IGHG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* complement activation (GO:0006956)8.81475343
2positive regulation of respiratory burst (GO:0060267)7.80178353
3glomerular filtration (GO:0003094)7.32767966
4renal filtration (GO:0097205)6.66357965
5* protein activation cascade (GO:0072376)6.49017855
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.60326675
7regulation of dendritic cell antigen processing and presentation (GO:0002604)5.53884005
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.53339754
9regulation of cellular extravasation (GO:0002691)5.31571323
10antigen processing and presentation of endogenous antigen (GO:0019883)5.27555065
11regulation of respiratory burst (GO:0060263)5.23054400
12antimicrobial humoral response (GO:0019730)5.22801308
13antibacterial humoral response (GO:0019731)5.11381124
14* humoral immune response (GO:0006959)5.06317642
15* Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)4.93945262
16* immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00024.93945262
17* Fc-gamma receptor signaling pathway (GO:0038094)4.93945262
18* Fc receptor mediated stimulatory signaling pathway (GO:0002431)4.90885107
19angiotensin maturation (GO:0002003)4.54819826
20positive regulation of antigen processing and presentation (GO:0002579)4.53609769
21regulation of antigen processing and presentation (GO:0002577)4.29020052
22positive regulation of pseudopodium assembly (GO:0031274)4.27797267
23retina homeostasis (GO:0001895)3.85149764
24regulation of pseudopodium assembly (GO:0031272)3.84267688
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.75811998
26positive regulation of Cdc42 GTPase activity (GO:0043089)3.68801374
27interferon-gamma-mediated signaling pathway (GO:0060333)3.65990667
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.62539896
29immunoglobulin mediated immune response (GO:0016064)3.62516344
30detection of bacterium (GO:0016045)3.53654954
31germinal center formation (GO:0002467)3.46538085
32virion attachment to host cell (GO:0019062)3.43205925
33adhesion of symbiont to host cell (GO:0044650)3.43205925
34detection of other organism (GO:0098543)3.39108934
35dendritic cell chemotaxis (GO:0002407)3.29115091
36response to type I interferon (GO:0034340)3.17332824
37positive regulation of granulocyte chemotaxis (GO:0071624)3.16292482
38type I interferon signaling pathway (GO:0060337)3.15995471
39cellular response to type I interferon (GO:0071357)3.15995471
40chronic inflammatory response (GO:0002544)3.09431482
41peptide catabolic process (GO:0043171)3.09156887
42* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.06857054
43surfactant homeostasis (GO:0043129)3.05848905
44positive regulation of T cell migration (GO:2000406)3.03279776
45regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.02639748
46positive regulation of glycoprotein biosynthetic process (GO:0010560)3.01840390
47regulation of integrin activation (GO:0033623)3.01776133
48keratinization (GO:0031424)3.01683530
49regulation of T cell migration (GO:2000404)2.98480978
50cellular response to interferon-gamma (GO:0071346)2.98225083
51negative regulation of cell killing (GO:0031342)2.91080129
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.91080129
53adhesion of symbiont to host (GO:0044406)2.86350258
54response to interferon-gamma (GO:0034341)2.84954831
55positive regulation of glycoprotein metabolic process (GO:1903020)2.83238437
56positive regulation of neutrophil migration (GO:1902624)2.82205276
57positive regulation of neutrophil chemotaxis (GO:0090023)2.82205276
58positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.81923514
59regulation of glucose import in response to insulin stimulus (GO:2001273)2.77745106
60establishment of skin barrier (GO:0061436)2.75786110
61regulation of water loss via skin (GO:0033561)2.75667328
62positive regulation of lipid kinase activity (GO:0090218)2.72782042
63eosinophil chemotaxis (GO:0048245)2.71782867
64regulation of T cell tolerance induction (GO:0002664)2.68095838
65T-helper 1 type immune response (GO:0042088)2.67489420
66positive regulation of lymphocyte migration (GO:2000403)2.64795906
67positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.63752816
68dendritic cell migration (GO:0036336)2.63559080
69B cell mediated immunity (GO:0019724)2.61348625
70NIK/NF-kappaB signaling (GO:0038061)2.60463865
71endothelial cell chemotaxis (GO:0035767)2.58449613
72positive regulation of cell adhesion mediated by integrin (GO:0033630)2.58321772
73desmosome organization (GO:0002934)2.58023375
74T cell costimulation (GO:0031295)2.57358738
75myeloid dendritic cell differentiation (GO:0043011)2.55293814
76lymphocyte costimulation (GO:0031294)2.53439251
77regulation of monocyte chemotaxis (GO:0090025)2.50703698
78detection of external biotic stimulus (GO:0098581)2.49696435
79peptide cross-linking (GO:0018149)2.49314705
80response to prostaglandin E (GO:0034695)2.49186653
81regulation of T-helper 1 cell differentiation (GO:0045625)2.49136260
82response to nitric oxide (GO:0071731)2.47018257
83eosinophil migration (GO:0072677)2.46662598
84maintenance of gastrointestinal epithelium (GO:0030277)2.45923747
85regulation of guanylate cyclase activity (GO:0031282)2.45446397
86regulation of regulatory T cell differentiation (GO:0045589)2.43910258
87regulation of lymphocyte migration (GO:2000401)2.41067875
88regulation of necrotic cell death (GO:0010939)2.40367653
89interferon-gamma secretion (GO:0072643)2.39452892
90phosphatidylserine acyl-chain remodeling (GO:0036150)2.39060398
91positive regulation of gamma-delta T cell activation (GO:0046645)2.38843343
92* activation of immune response (GO:0002253)2.38816204
93regulation of vitamin metabolic process (GO:0030656)2.37256406
94keratinocyte differentiation (GO:0030216)2.37083974
95regulation of granulocyte chemotaxis (GO:0071622)2.36779000
96* immune response-activating signal transduction (GO:0002757)2.32761240
97antigen processing and presentation via MHC class Ib (GO:0002475)2.32368310
98intestinal absorption (GO:0050892)2.32207610
99multicellular organismal water homeostasis (GO:0050891)2.31085320
100* complement activation, classical pathway (GO:0006958)11.1644194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.19238702
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.05027067
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.54966970
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.52329309
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.08020811
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.86057744
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.55319681
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.41937987
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.39714515
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04928239
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.01144469
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94508499
13LXR_22292898_ChIP-Seq_THP-1_Human1.89459519
14IRF8_27001747_Chip-Seq_BMDM_Mouse1.89102296
15CLOCK_20551151_ChIP-Seq_293T_Human1.83734467
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83143973
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80804694
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80721471
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78868650
20SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71327174
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71009554
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68727153
23BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.67656521
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67294918
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59318648
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.58773545
27EGR1_19032775_ChIP-ChIP_M12_Human1.58581237
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56000999
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.53687274
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.49965565
31SOX2_20726797_ChIP-Seq_SW620_Human1.49091570
32P63_26484246_Chip-Seq_KERATINOCYTES_Human1.47327236
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46277075
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45862605
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42674314
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42184435
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.42102613
38VDR_24763502_ChIP-Seq_THP-1_Human1.39921801
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39761561
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39529118
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.38167298
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.37459972
43RACK7_27058665_Chip-Seq_MCF-7_Human1.31846878
44VDR_21846776_ChIP-Seq_THP-1_Human1.29296181
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.26688438
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26357074
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25342471
48GATA4_25053715_ChIP-Seq_YYC3_Human1.25334580
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22141286
50RUNX_20019798_ChIP-Seq_JUKART_Human1.21996933
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20656209
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19791734
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19153416
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19149746
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16698790
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15013218
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14667404
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13175719
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.13042046
60TCF7_22412390_ChIP-Seq_EML_Mouse1.12287740
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.11994806
62GATA6_25053715_ChIP-Seq_YYC3_Human1.10676171
63LXR_22158963_ChIP-Seq_LIVER_Mouse1.08952921
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07664161
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.07254236
66PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07191112
67MAF_26560356_Chip-Seq_TH1_Human1.07085962
68MYC_22102868_ChIP-Seq_BL_Human1.06680638
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06462427
70GATA1_19941826_ChIP-Seq_K562_Human1.04484922
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03390745
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03371127
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03206615
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02947018
75MYB_26560356_Chip-Seq_TH2_Human0.99092895
76RUNX1_27514584_Chip-Seq_MCF-7_Human0.99066144
77BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98249215
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96773695
79EGR1_19374776_ChIP-ChIP_THP-1_Human0.96435675
80UTX_26944678_Chip-Seq_JUKART_Human0.95325676
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94954884
82VDR_24787735_ChIP-Seq_THP-1_Human0.94928202
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94811550
84GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94368275
85BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93625934
86SPI1_23127762_ChIP-Seq_K562_Human0.92830998
87BCOR_27268052_Chip-Seq_Bcells_Human0.91520165
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91146727
89KDM2B_26808549_Chip-Seq_DND41_Human0.89524581
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89269653
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88982041
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88391928
93BCL6_27268052_Chip-Seq_Bcells_Human0.88190306
94MYB_26560356_Chip-Seq_TH1_Human0.87882744
95PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86985016
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86726243
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85802592
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83713241
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82951778
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82951778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.93329633
2MP0010234_abnormal_vibrissa_follicle3.89802231
3MP0005275_abnormal_skin_tensile3.16756945
4MP0003303_peritoneal_inflammation3.02578180
5MP0010155_abnormal_intestine_physiology2.86164650
6MP0001835_abnormal_antigen_presentation2.79837527
7MP0003436_decreased_susceptibility_to2.78497045
8MP0001790_abnormal_immune_system2.54064635
9MP0005387_immune_system_phenotype2.54064635
10MP0000685_abnormal_immune_system2.35979134
11MP0004264_abnormal_extraembryonic_tissu2.32578436
12MP0002796_impaired_skin_barrier2.24450688
13MP0008438_abnormal_cutaneous_collagen2.22647440
14MP0001800_abnormal_humoral_immune2.14509145
15MP0005025_abnormal_response_to2.13034594
16MP0009785_altered_susceptibility_to2.04270972
17MP0000465_gastrointestinal_hemorrhage2.02591818
18MP0005360_urolithiasis2.02251934
19MP0005503_abnormal_tendon_morphology1.98233686
20MP0004782_abnormal_surfactant_physiolog1.96545328
21MP0005409_darkened_coat_color1.95853707
22MP0005166_decreased_susceptibility_to1.92866428
23MP0001873_stomach_inflammation1.90402944
24MP0001533_abnormal_skeleton_physiology1.90222436
25MP0003300_gastrointestinal_ulcer1.87085205
26MP0005000_abnormal_immune_tolerance1.84304409
27MP0010352_gastrointestinal_tract_polyps1.83493969
28MP0005671_abnormal_response_to1.78234274
29MP0003866_abnormal_defecation1.78146563
30MP0002148_abnormal_hypersensitivity_rea1.77722827
31MP0004858_abnormal_nervous_system1.76555393
32MP0004947_skin_inflammation1.70450289
33MP0002452_abnormal_antigen_presenting1.67431623
34MP0009840_abnormal_foam_cell1.64193826
35MP0006082_CNS_inflammation1.64092683
36MP0002166_altered_tumor_susceptibility1.63875677
37MP0005023_abnormal_wound_healing1.55197167
38MP0002138_abnormal_hepatobiliary_system1.53485979
39MP0002723_abnormal_immune_serum1.52274130
40MP0002419_abnormal_innate_immunity1.52002081
41MP0001845_abnormal_inflammatory_respons1.48455883
42MP0003191_abnormal_cellular_cholesterol1.47961743
43MP0001819_abnormal_immune_cell1.46273945
44MP0003279_aneurysm1.46053308
45MP0002420_abnormal_adaptive_immunity1.44947280
46MP0003448_altered_tumor_morphology1.44691063
47MP0001666_abnormal_nutrient_absorption1.42910878
48MP0003183_abnormal_peptide_metabolism1.42898272
49MP0003453_abnormal_keratinocyte_physiol1.34988513
50MP0002933_joint_inflammation1.33365825
51MP0002139_abnormal_hepatobiliary_system1.32686320
52MP0001663_abnormal_digestive_system1.25339828
53MP0003075_altered_response_to1.23883700
54MP0008004_abnormal_stomach_pH1.22768604
55MP0009333_abnormal_splenocyte_physiolog1.19546781
56MP0002006_tumorigenesis1.18803168
57MP0000678_abnormal_parathyroid_gland1.15946728
58MP0000604_amyloidosis1.15290692
59MP0001958_emphysema1.13603294
60MP0010678_abnormal_skin_adnexa1.13119968
61MP0001216_abnormal_epidermal_layer1.11877308
62MP0002998_abnormal_bone_remodeling1.10859421
63MP0000343_altered_response_to1.10473865
64MP0000579_abnormal_nail_morphology1.08879831
65MP0003045_fibrosis1.07689562
66MP0003763_abnormal_thymus_physiology1.07628401
67MP0005390_skeleton_phenotype1.06840193
68MP0000858_altered_metastatic_potential1.05044035
69MP0005310_abnormal_salivary_gland1.04849409
70MP0000716_abnormal_immune_system1.03505660
71MP0009379_abnormal_foot_pigmentation1.02832292
72MP0004019_abnormal_vitamin_homeostasis1.02472957
73MP0004510_myositis1.02464340
74MP0001851_eye_inflammation1.02351494
75MP0000477_abnormal_intestine_morphology1.02270135
76MP0003566_abnormal_cell_adhesion1.01193667
77MP0000249_abnormal_blood_vessel0.99229198
78MP0000490_abnormal_crypts_of0.94811562
79MP0002098_abnormal_vibrissa_morphology0.94565978
80MP0005381_digestive/alimentary_phenotyp0.94429304
81MP0005058_abnormal_lysosome_morphology0.94207495
82MP0009764_decreased_sensitivity_to0.93891282
83MP0002060_abnormal_skin_morphology0.92825899
84MP0008469_abnormal_protein_level0.92098710
85MP0003329_amyloid_beta_deposits0.91892608
86MP0000681_abnormal_thyroid_gland0.90802167
87MP0005501_abnormal_skin_physiology0.89724484
88MP0005164_abnormal_response_to0.89351134
89MP0005085_abnormal_gallbladder_physiolo0.88024284
90MP0002405_respiratory_system_inflammati0.86917533
91MP0005464_abnormal_platelet_physiology0.86746085
92MP0003091_abnormal_cell_migration0.85185484
93MP0003828_pulmonary_edema0.85098094
94MP0008260_abnormal_autophagy0.84413516
95MP0001879_abnormal_lymphatic_vessel0.84405882
96MP0002398_abnormal_bone_marrow0.84162303
97MP0001664_abnormal_digestion0.82984795
98MP0002133_abnormal_respiratory_system0.82789133
99MP0005388_respiratory_system_phenotype0.82789133
100MP0002896_abnormal_bone_mineralization0.81913857

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.62673123
2Malnutrition (HP:0004395)5.46880177
3Abnormality of complement system (HP:0005339)4.85938977
4Complement deficiency (HP:0004431)4.61494006
5Glomerulonephritis (HP:0000099)4.56358539
6Alopecia of scalp (HP:0002293)4.35593209
7Eczematoid dermatitis (HP:0000976)4.10924288
8Increased IgE level (HP:0003212)3.86251447
9Nephritis (HP:0000123)3.70596701
10Abnormality of macrophages (HP:0004311)3.55442104
11Recurrent bronchitis (HP:0002837)3.27231681
12Prostate neoplasm (HP:0100787)3.22452002
13Gastrointestinal stroma tumor (HP:0100723)3.17509968
14Vasculitis (HP:0002633)3.16464603
15Thick nail (HP:0001805)3.04417499
16Abnormality of glutamine family amino acid metabolism (HP:0010902)3.00474906
17Abnormality of the nasal mucosa (HP:0000433)2.98788695
18Emphysema (HP:0002097)2.98065957
19Agammaglobulinemia (HP:0004432)2.93538772
20Premature loss of primary teeth (HP:0006323)2.88478906
21Abnormality of nail color (HP:0100643)2.87327278
22Right ventricular cardiomyopathy (HP:0011663)2.80113946
23Colitis (HP:0002583)2.78732484
24Chronic diarrhea (HP:0002028)2.75194855
25Palmoplantar hyperkeratosis (HP:0000972)2.73160087
26Spontaneous hematomas (HP:0007420)2.73024619
27Villous atrophy (HP:0011473)2.67836076
28Abnormality of small intestinal villus morphology (HP:0011472)2.67836076
29Gastrointestinal infarctions (HP:0005244)2.67010139
30Recurrent bacterial skin infections (HP:0005406)2.64840294
31Abnormality of the prostate (HP:0008775)2.63772244
32Gingivitis (HP:0000230)2.60935823
33Atrophic scars (HP:0001075)2.56882467
34Chronic otitis media (HP:0000389)2.55426069
35Cellulitis (HP:0100658)2.53166525
36Skin rash (HP:0000988)2.52338831
37Palmar hyperkeratosis (HP:0010765)2.51166152
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.48797830
39Fragile skin (HP:0001030)2.46966498
40Meningitis (HP:0001287)2.45317236
41Hemoptysis (HP:0002105)2.44787303
42Urticaria (HP:0001025)2.43334682
43Plantar hyperkeratosis (HP:0007556)2.39039103
44Abnormal hair laboratory examination (HP:0003328)2.36529960
45Osteomyelitis (HP:0002754)2.32883361
46Pustule (HP:0200039)2.32286426
47Abnormality of cells of the lymphoid lineage (HP:0012140)2.31395183
48Inflammation of the large intestine (HP:0002037)2.29955089
49Recurrent abscess formation (HP:0002722)2.29238298
50Nasal polyposis (HP:0100582)2.26878579
51Interstitial pulmonary disease (HP:0006530)2.23231681
52Osteolytic defects of the hand bones (HP:0009699)2.22739787
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.22739787
54Hypergammaglobulinemia (HP:0010702)2.22150429
55Protrusio acetabuli (HP:0003179)2.22001475
56Gastrointestinal inflammation (HP:0004386)2.20081454
57Cerebral aneurysm (HP:0004944)2.19202461
58Pulmonary infiltrates (HP:0002113)2.15111617
59Myositis (HP:0100614)2.13039124
60Ileus (HP:0002595)2.12087032
61Restrictive lung disease (HP:0002091)2.11206663
62Skin ulcer (HP:0200042)2.10198089
63Chronic obstructive pulmonary disease (HP:0006510)2.09425063
64Obstructive lung disease (HP:0006536)2.09425063
65Orchitis (HP:0100796)2.08028188
66Ankyloglossia (HP:0010296)2.07890356
67Purpura (HP:0000979)2.05305062
68Pili torti (HP:0003777)2.04829833
69Erythema (HP:0010783)2.03888708
70Recurrent viral infections (HP:0004429)2.02682203
71Aortic dissection (HP:0002647)2.02550279
72Mediastinal lymphadenopathy (HP:0100721)2.00572461
73Abnormality of monocarboxylic acid metabolism (HP:0010996)2.00502436
74Milia (HP:0001056)2.00339761
75Leukocytosis (HP:0001974)2.00303943
76Metaphyseal cupping (HP:0003021)2.00020625
77Abnormality of the axillary hair (HP:0100134)1.99759116
78Abnormality of secondary sexual hair (HP:0009888)1.99759116
79Xerostomia (HP:0000217)1.98912460
80Recurrent gram-negative bacterial infections (HP:0005420)1.98894013
81Elevated erythrocyte sedimentation rate (HP:0003565)1.95509042
82Abnormality of B cell number (HP:0010975)1.94307033
83Segmental peripheral demyelination/remyelination (HP:0003481)1.94291291
84Follicular hyperkeratosis (HP:0007502)1.94107693
85Recurrent skin infections (HP:0001581)1.93056514
86Thin bony cortex (HP:0002753)1.92713254
87Abnormality of the peritoneum (HP:0002585)1.90050491
88Peritonitis (HP:0002586)1.87110881
89Recurrent fungal infections (HP:0002841)1.85652403
90Hematochezia (HP:0002573)1.83346948
91Cervical subluxation (HP:0003308)1.83015755
92Polygenic inheritance (HP:0010982)1.82360620
93Hemorrhage of the eye (HP:0011885)1.80667893
94Blepharitis (HP:0000498)1.80471373
95Premature rupture of membranes (HP:0001788)1.80216815
96Neoplasm of the lung (HP:0100526)1.80123881
97Abnormal blistering of the skin (HP:0008066)1.78016162
98Bronchitis (HP:0012387)1.77052752
99Abnormality of the pleura (HP:0002103)1.74647788
100Polycythemia (HP:0001901)1.72942820

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.08453191
2TYK23.44767471
3FGFR43.31389961
4MST1R3.22201822
5MAP4K12.87937499
6RIPK12.79707018
7EPHA32.46878163
8BLK2.44848102
9CDC42BPA2.23281181
10KIT2.22957378
11PRPF4B2.18464800
12EPHB12.02014302
13JAK12.00263185
14JAK31.96108303
15FGFR31.90592337
16RIPK41.78307206
17PDGFRA1.74275272
18IKBKE1.70610849
19MAP3K141.55478651
20TGFBR11.54912126
21ZAP701.54042357
22TBK11.52291746
23TRIB31.51402756
24TGFBR21.39264616
25PKN21.37706372
26ACVR1B1.37366939
27FER1.33744370
28MET1.32908591
29GRK61.31914386
30MAP3K11.29281184
31DDR21.28915460
32EPHB21.25491295
33CSK1.24778277
34PRKG21.23261772
35EPHA21.22746032
36MAP3K101.16217101
37IRAK41.10302596
38MYLK1.09851546
39JAK21.09764815
40FES1.09727499
41TXK1.08001017
42STK241.07648098
43PTK61.06177232
44IRAK10.98739175
45DMPK0.96166431
46LYN0.92374051
47MAP3K60.92151672
48MAP3K130.92079095
49PAK40.91453196
50SYK0.89563655
51MATK0.85734049
52SIK30.85137737
53MAPK70.84635519
54NLK0.81530370
55CSF1R0.81129182
56TAOK10.80236413
57MAP3K30.78935454
58KDR0.78593496
59IKBKB0.75726021
60BTK0.75613869
61HIPK20.75283531
62RET0.70300627
63PDGFRB0.69177394
64HCK0.68807548
65TESK10.67422639
66IRAK30.65173257
67PIK3CA0.63324497
68LCK0.61810176
69BMX0.61213643
70SMG10.60899258
71LRRK20.58894817
72BMPR20.58604066
73MAP3K20.57565931
74PDPK10.55858761
75MAP3K110.52590417
76FYN0.51627676
77MAPKAPK20.49745255
78PRKD20.49510741
79SIK10.48817779
80FGR0.48792020
81FLT30.47010294
82MAP2K20.46984778
83MAPKAPK30.44528815
84YES10.44153961
85TESK20.42126105
86CDK60.41841337
87MAPK110.41725756
88MAP2K60.40002199
89ITK0.38899275
90MAP3K70.38258930
91PDK20.37115220
92SRC0.35519914
93MAP3K120.35390376
94IGF1R0.34989966
95PTK20.34776687
96PDK10.32556910
97ABL10.29746535
98PRKCD0.28783321
99PRKD10.27917067
100KSR20.27710599

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.98911110
2Asthma_Homo sapiens_hsa053103.88335909
3Allograft rejection_Homo sapiens_hsa053303.29254732
4Autoimmune thyroid disease_Homo sapiens_hsa053203.20849267
5Graft-versus-host disease_Homo sapiens_hsa053323.07572835
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.92120285
7Type I diabetes mellitus_Homo sapiens_hsa049402.52599261
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.42120348
9Leishmaniasis_Homo sapiens_hsa051402.37054686
10Antigen processing and presentation_Homo sapiens_hsa046122.25357866
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.23286705
12Viral myocarditis_Homo sapiens_hsa054161.92692240
13Pertussis_Homo sapiens_hsa051331.83446107
14Renin-angiotensin system_Homo sapiens_hsa046141.82999488
15Fat digestion and absorption_Homo sapiens_hsa049751.77332581
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64986793
17Toxoplasmosis_Homo sapiens_hsa051451.60934303
18Rheumatoid arthritis_Homo sapiens_hsa053231.44039825
19Complement and coagulation cascades_Homo sapiens_hsa046101.42449536
20Protein digestion and absorption_Homo sapiens_hsa049741.42352352
21Primary immunodeficiency_Homo sapiens_hsa053401.35634818
22Arginine biosynthesis_Homo sapiens_hsa002201.33380196
23Hematopoietic cell lineage_Homo sapiens_hsa046401.33044330
24Tuberculosis_Homo sapiens_hsa051521.32544795
25Influenza A_Homo sapiens_hsa051641.30655166
26Other glycan degradation_Homo sapiens_hsa005111.28537849
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20586389
28Fructose and mannose metabolism_Homo sapiens_hsa000511.19117739
29Osteoclast differentiation_Homo sapiens_hsa043801.15874859
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.14219401
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12906799
32Phagosome_Homo sapiens_hsa041451.12529595
33Arachidonic acid metabolism_Homo sapiens_hsa005901.06948292
34Chemokine signaling pathway_Homo sapiens_hsa040621.03824976
35B cell receptor signaling pathway_Homo sapiens_hsa046621.03059811
36Sulfur metabolism_Homo sapiens_hsa009201.02275428
37Herpes simplex infection_Homo sapiens_hsa051681.02188350
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01701661
39Linoleic acid metabolism_Homo sapiens_hsa005910.99710523
40Malaria_Homo sapiens_hsa051440.94927200
41TNF signaling pathway_Homo sapiens_hsa046680.93679498
42Mineral absorption_Homo sapiens_hsa049780.93027865
43Histidine metabolism_Homo sapiens_hsa003400.92647441
44Vitamin digestion and absorption_Homo sapiens_hsa049770.90328793
45Amoebiasis_Homo sapiens_hsa051460.88369712
46Hepatitis C_Homo sapiens_hsa051600.87899972
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87531300
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.84397976
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79201296
50Ether lipid metabolism_Homo sapiens_hsa005650.72159706
51African trypanosomiasis_Homo sapiens_hsa051430.71284937
52Pancreatic secretion_Homo sapiens_hsa049720.71118196
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70529014
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65984042
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65883892
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65578384
57Prion diseases_Homo sapiens_hsa050200.61534396
58Systemic lupus erythematosus_Homo sapiens_hsa053220.60692715
59Measles_Homo sapiens_hsa051620.59097149
60Lysosome_Homo sapiens_hsa041420.58482197
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.57388601
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.56221380
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53993926
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53570573
65PPAR signaling pathway_Homo sapiens_hsa033200.53310421
66Starch and sucrose metabolism_Homo sapiens_hsa005000.51810152
67Galactose metabolism_Homo sapiens_hsa000520.51476973
68Acute myeloid leukemia_Homo sapiens_hsa052210.50787231
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50249200
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47912681
71Caffeine metabolism_Homo sapiens_hsa002320.46247962
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45438716
73Retinol metabolism_Homo sapiens_hsa008300.44877297
74Salmonella infection_Homo sapiens_hsa051320.42744856
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41326695
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.40900093
77GnRH signaling pathway_Homo sapiens_hsa049120.40756682
78Thyroid hormone synthesis_Homo sapiens_hsa049180.40344193
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40227613
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39417712
81Notch signaling pathway_Homo sapiens_hsa043300.37675579
82Chemical carcinogenesis_Homo sapiens_hsa052040.37308489
83Platelet activation_Homo sapiens_hsa046110.37072544
84Arginine and proline metabolism_Homo sapiens_hsa003300.37053656
85Glycerolipid metabolism_Homo sapiens_hsa005610.36471397
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35932843
87Apoptosis_Homo sapiens_hsa042100.35905691
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35527113
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35510148
90HTLV-I infection_Homo sapiens_hsa051660.35488512
91Prolactin signaling pathway_Homo sapiens_hsa049170.34967702
92Renin secretion_Homo sapiens_hsa049240.34342287
93Pancreatic cancer_Homo sapiens_hsa052120.32461764
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31794316
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31531414
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.30848987
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30777176
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.30678318
99Hepatitis B_Homo sapiens_hsa051610.28050319
100VEGF signaling pathway_Homo sapiens_hsa043700.27926682

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