IGFBP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.82444847
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.82444847
3L-phenylalanine metabolic process (GO:0006558)6.65552463
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.65552463
5aromatic amino acid family catabolic process (GO:0009074)6.14043627
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.79270492
7protein heterotrimerization (GO:0070208)5.76751436
8glyoxylate metabolic process (GO:0046487)5.65173384
9protein carboxylation (GO:0018214)5.57639469
10peptidyl-glutamic acid carboxylation (GO:0017187)5.57639469
11indole-containing compound catabolic process (GO:0042436)5.52425326
12indolalkylamine catabolic process (GO:0046218)5.52425326
13tryptophan catabolic process (GO:0006569)5.52425326
14negative regulation of fibrinolysis (GO:0051918)5.49407274
15kynurenine metabolic process (GO:0070189)5.41527744
16skin morphogenesis (GO:0043589)5.38186801
17bile acid biosynthetic process (GO:0006699)5.29652730
18alpha-linolenic acid metabolic process (GO:0036109)5.28476418
19regulation of fibrinolysis (GO:0051917)5.25702646
20tryptophan metabolic process (GO:0006568)5.19878950
21urea cycle (GO:0000050)5.05536273
22urea metabolic process (GO:0019627)5.05536273
23sulfur amino acid catabolic process (GO:0000098)5.02705684
24high-density lipoprotein particle remodeling (GO:0034375)4.95845221
25regulation of protein activation cascade (GO:2000257)4.95568389
26complement activation, alternative pathway (GO:0006957)4.90200958
27cysteine metabolic process (GO:0006534)4.88165659
28serine family amino acid catabolic process (GO:0009071)4.67087952
29regulation of complement activation (GO:0030449)4.66746318
30collagen fibril organization (GO:0030199)4.66267334
31nitrogen cycle metabolic process (GO:0071941)4.66237077
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.65551569
33homocysteine metabolic process (GO:0050667)4.61108541
34lysine catabolic process (GO:0006554)4.57618212
35lysine metabolic process (GO:0006553)4.57618212
36extracellular fibril organization (GO:0043206)4.50036532
37amino-acid betaine metabolic process (GO:0006577)4.46624616
38bile acid metabolic process (GO:0008206)4.45090805
39aromatic amino acid family metabolic process (GO:0009072)4.41392107
40regulation of triglyceride catabolic process (GO:0010896)4.39276426
41extracellular matrix assembly (GO:0085029)4.38271740
42reverse cholesterol transport (GO:0043691)4.36459812
43protein-lipid complex remodeling (GO:0034368)4.31455548
44macromolecular complex remodeling (GO:0034367)4.31455548
45plasma lipoprotein particle remodeling (GO:0034369)4.31455548
46regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.29871936
47tyrosine metabolic process (GO:0006570)4.27920750
48endodermal cell differentiation (GO:0035987)4.27551630
49regulation of cholesterol esterification (GO:0010872)4.25906273
50acylglycerol homeostasis (GO:0055090)4.22766490
51triglyceride homeostasis (GO:0070328)4.22766490
52plasma lipoprotein particle clearance (GO:0034381)4.22005508
53alpha-amino acid catabolic process (GO:1901606)4.20622316
54cell migration involved in heart development (GO:0060973)4.20323566
55adhesion of symbiont to host cell (GO:0044650)4.19840599
56virion attachment to host cell (GO:0019062)4.19840599
57negative regulation of cholesterol transport (GO:0032375)4.12628482
58negative regulation of sterol transport (GO:0032372)4.12628482
59glycine metabolic process (GO:0006544)4.10003871
60basement membrane organization (GO:0071711)4.09346792
61vascular endothelial growth factor signaling pathway (GO:0038084)4.07779517
62phospholipid efflux (GO:0033700)4.06467725
63fibrinolysis (GO:0042730)4.05501118
64fibril organization (GO:0097435)4.00916286
65sequestering of extracellular ligand from receptor (GO:0035581)3.99380966
66regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.98551962
67cellular glucuronidation (GO:0052695)3.96045503
68cellular modified amino acid catabolic process (GO:0042219)3.94434209
69cellular ketone body metabolic process (GO:0046950)3.91435414
70drug catabolic process (GO:0042737)3.91197544
71cellular amino acid catabolic process (GO:0009063)3.89722341
72serine family amino acid metabolic process (GO:0009069)3.88866986
73serine family amino acid biosynthetic process (GO:0009070)3.81081260
74kidney mesenchyme development (GO:0072074)3.79573096
75adhesion of symbiont to host (GO:0044406)3.79535278
76negative regulation of smooth muscle cell migration (GO:0014912)3.78303012
77indolalkylamine metabolic process (GO:0006586)3.76966358
78benzene-containing compound metabolic process (GO:0042537)3.76211364
79imidazole-containing compound metabolic process (GO:0052803)3.75703320
80bile acid and bile salt transport (GO:0015721)3.75521568
81coenzyme catabolic process (GO:0009109)3.75409125
82ethanol oxidation (GO:0006069)3.74352129
83aldehyde catabolic process (GO:0046185)3.73572117
84amine catabolic process (GO:0009310)3.72983336
85cellular biogenic amine catabolic process (GO:0042402)3.72983336
86arginine metabolic process (GO:0006525)3.71753880
87positive regulation of endothelial cell apoptotic process (GO:2000353)3.71645208
88positive regulation of fatty acid beta-oxidation (GO:0032000)3.70550219
89Golgi transport vesicle coating (GO:0048200)3.69186789
90COPI coating of Golgi vesicle (GO:0048205)3.69186789
91collagen metabolic process (GO:0032963)3.69115083
92opsonization (GO:0008228)3.67701651
93blood vessel maturation (GO:0001955)3.67416962
94glutamate metabolic process (GO:0006536)3.67126056
95epoxygenase P450 pathway (GO:0019373)3.66989490
96chondrocyte proliferation (GO:0035988)3.66920909
97metanephric mesenchyme development (GO:0072075)3.60155735
98cholesterol efflux (GO:0033344)3.60041030
99blood coagulation, intrinsic pathway (GO:0007597)3.59585116
100positive regulation of lipid catabolic process (GO:0050996)3.59153261
101glucuronate metabolic process (GO:0019585)3.58986080
102uronic acid metabolic process (GO:0006063)3.58986080
103negative regulation of lipase activity (GO:0060192)3.58800518
104protein retention in ER lumen (GO:0006621)3.58431564
105bone trabecula formation (GO:0060346)3.57927225
106regulation of plasminogen activation (GO:0010755)3.56426046
107plasma lipoprotein particle assembly (GO:0034377)3.55179895
108barbed-end actin filament capping (GO:0051016)3.51740412
109low-density lipoprotein particle remodeling (GO:0034374)3.50387937
110urate metabolic process (GO:0046415)3.50195039
111maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.48830734
112cell adhesion mediated by integrin (GO:0033627)3.48562602
113drug transmembrane transport (GO:0006855)3.47715700
114exogenous drug catabolic process (GO:0042738)3.47711998
1152-oxoglutarate metabolic process (GO:0006103)3.47649196
116positive regulation of triglyceride lipase activity (GO:0061365)3.47197396
117positive regulation of lipoprotein lipase activity (GO:0051006)3.47197396
118cholesterol homeostasis (GO:0042632)3.45949680
119multicellular organismal macromolecule metabolic process (GO:0044259)3.45655773
120organic acid catabolic process (GO:0016054)3.45605470
121carboxylic acid catabolic process (GO:0046395)3.45605470
122collagen catabolic process (GO:0030574)3.45423307
123regulation of cholesterol homeostasis (GO:2000188)3.45153128
124dicarboxylic acid biosynthetic process (GO:0043650)3.42093643
125sterol homeostasis (GO:0055092)3.41759344
126valine metabolic process (GO:0006573)3.40560459
127protein activation cascade (GO:0072376)3.39867795
128lipoprotein metabolic process (GO:0042157)3.37060404
129short-chain fatty acid metabolic process (GO:0046459)3.37048785
130ketone body metabolic process (GO:1902224)3.36774814
131phospholipid homeostasis (GO:0055091)3.34701464
132complement activation (GO:0006956)3.34359364
133endothelial cell morphogenesis (GO:0001886)3.31659248
134apoptotic cell clearance (GO:0043277)3.30603777
135protein localization to endosome (GO:0036010)3.30516907
136planar cell polarity pathway involved in neural tube closure (GO:0090179)3.27397205
137extracellular matrix disassembly (GO:0022617)3.26935678
138retina vasculature morphogenesis in camera-type eye (GO:0061299)3.26812091
139multicellular organismal metabolic process (GO:0044236)3.25808617
140regulation of extracellular matrix disassembly (GO:0010715)3.23807915
141cellular response to vitamin (GO:0071295)3.22130867
142positive regulation of blood vessel endothelial cell migration (GO:0043536)3.20057451
143substrate-dependent cell migration (GO:0006929)3.18798551
144* type B pancreatic cell proliferation (GO:0044342)3.18306935
145cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.18291491
146multicellular organismal catabolic process (GO:0044243)3.17611248
147endocardial cushion development (GO:0003197)3.16995742
148tooth mineralization (GO:0034505)3.16462853
149stress fiber assembly (GO:0043149)3.16307624
150hyaluronan catabolic process (GO:0030214)3.16066254
151vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.15457272
152peptidyl-proline hydroxylation (GO:0019511)3.10109412
153negative regulation of chondrocyte differentiation (GO:0032331)3.07895001
154cell-substrate junction assembly (GO:0007044)3.07308366
155negative regulation of fatty acid transport (GO:2000192)3.06549302
156regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.06051673
157glomerular basement membrane development (GO:0032836)3.00875290
158cell migration involved in sprouting angiogenesis (GO:0002042)3.00191137
159extracellular matrix organization (GO:0030198)2.93712706
160mesenchymal-epithelial cell signaling (GO:0060638)2.93501340
161wound healing, spreading of epidermal cells (GO:0035313)2.93221176
162extracellular structure organization (GO:0043062)2.92632254
163protein maturation by protein folding (GO:0022417)2.89183676
164adherens junction assembly (GO:0034333)2.87480222
165positive regulation of extracellular matrix organization (GO:1903055)2.84258196
166protein hydroxylation (GO:0018126)2.82153738
167muscle cell migration (GO:0014812)2.81470320
168neuron projection extension involved in neuron projection guidance (GO:1902284)2.79539482
169axon extension involved in axon guidance (GO:0048846)2.79539482
170venous blood vessel morphogenesis (GO:0048845)2.79103487
171embryo implantation (GO:0007566)2.78916525
172peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.78496864
173regulation of smooth muscle cell migration (GO:0014910)2.75208406
174positive regulation of osteoblast proliferation (GO:0033690)2.73970468
175keratan sulfate catabolic process (GO:0042340)2.73933716
176regulation of collagen metabolic process (GO:0010712)2.72338409
177heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.72201320
178cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.71806127
179regulation of endothelial cell apoptotic process (GO:2000351)2.71455527
180hemidesmosome assembly (GO:0031581)2.71413566
181cell-substrate adherens junction assembly (GO:0007045)2.68867934
182focal adhesion assembly (GO:0048041)2.68867934
183endothelial cell chemotaxis (GO:0035767)2.68661275
184cell proliferation involved in metanephros development (GO:0072203)2.66610432
185trabecula formation (GO:0060343)2.66334706
186positive regulation of receptor recycling (GO:0001921)2.62515783
187regulation of early endosome to late endosome transport (GO:2000641)2.61249269
188pinocytosis (GO:0006907)2.60472827
189positive regulation of collagen biosynthetic process (GO:0032967)2.58548812
190lung vasculature development (GO:0060426)2.58295048
191substrate adhesion-dependent cell spreading (GO:0034446)2.58214409
192epithelial cell-cell adhesion (GO:0090136)2.57702023
193regulation of integrin-mediated signaling pathway (GO:2001044)2.56444460
194dermatan sulfate metabolic process (GO:0030205)2.55679264
195extracellular negative regulation of signal transduction (GO:1900116)2.54202939
196extracellular regulation of signal transduction (GO:1900115)2.54202939
197blood vessel endothelial cell migration (GO:0043534)2.52994219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.84508986
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.69389508
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.00482194
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.98178293
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.91621735
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.52814657
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.39562666
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.60501348
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.32505714
10* CLOCK_20551151_ChIP-Seq_293T_Human2.63993201
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.56283864
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.40959872
13WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.09457199
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.02848085
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02218504
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1486213
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99242179
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.91550825
19BRD4_25478319_ChIP-Seq_HGPS_Human1.88769586
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.88372984
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80824292
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.74625611
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68370090
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.62726016
25* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.60795074
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59507411
27TP53_22127205_ChIP-Seq_IMR90_Human1.58963875
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57103364
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.56465626
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55312909
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53595389
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50917522
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50200395
34UBF1/2_26484160_Chip-Seq_HMECs_Human1.47377099
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42464057
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42464057
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41490133
38* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39243905
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.38578194
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.38523974
41ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.37388131
42JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37161418
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35823934
44KDM2B_26808549_Chip-Seq_K562_Human1.35660058
45* FOXA2_19822575_ChIP-Seq_HepG2_Human1.35400991
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35324068
47GATA1_22025678_ChIP-Seq_K562_Human1.30828886
48* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30819499
49SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23581684
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23443825
51HNF4A_19822575_ChIP-Seq_HepG2_Human1.22812509
52* SA1_22415368_ChIP-Seq_MEFs_Mouse1.22404978
53JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21526896
54TP53_23651856_ChIP-Seq_MEFs_Mouse1.20441557
55TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20169465
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19769417
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.18611853
58* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17037532
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15891130
60LXR_22292898_ChIP-Seq_THP-1_Human1.15729368
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15618540
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.15473655
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14692679
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13074648
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12959738
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.12684715
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12352350
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09877156
69EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08083191
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07813485
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.05114203
72DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04863147
73* KDM2B_26808549_Chip-Seq_DND41_Human1.04519822
74* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04213831
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03950512
76NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03276834
77RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02918006
78TET1_21490601_ChIP-Seq_MESCs_Mouse1.02552044
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01622184
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98911483
81KDM2B_26808549_Chip-Seq_JURKAT_Human0.98301674
82* ELK3_25401928_ChIP-Seq_HUVEC_Human0.98287134
83RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98286214
84EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98286214
85ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96534100
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94957554
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94926973
88FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94798033
89* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94397672
90* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93025447
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90898426
92IRF8_22096565_ChIP-ChIP_GC-B_Human0.89993286
93* ESR1_21235772_ChIP-Seq_MCF-7_Human0.89713159
94HTT_18923047_ChIP-ChIP_STHdh_Human0.88349982
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87594121
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86993103
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85477353
98GATA4_25053715_ChIP-Seq_YYC3_Human0.84864626
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84802317
100* ESR2_21235772_ChIP-Seq_MCF-7_Human0.82917857
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.79870740
102SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77742584
103* RACK7_27058665_Chip-Seq_MCF-7_Human0.77481395
104NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74346836
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74346836
106* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.72076788
107ZNF263_19887448_ChIP-Seq_K562_Human0.71547001
108CDX2_20551321_ChIP-Seq_CACO-2_Human0.70831684
109PPAR_26484153_Chip-Seq_NCI-H1993_Human0.70362680
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.69934114
111* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67650612
112AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67058418
113* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.66960908
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66485851
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64145791
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.62584805
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62223521
118RARA_24833708_ChIP-Seq_LIVER_Mouse0.61156597
119* TBX20_22328084_ChIP-Seq_HEART_Mouse0.61031802
120* TBX20_22080862_ChIP-Seq_HEART_Mouse0.61031802
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60395787
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.59278966
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.59087449
124* RARB_24833708_ChIP-Seq_LIVER_Mouse0.56882041
125STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.56816733
126BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.56584402
127CJUN_26792858_Chip-Seq_BT549_Human0.56579783
128* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.56445573
129SOX2_20726797_ChIP-Seq_SW620_Human0.56430755
130P63_26484246_Chip-Seq_KERATINOCYTES_Human0.56381541
131* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.56287244
132Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.56267272
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.55136612
134CEBPB_22108803_ChIP-Seq_LS180_Human0.54620902
135NFIB_24661679_ChIP-Seq_LUNG_Mouse0.54328526
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.53820454
137* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52081267
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.50989080
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.50718463
140* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.50467261
141* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50361225
142CSB_26484114_Chip-Seq_FIBROBLAST_Human0.50176400
143* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.49851115
144ATF3_27146783_Chip-Seq_COLON_Human0.49709166
145* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.47666413
146AR_21909140_ChIP-Seq_LNCAP_Human0.47120276
147HIF1A_21447827_ChIP-Seq_MCF-7_Human0.45164087
148GATA6_25053715_ChIP-Seq_YYC3_Human0.44544507
149GATA1_19941826_ChIP-Seq_K562_Human0.44249686
150* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.44085595
151AR_20517297_ChIP-Seq_VCAP_Human0.43662919
152WT1_19549856_ChIP-ChIP_CCG9911_Human0.43650583
153* CTCF_21964334_Chip-Seq_Bcells_Human0.42707886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.99265106
2MP0005360_urolithiasis6.79473900
3MP0005085_abnormal_gallbladder_physiolo5.22414457
4MP0005365_abnormal_bile_salt5.18126387
5MP0008875_abnormal_xenobiotic_pharmacok4.22664741
6MP0003252_abnormal_bile_duct3.52198236
7MP0005257_abnormal_intraocular_pressure3.44003513
8MP0003806_abnormal_nucleotide_metabolis3.26390764
9MP0008438_abnormal_cutaneous_collagen3.19292321
10MP0010329_abnormal_lipoprotein_level3.14104142
11MP0003705_abnormal_hypodermis_morpholog3.09924350
12MP0009840_abnormal_foam_cell2.83206346
13MP0005083_abnormal_biliary_tract2.56562030
14MP0010368_abnormal_lymphatic_system2.48816473
15MP0005332_abnormal_amino_acid2.46901504
16MP0003191_abnormal_cellular_cholesterol2.27295531
17MP0003195_calcinosis2.23841299
18MP0000751_myopathy2.18343295
19MP0001666_abnormal_nutrient_absorption2.05287299
20MP0004019_abnormal_vitamin_homeostasis2.02736738
21MP0005275_abnormal_skin_tensile1.93338367
22MP0005623_abnormal_meninges_morphology1.91885728
23MP0000609_abnormal_liver_physiology1.91214385
24MP0003091_abnormal_cell_migration1.90304006
25MP0002138_abnormal_hepatobiliary_system1.87067690
26MP0002118_abnormal_lipid_homeostasis1.72009099
27MP0003279_aneurysm1.70181012
28MP0000013_abnormal_adipose_tissue1.68566965
29MP0005319_abnormal_enzyme/_coenzyme1.67347047
30MP0005503_abnormal_tendon_morphology1.63416640
31MP0002877_abnormal_melanocyte_morpholog1.59152144
32MP0010030_abnormal_orbit_morphology1.51830814
33MP0009384_cardiac_valve_regurgitation1.51583946
34MP0004858_abnormal_nervous_system1.47534587
35MP0002108_abnormal_muscle_morphology1.47311170
36MP0003724_increased_susceptibility_to1.41102281
37MP0003950_abnormal_plasma_membrane1.38587832
38MP0003868_abnormal_feces_composition1.37599466
39MP0001849_ear_inflammation1.29034883
40MP0009643_abnormal_urine_homeostasis1.28946293
41MP0005584_abnormal_enzyme/coenzyme_acti1.27765341
42MP0005058_abnormal_lysosome_morphology1.22740599
43MP0005670_abnormal_white_adipose1.22536661
44MP0010352_gastrointestinal_tract_polyps1.22445061
45MP0003186_abnormal_redox_activity1.22122801
46MP0001958_emphysema1.22095650
47MP0009697_abnormal_copulation1.20533059
48MP0004272_abnormal_basement_membrane1.20157960
49MP0009053_abnormal_anal_canal1.18134378
50MP0000598_abnormal_liver_morphology1.18050751
51MP0000534_abnormal_ureter_morphology1.16686320
52MP0001764_abnormal_homeostasis1.16115415
53MP0006054_spinal_hemorrhage1.15286468
54MP0001348_abnormal_lacrimal_gland1.12488019
55MP0009780_abnormal_chondrocyte_physiolo1.11206231
56MP0001299_abnormal_eye_distance/1.07946827
57MP0000003_abnormal_adipose_tissue1.07797636
58MP0003941_abnormal_skin_development1.07745815
59MP0009764_decreased_sensitivity_to1.05366549
60MP0004510_myositis1.03730779
61MP0009250_abnormal_appendicular_skeleto0.99685844
62MP0003942_abnormal_urinary_system0.98036856
63MP0002060_abnormal_skin_morphology0.96469714
64MP0005165_increased_susceptibility_to0.96170868
65MP0009763_increased_sensitivity_to0.95917996
66MP0005451_abnormal_body_composition0.94016678
67MP0000733_abnormal_muscle_development0.93714546
68MP0003011_delayed_dark_adaptation0.93498166
69MP0002998_abnormal_bone_remodeling0.92858268
70MP0001879_abnormal_lymphatic_vessel0.91608286
71MP0005647_abnormal_sex_gland0.91465352
72MP0005084_abnormal_gallbladder_morpholo0.91412929
73MP0003385_abnormal_body_wall0.90980294
74MP0001614_abnormal_blood_vessel0.90617774
75MP0006138_congestive_heart_failure0.89211484
76MP0000428_abnormal_craniofacial_morphol0.87206666
77MP0005220_abnormal_exocrine_pancreas0.87050861
78MP0001243_abnormal_dermal_layer0.86346355
79MP0005076_abnormal_cell_differentiation0.86339940
80MP0002295_abnormal_pulmonary_circulatio0.85146275
81MP0000759_abnormal_skeletal_muscle0.84758039
82MP0005023_abnormal_wound_healing0.83544259
83MP0008469_abnormal_protein_level0.82234347
84MP0005197_abnormal_uvea_morphology0.81364030
85MP0003448_altered_tumor_morphology0.80782068
86MP0005636_abnormal_mineral_homeostasis0.80438666
87MP0000750_abnormal_muscle_regeneration0.80340968
88MP0000343_altered_response_to0.79992691
89MP0003300_gastrointestinal_ulcer0.78638117
90MP0002932_abnormal_joint_morphology0.76946187
91MP0000858_altered_metastatic_potential0.76765085
92MP0002113_abnormal_skeleton_development0.75959235
93MP0000762_abnormal_tongue_morphology0.75640132
94MP0005666_abnormal_adipose_tissue0.75160316
95MP0000462_abnormal_digestive_system0.74877098
96MP0003115_abnormal_respiratory_system0.74100206
97MP0009642_abnormal_blood_homeostasis0.73824080
98MP0003828_pulmonary_edema0.73006058
99MP0004130_abnormal_muscle_cell0.72371814
100MP0002254_reproductive_system_inflammat0.71645633
101MP0000049_abnormal_middle_ear0.71447106
102MP0005409_darkened_coat_color0.71431644
103MP0000604_amyloidosis0.71116741
104MP0002925_abnormal_cardiovascular_devel0.70756009
105MP0001661_extended_life_span0.70389690
106MP0003656_abnormal_erythrocyte_physiolo0.70096683
107MP0001756_abnormal_urination0.70052123
108MP0003795_abnormal_bone_structure0.69110362
109MP0000749_muscle_degeneration0.68976916
110MP0002971_abnormal_brown_adipose0.68267020
111MP0001175_abnormal_lung_morphology0.68235840
112MP0000467_abnormal_esophagus_morphology0.68018040
113MP0002133_abnormal_respiratory_system0.65309132
114MP0005388_respiratory_system_phenotype0.65309132
115MP0005595_abnormal_vascular_smooth0.64284787
116MP0000249_abnormal_blood_vessel0.64176837
117MP0005375_adipose_tissue_phenotype0.63509494
118MP0002089_abnormal_postnatal_growth/wei0.61949684
119MP0002136_abnormal_kidney_physiology0.61750076
120MP0003436_decreased_susceptibility_to0.60398806
121MP0005376_homeostasis/metabolism_phenot0.60328652
122MP0001533_abnormal_skeleton_physiology0.59742620
123MP0000767_abnormal_smooth_muscle0.58982943
124MP0005408_hypopigmentation0.58621221
125MP0004233_abnormal_muscle_weight0.57604998
126MP0001542_abnormal_bone_strength0.57286192
127MP0000432_abnormal_head_morphology0.56606199
128MP0005334_abnormal_fat_pad0.56120433
129MP0002796_impaired_skin_barrier0.55916245
130MP0005164_abnormal_response_to0.55476439
131MP0004087_abnormal_muscle_fiber0.55147524
132MP0005193_abnormal_anterior_eye0.54655275
133MP0001915_intracranial_hemorrhage0.54587974
134MP0002168_other_aberrant_phenotype0.54489908
135MP0009115_abnormal_fat_cell0.53212579
136MP0003283_abnormal_digestive_organ0.53187645
137MP0002933_joint_inflammation0.52063615
138MP0004185_abnormal_adipocyte_glucose0.51821360
139MP0005464_abnormal_platelet_physiology0.51327470
140MP0002896_abnormal_bone_mineralization0.51165990
141MP0003566_abnormal_cell_adhesion0.51125945
142MP0002128_abnormal_blood_circulation0.50354830
143MP0005248_abnormal_Harderian_gland0.50246472
144MP0009765_abnormal_xenobiotic_induced0.50213426
145MP0004883_abnormal_blood_vessel0.49616576
146MP0002282_abnormal_trachea_morphology0.48760421
147* MP0002078_abnormal_glucose_homeostasis0.48353031
148MP0002928_abnormal_bile_duct0.47447713
149MP0002135_abnormal_kidney_morphology0.46849030
150MP0003638_abnormal_response/metabolism_0.46176276
151MP0005508_abnormal_skeleton_morphology0.44282916
152MP0005395_other_phenotype0.43961019
153MP0002249_abnormal_larynx_morphology0.43862573
154MP0000639_abnormal_adrenal_gland0.41953397
155MP0005390_skeleton_phenotype0.41648910
156MP0002115_abnormal_skeleton_extremities0.40724494
157MP0002970_abnormal_white_adipose0.39912631
158MP0000163_abnormal_cartilage_morphology0.39613935
159MP0006036_abnormal_mitochondrial_physio0.39406706

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.94116741
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.32204802
3Intrahepatic cholestasis (HP:0001406)5.97092082
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.73789150
5Xanthomatosis (HP:0000991)5.69005740
6Prolonged partial thromboplastin time (HP:0003645)5.63875996
7Hypobetalipoproteinemia (HP:0003563)5.22405649
8Vascular tortuosity (HP:0004948)4.87276633
9Hyperlipoproteinemia (HP:0010980)4.80627765
10Complement deficiency (HP:0004431)4.78089550
11Ankle contracture (HP:0006466)4.74438888
12Protrusio acetabuli (HP:0003179)4.39180263
13Joint hemorrhage (HP:0005261)4.32689794
14Arterial tortuosity (HP:0005116)4.31341609
15Hypolipoproteinemia (HP:0010981)4.12891313
16Hyperammonemia (HP:0001987)4.10741848
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.10416468
18Abnormality of the common coagulation pathway (HP:0010990)4.09562889
19Follicular hyperkeratosis (HP:0007502)4.01661948
20Bladder diverticulum (HP:0000015)3.99839347
21Type 1 muscle fiber predominance (HP:0003803)3.99062321
22Spinal rigidity (HP:0003306)3.89275550
23Ketosis (HP:0001946)3.86850974
24Hypoalphalipoproteinemia (HP:0003233)3.85894894
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.79652696
26Atrophic scars (HP:0001075)3.77641443
27Hyperglycinemia (HP:0002154)3.69702525
28Cervical subluxation (HP:0003308)3.69265511
29Fragile skin (HP:0001030)3.63607786
30Abnormality of complement system (HP:0005339)3.62880239
31Epidermoid cyst (HP:0200040)3.62797857
32Wormian bones (HP:0002645)3.62243797
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.61437102
34Abnormality of sulfur amino acid metabolism (HP:0004339)3.60529723
35Hyperglycinuria (HP:0003108)3.59387476
36Abnormality of the intrinsic pathway (HP:0010989)3.58118520
37Abnormality of dentin (HP:0010299)3.57566597
38Abnormality of glycine metabolism (HP:0010895)3.53163826
39Abnormality of serine family amino acid metabolism (HP:0010894)3.53163826
40Shallow orbits (HP:0000586)3.45055606
41Abnormality of methionine metabolism (HP:0010901)3.44625908
42Slender build (HP:0001533)3.40679382
43Abnormality of pyrimidine metabolism (HP:0004353)3.40182126
44Hypoglycemic coma (HP:0001325)3.32478047
45Dilatation of the ascending aorta (HP:0005111)3.29155218
46Fat malabsorption (HP:0002630)3.23195389
47Neonatal short-limb short stature (HP:0008921)3.18539638
48Peritonitis (HP:0002586)3.17128153
49Cerebral aneurysm (HP:0004944)3.14870774
50Hypercholesterolemia (HP:0003124)3.14696737
51Abnormality of fatty-acid metabolism (HP:0004359)3.13108727
52Genu recurvatum (HP:0002816)3.10372450
53Increased variability in muscle fiber diameter (HP:0003557)3.09115284
54Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.96797455
55Delayed CNS myelination (HP:0002188)2.96758224
56Cardiovascular calcification (HP:0011915)2.95229931
57Mildly elevated creatine phosphokinase (HP:0008180)2.94118568
58Premature rupture of membranes (HP:0001788)2.94056030
59Increased connective tissue (HP:0009025)2.93296326
60Myocardial infarction (HP:0001658)2.92699724
61Spondylolisthesis (HP:0003302)2.90355758
62Hepatocellular carcinoma (HP:0001402)2.89574269
63Mitral valve prolapse (HP:0001634)2.88120091
64Mitral stenosis (HP:0001718)2.88041946
65Joint laxity (HP:0001388)2.82731913
66Abnormality of nucleobase metabolism (HP:0010932)2.82401106
67Vascular calcification (HP:0004934)2.74047020
68Hyperbilirubinemia (HP:0002904)2.72925686
69Conjugated hyperbilirubinemia (HP:0002908)2.72490508
70Bowel diverticulosis (HP:0005222)2.68248098
71Abnormality of skeletal muscle fiber size (HP:0012084)2.65959965
72Ketoacidosis (HP:0001993)2.65728787
73Mitral regurgitation (HP:0001653)2.65234743
74Systemic lupus erythematosus (HP:0002725)2.64911374
75Aneurysm (HP:0002617)2.64080801
76Aortic regurgitation (HP:0001659)2.63133262
77Osteolytic defects of the hand bones (HP:0009699)2.62105642
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.62105642
79Hyperextensible skin (HP:0000974)2.61267392
80Abnormality of serum amino acid levels (HP:0003112)2.60561085
81Skin nodule (HP:0200036)2.57111714
82Abnormality of purine metabolism (HP:0004352)2.53510595
83Spontaneous abortion (HP:0005268)2.53141039
84Spastic diplegia (HP:0001264)2.46131121
85Nonimmune hydrops fetalis (HP:0001790)2.45577016
86Elbow flexion contracture (HP:0002987)2.45576407
87Ectopia lentis (HP:0001083)2.45191052
88Wrist flexion contracture (HP:0001239)2.43525258
89Abnormality of the acetabulum (HP:0003170)2.41899544
90Joint stiffness (HP:0001387)2.41806246
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41451486
92Dicarboxylic aciduria (HP:0003215)2.41451486
93Disproportionate tall stature (HP:0001519)2.38266488
94Steatorrhea (HP:0002570)2.36299019
95Wide anterior fontanel (HP:0000260)2.35205271
96Esophageal varix (HP:0002040)2.32199807
97Ulnar bowing (HP:0003031)2.31700194
98Generalized amyotrophy (HP:0003700)2.31078113
99Overgrowth (HP:0001548)2.30624841
100Hypoventilation (HP:0002791)2.30622855
101Glomerulonephritis (HP:0000099)2.30525800
102Metabolic acidosis (HP:0001942)2.29592588
103Amyloidosis (HP:0011034)2.29469802
104Aortic valve stenosis (HP:0001650)2.26579402
105Neonatal onset (HP:0003623)2.24616836
106Achilles tendon contracture (HP:0001771)2.23997072
107Broad metatarsal (HP:0001783)2.21707837
108Opisthotonus (HP:0002179)2.19849259
109Gout (HP:0001997)2.18510955
110Short nail (HP:0001799)2.17010038
111Biconcave vertebral bodies (HP:0004586)2.16408458
112Abnormality of proline metabolism (HP:0010907)2.15829510
113Hydroxyprolinuria (HP:0003080)2.15829510
114Abnormal cartilage morphology (HP:0002763)2.15174355
115Aortic aneurysm (HP:0004942)2.11546029
116Thrombophlebitis (HP:0004418)2.10362328
117Long toe (HP:0010511)2.07625787
118Aortic dissection (HP:0002647)2.06980013
119Coronal craniosynostosis (HP:0004440)2.06731894
120Enlarged kidneys (HP:0000105)2.06486212
121Hemorrhage of the eye (HP:0011885)2.06257634
122Lethargy (HP:0001254)2.04804510
123Breech presentation (HP:0001623)2.04113200
124Protruding ear (HP:0000411)2.03076089
125Round ear (HP:0100830)2.02307750
126Upper limb amyotrophy (HP:0009129)2.01754795
127Distal upper limb amyotrophy (HP:0007149)2.01754795
128Generalized aminoaciduria (HP:0002909)2.00790362
129Gingival bleeding (HP:0000225)2.00265034
130Coxa vara (HP:0002812)2.00084484
131Menorrhagia (HP:0000132)1.99230885
132Lymphangioma (HP:0100764)1.98962990
133Natal tooth (HP:0000695)1.95068816
134Malnutrition (HP:0004395)1.94664044
135Pancreatitis (HP:0001733)1.92758340
136Abnormal delivery (HP:0001787)1.91821078
137Delayed cranial suture closure (HP:0000270)1.90403221
138Camptodactyly of toe (HP:0001836)1.90223571
139Late onset (HP:0003584)1.88944620
140Mild short stature (HP:0003502)1.88545477
141Blue sclerae (HP:0000592)1.88178286
142Rickets (HP:0002748)1.87897073
143Abnormal enzyme/coenzyme activity (HP:0012379)1.87838750
144Proximal tubulopathy (HP:0000114)1.87595252
145Hypertriglyceridemia (HP:0002155)1.86333678
146Inguinal hernia (HP:0000023)1.85922672
147Hypochromic microcytic anemia (HP:0004840)1.83656424
148Distal lower limb amyotrophy (HP:0008944)1.83485972
149Broad face (HP:0000283)1.81032192
150Vertebral compression fractures (HP:0002953)1.80913538
151Nephritis (HP:0000123)1.80146500
152Venous abnormality (HP:0002624)1.79570896
153Irritability (HP:0000737)1.78898062
154Thin bony cortex (HP:0002753)1.78874624
155Hyperacusis (HP:0010780)1.78456388
156Vomiting (HP:0002013)1.77744788
157Distal lower limb muscle weakness (HP:0009053)1.77586718
158Premature skin wrinkling (HP:0100678)1.77499070
159Striae distensae (HP:0001065)1.77445680
160Abnormality of the Achilles tendon (HP:0005109)1.76736593
161Osteoarthritis (HP:0002758)1.76725732
162Thin skin (HP:0000963)1.76642277
163Cholelithiasis (HP:0001081)1.76308410
164Hypophosphatemic rickets (HP:0004912)1.75429679
165Nephrolithiasis (HP:0000787)1.75230460
166Abnormal gallbladder morphology (HP:0012437)1.74084587
167Abnormality of skull ossification (HP:0002703)1.73748070
168Soft skin (HP:0000977)1.73576964
169Recurrent gram-negative bacterial infections (HP:0005420)1.73558343
170Ovoid vertebral bodies (HP:0003300)1.73338375
171Thoracolumbar scoliosis (HP:0002944)1.73157375
172Osteopenia (HP:0000938)1.72764065
173Mucopolysacchariduria (HP:0008155)1.71710414
174Urinary glycosaminoglycan excretion (HP:0003541)1.71710414
175Delayed closure of the anterior fontanelle (HP:0001476)1.71618924
176Deviation of the hallux (HP:0010051)1.70815313
177Redundant skin (HP:0001582)1.67400635
178Emphysema (HP:0002097)1.67028428
179Limb-girdle muscle weakness (HP:0003325)1.66142861
180Hallux valgus (HP:0001822)1.64800739
181Arachnodactyly (HP:0001166)1.64652497
182Turricephaly (HP:0000262)1.64008474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.05517196
2ERN14.91063230
3SIK13.97349748
4KDR3.88200096
5TRIB33.61186444
6FGFR43.54220614
7PKN23.33309019
8TIE13.09727446
9TESK12.83585555
10FLT32.58584262
11EPHA22.16642363
12TGFBR22.11684071
13NTRK12.07768561
14LIMK12.00767391
15LATS11.99188999
16MST1R1.92134917
17PTK61.75087764
18EPHA31.66843283
19NEK91.59799981
20MAP2K31.59756995
21PDGFRA1.58564053
22CDC42BPA1.51163539
23PIK3CG1.46477573
24ICK1.46240170
25TYK21.43307924
26LATS21.42943383
27TGFBR11.40543672
28DDR21.40067973
29PRPF4B1.37924560
30MAP3K101.37509969
31PRKD21.34908810
32RIPK11.31509813
33STK381.31233332
34EPHB11.27165947
35MAPK111.27138996
36INSRR1.22712504
37LMTK21.21675873
38MAP3K61.19331325
39TAOK31.19076226
40EPHB21.17879109
41ABL21.13402479
42ERBB41.10486539
43MAP3K31.10300292
44MAP3K111.08983537
45SMG11.08122298
46BLK1.07216267
47MOS1.07136401
48KIT1.06958327
49MET1.06052070
50DMPK1.05932979
51TTN0.99788441
52GRK50.98853924
53ARAF0.98235785
54TBK10.95646897
55PTK20.93808377
56RPS6KA20.92495136
57CDK60.90146291
58PRKG20.89813130
59PAK40.89674403
60ILK0.89357660
61FER0.84669161
62JAK30.84311343
63PAK20.83880957
64FGFR20.82721873
65JAK20.82647074
66LRRK20.82590679
67JAK10.82526526
68CAMK1D0.80267871
69CDK80.79988542
70ROCK20.79163271
71ADRBK10.78748877
72PRKAA20.78279433
73MAP2K40.78083581
74MAP3K70.77758149
75EEF2K0.74811329
76MYLK0.73379998
77NME20.73228920
78RPS6KA40.72700319
79GRK10.71813056
80TAOK20.69312507
81MAPK40.67778343
82HIPK20.65101566
83ROCK10.64855444
84PTK2B0.63661486
85ERBB20.62821049
86STK38L0.61718053
87GRK60.61607289
88TRPM70.61557119
89FRK0.60740239
90CSK0.60704502
91DAPK30.58292119
92FGFR30.57345517
93AKT30.55226888
94FGFR10.54865985
95TESK20.53727877
96MAPK120.52583619
97ZAP700.52102377
98PRKD30.51633940
99PDPK10.51415932
100RPS6KL10.50971640
101RPS6KC10.50971640
102CSF1R0.50810384
103CDK40.50004900
104GSK3A0.47730195
105DYRK1B0.47484824
106BMX0.46645037
107SCYL20.45491259
108IRAK10.45219035
109PAK10.45209213
110MTOR0.44525459
111CLK10.44458514
112MAP4K10.43810756
113MAP2K10.42619408
114MAPKAPK20.41341022
115IGF1R0.40491142
116MARK20.40187760
117STK30.39910441
118GRK70.38146753
119CAMK2G0.38126551
120RET0.37188252
121MELK0.37111676
122IRAK30.36072919
123BTK0.35384607
124CAMK40.34554755
125NLK0.32231902
126RPS6KA60.31335902
127KSR20.30529177
128MAP3K80.29695672
129SRC0.29274983
130MAPK70.28988891
131MAP3K10.28523047
132MAP3K130.28261510
133PIK3CA0.27367360
134PRKCZ0.26401895
135MAP2K20.26206021
136PRKACG0.25911012
137PIM20.25446794
138MAPKAPK30.24128936
139STK160.22801019
140PRKD10.22544400
141TEC0.22316370
142PDGFRB0.20555354
143STK100.20183254

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.31242890
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.53608860
3Nitrogen metabolism_Homo sapiens_hsa009103.29691729
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12072208
5Arginine biosynthesis_Homo sapiens_hsa002202.95955648
6Complement and coagulation cascades_Homo sapiens_hsa046102.83716518
7Tryptophan metabolism_Homo sapiens_hsa003802.66451265
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61267576
9Fatty acid degradation_Homo sapiens_hsa000712.59024663
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58289523
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48105191
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46519045
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46313648
14Peroxisome_Homo sapiens_hsa041462.07141793
15Butanoate metabolism_Homo sapiens_hsa006502.05354272
16Propanoate metabolism_Homo sapiens_hsa006402.00622411
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99825148
18PPAR signaling pathway_Homo sapiens_hsa033201.99780223
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.95520315
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.92215759
21Chemical carcinogenesis_Homo sapiens_hsa052041.90387411
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85742955
23Fatty acid metabolism_Homo sapiens_hsa012121.83821665
24Histidine metabolism_Homo sapiens_hsa003401.83187753
25beta-Alanine metabolism_Homo sapiens_hsa004101.81037921
26Caffeine metabolism_Homo sapiens_hsa002321.80679930
27Staphylococcus aureus infection_Homo sapiens_hsa051501.79263093
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.77228190
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.70835523
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66003700
31Dilated cardiomyopathy_Homo sapiens_hsa054141.62562892
32Retinol metabolism_Homo sapiens_hsa008301.60650340
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60449128
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.52654782
35Selenocompound metabolism_Homo sapiens_hsa004501.52101632
36Phenylalanine metabolism_Homo sapiens_hsa003601.52030627
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46737378
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46384688
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46210674
40Small cell lung cancer_Homo sapiens_hsa052221.45800510
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44846925
42Bile secretion_Homo sapiens_hsa049761.43212447
43Chronic myeloid leukemia_Homo sapiens_hsa052201.42459211
44Regulation of actin cytoskeleton_Homo sapiens_hsa048101.42414869
45Adherens junction_Homo sapiens_hsa045201.39702877
46Pyruvate metabolism_Homo sapiens_hsa006201.38541732
47Tyrosine metabolism_Homo sapiens_hsa003501.32491519
48Starch and sucrose metabolism_Homo sapiens_hsa005001.32343643
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32212825
50Folate biosynthesis_Homo sapiens_hsa007901.25638281
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.22915244
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.22203533
53Biosynthesis of amino acids_Homo sapiens_hsa012301.20093059
54Carbon metabolism_Homo sapiens_hsa012001.18433504
55Fatty acid elongation_Homo sapiens_hsa000621.14788617
56Leukocyte transendothelial migration_Homo sapiens_hsa046701.12028948
57TGF-beta signaling pathway_Homo sapiens_hsa043501.11696729
58Sulfur metabolism_Homo sapiens_hsa009201.10437230
59Arginine and proline metabolism_Homo sapiens_hsa003301.09233276
60Fat digestion and absorption_Homo sapiens_hsa049751.09156305
61ABC transporters_Homo sapiens_hsa020101.05928776
62Melanoma_Homo sapiens_hsa052181.04422253
63MicroRNAs in cancer_Homo sapiens_hsa052061.03176745
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02954017
65Sulfur relay system_Homo sapiens_hsa041221.01975422
66Notch signaling pathway_Homo sapiens_hsa043301.01640001
67Hippo signaling pathway_Homo sapiens_hsa043901.00720925
68Lysine degradation_Homo sapiens_hsa003100.99812119
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99395566
70Lysosome_Homo sapiens_hsa041420.98699936
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98634421
72Pancreatic cancer_Homo sapiens_hsa052120.97622887
73Pathways in cancer_Homo sapiens_hsa052000.97080652
74Vitamin digestion and absorption_Homo sapiens_hsa049770.92240524
75N-Glycan biosynthesis_Homo sapiens_hsa005100.90402690
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90321003
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89530762
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88086643
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.85119375
80Renal cell carcinoma_Homo sapiens_hsa052110.85052214
81Steroid biosynthesis_Homo sapiens_hsa001000.84785648
82One carbon pool by folate_Homo sapiens_hsa006700.83474926
83Vibrio cholerae infection_Homo sapiens_hsa051100.83413872
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82408319
85Basal cell carcinoma_Homo sapiens_hsa052170.81358578
86Endocytosis_Homo sapiens_hsa041440.80854552
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80181337
88Glioma_Homo sapiens_hsa052140.79426803
89Glutathione metabolism_Homo sapiens_hsa004800.78586436
90TNF signaling pathway_Homo sapiens_hsa046680.78234201
91Shigellosis_Homo sapiens_hsa051310.77810010
92Axon guidance_Homo sapiens_hsa043600.77047349
93Rap1 signaling pathway_Homo sapiens_hsa040150.75963816
94Gap junction_Homo sapiens_hsa045400.75953462
95Prostate cancer_Homo sapiens_hsa052150.75450945
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.73694590
97VEGF signaling pathway_Homo sapiens_hsa043700.73129152
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72765217
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.71835187
100Melanogenesis_Homo sapiens_hsa049160.71458430
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70618632
102Thyroid cancer_Homo sapiens_hsa052160.69651103
103Hedgehog signaling pathway_Homo sapiens_hsa043400.68861833
104Acute myeloid leukemia_Homo sapiens_hsa052210.68606968
105Pentose phosphate pathway_Homo sapiens_hsa000300.68027335
106Tight junction_Homo sapiens_hsa045300.66331328
107Glycerolipid metabolism_Homo sapiens_hsa005610.65226975
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63543046
109Toxoplasmosis_Homo sapiens_hsa051450.62969115
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62874183
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.62440170
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60118268
113Estrogen signaling pathway_Homo sapiens_hsa049150.58981972
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55932282
115HTLV-I infection_Homo sapiens_hsa051660.54247890
116Salmonella infection_Homo sapiens_hsa051320.52779807
117GnRH signaling pathway_Homo sapiens_hsa049120.52484350
118Endometrial cancer_Homo sapiens_hsa052130.51984361
119Platelet activation_Homo sapiens_hsa046110.51920292
120mTOR signaling pathway_Homo sapiens_hsa041500.51798753
121Vitamin B6 metabolism_Homo sapiens_hsa007500.50864427
122Ras signaling pathway_Homo sapiens_hsa040140.49413740
123Hepatitis B_Homo sapiens_hsa051610.48952335
124Apoptosis_Homo sapiens_hsa042100.46207302
125Thyroid hormone synthesis_Homo sapiens_hsa049180.44900994
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.44017353
127HIF-1 signaling pathway_Homo sapiens_hsa040660.43435104
128Metabolic pathways_Homo sapiens_hsa011000.39707723
129Fatty acid biosynthesis_Homo sapiens_hsa000610.36590593
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.32209700
131Insulin resistance_Homo sapiens_hsa049310.31857941
132ECM-receptor interaction_Homo sapiens_hsa045120.31298056
133Galactose metabolism_Homo sapiens_hsa000520.28620682
134Prion diseases_Homo sapiens_hsa050200.27825080
135Protein digestion and absorption_Homo sapiens_hsa049740.22280925
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18877443
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.15226775
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13256026
139Malaria_Homo sapiens_hsa051440.11529267
140Fructose and mannose metabolism_Homo sapiens_hsa000510.10702004
141AMPK signaling pathway_Homo sapiens_hsa041520.10048073
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.06960044
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.05357064
144Glucagon signaling pathway_Homo sapiens_hsa049220.05010968
145Bladder cancer_Homo sapiens_hsa052190.03244326
146Renin-angiotensin system_Homo sapiens_hsa046140.03085082
147Amoebiasis_Homo sapiens_hsa051460.02132698
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01112073
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.00410161
150Proteoglycans in cancer_Homo sapiens_hsa05205-0.1322447
151Hepatitis C_Homo sapiens_hsa05160-0.1308100
152Other glycan degradation_Homo sapiens_hsa00511-0.1193197
153Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.1154827
154Pertussis_Homo sapiens_hsa05133-0.1124468
155Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1012476
156Insulin signaling pathway_Homo sapiens_hsa04910-0.0909373
157PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0847700
158Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0780809
159Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0526412
160Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0244155
161Linoleic acid metabolism_Homo sapiens_hsa00591-0.0161515
162Focal adhesion_Homo sapiens_hsa04510-0.0122290

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