IGFN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to muscle activity (GO:0014850)7.60156769
2response to stimulus involved in regulation of muscle adaptation (GO:0014874)7.35497154
3myofibril assembly (GO:0030239)6.65247922
4creatine metabolic process (GO:0006600)6.39963637
5synaptic vesicle docking involved in exocytosis (GO:0016081)6.33845622
6regulation of relaxation of muscle (GO:1901077)6.25978667
7cellular potassium ion homeostasis (GO:0030007)6.13914345
8sarcomere organization (GO:0045214)5.88443853
9positive regulation of synapse maturation (GO:0090129)5.62646038
10response to inactivity (GO:0014854)5.54929715
11regulation of short-term neuronal synaptic plasticity (GO:0048172)5.54771706
12muscle contraction (GO:0006936)5.31476215
13urinary tract smooth muscle contraction (GO:0014848)5.31423744
14regulation of synaptic vesicle exocytosis (GO:2000300)5.29354714
15synaptic vesicle exocytosis (GO:0016079)5.20716378
16glutamate secretion (GO:0014047)5.18541521
17neurotransmitter-gated ion channel clustering (GO:0072578)5.17957240
18glycogen catabolic process (GO:0005980)5.15795200
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.15145203
20synaptic vesicle maturation (GO:0016188)4.91312330
21cardiac myofibril assembly (GO:0055003)4.82513735
22striated muscle atrophy (GO:0014891)4.82352455
23glucan catabolic process (GO:0009251)4.80779620
24actomyosin structure organization (GO:0031032)4.77911743
25protein localization to synapse (GO:0035418)4.76499154
26muscle system process (GO:0003012)4.73287549
27vocalization behavior (GO:0071625)4.70970017
28skeletal muscle tissue development (GO:0007519)4.70647777
29skeletal muscle contraction (GO:0003009)4.64527966
30sarcoplasmic reticulum calcium ion transport (GO:0070296)4.62633354
31retinal rod cell development (GO:0046548)4.54713625
32actin-myosin filament sliding (GO:0033275)4.53153514
33muscle filament sliding (GO:0030049)4.53153514
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.51895858
35detection of light stimulus involved in sensory perception (GO:0050962)4.48517733
36detection of light stimulus involved in visual perception (GO:0050908)4.48517733
37response to pheromone (GO:0019236)4.48317473
38cellular polysaccharide catabolic process (GO:0044247)4.46426457
39regulation of myoblast differentiation (GO:0045661)4.43553764
40regulation of synaptic vesicle transport (GO:1902803)4.43264727
41regulation of skeletal muscle contraction (GO:0014819)4.41345331
42cardiac muscle contraction (GO:0060048)4.36636033
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.36488669
44glycogen biosynthetic process (GO:0005978)4.34152192
45glucan biosynthetic process (GO:0009250)4.34152192
46regulation of synapse maturation (GO:0090128)4.33887675
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.33463222
48muscle atrophy (GO:0014889)4.31942833
49striated muscle adaptation (GO:0014888)4.31563883
50skeletal muscle tissue regeneration (GO:0043403)4.30951337
51muscle fiber development (GO:0048747)4.27546518
52potassium ion homeostasis (GO:0055075)4.20610333
53regulation of cell communication by electrical coupling (GO:0010649)4.19980165
54carnitine shuttle (GO:0006853)4.19144345
55regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.17807836
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.07783764
57positive regulation of myoblast differentiation (GO:0045663)4.07221656
58polysaccharide catabolic process (GO:0000272)4.02050435
59NADH metabolic process (GO:0006734)3.98602309
60gluconeogenesis (GO:0006094)3.98374730
61negative regulation of myoblast differentiation (GO:0045662)3.96635036
62muscle cell fate commitment (GO:0042693)3.95790318
63layer formation in cerebral cortex (GO:0021819)3.94687780
64fructose metabolic process (GO:0006000)3.93509454
65muscle organ development (GO:0007517)3.82368219
66muscle structure development (GO:0061061)3.82191362
67positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.81193422
68actin-mediated cell contraction (GO:0070252)3.79177044
69neuronal action potential propagation (GO:0019227)3.78411480
70locomotory exploration behavior (GO:0035641)3.77155098
71response to activity (GO:0014823)3.75983123
72neuromuscular synaptic transmission (GO:0007274)3.74582015
73glycogen metabolic process (GO:0005977)3.74303618
74cardiac muscle hypertrophy (GO:0003300)3.71844891
75negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.71394601
76gamma-aminobutyric acid signaling pathway (GO:0007214)3.70986001
77positive regulation of dendritic spine morphogenesis (GO:0061003)3.69743980
78muscle adaptation (GO:0043500)3.66699897
79plasma membrane repair (GO:0001778)3.66567544
80glucan metabolic process (GO:0044042)3.65573544
81cellular glucan metabolic process (GO:0006073)3.65573544
82regulation of glutamate receptor signaling pathway (GO:1900449)3.62628469
83hexose biosynthetic process (GO:0019319)3.61562808
84regulation of skeletal muscle fiber development (GO:0048742)3.60712776
85regulation of voltage-gated calcium channel activity (GO:1901385)3.58294884
86positive regulation of myotube differentiation (GO:0010831)3.56864744
87striated muscle hypertrophy (GO:0014897)3.53653959
88neuron cell-cell adhesion (GO:0007158)3.51550712
89synaptic vesicle endocytosis (GO:0048488)3.50234083
90regulation of actin filament-based movement (GO:1903115)3.48056808
91regulation of myotube differentiation (GO:0010830)3.42206979
92muscle hypertrophy (GO:0014896)3.41964130
93regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.40935589
94long-term memory (GO:0007616)3.40398896
95neurotransmitter secretion (GO:0007269)3.37877904
96regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.36129016
97regulation of neurotransmitter secretion (GO:0046928)3.35471472
98positive regulation of membrane potential (GO:0045838)3.34529422
99fatty acid transmembrane transport (GO:1902001)3.34491739
1002-oxoglutarate metabolic process (GO:0006103)3.32037823
101myoblast fusion (GO:0007520)3.32014367
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.31033018
103postsynaptic membrane organization (GO:0001941)3.28984797
104myotube differentiation (GO:0014902)3.28643509
105striated muscle cell development (GO:0055002)3.27411433
106positive regulation of neurotransmitter secretion (GO:0001956)3.26469278
107regulation of sarcomere organization (GO:0060297)3.25719926
108regulation of calcium ion transmembrane transporter activity (GO:1901019)3.25146730
109regulation of calcium ion transmembrane transport (GO:1903169)3.25146730
110IMP metabolic process (GO:0046040)3.24748991
111muscle organ morphogenesis (GO:0048644)3.24090013
112neuromuscular junction development (GO:0007528)3.22998866
113cerebellar granule cell differentiation (GO:0021707)3.19478482
114striated muscle tissue development (GO:0014706)3.18652913
115negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.18308128
116muscle tissue morphogenesis (GO:0060415)3.16452161
117positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.16371585
118regulation of synaptic transmission, glutamatergic (GO:0051966)3.15538527
119negative regulation of potassium ion transmembrane transport (GO:1901380)3.14460093
120positive regulation of neurotransmitter transport (GO:0051590)3.13567376
121carnitine transmembrane transport (GO:1902603)3.12713950
122regulation of postsynaptic membrane potential (GO:0060078)3.12348045
123regulation of striated muscle contraction (GO:0006942)3.11803917
124sodium ion export (GO:0071436)3.11472085
125neuron-neuron synaptic transmission (GO:0007270)3.11320771
126glycolytic process (GO:0006096)3.09988629
127glutamate receptor signaling pathway (GO:0007215)3.09603614
128monosaccharide biosynthetic process (GO:0046364)3.09409562
129skeletal muscle fiber development (GO:0048741)3.08936205
130membrane hyperpolarization (GO:0060081)3.08832701
131synaptic transmission, glutamatergic (GO:0035249)3.08485468
132regulation of bile acid biosynthetic process (GO:0070857)3.07807921
133regulation of excitatory postsynaptic membrane potential (GO:0060079)3.04106096
134regulation of the force of heart contraction (GO:0002026)3.02583158
135regulation of dendritic spine morphogenesis (GO:0061001)3.02381532
136regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.01911146
137positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.00862837
138activation of protein kinase A activity (GO:0034199)3.00542973
139striated muscle contraction (GO:0006941)3.00471615
140regulation of neurotransmitter transport (GO:0051588)2.99733546
141negative regulation of necroptotic process (GO:0060546)2.99229752
142syncytium formation (GO:0006949)2.98225324
143potassium ion import (GO:0010107)2.97648914
144membrane depolarization during action potential (GO:0086010)2.96931727
145actin filament-based movement (GO:0030048)2.94928939
146positive regulation of muscle hypertrophy (GO:0014742)2.94326880
147positive regulation of cardiac muscle hypertrophy (GO:0010613)2.94326880
148righting reflex (GO:0060013)2.94227095
149regulation of synapse structural plasticity (GO:0051823)2.94119218
150regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.91159290
151adult heart development (GO:0007512)2.90889162
152syncytium formation by plasma membrane fusion (GO:0000768)2.90591103
153regulation of skeletal muscle cell differentiation (GO:2001014)2.89887648
154positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88986384
155tricarboxylic acid cycle (GO:0006099)2.88868268
1564-hydroxyproline metabolic process (GO:0019471)2.88472231
157response to histamine (GO:0034776)2.88026854
158negative regulation of cell size (GO:0045792)2.87670201
159regulation of membrane repolarization (GO:0060306)2.87489346
160cerebellar Purkinje cell differentiation (GO:0021702)2.87161734
161carnitine transport (GO:0015879)2.87130842
162amino-acid betaine transport (GO:0015838)2.87130842
163muscle cell cellular homeostasis (GO:0046716)2.87117371
164cardiac muscle cell development (GO:0055013)2.87001814
165cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.86217926
166innervation (GO:0060384)2.85710580
167negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85595657
168long-term synaptic potentiation (GO:0060291)2.84355030
169neurotransmitter transport (GO:0006836)2.82603933
170skeletal muscle adaptation (GO:0043501)2.81050806
171myotube cell development (GO:0014904)2.79003005
172negative regulation of cation channel activity (GO:2001258)2.78782616
173negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.77023737
174negative regulation of calcium ion transmembrane transport (GO:1903170)2.77023737
175regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.76931557
176regulation of cation channel activity (GO:2001257)2.76629089
177positive regulation of synaptic transmission, GABAergic (GO:0032230)2.75059598

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.19946242
2EZH2_22144423_ChIP-Seq_EOC_Human4.37034181
3GBX2_23144817_ChIP-Seq_PC3_Human3.51647329
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.47773469
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.85968558
6DROSHA_22980978_ChIP-Seq_HELA_Human2.79234206
7TBX20_22328084_ChIP-Seq_HEART_Mouse2.75646123
8TBX20_22080862_ChIP-Seq_HEART_Mouse2.75646123
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.72637824
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56445858
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49895751
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.48879188
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40090947
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40090947
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39039129
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33414073
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31975684
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31456448
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.28913291
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26556369
21LXR_22292898_ChIP-Seq_THP-1_Human2.25814175
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23558886
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.18493632
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.17668211
25REST_21632747_ChIP-Seq_MESCs_Mouse2.13589331
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13266254
27ESR2_21235772_ChIP-Seq_MCF-7_Human2.13108675
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09735202
29NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.08960683
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.01140512
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96487336
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.95899869
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.90516198
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87009591
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86853374
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.86756343
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.85988166
38AR_21572438_ChIP-Seq_LNCaP_Human1.84823191
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84818221
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.83500844
41MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.83456060
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82009776
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.75319936
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.73336706
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73056402
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72859754
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69977937
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69940025
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.69486732
50NFIB_24661679_ChIP-Seq_LUNG_Mouse1.67138740
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.66212486
52* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.60750295
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.60182038
54PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.59949502
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59482867
56RACK7_27058665_Chip-Seq_MCF-7_Human1.58492702
57* KDM2B_26808549_Chip-Seq_DND41_Human1.58267546
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.57427299
59TAF15_26573619_Chip-Seq_HEK293_Human1.56607843
60CLOCK_20551151_ChIP-Seq_293T_Human1.55570484
61ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.55166314
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.54213243
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52608640
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.52597048
65ZNF263_19887448_ChIP-Seq_K562_Human1.52152409
66SMAD4_21799915_ChIP-Seq_A2780_Human1.50650766
67GATA4_21415370_ChIP-Seq_HL-1_Mouse1.48162186
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.45820221
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45160882
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.43985073
71VDR_21846776_ChIP-Seq_THP-1_Human1.43278340
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41851554
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40354819
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39136517
75SMC4_20622854_ChIP-Seq_HELA_Human1.38324854
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37474875
77TP53_23651856_ChIP-Seq_MEFs_Mouse1.36680211
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35394141
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.35153547
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34098647
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33301433
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.33188155
83SMC3_22415368_ChIP-Seq_MEFs_Mouse1.32750089
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31807769
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29943146
86AR_19668381_ChIP-Seq_PC3_Human1.29869414
87TCF7_22412390_ChIP-Seq_EML_Mouse1.28838836
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28380039
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.27701766
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26860858
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26827845
92P68_20966046_ChIP-Seq_HELA_Human1.25936373
93* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25453200
94AR_25329375_ChIP-Seq_VCAP_Human1.24822475
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24250210
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24060739
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.24032829
98STAT3_23295773_ChIP-Seq_U87_Human1.22852438
99TP53_22127205_ChIP-Seq_IMR90_Human1.21272301
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20654300
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20607241
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.20196028
103RING1B_27294783_Chip-Seq_ESCs_Mouse1.19559867
104SMAD3_21741376_ChIP-Seq_HESCs_Human1.19439744
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18683411
106STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.18428588
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18295343
108SA1_27219007_Chip-Seq_ERYTHROID_Human1.18009587
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17601979
110PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15916767
111MYC_27129775_Chip-Seq_CORNEA_Mouse1.15868420
112DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15110781
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.13534498
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13199981
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13160914
116STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12951423
117* TCF4_23295773_ChIP-Seq_U87_Human1.12434878
118NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09327552
119* CTCF_27219007_Chip-Seq_Bcells_Human1.08695268
120SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08349486
121P300_19829295_ChIP-Seq_ESCs_Human1.07852225
122CREB1_26743006_Chip-Seq_LNCaP_Human1.07769417
123STAT1_20625510_ChIP-Seq_HELA_Human1.07652059
124SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06908750
125ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06825157
126GATA1_19941827_ChIP-Seq_MEL_Mouse1.05127445
127RXR_22158963_ChIP-Seq_LIVER_Mouse1.04565203
128YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02665156
129ESR1_21235772_ChIP-Seq_MCF-7_Human1.02612644
130KDM2B_26808549_Chip-Seq_K562_Human1.01897151
131CBP_20019798_ChIP-Seq_JUKART_Human1.01706508
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01706508
133SA1_27219007_Chip-Seq_Bcells_Human1.00665887
134EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00524728
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.99737652
136* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99173287
137DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99049155
138* ATF3_27146783_Chip-Seq_COLON_Human0.98770099
139TP63_22573176_ChIP-Seq_HFKS_Human0.98699616
140* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97864838
141TET1_21490601_ChIP-Seq_MESCs_Mouse0.97605048
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.97339925
143TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96663342
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96063656
145UBF1/2_26484160_Chip-Seq_HMECs_Human0.96006120
146FUS_26573619_Chip-Seq_HEK293_Human0.95762022
147VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95761283
148* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95749578
149TP53_16413492_ChIP-PET_HCT116_Human0.95659106
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94667796
151CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94119107
152AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93792148
153NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93425840
154ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93117785
155POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92480958
156ZNF274_21170338_ChIP-Seq_K562_Hela0.92030410
157SPI1_20517297_ChIP-Seq_HL60_Human0.92023051
158RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91991089
159SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91802858
160THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91784309
161NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91240079
162SMAD4_21741376_ChIP-Seq_HESCs_Human0.90302195
163TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89192761
164TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88632643
165TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87962406
166TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87862873
167SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87854689
168AHR_22903824_ChIP-Seq_MCF-7_Human0.87670709
169RING1B_27294783_Chip-Seq_NPCs_Mouse0.87556513
170TP53_20018659_ChIP-ChIP_R1E_Mouse0.87489565
171TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86918277
172WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86595491
173GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86554409
174ESR1_20079471_ChIP-ChIP_T-47D_Human0.86515528
175ER_23166858_ChIP-Seq_MCF-7_Human0.85732989
176BCAT_22108803_ChIP-Seq_LS180_Human0.85194545
177FLI1_21867929_ChIP-Seq_TH2_Mouse0.84109627
178OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83800393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio4.21315156
2MP0005451_abnormal_body_composition4.20362373
3MP0004859_abnormal_synaptic_plasticity4.11422653
4MP0000751_myopathy4.06807924
5MP0000749_muscle_degeneration3.86053922
6MP0004270_analgesia3.65735335
7MP0003880_abnormal_central_pattern3.22120146
8MP0004233_abnormal_muscle_weight3.01077289
9MP0005551_abnormal_eye_electrophysiolog2.93813039
10MP0003635_abnormal_synaptic_transmissio2.77570770
11MP0000747_muscle_weakness2.76662442
12MP0002090_abnormal_vision2.62943003
13MP0004036_abnormal_muscle_relaxation2.46395175
14MP0009046_muscle_twitch2.43982508
15MP0000013_abnormal_adipose_tissue2.42095073
16MP0003646_muscle_fatigue2.32598650
17MP0000759_abnormal_skeletal_muscle2.32507075
18MP0002734_abnormal_mechanical_nocicepti2.32481659
19MP0001968_abnormal_touch/_nociception2.32195308
20MP0001984_abnormal_olfaction2.24917762
21MP0002106_abnormal_muscle_physiology2.22616185
22MP0003879_abnormal_hair_cell2.19091277
23MP0002269_muscular_atrophy2.13535039
24MP0001486_abnormal_startle_reflex2.05892064
25MP0009745_abnormal_behavioral_response2.03939625
26MP0002063_abnormal_learning/memory/cond2.03531651
27MP0002064_seizures2.01703154
28MP0010386_abnormal_urinary_bladder2.00845277
29MP0004087_abnormal_muscle_fiber1.99069135
30MP0005369_muscle_phenotype1.96065469
31MP0002837_dystrophic_cardiac_calcinosis1.95667633
32MP0000750_abnormal_muscle_regeneration1.91098551
33MP0005620_abnormal_muscle_contractility1.90674788
34MP0008569_lethality_at_weaning1.90569130
35MP0005423_abnormal_somatic_nervous1.84449874
36MP0002272_abnormal_nervous_system1.82976085
37MP0000569_abnormal_digit_pigmentation1.79388196
38MP0002736_abnormal_nociception_after1.73302955
39MP0002572_abnormal_emotion/affect_behav1.71305425
40MP0004130_abnormal_muscle_cell1.67881664
41MP0002067_abnormal_sensory_capabilities1.67538299
42MP0002909_abnormal_adrenal_gland1.64121342
43MP0006036_abnormal_mitochondrial_physio1.62149716
44MP0002822_catalepsy1.61884531
45MP0000003_abnormal_adipose_tissue1.61548882
46MP0006138_congestive_heart_failure1.58386452
47MP0009780_abnormal_chondrocyte_physiolo1.47152896
48MP0002184_abnormal_innervation1.46917415
49MP0001502_abnormal_circadian_rhythm1.41197275
50MP0002108_abnormal_muscle_morphology1.40360026
51MP0010630_abnormal_cardiac_muscle1.36483395
52MP0002234_abnormal_pharynx_morphology1.36420927
53MP0004510_myositis1.36339318
54MP0001440_abnormal_grooming_behavior1.34794211
55MP0004215_abnormal_myocardial_fiber1.34287542
56MP0000733_abnormal_muscle_development1.31388819
57MP0005670_abnormal_white_adipose1.30911008
58MP0005266_abnormal_metabolism1.28797645
59MP0004185_abnormal_adipocyte_glucose1.26745769
60MP0005375_adipose_tissue_phenotype1.26627077
61MP0003868_abnormal_feces_composition1.19961908
62MP0004043_abnormal_pH_regulation1.18778899
63MP0002882_abnormal_neuron_morphology1.16862120
64MP0002332_abnormal_exercise_endurance1.16176836
65MP0006072_abnormal_retinal_apoptosis1.15946191
66MP0004811_abnormal_neuron_physiology1.14441713
67MP0001661_extended_life_span1.13949988
68MP0002735_abnormal_chemical_nociception1.10029236
69MP0001529_abnormal_vocalization1.06062396
70MP0002127_abnormal_cardiovascular_syste1.05540759
71MP0005253_abnormal_eye_physiology1.04458903
72MP0005623_abnormal_meninges_morphology1.04444425
73MP0002066_abnormal_motor_capabilities/c1.04282186
74MP0002229_neurodegeneration1.03473218
75MP0005666_abnormal_adipose_tissue1.02327358
76MP0001501_abnormal_sleep_pattern1.02186745
77MP0004924_abnormal_behavior1.01295627
78MP0005386_behavior/neurological_phenoty1.01295627
79MP0002557_abnormal_social/conspecific_i1.00314010
80MP0005385_cardiovascular_system_phenoty0.99515788
81MP0001544_abnormal_cardiovascular_syste0.99515788
82MP0003045_fibrosis0.98401783
83MP0008775_abnormal_heart_ventricle0.95816016
84MP0003950_abnormal_plasma_membrane0.93569428
85MP0000955_abnormal_spinal_cord0.92619865
86MP0006292_abnormal_olfactory_placode0.91730412
87MP0004084_abnormal_cardiac_muscle0.91455920
88MP0003221_abnormal_cardiomyocyte_apopto0.90668171
89MP0002752_abnormal_somatic_nervous0.89866698
90MP0000579_abnormal_nail_morphology0.89697260
91MP0005195_abnormal_posterior_eye0.89590711
92MP0003633_abnormal_nervous_system0.88908604
93MP0000762_abnormal_tongue_morphology0.87636579
94MP0002972_abnormal_cardiac_muscle0.86324296
95MP0001970_abnormal_pain_threshold0.85408699
96MP0005394_taste/olfaction_phenotype0.82773760
97MP0005499_abnormal_olfactory_system0.82773760
98MP0008961_abnormal_basal_metabolism0.79581901
99MP0001299_abnormal_eye_distance/0.78665713
100MP0004085_abnormal_heartbeat0.78560853
101MP0003091_abnormal_cell_migration0.76894643
102MP0005330_cardiomyopathy0.76794325
103MP0002877_abnormal_melanocyte_morpholog0.75324716
104MP0008789_abnormal_olfactory_epithelium0.73116466
105MP0010030_abnormal_orbit_morphology0.72521605
106MP0005503_abnormal_tendon_morphology0.72152601
107MP0002896_abnormal_bone_mineralization0.71984015
108MP0003705_abnormal_hypodermis_morpholog0.71752995
109MP0002638_abnormal_pupillary_reflex0.70332864
110MP0005187_abnormal_penis_morphology0.68417928
111MP0004484_altered_response_of0.66848924
112MP0002971_abnormal_brown_adipose0.66747798
113MP0010368_abnormal_lymphatic_system0.66352368
114MP0008872_abnormal_physiological_respon0.65571102
115MP0003631_nervous_system_phenotype0.65181924
116MP0001348_abnormal_lacrimal_gland0.64914156
117MP0003787_abnormal_imprinting0.64590881
118MP0001943_abnormal_respiration0.63872612
119MP0001727_abnormal_embryo_implantation0.63804303
120MP0003890_abnormal_embryonic-extraembry0.63050336
121MP0005257_abnormal_intraocular_pressure0.62980782
122MP0004858_abnormal_nervous_system0.62931586
123MP0003329_amyloid_beta_deposits0.60526499
124MP0002069_abnormal_eating/drinking_beha0.60199790
125MP0001177_atelectasis0.60103045
126MP0005646_abnormal_pituitary_gland0.59994837
127MP0005535_abnormal_body_temperature0.59218862
128MP0002089_abnormal_postnatal_growth/wei0.58050810
129MP0000681_abnormal_thyroid_gland0.57726974
130MP0000266_abnormal_heart_morphology0.57692735
131MP0003137_abnormal_impulse_conducting0.56202628
132MP0008874_decreased_physiological_sensi0.55421677
133MP0002114_abnormal_axial_skeleton0.53765598
134MP0001958_emphysema0.52920604
135MP0008438_abnormal_cutaneous_collagen0.51624168
136MP0003828_pulmonary_edema0.46860105
137MP0001849_ear_inflammation0.45886042
138MP0000534_abnormal_ureter_morphology0.45425476
139MP0005076_abnormal_cell_differentiation0.45210078
140MP0009250_abnormal_appendicular_skeleto0.43235541
141MP0002078_abnormal_glucose_homeostasis0.41271294
142MP0003385_abnormal_body_wall0.39348363
143MP0003315_abnormal_perineum_morphology0.38751931
144MP0002128_abnormal_blood_circulation0.38023195
145MP0005332_abnormal_amino_acid0.37824050
146MP0003806_abnormal_nucleotide_metabolis0.36873889
147MP0002249_abnormal_larynx_morphology0.36806631
148MP0003656_abnormal_erythrocyte_physiolo0.36800015
149MP0004134_abnormal_chest_morphology0.34682298
150MP0001346_abnormal_lacrimal_gland0.34583427
151MP0005165_increased_susceptibility_to0.34539593
152MP0003948_abnormal_gas_homeostasis0.34187035
153MP0008770_decreased_survivor_rate0.32998360
154MP0009840_abnormal_foam_cell0.30497906
155MP0004272_abnormal_basement_membrane0.30449172
156MP0005376_homeostasis/metabolism_phenot0.30249362
157MP0005023_abnormal_wound_healing0.30010524
158MP0005167_abnormal_blood-brain_barrier0.29562699
159MP0005584_abnormal_enzyme/coenzyme_acti0.28274191
160MP0005334_abnormal_fat_pad0.27015019
161MP0005452_abnormal_adipose_tissue0.25323788

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.46194762
2Exercise-induced myalgia (HP:0003738)6.17699377
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.08376666
4Muscle fiber inclusion bodies (HP:0100299)5.97561647
5Nemaline bodies (HP:0003798)5.52241567
6Round ear (HP:0100830)5.46546622
7Type 1 muscle fiber predominance (HP:0003803)5.31029662
8Fetal akinesia sequence (HP:0001989)5.21146461
9Exercise-induced muscle cramps (HP:0003710)4.84912302
10Myopathic facies (HP:0002058)4.81118431
11Distal arthrogryposis (HP:0005684)4.78506974
12Rhabdomyolysis (HP:0003201)4.63945384
13Distal lower limb muscle weakness (HP:0009053)4.63312123
14Muscle hypertrophy of the lower extremities (HP:0008968)4.23206005
15Epileptic encephalopathy (HP:0200134)4.10883993
16Focal motor seizures (HP:0011153)4.06588091
17Calf muscle hypertrophy (HP:0008981)4.04961310
18Popliteal pterygium (HP:0009756)3.95807082
19Asymmetric septal hypertrophy (HP:0001670)3.78478004
20Difficulty running (HP:0009046)3.73329612
21Rimmed vacuoles (HP:0003805)3.71728458
22Abnormality of the calf musculature (HP:0001430)3.66377092
23Ulnar deviation of the wrist (HP:0003049)3.66037118
24Areflexia of lower limbs (HP:0002522)3.54813409
25Absence seizures (HP:0002121)3.51984285
26Abnormality of the neuromuscular junction (HP:0003398)3.50970617
27Fatigable weakness (HP:0003473)3.50970617
28Central scotoma (HP:0000603)3.48973250
29Malignant hyperthermia (HP:0002047)3.43607881
30Type 2 muscle fiber atrophy (HP:0003554)3.40347379
31Abnormality of macular pigmentation (HP:0008002)3.38259590
32EMG: myopathic abnormalities (HP:0003458)3.30620797
33Gowers sign (HP:0003391)3.21207381
34Muscle fiber splitting (HP:0003555)3.18658413
35Bundle branch block (HP:0011710)3.09537730
36Abnormality of skeletal muscle fiber size (HP:0012084)3.08880785
37Febrile seizures (HP:0002373)3.08346145
38Hyporeflexia of lower limbs (HP:0002600)3.07750248
39Difficulty climbing stairs (HP:0003551)3.02208817
40Increased variability in muscle fiber diameter (HP:0003557)2.99333209
41Atonic seizures (HP:0010819)2.95255360
42Deformed tarsal bones (HP:0008119)2.94670288
43Weak cry (HP:0001612)2.90666592
44Abnormality of the calcaneus (HP:0008364)2.87747746
45Calcaneovalgus deformity (HP:0001848)2.86705514
46Muscle fiber atrophy (HP:0100295)2.86132586
47Generalized tonic-clonic seizures (HP:0002069)2.84440863
48Dialeptic seizures (HP:0011146)2.84132710
49Absent phalangeal crease (HP:0006109)2.83962989
50Amniotic constriction ring (HP:0009775)2.82159731
51Abnormality of placental membranes (HP:0011409)2.82159731
52Spinal rigidity (HP:0003306)2.79512270
53Increased corneal curvature (HP:0100692)2.73040372
54Keratoconus (HP:0000563)2.73040372
55Increased connective tissue (HP:0009025)2.72423379
56Shoulder girdle muscle weakness (HP:0003547)2.71670478
57Focal seizures (HP:0007359)2.67183177
58Severe visual impairment (HP:0001141)2.66195630
59Nonprogressive disorder (HP:0003680)2.64982023
60Akinesia (HP:0002304)2.63212044
61Bulbar palsy (HP:0001283)2.57799091
62Aplasia of the musculature (HP:0100854)2.53917163
63Myotonia (HP:0002486)2.51304304
64Myoglobinuria (HP:0002913)2.49985321
65Progressive muscle weakness (HP:0003323)2.44656444
66Visual hallucinations (HP:0002367)2.44173800
67Mildly elevated creatine phosphokinase (HP:0008180)2.37447351
68Abnormality of the foot musculature (HP:0001436)2.32612632
69Foot dorsiflexor weakness (HP:0009027)2.32136835
70Abnormal finger flexion creases (HP:0006143)2.29283934
71Pelvic girdle muscle weakness (HP:0003749)2.28272896
72Neck muscle weakness (HP:0000467)2.27460702
73Slender build (HP:0001533)2.27117955
74Frequent falls (HP:0002359)2.26306492
75Abnormality of the musculature of the pelvis (HP:0001469)2.24517129
76Abnormality of the hip-girdle musculature (HP:0001445)2.24517129
77Muscle stiffness (HP:0003552)2.24295438
78Scotoma (HP:0000575)2.23726639
79Decreased central vision (HP:0007663)2.22826650
80Centrally nucleated skeletal muscle fibers (HP:0003687)2.21093758
81Stridor (HP:0010307)2.17200407
82Lipoatrophy (HP:0100578)2.15581540
83Dilated cardiomyopathy (HP:0001644)2.14867604
84Urinary bladder sphincter dysfunction (HP:0002839)2.12878304
85Dysmetric saccades (HP:0000641)2.10861264
86Epileptiform EEG discharges (HP:0011182)2.10844979
87Progressive cerebellar ataxia (HP:0002073)2.10217861
88EEG with generalized epileptiform discharges (HP:0011198)2.09314282
89Gaze-evoked nystagmus (HP:0000640)2.08755326
90Myokymia (HP:0002411)2.08738592
91Hyperkalemia (HP:0002153)2.07341882
92Distal lower limb amyotrophy (HP:0008944)2.07187705
93Ventricular tachycardia (HP:0004756)2.06254903
94Lower limb amyotrophy (HP:0007210)2.06034896
95Generalized muscle weakness (HP:0003324)2.03036414
96Abnormal gallbladder physiology (HP:0012438)2.02573502
97Cholecystitis (HP:0001082)2.02573502
98EMG: neuropathic changes (HP:0003445)2.02285964
99Waddling gait (HP:0002515)2.02180405
100Abnormality of the shoulder girdle musculature (HP:0001435)2.02112349
101Wrist flexion contracture (HP:0001239)1.99546576
102Widely spaced teeth (HP:0000687)1.98644467
103Proximal amyotrophy (HP:0007126)1.98010244
104Ulnar bowing (HP:0003031)1.97122959
105Prolonged QT interval (HP:0001657)1.97012146
106Dysdiadochokinesis (HP:0002075)1.96887250
107Abnormal atrioventricular conduction (HP:0005150)1.96667286
108Respiratory insufficiency due to muscle weakness (HP:0002747)1.94241749
109Ankle clonus (HP:0011448)1.93227824
110Abnormal rod and cone electroretinograms (HP:0008323)1.93052515
111Hip contracture (HP:0003273)1.92065619
112Heart block (HP:0012722)1.90892176
113Sudden death (HP:0001699)1.90736118
114Broad-based gait (HP:0002136)1.87521218
115Muscular dystrophy (HP:0003560)1.85844162
116Abnormality of the lower motor neuron (HP:0002366)1.84678664
117Ventricular fibrillation (HP:0001663)1.82730579
118Limb-girdle muscle atrophy (HP:0003797)1.81925468
119Limb-girdle muscle weakness (HP:0003325)1.79216084
120Easy fatigability (HP:0003388)1.78946699
121Scapular winging (HP:0003691)1.78856678
122Abnormality of the left ventricular outflow tract (HP:0011103)1.78700521
123Subaortic stenosis (HP:0001682)1.78700521
124Achilles tendon contracture (HP:0001771)1.71951346
125Congenital hip dislocation (HP:0001374)1.69518198
126Broad face (HP:0000283)1.64830415
127Ulnar deviation of finger (HP:0009465)1.62709418
128Steppage gait (HP:0003376)1.58884094
129Metatarsus adductus (HP:0001840)1.55112106
130Long clavicles (HP:0000890)1.54513364
131Abnormality of the Achilles tendon (HP:0005109)1.52182841
132Ragged-red muscle fibers (HP:0003200)1.49095456
133Limited hip movement (HP:0008800)1.48432262
134Atrioventricular block (HP:0001678)1.48250580
135Generalized amyotrophy (HP:0003700)1.46611868
136Absent frontal sinuses (HP:0002688)1.45487366
137Fragile skin (HP:0001030)1.45207861
138Osteolytic defects of the phalanges of the hand (HP:0009771)1.43638385
139Osteolytic defects of the hand bones (HP:0009699)1.43638385
140Facial diplegia (HP:0001349)1.40770954
141Abnormality of oral frenula (HP:0000190)1.40665619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.84835547
2MAPKAPK33.34555001
3PAK63.10303519
4DAPK23.06667338
5PHKG22.93965351
6PHKG12.93965351
7NME12.86157414
8EPHA42.77254973
9STK38L2.47176376
10STK382.42926393
11PRKD32.31606628
12MAP3K42.31284420
13OBSCN2.28962691
14PRPF4B2.28149361
15MAP3K92.25904637
16TRPM71.99273116
17PINK11.98144277
18MARK11.97591784
19MAP2K41.93897222
20MAP3K131.89648772
21NEK11.85086967
22CASK1.84954319
23NTRK31.83808375
24MAP2K71.82572423
25MAP3K71.78275074
26TTN1.72785832
27EEF2K1.62442024
28RIPK11.62220904
29MINK11.53624434
30MAP2K31.52399020
31PIK3CG1.47163352
32RPS6KB21.38540346
33MUSK1.36779370
34KSR21.34477474
35DAPK11.27669416
36IRAK31.27021082
37MST1R1.26220139
38CAMKK11.25867340
39ICK1.22303317
40CAMK1G1.22239612
41FES1.19467768
42CDK51.07250876
43CAMK11.06716107
44LIMK11.05914685
45MAPK121.05684204
46PAK20.97193617
47CDK30.96568102
48NTRK20.92651168
49RPS6KA20.92160741
50PLK20.91884827
51PDK10.90190374
52TAOK20.89995456
53SIK20.87456059
54PRKAA10.87269272
55PIK3CA0.85589798
56MARK20.82482030
57INSRR0.80954605
58PKN10.80889450
59PRKD20.79880970
60PTK2B0.79557948
61CAMK1D0.78933292
62PRKCH0.78550407
63KSR10.78422023
64DYRK1A0.76631944
65RET0.76615580
66CCNB10.75305596
67CDK190.72903510
68LATS20.72607196
69FER0.72055039
70MAP3K60.71131307
71CDK140.69956637
72MAPK110.69767262
73SGK10.67952965
74MAPK130.67048382
75CDK150.66898815
76PRKCG0.66730218
77NTRK10.66426199
78NME20.66052693
79PAK30.65428244
80MET0.65185122
81CDK180.64362524
82MTOR0.63567328
83MAP2K60.63357585
84RPS6KL10.62109988
85RPS6KC10.62109988
86NEK90.61852846
87CAMK2A0.61562468
88RPS6KA30.60965534
89CAMK2D0.59943229
90CAMK40.58643258
91SIK10.58438126
92CAMK2B0.57832443
93GRK50.57575601
94TRIB30.55930965
95BRD40.54640607
96BMX0.54183707
97CDK11A0.53674783
98MOS0.53656622
99MAP2K10.52966311
100AKT30.51923250
101RPS6KA60.51740236
102PKN20.51677343
103PDK30.51288653
104PDK40.51288653
105CAMKK20.51052924
106PNCK0.50161542
107PRKAA20.50056939
108MAPK70.49245508
109PRKG10.48821737
110STK110.48361023
111TAOK10.46401462
112MAPK100.45890418
113PRKCZ0.45250061
114EPHA20.44979810
115AKT20.42853218
116BRAF0.42788912
117DMPK0.42393071
118PTK20.42345808
119PRKCA0.39666940
120DAPK30.39517219
121ERBB30.39272878
122PDPK10.38568026
123CDC42BPA0.38479767
124TNIK0.38259758
125CAMK2G0.38048289
126CDK80.37866060
127MAP3K110.37840278
128ARAF0.37081444
129ROCK10.37032068
130MAP3K100.35922217
131PDGFRA0.35153670
132ROCK20.34902202
133SGK30.32602092
134RPS6KA10.31322830
135TBK10.30342737
136DYRK1B0.28499882
137MAPK40.28067422
138IRAK20.25871191
139PDK20.25246283
140LATS10.24940257
141MAP3K10.24176884
142DDR20.24068108
143RPS6KB10.23186751
144ABL20.21336415
145EPHB10.21052752
146MAP3K30.19965427
147PAK10.19944943
148PRKD10.18265898
149YES10.17242129
150MAPKAPK20.17019886
151BCKDK0.14968571
152ERN10.14539487
153PRKACA0.13416951
154MAP2K20.13298866
155PRKACB0.12483785

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.40618699
2GABAergic synapse_Homo sapiens_hsa047272.98921198
3Nicotine addiction_Homo sapiens_hsa050332.77973271
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72687175
5Morphine addiction_Homo sapiens_hsa050322.66028327
6Olfactory transduction_Homo sapiens_hsa047402.60092386
7Insulin secretion_Homo sapiens_hsa049112.49045147
8Circadian entrainment_Homo sapiens_hsa047132.45984872
9Pentose phosphate pathway_Homo sapiens_hsa000302.45922337
10Galactose metabolism_Homo sapiens_hsa000522.24960336
11Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.17283221
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.12489048
13Glutamatergic synapse_Homo sapiens_hsa047242.10822490
14Oxytocin signaling pathway_Homo sapiens_hsa049212.10391377
15Dilated cardiomyopathy_Homo sapiens_hsa054142.09833619
16Arginine and proline metabolism_Homo sapiens_hsa003302.06003054
17Salivary secretion_Homo sapiens_hsa049702.03258060
18Carbon metabolism_Homo sapiens_hsa012001.94158874
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.94041850
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.91003218
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.90355272
22Renin secretion_Homo sapiens_hsa049241.85772262
23Circadian rhythm_Homo sapiens_hsa047101.83879162
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79050917
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78418472
26Cholinergic synapse_Homo sapiens_hsa047251.78304426
27Gastric acid secretion_Homo sapiens_hsa049711.70191085
28Calcium signaling pathway_Homo sapiens_hsa040201.64691972
29Cardiac muscle contraction_Homo sapiens_hsa042601.64603835
30Dopaminergic synapse_Homo sapiens_hsa047281.59201713
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58884816
32Long-term potentiation_Homo sapiens_hsa047201.52918224
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.50805107
34Amphetamine addiction_Homo sapiens_hsa050311.49279901
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.43298995
36Taste transduction_Homo sapiens_hsa047421.41406915
37Serotonergic synapse_Homo sapiens_hsa047261.37333507
38Starch and sucrose metabolism_Homo sapiens_hsa005001.37067916
39GnRH signaling pathway_Homo sapiens_hsa049121.35580267
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.29639006
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.28946288
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28343234
43Type II diabetes mellitus_Homo sapiens_hsa049301.27802406
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26581255
45Bladder cancer_Homo sapiens_hsa052191.26082395
46Phototransduction_Homo sapiens_hsa047441.24667382
47mTOR signaling pathway_Homo sapiens_hsa041501.13023113
48Sulfur relay system_Homo sapiens_hsa041221.12473826
49Long-term depression_Homo sapiens_hsa047301.11921868
50Collecting duct acid secretion_Homo sapiens_hsa049661.09987702
51Gap junction_Homo sapiens_hsa045401.07010018
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02841056
53cAMP signaling pathway_Homo sapiens_hsa040241.00015885
54Glioma_Homo sapiens_hsa052140.99313189
55Glucagon signaling pathway_Homo sapiens_hsa049220.98874922
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97121971
57Lysine degradation_Homo sapiens_hsa003100.93343173
58Pyruvate metabolism_Homo sapiens_hsa006200.92734086
59ECM-receptor interaction_Homo sapiens_hsa045120.92644576
60Pancreatic secretion_Homo sapiens_hsa049720.90182461
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90031492
62ErbB signaling pathway_Homo sapiens_hsa040120.85665938
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83090980
64Thyroid hormone synthesis_Homo sapiens_hsa049180.81325646
65MAPK signaling pathway_Homo sapiens_hsa040100.79203778
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77782405
67Vibrio cholerae infection_Homo sapiens_hsa051100.76837318
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75659757
69VEGF signaling pathway_Homo sapiens_hsa043700.75056361
70Insulin signaling pathway_Homo sapiens_hsa049100.74817025
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.73218789
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72611509
73Estrogen signaling pathway_Homo sapiens_hsa049150.72581007
74Nitrogen metabolism_Homo sapiens_hsa009100.71940190
75Melanogenesis_Homo sapiens_hsa049160.71579409
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.70891543
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70839540
78FoxO signaling pathway_Homo sapiens_hsa040680.70139595
79Cocaine addiction_Homo sapiens_hsa050300.68768008
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68031795
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67674772
82Thyroid cancer_Homo sapiens_hsa052160.66548126
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66517016
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65077237
85Choline metabolism in cancer_Homo sapiens_hsa052310.62505486
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62069024
87Alzheimers disease_Homo sapiens_hsa050100.61813596
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60213063
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59230763
90Phenylalanine metabolism_Homo sapiens_hsa003600.58999625
91HIF-1 signaling pathway_Homo sapiens_hsa040660.58662071
92Fatty acid degradation_Homo sapiens_hsa000710.57996310
93Fructose and mannose metabolism_Homo sapiens_hsa000510.57641265
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55937387
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55648640
96Tight junction_Homo sapiens_hsa045300.55398329
97Prolactin signaling pathway_Homo sapiens_hsa049170.54435016
98Arginine biosynthesis_Homo sapiens_hsa002200.53543173
99Inositol phosphate metabolism_Homo sapiens_hsa005620.51012487
100AMPK signaling pathway_Homo sapiens_hsa041520.50681141
101Adherens junction_Homo sapiens_hsa045200.50246157
102Axon guidance_Homo sapiens_hsa043600.49467536
103Focal adhesion_Homo sapiens_hsa045100.48640161
104Bile secretion_Homo sapiens_hsa049760.47788355
105Propanoate metabolism_Homo sapiens_hsa006400.46756168
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46370216
107Ras signaling pathway_Homo sapiens_hsa040140.46225938
108Pancreatic cancer_Homo sapiens_hsa052120.46225220
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45495744
110Small cell lung cancer_Homo sapiens_hsa052220.43643873
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42922194
112Amoebiasis_Homo sapiens_hsa051460.42655243
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42646843
114Insulin resistance_Homo sapiens_hsa049310.42328845
115Biosynthesis of amino acids_Homo sapiens_hsa012300.41770433
116Colorectal cancer_Homo sapiens_hsa052100.41323154
117African trypanosomiasis_Homo sapiens_hsa051430.39339666
118Ovarian steroidogenesis_Homo sapiens_hsa049130.37791121
119Parkinsons disease_Homo sapiens_hsa050120.37534163
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37033906
121Chronic myeloid leukemia_Homo sapiens_hsa052200.36923719
122Viral myocarditis_Homo sapiens_hsa054160.35921308
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35154954
124Renal cell carcinoma_Homo sapiens_hsa052110.34080668
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34062213
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.33466289
127Fatty acid metabolism_Homo sapiens_hsa012120.32527349
128Non-small cell lung cancer_Homo sapiens_hsa052230.32342519
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31624285
130Oocyte meiosis_Homo sapiens_hsa041140.31537296
131Wnt signaling pathway_Homo sapiens_hsa043100.31422572
132Proteoglycans in cancer_Homo sapiens_hsa052050.30990097
133Rap1 signaling pathway_Homo sapiens_hsa040150.30495968
134Endocytosis_Homo sapiens_hsa041440.29783584
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29371065
136Notch signaling pathway_Homo sapiens_hsa043300.28449242
137ABC transporters_Homo sapiens_hsa020100.28022575
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27971530
139Protein digestion and absorption_Homo sapiens_hsa049740.27512983
140Melanoma_Homo sapiens_hsa052180.25423321
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24688916
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24637158
143Glycerolipid metabolism_Homo sapiens_hsa005610.23292324
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.23108065
145beta-Alanine metabolism_Homo sapiens_hsa004100.19664221
146Other glycan degradation_Homo sapiens_hsa005110.18306712

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