IGFL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IGFL3 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of keratinocyte proliferation (GO:0010839)9.23523094
2cell-substrate junction assembly (GO:0007044)9.04492518
3bundle of His cell to Purkinje myocyte communication (GO:0086069)9.00351033
4keratinocyte proliferation (GO:0043616)8.29218050
5keratinization (GO:0031424)8.07644455
6establishment of skin barrier (GO:0061436)7.94241333
7regulation of water loss via skin (GO:0033561)7.18509521
8regulation of keratinocyte proliferation (GO:0010837)6.85604572
9intermediate filament organization (GO:0045109)6.27810209
10molting cycle (GO:0042303)6.20744487
11hair cycle (GO:0042633)6.20744487
12cell adhesion mediated by integrin (GO:0033627)6.08878015
13dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.66343181
14epidermis development (GO:0008544)5.59880770
15regulation of hair follicle development (GO:0051797)5.41032041
16endodermal cell differentiation (GO:0035987)5.31508523
17surfactant homeostasis (GO:0043129)5.31351435
18keratinocyte development (GO:0003334)5.18273987
19ectoderm development (GO:0007398)5.15211610
20chemical homeostasis within a tissue (GO:0048875)4.62326845
21positive regulation of epidermis development (GO:0045684)4.55883932
22mesodermal cell differentiation (GO:0048333)4.45722076
23positive regulation of hair follicle development (GO:0051798)4.41557413
24positive regulation of hair cycle (GO:0042635)4.41557413
25intermediate filament cytoskeleton organization (GO:0045104)4.41354976
26peptidyl-tyrosine autophosphorylation (GO:0038083)4.39706436
27intermediate filament-based process (GO:0045103)4.27179583
28gap junction assembly (GO:0016264)4.23595997
29multicellular organismal water homeostasis (GO:0050891)4.21505939
30regulation of hair cycle (GO:0042634)4.10033888
31positive regulation of epidermal cell differentiation (GO:0045606)4.09084456
32lateral sprouting from an epithelium (GO:0060601)4.06279954
33keratinocyte differentiation (GO:0030216)4.06200327
34regulation of transforming growth factor beta2 production (GO:0032909)4.04115168
35polarized epithelial cell differentiation (GO:0030859)3.85482621
36establishment of planar polarity (GO:0001736)3.77817817
37establishment of tissue polarity (GO:0007164)3.77817817
38glial cell proliferation (GO:0014009)3.74187498
39renal system development (GO:0072001)3.71103441
40negative regulation of chondrocyte differentiation (GO:0032331)3.68467046
41cell junction assembly (GO:0034329)3.67694839
42skin development (GO:0043588)3.57840793
43renal filtration (GO:0097205)3.54376027
44regulation of epidermis development (GO:0045682)3.49374031
45cardiac right ventricle morphogenesis (GO:0003215)3.49253362
46water homeostasis (GO:0030104)3.49055812
47mammary gland development (GO:0030879)3.45901101
48negative regulation of epidermis development (GO:0045683)3.45817706
49regulation of transforming growth factor beta1 production (GO:0032908)3.44430261
50cell junction organization (GO:0034330)3.41962698
51heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.32026021
52epidermal cell differentiation (GO:0009913)3.31754793
53gland morphogenesis (GO:0022612)3.31048452
54neural crest cell development (GO:0014032)3.30298426
55positive regulation of keratinocyte differentiation (GO:0045618)3.26934219
56extracellular matrix disassembly (GO:0022617)3.23207334
57cellular copper ion homeostasis (GO:0006878)3.20331618
58cellular response to vitamin D (GO:0071305)3.17118319
59positive regulation of interleukin-8 secretion (GO:2000484)3.16277596
60ventricular trabecula myocardium morphogenesis (GO:0003222)3.14844597
61positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.14007423
62regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.14007423
63type B pancreatic cell proliferation (GO:0044342)3.12538158
64ventricular cardiac muscle cell action potential (GO:0086005)3.03143705
65L-serine transport (GO:0015825)3.01287553
66regulation of transforming growth factor beta production (GO:0071634)3.00251483
67hemidesmosome assembly (GO:0031581)25.0428699
68hypotonic response (GO:0006971)2.99845888
69protein localization to endosome (GO:0036010)2.98483068
70epithelial cell differentiation involved in prostate gland development (GO:0060742)2.90892585
71cell communication involved in cardiac conduction (GO:0086065)2.85447345
72epithelium development (GO:0060429)2.83564997
73skin morphogenesis (GO:0043589)2.79865230
74cellular response to vitamin (GO:0071295)2.78778272
75facial nerve structural organization (GO:0021612)2.78703561
76axon extension involved in axon guidance (GO:0048846)2.77329366
77neuron projection extension involved in neuron projection guidance (GO:1902284)2.77329366
78hair follicle morphogenesis (GO:0031069)2.76199730
79regulation of keratinocyte differentiation (GO:0045616)2.70956620
80heparan sulfate proteoglycan metabolic process (GO:0030201)2.70592092
81regulation of heart rate by cardiac conduction (GO:0086091)2.65501459
82mesenchymal cell development (GO:0014031)2.61768446
83regulation of protein heterodimerization activity (GO:0043497)2.60684114
84serine transport (GO:0032329)2.59997323
85positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.58414461
86negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.57233731
87negative regulation of cartilage development (GO:0061037)2.57009823
88hair cycle process (GO:0022405)2.55656772
89molting cycle process (GO:0022404)2.55656772
90negative regulation of axon extension involved in axon guidance (GO:0048843)2.53911478
91wound healing (GO:0042060)2.52725839
92negative chemotaxis (GO:0050919)2.52568367
93cytoskeletal anchoring at plasma membrane (GO:0007016)2.51155626
94positive regulation of positive chemotaxis (GO:0050927)2.49387364
95mammary gland epithelial cell proliferation (GO:0033598)2.47887338
96establishment of epithelial cell polarity (GO:0090162)2.47180576
97positive regulation of cellular amide metabolic process (GO:0034250)2.44760080
98positive regulation of glomerulus development (GO:0090193)2.43566652
99Sertoli cell development (GO:0060009)2.42577407
100desmosome organization (GO:0002934)11.5067297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.23726221
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.59987389
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.88911633
4P63_26484246_Chip-Seq_KERATINOCYTES_Human2.77530654
5SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.73278563
6SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.73278563
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.59072313
8SOX9_24532713_ChIP-Seq_HFSC_Mouse2.04234745
9* TP63_23658742_ChIP-Seq_EP156T_Human2.01957380
10TP63_17297297_ChIP-ChIP_HaCaT_Human18.7293396
11TP53_18474530_ChIP-ChIP_U2OS_Human1.74927025
12CJUN_26792858_Chip-Seq_BT549_Human1.54346862
13TCF4_18268006_ChIP-ChIP_LS174T_Human1.51461807
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51404299
15UBF1/2_26484160_Chip-Seq_HMECs_Human1.46032655
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36840504
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32228808
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26728560
19ZNF263_19887448_ChIP-Seq_K562_Human1.23452598
20TAF15_26573619_Chip-Seq_HEK293_Human1.20683763
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.18626780
22SOX2_20726797_ChIP-Seq_SW620_Human1.17757512
23EGR1_19032775_ChIP-ChIP_M12_Human1.16948406
24TP63_22573176_ChIP-Seq_HFKS_Human1.14214149
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09569173
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05774143
27ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05284890
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03020230
29JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02613978
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.01223524
31FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01145981
32AR_21572438_ChIP-Seq_LNCaP_Human1.00604690
33SMAD3_21741376_ChIP-Seq_HESCs_Human1.00488741
34TP53_16413492_ChIP-PET_HCT116_Human0.98912702
35TRIM28_21343339_ChIP-Seq_HEK293_Human0.98333010
36ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96326276
37AHR_22903824_ChIP-Seq_MCF-7_Human0.95654535
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94343132
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94221648
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94041718
41JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92358056
42RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92156376
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91160837
44GATA2_21666600_ChIP-Seq_HMVEC_Human0.91066003
45ESR2_21235772_ChIP-Seq_MCF-7_Human0.90883928
46ARNT_22903824_ChIP-Seq_MCF-7_Human0.89561058
47RXR_22108803_ChIP-Seq_LS180_Human0.89556732
48ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89386835
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87891427
50SALL1_21062744_ChIP-ChIP_HESCs_Human0.85350070
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81106443
52NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81106443
53ATF3_27146783_Chip-Seq_COLON_Human0.80782445
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80617865
55IGF1R_20145208_ChIP-Seq_DFB_Human0.79160081
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78815279
57BRD4_25478319_ChIP-Seq_HGPS_Human0.77800080
58SMAD4_21799915_ChIP-Seq_A2780_Human0.71540723
59P300_27058665_Chip-Seq_ZR-75-30cells_Human0.71051886
60BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69112919
61CLOCK_20551151_ChIP-Seq_293T_Human0.68509420
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.68474674
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.68182310
64PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.67809753
65KLF5_25053715_ChIP-Seq_YYC3_Human0.67479314
66GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.65015498
67SMAD3_21741376_ChIP-Seq_EPCs_Human0.64743017
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.64459559
69P53_22127205_ChIP-Seq_FIBROBLAST_Human0.61886847
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.60619959
71GATA3_24758297_ChIP-Seq_MCF-7_Human0.59770553
72NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.58058290
73* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.56895480
74ESR1_21235772_ChIP-Seq_MCF-7_Human0.56856887
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.56251750
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.55920316
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.55846882
78ZFP57_27257070_Chip-Seq_ESCs_Mouse0.54135915
79PCGF2_27294783_Chip-Seq_NPCs_Mouse0.53616950
80GATA4_25053715_ChIP-Seq_YYC3_Human0.53305614
81TBX20_22080862_ChIP-Seq_HEART_Mouse0.52081007
82TBX20_22328084_ChIP-Seq_HEART_Mouse0.52081007
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.51728196
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.50296262
85NOTCH1_21737748_ChIP-Seq_TLL_Human0.49698968
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.49130694
87RARG_19884340_ChIP-ChIP_MEFs_Mouse0.48839507
88* CDX2_22108803_ChIP-Seq_LS180_Human0.48806467
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.48529452
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.48106371
91TP53_23651856_ChIP-Seq_MEFs_Mouse0.48102341
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.47790252
93TBL1_22424771_ChIP-Seq_293T_Human0.47297923
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.47097793
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.46302144
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.45908045
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.45525481
98TET1_21490601_ChIP-Seq_MESCs_Mouse0.45506871
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.45368383
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.44639523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.35331862
2MP0010234_abnormal_vibrissa_follicle4.05941177
3MP0005275_abnormal_skin_tensile4.04223648
4MP0000467_abnormal_esophagus_morphology3.71127721
5MP0002796_impaired_skin_barrier3.68089029
6MP0000762_abnormal_tongue_morphology3.54370832
7MP0004272_abnormal_basement_membrane3.30465218
8MP0010678_abnormal_skin_adnexa3.20091333
9MP0004381_abnormal_hair_follicle3.17601843
10MP0000383_abnormal_hair_follicle3.12788569
11MP0002098_abnormal_vibrissa_morphology3.07146915
12MP0002060_abnormal_skin_morphology3.05297288
13MP0002234_abnormal_pharynx_morphology3.00817475
14MP0001216_abnormal_epidermal_layer2.90853641
15MP0005409_darkened_coat_color2.80109800
16MP0001849_ear_inflammation2.77176308
17MP0000566_synostosis2.72403292
18MP0003566_abnormal_cell_adhesion2.71637313
19MP0005501_abnormal_skin_physiology2.34356675
20MP0003453_abnormal_keratinocyte_physiol2.29793904
21MP0000377_abnormal_hair_follicle2.15307509
22MP0010771_integument_phenotype2.08926555
23MP0000579_abnormal_nail_morphology10.6121494
24MP0009053_abnormal_anal_canal1.80053788
25MP0008260_abnormal_autophagy1.57979305
26MP0008789_abnormal_olfactory_epithelium1.53164946
27MP0000537_abnormal_urethra_morphology1.52500724
28MP0004264_abnormal_extraembryonic_tissu1.46116762
29MP0009931_abnormal_skin_appearance1.36823783
30MP0003705_abnormal_hypodermis_morpholog1.35205855
31MP0000678_abnormal_parathyroid_gland1.31387664
32MP0005499_abnormal_olfactory_system1.29415935
33MP0005394_taste/olfaction_phenotype1.29415935
34MP0000427_abnormal_hair_cycle1.25982513
35MP0005023_abnormal_wound_healing1.23793191
36MP0001191_abnormal_skin_condition1.22484447
37MP0000367_abnormal_coat/_hair1.19655341
38MP0000538_abnormal_urinary_bladder1.17486776
39MP0005360_urolithiasis1.10921380
40MP0003315_abnormal_perineum_morphology1.10628504
41MP0004947_skin_inflammation1.07756258
42MP0003191_abnormal_cellular_cholesterol1.03946628
43MP0000627_abnormal_mammary_gland1.02968879
44MP0003755_abnormal_palate_morphology1.02042996
45MP0004782_abnormal_surfactant_physiolog1.01857535
46MP0001299_abnormal_eye_distance/1.00702652
47MP0003329_amyloid_beta_deposits1.00153030
48MP0000569_abnormal_digit_pigmentation0.98344179
49MP0005257_abnormal_intraocular_pressure0.90069423
50MP0000647_abnormal_sebaceous_gland0.88428976
51MP0002177_abnormal_outer_ear0.72243999
52MP0002282_abnormal_trachea_morphology0.71126686
53MP0004019_abnormal_vitamin_homeostasis0.70768660
54MP0000462_abnormal_digestive_system0.68690879
55MP0009780_abnormal_chondrocyte_physiolo0.64866924
56MP0001340_abnormal_eyelid_morphology0.62969483
57MP0003385_abnormal_body_wall0.58900805
58MP0003950_abnormal_plasma_membrane0.58632003
59MP0002233_abnormal_nose_morphology0.58371008
60MP0006138_congestive_heart_failure0.53775693
61MP0000858_altered_metastatic_potential0.52192446
62MP0002896_abnormal_bone_mineralization0.51495856
63MP0000432_abnormal_head_morphology0.50844576
64MP0002697_abnormal_eye_size0.50605282
65MP0002295_abnormal_pulmonary_circulatio0.50466136
66MP0004885_abnormal_endolymph0.49929313
67MP0004270_analgesia0.48698786
68MP0001851_eye_inflammation0.48479270
69MP0005197_abnormal_uvea_morphology0.47546035
70MP0002089_abnormal_postnatal_growth/wei0.46586119
71MP0001177_atelectasis0.43826718
72MP0003045_fibrosis0.42944672
73MP0009384_cardiac_valve_regurgitation0.42749584
74MP0005193_abnormal_anterior_eye0.42743572
75MP0000778_abnormal_nervous_system0.42054539
76MP0003091_abnormal_cell_migration0.41644966
77MP0003183_abnormal_peptide_metabolism0.40063394
78MP0003935_abnormal_craniofacial_develop0.39234362
79MP0002111_abnormal_tail_morphology0.35928127
80MP0010368_abnormal_lymphatic_system0.34772615
81MP0004858_abnormal_nervous_system0.34225678
82MP0001243_abnormal_dermal_layer0.34191436
83MP0008438_abnormal_cutaneous_collagen0.33817293
84MP0005075_abnormal_melanosome_morpholog0.33655157
85MP0001765_abnormal_ion_homeostasis0.32441380
86MP0001958_emphysema0.32245358
87MP0000604_amyloidosis0.31649713
88MP0003936_abnormal_reproductive_system0.31604595
89MP0010030_abnormal_orbit_morphology0.31518400
90MP0005388_respiratory_system_phenotype0.31338724
91MP0002133_abnormal_respiratory_system0.31338724
92MP0001784_abnormal_fluid_regulation0.30495176
93MP0004134_abnormal_chest_morphology0.29777314
94MP0005623_abnormal_meninges_morphology0.28767675
95MP0003634_abnormal_glial_cell0.27846516
96MP0005621_abnormal_cell_physiology0.27042395
97MP0004197_abnormal_fetal_growth/weight/0.26988353
98MP0005248_abnormal_Harderian_gland0.26176250
99MP0003786_premature_aging0.26016192
100MP0000470_abnormal_stomach_morphology0.25461148

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)9.41119248
2Plantar hyperkeratosis (HP:0007556)9.29584724
3Atrophic scars (HP:0001075)9.13052693
4Thick nail (HP:0001805)6.93421967
5Palmoplantar hyperkeratosis (HP:0000972)5.86068196
6Nail dystrophy (HP:0008404)5.77790124
7Palmar hyperkeratosis (HP:0010765)5.65365140
8Alopecia of scalp (HP:0002293)5.34732027
9Ridged nail (HP:0001807)4.81998020
10Abnormal blistering of the skin (HP:0008066)4.71669581
11Pili torti (HP:0003777)4.71428642
12Right ventricular cardiomyopathy (HP:0011663)4.66812421
13Hypoplasia of dental enamel (HP:0006297)4.60648707
14Pterygium (HP:0001059)3.95784764
15Aplasia cutis congenita (HP:0001057)3.89564065
16Abnormal hair laboratory examination (HP:0003328)3.83148100
17Sparse scalp hair (HP:0002209)3.67162238
18Hypotrichosis (HP:0001006)3.53662955
19Woolly hair (HP:0002224)3.48883268
20Fragile skin (HP:0001030)3.44623152
21Selective tooth agenesis (HP:0001592)3.43873290
22Natal tooth (HP:0000695)3.30088174
23Dry hair (HP:0011359)3.20395433
24Anonychia (HP:0001798)3.18861063
25Esophageal atresia (HP:0002032)3.17980694
26Oral leukoplakia (HP:0002745)3.09850420
27Hypodontia (HP:0000668)3.02207912
28Follicular hyperkeratosis (HP:0007502)2.94071988
29Hyperhidrosis (HP:0000975)2.93812271
30Sparse eyelashes (HP:0000653)2.83446882
31Carious teeth (HP:0000670)2.83153115
32Laryngomalacia (HP:0001601)2.64921645
33Hypoplastic labia majora (HP:0000059)2.64906749
34Ectropion (HP:0000656)2.59008956
35Neurofibrillary tangles (HP:0002185)2.57709643
36Lip pit (HP:0100267)2.50960623
37Parakeratosis (HP:0001036)2.46248536
38Popliteal pterygium (HP:0009756)2.44545091
39Palmoplantar keratoderma (HP:0000982)2.44196223
40Erythema (HP:0010783)2.42826860
41Advanced eruption of teeth (HP:0006288)2.41426421
42Abnormality of the labia majora (HP:0012881)2.38033051
43Ankyloglossia (HP:0010296)2.36693836
44Corneal dystrophy (HP:0001131)2.35714181
45Abnormality of the neuromuscular junction (HP:0003398)2.34036602
46Fatigable weakness (HP:0003473)2.34036602
47Abnormality of secondary sexual hair (HP:0009888)2.33599850
48Abnormality of the axillary hair (HP:0100134)2.33599850
49Abnormality of the fingernails (HP:0001231)2.29945622
50Amelogenesis imperfecta (HP:0000705)2.27675783
51Corneal erosion (HP:0200020)2.25069303
52Oligodontia (HP:0000677)2.22418501
53Abnormality of placental membranes (HP:0011409)2.18034593
54Amniotic constriction ring (HP:0009775)2.18034593
55Ureteral stenosis (HP:0000071)2.17913180
56Absent eyelashes (HP:0000561)2.10680555
57Dehydration (HP:0001944)2.09599506
58Ureteral obstruction (HP:0006000)2.04228808
59Death in infancy (HP:0001522)2.04068361
60Fragile nails (HP:0001808)11.2678447
61Milia (HP:0001056)11.2361953
62Onycholysis (HP:0001806)10.7366296
63Blepharitis (HP:0000498)1.95796431
64Cerebral inclusion bodies (HP:0100314)1.94819791
65Congenital ichthyosiform erythroderma (HP:0007431)1.94231186
66Abnormality of oral frenula (HP:0000190)1.94002432
67Abnormality of the salivary glands (HP:0010286)1.88293899
68Epidermoid cyst (HP:0200040)1.85903583
69Erythroderma (HP:0001019)1.85789620
70Septate vagina (HP:0001153)1.84992687
71Hoarse voice (HP:0001609)1.82119685
72Labial hypoplasia (HP:0000066)1.79015396
73Hypohidrosis (HP:0000966)1.78009690
74Cheilitis (HP:0100825)1.71982011
75Skin ulcer (HP:0200042)1.68994042
76Hypoplastic female external genitalia (HP:0012815)1.63540359
77Gastrointestinal atresia (HP:0002589)1.61653057
78Premature loss of primary teeth (HP:0006323)1.58043228
79Abnormality of the alveolar ridges (HP:0006477)1.57035202
80Squamous cell carcinoma (HP:0002860)1.55384126
81Vertebral arch anomaly (HP:0008438)1.49880636
82Hip dysplasia (HP:0001385)1.42605471
83Pustule (HP:0200039)1.42439319
84Pyloric stenosis (HP:0002021)1.40464080
85Arterial tortuosity (HP:0005116)1.39500634
86Back pain (HP:0003418)1.38998335
87Increased IgE level (HP:0003212)1.35709316
88Xerostomia (HP:0000217)1.33329523
89Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.31250395
90Curly hair (HP:0002212)1.30949005
91Breast hypoplasia (HP:0003187)1.30128822
92Hypoplasia of the uterus (HP:0000013)1.29797496
93Conical tooth (HP:0000698)1.27882051
94Abnormality of the gastric mucosa (HP:0004295)1.26625309
95Tibial bowing (HP:0002982)1.26536237
96Periodontitis (HP:0000704)1.26053045
97Camptodactyly of finger (HP:0100490)1.24147709
98Global brain atrophy (HP:0002283)1.23807617
99Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.23382990
100Ventricular tachycardia (HP:0004756)1.23035385

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF7.23380800
2PIM25.46750135
3EPHB23.81680335
4MST1R3.69378149
5EPHA23.64610791
6SIK13.37290920
7MAP3K23.36625700
8KSR23.04289044
9NTRK12.77209193
10RAF12.49393997
11MET2.47886608
12BRAF2.38268416
13RIPK12.20863710
14CASK2.16330940
15TGFBR11.76027944
16MAP3K91.68548302
17STK241.67301354
18LATS21.46192722
19EPHA41.43892887
20FER1.38404579
21PTK21.33809248
22TGFBR21.29277497
23RPS6KA21.22454545
24MARK11.21751625
25FLT31.11211882
26LATS11.10813738
27CSF1R1.09689376
28PRKCE0.97953174
29ROCK20.92509327
30PAK40.92128545
31MAPKAPK30.91805793
32PDGFRA0.91453961
33KSR10.89592849
34EPHB10.89177100
35PRKCI0.86668588
36MAP3K10.82702284
37WNK30.82382814
38TRIM280.76081185
39PIK3CG0.74259160
40ADRBK10.71239522
41LMTK20.70485153
42RPS6KA10.69920103
43STK38L0.69619079
44BCR0.68458886
45PRKD30.65465478
46ERBB20.63466719
47MAP2K10.61683019
48MAP3K30.59885975
49ERN10.59791265
50RET0.57816814
51PRKD20.57246307
52RPS6KC10.56163215
53RPS6KL10.56163215
54GRK10.54794965
55CAMK1G0.51761007
56PDGFRB0.51571884
57TTN0.48718085
58RPS6KA60.46693024
59CDK120.46588514
60PAK30.44395077
61MAP3K120.44246040
62INSR0.43640800
63NEK60.43527350
64BMX0.43186546
65STK380.42987785
66ROCK10.41771963
67MAPKAPK50.40897119
68MATK0.38634523
69ABL20.35869560
70MAP2K20.35563316
71CAMK2G0.35199285
72MAP3K60.34727095
73PRKD10.33000398
74PNCK0.31790622
75PIM10.30939387
76MAP4K20.30562830
77MTOR0.30072269
78INSRR0.28739527
79TRPM70.27510653
80DYRK30.27280863
81TSSK60.26391954
82ADRBK20.25006222
83PAK20.24975829
84IKBKB0.23560079
85EIF2AK20.23252105
86EIF2AK30.23127366
87TAOK10.22696127
88AKT30.22581736
89IGF1R0.21856797
90MAP3K80.21574401
91RPS6KB10.21435841
92ABL10.20844204
93WNK10.20456868
94CDC42BPA0.20399401
95ILK0.19660357
96FYN0.19283568
97PLK20.18829912
98ERBB30.18637508
99PRKCQ0.18039804
100JAK10.16708931

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.14606794
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.65191401
3Small cell lung cancer_Homo sapiens_hsa052223.25243931
4Steroid biosynthesis_Homo sapiens_hsa001002.98589455
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.66738850
6Focal adhesion_Homo sapiens_hsa045102.39831475
7Amoebiasis_Homo sapiens_hsa051462.31521441
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.29782297
9Sphingolipid metabolism_Homo sapiens_hsa006001.87659712
10p53 signaling pathway_Homo sapiens_hsa041151.86581795
11ErbB signaling pathway_Homo sapiens_hsa040121.84174142
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.83733564
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.81317583
14Toxoplasmosis_Homo sapiens_hsa051451.73659079
15Dorso-ventral axis formation_Homo sapiens_hsa043201.67822079
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.67305610
17Axon guidance_Homo sapiens_hsa043601.67275459
18Adherens junction_Homo sapiens_hsa045201.61988547
19Dilated cardiomyopathy_Homo sapiens_hsa054141.57189711
20Bladder cancer_Homo sapiens_hsa052191.41664218
21Proteoglycans in cancer_Homo sapiens_hsa052051.33730090
22Regulation of actin cytoskeleton_Homo sapiens_hsa048101.30776155
23Protein digestion and absorption_Homo sapiens_hsa049741.30134993
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.25479722
25Renin secretion_Homo sapiens_hsa049241.25050828
26PI3K-Akt signaling pathway_Homo sapiens_hsa041511.22892725
27Ether lipid metabolism_Homo sapiens_hsa005651.21641381
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21006731
29Melanoma_Homo sapiens_hsa052181.18948279
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17063175
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15501300
32Phototransduction_Homo sapiens_hsa047441.14888810
33Pathways in cancer_Homo sapiens_hsa052001.11625006
34Glioma_Homo sapiens_hsa052141.08615719
35Endometrial cancer_Homo sapiens_hsa052131.07703635
36Prion diseases_Homo sapiens_hsa050201.07448092
37Long-term depression_Homo sapiens_hsa047301.05696174
38Thyroid cancer_Homo sapiens_hsa052161.04748658
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.03786779
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98626160
41Notch signaling pathway_Homo sapiens_hsa043300.96466368
42VEGF signaling pathway_Homo sapiens_hsa043700.95544881
43Hippo signaling pathway_Homo sapiens_hsa043900.94938155
44Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93585270
45MicroRNAs in cancer_Homo sapiens_hsa052060.92114276
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89565094
47Chronic myeloid leukemia_Homo sapiens_hsa052200.89282386
48Inositol phosphate metabolism_Homo sapiens_hsa005620.89227524
49GnRH signaling pathway_Homo sapiens_hsa049120.86679536
50Glycerolipid metabolism_Homo sapiens_hsa005610.84366601
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75426232
52Acute myeloid leukemia_Homo sapiens_hsa052210.74003252
53Melanogenesis_Homo sapiens_hsa049160.73001366
54Lysosome_Homo sapiens_hsa041420.71744926
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71304143
56Tight junction_Homo sapiens_hsa045300.71014676
57Pancreatic cancer_Homo sapiens_hsa052120.70719917
58TGF-beta signaling pathway_Homo sapiens_hsa043500.70556204
59N-Glycan biosynthesis_Homo sapiens_hsa005100.69913910
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68156245
61Insulin signaling pathway_Homo sapiens_hsa049100.66295522
62Basal cell carcinoma_Homo sapiens_hsa052170.64323681
63Prostate cancer_Homo sapiens_hsa052150.61793674
64Pancreatic secretion_Homo sapiens_hsa049720.59941531
65Estrogen signaling pathway_Homo sapiens_hsa049150.59287439
66Ovarian steroidogenesis_Homo sapiens_hsa049130.58793285
67Gap junction_Homo sapiens_hsa045400.56138882
68Linoleic acid metabolism_Homo sapiens_hsa005910.56117206
69Renal cell carcinoma_Homo sapiens_hsa052110.55566399
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54993468
71Serotonergic synapse_Homo sapiens_hsa047260.53113825
72Non-small cell lung cancer_Homo sapiens_hsa052230.52084382
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.51530200
74Vitamin digestion and absorption_Homo sapiens_hsa049770.50464876
75Rap1 signaling pathway_Homo sapiens_hsa040150.48522029
76Colorectal cancer_Homo sapiens_hsa052100.48413822
77Hepatitis C_Homo sapiens_hsa051600.48264133
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47861949
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.46934795
80Apoptosis_Homo sapiens_hsa042100.44935637
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44330888
82Shigellosis_Homo sapiens_hsa051310.44174673
83FoxO signaling pathway_Homo sapiens_hsa040680.44001257
84Hedgehog signaling pathway_Homo sapiens_hsa043400.43539579
85Fatty acid elongation_Homo sapiens_hsa000620.42573758
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41380415
87Long-term potentiation_Homo sapiens_hsa047200.41136186
88Gastric acid secretion_Homo sapiens_hsa049710.41005081
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40412206
90Mineral absorption_Homo sapiens_hsa049780.39777358
91Ras signaling pathway_Homo sapiens_hsa040140.38353035
92Phagosome_Homo sapiens_hsa041450.37727841
93Endocytosis_Homo sapiens_hsa041440.37231959
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35481571
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.34604903
96Type II diabetes mellitus_Homo sapiens_hsa049300.34506589
97Salivary secretion_Homo sapiens_hsa049700.33322499
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32405648
99Salmonella infection_Homo sapiens_hsa051320.30200561
100Glutamatergic synapse_Homo sapiens_hsa047240.28308147

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