IGFL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IGFL4 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indolalkylamine metabolic process (GO:0006586)4.87529252
2indole-containing compound catabolic process (GO:0042436)4.85036005
3indolalkylamine catabolic process (GO:0046218)4.85036005
4tryptophan catabolic process (GO:0006569)4.85036005
5detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.74783789
6cilium or flagellum-dependent cell motility (GO:0001539)4.40098655
7tryptophan metabolic process (GO:0006568)4.30427779
8neural tube formation (GO:0001841)4.29120444
9kynurenine metabolic process (GO:0070189)4.21425424
10photoreceptor cell maintenance (GO:0045494)4.15767438
11signal peptide processing (GO:0006465)4.15345535
12behavioral response to ethanol (GO:0048149)4.08280711
13negative regulation of cytosolic calcium ion concentration (GO:0051481)3.97008105
14regulation of hippo signaling (GO:0035330)3.76995050
15detection of light stimulus involved in sensory perception (GO:0050962)3.74679048
16detection of light stimulus involved in visual perception (GO:0050908)3.74679048
17establishment of protein localization to Golgi (GO:0072600)3.66748045
18indole-containing compound metabolic process (GO:0042430)3.57771577
19cellular ketone body metabolic process (GO:0046950)3.53608349
20reflex (GO:0060004)3.47530583
21behavioral response to nicotine (GO:0035095)3.46668504
22tachykinin receptor signaling pathway (GO:0007217)3.45026133
23L-fucose catabolic process (GO:0042355)3.44354401
24fucose catabolic process (GO:0019317)3.44354401
25L-fucose metabolic process (GO:0042354)3.44354401
26DNA double-strand break processing (GO:0000729)3.38168299
27protein K11-linked deubiquitination (GO:0035871)3.32208816
28regulation of sarcomere organization (GO:0060297)3.31944574
29piRNA metabolic process (GO:0034587)3.28511575
30auditory receptor cell stereocilium organization (GO:0060088)3.25116473
31negative regulation of calcium ion transport into cytosol (GO:0010523)3.21256873
32detection of mechanical stimulus involved in sensory perception (GO:0050974)3.19227115
33monoubiquitinated protein deubiquitination (GO:0035520)3.18034566
34serotonin metabolic process (GO:0042428)3.15668570
35cellular biogenic amine catabolic process (GO:0042402)3.15392830
36amine catabolic process (GO:0009310)3.15392830
37gamma-aminobutyric acid transport (GO:0015812)3.15024561
38response to pheromone (GO:0019236)3.14976211
39ketone body metabolic process (GO:1902224)3.14048269
40retinal cone cell development (GO:0046549)3.12239151
41benzene-containing compound metabolic process (GO:0042537)3.06032593
42positive regulation of developmental pigmentation (GO:0048087)3.05602425
43axoneme assembly (GO:0035082)3.03064657
44negative regulation of mast cell activation (GO:0033004)3.02389448
45interkinetic nuclear migration (GO:0022027)3.01799429
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.00015414
47primary amino compound metabolic process (GO:1901160)2.98442907
48protein prenylation (GO:0018342)2.98293860
49prenylation (GO:0097354)2.98293860
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86001393
51NAD biosynthetic process (GO:0009435)2.82783163
52protein K48-linked deubiquitination (GO:0071108)2.78611773
53inner ear receptor stereocilium organization (GO:0060122)2.78090587
54sulfation (GO:0051923)2.77180577
55thyroid hormone metabolic process (GO:0042403)2.77060399
56sphingoid metabolic process (GO:0046519)2.76983555
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.74773282
58regulation of pigment cell differentiation (GO:0050932)2.74633199
59neuronal action potential (GO:0019228)2.74501788
60DNA methylation involved in gamete generation (GO:0043046)2.74204337
61protein targeting to Golgi (GO:0000042)2.71345076
62cellular response to sterol (GO:0036315)2.71105600
63phospholipid translocation (GO:0045332)2.69403024
64lipid translocation (GO:0034204)2.69403024
65regulation of gene silencing by RNA (GO:0060966)2.67808171
66regulation of posttranscriptional gene silencing (GO:0060147)2.67808171
67regulation of gene silencing by miRNA (GO:0060964)2.67808171
68replication fork processing (GO:0031297)2.67476992
69protein K63-linked deubiquitination (GO:0070536)2.67205510
70snRNA transcription (GO:0009301)2.67096975
71central nervous system neuron axonogenesis (GO:0021955)2.66885879
72transmission of nerve impulse (GO:0019226)2.66386306
73cilium morphogenesis (GO:0060271)2.65328766
74regulation of acrosome reaction (GO:0060046)2.62546986
75membrane depolarization during action potential (GO:0086010)2.62275961
76cilium movement (GO:0003341)2.61934792
77aromatic amino acid family catabolic process (GO:0009074)2.60190049
78proline transport (GO:0015824)2.59386473
79cilium organization (GO:0044782)2.58691041
80aromatic amino acid family metabolic process (GO:0009072)2.57668966
81UDP-N-acetylglucosamine metabolic process (GO:0006047)2.54577381
82protein localization to cilium (GO:0061512)2.53971029
83cilium assembly (GO:0042384)2.53495187
84dicarboxylic acid catabolic process (GO:0043649)2.53442132
85double-strand break repair via homologous recombination (GO:0000724)2.51558856
86retrograde transport, vesicle recycling within Golgi (GO:0000301)2.51541498
87recombinational repair (GO:0000725)2.50928585
88epithelial cilium movement (GO:0003351)2.50647505
89gene silencing by RNA (GO:0031047)2.49888703
90protein polyglutamylation (GO:0018095)2.48898191
91amino acid salvage (GO:0043102)2.48876231
92L-methionine salvage (GO:0071267)2.48876231
93L-methionine biosynthetic process (GO:0071265)2.48876231
94positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.47878146
95righting reflex (GO:0060013)2.47853147
96phosphatidylinositol acyl-chain remodeling (GO:0036149)2.47696871
97histone H3-K9 methylation (GO:0051567)2.47348203
98dopamine transport (GO:0015872)2.46931587
99C4-dicarboxylate transport (GO:0015740)2.45455447
100detection of mechanical stimulus (GO:0050982)2.45109957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.71753186
2ZNF274_21170338_ChIP-Seq_K562_Hela3.09189062
3IGF1R_20145208_ChIP-Seq_DFB_Human2.95648715
4VDR_22108803_ChIP-Seq_LS180_Human2.93463418
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73296171
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.72965748
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.72247575
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54492820
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.51578384
10EZH2_22144423_ChIP-Seq_EOC_Human2.50492979
11TAF15_26573619_Chip-Seq_HEK293_Human2.46619906
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.36059359
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.26049407
14P300_19829295_ChIP-Seq_ESCs_Human2.17091693
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.11422055
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.11243619
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.07986467
18FUS_26573619_Chip-Seq_HEK293_Human2.05907364
19ER_23166858_ChIP-Seq_MCF-7_Human2.03736813
20EWS_26573619_Chip-Seq_HEK293_Human2.03009133
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98458363
22* STAT3_23295773_ChIP-Seq_U87_Human1.94246493
23SMAD4_21799915_ChIP-Seq_A2780_Human1.90338971
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.89900118
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80894699
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78775911
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.76809419
28CBP_20019798_ChIP-Seq_JUKART_Human1.74888202
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.74888202
30BCAT_22108803_ChIP-Seq_LS180_Human1.72626535
31TCF4_23295773_ChIP-Seq_U87_Human1.71130810
32* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69470317
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.64002874
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59326827
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54713821
36POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54598367
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54598367
38AR_25329375_ChIP-Seq_VCAP_Human1.53669475
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.50817120
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46098983
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.44763176
42AR_21572438_ChIP-Seq_LNCaP_Human1.44444129
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43807553
44TCF4_22108803_ChIP-Seq_LS180_Human1.43313839
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42951808
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42658716
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38959588
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38651705
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38549145
50PRDM14_20953172_ChIP-Seq_ESCs_Human1.37751421
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36759095
52RUNX2_22187159_ChIP-Seq_PCA_Human1.35716817
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34650173
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32571869
55TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32012129
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.32001878
57SOX2_19829295_ChIP-Seq_ESCs_Human1.29700871
58NANOG_19829295_ChIP-Seq_ESCs_Human1.29700871
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28277388
60FLI1_21867929_ChIP-Seq_TH2_Mouse1.27129379
61TP53_22573176_ChIP-Seq_HFKS_Human1.27084311
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27035328
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26982804
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26187183
65TP53_16413492_ChIP-PET_HCT116_Human1.25877573
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.25775469
67CDX2_22108803_ChIP-Seq_LS180_Human1.25530125
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24199184
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.23657708
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23528939
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21240435
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.20830890
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19727062
74DROSHA_22980978_ChIP-Seq_HELA_Human1.18952725
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18332986
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16360253
77REST_21632747_ChIP-Seq_MESCs_Mouse1.16321521
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.13853827
79P53_22387025_ChIP-Seq_ESCs_Mouse1.11941910
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11773409
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10904182
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10375492
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.10364835
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.10163413
85RNF2_27304074_Chip-Seq_NSC_Mouse1.06788518
86TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06744022
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.06596878
88CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04986398
89KDM2B_26808549_Chip-Seq_REH_Human1.04724817
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.02596838
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01510519
92EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00471455
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.00061107
94RXR_22108803_ChIP-Seq_LS180_Human0.99895379
95IRF1_19129219_ChIP-ChIP_H3396_Human0.99832263
96SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98784447
97P300_18555785_Chip-Seq_ESCs_Mouse0.98728573
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.98394073
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98394073
100AHR_22903824_ChIP-Seq_MCF-7_Human0.98058463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.61975493
2MP0003195_calcinosis3.10230368
3MP0008057_abnormal_DNA_replication2.94017031
4MP0001501_abnormal_sleep_pattern2.87382608
5MP0001968_abnormal_touch/_nociception2.83898453
6MP0005551_abnormal_eye_electrophysiolog2.76895608
7MP0009046_muscle_twitch2.57029051
8MP0004043_abnormal_pH_regulation2.35384049
9MP0003646_muscle_fatigue2.28044537
10MP0006276_abnormal_autonomic_nervous2.26862236
11MP0002102_abnormal_ear_morphology2.19364501
12MP0005646_abnormal_pituitary_gland2.16636602
13MP0008877_abnormal_DNA_methylation2.16222468
14MP0002736_abnormal_nociception_after2.13279631
15MP0005645_abnormal_hypothalamus_physiol2.10016456
16MP0009745_abnormal_behavioral_response2.05579604
17MP0001984_abnormal_olfaction1.98900691
18MP0003880_abnormal_central_pattern1.98092671
19MP0000372_irregular_coat_pigmentation1.97957802
20MP0000427_abnormal_hair_cycle1.89072253
21MP0001486_abnormal_startle_reflex1.87388223
22MP0005253_abnormal_eye_physiology1.71132583
23MP0002876_abnormal_thyroid_physiology1.69265745
24MP0005670_abnormal_white_adipose1.68391027
25MP0008872_abnormal_physiological_respon1.64546281
26MP0001986_abnormal_taste_sensitivity1.63969246
27MP0003045_fibrosis1.60857204
28MP0002138_abnormal_hepatobiliary_system1.60317749
29MP0002272_abnormal_nervous_system1.59641005
30MP0001485_abnormal_pinna_reflex1.55152170
31MP0002735_abnormal_chemical_nociception1.53999220
32MP0004147_increased_porphyrin_level1.52965863
33MP0002572_abnormal_emotion/affect_behav1.49072438
34MP0005410_abnormal_fertilization1.47573655
35MP0003950_abnormal_plasma_membrane1.46990978
36MP0005174_abnormal_tail_pigmentation1.43565473
37MP0006054_spinal_hemorrhage1.42348667
38MP0002064_seizures1.41248167
39MP0000383_abnormal_hair_follicle1.36551318
40MP0002234_abnormal_pharynx_morphology1.33846697
41MP0001970_abnormal_pain_threshold1.31484500
42MP0000631_abnormal_neuroendocrine_gland1.30352615
43MP0003635_abnormal_synaptic_transmissio1.28773601
44MP0003136_yellow_coat_color1.26307452
45MP0005386_behavior/neurological_phenoty1.26265155
46MP0004924_abnormal_behavior1.26265155
47MP0002733_abnormal_thermal_nociception1.23539006
48MP0003718_maternal_effect1.23454884
49MP0000230_abnormal_systemic_arterial1.21373266
50MP0010386_abnormal_urinary_bladder1.19355938
51MP0005167_abnormal_blood-brain_barrier1.17756353
52MP0002067_abnormal_sensory_capabilities1.16654308
53MP0001764_abnormal_homeostasis1.16574456
54MP0003183_abnormal_peptide_metabolism1.15227200
55MP0002557_abnormal_social/conspecific_i1.14071645
56MP0002638_abnormal_pupillary_reflex1.13464305
57MP0008875_abnormal_xenobiotic_pharmacok1.13408463
58MP0002168_other_aberrant_phenotype1.12332582
59MP0001529_abnormal_vocalization1.11884842
60MP0003252_abnormal_bile_duct1.11126109
61MP0003698_abnormal_male_reproductive1.09493764
62MP0002837_dystrophic_cardiac_calcinosis1.09384749
63MP0005310_abnormal_salivary_gland1.08992861
64MP0003633_abnormal_nervous_system1.07063539
65MP0002063_abnormal_learning/memory/cond1.07045790
66MP0006072_abnormal_retinal_apoptosis1.07018021
67MP0002928_abnormal_bile_duct1.03206767
68MP0004142_abnormal_muscle_tone1.02633681
69MP0002229_neurodegeneration1.00993032
70MP0001664_abnormal_digestion1.00079208
71MP0005395_other_phenotype0.95225268
72MP0004215_abnormal_myocardial_fiber0.94919300
73MP0005171_absent_coat_pigmentation0.92940453
74MP0005084_abnormal_gallbladder_morpholo0.91431788
75MP0001929_abnormal_gametogenesis0.91212476
76MP0004484_altered_response_of0.89979599
77MP0005266_abnormal_metabolism0.87637831
78MP0004742_abnormal_vestibular_system0.87132584
79MP0002734_abnormal_mechanical_nocicepti0.87022995
80MP0004145_abnormal_muscle_electrophysio0.86326741
81MP0002095_abnormal_skin_pigmentation0.85995918
82MP0004085_abnormal_heartbeat0.85977797
83MP0003787_abnormal_imprinting0.83707223
84MP0009697_abnormal_copulation0.82220664
85MP0005647_abnormal_sex_gland0.81661489
86MP0003631_nervous_system_phenotype0.81324421
87MP0005085_abnormal_gallbladder_physiolo0.80999730
88MP0008058_abnormal_DNA_repair0.78240064
89MP0005389_reproductive_system_phenotype0.77692169
90MP0000015_abnormal_ear_pigmentation0.77511448
91MP0006292_abnormal_olfactory_placode0.77429928
92MP0000538_abnormal_urinary_bladder0.77073097
93MP0010678_abnormal_skin_adnexa0.76243948
94MP0001963_abnormal_hearing_physiology0.75497620
95MP0002938_white_spotting0.75200016
96MP0002752_abnormal_somatic_nervous0.73486566
97MP0005195_abnormal_posterior_eye0.73418936
98MP0005075_abnormal_melanosome_morpholog0.73001189
99MP0008775_abnormal_heart_ventricle0.72625012
100MP0004859_abnormal_synaptic_plasticity0.69719660

Predicted human phenotypes

RankGene SetZ-score
1Attenuation of retinal blood vessels (HP:0007843)4.46284260
2Pancreatic cysts (HP:0001737)4.34621329
3Gaze-evoked nystagmus (HP:0000640)4.23826359
4Pancreatic fibrosis (HP:0100732)3.96765067
5Hyperventilation (HP:0002883)3.86564274
6True hermaphroditism (HP:0010459)3.77224684
7Abolished electroretinogram (ERG) (HP:0000550)3.43126838
8Abnormality of midbrain morphology (HP:0002418)3.37203343
9Molar tooth sign on MRI (HP:0002419)3.37203343
10Bony spicule pigmentary retinopathy (HP:0007737)3.27890654
11Medial flaring of the eyebrow (HP:0010747)3.24894664
12Genetic anticipation (HP:0003743)3.23568061
13Congenital stationary night blindness (HP:0007642)3.22250156
14Chronic hepatic failure (HP:0100626)3.19075218
15Progressive cerebellar ataxia (HP:0002073)3.15130807
16Febrile seizures (HP:0002373)3.06135553
17Increased corneal curvature (HP:0100692)3.04388788
18Keratoconus (HP:0000563)3.04388788
19Abnormality of the renal cortex (HP:0011035)3.01787511
20Absent speech (HP:0001344)2.95950917
21Nephronophthisis (HP:0000090)2.92625526
22Decreased central vision (HP:0007663)2.91836009
23Cystic liver disease (HP:0006706)2.87746239
24Congenital sensorineural hearing impairment (HP:0008527)2.82942543
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.82914341
26Abnormality of the renal medulla (HP:0100957)2.76204105
27Type II lissencephaly (HP:0007260)2.72302876
28Focal seizures (HP:0007359)2.70545643
29Gait imbalance (HP:0002141)2.67209328
30Progressive inability to walk (HP:0002505)2.64508702
31Cerebellar dysplasia (HP:0007033)2.63139503
32Congenital primary aphakia (HP:0007707)2.61521035
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.60709680
34Abnormal rod and cone electroretinograms (HP:0008323)2.59123825
35Inability to walk (HP:0002540)2.53451351
36Central scotoma (HP:0000603)2.49713024
37Stomach cancer (HP:0012126)2.45088669
38Protruding tongue (HP:0010808)2.44758676
39Dialeptic seizures (HP:0011146)2.43146231
40Thyroid-stimulating hormone excess (HP:0002925)2.40514343
41Clumsiness (HP:0002312)2.39924285
42Nephrogenic diabetes insipidus (HP:0009806)2.37440909
43Genital tract atresia (HP:0001827)2.36197538
44Fair hair (HP:0002286)2.35710890
45Broad-based gait (HP:0002136)2.34766267
46Hypothermia (HP:0002045)2.33531257
47Renal cortical cysts (HP:0000803)2.32880206
48Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31946844
49Focal motor seizures (HP:0011153)2.31777422
50Intestinal atresia (HP:0011100)2.29175283
51Pendular nystagmus (HP:0012043)2.28234993
52Aplasia/Hypoplasia of the tongue (HP:0010295)2.27882182
53Abnormal drinking behavior (HP:0030082)2.27200350
54Polydipsia (HP:0001959)2.27200350
55Facial diplegia (HP:0001349)2.25345540
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23917965
57Abnormality of alanine metabolism (HP:0010916)2.23917965
58Hyperalaninemia (HP:0003348)2.23917965
59Congenital hepatic fibrosis (HP:0002612)2.21003987
60Vaginal atresia (HP:0000148)2.19706836
61Constricted visual fields (HP:0001133)2.17275493
62Lissencephaly (HP:0001339)2.15154911
63Absent/shortened dynein arms (HP:0200106)2.11053346
64Dynein arm defect of respiratory motile cilia (HP:0012255)2.11053346
65Abnormal ciliary motility (HP:0012262)2.10961818
66Abnormality of macular pigmentation (HP:0008002)2.09115087
67Hemiparesis (HP:0001269)2.06443194
68Tubulointerstitial nephritis (HP:0001970)2.06395495
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.03719566
70Widely spaced teeth (HP:0000687)2.02920795
71Ketoacidosis (HP:0001993)2.02867788
72Poor coordination (HP:0002370)2.02596540
73Atonic seizures (HP:0010819)2.02373448
74Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01898395
75Postaxial foot polydactyly (HP:0001830)2.01537302
76Sclerocornea (HP:0000647)1.99139380
77Absence seizures (HP:0002121)1.97798980
78Chorioretinal atrophy (HP:0000533)1.97228634
79Furrowed tongue (HP:0000221)1.96756175
80Decreased circulating renin level (HP:0003351)1.94641945
81Small hand (HP:0200055)1.93113509
82Retinitis pigmentosa (HP:0000510)1.92949232
83Macular degeneration (HP:0000608)1.91056063
84Astigmatism (HP:0000483)1.89750100
85Thyroiditis (HP:0100646)1.89489218
86Tubular atrophy (HP:0000092)1.88143869
87Aplasia/Hypoplasia of the uvula (HP:0010293)1.86486580
88Abnormality of B cell number (HP:0010975)1.85740637
89Ketosis (HP:0001946)1.85180438
90Generalized hypopigmentation of hair (HP:0011358)1.84805784
91Polyuria (HP:0000103)1.83206519
92Anencephaly (HP:0002323)1.79880257
93Sloping forehead (HP:0000340)1.77412143
94Short foot (HP:0001773)1.74732885
95Bile duct proliferation (HP:0001408)1.74591732
96Abnormal biliary tract physiology (HP:0012439)1.74591732
97Retinal dysplasia (HP:0007973)1.72012345
98Preaxial foot polydactyly (HP:0001841)1.71765488
99Large for gestational age (HP:0001520)1.71338149
100Abnormal glycosylation (HP:0012345)1.70771452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.28499339
2ADRBK22.84873640
3BMPR1B2.71188836
4PINK12.36135769
5MAP4K22.35469849
6NUAK12.32289310
7TAOK32.18919227
8WNK32.14272515
9ACVR1B2.11840273
10INSRR1.93152798
11MAPK131.87617522
12CASK1.77944967
13STK391.74694655
14GRK11.72582893
15ZAK1.66605251
16PIK3CG1.54616105
17LATS11.42880621
18OXSR11.42719837
19MAP3K41.41982696
20NTRK31.37597428
21STK38L1.34479018
22EIF2AK31.33093973
23TRIM281.25445079
24BCR1.16361180
25TNIK1.16095952
26ADRBK11.15487786
27DAPK21.13873980
28TEC1.12313764
29TXK1.10443448
30MKNK21.08226184
31BCKDK1.01707772
32PTK2B0.99928503
33EPHA40.99502171
34PRKCE0.99326086
35AKT30.99034889
36WNK40.97467405
37PLK20.93397957
38TNK20.92521223
39FER0.90357908
40KIT0.88083578
41FLT30.86802636
42PRKCG0.83062828
43ERBB30.81295838
44TGFBR10.77165520
45MARK10.77016073
46FGFR20.75179055
47CSNK1A1L0.74332002
48STK30.68737846
49MAP2K70.67464333
50CAMK2A0.66612742
51PIK3CA0.65890319
52MKNK10.65611026
53PAK30.64608422
54TLK10.62384334
55CSNK1G10.62120558
56CSNK1G20.61634974
57CCNB10.60962216
58MAPKAPK50.60156248
59OBSCN0.57485916
60MUSK0.56889059
61STK380.56768410
62CSNK1G30.56534721
63MAPKAPK30.54805158
64ITK0.54367953
65IRAK10.52016874
66NLK0.51783851
67PRKAA20.51344850
68MAP3K70.49903751
69PLK40.46749268
70TRPM70.46458148
71NTRK20.45558120
72SGK20.42557954
73CAMK10.42279219
74DYRK1A0.41732832
75CAMK1G0.41526804
76PRKCQ0.41279527
77CAMK40.41250774
78CSNK1D0.39665059
79PKN10.37383599
80IKBKB0.36614649
81TIE10.36361982
82BRSK20.36326422
83MARK30.34667901
84ATM0.33888884
85PRKACB0.33302690
86MELK0.33118677
87SYK0.33106317
88ABL10.32963109
89PRKACA0.32713751
90PRKAA10.32630635
91MAP2K60.31003962
92GRK50.30918657
93CAMKK20.30213611
94PDK20.30128864
95PRKCB0.29835970
96CSNK1A10.28930183
97PRKCA0.28356252
98PRKD30.28032224
99PRKG10.27127275
100SIK20.26655621

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.02592017
2Butanoate metabolism_Homo sapiens_hsa006502.98133063
3Nicotine addiction_Homo sapiens_hsa050332.49027799
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.45588934
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.38915353
6ABC transporters_Homo sapiens_hsa020102.28494010
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23246302
8Linoleic acid metabolism_Homo sapiens_hsa005912.20865674
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.14712194
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.14303731
11Tryptophan metabolism_Homo sapiens_hsa003802.08428580
12Nitrogen metabolism_Homo sapiens_hsa009102.06901360
13Taste transduction_Homo sapiens_hsa047422.01654917
14Olfactory transduction_Homo sapiens_hsa047401.88628509
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86613018
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85788389
17Morphine addiction_Homo sapiens_hsa050321.83363441
18Propanoate metabolism_Homo sapiens_hsa006401.74333040
19Homologous recombination_Homo sapiens_hsa034401.73183143
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71899720
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.71471994
22Ether lipid metabolism_Homo sapiens_hsa005651.70408879
23Circadian entrainment_Homo sapiens_hsa047131.62712070
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.61847941
25Fanconi anemia pathway_Homo sapiens_hsa034601.60142329
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53931135
27Salivary secretion_Homo sapiens_hsa049701.50783003
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47231122
29GABAergic synapse_Homo sapiens_hsa047271.43456212
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43339356
31Glutamatergic synapse_Homo sapiens_hsa047241.42523487
32Selenocompound metabolism_Homo sapiens_hsa004501.33669968
33Calcium signaling pathway_Homo sapiens_hsa040201.29136634
34Serotonergic synapse_Homo sapiens_hsa047261.29110832
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25475586
36Retinol metabolism_Homo sapiens_hsa008301.21564969
37Chemical carcinogenesis_Homo sapiens_hsa052041.20695776
38Ovarian steroidogenesis_Homo sapiens_hsa049131.19237218
39Glycerolipid metabolism_Homo sapiens_hsa005611.15027788
40Non-homologous end-joining_Homo sapiens_hsa034501.14582256
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11041226
42Basal transcription factors_Homo sapiens_hsa030221.10069852
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08588379
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.07833877
45beta-Alanine metabolism_Homo sapiens_hsa004101.06496393
46Arachidonic acid metabolism_Homo sapiens_hsa005901.03605570
47Histidine metabolism_Homo sapiens_hsa003401.01298536
48Peroxisome_Homo sapiens_hsa041461.00976673
49Insulin secretion_Homo sapiens_hsa049110.99642268
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97125952
51Lysine degradation_Homo sapiens_hsa003100.97002523
52Dorso-ventral axis formation_Homo sapiens_hsa043200.94694925
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94517069
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.93423165
55Sphingolipid metabolism_Homo sapiens_hsa006000.90008254
56Regulation of autophagy_Homo sapiens_hsa041400.88909821
57Renin secretion_Homo sapiens_hsa049240.88527500
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85159934
59Long-term depression_Homo sapiens_hsa047300.83232068
60Caffeine metabolism_Homo sapiens_hsa002320.80392446
61Fatty acid degradation_Homo sapiens_hsa000710.77417829
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73706984
63Circadian rhythm_Homo sapiens_hsa047100.72843945
64Dopaminergic synapse_Homo sapiens_hsa047280.72308043
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.72274467
66Oxytocin signaling pathway_Homo sapiens_hsa049210.71016125
67One carbon pool by folate_Homo sapiens_hsa006700.68068212
68Gastric acid secretion_Homo sapiens_hsa049710.67495961
69RNA polymerase_Homo sapiens_hsa030200.67219562
70Fatty acid biosynthesis_Homo sapiens_hsa000610.67002741
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63559197
72Cholinergic synapse_Homo sapiens_hsa047250.62564618
73cAMP signaling pathway_Homo sapiens_hsa040240.62108194
74Purine metabolism_Homo sapiens_hsa002300.62052007
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.60455448
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54042667
77Fatty acid metabolism_Homo sapiens_hsa012120.52839133
78Amphetamine addiction_Homo sapiens_hsa050310.51138505
79Pancreatic secretion_Homo sapiens_hsa049720.50930059
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47898175
81RNA degradation_Homo sapiens_hsa030180.47439582
82Platelet activation_Homo sapiens_hsa046110.45566525
83Fat digestion and absorption_Homo sapiens_hsa049750.44793507
84Asthma_Homo sapiens_hsa053100.43725411
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41449471
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41326896
87Metabolic pathways_Homo sapiens_hsa011000.40430551
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38000864
89Cocaine addiction_Homo sapiens_hsa050300.37243222
90N-Glycan biosynthesis_Homo sapiens_hsa005100.33964339
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32850213
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29172236
93Primary immunodeficiency_Homo sapiens_hsa053400.28661032
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28456666
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28159228
96Graft-versus-host disease_Homo sapiens_hsa053320.24865757
97Type I diabetes mellitus_Homo sapiens_hsa049400.24213643
98Protein export_Homo sapiens_hsa030600.23212237
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.22320489
100Ras signaling pathway_Homo sapiens_hsa040140.17790060

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