

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative thymic T cell selection (GO:0045060) | 6.80010677 |
| 2 | negative T cell selection (GO:0043383) | 6.78867355 |
| 3 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 6.77938745 |
| 4 | positive regulation of gamma-delta T cell activation (GO:0046645) | 6.76530387 |
| 5 | regulation of isotype switching to IgG isotypes (GO:0048302) | 6.23345734 |
| 6 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 6.09000208 |
| 7 | negative regulation of cell killing (GO:0031342) | 6.09000208 |
| 8 | leukocyte aggregation (GO:0070486) | 6.04927878 |
| 9 | cellular response to interleukin-15 (GO:0071350) | 5.89156363 |
| 10 | thymic T cell selection (GO:0045061) | 5.53791256 |
| 11 | T cell migration (GO:0072678) | 5.52240168 |
| 12 | positive thymic T cell selection (GO:0045059) | 5.51346051 |
| 13 | cytidine metabolic process (GO:0046087) | 5.50882157 |
| 14 | cytidine catabolic process (GO:0006216) | 5.50882157 |
| 15 | cytidine deamination (GO:0009972) | 5.50882157 |
| 16 | regulation of T cell tolerance induction (GO:0002664) | 5.48594339 |
| 17 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 5.36790912 |
| 18 | response to interleukin-15 (GO:0070672) | 5.21059447 |
| 19 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 5.17071917 |
| 20 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.17071917 |
| 21 | T cell selection (GO:0045058) | 5.16220610 |
| 22 | regulation of B cell receptor signaling pathway (GO:0050855) | 5.12985439 |
| 23 | positive T cell selection (GO:0043368) | 5.04760274 |
| 24 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.99418768 |
| 25 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.98370259 |
| 26 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 4.91839997 |
| 27 | T cell receptor signaling pathway (GO:0050852) | 4.88559947 |
| 28 | interferon-gamma production (GO:0032609) | 4.85215942 |
| 29 | sequestering of actin monomers (GO:0042989) | 4.79537594 |
| 30 | regulation of T cell receptor signaling pathway (GO:0050856) | 4.74870050 |
| 31 | immunoglobulin mediated immune response (GO:0016064) | 4.72767847 |
| 32 | regulation of alpha-beta T cell proliferation (GO:0046640) | 4.72535847 |
| 33 | T cell costimulation (GO:0031295) | 4.67277360 |
| 34 | lymphocyte costimulation (GO:0031294) | 4.66801158 |
| 35 | regulation of gamma-delta T cell activation (GO:0046643) | 4.65495779 |
| 36 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.59706909 |
| 37 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.57461722 |
| 38 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 4.49809789 |
| 39 | DNA deamination (GO:0045006) | 4.35612178 |
| 40 | mast cell activation (GO:0045576) | 4.33773378 |
| 41 | positive regulation of tolerance induction (GO:0002645) | 4.31670810 |
| 42 | antigen receptor-mediated signaling pathway (GO:0050851) | 4.31652207 |
| 43 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.23611112 |
| 44 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 4.21204779 |
| 45 | negative regulation of interleukin-12 production (GO:0032695) | 4.16338747 |
| 46 | ribosomal small subunit assembly (GO:0000028) | 4.09194317 |
| 47 | neutrophil activation involved in immune response (GO:0002283) | 3.99796599 |
| 48 | regulation of tolerance induction (GO:0002643) | 3.98766104 |
| 49 | regulation of isotype switching (GO:0045191) | 3.95750740 |
| 50 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.86311426 |
| 51 | tolerance induction (GO:0002507) | 3.85726161 |
| 52 | B cell mediated immunity (GO:0019724) | 3.82210946 |
| 53 | negative regulation of type 2 immune response (GO:0002829) | 3.80959199 |
| 54 | granulocyte activation (GO:0036230) | 3.80924286 |
| 55 | regulation of immunoglobulin mediated immune response (GO:0002889) | 3.69269959 |
| 56 | regulation of lymphocyte chemotaxis (GO:1901623) | 3.68834862 |
| 57 | positive regulation of B cell differentiation (GO:0045579) | 3.63659280 |
| 58 | regulation of B cell mediated immunity (GO:0002712) | 3.61409383 |
| 59 | positive regulation of interleukin-2 production (GO:0032743) | 3.59504730 |
| 60 | regulation of regulatory T cell differentiation (GO:0045589) | 3.58849148 |
| 61 | positive regulation of lymphocyte migration (GO:2000403) | 3.58385789 |
| 62 | positive regulation of calcium-mediated signaling (GO:0050850) | 3.55901208 |
| 63 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 3.53955869 |
| 64 | positive regulation of interleukin-8 secretion (GO:2000484) | 3.52751747 |
| 65 | natural killer cell activation (GO:0030101) | 3.52387334 |
| 66 | positive regulation of isotype switching (GO:0045830) | 3.49868006 |
| 67 | cellular response to interferon-beta (GO:0035458) | 3.45739510 |
| 68 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.45560794 |
| 69 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.45450535 |
| 70 | positive regulation of monocyte chemotaxis (GO:0090026) | 3.44904820 |
| 71 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 3.43166849 |
| 72 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.43166849 |
| 73 | lymphocyte chemotaxis (GO:0048247) | 3.42403561 |
| 74 | neutrophil activation (GO:0042119) | 3.39140393 |
| 75 | macrophage activation involved in immune response (GO:0002281) | 3.38830987 |
| 76 | NIK/NF-kappaB signaling (GO:0038061) | 3.37805039 |
| 77 | regulation of immunoglobulin production (GO:0002637) | 3.36954739 |
| 78 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.34354029 |
| 79 | B cell receptor signaling pathway (GO:0050853) | 3.31886072 |
| 80 | negative regulation of T cell mediated immunity (GO:0002710) | 3.31516114 |
| 81 | response to peptidoglycan (GO:0032494) | 3.31412349 |
| 82 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.30950763 |
| 83 | positive regulation of B cell mediated immunity (GO:0002714) | 3.30950763 |
| 84 | regulation of antigen processing and presentation (GO:0002577) | 3.30926291 |
| 85 | negative regulation of viral genome replication (GO:0045071) | 3.30291658 |
| 86 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.30216781 |
| 87 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.30216781 |
| 88 | lymphocyte migration (GO:0072676) | 3.28167339 |
| 89 | eosinophil chemotaxis (GO:0048245) | 3.27794682 |
| 90 | regulation of response to interferon-gamma (GO:0060330) | 3.27585950 |
| 91 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.25833695 |
| 92 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.25833695 |
| 93 | modulation by symbiont of host immune response (GO:0052553) | 3.25833695 |
| 94 | positive regulation by symbiont of host defense response (GO:0052509) | 3.25833695 |
| 95 | modulation by symbiont of host defense response (GO:0052031) | 3.25833695 |
| 96 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.25833695 |
| 97 | regulation of lymphocyte migration (GO:2000401) | 3.24083545 |
| 98 | T cell differentiation (GO:0030217) | 3.22688304 |
| 99 | positive regulation of DNA recombination (GO:0045911) | 3.22516523 |
| 100 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 3.22213551 |
| 101 | positive regulation of antigen processing and presentation (GO:0002579) | 3.22159947 |
| 102 | positive regulation of interferon-gamma production (GO:0032729) | 3.21966356 |
| 103 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.21944723 |
| 104 | T cell activation (GO:0042110) | 3.19727440 |
| 105 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 3.18899126 |
| 106 | regulation of chronic inflammatory response (GO:0002676) | 3.17534935 |
| 107 | positive regulation of T-helper 1 type immune response (GO:0002827) | 3.17426226 |
| 108 | myeloid cell activation involved in immune response (GO:0002275) | 3.17323686 |
| 109 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.16515673 |
| 110 | leukocyte cell-cell adhesion (GO:0007159) | 3.16264562 |
| 111 | type I interferon signaling pathway (GO:0060337) | 3.16119231 |
| 112 | cellular response to type I interferon (GO:0071357) | 3.16119231 |
| 113 | response to type I interferon (GO:0034340) | 3.15654442 |
| 114 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 3.15575396 |
| 115 | mast cell degranulation (GO:0043303) | 3.13785332 |
| 116 | mast cell activation involved in immune response (GO:0002279) | 3.13785332 |
| 117 | monocyte chemotaxis (GO:0002548) | 3.13298260 |
| 118 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.12854642 |
| 119 | regulation of B cell differentiation (GO:0045577) | 3.12728206 |
| 120 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.12410774 |
| 121 | negative regulation of cytokine production involved in immune response (GO:0002719) | 3.12255537 |
| 122 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.12018050 |
| 123 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.11579683 |
| 124 | detection of bacterium (GO:0016045) | 3.10843076 |
| 125 | cellular response to zinc ion (GO:0071294) | 3.10634759 |
| 126 | alpha-beta T cell differentiation (GO:0046632) | 3.10633551 |
| 127 | respiratory burst (GO:0045730) | 3.09432063 |
| 128 | activated T cell proliferation (GO:0050798) | 3.08826098 |
| 129 | detection of other organism (GO:0098543) | 3.08115027 |
| 130 | negative regulation of immunoglobulin mediated immune response (GO:0002890) | 3.07423615 |
| 131 | negative regulation of B cell mediated immunity (GO:0002713) | 3.07423615 |
| 132 | alpha-beta T cell activation (GO:0046631) | 3.07341100 |
| 133 | heterotypic cell-cell adhesion (GO:0034113) | 3.04814492 |
| 134 | positive regulation of immunoglobulin production (GO:0002639) | 3.04237582 |
| 135 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.03720988 |
| 136 | regulation of respiratory burst (GO:0060263) | 3.03404521 |
| 137 | positive regulation of defense response to virus by host (GO:0002230) | 3.02925237 |
| 138 | regulation of mononuclear cell migration (GO:0071675) | 3.02649907 |
| 139 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 2.99000613 |
| 140 | T-helper cell differentiation (GO:0042093) | 2.99000613 |
| 141 | myeloid dendritic cell activation (GO:0001773) | 2.98958217 |
| 142 | T cell homeostasis (GO:0043029) | 2.97663806 |
| 143 | response to protozoan (GO:0001562) | 2.95759050 |
| 144 | positive regulation of granulocyte differentiation (GO:0030854) | 2.95189327 |
| 145 | eosinophil migration (GO:0072677) | 2.94424505 |
| 146 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.93847057 |
| 147 | defense response to protozoan (GO:0042832) | 2.93833589 |
| 148 | cellular response to interferon-gamma (GO:0071346) | 2.93333618 |
| 149 | myeloid dendritic cell differentiation (GO:0043011) | 2.93227414 |
| 150 | regulation of cell killing (GO:0031341) | 2.93201822 |
| 151 | regulation of activation of Janus kinase activity (GO:0010533) | 2.93055639 |
| 152 | regulation of defense response to virus by virus (GO:0050690) | 2.91984768 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 6.49958650 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 5.76309985 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.03923245 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.77110416 |
| 5 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.93366480 |
| 6 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.84110235 |
| 7 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.70252969 |
| 8 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.65119781 |
| 9 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.37181766 |
| 10 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.32339492 |
| 11 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 3.25987141 |
| 12 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.25215143 |
| 13 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 3.08838709 |
| 14 | MYB_26560356_Chip-Seq_TH2_Human | 3.05660200 |
| 15 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.95974483 |
| 16 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.66831356 |
| 17 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.65607486 |
| 18 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.60194766 |
| 19 | MAF_26560356_Chip-Seq_TH1_Human | 2.59175391 |
| 20 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.58825491 |
| 21 | MYB_26560356_Chip-Seq_TH1_Human | 2.33696479 |
| 22 | * SPI1_23547873_ChIP-Seq_NB4_Human | 2.32947977 |
| 23 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.31229620 |
| 24 | UTX_26944678_Chip-Seq_JUKART_Human | 2.18642927 |
| 25 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.17818901 |
| 26 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.11515018 |
| 27 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.09206033 |
| 28 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.08834700 |
| 29 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.07303173 |
| 30 | MYC_22102868_ChIP-Seq_BL_Human | 2.06920431 |
| 31 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 2.04845608 |
| 32 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.98557618 |
| 33 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.98511881 |
| 34 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.94333795 |
| 35 | MAF_26560356_Chip-Seq_TH2_Human | 1.87605148 |
| 36 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.81260184 |
| 37 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.71455885 |
| 38 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.71409258 |
| 39 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.68128525 |
| 40 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.67757592 |
| 41 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.66405129 |
| 42 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.64939418 |
| 43 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.64166127 |
| 44 | GATA1_22025678_ChIP-Seq_K562_Human | 1.57010911 |
| 45 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.55703422 |
| 46 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.55257523 |
| 47 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.51161991 |
| 48 | SPI1_23127762_ChIP-Seq_K562_Human | 1.50180399 |
| 49 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.48728538 |
| 50 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.44954467 |
| 51 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.44134389 |
| 52 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.42670703 |
| 53 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.42244984 |
| 54 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.41528085 |
| 55 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.33379460 |
| 56 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.32207090 |
| 57 | GATA3_26560356_Chip-Seq_TH2_Human | 1.30328507 |
| 58 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.29263704 |
| 59 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.29011817 |
| 60 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.26134379 |
| 61 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.25324302 |
| 62 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.22698313 |
| 63 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.21436038 |
| 64 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.18950212 |
| 65 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.18027629 |
| 66 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.17536782 |
| 67 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.16196141 |
| 68 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.15610516 |
| 69 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.12950335 |
| 70 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.12007471 |
| 71 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.09962332 |
| 72 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.09623588 |
| 73 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.09593054 |
| 74 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.09024394 |
| 75 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.06949752 |
| 76 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.06932987 |
| 77 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.06737810 |
| 78 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.06532713 |
| 79 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.05363927 |
| 80 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.04036551 |
| 81 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.02169498 |
| 82 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.01721912 |
| 83 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.01461021 |
| 84 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.00615377 |
| 85 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.00495329 |
| 86 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.00303055 |
| 87 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.98759882 |
| 88 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.97976781 |
| 89 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.96705456 |
| 90 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.96012505 |
| 91 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.95531948 |
| 92 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.94775664 |
| 93 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.94144220 |
| 94 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.93125521 |
| 95 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.92799384 |
| 96 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 0.92666371 |
| 97 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.91907340 |
| 98 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.91650782 |
| 99 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.90748095 |
| 100 | P300_27268052_Chip-Seq_Bcells_Human | 0.90517994 |
| 101 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.89796628 |
| 102 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.89328390 |
| 103 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.88876411 |
| 104 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.87212980 |
| 105 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.86991459 |
| 106 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.86909811 |
| 107 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.86795101 |
| 108 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.86548744 |
| 109 | SA1_27219007_Chip-Seq_Bcells_Human | 0.86452550 |
| 110 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.85881143 |
| 111 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.85699004 |
| 112 | SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human | 0.84184129 |
| 113 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.81599919 |
| 114 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.81403936 |
| 115 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.81163294 |
| 116 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.80865422 |
| 117 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.80278089 |
| 118 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.79963498 |
| 119 | P68_20966046_ChIP-Seq_HELA_Human | 0.79268368 |
| 120 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.78760973 |
| 121 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.77039488 |
| 122 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 0.73874532 |
| 123 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.72113831 |
| 124 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.70270313 |
| 125 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.68887477 |
| 126 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.68755242 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003763_abnormal_thymus_physiology | 5.23972751 |
| 2 | MP0005671_abnormal_response_to | 5.05073062 |
| 3 | MP0001835_abnormal_antigen_presentation | 4.08321556 |
| 4 | MP0000685_abnormal_immune_system | 3.59061542 |
| 5 | MP0009785_altered_susceptibility_to | 3.29885051 |
| 6 | MP0001800_abnormal_humoral_immune | 3.15330951 |
| 7 | MP0005000_abnormal_immune_tolerance | 3.13375058 |
| 8 | MP0001790_abnormal_immune_system | 3.11627625 |
| 9 | MP0005387_immune_system_phenotype | 3.11627625 |
| 10 | MP0002420_abnormal_adaptive_immunity | 3.05264121 |
| 11 | MP0001819_abnormal_immune_cell | 3.03212834 |
| 12 | MP0002723_abnormal_immune_serum | 2.94630917 |
| 13 | MP0005025_abnormal_response_to | 2.89594816 |
| 14 | MP0003724_increased_susceptibility_to | 2.82052324 |
| 15 | MP0002452_abnormal_antigen_presenting | 2.76549997 |
| 16 | MP0002148_abnormal_hypersensitivity_rea | 2.76509996 |
| 17 | MP0009333_abnormal_splenocyte_physiolog | 2.74389943 |
| 18 | MP0002398_abnormal_bone_marrow | 2.72697761 |
| 19 | MP0000716_abnormal_immune_system | 2.43458943 |
| 20 | MP0006082_CNS_inflammation | 2.39197260 |
| 21 | MP0003436_decreased_susceptibility_to | 2.36890085 |
| 22 | MP0002405_respiratory_system_inflammati | 2.36122359 |
| 23 | MP0002419_abnormal_innate_immunity | 2.34778857 |
| 24 | MP0000703_abnormal_thymus_morphology | 2.23421285 |
| 25 | MP0002166_altered_tumor_susceptibility | 2.20236259 |
| 26 | MP0002722_abnormal_immune_system | 2.15110112 |
| 27 | MP0000689_abnormal_spleen_morphology | 2.07795463 |
| 28 | MP0003866_abnormal_defecation | 2.01110935 |
| 29 | MP0010155_abnormal_intestine_physiology | 2.01046522 |
| 30 | MP0001873_stomach_inflammation | 2.00232851 |
| 31 | MP0002429_abnormal_blood_cell | 1.98538985 |
| 32 | MP0002933_joint_inflammation | 1.92326209 |
| 33 | MP0003806_abnormal_nucleotide_metabolis | 1.88141755 |
| 34 | MP0002006_tumorigenesis | 1.78803969 |
| 35 | MP0005464_abnormal_platelet_physiology | 1.76559742 |
| 36 | MP0002396_abnormal_hematopoietic_system | 1.74523585 |
| 37 | MP0004510_myositis | 1.71936255 |
| 38 | MP0004381_abnormal_hair_follicle | 1.70771123 |
| 39 | MP0001845_abnormal_inflammatory_respons | 1.62723107 |
| 40 | MP0003075_altered_response_to | 1.59475576 |
| 41 | MP0005310_abnormal_salivary_gland | 1.53443069 |
| 42 | MP0005075_abnormal_melanosome_morpholog | 1.52389394 |
| 43 | MP0000465_gastrointestinal_hemorrhage | 1.52005419 |
| 44 | MP0001853_heart_inflammation | 1.48008616 |
| 45 | MP0005174_abnormal_tail_pigmentation | 1.45812512 |
| 46 | MP0000858_altered_metastatic_potential | 1.39103132 |
| 47 | MP0004947_skin_inflammation | 1.34858708 |
| 48 | MP0003693_abnormal_embryo_hatching | 1.32698229 |
| 49 | MP0008469_abnormal_protein_level | 1.32422948 |
| 50 | MP0008057_abnormal_DNA_replication | 1.30294061 |
| 51 | MP0001348_abnormal_lacrimal_gland | 1.23549008 |
| 52 | MP0006292_abnormal_olfactory_placode | 1.21096462 |
| 53 | MP0000604_amyloidosis | 1.20798051 |
| 54 | MP0005166_decreased_susceptibility_to | 1.19272714 |
| 55 | MP0002132_abnormal_respiratory_system | 1.13956743 |
| 56 | MP0009278_abnormal_bone_marrow | 1.09645072 |
| 57 | MP0000015_abnormal_ear_pigmentation | 1.05099993 |
| 58 | MP0001986_abnormal_taste_sensitivity | 1.03324446 |
| 59 | MP0003191_abnormal_cellular_cholesterol | 1.02858171 |
| 60 | MP0009840_abnormal_foam_cell | 1.02836008 |
| 61 | MP0004808_abnormal_hematopoietic_stem | 1.02389646 |
| 62 | MP0003448_altered_tumor_morphology | 1.00376453 |
| 63 | MP0003183_abnormal_peptide_metabolism | 0.98134953 |
| 64 | MP0001533_abnormal_skeleton_physiology | 0.89136841 |
| 65 | MP0002138_abnormal_hepatobiliary_system | 0.88742843 |
| 66 | MP0003303_peritoneal_inflammation | 0.87508326 |
| 67 | MP0008260_abnormal_autophagy | 0.87127603 |
| 68 | MP0003045_fibrosis | 0.86624505 |
| 69 | MP0002095_abnormal_skin_pigmentation | 0.86623212 |
| 70 | MP0001663_abnormal_digestive_system | 0.85532357 |
| 71 | MP0000490_abnormal_crypts_of | 0.81315634 |
| 72 | MP0001851_eye_inflammation | 0.81039837 |
| 73 | MP0002139_abnormal_hepatobiliary_system | 0.78717878 |
| 74 | MP0009763_increased_sensitivity_to | 0.78300816 |
| 75 | MP0002019_abnormal_tumor_incidence | 0.75585595 |
| 76 | MP0003690_abnormal_glial_cell | 0.75477755 |
| 77 | MP0009764_decreased_sensitivity_to | 0.74716812 |
| 78 | MP0005397_hematopoietic_system_phenotyp | 0.74071443 |
| 79 | MP0001545_abnormal_hematopoietic_system | 0.74071443 |
| 80 | MP0009379_abnormal_foot_pigmentation | 0.71543663 |
| 81 | MP0005390_skeleton_phenotype | 0.70864510 |
| 82 | MP0002998_abnormal_bone_remodeling | 0.68191434 |
| 83 | MP0003656_abnormal_erythrocyte_physiolo | 0.67632968 |
| 84 | MP0003828_pulmonary_edema | 0.67323601 |
| 85 | MP0002254_reproductive_system_inflammat | 0.66616678 |
| 86 | MP0005423_abnormal_somatic_nervous | 0.66536589 |
| 87 | MP0005451_abnormal_body_composition | 0.66092380 |
| 88 | MP0008004_abnormal_stomach_pH | 0.65825055 |
| 89 | MP0000343_altered_response_to | 0.65797585 |
| 90 | MP0002277_abnormal_respiratory_mucosa | 0.65012067 |
| 91 | MP0009765_abnormal_xenobiotic_induced | 0.64798520 |
| 92 | MP0001542_abnormal_bone_strength | 0.63843171 |
| 93 | MP0008961_abnormal_basal_metabolism | 0.63526666 |
| 94 | MP0003300_gastrointestinal_ulcer | 0.62949670 |
| 95 | MP0000372_irregular_coat_pigmentation | 0.62346650 |
| 96 | MP0008873_increased_physiological_sensi | 0.62168159 |
| 97 | MP0005165_increased_susceptibility_to | 0.61734663 |
| 98 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.58302303 |
| 99 | MP0000920_abnormal_myelination | 0.57860971 |
| 100 | MP0004883_abnormal_blood_vessel | 0.57596463 |
| 101 | MP0005167_abnormal_blood-brain_barrier | 0.57555711 |
| 102 | MP0010307_abnormal_tumor_latency | 0.57105636 |
| 103 | MP0003795_abnormal_bone_structure | 0.57010885 |
| 104 | MP0005319_abnormal_enzyme/_coenzyme | 0.55923922 |
| 105 | MP0004147_increased_porphyrin_level | 0.55779445 |
| 106 | MP0000249_abnormal_blood_vessel | 0.55239904 |
| 107 | MP0008569_lethality_at_weaning | 0.54785767 |
| 108 | MP0002735_abnormal_chemical_nociception | 0.53974527 |
| 109 | MP0005058_abnormal_lysosome_morphology | 0.52959245 |
| 110 | MP0005084_abnormal_gallbladder_morpholo | 0.52547300 |
| 111 | MP0002163_abnormal_gland_morphology | 0.51870688 |
| 112 | MP0002876_abnormal_thyroid_physiology | 0.51778611 |
| 113 | MP0008874_decreased_physiological_sensi | 0.51420990 |
| 114 | MP0005164_abnormal_response_to | 0.50409634 |
| 115 | MP0000371_diluted_coat_color | 0.49270245 |
| 116 | MP0003172_abnormal_lysosome_physiology | 0.48412649 |
| 117 | MP0005409_darkened_coat_color | 0.47071548 |
| 118 | MP0002136_abnormal_kidney_physiology | 0.47013275 |
| 119 | MP0008872_abnormal_physiological_respon | 0.42324262 |
| 120 | MP0000313_abnormal_cell_death | 0.40487265 |
| 121 | MP0003136_yellow_coat_color | 0.40145639 |
| 122 | MP0002928_abnormal_bile_duct | 0.38304946 |
| 123 | MP0002083_premature_death | 0.38182164 |
| 124 | MP0002693_abnormal_pancreas_physiology | 0.37812377 |
| 125 | MP0005670_abnormal_white_adipose | 0.37797210 |
| 126 | MP0001191_abnormal_skin_condition | 0.37747792 |
| 127 | MP0001905_abnormal_dopamine_level | 0.37553137 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | T lymphocytopenia (HP:0005403) | 5.92221869 |
| 2 | Abnormality of T cell number (HP:0011839) | 5.83284378 |
| 3 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.80432086 |
| 4 | Severe combined immunodeficiency (HP:0004430) | 5.10076287 |
| 5 | IgM deficiency (HP:0002850) | 5.04941945 |
| 6 | Abnormality of glycolipid metabolism (HP:0010969) | 4.88960847 |
| 7 | Abnormality of liposaccharide metabolism (HP:0010968) | 4.88960847 |
| 8 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 4.88960847 |
| 9 | Abnormality of T cells (HP:0002843) | 4.81682182 |
| 10 | Combined immunodeficiency (HP:0005387) | 4.73599954 |
| 11 | Increased IgM level (HP:0003496) | 4.50910844 |
| 12 | Stomatitis (HP:0010280) | 4.43516714 |
| 13 | Eczematoid dermatitis (HP:0000976) | 4.40868355 |
| 14 | Recurrent fungal infections (HP:0002841) | 4.23588940 |
| 15 | Recurrent bronchitis (HP:0002837) | 4.21868415 |
| 16 | Chronic mucocutaneous candidiasis (HP:0002728) | 4.19855012 |
| 17 | Recurrent cutaneous fungal infections (HP:0011370) | 4.19855012 |
| 18 | IgG deficiency (HP:0004315) | 4.14332851 |
| 19 | Autoimmune hemolytic anemia (HP:0001890) | 4.04974990 |
| 20 | Recurrent abscess formation (HP:0002722) | 4.02561424 |
| 21 | Lymphopenia (HP:0001888) | 3.85593918 |
| 22 | Reduced antithrombin III activity (HP:0001976) | 3.84697193 |
| 23 | Abnormality of eosinophils (HP:0001879) | 3.70866722 |
| 24 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.70222423 |
| 25 | Chronic diarrhea (HP:0002028) | 3.66453825 |
| 26 | Chronic otitis media (HP:0000389) | 3.64129465 |
| 27 | Recurrent viral infections (HP:0004429) | 3.59161462 |
| 28 | Increased cerebral lipofuscin (HP:0011813) | 3.48722936 |
| 29 | Myositis (HP:0100614) | 3.46626168 |
| 30 | Hypoproteinemia (HP:0003075) | 3.40274924 |
| 31 | Thyroiditis (HP:0100646) | 3.36888394 |
| 32 | Mediastinal lymphadenopathy (HP:0100721) | 3.36790549 |
| 33 | Vacuolated lymphocytes (HP:0001922) | 3.29708585 |
| 34 | Leukocytosis (HP:0001974) | 3.25070714 |
| 35 | Joint swelling (HP:0001386) | 3.23984306 |
| 36 | Abnormality of T cell physiology (HP:0011840) | 3.21123091 |
| 37 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.19156098 |
| 38 | Panhypogammaglobulinemia (HP:0003139) | 3.13650802 |
| 39 | Systemic lupus erythematosus (HP:0002725) | 3.08377060 |
| 40 | Dysostosis multiplex (HP:0000943) | 3.08053860 |
| 41 | Recurrent sinusitis (HP:0011108) | 3.07321832 |
| 42 | Chronic obstructive pulmonary disease (HP:0006510) | 3.05923155 |
| 43 | Obstructive lung disease (HP:0006536) | 3.05923155 |
| 44 | Recurrent skin infections (HP:0001581) | 3.05296048 |
| 45 | Type I transferrin isoform profile (HP:0003642) | 3.02023031 |
| 46 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.00052050 |
| 47 | Hypergammaglobulinemia (HP:0010702) | 2.98526536 |
| 48 | Nasal polyposis (HP:0100582) | 2.92559404 |
| 49 | Vasculitis (HP:0002633) | 2.90842213 |
| 50 | Autoimmune thrombocytopenia (HP:0001973) | 2.88011710 |
| 51 | Meningitis (HP:0001287) | 2.87403855 |
| 52 | Pustule (HP:0200039) | 2.84637209 |
| 53 | Recurrent bacterial skin infections (HP:0005406) | 2.83626201 |
| 54 | Abnormality of the prostate (HP:0008775) | 2.79294951 |
| 55 | Eosinophilia (HP:0001880) | 2.78069114 |
| 56 | Hemoptysis (HP:0002105) | 2.75711420 |
| 57 | Chest pain (HP:0100749) | 2.71730475 |
| 58 | Keratoconjunctivitis sicca (HP:0001097) | 2.66507724 |
| 59 | Gangrene (HP:0100758) | 2.65766151 |
| 60 | Agammaglobulinemia (HP:0004432) | 2.60268450 |
| 61 | Urticaria (HP:0001025) | 2.59862902 |
| 62 | Hypoplasia of the thymus (HP:0000778) | 2.58653403 |
| 63 | Abnormality of the pleura (HP:0002103) | 2.56405107 |
| 64 | Granulocytopenia (HP:0001913) | 2.53663501 |
| 65 | Keratoconjunctivitis (HP:0001096) | 2.53600234 |
| 66 | Disinhibition (HP:0000734) | 2.52452026 |
| 67 | Abnormality of the nasal mucosa (HP:0000433) | 2.50534392 |
| 68 | Pulmonary embolism (HP:0002204) | 2.50522339 |
| 69 | Lymphoma (HP:0002665) | 2.49591384 |
| 70 | Hepatosplenomegaly (HP:0001433) | 2.48351702 |
| 71 | Gastrointestinal infarctions (HP:0005244) | 2.47733313 |
| 72 | Petechiae (HP:0000967) | 2.46580205 |
| 73 | Pulmonary infiltrates (HP:0002113) | 2.43065016 |
| 74 | Increased serum ferritin (HP:0003281) | 2.42371813 |
| 75 | Polyneuropathy (HP:0001271) | 2.41891031 |
| 76 | Abnormality of the fingertips (HP:0001211) | 2.41531515 |
| 77 | Abnormal number of erythroid precursors (HP:0012131) | 2.36230332 |
| 78 | Loss of speech (HP:0002371) | 2.30505508 |
| 79 | IgA deficiency (HP:0002720) | 2.29713952 |
| 80 | Basal ganglia calcification (HP:0002135) | 2.29380328 |
| 81 | Chronic sinusitis (HP:0011109) | 2.29288344 |
| 82 | Retrobulbar optic neuritis (HP:0100654) | 2.29087665 |
| 83 | Optic neuritis (HP:0100653) | 2.29087665 |
| 84 | Basal cell carcinoma (HP:0002671) | 2.28086235 |
| 85 | Bronchitis (HP:0012387) | 2.26265883 |
| 86 | Abnormality of macrophages (HP:0004311) | 2.24808134 |
| 87 | Neutropenia (HP:0001875) | 2.24287657 |
| 88 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.23420574 |
| 89 | Renal cortical cysts (HP:0000803) | 2.23149390 |
| 90 | Gingivitis (HP:0000230) | 2.23033492 |
| 91 | Reticulocytopenia (HP:0001896) | 2.21736880 |
| 92 | Anorexia (HP:0002039) | 2.19814123 |
| 93 | Abnormality of B cell number (HP:0010975) | 2.19566815 |
| 94 | B lymphocytopenia (HP:0010976) | 2.19566815 |
| 95 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.19546179 |
| 96 | Mutism (HP:0002300) | 2.19289824 |
| 97 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.18820801 |
| 98 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.18820801 |
| 99 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.18820801 |
| 100 | Inflammation of the large intestine (HP:0002037) | 2.18820437 |
| 101 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.18657829 |
| 102 | Aplastic anemia (HP:0001915) | 2.18171443 |
| 103 | Restrictive lung disease (HP:0002091) | 2.17665890 |
| 104 | Microcytic anemia (HP:0001935) | 2.16999672 |
| 105 | Pulmonary fibrosis (HP:0002206) | 2.16328000 |
| 106 | Encephalitis (HP:0002383) | 2.15147547 |
| 107 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.12724821 |
| 108 | Thrombocytosis (HP:0001894) | 2.12054279 |
| 109 | Cheilitis (HP:0100825) | 2.11990456 |
| 110 | Epistaxis (HP:0000421) | 2.10956009 |
| 111 | Purpura (HP:0000979) | 2.10141147 |
| 112 | Abnormal protein glycosylation (HP:0012346) | 2.09702031 |
| 113 | Abnormal glycosylation (HP:0012345) | 2.09702031 |
| 114 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.09702031 |
| 115 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.09702031 |
| 116 | Recurrent otitis media (HP:0000403) | 2.09257078 |
| 117 | Arterial thrombosis (HP:0004420) | 2.07990344 |
| 118 | Increased IgE level (HP:0003212) | 2.07086652 |
| 119 | Gastrointestinal stroma tumor (HP:0100723) | 2.06045623 |
| 120 | Abnormality of the pericardium (HP:0001697) | 2.05600389 |
| 121 | Gastrointestinal inflammation (HP:0004386) | 2.04718737 |
| 122 | Abnormality of the columella (HP:0009929) | 2.04519145 |
| 123 | Pallor (HP:0000980) | 2.02840085 |
| 124 | Glomerulopathy (HP:0100820) | 2.02801308 |
| 125 | Abnormality of iron homeostasis (HP:0011031) | 2.01985423 |
| 126 | Orchitis (HP:0100796) | 2.01278851 |
| 127 | Prolonged bleeding time (HP:0003010) | 1.99735633 |
| 128 | Premature loss of primary teeth (HP:0006323) | 1.98416159 |
| 129 | Skin rash (HP:0000988) | 1.97583516 |
| 130 | Arthralgia (HP:0002829) | 1.96332488 |
| 131 | Cellular immunodeficiency (HP:0005374) | 1.92353534 |
| 132 | Type 2 muscle fiber atrophy (HP:0003554) | 1.91645839 |
| 133 | Spontaneous hematomas (HP:0007420) | 1.91465261 |
| 134 | Thyroid-stimulating hormone excess (HP:0002925) | 1.91153611 |
| 135 | Albinism (HP:0001022) | 1.90044996 |
| 136 | Progressive inability to walk (HP:0002505) | 1.86558369 |
| 137 | Skin ulcer (HP:0200042) | 1.77802248 |
| 138 | Large eyes (HP:0001090) | 1.77617730 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 6.32362772 |
| 2 | MAP4K1 | 5.72742302 |
| 3 | ZAP70 | 3.21758314 |
| 4 | NME2 | 2.93576779 |
| 5 | IKBKE | 2.65148315 |
| 6 | PRPF4B | 2.61703786 |
| 7 | MAP3K14 | 2.42448573 |
| 8 | JAK3 | 2.39177363 |
| 9 | EPHA3 | 2.30822835 |
| 10 | TYK2 | 2.23118438 |
| 11 | KDR | 2.20872013 |
| 12 | ITK | 2.07939582 |
| 13 | LCK | 2.01120062 |
| 14 | TAOK3 | 1.91062509 |
| 15 | TAOK2 | 1.90993474 |
| 16 | NLK | 1.83084951 |
| 17 | JAK1 | 1.82581954 |
| 18 | MATK | 1.82473912 |
| 19 | MAP3K13 | 1.80584197 |
| 20 | FGFR4 | 1.79432857 |
| 21 | ERN1 | 1.77532358 |
| 22 | MAP3K12 | 1.77410595 |
| 23 | STK10 | 1.74380816 |
| 24 | BTK | 1.71296376 |
| 25 | TEC | 1.69017802 |
| 26 | TBK1 | 1.67929550 |
| 27 | SYK | 1.66198052 |
| 28 | SIK3 | 1.65238584 |
| 29 | BCKDK | 1.65205528 |
| 30 | KIT | 1.59177979 |
| 31 | IRAK4 | 1.58848807 |
| 32 | BLK | 1.50483239 |
| 33 | LYN | 1.39705550 |
| 34 | GRK6 | 1.39166025 |
| 35 | IKBKB | 1.36315716 |
| 36 | IRAK3 | 1.35749884 |
| 37 | CLK1 | 1.29986005 |
| 38 | TNK2 | 1.23473876 |
| 39 | TAOK1 | 1.21788365 |
| 40 | HCK | 1.19381344 |
| 41 | BRD4 | 1.19025133 |
| 42 | PRKCQ | 1.18262568 |
| 43 | MST4 | 1.18150918 |
| 44 | CSK | 1.14649848 |
| 45 | FGR | 1.14379115 |
| 46 | MAP4K2 | 1.14324553 |
| 47 | SIK2 | 1.08430909 |
| 48 | MAP3K3 | 1.06415031 |
| 49 | TGFBR2 | 1.06308687 |
| 50 | TESK2 | 1.06261628 |
| 51 | ADRBK2 | 1.01039117 |
| 52 | CAMKK2 | 0.99686508 |
| 53 | PRKD2 | 0.97791105 |
| 54 | MARK3 | 0.97608771 |
| 55 | PIM2 | 0.91987507 |
| 56 | FGFR3 | 0.84672534 |
| 57 | TESK1 | 0.82616613 |
| 58 | FES | 0.77794504 |
| 59 | RIPK4 | 0.76790316 |
| 60 | CDK3 | 0.67140620 |
| 61 | RPS6KA4 | 0.66906021 |
| 62 | TNIK | 0.65335129 |
| 63 | STK16 | 0.65285463 |
| 64 | MAP3K1 | 0.64558467 |
| 65 | CDK19 | 0.63518946 |
| 66 | CHUK | 0.61814229 |
| 67 | MOS | 0.58689921 |
| 68 | NUAK1 | 0.57901507 |
| 69 | CSF1R | 0.57377677 |
| 70 | PRKCH | 0.57122208 |
| 71 | PIM1 | 0.56076631 |
| 72 | MUSK | 0.55697214 |
| 73 | FYN | 0.55573128 |
| 74 | JAK2 | 0.55571405 |
| 75 | EIF2AK2 | 0.55136605 |
| 76 | VRK1 | 0.50924208 |
| 77 | MAP2K6 | 0.50895076 |
| 78 | PRKCD | 0.50262530 |
| 79 | IGF1R | 0.49371878 |
| 80 | RPS6KA5 | 0.49266644 |
| 81 | SRPK1 | 0.46411870 |
| 82 | MYLK | 0.45061004 |
| 83 | BMPR2 | 0.44374497 |
| 84 | ABL2 | 0.41908332 |
| 85 | MAPK12 | 0.41568999 |
| 86 | MARK2 | 0.41024767 |
| 87 | CDC42BPA | 0.38965042 |
| 88 | CAMKK1 | 0.38962365 |
| 89 | MAP3K5 | 0.38932681 |
| 90 | MAPKAPK3 | 0.36651374 |
| 91 | MAPK11 | 0.36627020 |
| 92 | BRSK2 | 0.35973355 |
| 93 | DAPK1 | 0.34381574 |
| 94 | INSR | 0.33020755 |
| 95 | PDPK1 | 0.32305027 |
| 96 | STK24 | 0.29533572 |
| 97 | ACVR1B | 0.28932981 |
| 98 | NTRK2 | 0.27994820 |
| 99 | PASK | 0.27070076 |
| 100 | RAF1 | 0.26726105 |
| 101 | TYRO3 | 0.25520925 |
| 102 | LRRK2 | 0.25461456 |
| 103 | PIK3CG | 0.24947321 |
| 104 | MAP2K2 | 0.24664280 |
| 105 | ABL1 | 0.23745748 |
| 106 | HIPK2 | 0.23485302 |
| 107 | IRAK1 | 0.23176402 |
| 108 | DYRK3 | 0.21996985 |
| 109 | TRPM7 | 0.21345737 |
| 110 | MAPK4 | 0.21213101 |
| 111 | MAPK7 | 0.20972460 |
| 112 | MAPK3 | 0.20407409 |
| 113 | TLK1 | 0.20312990 |
| 114 | STK4 | 0.20036742 |
| 115 | MAPKAPK2 | 0.19314531 |
| 116 | MAP2K3 | 0.19123269 |
| 117 | DYRK1B | 0.18235693 |
| 118 | IRAK2 | 0.17099050 |
| 119 | ARAF | 0.16931679 |
| 120 | EGFR | 0.16705054 |
| 121 | MAP3K8 | 0.16527387 |
| 122 | RPS6KA6 | 0.16366934 |
| 123 | GRK7 | 0.16331560 |
| 124 | DAPK2 | 0.15781062 |
| 125 | EPHB1 | 0.15371248 |
| 126 | MAP3K11 | 0.15199251 |
| 127 | PDK1 | 0.13839402 |
| 128 | CDK4 | 0.13421881 |
| 129 | ZAK | 0.13294012 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 5.67128092 |
| 2 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 3.23472938 |
| 3 | Allograft rejection_Homo sapiens_hsa05330 | 3.20315177 |
| 4 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 3.12975195 |
| 5 | Measles_Homo sapiens_hsa05162 | 2.87000507 |
| 6 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.81470521 |
| 7 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.79156638 |
| 8 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.75399542 |
| 9 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.68974739 |
| 10 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.59986987 |
| 11 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.42534884 |
| 12 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.29065567 |
| 13 | Leishmaniasis_Homo sapiens_hsa05140 | 2.20622925 |
| 14 | Ribosome_Homo sapiens_hsa03010 | 2.18454416 |
| 15 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.92245817 |
| 16 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.81776791 |
| 17 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.73370158 |
| 18 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.50728577 |
| 19 | Viral myocarditis_Homo sapiens_hsa05416 | 1.50637553 |
| 20 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.50569621 |
| 21 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.46826654 |
| 22 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.43816878 |
| 23 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.41181063 |
| 24 | Proteasome_Homo sapiens_hsa03050 | 1.38203917 |
| 25 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.32495284 |
| 26 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.28477464 |
| 27 | DNA replication_Homo sapiens_hsa03030 | 1.26696442 |
| 28 | Asthma_Homo sapiens_hsa05310 | 1.25746861 |
| 29 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.24783003 |
| 30 | Malaria_Homo sapiens_hsa05144 | 1.21838235 |
| 31 | Spliceosome_Homo sapiens_hsa03040 | 1.21534618 |
| 32 | Mismatch repair_Homo sapiens_hsa03430 | 1.13644070 |
| 33 | Phagosome_Homo sapiens_hsa04145 | 1.13131543 |
| 34 | Legionellosis_Homo sapiens_hsa05134 | 1.12972937 |
| 35 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.10706853 |
| 36 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.10203438 |
| 37 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.09774020 |
| 38 | Base excision repair_Homo sapiens_hsa03410 | 1.07885728 |
| 39 | Shigellosis_Homo sapiens_hsa05131 | 1.04933201 |
| 40 | Influenza A_Homo sapiens_hsa05164 | 1.04698860 |
| 41 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.97993685 |
| 42 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.94736422 |
| 43 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.94193195 |
| 44 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.93899893 |
| 45 | Tuberculosis_Homo sapiens_hsa05152 | 0.93206365 |
| 46 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.92274406 |
| 47 | Hepatitis B_Homo sapiens_hsa05161 | 0.92058377 |
| 48 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.89879617 |
| 49 | HTLV-I infection_Homo sapiens_hsa05166 | 0.88913007 |
| 50 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.85850424 |
| 51 | Pertussis_Homo sapiens_hsa05133 | 0.85578247 |
| 52 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.83620926 |
| 53 | Protein export_Homo sapiens_hsa03060 | 0.83302422 |
| 54 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.79289528 |
| 55 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.78588064 |
| 56 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.75684238 |
| 57 | RNA degradation_Homo sapiens_hsa03018 | 0.74979293 |
| 58 | Salmonella infection_Homo sapiens_hsa05132 | 0.72489033 |
| 59 | Homologous recombination_Homo sapiens_hsa03440 | 0.72144150 |
| 60 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.71519412 |
| 61 | Apoptosis_Homo sapiens_hsa04210 | 0.71137894 |
| 62 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.70715046 |
| 63 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.69795151 |
| 64 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.69321965 |
| 65 | Prion diseases_Homo sapiens_hsa05020 | 0.68329846 |
| 66 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.67556116 |
| 67 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.67389371 |
| 68 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.67182505 |
| 69 | Other glycan degradation_Homo sapiens_hsa00511 | 0.64411761 |
| 70 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.64256710 |
| 71 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.59605218 |
| 72 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.57144779 |
| 73 | Hepatitis C_Homo sapiens_hsa05160 | 0.56941646 |
| 74 | RNA polymerase_Homo sapiens_hsa03020 | 0.55288219 |
| 75 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.52513915 |
| 76 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.51786530 |
| 77 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.51549060 |
| 78 | Colorectal cancer_Homo sapiens_hsa05210 | 0.48658580 |
| 79 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.48623557 |
| 80 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.48329454 |
| 81 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.45793448 |
| 82 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.45553140 |
| 83 | Platelet activation_Homo sapiens_hsa04611 | 0.44724809 |
| 84 | ABC transporters_Homo sapiens_hsa02010 | 0.43434890 |
| 85 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.43388442 |
| 86 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.43385726 |
| 87 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.41078560 |
| 88 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.39952802 |
| 89 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.35912646 |
| 90 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.35398544 |
| 91 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.34927603 |
| 92 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.32604533 |
| 93 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.30914146 |
| 94 | Lysosome_Homo sapiens_hsa04142 | 0.30331580 |
| 95 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.29784124 |
| 96 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.28177801 |
| 97 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.28051749 |
| 98 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.27788501 |
| 99 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.27597755 |
| 100 | Endocytosis_Homo sapiens_hsa04144 | 0.25190586 |
| 101 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.24194942 |
| 102 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.23999326 |
| 103 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.22916283 |
| 104 | Sulfur relay system_Homo sapiens_hsa04122 | 0.22024791 |
| 105 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.20980899 |
| 106 | Morphine addiction_Homo sapiens_hsa05032 | 0.19905911 |
| 107 | Parkinsons disease_Homo sapiens_hsa05012 | 0.19396854 |
| 108 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.17368305 |
| 109 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.17277012 |
| 110 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.17174836 |
| 111 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.16620023 |
| 112 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.16558248 |
| 113 | Bladder cancer_Homo sapiens_hsa05219 | 0.15963183 |
| 114 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.15927898 |
| 115 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.15600043 |
| 116 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.14658181 |
| 117 | Olfactory transduction_Homo sapiens_hsa04740 | 0.13941531 |
| 118 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.13496059 |
| 119 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.11685616 |
| 120 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.11566926 |
| 121 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.10278256 |
| 122 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.07329010 |
| 123 | Amoebiasis_Homo sapiens_hsa05146 | 0.02959906 |
| 124 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.02880259 |
| 125 | Galactose metabolism_Homo sapiens_hsa00052 | -0.0460066 |
| 126 | Peroxisome_Homo sapiens_hsa04146 | -0.0447877 |
| 127 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | -0.0352494 |
| 128 | Sphingolipid metabolism_Homo sapiens_hsa00600 | -0.0334149 |
| 129 | Vibrio cholerae infection_Homo sapiens_hsa05110 | -0.0031420 |
| 130 | Alzheimers disease_Homo sapiens_hsa05010 | -0.0003983 |

