IGFL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)4.71703908
2response to pheromone (GO:0019236)4.44947636
3indole-containing compound catabolic process (GO:0042436)4.42555465
4indolalkylamine catabolic process (GO:0046218)4.42555465
5tryptophan catabolic process (GO:0006569)4.42555465
6kynurenine metabolic process (GO:0070189)4.38502203
7regulation of sister chromatid cohesion (GO:0007063)4.28085891
8heart field specification (GO:0003128)4.09973281
9secondary heart field specification (GO:0003139)4.09973281
10tryptophan metabolic process (GO:0006568)4.01489920
11DNA double-strand break processing (GO:0000729)4.00585809
12indolalkylamine metabolic process (GO:0006586)3.99988016
13piRNA metabolic process (GO:0034587)3.91457685
14sphingoid metabolic process (GO:0046519)3.86321713
15behavioral response to nicotine (GO:0035095)3.84900091
16positive regulation of meiotic cell cycle (GO:0051446)3.81020097
17protein K11-linked deubiquitination (GO:0035871)3.77377039
18regulation of hexokinase activity (GO:1903299)3.77315167
19regulation of glucokinase activity (GO:0033131)3.77315167
20respiratory chain complex IV assembly (GO:0008535)3.69616124
21sphingosine metabolic process (GO:0006670)3.67595443
22cytochrome complex assembly (GO:0017004)3.66147946
23L-fucose catabolic process (GO:0042355)3.50538435
24fucose catabolic process (GO:0019317)3.50538435
25L-fucose metabolic process (GO:0042354)3.50538435
26DNA deamination (GO:0045006)3.43623270
27detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.41767556
28regulation of meiosis I (GO:0060631)3.40341848
29dorsal/ventral axis specification (GO:0009950)3.39568104
30cellular ketone body metabolic process (GO:0046950)3.37113572
31keratinocyte development (GO:0003334)3.34142689
32diol metabolic process (GO:0034311)3.33635762
33behavioral response to ethanol (GO:0048149)3.30178433
34positive regulation of meiosis (GO:0045836)3.25047587
35detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.23311026
36photoreceptor cell maintenance (GO:0045494)3.20471869
37RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.18917310
38detection of light stimulus involved in visual perception (GO:0050908)3.18840417
39detection of light stimulus involved in sensory perception (GO:0050962)3.18840417
40ketone body metabolic process (GO:1902224)3.15253795
41replication fork processing (GO:0031297)3.14645970
42centriole replication (GO:0007099)3.11305835
43glial cell proliferation (GO:0014009)3.03552203
44negative regulation of cytosolic calcium ion concentration (GO:0051481)3.00299859
45detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.98579949
46indole-containing compound metabolic process (GO:0042430)2.96669940
47recombinational repair (GO:0000725)2.96479231
48synapsis (GO:0007129)2.96062432
49response to methylmercury (GO:0051597)2.94960742
50double-strand break repair via homologous recombination (GO:0000724)2.93317935
51DNA methylation involved in gamete generation (GO:0043046)2.93234841
52neural tube formation (GO:0001841)2.91078056
53cellular biogenic amine catabolic process (GO:0042402)2.87822010
54amine catabolic process (GO:0009310)2.87822010
55specification of organ identity (GO:0010092)2.83304500
56negative regulation of transcription regulatory region DNA binding (GO:2000678)2.83173174
57hair cycle (GO:0042633)2.82889215
58molting cycle (GO:0042303)2.82889215
59establishment of protein localization to Golgi (GO:0072600)2.80151042
60reciprocal DNA recombination (GO:0035825)2.78677460
61reciprocal meiotic recombination (GO:0007131)2.78677460
62L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.76356995
63response to hydroperoxide (GO:0033194)2.74488927
64GMP metabolic process (GO:0046037)2.73170272
65negative regulation of epidermal cell differentiation (GO:0045605)2.72282280
66regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.71171662
67positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.71171662
68ectoderm development (GO:0007398)2.70910111
69axoneme assembly (GO:0035082)2.68084398
70auditory receptor cell stereocilium organization (GO:0060088)2.66841755
71DNA integration (GO:0015074)2.65603659
72protein K6-linked ubiquitination (GO:0085020)2.65447889
73phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.64948612
74regulation of cilium movement (GO:0003352)2.64209488
75protein targeting to Golgi (GO:0000042)2.63810316
76somatic hypermutation of immunoglobulin genes (GO:0016446)2.63243663
77somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63243663
78protein localization to cilium (GO:0061512)2.62510501
79phosphatidylinositol acyl-chain remodeling (GO:0036149)2.62087664
80regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.59845910
81cellular response to sterol (GO:0036315)2.59005410
82preassembly of GPI anchor in ER membrane (GO:0016254)2.58559492
83dopamine transport (GO:0015872)2.58225798
84pyrimidine dimer repair (GO:0006290)2.58059095
85natural killer cell activation involved in immune response (GO:0002323)2.56317024
86tachykinin receptor signaling pathway (GO:0007217)2.56219044
87cornea development in camera-type eye (GO:0061303)2.55406589
88male meiosis (GO:0007140)2.54672334
89regulation of cell proliferation involved in kidney development (GO:1901722)2.52584471
90adaptation of signaling pathway (GO:0023058)2.52125807
91rRNA catabolic process (GO:0016075)2.51380445
92pseudouridine synthesis (GO:0001522)2.50396588
93adenosine metabolic process (GO:0046085)2.49525971
94negative regulation of T cell differentiation in thymus (GO:0033085)2.49143412
95establishment of skin barrier (GO:0061436)2.47999478
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47477890
97cilium morphogenesis (GO:0060271)2.44971861
98positive regulation of catenin import into nucleus (GO:0035413)2.44497613
99nucleotide transmembrane transport (GO:1901679)2.42392149
100inner ear receptor stereocilium organization (GO:0060122)2.41821838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.45517271
2IGF1R_20145208_ChIP-Seq_DFB_Human3.27521899
3ZNF274_21170338_ChIP-Seq_K562_Hela3.27210704
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.13025016
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.77394943
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46923830
7VDR_22108803_ChIP-Seq_LS180_Human2.37685406
8EWS_26573619_Chip-Seq_HEK293_Human2.36024667
9GBX2_23144817_ChIP-Seq_PC3_Human2.32846317
10FUS_26573619_Chip-Seq_HEK293_Human2.31126748
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21866835
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.21305602
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18760233
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.16103622
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.14623502
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08118239
17P300_19829295_ChIP-Seq_ESCs_Human2.04000302
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01858687
19TAF15_26573619_Chip-Seq_HEK293_Human1.97563676
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96385669
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92409500
22ER_23166858_ChIP-Seq_MCF-7_Human1.90717063
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85107124
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.80272647
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.78160227
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71822955
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69245068
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68920326
29* CBP_20019798_ChIP-Seq_JUKART_Human1.65303514
30* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65303514
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.62305124
32BCAT_22108803_ChIP-Seq_LS180_Human1.61818445
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61091428
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59331285
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57353334
36ELK1_19687146_ChIP-ChIP_HELA_Human1.57188958
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.50329217
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49943004
39TCF4_22108803_ChIP-Seq_LS180_Human1.49707596
40SMAD4_21799915_ChIP-Seq_A2780_Human1.49213532
41TCF4_23295773_ChIP-Seq_U87_Human1.48691791
42MYC_18940864_ChIP-ChIP_HL60_Human1.47899936
43STAT3_23295773_ChIP-Seq_U87_Human1.47808435
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.47122204
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45723883
46IRF1_19129219_ChIP-ChIP_H3396_Human1.45595005
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.37593688
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36811489
49VDR_23849224_ChIP-Seq_CD4+_Human1.36327664
50AR_25329375_ChIP-Seq_VCAP_Human1.35902873
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35176428
52* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32716147
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31622430
54NANOG_19829295_ChIP-Seq_ESCs_Human1.31066022
55SOX2_19829295_ChIP-Seq_ESCs_Human1.31066022
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30906969
57TP53_22573176_ChIP-Seq_HFKS_Human1.30721953
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28630413
59FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27843363
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26040465
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.24419245
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.23681333
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23496735
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.23496735
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23431720
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23198506
67CDX2_22108803_ChIP-Seq_LS180_Human1.23018142
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22470986
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22447677
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22225864
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20087911
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19824299
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18951789
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16536756
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16536756
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.15819570
77AR_20517297_ChIP-Seq_VCAP_Human1.14872949
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14319100
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.14213216
80NCOR_22424771_ChIP-Seq_293T_Human1.13887746
81GATA1_22025678_ChIP-Seq_K562_Human1.11825621
82E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09021531
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07544899
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06326056
85HOXB7_26014856_ChIP-Seq_BT474_Human1.05928916
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05827474
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.05465998
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04301027
89FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04271165
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04150354
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03846696
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02645771
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.01226017
94RUNX2_22187159_ChIP-Seq_PCA_Human1.00365391
95E2F1_18555785_Chip-Seq_ESCs_Mouse0.97468572
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96831413
97SRF_21415370_ChIP-Seq_HL-1_Mouse0.96580030
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.94913561
99SALL4_22934838_ChIP-ChIP_CD34+_Human0.94639086
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94553924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity6.72012574
2MP0010234_abnormal_vibrissa_follicle3.91878372
3MP0002254_reproductive_system_inflammat3.58182497
4MP0008877_abnormal_DNA_methylation3.09253798
5MP0000427_abnormal_hair_cycle2.97715420
6MP0010678_abnormal_skin_adnexa2.61033286
7MP0000383_abnormal_hair_follicle2.43264247
8MP0008057_abnormal_DNA_replication2.26480005
9MP0000372_irregular_coat_pigmentation2.26280952
10MP0006072_abnormal_retinal_apoptosis2.19866790
11MP0002098_abnormal_vibrissa_morphology2.19157641
12MP0005551_abnormal_eye_electrophysiolog2.15243771
13MP0008058_abnormal_DNA_repair2.07081091
14MP0008875_abnormal_xenobiotic_pharmacok2.04475047
15MP0000647_abnormal_sebaceous_gland1.92047101
16MP0005253_abnormal_eye_physiology1.88092477
17MP0003195_calcinosis1.83908040
18MP0002102_abnormal_ear_morphology1.83781835
19MP0002735_abnormal_chemical_nociception1.82118816
20MP0005367_renal/urinary_system_phenotyp1.79912133
21MP0000516_abnormal_urinary_system1.79912133
22MP0000569_abnormal_digit_pigmentation1.76022383
23MP0002796_impaired_skin_barrier1.74237866
24MP0005646_abnormal_pituitary_gland1.70435689
25MP0004147_increased_porphyrin_level1.69319890
26MP0001984_abnormal_olfaction1.68235567
27MP0005075_abnormal_melanosome_morpholog1.66436161
28MP0004043_abnormal_pH_regulation1.59364513
29MP0005645_abnormal_hypothalamus_physiol1.55332510
30MP0008872_abnormal_physiological_respon1.54620985
31MP0009780_abnormal_chondrocyte_physiolo1.49998624
32MP0002234_abnormal_pharynx_morphology1.47428956
33MP0002837_dystrophic_cardiac_calcinosis1.47101958
34MP0005174_abnormal_tail_pigmentation1.45496167
35MP0002095_abnormal_skin_pigmentation1.45084993
36MP0002876_abnormal_thyroid_physiology1.41698484
37MP0001968_abnormal_touch/_nociception1.37308223
38MP0010094_abnormal_chromosome_stability1.33158930
39MP0002163_abnormal_gland_morphology1.30976540
40MP0002938_white_spotting1.29742826
41MP0003718_maternal_effect1.29353517
42MP0000579_abnormal_nail_morphology1.28156912
43MP0005501_abnormal_skin_physiology1.28018835
44MP0002736_abnormal_nociception_after1.19152903
45MP0000377_abnormal_hair_follicle1.19037042
46MP0005275_abnormal_skin_tensile1.17042812
47MP0000015_abnormal_ear_pigmentation1.16783936
48MP0010771_integument_phenotype1.14980997
49MP0008995_early_reproductive_senescence1.14189061
50MP0003786_premature_aging1.12980728
51MP0003646_muscle_fatigue1.12378875
52MP0009697_abnormal_copulation1.12305786
53MP0009046_muscle_twitch1.11747067
54MP0001764_abnormal_homeostasis1.11674558
55MP0003787_abnormal_imprinting1.09932776
56MP0003011_delayed_dark_adaptation1.07814124
57MP0004742_abnormal_vestibular_system1.06148795
58MP0001929_abnormal_gametogenesis1.04924537
59MP0003252_abnormal_bile_duct1.00466624
60MP0005391_vision/eye_phenotype0.97795644
61MP0001501_abnormal_sleep_pattern0.97763633
62MP0003698_abnormal_male_reproductive0.97633649
63MP0003937_abnormal_limbs/digits/tail_de0.96435996
64MP0002638_abnormal_pupillary_reflex0.92862627
65MP0000631_abnormal_neuroendocrine_gland0.92011718
66MP0000653_abnormal_sex_gland0.91781640
67MP0003950_abnormal_plasma_membrane0.91549158
68MP0002210_abnormal_sex_determination0.90890592
69MP0006054_spinal_hemorrhage0.88900094
70MP0008775_abnormal_heart_ventricle0.88435884
71MP0001485_abnormal_pinna_reflex0.88146387
72MP0005410_abnormal_fertilization0.86690488
73MP0001486_abnormal_startle_reflex0.85887023
74MP0005379_endocrine/exocrine_gland_phen0.84413907
75MP0005408_hypopigmentation0.84374344
76MP0004924_abnormal_behavior0.82273757
77MP0005386_behavior/neurological_phenoty0.82273757
78MP0009745_abnormal_behavioral_response0.81552121
79MP0002733_abnormal_thermal_nociception0.80058126
80MP0001216_abnormal_epidermal_layer0.79739834
81MP0003656_abnormal_erythrocyte_physiolo0.78797855
82MP0002160_abnormal_reproductive_system0.78695331
83MP0003045_fibrosis0.78457666
84MP0010386_abnormal_urinary_bladder0.77848101
85MP0003693_abnormal_embryo_hatching0.76842073
86MP0003943_abnormal_hepatobiliary_system0.75512840
87MP0005389_reproductive_system_phenotype0.74256635
88MP0001145_abnormal_male_reproductive0.73887154
89MP0004885_abnormal_endolymph0.72075920
90MP0004215_abnormal_myocardial_fiber0.71956000
91MP0003136_yellow_coat_color0.71808538
92MP0002734_abnormal_mechanical_nocicepti0.71505526
93MP0004782_abnormal_surfactant_physiolog0.71384241
94MP0005647_abnormal_sex_gland0.70495089
95MP0001970_abnormal_pain_threshold0.70314322
96MP0001119_abnormal_female_reproductive0.70044566
97MP0004381_abnormal_hair_follicle0.69270326
98MP0001324_abnormal_eye_pigmentation0.67167427
99MP0003890_abnormal_embryonic-extraembry0.66932184
100MP0002928_abnormal_bile_duct0.66541037

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.51136231
2Abnormality of midbrain morphology (HP:0002418)3.34938148
3Molar tooth sign on MRI (HP:0002419)3.34938148
4Pili torti (HP:0003777)3.28758915
5Palmoplantar hyperkeratosis (HP:0000972)3.26573433
6Palmar hyperkeratosis (HP:0010765)3.19954788
7Congenital stationary night blindness (HP:0007642)3.17838906
8True hermaphroditism (HP:0010459)3.14445146
9Nephronophthisis (HP:0000090)3.06719019
10Pancreatic fibrosis (HP:0100732)2.95674152
11Abnormality of the renal medulla (HP:0100957)2.75630677
12Medial flaring of the eyebrow (HP:0010747)2.72287313
13Gaze-evoked nystagmus (HP:0000640)2.70041846
14Attenuation of retinal blood vessels (HP:0007843)2.64186993
15Plantar hyperkeratosis (HP:0007556)2.62673313
16Hypotrichosis (HP:0001006)2.49877709
17Erythroderma (HP:0001019)2.46533765
18Chronic hepatic failure (HP:0100626)2.43026815
19Fair hair (HP:0002286)2.40472465
20Sparse scalp hair (HP:0002209)2.39299800
21Cerebellar dysplasia (HP:0007033)2.35042025
22Anhidrosis (HP:0000970)2.35040796
23Thyroiditis (HP:0100646)2.34009436
24Sparse eyelashes (HP:0000653)2.33464590
25Intestinal atresia (HP:0011100)2.32407586
26Abnormality of the pons (HP:0007361)2.30583785
27Abnormality of the renal cortex (HP:0011035)2.30248367
28Congenital, generalized hypertrichosis (HP:0004540)2.28104430
29Aplasia/Hypoplasia of the tongue (HP:0010295)2.27957624
30Pendular nystagmus (HP:0012043)2.25607915
31Furrowed tongue (HP:0000221)2.25293203
32Hyperventilation (HP:0002883)2.24919857
33Increased CSF lactate (HP:0002490)2.22788495
34Type II lissencephaly (HP:0007260)2.21053140
35Tubulointerstitial nephritis (HP:0001970)2.18760753
36Decreased central vision (HP:0007663)2.17001160
37Sclerocornea (HP:0000647)2.16928234
38Tubular atrophy (HP:0000092)2.16293863
39Cystic liver disease (HP:0006706)2.13343269
40Tubulointerstitial abnormality (HP:0001969)2.11655786
41Chromsome breakage (HP:0040012)2.11573433
42Hypoalbuminemia (HP:0003073)2.10247077
43Abnormal albumin level (HP:0012116)2.10247077
44Hypoproteinemia (HP:0003075)2.09939766
45Horizontal nystagmus (HP:0000666)2.09396360
46Abnormal rod and cone electroretinograms (HP:0008323)2.08918533
47Abnormal hair laboratory examination (HP:0003328)2.08676347
48Oligodontia (HP:0000677)2.05761888
49Hypoplasia of the pons (HP:0012110)2.05214987
50Long clavicles (HP:0000890)2.02388636
51Hypoplasia of the uterus (HP:0000013)2.00388997
52Abnormality of the preputium (HP:0100587)1.99410992
53Hyperglycinemia (HP:0002154)1.98969261
54Neoplasm of the adrenal cortex (HP:0100641)1.97768250
55Congenital ichthyosiform erythroderma (HP:0007431)1.97240751
56Hepatocellular necrosis (HP:0001404)1.96875608
57Abnormality of nail color (HP:0100643)1.96767143
58Congenital primary aphakia (HP:0007707)1.96531358
59Absent speech (HP:0001344)1.96029435
60Chorioretinal atrophy (HP:0000533)1.95440186
61Large for gestational age (HP:0001520)1.95414788
62Gait imbalance (HP:0002141)1.92815451
63Glioma (HP:0009733)1.92221103
64Hypothermia (HP:0002045)1.91926903
65Postaxial foot polydactyly (HP:0001830)1.90282050
66Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90180265
67Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.89395000
68Hypoplastic labia majora (HP:0000059)1.86103408
69Ketoacidosis (HP:0001993)1.85836655
70Acute encephalopathy (HP:0006846)1.85661186
71Abnormality of hair growth rate (HP:0011363)1.84889491
72Slow-growing hair (HP:0002217)1.84889491
73Aplasia/hypoplasia of the uterus (HP:0008684)1.84466476
74Mitochondrial inheritance (HP:0001427)1.84418862
75Bony spicule pigmentary retinopathy (HP:0007737)1.82767779
76Disproportionate short-trunk short stature (HP:0003521)1.82243576
77Aplasia/Hypoplasia of the uvula (HP:0010293)1.81953125
78Keratoconus (HP:0000563)1.81577379
79Increased corneal curvature (HP:0100692)1.81577379
80Abnormality of macular pigmentation (HP:0008002)1.80906330
81Abnormal drinking behavior (HP:0030082)1.80587981
82Polydipsia (HP:0001959)1.80587981
83Volvulus (HP:0002580)1.80123021
84Generalized hypopigmentation of hair (HP:0011358)1.79439558
85Hamartoma of the eye (HP:0010568)1.78867318
86Abolished electroretinogram (ERG) (HP:0000550)1.78432886
87Hepatic necrosis (HP:0002605)1.77818165
88Nephrogenic diabetes insipidus (HP:0009806)1.77101344
89Increased serum lactate (HP:0002151)1.77068521
90Oculomotor apraxia (HP:0000657)1.76466883
91Tubulointerstitial fibrosis (HP:0005576)1.76430323
92Clubbing of toes (HP:0100760)1.75570732
93Amelogenesis imperfecta (HP:0000705)1.75068164
94Parakeratosis (HP:0001036)1.74587828
95Hyperglycinuria (HP:0003108)1.73809659
96Renal cortical cysts (HP:0000803)1.73598360
97Methylmalonic acidemia (HP:0002912)1.72866657
98Abnormality of the astrocytes (HP:0100707)1.71180698
99Astrocytoma (HP:0009592)1.71180698
100Hemiparesis (HP:0001269)1.70224351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.58644670
2NUAK13.00432217
3EIF2AK33.00431893
4ZAK2.91127222
5LATS12.76302675
6BMPR1B2.58357865
7MAP4K22.36199570
8WNK32.24039702
9ERBB32.20053767
10TRIM282.15675534
11MST42.10914484
12STK392.09903898
13BCR1.95891626
14STK38L1.94921669
15CASK1.93224863
16ACVR1B1.91481590
17PBK1.76108116
18EIF2AK11.73796554
19OXSR11.67034533
20ADRBK21.58073960
21GRK11.53950356
22STK31.52288159
23PINK11.51611374
24INSRR1.46913829
25MAPK131.44410034
26PNCK1.28293670
27TXK1.27354572
28WNK41.23568981
29PLK21.21501451
30MAP3K41.15940625
31MKNK21.14150401
32TGFBR11.10117732
33PHKG11.02025501
34PHKG21.02025501
35BRSK21.01932135
36MUSK0.99603297
37PLK40.98744735
38CSNK1G10.98740468
39CCNB10.95234900
40CSNK1G30.95154346
41CSNK1A1L0.90627925
42WEE10.89492186
43PLK30.87646016
44VRK10.87177699
45NTRK30.85945475
46PRKCI0.84465775
47CSNK1G20.82947967
48STK160.80977377
49PDK20.79787839
50ADRBK10.79584179
51PRKCE0.79089304
52FGFR20.78542154
53FER0.77732290
54EIF2AK20.75305273
55STK240.74161701
56SRPK10.73750939
57BMPR20.73072408
58TLK10.72749240
59MAPKAPK30.71467788
60IRAK20.70051539
61IRAK10.69739952
62PAK30.67122679
63MELK0.63886021
64RPS6KA50.63436712
65MAP2K60.61555154
66RPS6KA40.61261829
67AKT30.58274410
68MKNK10.58232889
69TRPM70.55501915
70NEK60.53008857
71ATR0.50625817
72TTK0.48750231
73CHEK20.48186252
74CAMKK20.47191042
75PLK10.47094565
76PIK3CG0.46955928
77EPHA20.46716039
78PKN10.46538693
79TNIK0.45555588
80EPHA40.45495606
81PRKCG0.45203700
82CDC70.45025047
83EEF2K0.45006805
84TEC0.43651530
85ATM0.43098309
86MET0.42942389
87NEK20.41906786
88CDK80.40932966
89PTK2B0.39757563
90DYRK30.39099343
91PRKCQ0.38555935
92BUB10.37934382
93KSR10.37613929
94CSNK1A10.37130454
95CAMK1G0.37046451
96BCKDK0.36453281
97MST1R0.36369220
98PRKAA20.35618679
99PIM20.34994268
100CSNK1D0.34656240

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.54893340
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73206605
3Butanoate metabolism_Homo sapiens_hsa006502.50064405
4Phototransduction_Homo sapiens_hsa047442.32316830
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.31788902
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31584244
7Non-homologous end-joining_Homo sapiens_hsa034502.23056422
8Propanoate metabolism_Homo sapiens_hsa006402.14541683
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12169024
10Homologous recombination_Homo sapiens_hsa034402.08253081
11Basal transcription factors_Homo sapiens_hsa030222.07748945
12Tryptophan metabolism_Homo sapiens_hsa003802.07526285
13RNA polymerase_Homo sapiens_hsa030201.94385808
14Linoleic acid metabolism_Homo sapiens_hsa005911.93611966
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.90279580
16Fanconi anemia pathway_Homo sapiens_hsa034601.87077370
17Proteasome_Homo sapiens_hsa030501.85385566
18Protein export_Homo sapiens_hsa030601.84555079
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82127440
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76547175
21Ether lipid metabolism_Homo sapiens_hsa005651.73218481
22Selenocompound metabolism_Homo sapiens_hsa004501.61905817
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56499515
24Sphingolipid metabolism_Homo sapiens_hsa006001.54927705
25Taste transduction_Homo sapiens_hsa047421.49661007
26Nitrogen metabolism_Homo sapiens_hsa009101.49050517
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45179283
28Fatty acid elongation_Homo sapiens_hsa000621.44745342
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.43529806
30Oxidative phosphorylation_Homo sapiens_hsa001901.39112173
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36688191
32Peroxisome_Homo sapiens_hsa041461.26541684
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20480256
34RNA degradation_Homo sapiens_hsa030181.19808489
35Systemic lupus erythematosus_Homo sapiens_hsa053221.18506661
36One carbon pool by folate_Homo sapiens_hsa006701.17945300
37Vitamin B6 metabolism_Homo sapiens_hsa007501.15756182
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13225097
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11488991
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11023111
41Nucleotide excision repair_Homo sapiens_hsa034201.10147806
42Olfactory transduction_Homo sapiens_hsa047401.08076963
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07130291
44Mismatch repair_Homo sapiens_hsa034301.01974811
45Fatty acid degradation_Homo sapiens_hsa000711.00149631
46TGF-beta signaling pathway_Homo sapiens_hsa043500.95356008
47Steroid biosynthesis_Homo sapiens_hsa001000.92568251
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90461550
49Lysine degradation_Homo sapiens_hsa003100.86701708
50Nicotine addiction_Homo sapiens_hsa050330.86372199
51Sulfur metabolism_Homo sapiens_hsa009200.86246595
52Chemical carcinogenesis_Homo sapiens_hsa052040.86099543
53RNA transport_Homo sapiens_hsa030130.86095874
54Fatty acid metabolism_Homo sapiens_hsa012120.85186744
55Parkinsons disease_Homo sapiens_hsa050120.85146798
56Retinol metabolism_Homo sapiens_hsa008300.84420939
57ABC transporters_Homo sapiens_hsa020100.83189510
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82465131
59Regulation of autophagy_Homo sapiens_hsa041400.81252469
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.77576910
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76767199
62Alcoholism_Homo sapiens_hsa050340.76556467
63Arachidonic acid metabolism_Homo sapiens_hsa005900.74594885
64p53 signaling pathway_Homo sapiens_hsa041150.74360870
65beta-Alanine metabolism_Homo sapiens_hsa004100.73421364
66Circadian rhythm_Homo sapiens_hsa047100.73213507
67Metabolic pathways_Homo sapiens_hsa011000.72825887
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72812769
69Purine metabolism_Homo sapiens_hsa002300.71683872
70Huntingtons disease_Homo sapiens_hsa050160.71466167
71Fat digestion and absorption_Homo sapiens_hsa049750.69811933
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69492009
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.68669219
74Glycerolipid metabolism_Homo sapiens_hsa005610.68400562
75Primary immunodeficiency_Homo sapiens_hsa053400.61850354
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59373352
77Pyrimidine metabolism_Homo sapiens_hsa002400.59182137
78N-Glycan biosynthesis_Homo sapiens_hsa005100.58061098
79Histidine metabolism_Homo sapiens_hsa003400.55609987
80Fatty acid biosynthesis_Homo sapiens_hsa000610.52562395
81Base excision repair_Homo sapiens_hsa034100.50689839
82Collecting duct acid secretion_Homo sapiens_hsa049660.50068086
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49391815
84Hippo signaling pathway_Homo sapiens_hsa043900.47253417
85Pyruvate metabolism_Homo sapiens_hsa006200.45322901
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44455677
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.40088295
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.38626736
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37980198
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.36409089
91Alzheimers disease_Homo sapiens_hsa050100.36038777
92Dorso-ventral axis formation_Homo sapiens_hsa043200.35078187
93Hematopoietic cell lineage_Homo sapiens_hsa046400.33000138
94Basal cell carcinoma_Homo sapiens_hsa052170.32210969
95Arginine and proline metabolism_Homo sapiens_hsa003300.31617429
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.31609144
97Type I diabetes mellitus_Homo sapiens_hsa049400.30995476
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30806860
99Ovarian steroidogenesis_Homo sapiens_hsa049130.28787846
100Oocyte meiosis_Homo sapiens_hsa041140.28636564

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »