IGHA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation, classical pathway (GO:0006958)7.35990713
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.50704811
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.43784048
4antigen processing and presentation of endogenous antigen (GO:0019883)6.17754191
5complement activation (GO:0006956)5.91589604
6regulation of cellular extravasation (GO:0002691)5.09353072
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.91415543
8* antimicrobial humoral response (GO:0019730)4.77809528
9* antibacterial humoral response (GO:0019731)4.74478091
10* positive regulation of respiratory burst (GO:0060267)4.59785260
11detection of bacterium (GO:0016045)4.54693935
12angiotensin maturation (GO:0002003)4.50243972
13protein activation cascade (GO:0072376)4.36784724
14detection of other organism (GO:0098543)4.35943266
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.23988965
16negative regulation of cell killing (GO:0031342)4.23988965
17positive regulation of pseudopodium assembly (GO:0031274)4.06934203
18* glomerular filtration (GO:0003094)4.04009144
19regulation of dendritic cell antigen processing and presentation (GO:0002604)4.03239970
20immunoglobulin mediated immune response (GO:0016064)4.00214547
21regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.84106545
22* humoral immune response (GO:0006959)3.76510866
23positive regulation of Cdc42 GTPase activity (GO:0043089)3.73121489
24immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.72824808
25Fc-gamma receptor signaling pathway (GO:0038094)3.72824808
26Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.72824808
27Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.71275434
28regulation of pseudopodium assembly (GO:0031272)3.62967637
29interferon-gamma-mediated signaling pathway (GO:0060333)3.62288860
30* renal filtration (GO:0097205)3.59498486
31regulation of antigen processing and presentation (GO:0002577)3.58768119
32regulation of guanylate cyclase activity (GO:0031282)3.58503724
33regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.57098942
34* regulation of respiratory burst (GO:0060263)3.48665404
35response to type I interferon (GO:0034340)3.48076926
36cellular response to type I interferon (GO:0071357)3.47914568
37type I interferon signaling pathway (GO:0060337)3.47914568
38maintenance of gastrointestinal epithelium (GO:0030277)3.47716700
39positive regulation of antigen processing and presentation (GO:0002579)3.45443118
40intestinal absorption (GO:0050892)3.30677812
41positive regulation of gamma-delta T cell activation (GO:0046645)3.17932791
42positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.13411878
43detection of external biotic stimulus (GO:0098581)3.08328447
44germinal center formation (GO:0002467)3.06897205
45peptide catabolic process (GO:0043171)3.03221639
46NIK/NF-kappaB signaling (GO:0038061)2.99952773
47B cell mediated immunity (GO:0019724)2.96157875
48dendritic cell chemotaxis (GO:0002407)2.93809568
49cellular response to interferon-gamma (GO:0071346)2.93586295
50chronic inflammatory response (GO:0002544)2.85973348
51regulation of T cell tolerance induction (GO:0002664)2.80348642
52GDP-mannose metabolic process (GO:0019673)2.78641440
53antigen processing and presentation via MHC class Ib (GO:0002475)2.77467616
54response to interferon-gamma (GO:0034341)2.76863494
55negative regulation of myotube differentiation (GO:0010832)2.75437757
56epithelial structure maintenance (GO:0010669)2.71494190
57immune response-activating cell surface receptor signaling pathway (GO:0002429)2.69864794
58oligosaccharide biosynthetic process (GO:0009312)2.69283946
59regulation of vitamin metabolic process (GO:0030656)2.67169893
60endocrine process (GO:0050886)2.66633639
61regulation of systemic arterial blood pressure by hormone (GO:0001990)2.66633639
62regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.66633639
63production of molecular mediator of immune response (GO:0002440)2.65386537
64NADH metabolic process (GO:0006734)2.65225538
65myeloid dendritic cell differentiation (GO:0043011)2.64636842
66eosinophil chemotaxis (GO:0048245)2.64121805
67regulation of necrotic cell death (GO:0010939)2.61926802
68positive regulation of guanylate cyclase activity (GO:0031284)2.59750146
69detection of biotic stimulus (GO:0009595)2.58905092
70respiratory burst (GO:0045730)2.56840413
71positive thymic T cell selection (GO:0045059)2.52155550
72eosinophil migration (GO:0072677)2.52129659
73modulation by symbiont of host defense response (GO:0052031)2.52061518
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.52061518
75modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.52061518
76positive regulation by organism of defense response of other organism involved in symbiotic interact2.52061518
77modulation by symbiont of host immune response (GO:0052553)2.52061518
78positive regulation by symbiont of host defense response (GO:0052509)2.52061518
79regulation of tolerance induction (GO:0002643)2.51642367
80dendritic cell migration (GO:0036336)2.50917389
81regulation of gamma-delta T cell activation (GO:0046643)2.49593115
82regulation of integrin activation (GO:0033623)2.49295938
83T-helper 1 type immune response (GO:0042088)2.49130595
84interferon-gamma secretion (GO:0072643)2.48328792
85myeloid dendritic cell activation (GO:0001773)2.47498600
86adhesion of symbiont to host cell (GO:0044650)2.47140727
87virion attachment to host cell (GO:0019062)2.47140727
88phospholipid scrambling (GO:0017121)2.46550112
89* retina homeostasis (GO:0001895)2.46307706
90T cell costimulation (GO:0031295)2.46096690
91lymphocyte costimulation (GO:0031294)2.42160677
92defense response to Gram-negative bacterium (GO:0050829)2.42049141
93defense response to fungus (GO:0050832)2.41985718
94defense response to protozoan (GO:0042832)2.40171383
95neutrophil activation involved in immune response (GO:0002283)2.39325210
96macrophage activation involved in immune response (GO:0002281)2.39182818
97urea cycle (GO:0000050)2.37612425
98diacylglycerol metabolic process (GO:0046339)2.36478091
99regulation of systemic arterial blood pressure (GO:0003073)2.35853578
100leukotriene metabolic process (GO:0006691)2.35189559

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.25408959
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.43645774
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.97284723
4RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.85837757
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.76629977
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.64567487
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.62871409
8CDX2_20551321_ChIP-Seq_CACO-2_Human2.59311216
9LXR_22292898_ChIP-Seq_THP-1_Human2.19116639
10VDR_21846776_ChIP-Seq_THP-1_Human2.11075620
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03399513
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.01694941
13SOX2_27498859_Chip-Seq_STOMACH_Mouse1.98445290
14VDR_24763502_ChIP-Seq_THP-1_Human1.95630657
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95040129
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93268663
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84481571
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81786097
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76834306
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75567604
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75434719
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68568250
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68370836
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68233050
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66288662
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61303613
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59550265
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.58828590
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.58757898
30RACK7_27058665_Chip-Seq_MCF-7_Human1.57115210
31PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55268178
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53384979
33TCF7_22412390_ChIP-Seq_EML_Mouse1.51297487
34MYC_22102868_ChIP-Seq_BL_Human1.49594605
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49083887
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.48165671
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.47424734
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46596278
39MAF_26560356_Chip-Seq_TH1_Human1.43477629
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43152524
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41713519
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41401834
43SOX2_20726797_ChIP-Seq_SW620_Human1.39777677
44RUNX_20019798_ChIP-Seq_JUKART_Human1.39342421
45GATA4_25053715_ChIP-Seq_YYC3_Human1.38477226
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36026300
47GATA6_25053715_ChIP-Seq_YYC3_Human1.35970594
48GATA1_19941826_ChIP-Seq_K562_Human1.35944038
49UTX_26944678_Chip-Seq_JUKART_Human1.35457375
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34325842
51CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34269561
52SPI1_23127762_ChIP-Seq_K562_Human1.34126645
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33221022
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31314839
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27451961
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26375245
57CLOCK_20551151_ChIP-Seq_293T_Human1.25277651
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.25087266
59BCL6_27268052_Chip-Seq_Bcells_Human1.24889973
60SPI1_23547873_ChIP-Seq_NB4_Human1.24865379
61MYB_26560356_Chip-Seq_TH2_Human1.24413155
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23886999
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23732029
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23270970
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.23123808
66BCOR_27268052_Chip-Seq_Bcells_Human1.22038061
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21723626
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21488186
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21084885
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.21026493
71GATA1_22025678_ChIP-Seq_K562_Human1.20957147
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20057511
73LXR_22158963_ChIP-Seq_LIVER_Mouse1.19090789
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18185636
75P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17624455
76MYB_26560356_Chip-Seq_TH1_Human1.17080389
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.15881881
78KDM2B_26808549_Chip-Seq_DND41_Human1.15512991
79SMAD_19615063_ChIP-ChIP_OVARY_Human1.15252595
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14728455
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14535507
82EGR1_19032775_ChIP-ChIP_M12_Human1.10208059
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10102070
84DROSHA_22980978_ChIP-Seq_HELA_Human1.08921178
85BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08848214
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08822111
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07808849
88GATA2_19941826_ChIP-Seq_K562_Human1.04455429
89ESR1_21235772_ChIP-Seq_MCF-7_Human1.04320553
90SCL_19346495_ChIP-Seq_HPC-7_Human1.02879789
91SA1_27219007_Chip-Seq_Bcells_Human1.02267225
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.02257601
93VDR_24787735_ChIP-Seq_THP-1_Human1.01808416
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.01700612
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00730007
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98403932
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.98332706
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98056086
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95281872
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93275298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.94336288
2MP0010234_abnormal_vibrissa_follicle3.25366645
3MP0003303_peritoneal_inflammation3.22591305
4MP0010155_abnormal_intestine_physiology3.20826139
5MP0003436_decreased_susceptibility_to2.98027541
6MP0001835_abnormal_antigen_presentation2.91421716
7MP0001790_abnormal_immune_system2.74904809
8MP0005387_immune_system_phenotype2.74904809
9MP0005360_urolithiasis2.55356770
10MP0003866_abnormal_defecation2.54684042
11MP0005025_abnormal_response_to2.42497812
12MP0002139_abnormal_hepatobiliary_system2.38096242
13MP0009785_altered_susceptibility_to2.35666898
14MP0001800_abnormal_humoral_immune2.26378092
15MP0000685_abnormal_immune_system2.26344481
16MP0001873_stomach_inflammation2.24472269
17MP0005671_abnormal_response_to2.20647520
18MP0004264_abnormal_extraembryonic_tissu2.11517452
19MP0002138_abnormal_hepatobiliary_system2.04539429
20MP0000465_gastrointestinal_hemorrhage2.01744336
21MP0005000_abnormal_immune_tolerance2.00624821
22MP0003300_gastrointestinal_ulcer1.97868191
23MP0010352_gastrointestinal_tract_polyps1.97457966
24MP0005166_decreased_susceptibility_to1.92965597
25MP0004782_abnormal_surfactant_physiolog1.92851836
26MP0003183_abnormal_peptide_metabolism1.90893418
27MP0004858_abnormal_nervous_system1.90785589
28MP0002419_abnormal_innate_immunity1.83932593
29MP0001533_abnormal_skeleton_physiology1.82156196
30MP0002452_abnormal_antigen_presenting1.79911234
31MP0002148_abnormal_hypersensitivity_rea1.77311624
32MP0001666_abnormal_nutrient_absorption1.75240153
33MP0001663_abnormal_digestive_system1.74239946
34MP0006082_CNS_inflammation1.72429842
35MP0002723_abnormal_immune_serum1.70733836
36MP0004947_skin_inflammation1.69246482
37MP0001819_abnormal_immune_cell1.68223654
38MP0002166_altered_tumor_susceptibility1.68216965
39MP0002420_abnormal_adaptive_immunity1.66553644
40MP0009379_abnormal_foot_pigmentation1.66277510
41MP0001845_abnormal_inflammatory_respons1.65909017
42MP0003191_abnormal_cellular_cholesterol1.64567296
43MP0005085_abnormal_gallbladder_physiolo1.62169987
44MP0000490_abnormal_crypts_of1.59137542
45MP0009840_abnormal_foam_cell1.54706682
46MP0009333_abnormal_splenocyte_physiolog1.48263987
47MP0001664_abnormal_digestion1.45531853
48MP0003763_abnormal_thymus_physiology1.42199426
49MP0002796_impaired_skin_barrier1.40208299
50MP0000477_abnormal_intestine_morphology1.39321303
51MP0005381_digestive/alimentary_phenotyp1.34811645
52MP0005310_abnormal_salivary_gland1.33427841
53MP0008004_abnormal_stomach_pH1.28019906
54MP0005365_abnormal_bile_salt1.21654336
55MP0000716_abnormal_immune_system1.21404006
56MP0005409_darkened_coat_color1.19176682
57MP0003075_altered_response_to1.17535562
58MP0005451_abnormal_body_composition1.16448221
59MP0002006_tumorigenesis1.11524917
60MP0008469_abnormal_protein_level1.11387360
61MP0005464_abnormal_platelet_physiology1.10585858
62MP0002998_abnormal_bone_remodeling1.10360112
63MP0004147_increased_porphyrin_level1.10320513
64MP0005058_abnormal_lysosome_morphology1.10144808
65MP0002398_abnormal_bone_marrow1.07389030
66MP0002405_respiratory_system_inflammati1.04631505
67MP0000604_amyloidosis1.03626172
68MP0003329_amyloid_beta_deposits1.01037049
69MP0003045_fibrosis1.00406691
70MP0000858_altered_metastatic_potential1.00278496
71MP0002876_abnormal_thyroid_physiology1.00004522
72MP0003448_altered_tumor_morphology0.99723273
73MP0004019_abnormal_vitamin_homeostasis0.99133287
74MP0004510_myositis0.98836511
75MP0009643_abnormal_urine_homeostasis0.98477911
76MP0000678_abnormal_parathyroid_gland0.98159084
77MP0002429_abnormal_blood_cell0.95587514
78MP0005275_abnormal_skin_tensile0.94065643
79MP0009278_abnormal_bone_marrow0.92984151
80MP0008260_abnormal_autophagy0.92369575
81MP0004043_abnormal_pH_regulation0.92014478
82MP0001765_abnormal_ion_homeostasis0.91606501
83MP0002933_joint_inflammation0.91314402
84MP0002136_abnormal_kidney_physiology0.90282129
85MP0002277_abnormal_respiratory_mucosa0.89770483
86MP0009764_decreased_sensitivity_to0.88898028
87MP0000249_abnormal_blood_vessel0.87789719
88MP0005023_abnormal_wound_healing0.86979274
89MP0000343_altered_response_to0.86886209
90MP0003806_abnormal_nucleotide_metabolis0.86781378
91MP0002722_abnormal_immune_system0.83317141
92MP0003868_abnormal_feces_composition0.83174075
93MP0003453_abnormal_keratinocyte_physiol0.82427417
94MP0005390_skeleton_phenotype0.81113573
95MP0001851_eye_inflammation0.79259231
96MP0001958_emphysema0.79155491
97MP0000689_abnormal_spleen_morphology0.77677947
98MP0001849_ear_inflammation0.70956378
99MP0002396_abnormal_hematopoietic_system0.70555222
100MP0003705_abnormal_hypodermis_morpholog0.69812849

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.92402621
2Eczematoid dermatitis (HP:0000976)5.26786667
3Malnutrition (HP:0004395)5.24850158
4Abnormality of glutamine family amino acid metabolism (HP:0010902)3.88971812
5Abnormality of macrophages (HP:0004311)3.83645979
6Hyperactive renin-angiotensin system (HP:0000841)3.74164052
7Glomerulonephritis (HP:0000099)3.63625600
8Abnormality of complement system (HP:0005339)3.62894091
9Decreased circulating renin level (HP:0003351)3.36665278
10Complement deficiency (HP:0004431)3.33043357
11Vasculitis (HP:0002633)3.29639500
12Increased IgE level (HP:0003212)3.23687685
13Colitis (HP:0002583)3.23234544
14Agammaglobulinemia (HP:0004432)3.21906510
15Gastrointestinal stroma tumor (HP:0100723)3.21808582
16Chronic diarrhea (HP:0002028)3.21259229
17Recurrent abscess formation (HP:0002722)3.19366029
18Recurrent bacterial skin infections (HP:0005406)3.18555509
19Spontaneous hematomas (HP:0007420)3.10530387
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.10066123
21Meningitis (HP:0001287)3.05246527
22Nephritis (HP:0000123)3.00470015
23Ileus (HP:0002595)2.98649658
24Cellulitis (HP:0100658)2.98069717
25Gingivitis (HP:0000230)2.97440271
26Recurrent bronchitis (HP:0002837)2.97278238
27Myositis (HP:0100614)2.96909275
28Abnormality of the nasal mucosa (HP:0000433)2.95381160
29Gastrointestinal infarctions (HP:0005244)2.94980054
30Inflammation of the large intestine (HP:0002037)2.91323187
31Orchitis (HP:0100796)2.84877126
32Metabolic alkalosis (HP:0200114)2.82989116
33Gastrointestinal inflammation (HP:0004386)2.81439271
34Premature loss of primary teeth (HP:0006323)2.78395944
35Emphysema (HP:0002097)2.77105108
36Abnormality of small intestinal villus morphology (HP:0011472)2.69276550
37Villous atrophy (HP:0011473)2.69276550
38Abnormality of renin-angiotensin system (HP:0000847)2.67873285
39Hemorrhage of the eye (HP:0011885)2.67267431
40Recurrent gram-negative bacterial infections (HP:0005420)2.65645140
41Osteomyelitis (HP:0002754)2.65620367
42Abnormality of monocarboxylic acid metabolism (HP:0010996)2.62407210
43Chronic obstructive pulmonary disease (HP:0006510)2.61271795
44Obstructive lung disease (HP:0006536)2.61271795
45Chronic otitis media (HP:0000389)2.60570896
46Elevated erythrocyte sedimentation rate (HP:0003565)2.60546285
47Urticaria (HP:0001025)2.59459760
48Alkalosis (HP:0001948)2.57791026
49Hemoptysis (HP:0002105)2.51750768
50Mediastinal lymphadenopathy (HP:0100721)2.49705235
51Recurrent fungal infections (HP:0002841)2.44417815
52Pustule (HP:0200039)2.44254943
53Skin rash (HP:0000988)2.44110061
54Flat acetabular roof (HP:0003180)2.38198543
55Pulmonary infiltrates (HP:0002113)2.37774470
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.37382675
57Recurrent viral infections (HP:0004429)2.36806727
58Interstitial pulmonary disease (HP:0006530)2.34389101
59Nasal polyposis (HP:0100582)2.29693340
60Recurrent skin infections (HP:0001581)2.26088532
61Right ventricular cardiomyopathy (HP:0011663)2.24796998
62Retrobulbar optic neuritis (HP:0100654)2.23472084
63Optic neuritis (HP:0100653)2.23472084
64Encephalitis (HP:0002383)2.16141528
65Abnormality of proline metabolism (HP:0010907)2.15808105
66Hydroxyprolinuria (HP:0003080)2.15808105
67Restrictive lung disease (HP:0002091)2.15398490
68Chest pain (HP:0100749)2.13580789
69Polycythemia (HP:0001901)2.13560560
70Petechiae (HP:0000967)2.12982982
71Abnormality of B cell number (HP:0010975)2.11329031
72Hypergammaglobulinemia (HP:0010702)2.11301871
73Gastrointestinal dysmotility (HP:0002579)2.10978905
74Purpura (HP:0000979)2.10395625
75Recurrent sinusitis (HP:0011108)2.09194514
76Keratoconjunctivitis sicca (HP:0001097)2.03965520
77Recurrent cutaneous fungal infections (HP:0011370)2.03507453
78Chronic mucocutaneous candidiasis (HP:0002728)2.03507453
79Thin bony cortex (HP:0002753)2.01356030
80Panhypogammaglobulinemia (HP:0003139)2.00850174
81Recurrent pneumonia (HP:0006532)2.00335805
82Segmental peripheral demyelination/remyelination (HP:0003481)2.00095122
83Leukocytosis (HP:0001974)1.97353120
84Prostate neoplasm (HP:0100787)1.95997502
85Abdominal distention (HP:0003270)1.95665375
86Abnormality of the prostate (HP:0008775)1.95508901
87Abnormality of T cell physiology (HP:0011840)1.94014094
88Skin ulcer (HP:0200042)1.91742248
89Bronchitis (HP:0012387)1.91398890
90Recurrent lower respiratory tract infections (HP:0002783)1.90896097
91Lymphopenia (HP:0001888)1.90324659
92Hematochezia (HP:0002573)1.90275010
93Autoimmune thrombocytopenia (HP:0001973)1.89562724
94Widely patent fontanelles and sutures (HP:0004492)1.86699368
95Abnormality of the pleura (HP:0002103)1.86117347
96Cerebral palsy (HP:0100021)1.85690100
97Increased IgM level (HP:0003496)1.83595460
98Keratoconjunctivitis (HP:0001096)1.81545180
99Amyloidosis (HP:0011034)1.81442036
100Growth hormone excess (HP:0000845)1.81366316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.57850411
2MAP4K13.54120796
3MST1R3.37329036
4RIPK43.12346787
5TYK23.00864972
6RIPK12.90375679
7PRPF4B2.65004409
8FGFR42.50230220
9ACVR1B2.16785969
10EPHB12.13077352
11BLK2.04758787
12EPHA31.98663649
13EPHA21.97003831
14GRK61.80392458
15CDC42BPA1.76391812
16ZAP701.75102289
17PIK3CA1.70988267
18MAP3K101.61663367
19IKBKE1.59290927
20JAK11.58184811
21CSK1.57740710
22SMG11.54840707
23TRIB31.52220007
24PRKG21.50078350
25JAK31.48830128
26TAOK11.48820255
27PTK61.48522492
28TBK11.47199071
29KIT1.47139201
30IRAK41.44297152
31MAP3K141.43175311
32MAP3K11.37641991
33FGFR31.33854354
34FES1.27479333
35MAP3K111.15078002
36SYK1.15038917
37MATK1.11595365
38JAK21.10316285
39BTK1.10173185
40EPHB21.09291625
41LYN1.08285754
42TXK1.06300113
43MAP3K31.04255032
44TESK21.01393533
45MAP2K30.96523768
46TNK20.93755471
47CSF1R0.92912141
48MET0.89620784
49HCK0.88564697
50IRAK10.87727914
51MAP3K130.86908056
52LMTK20.86195311
53DDR20.85931598
54STK240.83243286
55PDPK10.81646890
56MAP2K20.81391435
57SIK30.81057347
58NLK0.80921672
59TGFBR20.78596330
60FGR0.74568188
61LCK0.74021735
62MAP3K60.73784490
63FER0.71294829
64PKN20.67955203
65MAPK70.67747567
66PRKD20.67290866
67HIPK20.64875719
68TESK10.64087128
69PDK10.62127322
70LRRK20.61906605
71RET0.60516124
72FYN0.59917728
73SIK10.59651373
74YES10.59009873
75BMX0.56365154
76IKBKB0.56090478
77PDGFRA0.55084654
78MAP3K20.52714452
79MYLK0.51541012
80TAOK20.51270056
81BMPR20.49918910
82MAPKAPK20.49896162
83MAP2K60.49879599
84ITK0.49421532
85KSR20.49121279
86MAPK110.49055972
87OXSR10.46364227
88DMPK0.40754394
89KDR0.40250814
90RPS6KL10.38191789
91RPS6KC10.38191789
92PAK40.37392479
93TEC0.36757292
94MAP3K70.34981245
95SRC0.34934382
96DYRK1B0.34082477
97PRKCQ0.33972227
98IRAK30.33617866
99ERBB20.32455794
100PDGFRB0.32221702

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.34765574
2Staphylococcus aureus infection_Homo sapiens_hsa051503.22658626
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.19449172
4Allograft rejection_Homo sapiens_hsa053303.05589925
5Autoimmune thyroid disease_Homo sapiens_hsa053202.90550047
6Graft-versus-host disease_Homo sapiens_hsa053322.88063236
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.82377259
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.55594333
9Type I diabetes mellitus_Homo sapiens_hsa049402.32451673
10Leishmaniasis_Homo sapiens_hsa051402.30294835
11Fat digestion and absorption_Homo sapiens_hsa049752.06973181
12Antigen processing and presentation_Homo sapiens_hsa046122.01493831
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93207570
14Sulfur metabolism_Homo sapiens_hsa009201.84929486
15Renin-angiotensin system_Homo sapiens_hsa046141.79603902
16Viral myocarditis_Homo sapiens_hsa054161.74928321
17Arginine biosynthesis_Homo sapiens_hsa002201.63209375
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61123357
19Fructose and mannose metabolism_Homo sapiens_hsa000511.51237044
20Primary immunodeficiency_Homo sapiens_hsa053401.50379691
21Pertussis_Homo sapiens_hsa051331.42869615
22Other glycan degradation_Homo sapiens_hsa005111.41312801
23Toxoplasmosis_Homo sapiens_hsa051451.40470641
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36348946
25Mineral absorption_Homo sapiens_hsa049781.35951972
26Osteoclast differentiation_Homo sapiens_hsa043801.35793676
27Tuberculosis_Homo sapiens_hsa051521.29810851
28Hematopoietic cell lineage_Homo sapiens_hsa046401.24655823
29Influenza A_Homo sapiens_hsa051641.23955802
30B cell receptor signaling pathway_Homo sapiens_hsa046621.16570473
31Vitamin digestion and absorption_Homo sapiens_hsa049771.09776269
32Histidine metabolism_Homo sapiens_hsa003401.09461590
33Protein digestion and absorption_Homo sapiens_hsa049741.08830120
34Rheumatoid arthritis_Homo sapiens_hsa053231.04168480
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03337088
36Hepatitis C_Homo sapiens_hsa051601.00268783
37Herpes simplex infection_Homo sapiens_hsa051681.00177228
38NF-kappa B signaling pathway_Homo sapiens_hsa040640.99466838
39Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99167022
40Leukocyte transendothelial migration_Homo sapiens_hsa046700.98802151
41Chemokine signaling pathway_Homo sapiens_hsa040620.97472822
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97309072
43Caffeine metabolism_Homo sapiens_hsa002320.94056555
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90827093
45Arachidonic acid metabolism_Homo sapiens_hsa005900.90496156
46Phagosome_Homo sapiens_hsa041450.89376643
47TNF signaling pathway_Homo sapiens_hsa046680.87602976
48Pancreatic secretion_Homo sapiens_hsa049720.83986525
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81771859
50African trypanosomiasis_Homo sapiens_hsa051430.80971234
51Linoleic acid metabolism_Homo sapiens_hsa005910.79542535
52Galactose metabolism_Homo sapiens_hsa000520.77415119
53Malaria_Homo sapiens_hsa051440.77094322
54PPAR signaling pathway_Homo sapiens_hsa033200.74353574
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74269214
56Starch and sucrose metabolism_Homo sapiens_hsa005000.73913446
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73197228
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.70254958
59Nitrogen metabolism_Homo sapiens_hsa009100.67429586
60Complement and coagulation cascades_Homo sapiens_hsa046100.66879221
61Glycerolipid metabolism_Homo sapiens_hsa005610.65854878
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64710379
63Acute myeloid leukemia_Homo sapiens_hsa052210.63939768
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62567977
65Measles_Homo sapiens_hsa051620.62404705
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62057367
67Bile secretion_Homo sapiens_hsa049760.59912487
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59106929
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58140590
70Amoebiasis_Homo sapiens_hsa051460.56662160
71Ether lipid metabolism_Homo sapiens_hsa005650.56162130
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55212710
73Salmonella infection_Homo sapiens_hsa051320.54968368
74Fatty acid degradation_Homo sapiens_hsa000710.53935638
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53171481
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.51857093
77Retinol metabolism_Homo sapiens_hsa008300.50030609
78Arginine and proline metabolism_Homo sapiens_hsa003300.48975314
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48756497
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.48331834
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47043298
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43739248
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42840315
84Apoptosis_Homo sapiens_hsa042100.42662099
85Chemical carcinogenesis_Homo sapiens_hsa052040.39556915
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39313015
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.38695898
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37448012
89Lysosome_Homo sapiens_hsa041420.37320996
90T cell receptor signaling pathway_Homo sapiens_hsa046600.36891452
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36280163
92Platelet activation_Homo sapiens_hsa046110.33654819
93Thyroid hormone synthesis_Homo sapiens_hsa049180.33436399
94Hepatitis B_Homo sapiens_hsa051610.33399534
95GnRH signaling pathway_Homo sapiens_hsa049120.33174535
96Prion diseases_Homo sapiens_hsa050200.32535074
97Legionellosis_Homo sapiens_hsa051340.30921050
98Insulin resistance_Homo sapiens_hsa049310.30714757
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28259336
100Prolactin signaling pathway_Homo sapiens_hsa049170.27549131

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