IGHG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)9.17924463
2* complement activation (GO:0006956)8.45174826
3glomerular filtration (GO:0003094)7.73467043
4renal filtration (GO:0097205)7.00253502
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.24576542
6* protein activation cascade (GO:0072376)6.20477436
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.18414350
8antimicrobial humoral response (GO:0019730)6.10599567
9regulation of respiratory burst (GO:0060263)6.02590968
10antibacterial humoral response (GO:0019731)6.00388624
11antigen processing and presentation of endogenous antigen (GO:0019883)5.82574243
12* humoral immune response (GO:0006959)5.14328776
13regulation of cellular extravasation (GO:0002691)4.81810647
14* Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)4.78861746
15* immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00024.78861746
16* Fc-gamma receptor signaling pathway (GO:0038094)4.78861746
17* Fc receptor mediated stimulatory signaling pathway (GO:0002431)4.76532791
18regulation of dendritic cell antigen processing and presentation (GO:0002604)4.54654125
19retina homeostasis (GO:0001895)4.42083361
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.20893346
21detection of bacterium (GO:0016045)4.20602606
22immunoglobulin mediated immune response (GO:0016064)4.10217649
23regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.03743612
24detection of other organism (GO:0098543)4.01709353
25regulation of antigen processing and presentation (GO:0002577)3.99489864
26germinal center formation (GO:0002467)3.91222412
27positive regulation of pseudopodium assembly (GO:0031274)3.89012018
28interferon-gamma-mediated signaling pathway (GO:0060333)3.88350536
29positive regulation of antigen processing and presentation (GO:0002579)3.83117276
30angiotensin maturation (GO:0002003)3.76060134
31positive regulation of Cdc42 GTPase activity (GO:0043089)3.58085303
32chronic inflammatory response (GO:0002544)3.56089911
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54031929
34negative regulation of cell killing (GO:0031342)3.54031929
35regulation of integrin activation (GO:0033623)3.50696897
36regulation of pseudopodium assembly (GO:0031272)3.48727113
37cellular response to type I interferon (GO:0071357)3.36326441
38type I interferon signaling pathway (GO:0060337)3.36326441
39response to type I interferon (GO:0034340)3.36096370
40positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.17252443
41cellular response to interferon-gamma (GO:0071346)3.16624956
42* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.12280726
43regulation of glucose import in response to insulin stimulus (GO:2001273)3.08826913
44response to interferon-gamma (GO:0034341)3.04941056
45T-helper 1 type immune response (GO:0042088)3.01456348
46myeloid dendritic cell differentiation (GO:0043011)3.01082376
47B cell mediated immunity (GO:0019724)3.00889838
48NIK/NF-kappaB signaling (GO:0038061)2.97794725
49regulation of T cell tolerance induction (GO:0002664)2.95047056
50eosinophil chemotaxis (GO:0048245)2.92736127
51positive regulation of T cell migration (GO:2000406)2.89309636
52detection of external biotic stimulus (GO:0098581)2.87469238
53adhesion of symbiont to host cell (GO:0044650)2.86656366
54virion attachment to host cell (GO:0019062)2.86656366
55peptide catabolic process (GO:0043171)2.83398349
56protein-chromophore linkage (GO:0018298)2.83166361
57regulation of T cell migration (GO:2000404)2.80186851
58positive regulation of gamma-delta T cell activation (GO:0046645)2.79993394
59maintenance of gastrointestinal epithelium (GO:0030277)2.79647935
60keratinization (GO:0031424)2.79137272
61myeloid dendritic cell activation (GO:0001773)2.71743502
62eosinophil migration (GO:0072677)2.69008204
63regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.67336586
64dendritic cell chemotaxis (GO:0002407)2.66684005
65GDP-mannose metabolic process (GO:0019673)2.65745119
66positive regulation of granulocyte chemotaxis (GO:0071624)2.62046253
67defense response to Gram-negative bacterium (GO:0050829)2.60856525
68production of molecular mediator of immune response (GO:0002440)2.58838313
69positive regulation of lymphocyte migration (GO:2000403)2.58287133
70regulation of tolerance induction (GO:0002643)2.57545744
71regulation of type I interferon-mediated signaling pathway (GO:0060338)2.55813165
72T cell costimulation (GO:0031295)2.55166663
73regulation of necrotic cell death (GO:0010939)2.53148603
74surfactant homeostasis (GO:0043129)2.51643428
75lymphocyte costimulation (GO:0031294)2.51189373
76regulation of regulatory T cell differentiation (GO:0045589)2.48468038
77antigen processing and presentation via MHC class Ib (GO:0002475)2.45673892
78regulation of T-helper 1 cell differentiation (GO:0045625)2.44795588
79phosphatidylserine acyl-chain remodeling (GO:0036150)2.44742429
80endothelial cell chemotaxis (GO:0035767)2.44360847
81* activation of immune response (GO:0002253)2.43596184
82establishment of skin barrier (GO:0061436)2.42664741
83detection of biotic stimulus (GO:0009595)2.42122898
84regulation of monocyte chemotaxis (GO:0090025)2.41762673
85* immune response-activating signal transduction (GO:0002757)2.41266564
86regulation of water loss via skin (GO:0033561)2.41150338
87positive regulation of receptor recycling (GO:0001921)2.41146897
88adhesion of symbiont to host (GO:0044406)2.38765581
89phosphatidylinositol acyl-chain remodeling (GO:0036149)2.38511910
90negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.38085040
91regulation of lymphocyte migration (GO:2000401)2.35661519
92positive regulation of lipid kinase activity (GO:0090218)2.35157482
93defense response to protozoan (GO:0042832)2.34689073
94lymph node development (GO:0048535)2.34533884
95dendritic cell differentiation (GO:0097028)2.34379068
96regulation of macrophage chemotaxis (GO:0010758)2.32817233
97positive regulation of neutrophil migration (GO:1902624)2.32316772
98positive regulation of neutrophil chemotaxis (GO:0090023)2.32316772
99phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.31557680
100* complement activation, classical pathway (GO:0006958)10.6524633

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.30186689
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.89224776
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.59129791
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.12872403
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.25490003
6RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.17908839
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.60770455
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.55308013
9LXR_22292898_ChIP-Seq_THP-1_Human2.16264874
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.04540457
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02789478
12IRF8_27001747_Chip-Seq_BMDM_Mouse1.97329936
13RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90073949
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89194431
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.88003614
16CDX2_20551321_ChIP-Seq_CACO-2_Human1.84514770
17VDR_21846776_ChIP-Seq_THP-1_Human1.80511877
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78404720
19VDR_24763502_ChIP-Seq_THP-1_Human1.70893449
20STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70304045
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68577824
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.67987409
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66949070
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66849243
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.66750743
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66532812
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65062490
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63677943
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62481939
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61710162
31EGR1_19032775_ChIP-ChIP_M12_Human1.59164684
32CLOCK_20551151_ChIP-Seq_293T_Human1.58896305
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52739984
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.49937190
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44855229
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44742206
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.41914514
38RACK7_27058665_Chip-Seq_MCF-7_Human1.41089360
39MYC_22102868_ChIP-Seq_BL_Human1.35833082
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34226835
41P63_26484246_Chip-Seq_KERATINOCYTES_Human1.34060325
42MAF_26560356_Chip-Seq_TH1_Human1.33931350
43TCF7_22412390_ChIP-Seq_EML_Mouse1.33029430
44RUNX_20019798_ChIP-Seq_JUKART_Human1.32913184
45SOX2_20726797_ChIP-Seq_SW620_Human1.30421191
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28754789
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.28570111
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28522959
49PPARA_22158963_ChIP-Seq_LIVER_Mouse1.27980882
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.27755121
51RXR_22158963_ChIP-Seq_LIVER_Mouse1.25818647
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24440180
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20499607
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.19910222
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19730869
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19382536
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19121070
58UTX_26944678_Chip-Seq_JUKART_Human1.19023022
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18752809
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18627734
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17643419
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14801196
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13979457
64GATA1_19941826_ChIP-Seq_K562_Human1.12860463
65BCOR_27268052_Chip-Seq_Bcells_Human1.11164706
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10736603
67KDM2B_26808549_Chip-Seq_DND41_Human1.10699836
68MYB_26560356_Chip-Seq_TH2_Human1.10477311
69GATA4_25053715_ChIP-Seq_YYC3_Human1.10005063
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09301425
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09156565
72BCL6_27268052_Chip-Seq_Bcells_Human1.08588006
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07854121
74SPI1_23127762_ChIP-Seq_K562_Human1.06589402
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.06015795
76FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05173740
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.04503155
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03060403
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03024569
80LXR_22158963_ChIP-Seq_LIVER_Mouse1.02987761
81GATA6_25053715_ChIP-Seq_YYC3_Human1.01874876
82MYB_26560356_Chip-Seq_TH1_Human1.01544924
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00885818
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00193019
85BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99771276
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99496929
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98281917
88SA1_27219007_Chip-Seq_ERYTHROID_Human0.98208858
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96860625
90SA1_27219007_Chip-Seq_Bcells_Human0.95434120
91FOXO3_23340844_ChIP-Seq_DLD1_Human0.95233133
92SPI1_23547873_ChIP-Seq_NB4_Human0.93870938
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92780453
94RUNX1_27514584_Chip-Seq_MCF-7_Human0.92554244
95VDR_24787735_ChIP-Seq_THP-1_Human0.92543740
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92418350
97SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90874604
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.90499716
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89966906
100CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89558582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.22001209
2MP0003303_peritoneal_inflammation3.53251997
3MP0010234_abnormal_vibrissa_follicle3.38306052
4MP0001835_abnormal_antigen_presentation3.14576474
5MP0003436_decreased_susceptibility_to3.13449000
6MP0010155_abnormal_intestine_physiology2.94490235
7MP0001790_abnormal_immune_system2.85610727
8MP0005387_immune_system_phenotype2.85610727
9MP0000685_abnormal_immune_system2.59998210
10MP0005025_abnormal_response_to2.40119298
11MP0005275_abnormal_skin_tensile2.31658002
12MP0001800_abnormal_humoral_immune2.30743746
13MP0009785_altered_susceptibility_to2.23946181
14MP0002138_abnormal_hepatobiliary_system2.15669765
15MP0000465_gastrointestinal_hemorrhage2.12742550
16MP0005000_abnormal_immune_tolerance2.12159816
17MP0005671_abnormal_response_to2.11272377
18MP0002796_impaired_skin_barrier2.06808194
19MP0001873_stomach_inflammation2.05549095
20MP0002148_abnormal_hypersensitivity_rea2.04690691
21MP0001533_abnormal_skeleton_physiology2.03803622
22MP0004264_abnormal_extraembryonic_tissu2.01823824
23MP0005166_decreased_susceptibility_to2.00467573
24MP0003300_gastrointestinal_ulcer1.92041205
25MP0004858_abnormal_nervous_system1.88889756
26MP0003866_abnormal_defecation1.88766733
27MP0006082_CNS_inflammation1.86492217
28MP0004782_abnormal_surfactant_physiolog1.81237940
29MP0002452_abnormal_antigen_presenting1.80888324
30MP0004947_skin_inflammation1.80170402
31MP0002419_abnormal_innate_immunity1.76623484
32MP0010352_gastrointestinal_tract_polyps1.76356622
33MP0002166_altered_tumor_susceptibility1.70117647
34MP0004510_myositis1.69735737
35MP0009840_abnormal_foam_cell1.69388754
36MP0005360_urolithiasis1.66614148
37MP0002723_abnormal_immune_serum1.66442999
38MP0001819_abnormal_immune_cell1.63862585
39MP0003191_abnormal_cellular_cholesterol1.63710028
40MP0002420_abnormal_adaptive_immunity1.63137559
41MP0001845_abnormal_inflammatory_respons1.61389722
42MP0002139_abnormal_hepatobiliary_system1.59058049
43MP0008438_abnormal_cutaneous_collagen1.49035570
44MP0005409_darkened_coat_color1.46662100
45MP0002933_joint_inflammation1.43867583
46MP0001663_abnormal_digestive_system1.43092465
47MP0008004_abnormal_stomach_pH1.42423078
48MP0005023_abnormal_wound_healing1.31637698
49MP0009333_abnormal_splenocyte_physiolog1.29478112
50MP0003075_altered_response_to1.28298724
51MP0003183_abnormal_peptide_metabolism1.27450837
52MP0003279_aneurysm1.26914603
53MP0000604_amyloidosis1.26893618
54MP0003448_altered_tumor_morphology1.26782879
55MP0005310_abnormal_salivary_gland1.22082260
56MP0001666_abnormal_nutrient_absorption1.21475456
57MP0002006_tumorigenesis1.20375811
58MP0003763_abnormal_thymus_physiology1.19693768
59MP0000343_altered_response_to1.17636127
60MP0003453_abnormal_keratinocyte_physiol1.16398462
61MP0002998_abnormal_bone_remodeling1.14565622
62MP0000716_abnormal_immune_system1.13968685
63MP0005503_abnormal_tendon_morphology1.13304842
64MP0003329_amyloid_beta_deposits1.10767340
65MP0005381_digestive/alimentary_phenotyp1.07344576
66MP0000490_abnormal_crypts_of1.06458271
67MP0005058_abnormal_lysosome_morphology1.06191723
68MP0000477_abnormal_intestine_morphology1.04531759
69MP0005390_skeleton_phenotype1.04240719
70MP0009278_abnormal_bone_marrow1.02850583
71MP0000858_altered_metastatic_potential1.02793699
72MP0005464_abnormal_platelet_physiology1.01808573
73MP0003806_abnormal_nucleotide_metabolis1.00551021
74MP0003045_fibrosis1.00388675
75MP0008469_abnormal_protein_level1.00384983
76MP0001851_eye_inflammation0.99067764
77MP0002398_abnormal_bone_marrow0.98136520
78MP0001216_abnormal_epidermal_layer0.97405193
79MP0009379_abnormal_foot_pigmentation0.97198725
80MP0005451_abnormal_body_composition0.96068244
81MP0002405_respiratory_system_inflammati0.95641610
82MP0000249_abnormal_blood_vessel0.94433127
83MP0009764_decreased_sensitivity_to0.93292231
84MP0002876_abnormal_thyroid_physiology0.91631122
85MP0001958_emphysema0.91400930
86MP0001664_abnormal_digestion0.87633513
87MP0002429_abnormal_blood_cell0.87314498
88MP0008260_abnormal_autophagy0.85463548
89MP0000678_abnormal_parathyroid_gland0.83829794
90MP0005501_abnormal_skin_physiology0.82112962
91MP0000579_abnormal_nail_morphology0.80005590
92MP0005165_increased_susceptibility_to0.78301654
93MP0005085_abnormal_gallbladder_physiolo0.77310690
94MP0005164_abnormal_response_to0.77227588
95MP0003828_pulmonary_edema0.77075320
96MP0004019_abnormal_vitamin_homeostasis0.75813176
97MP0000681_abnormal_thyroid_gland0.74941734
98MP0002722_abnormal_immune_system0.74836093
99MP0002133_abnormal_respiratory_system0.74619068
100MP0005388_respiratory_system_phenotype0.74619068

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.46006806
2Malnutrition (HP:0004395)5.71222829
3Abnormality of complement system (HP:0005339)4.63574161
4Eczematoid dermatitis (HP:0000976)4.54295075
5Complement deficiency (HP:0004431)4.36739050
6Glomerulonephritis (HP:0000099)4.35267579
7Increased IgE level (HP:0003212)4.12652347
8Abnormality of macrophages (HP:0004311)3.87162503
9Gastrointestinal stroma tumor (HP:0100723)3.64818907
10Agammaglobulinemia (HP:0004432)3.57406744
11Recurrent bronchitis (HP:0002837)3.54343979
12Nephritis (HP:0000123)3.50380008
13Colitis (HP:0002583)3.44657126
14Vasculitis (HP:0002633)3.43420701
15Abnormality of the nasal mucosa (HP:0000433)3.37362148
16Emphysema (HP:0002097)3.14238725
17Spontaneous hematomas (HP:0007420)3.07893666
18Cellulitis (HP:0100658)3.04404018
19Meningitis (HP:0001287)2.96986040
20Recurrent bacterial skin infections (HP:0005406)2.96323419
21Prostate neoplasm (HP:0100787)2.90363876
22Premature loss of primary teeth (HP:0006323)2.88104372
23Chronic diarrhea (HP:0002028)2.85002901
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.83820140
25Alopecia of scalp (HP:0002293)2.83631847
26Abnormality of glutamine family amino acid metabolism (HP:0010902)2.81980751
27Inflammation of the large intestine (HP:0002037)2.81124587
28Chronic otitis media (HP:0000389)2.80733869
29Urticaria (HP:0001025)2.74530256
30Gastrointestinal inflammation (HP:0004386)2.69912565
31Osteomyelitis (HP:0002754)2.69751367
32Skin rash (HP:0000988)2.68005992
33Abnormality of small intestinal villus morphology (HP:0011472)2.65796006
34Villous atrophy (HP:0011473)2.65796006
35Recurrent abscess formation (HP:0002722)2.65726623
36Abnormality of B cell number (HP:0010975)2.63333838
37Gastrointestinal infarctions (HP:0005244)2.63199065
38Abnormality of cells of the lymphoid lineage (HP:0012140)2.59341832
39Abnormality of the prostate (HP:0008775)2.58585918
40Hemoptysis (HP:0002105)2.58236702
41Chronic obstructive pulmonary disease (HP:0006510)2.58069939
42Obstructive lung disease (HP:0006536)2.58069939
43Ankyloglossia (HP:0010296)2.55517806
44Abnormality of nail color (HP:0100643)2.55067374
45Myositis (HP:0100614)2.52157258
46Nasal polyposis (HP:0100582)2.52020673
47Orchitis (HP:0100796)2.51441301
48Mediastinal lymphadenopathy (HP:0100721)2.51276670
49Gingivitis (HP:0000230)2.51215652
50Recurrent viral infections (HP:0004429)2.45460754
51Pulmonary infiltrates (HP:0002113)2.43193128
52Fragile skin (HP:0001030)2.42202021
53Recurrent sinusitis (HP:0011108)2.38198143
54Purpura (HP:0000979)2.37211241
55Hypergammaglobulinemia (HP:0010702)2.32183286
56Recurrent gram-negative bacterial infections (HP:0005420)2.31555701
57Restrictive lung disease (HP:0002091)2.30033872
58Elevated erythrocyte sedimentation rate (HP:0003565)2.29829316
59Pustule (HP:0200039)2.28633246
60Palmoplantar hyperkeratosis (HP:0000972)2.26140318
61Recurrent skin infections (HP:0001581)2.21623670
62Atrophic scars (HP:0001075)2.20009311
63Recurrent fungal infections (HP:0002841)2.19767086
64Skin ulcer (HP:0200042)2.17384190
65Polycythemia (HP:0001901)2.13993091
66Right ventricular cardiomyopathy (HP:0011663)2.13239341
67B lymphocytopenia (HP:0010976)2.12841626
68Hematochezia (HP:0002573)2.12088598
69Leukocytosis (HP:0001974)2.11652591
70Hemorrhage of the eye (HP:0011885)2.11195760
71Palmar hyperkeratosis (HP:0010765)2.05960865
72Abnormality of monocarboxylic acid metabolism (HP:0010996)2.05497230
73Ileus (HP:0002595)2.03929331
74Recurrent lower respiratory tract infections (HP:0002783)2.03092225
75Chronic mucocutaneous candidiasis (HP:0002728)2.02593677
76Recurrent cutaneous fungal infections (HP:0011370)2.02593677
77Cheilitis (HP:0100825)2.01945560
78Recurrent pneumonia (HP:0006532)2.00692491
79Plantar hyperkeratosis (HP:0007556)2.00353228
80Verrucae (HP:0200043)1.99037091
81Papilloma (HP:0012740)1.99037091
82Thick nail (HP:0001805)1.98165010
83Bronchitis (HP:0012387)1.98110234
84Abnormality of the peritoneum (HP:0002585)1.97948338
85Milia (HP:0001056)1.97371280
86Abnormality of the pleura (HP:0002103)1.93082222
87Retrobulbar optic neuritis (HP:0100654)1.92893890
88Optic neuritis (HP:0100653)1.92893890
89Chest pain (HP:0100749)1.92084809
90Polygenic inheritance (HP:0010982)1.91580918
91Erythema (HP:0010783)1.91509986
92Panhypogammaglobulinemia (HP:0003139)1.91008535
93Gangrene (HP:0100758)1.90962299
94Interstitial pulmonary disease (HP:0006530)1.90348479
95Sepsis (HP:0100806)1.88377633
96Lymphopenia (HP:0001888)1.87228534
97Abnormality of oral frenula (HP:0000190)1.87224162
98Segmental peripheral demyelination/remyelination (HP:0003481)1.85667643
99Autoimmune thrombocytopenia (HP:0001973)1.84112540
100Thin bony cortex (HP:0002753)1.83849780

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.43699835
2TYK23.44579741
3MAP4K13.23482938
4FGFR43.05005170
5MST1R2.91465707
6RIPK12.61343886
7PRPF4B2.57126679
8BLK2.43531557
9CDC42BPA2.27527663
10EPHA32.25637346
11RIPK42.20056018
12KIT2.19289247
13JAK32.02748436
14EPHB11.98770619
15JAK11.96200664
16IKBKE1.82590078
17ZAP701.74892715
18FGFR31.69501378
19MAP3K141.63643018
20TBK11.61039366
21TRIB31.53478138
22GRK61.52924930
23TGFBR21.51374967
24CSK1.44634651
25DDR21.41907111
26PDGFRA1.39743656
27IRAK41.39229588
28MAP3K11.35414467
29TXK1.30415616
30FES1.29383969
31EPHB21.28574112
32EPHA21.26915783
33JAK21.24695966
34PRKG21.22661221
35MAP3K101.17628201
36PTK61.11973191
37FER1.11234665
38PKN21.08129951
39SYK1.07126629
40SMG11.06930294
41LYN1.04167543
42MAP3K131.01764086
43TAOK11.01438517
44MATK0.97691728
45MAP3K30.97090589
46MET0.96467688
47IRAK10.91080215
48BTK0.89911642
49ACVR1B0.88423287
50MAP3K110.87372056
51CSF1R0.81471924
52MAPK70.81019210
53IRAK30.80210033
54HCK0.79582448
55MAP3K60.78650775
56HIPK20.77963092
57IKBKB0.77401048
58MYLK0.76070005
59SIK30.75934281
60STK240.73859577
61PIK3CA0.73136054
62LCK0.70214467
63NLK0.68021382
64TESK20.63872523
65PDPK10.63467437
66TGFBR10.63388469
67RET0.62898696
68DMPK0.61377838
69KDR0.60595782
70TESK10.60026284
71MAP2K20.59285741
72FGR0.59098679
73MAP2K30.58690761
74BMX0.56330291
75FYN0.54598837
76PDGFRB0.54430571
77BMPR20.53038421
78LRRK20.52603399
79PRKD20.52158597
80MAPKAPK20.50613091
81TNK20.49817622
82SIK10.45962254
83MAP3K20.42365334
84YES10.42201010
85PDK10.39645950
86TAOK20.39136990
87MAPK110.38908922
88MAPK40.38503451
89GRK50.37356314
90ITK0.36625517
91SRC0.35222389
92MAP3K70.34710222
93ABL20.34469632
94PAK40.33224747
95CDK60.33022166
96PRKCD0.31306071
97KSR20.30533534
98IGF1R0.29995878
99RPS6KC10.27753452
100RPS6KL10.27753452

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.09240251
2Staphylococcus aureus infection_Homo sapiens_hsa051504.04775976
3Allograft rejection_Homo sapiens_hsa053303.49362652
4Autoimmune thyroid disease_Homo sapiens_hsa053203.34793815
5Graft-versus-host disease_Homo sapiens_hsa053323.29539974
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.08151682
7Type I diabetes mellitus_Homo sapiens_hsa049402.72945368
8Leishmaniasis_Homo sapiens_hsa051402.52710754
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.42915932
10Antigen processing and presentation_Homo sapiens_hsa046122.33530941
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30440497
12Viral myocarditis_Homo sapiens_hsa054162.08543921
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.84260887
14Pertussis_Homo sapiens_hsa051331.81076068
15Rheumatoid arthritis_Homo sapiens_hsa053231.68054894
16Fat digestion and absorption_Homo sapiens_hsa049751.67070349
17Toxoplasmosis_Homo sapiens_hsa051451.65119987
18Primary immunodeficiency_Homo sapiens_hsa053401.58944144
19Renin-angiotensin system_Homo sapiens_hsa046141.43292098
20Tuberculosis_Homo sapiens_hsa051521.41529828
21Hematopoietic cell lineage_Homo sapiens_hsa046401.40839893
22Arginine biosynthesis_Homo sapiens_hsa002201.39669432
23Influenza A_Homo sapiens_hsa051641.32737484
24Osteoclast differentiation_Homo sapiens_hsa043801.31682130
25Other glycan degradation_Homo sapiens_hsa005111.29757289
26Complement and coagulation cascades_Homo sapiens_hsa046101.25397049
27Fructose and mannose metabolism_Homo sapiens_hsa000511.22386520
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21489598
29Sulfur metabolism_Homo sapiens_hsa009201.16199159
30B cell receptor signaling pathway_Homo sapiens_hsa046621.14165456
31Systemic lupus erythematosus_Homo sapiens_hsa053221.12540278
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.11471083
33Herpes simplex infection_Homo sapiens_hsa051681.11216811
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10602290
35Malaria_Homo sapiens_hsa051441.09124131
36Protein digestion and absorption_Homo sapiens_hsa049741.08563297
37Phagosome_Homo sapiens_hsa041451.07816313
38TNF signaling pathway_Homo sapiens_hsa046681.06311758
39Chemokine signaling pathway_Homo sapiens_hsa040621.06075187
40Arachidonic acid metabolism_Homo sapiens_hsa005901.03670390
41Linoleic acid metabolism_Homo sapiens_hsa005910.93866652
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92998600
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90029169
44Hepatitis C_Homo sapiens_hsa051600.87900924
45African trypanosomiasis_Homo sapiens_hsa051430.87867942
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81026768
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.80418650
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79399631
49Mineral absorption_Homo sapiens_hsa049780.75044682
50Amoebiasis_Homo sapiens_hsa051460.74672842
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72877409
52Ether lipid metabolism_Homo sapiens_hsa005650.70335200
53Histidine metabolism_Homo sapiens_hsa003400.67615873
54Pancreatic secretion_Homo sapiens_hsa049720.66355601
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.64991982
56Prion diseases_Homo sapiens_hsa050200.64735223
57Measles_Homo sapiens_hsa051620.60114591
58Acute myeloid leukemia_Homo sapiens_hsa052210.58933567
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58142600
60Vitamin digestion and absorption_Homo sapiens_hsa049770.55574021
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54687699
62Lysosome_Homo sapiens_hsa041420.54378047
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53959126
64Salmonella infection_Homo sapiens_hsa051320.50668897
65Galactose metabolism_Homo sapiens_hsa000520.49720851
66PPAR signaling pathway_Homo sapiens_hsa033200.48683619
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48173604
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47823356
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46854296
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42766170
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42188415
72HTLV-I infection_Homo sapiens_hsa051660.40447435
73Apoptosis_Homo sapiens_hsa042100.40275351
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39210647
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38913316
76Glycerolipid metabolism_Homo sapiens_hsa005610.38587099
77Prolactin signaling pathway_Homo sapiens_hsa049170.35414420
78GnRH signaling pathway_Homo sapiens_hsa049120.35224927
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.34944690
80Caffeine metabolism_Homo sapiens_hsa002320.34647521
81Arginine and proline metabolism_Homo sapiens_hsa003300.34211940
82Epstein-Barr virus infection_Homo sapiens_hsa051690.33252893
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.33070892
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32289274
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.31325524
86Legionellosis_Homo sapiens_hsa051340.31129148
87Bladder cancer_Homo sapiens_hsa052190.30990124
88Hepatitis B_Homo sapiens_hsa051610.30922568
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.30511039
90Platelet activation_Homo sapiens_hsa046110.29952406
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.29650208
92Thyroid hormone synthesis_Homo sapiens_hsa049180.29252178
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29084850
94Fatty acid degradation_Homo sapiens_hsa000710.26709561
95VEGF signaling pathway_Homo sapiens_hsa043700.26436417
96Starch and sucrose metabolism_Homo sapiens_hsa005000.25593062
97Pancreatic cancer_Homo sapiens_hsa052120.23918728
98Retinol metabolism_Homo sapiens_hsa008300.23725275
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23539014
100T cell receptor signaling pathway_Homo sapiens_hsa046600.22511264

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