IGFL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the insulin-like growth factor family of signaling molecules. The encoded protein is synthesized as a precursor protein and is proteolytically cleaved to form a secreted mature peptide. The mature peptide binds to a receptor, which in mouse was found on the cell surface of T cells. Increased expression of this gene may be linked to psoriasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.93170386
2bundle of His cell to Purkinje myocyte communication (GO:0086069)8.83109777
3keratinocyte differentiation (GO:0030216)8.62871539
4multicellular organismal water homeostasis (GO:0050891)7.26086299
5peptide cross-linking (GO:0018149)7.12745960
6keratinocyte proliferation (GO:0043616)6.85943359
7epidermal cell differentiation (GO:0009913)6.73534321
8negative regulation of keratinocyte proliferation (GO:0010839)6.33910311
9epidermis development (GO:0008544)5.96658658
10water homeostasis (GO:0030104)5.90929801
11gap junction assembly (GO:0016264)5.52162122
12skin morphogenesis (GO:0043589)5.46792745
13citrulline biosynthetic process (GO:0019240)5.37944550
14surfactant homeostasis (GO:0043129)5.06517280
15hair cycle (GO:0042633)4.74811694
16molting cycle (GO:0042303)4.74811694
17negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.64558659
18ectoderm development (GO:0007398)4.62940490
19lipoxygenase pathway (GO:0019372)4.58922165
20positive regulation of epidermal cell differentiation (GO:0045606)4.44052887
21establishment of planar polarity (GO:0001736)4.36463676
22establishment of tissue polarity (GO:0007164)4.36463676
23cell-substrate junction assembly (GO:0007044)4.35380710
24dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.34497037
25positive regulation of keratinocyte differentiation (GO:0045618)4.32550152
26positive regulation of epidermis development (GO:0045684)4.24585815
27long-chain fatty acid biosynthetic process (GO:0042759)4.22649816
28regulation of keratinocyte proliferation (GO:0010837)4.13766610
29chemical homeostasis within a tissue (GO:0048875)4.10512639
30regulation of keratinocyte differentiation (GO:0045616)4.09422507
31citrulline metabolic process (GO:0000052)3.99577613
32cardiac right ventricle morphogenesis (GO:0003215)3.82118025
33keratinocyte development (GO:0003334)3.80212865
34intestinal epithelial cell development (GO:0060576)3.71540234
35epithelial cell-cell adhesion (GO:0090136)3.58795219
36eyelid development in camera-type eye (GO:0061029)3.48528644
37planar cell polarity pathway involved in neural tube closure (GO:0090179)3.46604611
38negative regulation of interferon-gamma production (GO:0032689)3.45924337
39detection of bacterium (GO:0016045)3.45180040
40intermediate filament organization (GO:0045109)3.44208693
41cell adhesion mediated by integrin (GO:0033627)3.41766870
42regulation of transforming growth factor beta2 production (GO:0032909)3.39181421
43polarized epithelial cell differentiation (GO:0030859)3.36060633
44regulation of epidermis development (GO:0045682)3.34907836
45regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.31944687
46linoleic acid metabolic process (GO:0043651)3.31313944
47positive regulation of monocyte chemotaxis (GO:0090026)3.29730013
48regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.28740620
49peptidyl-arginine modification (GO:0018195)3.28243984
50regulation of epidermal cell differentiation (GO:0045604)3.23905634
51protein localization to microtubule (GO:0035372)3.20929697
52diterpenoid biosynthetic process (GO:0016102)3.12026859
53intermediate filament cytoskeleton organization (GO:0045104)3.11983002
54cellular response to vitamin D (GO:0071305)3.10103605
55detection of other organism (GO:0098543)3.05925572
56regulation of natural killer cell differentiation (GO:0032823)3.04942173
57ventricular cardiac muscle cell action potential (GO:0086005)3.04488512
58branching involved in mammary gland duct morphogenesis (GO:0060444)3.03420495
59regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.02527170
60hypotonic response (GO:0006971)3.02488899
61epithelium development (GO:0060429)3.01809206
62regulation of cardioblast differentiation (GO:0051890)2.98829435
63ribosomal small subunit biogenesis (GO:0042274)2.98578691
64intermediate filament-based process (GO:0045103)2.98392619
65G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.95584633
66negative regulation of cell fate specification (GO:0009996)2.92788555
67negative regulation of chondrocyte differentiation (GO:0032331)2.91140850
68activation of Rac GTPase activity (GO:0032863)2.89089095
69phosphatidylserine acyl-chain remodeling (GO:0036150)2.88720273
70skin development (GO:0043588)2.85089893
71regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.83021918
72epithelial cell differentiation involved in prostate gland development (GO:0060742)2.79366118
73positive regulation of Cdc42 GTPase activity (GO:0043089)2.78290582
74positive regulation of hair follicle development (GO:0051798)2.75730378
75positive regulation of hair cycle (GO:0042635)2.75730378
76mammary gland epithelial cell proliferation (GO:0033598)2.73452221
77regulation of hair follicle development (GO:0051797)2.72960804
78atrioventricular valve morphogenesis (GO:0003181)2.72175391
79negative regulation of stem cell proliferation (GO:2000647)2.70505833
80ear development (GO:0043583)2.65539442
81chronic inflammatory response (GO:0002544)2.65348292
82protein localization to endosome (GO:0036010)2.64721016
83COPI coating of Golgi vesicle (GO:0048205)2.59350016
84Golgi transport vesicle coating (GO:0048200)2.59350016
85lateral sprouting from an epithelium (GO:0060601)2.56662772
86cell differentiation involved in embryonic placenta development (GO:0060706)2.54919529
87negative regulation of protein tyrosine kinase activity (GO:0061099)2.54008774
88regulation of heart rate by cardiac conduction (GO:0086091)2.51516080
89cyclooxygenase pathway (GO:0019371)2.48575621
90viral transcription (GO:0019083)2.48394592
91regulation of hair cycle (GO:0042634)2.48022589
92mesodermal cell differentiation (GO:0048333)2.47992600
93cell junction organization (GO:0034330)2.47783192
94morphogenesis of embryonic epithelium (GO:0016331)2.47297970
95negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.47092797
96response to vitamin D (GO:0033280)2.44816681
97keratinization (GO:0031424)16.1387782
98desmosome organization (GO:0002934)12.7078554
99establishment of skin barrier (GO:0061436)12.0150044
100regulation of water loss via skin (GO:0033561)10.8899760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.06852887
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human5.15031653
3* ESR2_21235772_ChIP-Seq_MCF-7_Human3.45173739
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.28807555
5SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.27414594
6SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.27414594
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.05284241
8RARG_19884340_ChIP-ChIP_MEFs_Mouse3.02633224
9P63_26484246_Chip-Seq_KERATINOCYTES_Human3.00588597
10TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.66899783
11ZNF263_19887448_ChIP-Seq_K562_Human2.52783006
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.51138155
13KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.39517584
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.39345004
15PPAR_26484153_Chip-Seq_NCI-H1993_Human2.15736167
16* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.12762882
17ATF3_27146783_Chip-Seq_COLON_Human2.09655167
18TP63_17297297_ChIP-ChIP_HaCaT_Human13.2087522
19SOX2_20726797_ChIP-Seq_SW620_Human1.96116304
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92906488
21RACK7_27058665_Chip-Seq_MCF-7_Human1.92364666
22RUNX1_27514584_Chip-Seq_MCF-7_Human1.83899874
23SOX9_24532713_ChIP-Seq_HFSC_Mouse1.80774275
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72265699
25ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.68353325
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.62129647
27SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.61876452
28KLF5_25053715_ChIP-Seq_YYC3_Human1.58439502
29AHR_22903824_ChIP-Seq_MCF-7_Human1.54427588
30GATA3_24758297_ChIP-Seq_MCF-7_Human1.54427254
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.49087431
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.43276312
33FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.42826414
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40291641
35TP63_22573176_ChIP-Seq_HFKS_Human1.38017279
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37439656
37TP63_23658742_ChIP-Seq_EP156T_Human1.37346792
38UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35836248
39GATA6_25053715_ChIP-Seq_YYC3_Human1.35295123
40UBF1/2_26484160_Chip-Seq_HMECs_Human1.34484761
41CLOCK_20551151_ChIP-Seq_293T_Human1.31182424
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27510436
43HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24641359
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.24630486
45CJUN_26792858_Chip-Seq_BT549_Human1.24186215
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20539827
47AR_21909140_ChIP-Seq_LNCAP_Human1.20381497
48ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18510645
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15346177
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14920791
51JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14028797
52EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12391732
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12371964
54JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11076940
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10837589
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10530171
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.09808971
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08547986
59LXR_22292898_ChIP-Seq_THP-1_Human1.08466362
60ELF5_23300383_ChIP-Seq_T47D_Human1.04010519
61* GATA4_25053715_ChIP-Seq_YYC3_Human1.03770895
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03112508
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02756514
64TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96967387
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95675235
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95639219
67NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95413841
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94142215
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89157846
70KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87568619
71TCF4_18268006_ChIP-ChIP_LS174T_Human0.87425797
72TP53_18474530_ChIP-ChIP_U2OS_Human0.86237281
73SMC4_20622854_ChIP-Seq_HELA_Human0.84684755
74FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84275057
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84225276
76ERG_21242973_ChIP-ChIP_JURKAT_Human0.82176323
77CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81981439
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81743207
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78017742
80BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76153179
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74788391
82TBX20_22328084_ChIP-Seq_HEART_Mouse0.73388007
83TBX20_22080862_ChIP-Seq_HEART_Mouse0.73388007
84ELK1_22589737_ChIP-Seq_MCF10A_Human0.73070459
85TP53_22127205_ChIP-Seq_IMR90_Human0.70417984
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.69477020
87ESR1_15608294_ChIP-ChIP_MCF-7_Human0.67888093
88CTCF_27219007_Chip-Seq_Bcells_Human0.65962926
89CREB1_26743006_Chip-Seq_LNCaP_Human0.63847201
90GATA2_21666600_ChIP-Seq_HMVEC_Human0.62683732
91MYC_18555785_ChIP-Seq_MESCs_Mouse0.62408980
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.61753325
93E2F1_20622854_ChIP-Seq_HELA_Human0.61617231
94DNAJC2_21179169_ChIP-ChIP_NT2_Human0.61614474
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.60992406
96NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.60732375
97EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.59919731
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.58655764
99GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.57902248
100* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.56912730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.77220958
2MP0000579_abnormal_nail_morphology6.32434915
3MP0010234_abnormal_vibrissa_follicle5.69681753
4MP0005501_abnormal_skin_physiology4.77149531
5MP0005275_abnormal_skin_tensile4.15279721
6MP0003941_abnormal_skin_development3.69249603
7MP0003453_abnormal_keratinocyte_physiol3.43973165
8MP0001216_abnormal_epidermal_layer3.24428792
9MP0010678_abnormal_skin_adnexa3.02148494
10MP0000467_abnormal_esophagus_morphology2.89076626
11MP0003705_abnormal_hypodermis_morpholog2.80714121
12MP0002060_abnormal_skin_morphology2.80167549
13MP0002098_abnormal_vibrissa_morphology2.63904375
14MP0003566_abnormal_cell_adhesion2.61588047
15MP0010771_integument_phenotype2.60405870
16MP0000383_abnormal_hair_follicle2.55855190
17MP0000762_abnormal_tongue_morphology2.51752867
18MP0004264_abnormal_extraembryonic_tissu2.48075720
19MP0005409_darkened_coat_color2.22219723
20MP0000377_abnormal_hair_follicle2.19634847
21MP0003191_abnormal_cellular_cholesterol2.10300803
22MP0004885_abnormal_endolymph1.89176903
23MP0004782_abnormal_surfactant_physiolog1.82733085
24MP0010352_gastrointestinal_tract_polyps1.80455658
25MP0000566_synostosis1.77161780
26MP0009053_abnormal_anal_canal1.74132566
27MP0004947_skin_inflammation1.72673390
28MP0004185_abnormal_adipocyte_glucose1.72406095
29MP0004381_abnormal_hair_follicle1.69337929
30MP0005023_abnormal_wound_healing1.59914431
31MP0009931_abnormal_skin_appearance1.44945158
32MP0003878_abnormal_ear_physiology1.40898119
33MP0005377_hearing/vestibular/ear_phenot1.40898119
34MP0001849_ear_inflammation1.35077788
35MP0000427_abnormal_hair_cycle1.31323272
36MP0000678_abnormal_parathyroid_gland1.28028238
37MP0001851_eye_inflammation1.24969431
38MP0005248_abnormal_Harderian_gland1.22985388
39MP0001191_abnormal_skin_condition1.22095399
40MP0000537_abnormal_urethra_morphology1.16220592
41MP0002234_abnormal_pharynx_morphology1.13793182
42MP0005076_abnormal_cell_differentiation1.12070308
43MP0000367_abnormal_coat/_hair1.10924001
44MP0000627_abnormal_mammary_gland1.10127773
45MP0003315_abnormal_perineum_morphology1.06151425
46MP0004272_abnormal_basement_membrane1.04049536
47MP0009780_abnormal_chondrocyte_physiolo1.03401623
48MP0000465_gastrointestinal_hemorrhage0.99920682
49MP0010030_abnormal_orbit_morphology0.98123531
50MP0000647_abnormal_sebaceous_gland0.90717616
51MP0001340_abnormal_eyelid_morphology0.90381742
52MP0005666_abnormal_adipose_tissue0.89953353
53MP0003806_abnormal_nucleotide_metabolis0.89302778
54MP0000858_altered_metastatic_potential0.89157346
55MP0002877_abnormal_melanocyte_morpholog0.78462467
56MP0008260_abnormal_autophagy0.71988304
57MP0009379_abnormal_foot_pigmentation0.66649457
58MP0005375_adipose_tissue_phenotype0.64594282
59MP0001243_abnormal_dermal_layer0.63418729
60MP0003755_abnormal_palate_morphology0.63037849
61MP0002139_abnormal_hepatobiliary_system0.61980349
62MP0005408_hypopigmentation0.58451324
63MP0004197_abnormal_fetal_growth/weight/0.57966767
64MP0005193_abnormal_anterior_eye0.57863386
65MP0001873_stomach_inflammation0.57090306
66MP0002006_tumorigenesis0.53629601
67MP0001784_abnormal_fluid_regulation0.52713126
68MP0006138_congestive_heart_failure0.51069445
69MP0000470_abnormal_stomach_morphology0.49878554
70MP0005257_abnormal_intraocular_pressure0.49599783
71MP0005451_abnormal_body_composition0.48804779
72MP0001984_abnormal_olfaction0.48223322
73MP0004957_abnormal_blastocyst_morpholog0.47158105
74MP0008789_abnormal_olfactory_epithelium0.45542483
75MP0002697_abnormal_eye_size0.44835210
76MP0000750_abnormal_muscle_regeneration0.44731581
77MP0002282_abnormal_trachea_morphology0.44682969
78MP0003638_abnormal_response/metabolism_0.41763413
79MP0000013_abnormal_adipose_tissue0.40678209
80MP0002086_abnormal_extraembryonic_tissu0.40659535
81MP0000003_abnormal_adipose_tissue0.40229280
82MP0004858_abnormal_nervous_system0.39848261
83MP0005164_abnormal_response_to0.39703871
84MP0003091_abnormal_cell_migration0.38653458
85MP0000613_abnormal_salivary_gland0.38566632
86MP0001881_abnormal_mammary_gland0.38443743
87MP0002095_abnormal_skin_pigmentation0.38053823
88MP0002089_abnormal_postnatal_growth/wei0.36945751
89MP0002111_abnormal_tail_morphology0.36605309
90MP0008932_abnormal_embryonic_tissue0.36227149
91MP0004019_abnormal_vitamin_homeostasis0.35704391
92MP0004043_abnormal_pH_regulation0.34871882
93MP0000462_abnormal_digestive_system0.34079091
94MP0003950_abnormal_plasma_membrane0.33787311
95MP0009384_cardiac_valve_regurgitation0.32405566
96MP0005670_abnormal_white_adipose0.30559802
97MP0001661_extended_life_span0.30133143
98MP0005197_abnormal_uvea_morphology0.29114329
99MP0005621_abnormal_cell_physiology0.29039252
100MP0001186_pigmentation_phenotype0.28868491

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)8.06058060
2Plantar hyperkeratosis (HP:0007556)6.71145330
3Palmoplantar hyperkeratosis (HP:0000972)6.43087762
4Alopecia of scalp (HP:0002293)6.35332758
5Palmar hyperkeratosis (HP:0010765)6.08150751
6Right ventricular cardiomyopathy (HP:0011663)5.82163286
7Congenital ichthyosiform erythroderma (HP:0007431)5.79390548
8Oral leukoplakia (HP:0002745)5.66713432
9Fragile nails (HP:0001808)5.51790407
10Thick nail (HP:0001805)5.31001201
11Nail dystrophy (HP:0008404)5.21208380
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.20739324
13Hypotrichosis (HP:0001006)5.12187152
14Milia (HP:0001056)5.11314137
15Erythema (HP:0010783)4.92270660
16Corneal erosion (HP:0200020)4.81699083
17Erythroderma (HP:0001019)4.69957237
18Lip pit (HP:0100267)4.65687095
19Increased IgE level (HP:0003212)4.26092000
20Abnormality of the axillary hair (HP:0100134)4.14973934
21Abnormality of secondary sexual hair (HP:0009888)4.14973934
22Parakeratosis (HP:0001036)3.96745066
23Ectropion (HP:0000656)3.94621219
24Sparse eyelashes (HP:0000653)3.88939935
25Atrophic scars (HP:0001075)3.74640088
26Pili torti (HP:0003777)3.68604890
27Ridged nail (HP:0001807)3.68329574
28Woolly hair (HP:0002224)3.64468977
29Absent eyelashes (HP:0000561)3.59288881
30Abnormal blistering of the skin (HP:0008066)3.56209978
31Amniotic constriction ring (HP:0009775)3.55727822
32Abnormality of placental membranes (HP:0011409)3.55727822
33Palmoplantar keratoderma (HP:0000982)3.44739200
34Selective tooth agenesis (HP:0001592)3.36287511
35Abnormal hair laboratory examination (HP:0003328)3.25203289
36Hypohidrosis (HP:0000966)3.13871962
37Abnormality of the salivary glands (HP:0010286)3.05884429
38Sparse scalp hair (HP:0002209)2.94276058
39Absent hair (HP:0002298)2.85081543
40Pterygium (HP:0001059)2.80616197
41Blepharitis (HP:0000498)2.68776750
42Pustule (HP:0200039)2.68314782
43Septate vagina (HP:0001153)2.62922658
44Fragile skin (HP:0001030)2.58650886
45Hypoplasia of dental enamel (HP:0006297)2.56013433
46Oligodontia (HP:0000677)2.51820641
47Multifactorial inheritance (HP:0001426)2.49062931
48Dehydration (HP:0001944)2.47397833
49Popliteal pterygium (HP:0009756)2.39891256
50Abnormality of the gastric mucosa (HP:0004295)2.39512548
51Ankyloglossia (HP:0010296)2.37294582
52Aplasia cutis congenita (HP:0001057)2.32763083
53Brittle hair (HP:0002299)2.29031358
54Hypoplastic labia majora (HP:0000059)2.28521310
55Anonychia (HP:0001798)2.21287004
56Autoamputation (HP:0001218)2.16864286
57Acanthosis nigricans (HP:0000956)2.13052941
58Carious teeth (HP:0000670)2.11109236
59Gangrene (HP:0100758)2.09024371
60Natal tooth (HP:0000695)2.06815117
61Abnormality of the labia majora (HP:0012881)2.05169508
62Advanced eruption of teeth (HP:0006288)2.03178262
63Conjugated hyperbilirubinemia (HP:0002908)2.03166518
64Trismus (HP:0000211)2.01414721
65Abnormality of nail color (HP:0100643)10.2623221
66Abnormality of oral frenula (HP:0000190)1.96526051
67Breast hypoplasia (HP:0003187)1.86356008
68Pruritus (HP:0000989)1.86130708
69Lack of skin elasticity (HP:0100679)1.84836478
70Hyperhidrosis (HP:0000975)1.84034169
71Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.83316074
72Squamous cell carcinoma (HP:0002860)1.81517369
73Furrowed tongue (HP:0000221)1.80246364
74Nasolacrimal duct obstruction (HP:0000579)1.79909199
75Hypoplastic toenails (HP:0001800)1.79838519
76Broad face (HP:0000283)1.77300378
77Ventricular tachycardia (HP:0004756)1.76695124
78Curly hair (HP:0002212)1.75919675
79Abnormality of the fingernails (HP:0001231)1.74516364
80Hyperactive renin-angiotensin system (HP:0000841)1.72214116
81Slow-growing hair (HP:0002217)1.69798962
82Abnormality of hair growth rate (HP:0011363)1.69798962
83Split foot (HP:0001839)1.68514111
84Distal lower limb muscle weakness (HP:0009053)1.67464741
85Elfin facies (HP:0004428)1.66047750
86Recurrent corneal erosions (HP:0000495)1.65251675
87Arterial tortuosity (HP:0005116)1.65181287
88Hyperacusis (HP:0010780)1.64168169
89Amelogenesis imperfecta (HP:0000705)1.60704835
90Laryngomalacia (HP:0001601)1.60602859
91Abnormalities of placenta or umbilical cord (HP:0001194)1.60282613
92Dry skin (HP:0000958)1.56401902
93Cheilitis (HP:0100825)1.54069793
94Palpitations (HP:0001962)1.51639464
95Skin pits (HP:0100276)1.49130601
96Xerostomia (HP:0000217)1.47369585
97Fine hair (HP:0002213)1.46000476
98Abnormality of the dental root (HP:0006486)1.45006098
99Taurodontia (HP:0000679)1.45006098
100Abnormality of permanent molar morphology (HP:0011071)1.45006098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.28015307
2MST1R5.44596927
3MET3.60698373
4EPHB23.59627872
5TRIB33.23942236
6IRAK33.23863742
7MAP3K123.00548095
8MAP3K92.83148727
9NME22.37389955
10ERN12.32278934
11STK242.01970508
12ARAF1.93560351
13PTK21.90734849
14PAK41.85044621
15SIK11.81569063
16MAP3K21.80677079
17MAPKAPK31.77649256
18RPS6KB21.76069784
19LATS21.62480828
20TGFBR11.56165725
21NTRK11.52207745
22PKN21.51197913
23PIK3CA1.47347695
24MST41.46132430
25PIM21.37480221
26PDGFRA1.33257323
27TESK11.32322907
28MAP3K31.31668528
29RIPK11.30090202
30FLT31.26053504
31TTN1.25500505
32ILK1.25394777
33FER1.05582597
34BMX1.05227838
35SMG11.03834380
36CDK120.98592409
37CDK80.94452938
38LMTK20.89996248
39SCYL20.87838530
40EIF2AK10.87410369
41LRRK20.86491914
42PBK0.85761296
43MYLK0.83292471
44NEK60.83053588
45PTK60.80325070
46CDK90.69540166
47DMPK0.67040238
48PRKCI0.66444456
49BRAF0.58191811
50EPHB10.57134103
51TRPM70.56835820
52STK100.55626627
53IRAK20.55334357
54NME10.55215267
55MUSK0.55167832
56LATS10.53901496
57IKBKB0.52926753
58CHUK0.51130859
59MTOR0.50153758
60MELK0.50080826
61GRK60.49629696
62NEK10.48933766
63MAP3K60.42460415
64ABL20.40855037
65TGFBR20.40221636
66LIMK10.39080902
67DAPK30.38256444
68CAMK2G0.37239846
69MAPKAPK20.35189761
70RPS6KA20.34672529
71EIF2AK30.33203892
72MAP2K10.32968826
73ERBB40.31500841
74MAP3K10.31357036
75AURKA0.30601045
76DAPK10.30263183
77ROCK20.29503659
78STK30.29470965
79PDGFRB0.28854420
80MAP3K130.26478352
81IRAK40.26341208
82RET0.26219784
83MAP2K20.25560808
84ROCK10.24996179
85BLK0.24836746
86PRPF4B0.24543668
87AURKB0.24371874
88RPS6KB10.24228449
89STK38L0.23902826
90RPS6KL10.23476777
91RPS6KC10.23476777
92TAOK10.22917464
93CAMK2B0.22343173
94EIF2AK20.21447830
95KSR10.20606074
96FGFR40.20280410
97IRAK10.19382673
98MAP3K70.19226100
99MAP3K80.19047888
100CDK70.18442033

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.81435419
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.76227296
3Adherens junction_Homo sapiens_hsa045202.48904893
4ECM-receptor interaction_Homo sapiens_hsa045122.34184901
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.21826732
6Small cell lung cancer_Homo sapiens_hsa052222.20950176
7ErbB signaling pathway_Homo sapiens_hsa040121.95779461
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95484393
9Thyroid cancer_Homo sapiens_hsa052161.93290339
10Circadian rhythm_Homo sapiens_hsa047101.90618028
11VEGF signaling pathway_Homo sapiens_hsa043701.73855402
12Chronic myeloid leukemia_Homo sapiens_hsa052201.73185621
13Renal cell carcinoma_Homo sapiens_hsa052111.72663786
14Amoebiasis_Homo sapiens_hsa051461.72092570
15Arachidonic acid metabolism_Homo sapiens_hsa005901.71550285
16Bladder cancer_Homo sapiens_hsa052191.69185466
17Proteoglycans in cancer_Homo sapiens_hsa052051.62714696
18Galactose metabolism_Homo sapiens_hsa000521.59976562
19Focal adhesion_Homo sapiens_hsa045101.58065454
20Tight junction_Homo sapiens_hsa045301.56266182
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51751047
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46854095
23Hippo signaling pathway_Homo sapiens_hsa043901.45531178
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.42213201
25Phenylalanine metabolism_Homo sapiens_hsa003601.40212716
26Pancreatic cancer_Homo sapiens_hsa052121.39489118
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38754510
28Notch signaling pathway_Homo sapiens_hsa043301.38519630
29Acute myeloid leukemia_Homo sapiens_hsa052211.25604590
30Fructose and mannose metabolism_Homo sapiens_hsa000511.23828204
31Glioma_Homo sapiens_hsa052141.19165449
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17843280
33Axon guidance_Homo sapiens_hsa043601.17190766
34MicroRNAs in cancer_Homo sapiens_hsa052061.16109013
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16105692
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15503252
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.14932143
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12457865
39Vibrio cholerae infection_Homo sapiens_hsa051101.10836797
40Ether lipid metabolism_Homo sapiens_hsa005651.09739532
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.08550602
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04913841
43Choline metabolism in cancer_Homo sapiens_hsa052311.03581946
44Endocytosis_Homo sapiens_hsa041441.03179674
45p53 signaling pathway_Homo sapiens_hsa041151.02326072
46Insulin signaling pathway_Homo sapiens_hsa049101.01989278
47GnRH signaling pathway_Homo sapiens_hsa049121.01335198
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.93124170
49Linoleic acid metabolism_Homo sapiens_hsa005910.93116381
50Pathways in cancer_Homo sapiens_hsa052000.92852877
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91303498
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90888014
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90412492
54Retinol metabolism_Homo sapiens_hsa008300.90237760
55Endometrial cancer_Homo sapiens_hsa052130.90038533
56Shigellosis_Homo sapiens_hsa051310.89560995
57Pentose phosphate pathway_Homo sapiens_hsa000300.87552760
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.86938454
59TGF-beta signaling pathway_Homo sapiens_hsa043500.86064279
60Hepatitis C_Homo sapiens_hsa051600.84667762
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83211831
62Dilated cardiomyopathy_Homo sapiens_hsa054140.82366767
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79324358
64Ovarian steroidogenesis_Homo sapiens_hsa049130.77466165
65Sphingolipid metabolism_Homo sapiens_hsa006000.74984351
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73324489
67Salmonella infection_Homo sapiens_hsa051320.72467992
68Inositol phosphate metabolism_Homo sapiens_hsa005620.70336601
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70111324
70Steroid biosynthesis_Homo sapiens_hsa001000.69296001
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68499386
72HIF-1 signaling pathway_Homo sapiens_hsa040660.66943673
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64545279
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64285899
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64176400
76Histidine metabolism_Homo sapiens_hsa003400.63535023
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.62790955
78Non-small cell lung cancer_Homo sapiens_hsa052230.58046997
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.57879697
80N-Glycan biosynthesis_Homo sapiens_hsa005100.54565288
81Estrogen signaling pathway_Homo sapiens_hsa049150.52488126
82Apoptosis_Homo sapiens_hsa042100.50831444
83Sulfur metabolism_Homo sapiens_hsa009200.50632538
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49603619
85Toxoplasmosis_Homo sapiens_hsa051450.47808262
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45936068
87Alzheimers disease_Homo sapiens_hsa050100.45297480
88Starch and sucrose metabolism_Homo sapiens_hsa005000.44404171
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.44145905
90Chemical carcinogenesis_Homo sapiens_hsa052040.43604890
91Arginine biosynthesis_Homo sapiens_hsa002200.43533824
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42880240
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42013444
94mTOR signaling pathway_Homo sapiens_hsa041500.42008603
95Rap1 signaling pathway_Homo sapiens_hsa040150.40780545
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.40747585
97Tyrosine metabolism_Homo sapiens_hsa003500.39538664
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38962630
99Basal cell carcinoma_Homo sapiens_hsa052170.38884420
100Melanogenesis_Homo sapiens_hsa049160.38125313

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