IGHD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)9.84067357
2antigen processing and presentation of endogenous antigen (GO:0019883)8.82057615
3myeloid dendritic cell differentiation (GO:0043011)8.02804415
4cellular response to zinc ion (GO:0071294)7.55271733
5myeloid dendritic cell activation (GO:0001773)7.09444213
6positive regulation of gamma-delta T cell activation (GO:0046645)7.05666697
7regulation of B cell differentiation (GO:0045577)6.40721326
8apoptotic cell clearance (GO:0043277)6.14144857
9positive thymic T cell selection (GO:0045059)6.08864384
10regulation of B cell receptor signaling pathway (GO:0050855)5.87458919
11Golgi transport vesicle coating (GO:0048200)5.75381462
12COPI coating of Golgi vesicle (GO:0048205)5.75381462
13hepatocyte apoptotic process (GO:0097284)5.66542975
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.61621515
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.61621515
16cellular extravasation (GO:0045123)5.59550128
17regulation of gamma-delta T cell differentiation (GO:0045586)5.57418899
18B cell proliferation (GO:0042100)5.42599311
19positive regulation of B cell differentiation (GO:0045579)5.42563180
20mature B cell differentiation (GO:0002335)5.28393902
21regulation of gamma-delta T cell activation (GO:0046643)5.03573541
22dendritic cell differentiation (GO:0097028)5.00272563
23negative regulation of bone remodeling (GO:0046851)4.96964046
24negative regulation of B cell proliferation (GO:0030889)4.84698299
25positive regulation of Rap GTPase activity (GO:0032854)4.81943700
26regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.73529406
27regulation of interferon-beta biosynthetic process (GO:0045357)4.71294853
28regulation of B cell proliferation (GO:0030888)4.66032550
29ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.64638240
30cellular response to interleukin-15 (GO:0071350)4.63351181
31antigen receptor-mediated signaling pathway (GO:0050851)4.57277883
32negative regulation of histone methylation (GO:0031061)4.54455801
33response to interleukin-15 (GO:0070672)4.54208206
34regulation of alpha-beta T cell proliferation (GO:0046640)4.48982153
35regulation of interleukin-12 biosynthetic process (GO:0045075)4.47332575
36response to hydroperoxide (GO:0033194)4.41750355
37positive T cell selection (GO:0043368)4.34193328
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.31846723
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.30171283
40thymic T cell selection (GO:0045061)4.29383451
41defense response to protozoan (GO:0042832)4.29305274
42regulation of dendritic cell antigen processing and presentation (GO:0002604)4.27719979
43mannose metabolic process (GO:0006013)4.27433554
44negative thymic T cell selection (GO:0045060)4.24975341
45negative regulation of fibroblast apoptotic process (GO:2000270)4.24257650
46activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.22549360
47T cell migration (GO:0072678)4.21698599
48regulation of B cell apoptotic process (GO:0002902)4.21178837
49positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.20721691
50negative regulation of humoral immune response (GO:0002921)4.18590836
51regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.14133725
52positive regulation of nuclease activity (GO:0032075)4.12033472
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.10751181
54complement activation, classical pathway (GO:0006958)4.08573590
55lymph node development (GO:0048535)4.08032703
56negative regulation of tissue remodeling (GO:0034104)4.06276160
57regulation of Rap GTPase activity (GO:0032317)4.04982529
58protein retention in ER lumen (GO:0006621)4.02832978
59protein N-linked glycosylation via asparagine (GO:0018279)4.02276063
60T cell selection (GO:0045058)4.00678228
61peptidyl-asparagine modification (GO:0018196)3.98462448
62positive regulation of B cell proliferation (GO:0030890)3.94001036
63long term synaptic depression (GO:0060292)3.91645709
64immune response-activating cell surface receptor signaling pathway (GO:0002429)3.91409637
65negative T cell selection (GO:0043383)3.88470010
66NIK/NF-kappaB signaling (GO:0038061)3.86164706
67B cell activation (GO:0042113)3.82773353
68signal peptide processing (GO:0006465)3.80775181
69phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.78234915
70SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.77929532
71regulation of nuclease activity (GO:0032069)3.77078528
72regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.74877612
73negative regulation of B cell apoptotic process (GO:0002903)3.74186068
74immunoglobulin mediated immune response (GO:0016064)3.74052162
75protein targeting to ER (GO:0045047)3.70494724
76B cell homeostasis (GO:0001782)3.70300115
77protein N-linked glycosylation (GO:0006487)3.69984185
78mature B cell differentiation involved in immune response (GO:0002313)3.69712323
79cotranslational protein targeting to membrane (GO:0006613)3.69431018
80response to endoplasmic reticulum stress (GO:0034976)3.65618586
81mast cell activation (GO:0045576)3.62920629
82regulation of superoxide anion generation (GO:0032928)3.62463702
83positive regulation of histone deacetylation (GO:0031065)3.62223678
84positive regulation of antigen processing and presentation (GO:0002579)3.60714213
85endoplasmic reticulum unfolded protein response (GO:0030968)3.59530662
86positive regulation of immunoglobulin production (GO:0002639)3.57639422
87lymphocyte homeostasis (GO:0002260)3.57059086
88positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.57008367
89establishment of protein localization to endoplasmic reticulum (GO:0072599)3.56198686
90response to protozoan (GO:0001562)3.52078848
91cellular response to unfolded protein (GO:0034620)3.50903837
92response to interferon-alpha (GO:0035455)3.48832773
93regulation of type I interferon-mediated signaling pathway (GO:0060338)3.47313541
94germinal center formation (GO:0002467)3.47106705
95mast cell activation involved in immune response (GO:0002279)3.46881731
96mast cell degranulation (GO:0043303)3.46881731
97negative regulation of phagocytosis (GO:0050765)3.46638200
98positive regulation of interferon-alpha production (GO:0032727)3.46626783
99positive regulation of B cell activation (GO:0050871)3.44997469
100positive regulation of interleukin-2 production (GO:0032743)3.44102545
101regulation of B cell activation (GO:0050864)3.44069306
102T cell homeostasis (GO:0043029)3.43707618
103protein localization to endoplasmic reticulum (GO:0070972)3.42989507
104negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.41920604
105mitochondrion distribution (GO:0048311)3.41063164
106negative regulation of cell killing (GO:0031342)3.40643002
107negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.40643002
108respiratory burst (GO:0045730)3.37242641
109regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.36625315
110cellular response to antibiotic (GO:0071236)3.34724225
111T cell costimulation (GO:0031295)3.33915120
112interferon-gamma-mediated signaling pathway (GO:0060333)3.33510093
113cell redox homeostasis (GO:0045454)3.32027742
114regulation of fibroblast apoptotic process (GO:2000269)3.29396115
115regulation of interferon-alpha production (GO:0032647)3.27318999
116activation of JUN kinase activity (GO:0007257)3.26099122
117lymphocyte costimulation (GO:0031294)3.25809328
118ER-nucleus signaling pathway (GO:0006984)3.23171697
119cellular response to topologically incorrect protein (GO:0035967)3.21588908
120UDP-N-acetylglucosamine metabolic process (GO:0006047)3.18452000
121modulation by virus of host process (GO:0019054)3.18116413
122regulation of triglyceride catabolic process (GO:0010896)3.17417732
123regulation of MHC class I biosynthetic process (GO:0045343)3.14027342
124mononuclear cell proliferation (GO:0032943)3.12975493
125negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.12186729
126lymphocyte proliferation (GO:0046651)3.11916823
127negative regulation of alpha-beta T cell activation (GO:0046636)3.10899382
128antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10182661
129cellular response to type I interferon (GO:0071357)3.10004557
130type I interferon signaling pathway (GO:0060337)3.10004557
131N-terminal protein amino acid acetylation (GO:0006474)3.09310270
132complement activation (GO:0006956)3.09273119
133leukocyte homeostasis (GO:0001776)3.08585342
134negative regulation of bone resorption (GO:0045779)3.07736855
135cellular hyperosmotic response (GO:0071474)3.06951045
136CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.05886361
137response to type I interferon (GO:0034340)3.05600564
138positive regulation of macrophage cytokine production (GO:0060907)3.05232637
139regulation of histone H3-K9 methylation (GO:0051570)3.05162214
140B cell differentiation (GO:0030183)3.04291994
141Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.02096817
142immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.02096817
143Fc-gamma receptor signaling pathway (GO:0038094)3.02096817
144I-kappaB phosphorylation (GO:0007252)2.99337661
145phagocytosis (GO:0006909)2.99083824
146response to laminar fluid shear stress (GO:0034616)2.97830299
147Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.97150141
148modulation by symbiont of host cellular process (GO:0044068)2.94644659
149regulation of antigen processing and presentation (GO:0002577)2.93943079
150negative regulation of nitric-oxide synthase activity (GO:0051001)2.93682828
151retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.93517017
152viral transcription (GO:0019083)2.93152841
153lymphocyte chemotaxis (GO:0048247)2.93048901
154JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.92770491
155interleukin-6-mediated signaling pathway (GO:0070102)2.92233421
156chaperone mediated protein folding requiring cofactor (GO:0051085)2.92048926
157cytoplasmic mRNA processing body assembly (GO:0033962)2.91257164
158immune response-activating signal transduction (GO:0002757)2.90974922
159regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.90292047
160histone H3-K36 demethylation (GO:0070544)2.88503197
161tolerance induction (GO:0002507)2.88128991
162myeloid leukocyte activation (GO:0002274)2.87387477
163positive regulation of cell adhesion mediated by integrin (GO:0033630)2.86788549
164negative regulation of mast cell activation (GO:0033004)2.86750927
165response to muramyl dipeptide (GO:0032495)2.85332930
166mitochondrial calcium ion transport (GO:0006851)2.85327298
167positive regulation of granulocyte differentiation (GO:0030854)2.84413405
168regulation of T cell receptor signaling pathway (GO:0050856)2.83709961
169cellular response to exogenous dsRNA (GO:0071360)2.82757441
170serine transport (GO:0032329)2.81582802
171peptidyl-proline hydroxylation (GO:0019511)2.81135856
172negative regulation of complement activation (GO:0045916)2.80866036
173regulation of interleukin-2 biosynthetic process (GO:0045076)2.75731468
174regulation of T cell mediated cytotoxicity (GO:0001914)2.75495413
175mRNA modification (GO:0016556)2.72862154
176T cell proliferation (GO:0042098)2.72739379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.38524750
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.37766513
3MYC_22102868_ChIP-Seq_BL_Human5.13789632
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.54307367
5SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.09948175
6VDR_21846776_ChIP-Seq_THP-1_Human3.64947863
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.64689950
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56407306
9E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.25119785
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.18118425
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.06589023
12IRF8_27001747_Chip-Seq_BMDM_Mouse3.06576760
13RUNX_20019798_ChIP-Seq_JUKART_Human2.99850659
14MAF_26560356_Chip-Seq_TH1_Human2.72057938
15MYB_26560356_Chip-Seq_TH1_Human2.67973107
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56371895
17MYB_26560356_Chip-Seq_TH2_Human2.56173024
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.54339342
19UTX_26944678_Chip-Seq_JUKART_Human2.49197347
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36424348
21TCF7_22412390_ChIP-Seq_EML_Mouse2.35876816
22VDR_24763502_ChIP-Seq_THP-1_Human2.33004146
23KDM2B_26808549_Chip-Seq_SUP-B15_Human2.29344151
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.28142370
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26948496
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24836695
27KDM2B_26808549_Chip-Seq_DND41_Human2.23403040
28CIITA_25753668_ChIP-Seq_RAJI_Human2.22235558
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.20212406
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15755622
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.09246740
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00009566
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99154086
34SPI1_23547873_ChIP-Seq_NB4_Human1.93490915
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85317078
36SCL_19346495_ChIP-Seq_HPC-7_Human1.84042404
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.82849901
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81091968
39MAF_26560356_Chip-Seq_TH2_Human1.79754612
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79634391
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.78991100
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75855130
43TFEB_21752829_ChIP-Seq_HELA_Human1.73520867
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71234088
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.70347826
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70129630
47GATA1_22025678_ChIP-Seq_K562_Human1.67700334
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67381890
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60163426
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59750518
51GATA3_27048872_Chip-Seq_THYMUS_Human1.59253633
52SPI1_23127762_ChIP-Seq_K562_Human1.58623194
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58449149
54PU.1_20513432_ChIP-Seq_Bcells_Mouse1.52919101
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43022540
56XRN2_22483619_ChIP-Seq_HELA_Human1.41238956
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41101298
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36407383
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36340280
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30194281
61VDR_23849224_ChIP-Seq_CD4+_Human1.30185978
62FOXP3_21729870_ChIP-Seq_TREG_Human1.29941305
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27503290
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27202315
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26574292
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26134486
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25235524
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24967610
69PU_27001747_Chip-Seq_BMDM_Mouse1.24758555
70MYC_18555785_ChIP-Seq_MESCs_Mouse1.21825945
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.20920234
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20598958
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19256010
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18775656
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17788921
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16991450
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16273772
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15751624
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15288619
80LXR_22292898_ChIP-Seq_THP-1_Human1.14961694
81MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13430124
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11617390
83MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09083812
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08984655
85NCOR1_26117541_ChIP-Seq_K562_Human1.08800796
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06845212
87ETS1_20019798_ChIP-Seq_JURKAT_Human1.05858812
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03776734
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02313581
90EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00845356
91GATA3_26560356_Chip-Seq_TH2_Human1.00225914
92RACK7_27058665_Chip-Seq_MCF-7_Human0.99954009
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98813013
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97852187
95DCP1A_22483619_ChIP-Seq_HELA_Human0.97698745
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97093168
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96680480
98YY1_21170310_ChIP-Seq_MESCs_Mouse0.96559045
99GATA1_19941827_ChIP-Seq_MEL_Mouse0.93701226
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92520970
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92241429
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91877900
103ETS1_21867929_ChIP-Seq_TH2_Mouse0.91798163
104CHD1_26751641_Chip-Seq_LNCaP_Human0.91497162
105P300_27268052_Chip-Seq_Bcells_Human0.91049761
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89044788
107BCL6_27268052_Chip-Seq_Bcells_Human0.88296312
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87856616
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87375602
110SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86522329
111SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.86471056
112CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85969821
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83445040
114BCOR_27268052_Chip-Seq_Bcells_Human0.82878250
115SMRT_27268052_Chip-Seq_Bcells_Human0.81268919
116E2F7_22180533_ChIP-Seq_HELA_Human0.80361299
117GATA3_26560356_Chip-Seq_TH1_Human0.79961929
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.79579394
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79143044
120RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78796022
121KDM5A_27292631_Chip-Seq_BREAST_Human0.77193285
122ELF1_20517297_ChIP-Seq_JURKAT_Human0.76812136
123CTCF_26484167_Chip-Seq_Bcells_Mouse0.76421587
124SPI1_20517297_ChIP-Seq_HL60_Human0.75626566
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75087021
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75050463
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.73407785
128BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.72335521
129FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70067884
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.69922127
131ERG_20887958_ChIP-Seq_HPC-7_Mouse0.69853569
132GATA1_19941826_ChIP-Seq_K562_Human0.68800070
133LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.67621926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation6.08142333
2* MP0005387_immune_system_phenotype5.37568530
3* MP0001790_abnormal_immune_system5.37568530
4* MP0001800_abnormal_humoral_immune5.25420251
5* MP0002452_abnormal_antigen_presenting3.88009129
6MP0003303_peritoneal_inflammation3.70286742
7MP0000685_abnormal_immune_system3.59069626
8MP0005000_abnormal_immune_tolerance3.52819806
9MP0004264_abnormal_extraembryonic_tissu3.29391125
10* MP0002723_abnormal_immune_serum3.17510353
11* MP0002420_abnormal_adaptive_immunity3.11306171
12MP0005671_abnormal_response_to3.08399223
13* MP0001819_abnormal_immune_cell2.99916656
14MP0002398_abnormal_bone_marrow2.92464481
15* MP0000716_abnormal_immune_system2.70144344
16MP0000689_abnormal_spleen_morphology2.67965124
17MP0004510_myositis2.43200360
18MP0003763_abnormal_thymus_physiology2.37225626
19MP0005058_abnormal_lysosome_morphology2.21293434
20* MP0002429_abnormal_blood_cell2.16269517
21MP0002722_abnormal_immune_system2.15279240
22MP0003300_gastrointestinal_ulcer2.08671436
23MP0001873_stomach_inflammation2.07779771
24MP0002419_abnormal_innate_immunity2.05354796
25MP0002148_abnormal_hypersensitivity_rea2.04622569
26MP0005025_abnormal_response_to2.02451349
27MP0005220_abnormal_exocrine_pancreas2.01679620
28MP0004084_abnormal_cardiac_muscle1.99855196
29MP0003183_abnormal_peptide_metabolism1.86415939
30MP0010307_abnormal_tumor_latency1.85899758
31MP0003252_abnormal_bile_duct1.80468222
32MP0001845_abnormal_inflammatory_respons1.74615794
33MP0009785_altered_susceptibility_to1.73952246
34MP0001270_distended_abdomen1.73221189
35MP0003136_yellow_coat_color1.72844160
36MP0001853_heart_inflammation1.69552851
37MP0002396_abnormal_hematopoietic_system1.69319469
38MP0002166_altered_tumor_susceptibility1.69162657
39MP0002405_respiratory_system_inflammati1.65959875
40MP0003436_decreased_susceptibility_to1.64485327
41MP0005451_abnormal_body_composition1.62201321
42MP0004808_abnormal_hematopoietic_stem1.59296140
43MP0002909_abnormal_adrenal_gland1.53480465
44MP0010155_abnormal_intestine_physiology1.52360857
45MP0005171_absent_coat_pigmentation1.46325012
46MP0000703_abnormal_thymus_morphology1.41592495
47MP0005310_abnormal_salivary_gland1.38917814
48MP0010234_abnormal_vibrissa_follicle1.34487610
49MP0004947_skin_inflammation1.32434604
50MP0008995_early_reproductive_senescence1.27822248
51MP0009333_abnormal_splenocyte_physiolog1.27181291
52MP0003091_abnormal_cell_migration1.26730788
53MP0005464_abnormal_platelet_physiology1.26456233
54MP0003866_abnormal_defecation1.25537778
55MP0000465_gastrointestinal_hemorrhage1.24394947
56MP0002933_joint_inflammation1.24213440
57MP0000858_altered_metastatic_potential1.19401627
58MP0002876_abnormal_thyroid_physiology1.15133023
59MP0004036_abnormal_muscle_relaxation1.14997879
60MP0008057_abnormal_DNA_replication1.13932700
61MP0002136_abnormal_kidney_physiology1.12319111
62MP0004782_abnormal_surfactant_physiolog1.09409605
63MP0008961_abnormal_basal_metabolism1.08727083
64MP0003045_fibrosis1.05425485
65MP0002006_tumorigenesis1.03289591
66MP0003693_abnormal_embryo_hatching1.01741378
67MP0003787_abnormal_imprinting0.97636162
68MP0008874_decreased_physiological_sensi0.97582459
69MP0008469_abnormal_protein_level0.97105425
70MP0001764_abnormal_homeostasis0.96874067
71MP0005174_abnormal_tail_pigmentation0.95775041
72MP0002928_abnormal_bile_duct0.94985621
73MP0001879_abnormal_lymphatic_vessel0.92114402
74MP0000681_abnormal_thyroid_gland0.91778651
75MP0003191_abnormal_cellular_cholesterol0.91700172
76MP0003890_abnormal_embryonic-extraembry0.91318797
77MP0002138_abnormal_hepatobiliary_system0.90653870
78MP0003566_abnormal_cell_adhesion0.87353714
79MP0001944_abnormal_pancreas_morphology0.86660771
80MP0001919_abnormal_reproductive_system0.86605901
81MP0000569_abnormal_digit_pigmentation0.86541279
82MP0000313_abnormal_cell_death0.85399305
83MP0002019_abnormal_tumor_incidence0.84142750
84MP0010352_gastrointestinal_tract_polyps0.83767790
85MP0008260_abnormal_autophagy0.83613044
86MP0003724_increased_susceptibility_to0.83131465
87MP0005503_abnormal_tendon_morphology0.82937147
88MP0003656_abnormal_erythrocyte_physiolo0.82679195
89MP0002168_other_aberrant_phenotype0.81195525
90MP0003786_premature_aging0.75474471
91MP0005390_skeleton_phenotype0.74367019
92MP0001851_eye_inflammation0.73466628
93MP0004883_abnormal_blood_vessel0.71695673
94MP0003221_abnormal_cardiomyocyte_apopto0.68328377
95MP0000767_abnormal_smooth_muscle0.68307946
96MP0006054_spinal_hemorrhage0.67627845
97MP0000598_abnormal_liver_morphology0.66920955
98MP0003279_aneurysm0.66070880
99MP0001986_abnormal_taste_sensitivity0.65816001
100MP0003943_abnormal_hepatobiliary_system0.65593636
101MP0009278_abnormal_bone_marrow0.65149618
102MP0000249_abnormal_blood_vessel0.63136894
103MP0003077_abnormal_cell_cycle0.61941344
104MP0004134_abnormal_chest_morphology0.61842966
105MP0005621_abnormal_cell_physiology0.61701370
106MP0005076_abnormal_cell_differentiation0.59757839
107MP0005408_hypopigmentation0.57415580
108MP0003453_abnormal_keratinocyte_physiol0.55217873
109MP0001663_abnormal_digestive_system0.54934252
110MP0009840_abnormal_foam_cell0.54864010
111MP0000613_abnormal_salivary_gland0.52855164
112MP0009764_decreased_sensitivity_to0.51659081
113MP0008569_lethality_at_weaning0.51151812
114MP0002078_abnormal_glucose_homeostasis0.51147945
115MP0006082_CNS_inflammation0.50713939
116MP0000609_abnormal_liver_physiology0.50120503
117MP0000350_abnormal_cell_proliferation0.49849254
118MP0005584_abnormal_enzyme/coenzyme_acti0.49405004
119MP0000604_amyloidosis0.49398709
120MP0002095_abnormal_skin_pigmentation0.48797294
121MP0002254_reproductive_system_inflammat0.48691585
122MP0000733_abnormal_muscle_development0.47578835
123MP0005397_hematopoietic_system_phenotyp0.46277166
124MP0001545_abnormal_hematopoietic_system0.46277166
125MP0000371_diluted_coat_color0.45441475
126MP0000490_abnormal_crypts_of0.44799057
127MP0003172_abnormal_lysosome_physiology0.43833732
128MP0003828_pulmonary_edema0.43403808
129MP0001533_abnormal_skeleton_physiology0.43083635
130MP0002135_abnormal_kidney_morphology0.43053349
131MP0000015_abnormal_ear_pigmentation0.42359783
132MP0001784_abnormal_fluid_regulation0.41895281
133MP0010630_abnormal_cardiac_muscle0.41730451
134MP0002009_preneoplasia0.41303264
135MP0002693_abnormal_pancreas_physiology0.40083445
136MP0005023_abnormal_wound_healing0.39427078
137MP0002083_premature_death0.38423593
138MP0005384_cellular_phenotype0.37270424

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.98819305
2Gastrointestinal stroma tumor (HP:0100723)8.13083557
3Recurrent bronchitis (HP:0002837)6.79951665
4Colitis (HP:0002583)6.34919819
5Recurrent sinusitis (HP:0011108)6.29543070
6Cellulitis (HP:0100658)5.86985577
7Verrucae (HP:0200043)5.38004185
8Papilloma (HP:0012740)5.38004185
9Inflammation of the large intestine (HP:0002037)5.31060616
10Gastrointestinal inflammation (HP:0004386)5.09516037
11Emphysema (HP:0002097)5.02899695
12Lymphopenia (HP:0001888)4.96452281
13IgM deficiency (HP:0002850)4.92691072
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.92688015
15Panhypogammaglobulinemia (HP:0003139)4.77782275
16Abnormality of cells of the lymphoid lineage (HP:0012140)4.68024743
17Recurrent viral infections (HP:0004429)4.52668028
18Small epiphyses (HP:0010585)4.52497229
19Chronic sinusitis (HP:0011109)4.40305551
20Mitral stenosis (HP:0001718)4.34803083
21Meningitis (HP:0001287)4.30864206
22Chronic otitis media (HP:0000389)4.19435550
23Bronchitis (HP:0012387)3.92788676
24Recurrent otitis media (HP:0000403)3.92589885
25Restrictive lung disease (HP:0002091)3.90300106
26Vasculitis (HP:0002633)3.88583662
27Osteomyelitis (HP:0002754)3.58240681
28Recurrent cutaneous fungal infections (HP:0011370)3.57195842
29Chronic mucocutaneous candidiasis (HP:0002728)3.57195842
30Vertebral arch anomaly (HP:0008438)3.50550822
31Hypercortisolism (HP:0001578)3.48164562
32Abnormality of macrophages (HP:0004311)3.44405618
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.39925887
34Viral hepatitis (HP:0006562)3.35509709
35Recurrent abscess formation (HP:0002722)3.31844605
36Recurrent bacterial skin infections (HP:0005406)3.30067757
37Abnormality of the fingertips (HP:0001211)3.26598035
38Recurrent lower respiratory tract infections (HP:0002783)3.21823055
39Recurrent pneumonia (HP:0006532)3.21253855
40Lower limb hyperreflexia (HP:0002395)3.15300625
41Recurrent fungal infections (HP:0002841)3.15132501
42Homocystinuria (HP:0002156)3.14370507
43Abnormality of homocysteine metabolism (HP:0010919)3.14370507
44IgA deficiency (HP:0002720)3.13184653
45Recurrent gram-negative bacterial infections (HP:0005420)3.08906975
46Mediastinal lymphadenopathy (HP:0100721)3.02891613
47Sepsis (HP:0100806)2.99978586
48Flattened epiphyses (HP:0003071)2.94708099
49Urticaria (HP:0001025)2.94547356
50Recurrent skin infections (HP:0001581)2.94329482
51Hypergammaglobulinemia (HP:0010702)2.83734645
52Hypoplasia of the capital femoral epiphysis (HP:0003090)2.80178145
53Exocrine pancreatic insufficiency (HP:0001738)2.78371836
54Chronic diarrhea (HP:0002028)2.75940766
55Ulnar bowing (HP:0003031)2.73515214
56Autoimmune hemolytic anemia (HP:0001890)2.70042803
57Leukopenia (HP:0001882)2.59592757
58Abnormality of T cell physiology (HP:0011840)2.56528339
59Abnormality of T cells (HP:0002843)2.55022609
60Dysostosis multiplex (HP:0000943)2.52228244
61Lymphoma (HP:0002665)2.51559564
62Spondylolisthesis (HP:0003302)2.47173430
63Irregular vertebral endplates (HP:0003301)2.46498824
64B lymphocytopenia (HP:0010976)2.44651233
65Abnormality of B cell number (HP:0010975)2.44651233
66Arthropathy (HP:0003040)2.43286458
67T lymphocytopenia (HP:0005403)2.38953112
68Pustule (HP:0200039)2.36776138
69Nasal polyposis (HP:0100582)2.35951204
70Thyroiditis (HP:0100646)2.32247777
71Encephalitis (HP:0002383)2.31667653
72Autoimmune thrombocytopenia (HP:0001973)2.30349545
73Granulocytopenia (HP:0001913)2.30344907
74Overlapping toe (HP:0001845)2.29394097
75IgG deficiency (HP:0004315)2.28005189
76Eczematoid dermatitis (HP:0000976)2.27066250
77Elevated erythrocyte sedimentation rate (HP:0003565)2.26160412
78Abnormality of T cell number (HP:0011839)2.25369039
79Hyperparathyroidism (HP:0000843)2.25135232
80Pulmonary infiltrates (HP:0002113)2.24416480
81Fatigue (HP:0012378)2.23073341
82Spastic paraparesis (HP:0002313)2.21898034
83Absent epiphyses (HP:0010577)2.21831945
84Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.21831945
85Spontaneous hematomas (HP:0007420)2.21309421
86Papilledema (HP:0001085)2.19647019
87Skin ulcer (HP:0200042)2.18363912
88Thyroid-stimulating hormone excess (HP:0002925)2.17758176
89Nonimmune hydrops fetalis (HP:0001790)2.16423785
90Abnormality of small intestinal villus morphology (HP:0011472)2.13246823
91Villous atrophy (HP:0011473)2.13246823
92Thrombocytosis (HP:0001894)2.13094780
93Resting tremor (HP:0002322)2.12148116
94Xerostomia (HP:0000217)2.11779774
95Gingival bleeding (HP:0000225)2.11494681
96Interstitial pulmonary disease (HP:0006530)2.09327457
97Skin rash (HP:0000988)2.08726600
98Limited elbow extension (HP:0001377)2.04871514
99Short middle phalanx of the 5th finger (HP:0004220)2.03059575
100Hematochezia (HP:0002573)2.03001126
101Arthralgia (HP:0002829)2.00797639
102Hepatitis (HP:0012115)2.00766829
103Macrocytic anemia (HP:0001972)2.00511664
104Abnormality of the thoracic spine (HP:0100711)2.00425623
105Loss of speech (HP:0002371)1.98112551
106Neoplasm of head and neck (HP:0012288)1.97323383
107Esophageal neoplasm (HP:0100751)1.97323383
108Deep palmar crease (HP:0006191)1.96899364
109Abnormality of glycolipid metabolism (HP:0010969)1.96725165
110Abnormality of liposaccharide metabolism (HP:0010968)1.96725165
111Abnormality of glycosphingolipid metabolism (HP:0004343)1.96725165
112Abnormality of the nasal mucosa (HP:0000433)1.95358135
113Large for gestational age (HP:0001520)1.94496453
114Abnormality of cells of the erythroid lineage (HP:0012130)1.93612819
115Facial diplegia (HP:0001349)1.93115814
116Global brain atrophy (HP:0002283)1.92786936
117Myocardial infarction (HP:0001658)1.92631553
118Chronic obstructive pulmonary disease (HP:0006510)1.91815061
119Obstructive lung disease (HP:0006536)1.91815061
120Neutropenia (HP:0001875)1.91724632
121Abnormality of the intervertebral disk (HP:0005108)1.91621634
122Acrocyanosis (HP:0001063)1.90880086
123Increased IgE level (HP:0003212)1.90270696
124Eosinophilia (HP:0001880)1.90266622
125Exercise-induced myalgia (HP:0003738)1.89778015
126Rhabdomyolysis (HP:0003201)1.89700828
127Syringomyelia (HP:0003396)1.88635023
128Spinal cord lesions (HP:0100561)1.88635023
129Malnutrition (HP:0004395)1.86421192
130Myositis (HP:0100614)1.86349078
131Easy fatigability (HP:0003388)1.85438930
132Severe combined immunodeficiency (HP:0004430)1.84407431
133Abnormality of the vertebral endplates (HP:0005106)1.84047315
134Gingivitis (HP:0000230)1.82397601
135Hyperthyroidism (HP:0000836)1.82152375
136Chest pain (HP:0100749)1.81764765
137Aortic regurgitation (HP:0001659)1.81553475
138Barrel-shaped chest (HP:0001552)1.77317709
139Basal cell carcinoma (HP:0002671)1.76117134
140Hypertensive crisis (HP:0100735)1.75808439
141Cubitus valgus (HP:0002967)1.73299617
142Periodontitis (HP:0000704)1.71214883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK37.16896146
2MAP4K16.98779232
3PIK3CG5.79706710
4GRK63.96917374
5MAP3K133.62440318
6PRPF4B3.23152948
7MAP3K102.86526873
8ERN12.84561868
9LRRK22.79753778
10CSF1R2.78264542
11RIPK42.69321645
12STK102.63429276
13MAP3K142.61771274
14BTK2.57724213
15SYK2.53524887
16BLK2.42676244
17SIK22.32353023
18TYK22.00666563
19CDK121.93158398
20TESK21.92377199
21GRK11.92212291
22JAK11.83953556
23SIK31.60039145
24ARAF1.59547029
25MARK31.55410825
26MST41.50831274
27LYN1.49155919
28IRAK31.46149928
29TGFBR21.45924970
30KIT1.39733635
31HCK1.31930679
32SIK11.30942949
33CSK1.28352607
34IKBKB1.22628058
35ITK1.21983782
36BRD41.21916037
37MAP3K91.13151783
38EEF2K1.11966632
39JAK31.11811342
40CDC42BPA1.09995858
41TEC1.08137434
42TBK11.07606072
43PRKD21.03913170
44CDK31.03759389
45IRAK41.01793672
46CCNB11.01293885
47EIF2AK31.00687358
48PRKCQ0.96889361
49CAMK1G0.96285529
50LCK0.95991851
51TNK20.92933563
52ZAP700.91054967
53CAMK1D0.90131456
54FES0.88120163
55PIM10.82250645
56ALK0.82049651
57CHUK0.80329333
58NEK90.76935613
59MAPK70.76595148
60MAP3K70.76348425
61FGFR30.75584894
62WNK10.74550918
63MATK0.73667298
64BRAF0.72832421
65MAPK120.72669206
66STK40.72386625
67PRKCH0.72369586
68HIPK20.71414943
69PDK10.67867418
70ABL10.66320519
71MAP2K30.66079404
72IKBKE0.64719940
73FGFR40.64385273
74KSR20.63946761
75CDK60.62224646
76BMPR20.59775561
77NME20.58119933
78CLK10.56202974
79MOS0.54955006
80RPS6KA40.54892619
81INSR0.54204974
82PRKD10.54178952
83TRIB30.50597821
84SCYL20.50344855
85FYN0.49955373
86EIF2AK10.49477077
87MAP3K110.45485896
88TTN0.44320290
89CSNK1A1L0.44105963
90RAF10.44037807
91SGK30.43737388
92RPS6KB20.43649303
93CDK90.43449070
94PTK60.43119063
95FGR0.42357019
96CDK40.42324044
97MAPK110.42164287
98MAP3K10.42082415
99TXK0.41953974
100RPS6KC10.39183471
101RPS6KL10.39183471
102MARK20.38896366
103DYRK1B0.37950435
104EPHB10.37159507
105EGFR0.34109671
106JAK20.33258890
107STK240.32303536
108CDK80.31963596
109PIM20.31505490
110MELK0.31274936
111PAK40.30678102
112RPS6KA60.28864392
113STK110.27183077
114CHEK10.26213332
115MAPK40.25630232
116PRKCD0.25207905
117PKN20.24409251
118MAP3K80.24396929
119SRPK10.23124155
120PDPK10.23044768
121MAP2K10.22905540
122TAOK20.20689056
123SMG10.20560852
124CSNK1G10.19880668
125MAPK30.18762135
126ROCK20.18659215
127MAP2K20.17968970
128SGK20.17451284
129CSNK1D0.17216327
130YES10.16426360
131DYRK1A0.16420642
132TNIK0.16145048
133SRC0.15430398
134NLK0.14087850
135CSNK1G30.13919899
136NEK20.13782690

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046626.83387600
2Primary immunodeficiency_Homo sapiens_hsa053406.27222177
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.11638793
4Protein export_Homo sapiens_hsa030603.65308309
5N-Glycan biosynthesis_Homo sapiens_hsa005103.55788579
6Hematopoietic cell lineage_Homo sapiens_hsa046403.54010737
7Autoimmune thyroid disease_Homo sapiens_hsa053203.07826116
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.95859491
9Allograft rejection_Homo sapiens_hsa053302.73343043
10Graft-versus-host disease_Homo sapiens_hsa053322.44678087
11Osteoclast differentiation_Homo sapiens_hsa043802.34347609
12Antigen processing and presentation_Homo sapiens_hsa046122.22439185
13Asthma_Homo sapiens_hsa053102.19579559
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.19474409
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.13512653
16T cell receptor signaling pathway_Homo sapiens_hsa046602.10366970
17Other glycan degradation_Homo sapiens_hsa005112.05692616
18Type I diabetes mellitus_Homo sapiens_hsa049401.97753169
19Leishmaniasis_Homo sapiens_hsa051401.94522062
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.90945575
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.86626615
22Chemokine signaling pathway_Homo sapiens_hsa040621.74902342
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71896655
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66463159
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.65554656
26Tuberculosis_Homo sapiens_hsa051521.50832943
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43469525
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42139546
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.39344048
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39158167
31Herpes simplex infection_Homo sapiens_hsa051681.38959305
32Platelet activation_Homo sapiens_hsa046111.33398106
33Measles_Homo sapiens_hsa051621.33133511
34Staphylococcus aureus infection_Homo sapiens_hsa051501.32820280
35Epstein-Barr virus infection_Homo sapiens_hsa051691.30996834
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.21660154
37Toxoplasmosis_Homo sapiens_hsa051451.20976380
38Non-small cell lung cancer_Homo sapiens_hsa052231.16465914
39Chronic myeloid leukemia_Homo sapiens_hsa052201.10142326
40Shigellosis_Homo sapiens_hsa051311.07762616
41Influenza A_Homo sapiens_hsa051641.05821801
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.05472430
43Hepatitis B_Homo sapiens_hsa051611.04671507
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04663979
45Acute myeloid leukemia_Homo sapiens_hsa052211.04469849
46Lysine degradation_Homo sapiens_hsa003101.01272245
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97845743
48Pancreatic cancer_Homo sapiens_hsa052120.97520034
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92056126
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.90062283
51Endometrial cancer_Homo sapiens_hsa052130.88911183
52Apoptosis_Homo sapiens_hsa042100.88660327
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86801472
54African trypanosomiasis_Homo sapiens_hsa051430.85531788
55Viral myocarditis_Homo sapiens_hsa054160.83176477
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82948548
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82262922
58MAPK signaling pathway_Homo sapiens_hsa040100.81787900
59VEGF signaling pathway_Homo sapiens_hsa043700.79363838
60Hepatitis C_Homo sapiens_hsa051600.78569447
61Dorso-ventral axis formation_Homo sapiens_hsa043200.77074738
62TNF signaling pathway_Homo sapiens_hsa046680.73210100
63Insulin resistance_Homo sapiens_hsa049310.69253716
64FoxO signaling pathway_Homo sapiens_hsa040680.68973076
65Rheumatoid arthritis_Homo sapiens_hsa053230.68902959
66Lysosome_Homo sapiens_hsa041420.68504367
67Base excision repair_Homo sapiens_hsa034100.67621365
68HTLV-I infection_Homo sapiens_hsa051660.66870671
69Viral carcinogenesis_Homo sapiens_hsa052030.65146556
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64295125
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63208228
72mTOR signaling pathway_Homo sapiens_hsa041500.63189769
73Notch signaling pathway_Homo sapiens_hsa043300.62825364
74Renal cell carcinoma_Homo sapiens_hsa052110.60737968
75Malaria_Homo sapiens_hsa051440.59858140
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59579091
77Small cell lung cancer_Homo sapiens_hsa052220.58092423
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.57223709
79Proteoglycans in cancer_Homo sapiens_hsa052050.55587544
80Non-homologous end-joining_Homo sapiens_hsa034500.55336411
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55283018
82Endocytosis_Homo sapiens_hsa041440.55171323
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54458610
84Vibrio cholerae infection_Homo sapiens_hsa051100.53801842
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53702214
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53281047
87Pertussis_Homo sapiens_hsa051330.51253874
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50369874
89Salmonella infection_Homo sapiens_hsa051320.49667803
90MicroRNAs in cancer_Homo sapiens_hsa052060.49230594
91Phagosome_Homo sapiens_hsa041450.48607707
92GnRH signaling pathway_Homo sapiens_hsa049120.48098779
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47827159
94Prolactin signaling pathway_Homo sapiens_hsa049170.47614932
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46554243
96Inositol phosphate metabolism_Homo sapiens_hsa005620.46503786
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45769952
98Long-term potentiation_Homo sapiens_hsa047200.45721316
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.44793239
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44361058
101Glioma_Homo sapiens_hsa052140.43797658
102Colorectal cancer_Homo sapiens_hsa052100.43785332
103One carbon pool by folate_Homo sapiens_hsa006700.42788847
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42449532
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38954493
106Choline metabolism in cancer_Homo sapiens_hsa052310.38216066
107ErbB signaling pathway_Homo sapiens_hsa040120.37756584
108Prostate cancer_Homo sapiens_hsa052150.36986658
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36698720
110Glucagon signaling pathway_Homo sapiens_hsa049220.35408459
111Estrogen signaling pathway_Homo sapiens_hsa049150.34773560
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.34093518
113Type II diabetes mellitus_Homo sapiens_hsa049300.31916142
114Thyroid hormone synthesis_Homo sapiens_hsa049180.31805517
115Legionellosis_Homo sapiens_hsa051340.31711474
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31512947
117Ribosome_Homo sapiens_hsa030100.31003183
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30157442
119Bladder cancer_Homo sapiens_hsa052190.27968850
120Rap1 signaling pathway_Homo sapiens_hsa040150.27310127
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26656865
122Pathways in cancer_Homo sapiens_hsa052000.26641279
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26340342
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26277184
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25788440
126Insulin signaling pathway_Homo sapiens_hsa049100.25132888
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24647311
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.23821330
129mRNA surveillance pathway_Homo sapiens_hsa030150.23571269
130Systemic lupus erythematosus_Homo sapiens_hsa053220.23264689
131Renin secretion_Homo sapiens_hsa049240.23194096
132HIF-1 signaling pathway_Homo sapiens_hsa040660.22866302
133ABC transporters_Homo sapiens_hsa020100.21468653
134Spliceosome_Homo sapiens_hsa030400.21415590

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