ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	polyketide metabolic process (GO:0030638)	7.25155395
2	doxorubicin metabolic process (GO:0044598)	7.25155395
3	daunorubicin metabolic process (GO:0044597)	7.25155395
4	desmosome organization (GO:0002934)	7.16636812
5	aminoglycoside antibiotic metabolic process (GO:0030647)	6.40153648
6	hemidesmosome assembly (GO:0031581)	6.14820120
7	regulation of translational fidelity (GO:0006450)	5.33599148
8	Golgi transport vesicle coating (GO:0048200)	5.05224401
9	COPI coating of Golgi vesicle (GO:0048205)	5.05224401
10	glucose 6-phosphate metabolic process (GO:0051156)	4.41699851
11	folic acid metabolic process (GO:0046655)	4.19047756
12	apical protein localization (GO:0045176)	4.16926401
13	L-serine transport (GO:0015825)	4.00721694
14	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.95803768
15	terpenoid biosynthetic process (GO:0016114)	3.94754952
16	nuclear pore complex assembly (GO:0051292)	3.76860354
17	pentose-phosphate shunt (GO:0006098)	3.75441282
18	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.68519163
19	NADPH regeneration (GO:0006740)	3.66968160
20	asymmetric protein localization (GO:0008105)	3.60090811
21	glycoside metabolic process (GO:0016137)	3.55030481
22	glucose catabolic process (GO:0006007)	3.51598837
23	inositol metabolic process (GO:0006020)	3.49263057
24	diterpenoid biosynthetic process (GO:0016102)	3.48250845
25	midgut development (GO:0007494)	3.48094994
26	nuclear pore organization (GO:0006999)	3.34447417
27	protein retention in ER lumen (GO:0006621)	3.34028021
28	formation of translation preinitiation complex (GO:0001731)	3.28109065
29	cell-substrate junction assembly (GO:0007044)	3.22710160
30	serine transport (GO:0032329)	3.19361846
31	proline biosynthetic process (GO:0006561)	3.18761922
32	mitotic chromosome condensation (GO:0007076)	3.16664440
33	activation of Rac GTPase activity (GO:0032863)	3.09249673
34	cellular protein complex localization (GO:0034629)	3.07144447
35	homocysteine metabolic process (GO:0050667)	3.05072846
36	regulation of cholesterol biosynthetic process (GO:0045540)	2.99087142
37	regulation of translational elongation (GO:0006448)	2.98610891
38	positive regulation of osteoblast proliferation (GO:0033690)	2.97746407
39	nuclear envelope reassembly (GO:0031468)	2.94483840
40	mitotic nuclear envelope reassembly (GO:0007084)	2.94483840
41	pore complex assembly (GO:0046931)	2.89345250
42	primary alcohol catabolic process (GO:0034310)	2.88956966
43	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.88092751
44	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	2.87225107
45	folic acid-containing compound metabolic process (GO:0006760)	2.86355987
46	atrioventricular valve morphogenesis (GO:0003181)	2.85596134
47	cellular response to ammonium ion (GO:0071242)	2.84945993
48	tRNA aminoacylation for protein translation (GO:0006418)	2.82598412
49	erythrocyte maturation (GO:0043249)	2.79479366
50	cholesterol biosynthetic process (GO:0006695)	2.78302929
51	pentose metabolic process (GO:0019321)	2.77917371
52	epithelial cell-cell adhesion (GO:0090136)	2.75298358
53	regulation of histone H3-K27 methylation (GO:0061085)	2.71576193
54	establishment of apical/basal cell polarity (GO:0035089)	2.70947701
55	morphogenesis of embryonic epithelium (GO:0016331)	2.69855280
56	nucleobase-containing small molecule interconversion (GO:0015949)	2.69811554
57	tRNA aminoacylation (GO:0043039)	2.69708860
58	amino acid activation (GO:0043038)	2.69708860
59	mRNA cleavage (GO:0006379)	2.66431189
60	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.66375760
61	aggressive behavior (GO:0002118)	2.66181276
62	protein localization to microtubule (GO:0035372)	2.62674211
63	folic acid-containing compound biosynthetic process (GO:0009396)	2.61709401
64	membrane budding (GO:0006900)	2.61619985
65	protein complex localization (GO:0031503)	2.59824380
66	focal adhesion assembly (GO:0048041)	2.59310145
67	cell-substrate adherens junction assembly (GO:0007045)	2.59310145
68	ribosome biogenesis (GO:0042254)	2.57691783
69	viral mRNA export from host cell nucleus (GO:0046784)	2.55945502
70	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.54476104
71	DNA replication checkpoint (GO:0000076)	2.54346877
72	neutral amino acid transport (GO:0015804)	2.54069731
73	GDP-mannose metabolic process (GO:0019673)	2.52079956
74	regulation of early endosome to late endosome transport (GO:2000641)	2.50422301
75	meiotic chromosome segregation (GO:0045132)	2.50340544
76	gap junction assembly (GO:0016264)	2.48995278
77	retinal metabolic process (GO:0042574)	2.48910848
78	L-serine metabolic process (GO:0006563)	2.47632700
79	DNA unwinding involved in DNA replication (GO:0006268)	2.46603721
80	DNA replication initiation (GO:0006270)	2.45866258
81	snRNA metabolic process (GO:0016073)	2.44909936
82	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.44802926
83	response to vitamin A (GO:0033189)	2.43578592
84	tetrahydrofolate metabolic process (GO:0046653)	2.41920430
85	response to water (GO:0009415)	2.41702754
86	activation of signaling protein activity involved in unfolded protein response (GO:0006987)	2.41245636
87	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.39839589
88	cell adhesion mediated by integrin (GO:0033627)	2.38970566
89	mitotic sister chromatid segregation (GO:0000070)	2.38293363
90	positive regulation of keratinocyte differentiation (GO:0045618)	2.38216033
91	receptor catabolic process (GO:0032801)	2.37616466
92	iron ion import (GO:0097286)	2.37388238
93	vesicle coating (GO:0006901)	2.36535189
94	protein autoprocessing (GO:0016540)	2.36346056
95	branching involved in salivary gland morphogenesis (GO:0060445)	2.36091496
96	isoprenoid biosynthetic process (GO:0008299)	2.34413882
97	positive regulation of nuclease activity (GO:0032075)	2.32951430
98	regulation of mitotic spindle organization (GO:0060236)	2.31844398
99	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.31445371
100	response to food (GO:0032094)	2.31125050

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	5.80269700
2	ZNF263_19887448_ChIP-Seq_K562_Human	5.15632097
3	E2F7_22180533_ChIP-Seq_HELA_Human	5.10043653
4	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.72081143
5	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.61661676
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.61523055
7	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.37142973
8	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.34406222
9	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.15936421
10	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.05431325
11	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.04247094
12	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.01145924
13	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.98389158
14	DCP1A_22483619_ChIP-Seq_HELA_Human	1.95751857
15	RACK7_27058665_Chip-Seq_MCF-7_Human	1.95502337
16	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.94203750
17	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.91425444
18	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.88610585
19	XRN2_22483619_ChIP-Seq_HELA_Human	1.83332916
20	ATF3_27146783_Chip-Seq_COLON_Human	1.83260550
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.82498090
22	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.78381809
23	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.70189289
24	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.69059856
25	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.64590834
26	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.61876314
27	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.61876314
28	NCOR1_26117541_ChIP-Seq_K562_Human	1.60515713
29	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.59378102
30	AR_21909140_ChIP-Seq_LNCAP_Human	1.58619502
31	CLOCK_20551151_ChIP-Seq_293T_Human	1.57233429
32	LXR_22292898_ChIP-Seq_THP-1_Human	1.55801844
33	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.55533269
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.55495295
35	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.54728526
36	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.53605910
37	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.53211846
38	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.52420997
39	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.51769570
40	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.50106242
41	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.49826605
42	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.48794249
43	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.48274912
44	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.46611015
45	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.43554319
46	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.41980114
47	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.39356305
48	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.37325815
49	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.36288713
50	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.33581864
51	KDM5A_27292631_Chip-Seq_BREAST_Human	1.32919257
52	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.32045401
53	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.31651372
54	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.30795037
55	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.28358370
56	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.27967509
57	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.27413805
58	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.27098834
59	GATA6_25053715_ChIP-Seq_YYC3_Human	1.24589800
60	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.23582214
61	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.23291156
62	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.21821375
63	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.19691654
64	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.19627361
65	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.19582195
66	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.18875848
67	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.17939937
68	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.16832774
69	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.15837640
70	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.15819981
71	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.13258892
72	GABP_19822575_ChIP-Seq_HepG2_Human	1.12417149
73	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.12309749
74	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.11809066
75	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.11428821
76	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.10693542
77	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.07993447
78	P68_20966046_ChIP-Seq_HELA_Human	1.07664917
79	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.06062342
80	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.05884482
81	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.05500153
82	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.04622152
83	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.03578891
84	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.03536486
85	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.02598804
86	TTF2_22483619_ChIP-Seq_HELA_Human	1.02244631
87	SMC4_20622854_ChIP-Seq_HELA_Human	1.00669373
88	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.00636137
89	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.99344267
90	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.98550049
91	CHD1_26751641_Chip-Seq_LNCaP_Human	0.97032460
92	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.95369928
93	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.95264162
94	KDM2B_26808549_Chip-Seq_K562_Human	0.94542385
95	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.93568606
96	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	0.93442027
97	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.92997130
98	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.91255609
99	CREB1_26743006_Chip-Seq_LNCaP_Human	0.90943247
100	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.89786696

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	4.43092139
2	MP0010234_abnormal_vibrissa_follicle	4.20772146
3	MP0005451_abnormal_body_composition	3.36531925
4	MP0003705_abnormal_hypodermis_morpholog	2.77036343
5	MP0005076_abnormal_cell_differentiation	2.51208427
6	MP0004957_abnormal_blastocyst_morpholog	2.44687377
7	MP0004233_abnormal_muscle_weight	2.43232746
8	MP0002796_impaired_skin_barrier	2.37206896
9	MP0006054_spinal_hemorrhage	2.32396014
10	MP0000537_abnormal_urethra_morphology	2.27857891
11	MP0005501_abnormal_skin_physiology	2.27132113
12	MP0000467_abnormal_esophagus_morphology	2.18863238
13	MP0003890_abnormal_embryonic-extraembry	2.14883150
14	MP0005083_abnormal_biliary_tract	2.02440511
15	MP0002877_abnormal_melanocyte_morpholog	2.01577558
16	MP0000762_abnormal_tongue_morphology	1.99151083
17	MP0008932_abnormal_embryonic_tissue	1.94365045
18	MP0000678_abnormal_parathyroid_gland	1.87864234
19	MP0010678_abnormal_skin_adnexa	1.86648003
20	MP0010030_abnormal_orbit_morphology	1.83236462
21	MP0002098_abnormal_vibrissa_morphology	1.82025127
22	MP0010094_abnormal_chromosome_stability	1.81290777
23	MP0003453_abnormal_keratinocyte_physiol	1.81218417
24	MP0000383_abnormal_hair_follicle	1.80439461
25	MP0003950_abnormal_plasma_membrane	1.77182784
26	MP0003566_abnormal_cell_adhesion	1.73089930
27	MP0002060_abnormal_skin_morphology	1.69968249
28	MP0002234_abnormal_pharynx_morphology	1.68722550
29	MP0003693_abnormal_embryo_hatching	1.59111390
30	MP0003111_abnormal_nucleus_morphology	1.58862562
31	MP0003315_abnormal_perineum_morphology	1.55675838
32	MP0001348_abnormal_lacrimal_gland	1.53760890
33	MP0001216_abnormal_epidermal_layer	1.53326447
34	MP0003786_premature_aging	1.45024933
35	MP0003077_abnormal_cell_cycle	1.37790063
36	MP0004147_increased_porphyrin_level	1.34999509
37	MP0010771_integument_phenotype	1.33788637
38	MP0001730_embryonic_growth_arrest	1.31501273
39	MP0000566_synostosis	1.31296953
40	MP0003385_abnormal_body_wall	1.27447766
41	MP0004272_abnormal_basement_membrane	1.24256284
42	MP0004185_abnormal_adipocyte_glucose	1.23477832
43	MP0008058_abnormal_DNA_repair	1.23449384
44	MP0002086_abnormal_extraembryonic_tissu	1.22795927
45	MP0005623_abnormal_meninges_morphology	1.21045909
46	MP0002249_abnormal_larynx_morphology	1.20653330
47	MP0002080_prenatal_lethality	1.20382857
48	MP0003656_abnormal_erythrocyte_physiolo	1.20211859
49	MP0005380_embryogenesis_phenotype	1.20054373
50	MP0001672_abnormal_embryogenesis/_devel	1.20054373
51	MP0003984_embryonic_growth_retardation	1.18250099
52	MP0002084_abnormal_developmental_patter	1.14458391
53	MP0005275_abnormal_skin_tensile	1.14173914
54	MP0009053_abnormal_anal_canal	1.12160249
55	MP0008775_abnormal_heart_ventricle	1.11590234
56	MP0002089_abnormal_postnatal_growth/wei	1.11242308
57	MP0003755_abnormal_palate_morphology	1.10814077
58	MP0000462_abnormal_digestive_system	1.09506639
59	MP0000350_abnormal_cell_proliferation	1.08518348
60	MP0004782_abnormal_surfactant_physiolog	1.08328836
61	MP0002088_abnormal_embryonic_growth/wei	1.07540427
62	MP0008995_early_reproductive_senescence	1.06372329
63	MP0005394_taste/olfaction_phenotype	1.06174797
64	MP0005499_abnormal_olfactory_system	1.06174797
65	MP0008438_abnormal_cutaneous_collagen	1.05247181
66	MP0009931_abnormal_skin_appearance	1.04386624
67	MP0001697_abnormal_embryo_size	1.03222970
68	MP0003935_abnormal_craniofacial_develop	1.02754661
69	MP0008875_abnormal_xenobiotic_pharmacok	1.02346140
70	MP0008789_abnormal_olfactory_epithelium	0.97509612
71	MP0002085_abnormal_embryonic_tissue	0.95648430
72	MP0001849_ear_inflammation	0.94434204
73	MP0002111_abnormal_tail_morphology	0.94410701
74	MP0005197_abnormal_uvea_morphology	0.91923640
75	MP0000377_abnormal_hair_follicle	0.91840182
76	MP0000049_abnormal_middle_ear	0.91329991
77	MP0004197_abnormal_fetal_growth/weight/	0.90696328
78	MP0001340_abnormal_eyelid_morphology	0.90589458
79	MP0005171_absent_coat_pigmentation	0.89226871
80	MP0004858_abnormal_nervous_system	0.86545133
81	MP0003329_amyloid_beta_deposits	0.85711433
82	MP0005666_abnormal_adipose_tissue	0.83367240
83	MP0008770_decreased_survivor_rate	0.83187827
84	MP0004264_abnormal_extraembryonic_tissu	0.81050956
85	MP0009250_abnormal_appendicular_skeleto	0.80884233
86	MP0002697_abnormal_eye_size	0.80774445
87	MP0000647_abnormal_sebaceous_gland	0.80683023
88	MP0001661_extended_life_span	0.80286188
89	MP0004019_abnormal_vitamin_homeostasis	0.79938724
90	MP0000358_abnormal_cell_content/	0.78580854
91	MP0005330_cardiomyopathy	0.76223355
92	MP0003718_maternal_effect	0.74073677
93	MP0001915_intracranial_hemorrhage	0.73232386
94	MP0000003_abnormal_adipose_tissue	0.71625479
95	MP0005621_abnormal_cell_physiology	0.71331774
96	MP0003879_abnormal_hair_cell	0.71054767
97	MP0003937_abnormal_limbs/digits/tail_de	0.70729212
98	MP0005409_darkened_coat_color	0.70528331
99	MP0000367_abnormal_coat/_hair	0.67597583
100	MP0003115_abnormal_respiratory_system	0.66326039

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ankyloglossia (HP:0010296)	6.31361518
2	Abnormality of oral frenula (HP:0000190)	4.89831635
3	Milia (HP:0001056)	4.44490529
4	Onycholysis (HP:0001806)	3.90333064
5	Fragile nails (HP:0001808)	3.65169979
6	Upper limb amyotrophy (HP:0009129)	3.50815722
7	Distal upper limb amyotrophy (HP:0007149)	3.50815722
8	Atrophic scars (HP:0001075)	3.48116936
9	Truncus arteriosus (HP:0001660)	3.31987638
10	Nail dystrophy (HP:0008404)	3.30242935
11	Plantar hyperkeratosis (HP:0007556)	3.25538318
12	Reticulocytosis (HP:0001923)	3.23170915
13	Fragile skin (HP:0001030)	3.22560558
14	Pili torti (HP:0003777)	3.18878799
15	Cholecystitis (HP:0001082)	3.17999600
16	Abnormal gallbladder physiology (HP:0012438)	3.17999600
17	Pterygium (HP:0001059)	3.12242857
18	Thick nail (HP:0001805)	3.11122425
19	Abnormality of glycolysis (HP:0004366)	3.10281651
20	Hand muscle atrophy (HP:0009130)	3.02359204
21	Hypotrichosis (HP:0001006)	2.95253536
22	Upper limb muscle weakness (HP:0003484)	2.91739268
23	Septate vagina (HP:0001153)	2.86776489
24	Right ventricular cardiomyopathy (HP:0011663)	2.79101947
25	Ureteral duplication (HP:0000073)	2.76513462
26	Broad face (HP:0000283)	2.75623153
27	Short nail (HP:0001799)	2.65997601
28	Abnormal hair laboratory examination (HP:0003328)	2.63684378
29	Coronal craniosynostosis (HP:0004440)	2.55406857
30	Alopecia of scalp (HP:0002293)	2.55036718
31	Hyperacusis (HP:0010780)	2.54767416
32	Aplasia cutis congenita (HP:0001057)	2.50661910
33	Ulnar bowing (HP:0003031)	2.49711620
34	Ridged nail (HP:0001807)	2.49213145
35	Deviation of the thumb (HP:0009603)	2.45281336
36	Abnormality of reticulocytes (HP:0004312)	2.42222435
37	Squamous cell carcinoma (HP:0002860)	2.36171545
38	Distal lower limb amyotrophy (HP:0008944)	2.32469476
39	Proximal placement of thumb (HP:0009623)	2.31013621
40	Increased serum pyruvate (HP:0003542)	2.29329177
41	Hypoparathyroidism (HP:0000829)	2.28180046
42	Palmar hyperkeratosis (HP:0010765)	2.22522931
43	Palmoplantar hyperkeratosis (HP:0000972)	2.21174492
44	Abnormality of nail color (HP:0100643)	2.20547521
45	Premature rupture of membranes (HP:0001788)	2.20544450
46	Orthostatic hypotension (HP:0001278)	2.20526821
47	Increased connective tissue (HP:0009025)	2.20319300
48	Abnormal sex determination (HP:0012244)	2.18575273
49	Sex reversal (HP:0012245)	2.18575273
50	Patellar dislocation (HP:0002999)	2.18508703
51	Seborrheic dermatitis (HP:0001051)	2.17893827
52	Breast hypoplasia (HP:0003187)	2.16464867
53	Selective tooth agenesis (HP:0001592)	2.16224571
54	Poikiloderma (HP:0001029)	2.12054959
55	Sparse eyelashes (HP:0000653)	2.11360632
56	Hyperthyroidism (HP:0000836)	2.08007694
57	Mildly elevated creatine phosphokinase (HP:0008180)	2.07627769
58	Abnormality of the tricuspid valve (HP:0001702)	2.05074642
59	Focal segmental glomerulosclerosis (HP:0000097)	2.04745022
60	Popliteal pterygium (HP:0009756)	2.03794451
61	Duplicated collecting system (HP:0000081)	2.03697958
62	Abnormality of the umbilical cord (HP:0010881)	2.02591377
63	Long foot (HP:0001833)	2.00985015
64	Abnormalities of placenta or umbilical cord (HP:0001194)	2.00828537
65	Insomnia (HP:0100785)	1.99285827
66	Cholelithiasis (HP:0001081)	1.95901231
67	Hypoplasia of dental enamel (HP:0006297)	1.93564413
68	Acanthosis nigricans (HP:0000956)	1.92800526
69	Advanced eruption of teeth (HP:0006288)	1.90522406
70	Achilles tendon contracture (HP:0001771)	1.88188211
71	Self-mutilation (HP:0000742)	1.85895507
72	Autoamputation (HP:0001218)	1.85550187
73	Dysautonomia (HP:0002459)	1.84826465
74	Entropion (HP:0000621)	1.83263147
75	Blepharitis (HP:0000498)	1.81437445
76	Bowel incontinence (HP:0002607)	1.79741072
77	Abnormality of the nasal septum (HP:0000419)	1.78697775
78	Urethral obstruction (HP:0000796)	1.77823537
79	Abnormality of the distal phalanges of the toes (HP:0010182)	1.77778261
80	Oligodontia (HP:0000677)	1.77745264
81	Elbow flexion contracture (HP:0002987)	1.75855435
82	Flat acetabular roof (HP:0003180)	1.75447451
83	Abnormal large intestine physiology (HP:0012700)	1.74682034
84	Abnormality of the preputium (HP:0100587)	1.73910421
85	Progressive muscle weakness (HP:0003323)	1.71644790
86	Increased nuchal translucency (HP:0010880)	1.71609928
87	Chromsome breakage (HP:0040012)	1.71234518
88	Impaired pain sensation (HP:0007328)	1.69514132
89	Abnormality of pain sensation (HP:0010832)	1.69514132
90	Nasolacrimal duct obstruction (HP:0000579)	1.69369092
91	Trismus (HP:0000211)	1.69254579
92	Abnormal blistering of the skin (HP:0008066)	1.69158519
93	Small intestinal stenosis (HP:0012848)	1.69096125
94	Duodenal stenosis (HP:0100867)	1.69096125
95	Glossoptosis (HP:0000162)	1.67904233
96	Abnormal gallbladder morphology (HP:0012437)	1.65513910
97	Amniotic constriction ring (HP:0009775)	1.65416057
98	Abnormality of placental membranes (HP:0011409)	1.65416057
99	Vaginal fistula (HP:0004320)	1.65018677
100	Termporal pattern (HP:0011008)	1.65001841

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	5.65830454
2	EPHA2	4.48712842
3	IRAK3	3.80685649
4	SIK1	2.97387175
5	STK10	2.91657802
6	MET	2.87511363
7	NTRK1	2.42251636
8	EIF2AK1	2.35776719
9	LMTK2	2.23985817
10	NME2	2.07571882
11	ICK	1.99350539
12	PDK2	1.97525213
13	PBK	1.91631002
14	IRAK2	1.87158813
15	LRRK2	1.86377905
16	LATS2	1.79754569
17	EEF2K	1.78574402
18	MAP3K8	1.73976967
19	ERBB4	1.71008854
20	PIM2	1.67481274
21	MAP3K2	1.62878029
22	ERN1	1.62833156
23	ARAF	1.58762750
24	WNK4	1.56579204
25	PKN2	1.50404361
26	NEK1	1.50220323
27	PAK4	1.49849854
28	RPS6KB2	1.44416773
29	RAF1	1.38791255
30	TRIB3	1.28033175
31	MATK	1.25652204
32	MAP3K9	1.24662720
33	MUSK	1.19577456
34	FLT3	1.17493427
35	SIK3	1.16560945
36	EPHB1	1.11089272
37	SMG1	1.06136541
38	MAPKAPK5	1.03852240
39	SRPK1	1.03075585
40	TTK	0.97602696
41	KSR2	0.95924955
42	BRSK1	0.94740744
43	NME1	0.94560107
44	CDK8	0.88855029
45	MTOR	0.86327807
46	MAPK11	0.82204048
47	LATS1	0.81349521
48	EPHB2	0.80820827
49	PTK2	0.80570976
50	EIF2AK3	0.76740226
51	CDK12	0.76392060
52	PRKG2	0.74552947
53	BMX	0.74268441
54	TTN	0.68699502
55	WEE1	0.68075070
56	MAP3K12	0.67715460
57	PRKD3	0.63117887
58	TESK1	0.62524405
59	ILK	0.61726202
60	AURKB	0.61023452
61	NEK2	0.59612941
62	CHEK1	0.59495293
63	SCYL2	0.57414236
64	PRKCI	0.53008435
65	KSR1	0.52767071
66	MAP2K1	0.52740158
67	RPS6KA4	0.51596822
68	ROCK2	0.50622548
69	PDGFRA	0.48722288
70	PRPF4B	0.47939139
71	STK38	0.46881889
72	AURKA	0.46852126
73	YES1	0.44663949
74	CAMK2B	0.43862201
75	DDR2	0.42990221
76	CDK7	0.42670682
77	IRAK4	0.42125483
78	CLK1	0.41949639
79	CAMK2G	0.41516151
80	TRPM7	0.40074104
81	PAK2	0.39356286
82	MAP2K2	0.38318476
83	CHEK2	0.38219541
84	TSSK6	0.37683801
85	CDK1	0.37262686
86	BRD4	0.36092704
87	STK39	0.35421385
88	BRAF	0.35249687
89	CDC7	0.35091346
90	DYRK3	0.32487667
91	TRIM28	0.31980368
92	CDK2	0.31417123
93	MAP3K7	0.31292108
94	AKT2	0.31179723
95	TYRO3	0.28742562
96	ROCK1	0.28406128
97	MAP3K13	0.26097170
98	PTK6	0.25342895
99	CAMK1D	0.23761745
100	PLK1	0.23738984

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur metabolism_Homo sapiens_hsa00920	3.42388079
2	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.21134283
3	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.91205633
4	Steroid biosynthesis_Homo sapiens_hsa00100	2.70028842
5	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.45948779
6	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.38782316
7	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.33478033
8	Folate biosynthesis_Homo sapiens_hsa00790	2.27338923
9	Central carbon metabolism in cancer_Homo sapiens_hsa05230	2.12034266
10	Pentose phosphate pathway_Homo sapiens_hsa00030	2.11724101
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.98175919
12	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.80855696
13	Galactose metabolism_Homo sapiens_hsa00052	1.80655021
14	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.79834041
15	Carbon metabolism_Homo sapiens_hsa01200	1.79157219
16	One carbon pool by folate_Homo sapiens_hsa00670	1.72655020
17	DNA replication_Homo sapiens_hsa03030	1.70591607
18	RNA transport_Homo sapiens_hsa03013	1.63164817
19	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.61004652
20	Pyruvate metabolism_Homo sapiens_hsa00620	1.60562203
21	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.53896392
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.51088087
23	Base excision repair_Homo sapiens_hsa03410	1.45476578
24	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.39845667
25	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.37984606
26	Thyroid cancer_Homo sapiens_hsa05216	1.35644700
27	mRNA surveillance pathway_Homo sapiens_hsa03015	1.34349851
28	Sulfur relay system_Homo sapiens_hsa04122	1.33813932
29	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.24912037
30	Fatty acid metabolism_Homo sapiens_hsa01212	1.19559883
31	Cell cycle_Homo sapiens_hsa04110	1.19194289
32	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.15406845
33	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.14890252
34	Spliceosome_Homo sapiens_hsa03040	1.14079175
35	Mismatch repair_Homo sapiens_hsa03430	1.11212704
36	Arginine biosynthesis_Homo sapiens_hsa00220	1.09465478
37	Small cell lung cancer_Homo sapiens_hsa05222	1.08857219
38	ECM-receptor interaction_Homo sapiens_hsa04512	1.08070427
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.06800642
40	Glutathione metabolism_Homo sapiens_hsa00480	1.06393903
41	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.05577960
42	Phenylalanine metabolism_Homo sapiens_hsa00360	1.00956044
43	Non-homologous end-joining_Homo sapiens_hsa03450	0.95281567
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.94854481
45	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.91485368
46	Homologous recombination_Homo sapiens_hsa03440	0.88997821
47	MicroRNAs in cancer_Homo sapiens_hsa05206	0.87150588
48	Basal transcription factors_Homo sapiens_hsa03022	0.85957114
49	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.83343302
50	Bladder cancer_Homo sapiens_hsa05219	0.81188439
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.79861599
52	Fanconi anemia pathway_Homo sapiens_hsa03460	0.78905838
53	Lysine degradation_Homo sapiens_hsa00310	0.77445649
54	ABC transporters_Homo sapiens_hsa02010	0.76619440
55	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76543026
56	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.73278181
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73168212
58	Adherens junction_Homo sapiens_hsa04520	0.72980534
59	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.72708834
60	Vibrio cholerae infection_Homo sapiens_hsa05110	0.70885654
61	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.66609458
62	Hippo signaling pathway_Homo sapiens_hsa04390	0.64862670
63	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.64478404
64	ErbB signaling pathway_Homo sapiens_hsa04012	0.63894136
65	Insulin signaling pathway_Homo sapiens_hsa04910	0.59583641
66	Prion diseases_Homo sapiens_hsa05020	0.56999892
67	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.56615297
68	Proteoglycans in cancer_Homo sapiens_hsa05205	0.56579763
69	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.55771163
70	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53231992
71	Bile secretion_Homo sapiens_hsa04976	0.51793928
72	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.51445321
73	Other glycan degradation_Homo sapiens_hsa00511	0.48858410
74	Focal adhesion_Homo sapiens_hsa04510	0.47570008
75	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.46962962
76	Proteasome_Homo sapiens_hsa03050	0.44998688
77	Metabolic pathways_Homo sapiens_hsa01100	0.44080404
78	Tyrosine metabolism_Homo sapiens_hsa00350	0.43895793
79	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.43393103
80	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.43288491
81	Purine metabolism_Homo sapiens_hsa00230	0.42789230
82	Ribosome_Homo sapiens_hsa03010	0.42177521
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.40644442
84	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.40234110
85	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.39909040
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.39600704
87	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.39448914
88	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.38620786
89	mTOR signaling pathway_Homo sapiens_hsa04150	0.37306134
90	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.35905303
91	Retinol metabolism_Homo sapiens_hsa00830	0.35779683
92	Fatty acid elongation_Homo sapiens_hsa00062	0.35625430
93	Basal cell carcinoma_Homo sapiens_hsa05217	0.35257416
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.35186589
95	RNA polymerase_Homo sapiens_hsa03020	0.34908084
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.34658529
97	RNA degradation_Homo sapiens_hsa03018	0.34636829
98	Propanoate metabolism_Homo sapiens_hsa00640	0.34255045
99	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.31292670
100	Selenocompound metabolism_Homo sapiens_hsa00450	0.29314653

IGFL1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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