5.32205579
31sulfur amino acid catabolic process (GO:0000098)5.29100908
32complement activation, alternative pathway (GO:0006957)5.15001542
33bile acid biosynthetic process (GO:0006699)5.14653002
34tryptophan metabolic process (GO:0006568)5.08320046
35plasma lipoprotein particle clearance (GO:0034381)5.08275357
36regulation of complement activation (GO:0030449)4.97537559
37alpha-linolenic acid metabolic process (GO:0036109)4.93518001
38serine family amino acid catabolic process (GO:0009071)4.93506879
39triglyceride homeostasis (GO:0070328)4.91232312
40acylglycerol homeostasis (GO:0055090)4.91232312
41tyrosine metabolic process (GO:0006570)4.86466855
42cholesterol efflux (GO:0033344)4.80887325
43plasma lipoprotein particle assembly (GO:0034377)4.73212887
44blood coagulation, intrinsic pathway (GO:0007597)4.72907827
45acute-phase response (GO:0006953)4.71607673
46regulation of cholesterol homeostasis (GO:2000188)4.71176724
47fibrinolysis (GO:0042730)4.68349967
48homocysteine metabolic process (GO:0050667)4.66082865
49intestinal absorption (GO:0050892)4.63203046
50aromatic amino acid family metabolic process (GO:0009072)4.59320986
51negative regulation of sterol transport (GO:0032372)4.48979340
52negative regulation of cholesterol transport (GO:0032375)4.48979340
53positive regulation of triglyceride lipase activity (GO:0061365)4.48438029
54positive regulation of lipoprotein lipase activity (GO:0051006)4.48438029
55bile acid metabolic process (GO:0008206)4.45411137
56amino-acid betaine metabolic process (GO:0006577)4.42870454
57heme transport (GO:0015886)4.41021612
58cellular ketone body metabolic process (GO:0046950)4.37439111
59negative regulation of lipase activity (GO:0060192)4.34813368
60alpha-amino acid catabolic process (GO:1901606)4.33404038
61plasma lipoprotein particle organization (GO:0071827)4.32888209
62negative regulation of complement activation (GO:0045916)4.31275317
63fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.29741174
64arginine metabolic process (GO:0006525)4.28389554
65proline metabolic process (GO:0006560)4.27658050
66regulation of bile acid biosynthetic process (GO:0070857)4.26390187
67regulation of plasminogen activation (GO:0010755)4.26256623
68protein-lipid complex assembly (GO:0065005)4.24219918
69glutamate metabolic process (GO:0006536)4.21047786
70negative regulation of protein activation cascade (GO:2000258)4.19664147
71aldehyde catabolic process (GO:0046185)4.19555860
72regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.19317937
73phospholipid homeostasis (GO:0055091)4.15832831
74positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.14562118
75regulation of cholesterol biosynthetic process (GO:0045540)4.14044403
76low-density lipoprotein particle remodeling (GO:0034374)4.13974679
77regulation of humoral immune response (GO:0002920)4.12829945
78positive regulation of extracellular matrix organization (GO:1903055)4.12161028
79low-density lipoprotein particle clearance (GO:0034383)4.09596701
80lysine catabolic process (GO:0006554)4.09238747
81lysine metabolic process (GO:0006553)4.09238747
82glycine metabolic process (GO:0006544)4.09099927
83protein-lipid complex subunit organization (GO:0071825)4.07042271
84cellular modified amino acid catabolic process (GO:0042219)4.05073257
85positive regulation of lipid catabolic process (GO:0050996)4.03199618
86positive regulation of hemostasis (GO:1900048)4.00059037
87positive regulation of blood coagulation (GO:0030194)4.00059037
88cellular amino acid catabolic process (GO:0009063)3.98801902
89sterol transport (GO:0015918)3.96318555
90cholesterol transport (GO:0030301)3.96318555
91dicarboxylic acid biosynthetic process (GO:0043650)3.96077240
92cholesterol homeostasis (GO:0042632)3.93219805
93protein activation cascade (GO:0072376)3.91873876
94serine family amino acid metabolic process (GO:0009069)3.91220675
95lipoprotein metabolic process (GO:0042157)3.89178100
96serine family amino acid biosynthetic process (GO:0009070)3.88672828
97sterol homeostasis (GO:0055092)3.86501568
98diacylglycerol metabolic process (GO:0046339)3.86462019
99lung epithelium development (GO:0060428)3.81762739
100positive regulation of steroid metabolic process (GO:0045940)3.80814651
101indolalkylamine metabolic process (GO:0006586)3.78053759
102ketone body metabolic process (GO:1902224)3.77279414
103bile acid and bile salt transport (GO:0015721)3.73092558
104imidazole-containing compound metabolic process (GO:0052803)3.72574167
105coenzyme catabolic process (GO:0009109)3.70037001
106cofactor catabolic process (GO:0051187)3.69855654
107amine catabolic process (GO:0009310)3.67181349
108cellular biogenic amine catabolic process (GO:0042402)3.67181349
109very-low-density lipoprotein particle assembly (GO:0034379)3.67038283
110benzene-containing compound metabolic process (GO:0042537)3.65224572
111proline biosynthetic process (GO:0006561)3.62510678
112positive regulation of coagulation (GO:0050820)3.61914160
113negative regulation of blood coagulation (GO:0030195)3.61201993
114negative regulation of hemostasis (GO:1900047)3.61201993
115embryonic retina morphogenesis in camera-type eye (GO:0060059)3.55182893
116positive regulation of hormone metabolic process (GO:0032352)3.54181161
117complement activation (GO:0006956)3.54116646
118complement activation, classical pathway (GO:0006958)3.52557508
119opsonization (GO:0008228)3.52276382
120positive regulation of fatty acid beta-oxidation (GO:0032000)3.50253690
121negative regulation of coagulation (GO:0050819)3.47601143
122carboxylic acid catabolic process (GO:0046395)3.47130923
123organic acid catabolic process (GO:0016054)3.47130923
124positive regulation of fatty acid biosynthetic process (GO:0045723)3.46816939
125pinocytosis (GO:0006907)3.31684294
126cytolysis (GO:0019835)3.30619791
127negative regulation of sodium ion transport (GO:0010766)3.29159332
128negative regulation of humoral immune response (GO:0002921)3.28630435
129negative regulation of wound healing (GO:0061045)3.26769622
130regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.26385921
131regulation of extracellular matrix organization (GO:1903053)3.25223190
132peptidyl-glutamic acid modification (GO:0018200)3.24947679
133lipid homeostasis (GO:0055088)3.23533491
134positive regulation of hormone biosynthetic process (GO:0046886)3.13033131
135nephron tubule morphogenesis (GO:0072078)3.12598058
136nephron epithelium morphogenesis (GO:0072088)3.12598058
137regulation of cholesterol metabolic process (GO:0090181)3.10946741
138renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.10285718
139modified amino acid transport (GO:0072337)3.05050031
140acute inflammatory response (GO:0002526)3.03907156
141negative regulation of norepinephrine secretion (GO:0010700)3.00307644
142negative regulation of digestive system process (GO:0060457)2.98978130
1434-hydroxyproline metabolic process (GO:0019471)2.98227781
144acylglycerol catabolic process (GO:0046464)2.97323536
145neutral lipid catabolic process (GO:0046461)2.97323536
146regulation of norepinephrine secretion (GO:0014061)2.96268246

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.23204159
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.00735021
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.56531848
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.30760811
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.51870673
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.28487326
7* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.22635659
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.12633158
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97654454
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.87710495
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79420423
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.69769278
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.13881577
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.06487354
15* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04014037
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02930630
17* ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.2406409
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88186953
19AR_21909140_ChIP-Seq_LNCAP_Human1.87483019
20GATA1_22025678_ChIP-Seq_K562_Human1.79364619
21TCF4_18268006_ChIP-ChIP_LS174T_Human1.78478604
22CLOCK_20551151_ChIP-Seq_293T_Human1.76842248
23PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.69224761
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.67696454
25* FOXA2_19822575_ChIP-Seq_HepG2_Human1.64015917
26* HNF4A_19822575_ChIP-Seq_HepG2_Human1.38175822
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30943197
28HTT_18923047_ChIP-ChIP_STHdh_Human1.27559328
29NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24463395
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18670626
31RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16134155
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12702323
33CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10600105
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08806406
35POU5F1_16518401_ChIP-PET_MESCs_Mouse1.08189926
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07953475
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04725316
38AR_21572438_ChIP-Seq_LNCaP_Human1.03050321
39ZNF263_19887448_ChIP-Seq_K562_Human1.01019037
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96920379
41NANOG_21062744_ChIP-ChIP_HESCs_Human0.96550237
42RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94688204
43ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94455210
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93973176
45TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92705303
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91721658
47IRF8_22096565_ChIP-ChIP_GC-B_Human0.90643687
48TP53_22127205_ChIP-Seq_IMR90_Human0.89274614
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88776902
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87929140
51ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86804124
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86408057
53SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86283890
54TRIM28_21343339_ChIP-Seq_HEK293_Human0.85974288
55DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84785478
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83271937
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83201274
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83033425
59ATF3_27146783_Chip-Seq_COLON_Human0.82334947
60HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81214963
61SOX17_20123909_ChIP-Seq_XEN_Mouse0.79329993
62AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79039701
63* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78631621
64* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76799195
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76520733
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.76224441
67GATA4_25053715_ChIP-Seq_YYC3_Human0.75050195
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.74404483
69* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74261768
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74169808
71GATA1_19941826_ChIP-Seq_K562_Human0.73700977
72LXR_22292898_ChIP-Seq_THP-1_Human0.73458101
73SMC4_20622854_ChIP-Seq_HELA_Human0.72968546
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72195611
75RARA_24833708_ChIP-Seq_LIVER_Mouse0.72176429
76SOX11_22085726_ChIP-Seq_ESNs_Mouse0.70663715
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.70361898
78* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69665728
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69622362
80ESR2_21235772_ChIP-Seq_MCF-7_Human0.69235203
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.69051073
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69020256
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.67465888
84SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67353118
85KDM2B_26808549_Chip-Seq_K562_Human0.67163664
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.66854967
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.66157651
88EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.66118218
89NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.64777086
90ZFX_18555785_ChIP-Seq_MESCs_Mouse0.63704083
91SPI1_26923725_Chip-Seq_HPCs_Mouse0.63583763
92KAP1_27257070_Chip-Seq_ESCs_Mouse0.63478869
93GATA1_19941827_ChIP-Seq_MEL_Mouse0.62230937
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.61921532
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.61576729
96EGR1_19032775_ChIP-ChIP_M12_Human0.60901207
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.60102964
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.59851078
99GATA2_19941826_ChIP-Seq_K562_Human0.58996915
100* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58598831
101RARB_24833708_ChIP-Seq_LIVER_Mouse0.57166264
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.56379613
103BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.56086157
104CEBPB_22108803_ChIP-Seq_LS180_Human0.53887613
105ESR1_21235772_ChIP-Seq_MCF-7_Human0.52929009
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.52638924
107FOXA1_25552417_ChIP-Seq_VCAP_Human0.50497245
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.50188599
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.50188599
110* AR_20517297_ChIP-Seq_VCAP_Human0.49185362
111SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48411887
112MYC_19915707_ChIP-ChIP_AK7_Human0.47984305
113FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.47884982
114KAP1_22055183_ChIP-Seq_ESCs_Mouse0.46430484
115P53_21459846_ChIP-Seq_SAOS-2_Human0.45515225
116MYC_27129775_Chip-Seq_CORNEA_Mouse0.45069518
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.44046932
118FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.43745261
119GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.43670301
120* TAF2_19829295_ChIP-Seq_ESCs_Human0.43664163
121FOXO3_23340844_ChIP-Seq_DLD1_Human0.42837934
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42809017
123BCOR_27268052_Chip-Seq_Bcells_Human0.42728490
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.42622112
125PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41440988
126GATA6_25053715_ChIP-Seq_YYC3_Human0.41306715
127EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.41281477
128PPAR_26484153_Chip-Seq_NCI-H1993_Human0.41008719
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.40451155
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.40366707
131RACK7_27058665_Chip-Seq_MCF-7_Human0.38842095
132TET1_21451524_ChIP-Seq_MESCs_Mouse0.38772355
133CBP_21632823_ChIP-Seq_H3396_Human0.38402538
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.37696439
135SOX2_20726797_ChIP-Seq_SW620_Human0.37647275
136PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.37576839
137CTCF_27219007_Chip-Seq_Bcells_Human0.37274755
138CDX2_20551321_ChIP-Seq_CACO-2_Human0.36890901
139PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.36018060
140TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.35647502
141STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.35270573
142OCT4_20526341_ChIP-Seq_ESCs_Human0.35261244
143* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.35059920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.51462400
2MP0005360_urolithiasis7.35540881
3MP0005085_abnormal_gallbladder_physiolo6.11942279
4MP0005365_abnormal_bile_salt5.97764209
5MP0003122_maternal_imprinting5.84107258
6MP0008875_abnormal_xenobiotic_pharmacok4.59413966
7MP0009840_abnormal_foam_cell3.96720495
8MP0003191_abnormal_cellular_cholesterol3.85040354
9MP0010329_abnormal_lipoprotein_level3.80013024
10MP0003252_abnormal_bile_duct3.59183053
11MP0003806_abnormal_nucleotide_metabolis3.50068750
12MP0003123_paternal_imprinting3.40660156
13MP0005083_abnormal_biliary_tract3.15747318
14MP0000566_synostosis3.07959492
15MP0003195_calcinosis2.88390359
16MP0005332_abnormal_amino_acid2.82948310
17MP0001666_abnormal_nutrient_absorption2.53334222
18MP0002089_abnormal_postnatal_growth/wei2.33802948
19MP0002138_abnormal_hepatobiliary_system2.22371293
20MP0003172_abnormal_lysosome_physiology2.21860262
21* MP0000609_abnormal_liver_physiology2.20389693
22MP0004019_abnormal_vitamin_homeostasis2.15784710
23MP0002118_abnormal_lipid_homeostasis2.11064813
24MP0003011_delayed_dark_adaptation2.05331996
25MP0003121_genomic_imprinting1.99005320
26MP0003868_abnormal_feces_composition1.92777414
27MP0003656_abnormal_erythrocyte_physiolo1.91890152
28MP0006054_spinal_hemorrhage1.90361990
29MP0005319_abnormal_enzyme/_coenzyme1.78932834
30MP0001764_abnormal_homeostasis1.67507846
31MP0002132_abnormal_respiratory_system1.61722632
32MP0005584_abnormal_enzyme/coenzyme_acti1.61552910
33MP0005409_darkened_coat_color1.56130267
34MP0005257_abnormal_intraocular_pressure1.52855010
35MP0000604_amyloidosis1.45928323
36MP0009780_abnormal_chondrocyte_physiolo1.44928540
37MP0005451_abnormal_body_composition1.41290152
38MP0009697_abnormal_copulation1.37229944
39MP0004272_abnormal_basement_membrane1.35011153
40MP0009643_abnormal_urine_homeostasis1.30460588
41MP0003950_abnormal_plasma_membrane1.30080502
42MP0002254_reproductive_system_inflammat1.28725146
43MP0003705_abnormal_hypodermis_morpholog1.27848809
44MP0003186_abnormal_redox_activity1.27062363
45MP0003567_abnormal_fetal_cardiomyocyte1.26902500
46* MP0000598_abnormal_liver_morphology1.26055061
47MP0010368_abnormal_lymphatic_system1.24321578
48MP0003315_abnormal_perineum_morphology1.23568455
49MP0002933_joint_inflammation1.17346064
50MP0009763_increased_sensitivity_to1.12840170
51MP0005636_abnormal_mineral_homeostasis1.11559994
52MP0005076_abnormal_cell_differentiation1.10589772
53MP0009764_decreased_sensitivity_to1.07842268
54MP0005670_abnormal_white_adipose1.05414943
55MP0004264_abnormal_extraembryonic_tissu1.03388882
56MP0002938_white_spotting0.99204286
57MP0008469_abnormal_protein_level0.98367085
58MP0009642_abnormal_blood_homeostasis0.95199252
59MP0003566_abnormal_cell_adhesion0.92768451
60MP0003183_abnormal_peptide_metabolism0.92083982
61MP0003942_abnormal_urinary_system0.91716576
62MP0005464_abnormal_platelet_physiology0.91364910
63MP0003115_abnormal_respiratory_system0.89772525
64MP0008438_abnormal_cutaneous_collagen0.86886988
65MP0005376_homeostasis/metabolism_phenot0.86790784
66MP0001270_distended_abdomen0.86273470
67MP0005647_abnormal_sex_gland0.86204582
68MP0000003_abnormal_adipose_tissue0.82655400
69MP0009765_abnormal_xenobiotic_induced0.82275360
70MP0002078_abnormal_glucose_homeostasis0.81441811
71MP0003943_abnormal_hepatobiliary_system0.79281915
72MP0006036_abnormal_mitochondrial_physio0.77260111
73MP0000639_abnormal_adrenal_gland0.76665644
74MP0001756_abnormal_urination0.75975846
75MP0005220_abnormal_exocrine_pancreas0.75280306
76MP0002971_abnormal_brown_adipose0.75118284
77MP0005408_hypopigmentation0.73459512
78MP0009053_abnormal_anal_canal0.73035188
79MP0003690_abnormal_glial_cell0.72713925
80MP0005084_abnormal_gallbladder_morpholo0.71561616
81MP0005377_hearing/vestibular/ear_phenot0.70499292
82MP0003878_abnormal_ear_physiology0.70499292
83MP0000920_abnormal_myelination0.70123116
84MP0004883_abnormal_blood_vessel0.69984967
85MP0003879_abnormal_hair_cell0.69080702
86MP0003632_abnormal_nervous_system0.68500083
87MP0008260_abnormal_autophagy0.68405150
88MP0002909_abnormal_adrenal_gland0.65732851
89MP0004130_abnormal_muscle_cell0.65718794
90MP0003329_amyloid_beta_deposits0.64061345
91MP0001661_extended_life_span0.63608321
92MP0001324_abnormal_eye_pigmentation0.63032642
93MP0005334_abnormal_fat_pad0.62433822
94MP0005410_abnormal_fertilization0.61571085
95MP0002092_abnormal_eye_morphology0.60959786
96MP0003890_abnormal_embryonic-extraembry0.59307722
97MP0005535_abnormal_body_temperature0.58891800
98MP0005448_abnormal_energy_balance0.58189522
99MP0005395_other_phenotype0.58135588
100MP0005379_endocrine/exocrine_gland_phen0.56729547
101MP0003075_altered_response_to0.56658082
102MP0003436_decreased_susceptibility_to0.55936262
103MP0002136_abnormal_kidney_physiology0.55602532
104MP0000858_altered_metastatic_potential0.55276873
105MP0005266_abnormal_metabolism0.54898958
106MP0005164_abnormal_response_to0.54189531
107MP0004147_increased_porphyrin_level0.54079748
108MP0002876_abnormal_thyroid_physiology0.53151115
109MP0005666_abnormal_adipose_tissue0.52973887
110MP0001286_abnormal_eye_development0.51579275
111MP0002282_abnormal_trachea_morphology0.51523130
112MP0008873_increased_physiological_sensi0.51127423
113MP0003638_abnormal_response/metabolism_0.50258795
114MP0002160_abnormal_reproductive_system0.49437650
115MP0006292_abnormal_olfactory_placode0.49353033
116MP0002086_abnormal_extraembryonic_tissu0.49268165
117MP0000371_diluted_coat_color0.48252660
118MP0000678_abnormal_parathyroid_gland0.48048773
119MP0002233_abnormal_nose_morphology0.47212709
120MP0003724_increased_susceptibility_to0.46957168
121MP0000249_abnormal_blood_vessel0.46722468
122MP0001730_embryonic_growth_arrest0.46574645
123MP0000767_abnormal_smooth_muscle0.46131211
124MP0005023_abnormal_wound_healing0.45654344
125MP0005166_decreased_susceptibility_to0.44583244
126MP0005167_abnormal_blood-brain_barrier0.42784463
127MP0006035_abnormal_mitochondrial_morpho0.41192033
128MP0008874_decreased_physiological_sensi0.39573973
129MP0001243_abnormal_dermal_layer0.39064799
130MP0003953_abnormal_hormone_level0.38707071
131MP0003718_maternal_effect0.37937538
132MP0002837_dystrophic_cardiac_calcinosis0.37861080
133MP0009384_cardiac_valve_regurgitation0.37813713
134MP0008872_abnormal_physiological_respon0.37699270
135MP0002796_impaired_skin_barrier0.36931231
136MP0005058_abnormal_lysosome_morphology0.35490656
137MP0000230_abnormal_systemic_arterial0.35066816
138* MP0001845_abnormal_inflammatory_respons0.34731411
139MP0002928_abnormal_bile_duct0.33785958
140MP0003300_gastrointestinal_ulcer0.33714401
141MP0002135_abnormal_kidney_morphology0.33379812
142MP0009115_abnormal_fat_cell0.33007222
143MP0002168_other_aberrant_phenotype0.32321584
144MP0009672_abnormal_birth_weight0.31804013
145MP0001915_intracranial_hemorrhage0.30832483
146MP0001881_abnormal_mammary_gland0.30194133
147MP0002970_abnormal_white_adipose0.29655593
148MP0002822_catalepsy0.29412630
149MP0003453_abnormal_keratinocyte_physiol0.29379586
150MP0000579_abnormal_nail_morphology0.27833836

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.59609310
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.30434907
3Prolonged partial thromboplastin time (HP:0003645)6.85977663
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.60613819
5Intrahepatic cholestasis (HP:0001406)6.48588634
6Xanthomatosis (HP:0000991)6.47869189
7Hypobetalipoproteinemia (HP:0003563)6.03900202
8Hyperlipoproteinemia (HP:0010980)5.60162018
9Joint hemorrhage (HP:0005261)5.24109247
10Abnormality of the common coagulation pathway (HP:0010990)5.23981191
11Hypolipoproteinemia (HP:0010981)5.23540243
12Hypoalphalipoproteinemia (HP:0003233)5.22765920
13Complement deficiency (HP:0004431)5.20476987
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.71309074
15Small epiphyses (HP:0010585)4.66214426
16Abnormality of methionine metabolism (HP:0010901)4.61517324
17Hyperammonemia (HP:0001987)4.56998951
18Spontaneous abortion (HP:0005268)4.31583165
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.28064231
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.25988061
21Ketosis (HP:0001946)4.15813386
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.10681977
23Epidermoid cyst (HP:0200040)4.03024767
24Abnormality of the intrinsic pathway (HP:0010989)3.90674332
25Abnormality of carpal bone ossification (HP:0006257)3.86474379
26Abnormality of complement system (HP:0005339)3.84089648
27Abnormality of pyrimidine metabolism (HP:0004353)3.80727032
28Hypoglycemic coma (HP:0001325)3.69935869
29Hyperglycinemia (HP:0002154)3.58334024
30Abnormal tarsal ossification (HP:0008369)3.52577041
31Broad alveolar ridges (HP:0000187)3.49732997
32Fat malabsorption (HP:0002630)3.46449620
33Flat acetabular roof (HP:0003180)3.40591945
34Amyloidosis (HP:0011034)3.39548883
35Hepatocellular carcinoma (HP:0001402)3.37043349
36Hypercholesterolemia (HP:0003124)3.36384029
37Hyperglycinuria (HP:0003108)3.31553382
38Abnormality of glycine metabolism (HP:0010895)3.30230127
39Abnormality of serine family amino acid metabolism (HP:0010894)3.30230127
40Hyperbilirubinemia (HP:0002904)3.29745030
41Hypoplasia of the capital femoral epiphysis (HP:0003090)3.27214391
42Hypochromic microcytic anemia (HP:0004840)3.25629289
43Gingival bleeding (HP:0000225)3.16483021
44Purpura (HP:0000979)3.11840782
45Epiphyseal dysplasia (HP:0002656)3.11631245
46Abnormality of fatty-acid metabolism (HP:0004359)3.11464196
47Pancreatic islet-cell hyperplasia (HP:0004510)3.06919432
48Broad palm (HP:0001169)3.06028564
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.04861508
50Abnormality of nucleobase metabolism (HP:0010932)3.01162055
51Asymmetry of the thorax (HP:0001555)2.98383335
52Gout (HP:0001997)2.97220526
53Abnormal ossification of hand bones (HP:0005921)2.90076554
54Abnormal hand bone ossification (HP:0010660)2.87098730
55Glomerulonephritis (HP:0000099)2.86347454
56Acanthocytosis (HP:0001927)2.86023848
57Vaginal fistula (HP:0004320)2.80295154
58Conjugated hyperbilirubinemia (HP:0002908)2.80052438
59Systemic lupus erythematosus (HP:0002725)2.75497509
60Irregular epiphyses (HP:0010582)2.72481811
61Metabolic acidosis (HP:0001942)2.72287938
62Abnormality of serum amino acid levels (HP:0003112)2.71344639
63Thrombophlebitis (HP:0004418)2.68302837
64Hepatoblastoma (HP:0002884)2.66014211
65Cholecystitis (HP:0001082)2.64860778
66Abnormal gallbladder physiology (HP:0012438)2.64860778
67Ketoacidosis (HP:0001993)2.64687936
68Abnormality of purine metabolism (HP:0004352)2.61379567
69Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.61281251
70Absent epiphyses (HP:0010577)2.61281251
71Myocardial infarction (HP:0001658)2.55115324
72Increased serum pyruvate (HP:0003542)2.54393041
73Menorrhagia (HP:0000132)2.53823655
74Delayed CNS myelination (HP:0002188)2.53735314
75Lethargy (HP:0001254)2.53677753
76Skin nodule (HP:0200036)2.53642546
77Abnormality of the nasal septum (HP:0000419)2.53587033
78Abnormal gallbladder morphology (HP:0012437)2.52744693
79Cholelithiasis (HP:0001081)2.51176151
80Abnormality of glycolysis (HP:0004366)2.50149969
81Esophageal varix (HP:0002040)2.49352261
82Steatorrhea (HP:0002570)2.49308779
83Cerebral edema (HP:0002181)2.48964715
84Enlarged kidneys (HP:0000105)2.44817695
85Flared iliac wings (HP:0002869)2.43278607
86Poikilocytosis (HP:0004447)2.41761608
87Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.40618535
88Diastasis recti (HP:0001540)2.38235052
89Hypophosphatemic rickets (HP:0004912)2.37384393
90Abnormality of the wing of the ilium (HP:0011867)2.37182389
91Abnormality of the lumbar spine (HP:0100712)2.36461141
92Recurrent gram-negative bacterial infections (HP:0005420)2.36231600
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.35285161
94Dicarboxylic aciduria (HP:0003215)2.35285161
95Vascular calcification (HP:0004934)2.34976809
96Irritability (HP:0000737)2.34630130
97Spastic diplegia (HP:0001264)2.30156865
98Neonatal onset (HP:0003623)2.29994092
99Abnormal foot bone ossification (HP:0010675)2.29252724
100Pancreatitis (HP:0001733)2.27161230
101Hypoglycemic seizures (HP:0002173)2.26793178
102Protrusio acetabuli (HP:0003179)2.22527483
103Limited elbow extension (HP:0001377)2.21200309
104Cupped ribs (HP:0000887)2.19770633
105Alacrima (HP:0000522)2.19517947
106Mitral stenosis (HP:0001718)2.19242173
107Abnormality of iron homeostasis (HP:0011031)2.16374981
108Arthropathy (HP:0003040)2.13579325
109Abnormality of the acetabulum (HP:0003170)2.10265785
110Cardiovascular calcification (HP:0011915)2.09504094
111Facial shape deformation (HP:0011334)2.08583799
112Potter facies (HP:0002009)2.08583799
113Vomiting (HP:0002013)2.07206739
114Abnormality of transition element cation homeostasis (HP:0011030)2.05129609
115Abnormality of the gallbladder (HP:0005264)2.02017781
116Nephritis (HP:0000123)1.97979859
117Hemorrhage of the eye (HP:0011885)1.97621975
118Neonatal death (HP:0003811)1.96090067
119Increased purine levels (HP:0004368)1.94763876
120Hyperuricemia (HP:0002149)1.94763876
121Sensorimotor neuropathy (HP:0007141)1.94712072
122Malnutrition (HP:0004395)1.93191043
123Generalized aminoaciduria (HP:0002909)1.92692157
124Scanning speech (HP:0002168)1.92566560
125Epistaxis (HP:0000421)1.91861266
126Abnormality of pain sensation (HP:0010832)1.90747918
127Impaired pain sensation (HP:0007328)1.90747918
128Wide nose (HP:0000445)1.89967673
129Joint swelling (HP:0001386)1.89559290
130Pulmonary embolism (HP:0002204)1.89525812
131Hydroxyprolinuria (HP:0003080)1.88700284
132Abnormality of proline metabolism (HP:0010907)1.88700284
133Abnormality of endocrine pancreas physiology (HP:0012093)1.88419256
134Abnormality of the pancreatic islet cells (HP:0006476)1.88419256
135Late onset (HP:0003584)1.87644444
136Hypertriglyceridemia (HP:0002155)1.87265607
137Renal duplication (HP:0000075)1.86378514
138Alkalosis (HP:0001948)1.84628570
139Brushfield spots (HP:0001088)1.84512925
140Hyperinsulinemic hypoglycemia (HP:0000825)1.82249428
141Elevated hepatic transaminases (HP:0002910)1.81425134
142Reticulocytosis (HP:0001923)1.79366035
143Rickets (HP:0002748)1.79189907
144Abnormality of the Achilles tendon (HP:0005109)1.79095165
145Increased serum ferritin (HP:0003281)1.78572063
146Confusion (HP:0001289)1.77122450
147Metaphyseal irregularity (HP:0003025)1.77106113
148Pigmentary retinal degeneration (HP:0001146)1.76993072
149Coxa vara (HP:0002812)1.76404012
150Abnormal cartilage morphology (HP:0002763)1.75621257
151Abnormality of the alveolar ridges (HP:0006477)1.74205601
152Supernumerary spleens (HP:0009799)1.70989139
153Submucous cleft hard palate (HP:0000176)1.67234746
154Abnormal delivery (HP:0001787)1.66407415
155Osteomalacia (HP:0002749)1.65496596
156Bifid scrotum (HP:0000048)1.65421789
157Widely patent fontanelles and sutures (HP:0004492)1.64410203

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.60423511
2ERN15.40175192
3FGFR44.75045765
4WNK44.30127736
5SIK13.07711105
6ERBB43.07509909
7TYRO33.05455414
8CDK122.81389445
9INSRR2.53334698
10FGFR12.37003308
11PIK3CA2.35149315
12TRIB32.32905396
13MAP2K42.28632115
14MAPK112.22842999
15TAOK32.21908742
16MST1R2.18203159
17PKN22.13600459
18WNK12.09562642
19EEF2K1.89070935
20SIK21.88184064
21DAPK21.77393266
22TYK21.73516516
23PTK61.71923561
24AKT31.71269435
25FLT31.67406273
26EPHB11.61012941
27KDR1.51366201
28GRK61.50667926
29DDR21.46907743
30ABL21.42476773
31NEK91.41465501
32IRAK31.32507643
33JAK21.31755706
34EPHA31.31348428
35ERBB21.30954775
36LATS11.25998963
37MAP2K31.12891008
38MAP3K111.12714543
39TBK11.10449613
40MAP3K31.07845541
41MAPK41.05975159
42LATS21.02949461
43CDK71.02446595
44MET1.00404579
45PRKAA21.00272550
46PIK3CG0.99906149
47STK390.99639059
48FGR0.98479321
49MAPKAPK30.96313018
50PINK10.96097456
51JAK10.95493429
52NEK20.95431130
53RIPK10.92225131
54MAPK120.91205876
55CAMK2G0.90663273
56TGFBR20.89542495
57PRKACG0.89353729
58MAP3K100.87766617
59BRSK10.87739577
60TIE10.86743069
61MAP3K70.82211598
62PTK20.80220732
63GSK3A0.79358936
64FRK0.78910784
65SMG10.78237316
66CDC42BPA0.78041840
67NEK10.77436174
68PRKCZ0.75166265
69FGFR20.74280843
70RPS6KB10.72508543
71MAP2K10.71733237
72SGK10.71400230
73CSK0.69400788
74CDK80.66808106
75DYRK1B0.64273762
76CDK60.60749742
77MAP3K60.59893928
78NTRK30.59848590
79NTRK20.58887597
80PDPK10.56202079
81MAP2K20.55123914
82MAP2K60.54909707
83PKN10.54742534
84MAPK150.52169706
85PRKAA10.51296893
86CSF1R0.49327220
87* CSNK1E0.48967267
88SGK30.47684417
89MATK0.47064394
90IKBKE0.46792909
91PRKCG0.45575811
92FGFR30.45236988
93MAP3K140.45160089
94MARK20.44696908
95MAPK70.44508077
96BRD40.43904698
97EGFR0.43318346
98EPHA20.43280749
99MAP4K10.43274224
100MAP3K10.43028872
101BMX0.42891139
102STK38L0.42792664
103RET0.42108654
104PRKCQ0.40929071
105BCR0.39553120
106MTOR0.39328189
107BRSK20.39028047
108CDK40.38662281
109EIF2AK10.35097915
110CAMK40.35034657
111PBK0.34962629
112SRC0.34718237
113PDK10.34414186
114MAP3K90.33869804
115SGK4940.32522393
116SGK2230.32522393
117CAMK1D0.32419137
118PAK30.32224262
119PDGFRB0.31496798
120RPS6KB20.31128527
121ICK0.31001333
122IGF1R0.30686124
123DAPK30.29766197
124MELK0.29229769
125MAP3K50.29102139
126PRKACB0.28896219
127EPHA40.28650439
128YES10.27920983
129CSNK1D0.27897432
130MAPKAPK50.27819873
131PRKCA0.27672981
132NTRK10.26607383
133GRK10.26491929
134SGK20.26271917
135CDK10.25953809
136CDK90.25431695
137KSR20.24838035
138PDGFRA0.24558014
139MAPKAPK20.24458500
140RPS6KA30.24244451
141EPHB20.24196572
142LMTK20.24163013
143ALK0.23780675
144MAP3K20.23609426
145CDK150.23349531
146MAPK100.21204186
147NME20.19816707
148MAPK30.19509455
149CSNK1G10.18008269

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.23516394
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.13317126
3Nitrogen metabolism_Homo sapiens_hsa009104.02944695
4Arginine biosynthesis_Homo sapiens_hsa002203.47447227
5Complement and coagulation cascades_Homo sapiens_hsa046103.32866047
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.84027037
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.73040693
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.72465674
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52400848
10Fatty acid degradation_Homo sapiens_hsa000712.46165097
11Tryptophan metabolism_Homo sapiens_hsa003802.44428715
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23621749
13Staphylococcus aureus infection_Homo sapiens_hsa051502.06556253
14Butanoate metabolism_Homo sapiens_hsa006502.03508699
15Peroxisome_Homo sapiens_hsa041461.98940757
16PPAR signaling pathway_Homo sapiens_hsa033201.98091459
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.91988110
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.87988982
19Fatty acid metabolism_Homo sapiens_hsa012121.85014403
20Other glycan degradation_Homo sapiens_hsa005111.79972251
21Propanoate metabolism_Homo sapiens_hsa006401.77135750
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75244535
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73228259
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72325155
25Phenylalanine metabolism_Homo sapiens_hsa003601.71022463
26Histidine metabolism_Homo sapiens_hsa003401.69129113
27Chemical carcinogenesis_Homo sapiens_hsa052041.68331024
28Selenocompound metabolism_Homo sapiens_hsa004501.67578324
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.61090565
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59897954
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54538877
32beta-Alanine metabolism_Homo sapiens_hsa004101.53453334
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.48142247
34Tyrosine metabolism_Homo sapiens_hsa003501.43258919
35Biosynthesis of amino acids_Homo sapiens_hsa012301.40237715
36Bile secretion_Homo sapiens_hsa049761.38991935
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.36272523
38Fat digestion and absorption_Homo sapiens_hsa049751.35053809
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34678619
40Fatty acid elongation_Homo sapiens_hsa000621.34303163
41Pyruvate metabolism_Homo sapiens_hsa006201.32176925
42Steroid biosynthesis_Homo sapiens_hsa001001.30580474
43Caffeine metabolism_Homo sapiens_hsa002321.28729151
44Retinol metabolism_Homo sapiens_hsa008301.26075887
45Sulfur metabolism_Homo sapiens_hsa009201.23658062
46Folate biosynthesis_Homo sapiens_hsa007901.23073186
47Carbon metabolism_Homo sapiens_hsa012001.21354895
48Starch and sucrose metabolism_Homo sapiens_hsa005001.18743020
49N-Glycan biosynthesis_Homo sapiens_hsa005101.10299317
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07611427
51Vitamin digestion and absorption_Homo sapiens_hsa049771.06821472
52ABC transporters_Homo sapiens_hsa020101.06592875
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04660286
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.01382013
55Arginine and proline metabolism_Homo sapiens_hsa003300.99241104
56Sulfur relay system_Homo sapiens_hsa041220.99092666
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97870340
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.95643349
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93688834
60Vitamin B6 metabolism_Homo sapiens_hsa007500.93141711
61Pentose phosphate pathway_Homo sapiens_hsa000300.81444247
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76940713
63One carbon pool by folate_Homo sapiens_hsa006700.72875398
64Lysine degradation_Homo sapiens_hsa003100.71505472
65Glutathione metabolism_Homo sapiens_hsa004800.63409446
66Glycerolipid metabolism_Homo sapiens_hsa005610.59485215
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51916442
68ECM-receptor interaction_Homo sapiens_hsa045120.46308163
69Metabolic pathways_Homo sapiens_hsa011000.46009619
70Fatty acid biosynthesis_Homo sapiens_hsa000610.44470107
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41810038
72Mineral absorption_Homo sapiens_hsa049780.40710971
73Fructose and mannose metabolism_Homo sapiens_hsa000510.40486213
74Galactose metabolism_Homo sapiens_hsa000520.36905573
75Non-small cell lung cancer_Homo sapiens_hsa052230.34963585
76HIF-1 signaling pathway_Homo sapiens_hsa040660.34470911
77Prion diseases_Homo sapiens_hsa050200.32154796
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.30953834
79Insulin resistance_Homo sapiens_hsa049310.26657256
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25844502
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24912067
82Sphingolipid metabolism_Homo sapiens_hsa006000.21982414
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.17822107
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17534246
85Glucagon signaling pathway_Homo sapiens_hsa049220.17508684
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16896402
87Linoleic acid metabolism_Homo sapiens_hsa005910.13490972
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.12877964
89Proteoglycans in cancer_Homo sapiens_hsa052050.09676086
90AMPK signaling pathway_Homo sapiens_hsa041520.09147525
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08171485
92mTOR signaling pathway_Homo sapiens_hsa041500.07878094
93Adherens junction_Homo sapiens_hsa045200.07271408
94Circadian rhythm_Homo sapiens_hsa047100.04333758
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.03220163
96Wnt signaling pathway_Homo sapiens_hsa043100.01360913
97Lysosome_Homo sapiens_hsa04142-0.2577349
98Regulation of autophagy_Homo sapiens_hsa04140-0.2488277
99Ether lipid metabolism_Homo sapiens_hsa00565-0.2471208
100Pertussis_Homo sapiens_hsa05133-0.2053849
101Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1901241
102Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1813755
103Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1791436
104Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1594964
105Bladder cancer_Homo sapiens_hsa05219-0.1561839
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1314596
107Hepatitis C_Homo sapiens_hsa05160-0.1274098
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1070151
109Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1056918
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0995700
111Renin-angiotensin system_Homo sapiens_hsa04614-0.0855832
112Insulin signaling pathway_Homo sapiens_hsa04910-0.0853319
113African trypanosomiasis_Homo sapiens_hsa05143-0.0444596
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0435639
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0387280
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0111468
117Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0006245

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