IGHGP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of respiratory burst (GO:0060267)8.78441630
2complement activation (GO:0006956)8.35739320
3glomerular filtration (GO:0003094)7.19844706
4renal filtration (GO:0097205)6.49994564
5protein activation cascade (GO:0072376)6.11646012
6antimicrobial humoral response (GO:0019730)6.08701269
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.05865476
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.01214586
9antibacterial humoral response (GO:0019731)5.99866271
10regulation of respiratory burst (GO:0060263)5.94053916
11antigen processing and presentation of endogenous antigen (GO:0019883)5.71163429
12regulation of dendritic cell antigen processing and presentation (GO:0002604)5.64734463
13regulation of cellular extravasation (GO:0002691)5.60983540
14humoral immune response (GO:0006959)5.13582126
15positive regulation of pseudopodium assembly (GO:0031274)5.02864297
16Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)4.92539019
17immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00024.92539019
18Fc-gamma receptor signaling pathway (GO:0038094)4.92539019
19Fc receptor mediated stimulatory signaling pathway (GO:0002431)4.89989815
20angiotensin maturation (GO:0002003)4.72853422
21regulation of pseudopodium assembly (GO:0031272)4.51741463
22positive regulation of antigen processing and presentation (GO:0002579)4.50095555
23regulation of antigen processing and presentation (GO:0002577)4.37861338
24immunoglobulin mediated immune response (GO:0016064)4.16435342
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.15611865
26retina homeostasis (GO:0001895)4.11456301
27positive regulation of Cdc42 GTPase activity (GO:0043089)3.98373000
28detection of bacterium (GO:0016045)3.88621757
29regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.79459418
30interferon-gamma-mediated signaling pathway (GO:0060333)3.71849597
31detection of other organism (GO:0098543)3.69695197
32regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.62645217
33chronic inflammatory response (GO:0002544)3.53078268
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.52212808
35negative regulation of cell killing (GO:0031342)3.52212808
36germinal center formation (GO:0002467)3.45689080
37eosinophil chemotaxis (GO:0048245)3.33072256
38dendritic cell chemotaxis (GO:0002407)3.26823836
39GDP-mannose metabolic process (GO:0019673)3.21337939
40regulation of guanylate cyclase activity (GO:0031282)3.19732870
41type I interferon signaling pathway (GO:0060337)3.19530884
42cellular response to type I interferon (GO:0071357)3.19530884
43response to type I interferon (GO:0034340)3.18585594
44regulation of integrin activation (GO:0033623)3.17865558
45immune response-activating cell surface receptor signaling pathway (GO:0002429)3.17609120
46positive regulation of granulocyte chemotaxis (GO:0071624)3.15383022
47positive regulation of glycoprotein biosynthetic process (GO:0010560)3.12261156
48positive regulation of T cell migration (GO:2000406)3.11962407
49B cell mediated immunity (GO:0019724)3.08329620
50cellular response to interferon-gamma (GO:0071346)3.06842685
51T-helper 1 type immune response (GO:0042088)3.02268606
52regulation of T cell migration (GO:2000404)3.02051679
53eosinophil migration (GO:0072677)3.01010390
54NIK/NF-kappaB signaling (GO:0038061)2.99753952
55myeloid dendritic cell differentiation (GO:0043011)2.98342262
56positive regulation of glycoprotein metabolic process (GO:1903020)2.98259494
57intestinal absorption (GO:0050892)2.96725855
58regulation of glucose import in response to insulin stimulus (GO:2001273)2.94728558
59peptide catabolic process (GO:0043171)2.93611233
60response to interferon-gamma (GO:0034341)2.93396158
61maintenance of gastrointestinal epithelium (GO:0030277)2.92907039
62adhesion of symbiont to host cell (GO:0044650)2.86179741
63virion attachment to host cell (GO:0019062)2.86179741
64positive regulation of neutrophil chemotaxis (GO:0090023)2.82035142
65positive regulation of neutrophil migration (GO:1902624)2.82035142
66positive regulation of lymphocyte migration (GO:2000403)2.76122962
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.74829080
68regulation of T-helper 1 cell differentiation (GO:0045625)2.71164606
69defense response to Gram-negative bacterium (GO:0050829)2.70136789
70regulation of T cell tolerance induction (GO:0002664)2.68591692
71T cell costimulation (GO:0031295)2.68528415
72regulation of monocyte chemotaxis (GO:0090025)2.67954175
73detection of external biotic stimulus (GO:0098581)2.67345511
74negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.67245217
75myeloid dendritic cell activation (GO:0001773)2.67140633
76phosphatidylserine acyl-chain remodeling (GO:0036150)2.65903860
77lymphocyte costimulation (GO:0031294)2.64370991
78positive regulation of lipid kinase activity (GO:0090218)2.63600986
79production of molecular mediator of immune response (GO:0002440)2.62931399
80dendritic cell migration (GO:0036336)2.59610714
81phosphatidylinositol acyl-chain remodeling (GO:0036149)2.59525958
82positive regulation of gamma-delta T cell activation (GO:0046645)2.58044860
83regulation of vitamin metabolic process (GO:0030656)2.57522748
84arginine catabolic process (GO:0006527)2.57049541
85positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.55415436
86regulation of necrotic cell death (GO:0010939)2.50093458
87keratinization (GO:0031424)2.48424164
88positive regulation of guanylate cyclase activity (GO:0031284)2.47763906
89regulation of systemic arterial blood pressure by hormone (GO:0001990)2.47093535
90regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.47093535
91endocrine process (GO:0050886)2.47093535
92regulation of lymphocyte migration (GO:2000401)2.45610881
93antigen processing and presentation via MHC class Ib (GO:0002475)2.45467241
94response to prostaglandin E (GO:0034695)2.45026846
95phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.44961959
96protein-chromophore linkage (GO:0018298)2.44107256
97response to nitric oxide (GO:0071731)2.42832994
98dendritic cell differentiation (GO:0097028)2.42726763
99NADH metabolic process (GO:0006734)2.42535048
100complement activation, classical pathway (GO:0006958)10.5695064

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.14673904
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.80861220
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.49071230
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.15200042
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.18316904
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.87685808
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.76463477
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.57539004
9LXR_22292898_ChIP-Seq_THP-1_Human2.33899362
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.19731414
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.19162543
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.00468562
13VDR_21846776_ChIP-Seq_THP-1_Human1.88760868
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85709763
15IRF8_27001747_Chip-Seq_BMDM_Mouse1.84887278
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81959575
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80106445
18VDR_24763502_ChIP-Seq_THP-1_Human1.74580767
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73403869
20SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72286460
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.68986536
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67366433
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.64634857
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.64624854
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63512185
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61559146
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59496961
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58671961
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57671174
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57383771
31EGR1_19032775_ChIP-ChIP_M12_Human1.56804281
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.53222708
33RACK7_27058665_Chip-Seq_MCF-7_Human1.51182547
34CLOCK_20551151_ChIP-Seq_293T_Human1.47313941
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41810956
36MYC_22102868_ChIP-Seq_BL_Human1.41762740
37SOX2_20726797_ChIP-Seq_SW620_Human1.40522793
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39818348
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39470223
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38422865
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.35710382
42MAF_26560356_Chip-Seq_TH1_Human1.34818512
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33569093
44BCL6_27268052_Chip-Seq_Bcells_Human1.33280931
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.31428166
46TCF7_22412390_ChIP-Seq_EML_Mouse1.31270132
47P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30227673
48BCOR_27268052_Chip-Seq_Bcells_Human1.30115766
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28275614
50GATA4_25053715_ChIP-Seq_YYC3_Human1.26008746
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25028022
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24223384
53RUNX_20019798_ChIP-Seq_JUKART_Human1.24166302
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23194776
55UTX_26944678_Chip-Seq_JUKART_Human1.23124312
56MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18799990
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18070864
58BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.17697974
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17511338
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17139046
61GATA6_25053715_ChIP-Seq_YYC3_Human1.17042397
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16389390
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16360748
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15804370
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15765532
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13286176
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12892739
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12860494
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12315195
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12072847
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11887625
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.11601208
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11073516
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.10707149
75SA1_27219007_Chip-Seq_Bcells_Human1.10629329
76KDM2B_26808549_Chip-Seq_DND41_Human1.09619159
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08656809
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07769029
79MYB_26560356_Chip-Seq_TH2_Human1.06454975
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05002628
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.04790224
82MYB_26560356_Chip-Seq_TH1_Human1.04432778
83LXR_22158963_ChIP-Seq_LIVER_Mouse1.03372098
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03046748
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01708370
86SPI1_23127762_ChIP-Seq_K562_Human1.01557344
87GATA1_19941826_ChIP-Seq_K562_Human1.00797516
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00484427
89SPI1_23547873_ChIP-Seq_NB4_Human0.97388200
90CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97035940
91ESR1_21235772_ChIP-Seq_MCF-7_Human0.95962548
92RUNX1_27514584_Chip-Seq_MCF-7_Human0.94889039
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94594638
94FOXO3_23340844_ChIP-Seq_DLD1_Human0.92568039
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91586183
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91500788
97SMC4_20622854_ChIP-Seq_HELA_Human0.90434352
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89627665
99EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89539535
100E2F1_20622854_ChIP-Seq_HELA_Human0.89464778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.15127715
2MP0010234_abnormal_vibrissa_follicle3.67278950
3MP0003303_peritoneal_inflammation3.33909542
4MP0010155_abnormal_intestine_physiology3.17944228
5MP0003436_decreased_susceptibility_to2.99128324
6MP0001835_abnormal_antigen_presentation2.98359880
7MP0005387_immune_system_phenotype2.81598164
8MP0001790_abnormal_immune_system2.81598164
9MP0000685_abnormal_immune_system2.54262518
10MP0005360_urolithiasis2.47281629
11MP0005025_abnormal_response_to2.33780337
12MP0001800_abnormal_humoral_immune2.29051710
13MP0002138_abnormal_hepatobiliary_system2.22082019
14MP0009785_altered_susceptibility_to2.21724680
15MP0005166_decreased_susceptibility_to2.18027279
16MP0000465_gastrointestinal_hemorrhage2.16832423
17MP0005671_abnormal_response_to2.15764720
18MP0002139_abnormal_hepatobiliary_system2.15494715
19MP0004264_abnormal_extraembryonic_tissu2.10119549
20MP0002796_impaired_skin_barrier2.09716094
21MP0001873_stomach_inflammation2.09668599
22MP0005000_abnormal_immune_tolerance2.09445100
23MP0004858_abnormal_nervous_system2.06393539
24MP0003866_abnormal_defecation2.00751230
25MP0002148_abnormal_hypersensitivity_rea1.98412413
26MP0001533_abnormal_skeleton_physiology1.96257738
27MP0005409_darkened_coat_color1.93268813
28MP0004782_abnormal_surfactant_physiolog1.90333316
29MP0009840_abnormal_foam_cell1.85803939
30MP0005275_abnormal_skin_tensile1.81521448
31MP0002452_abnormal_antigen_presenting1.77065945
32MP0002166_altered_tumor_susceptibility1.74050173
33MP0003300_gastrointestinal_ulcer1.73306478
34MP0004947_skin_inflammation1.71283146
35MP0010352_gastrointestinal_tract_polyps1.69119053
36MP0006082_CNS_inflammation1.67486271
37MP0002419_abnormal_innate_immunity1.67435554
38MP0001845_abnormal_inflammatory_respons1.65827448
39MP0002723_abnormal_immune_serum1.65264094
40MP0003183_abnormal_peptide_metabolism1.64815887
41MP0001666_abnormal_nutrient_absorption1.62176244
42MP0001819_abnormal_immune_cell1.62055677
43MP0002420_abnormal_adaptive_immunity1.60809696
44MP0004510_myositis1.59532122
45MP0001663_abnormal_digestive_system1.53113312
46MP0009379_abnormal_foot_pigmentation1.51627446
47MP0003191_abnormal_cellular_cholesterol1.40689694
48MP0002933_joint_inflammation1.34006146
49MP0003075_altered_response_to1.32790870
50MP0000490_abnormal_crypts_of1.30917859
51MP0003329_amyloid_beta_deposits1.28761214
52MP0000604_amyloidosis1.27838860
53MP0009333_abnormal_splenocyte_physiolog1.26632550
54MP0000477_abnormal_intestine_morphology1.22618459
55MP0005310_abnormal_salivary_gland1.21493918
56MP0002006_tumorigenesis1.21265802
57MP0008004_abnormal_stomach_pH1.20550497
58MP0005381_digestive/alimentary_phenotyp1.16878062
59MP0000343_altered_response_to1.14376179
60MP0001664_abnormal_digestion1.13501183
61MP0003448_altered_tumor_morphology1.13218092
62MP0005085_abnormal_gallbladder_physiolo1.12547326
63MP0002876_abnormal_thyroid_physiology1.11810742
64MP0000716_abnormal_immune_system1.11479084
65MP0000678_abnormal_parathyroid_gland1.11438119
66MP0005023_abnormal_wound_healing1.08689027
67MP0003763_abnormal_thymus_physiology1.08144598
68MP0003806_abnormal_nucleotide_metabolis1.07140274
69MP0002998_abnormal_bone_remodeling1.06110258
70MP0003453_abnormal_keratinocyte_physiol1.05155805
71MP0003279_aneurysm1.03278211
72MP0005058_abnormal_lysosome_morphology1.02401938
73MP0008469_abnormal_protein_level1.01157053
74MP0004019_abnormal_vitamin_homeostasis1.00456962
75MP0009764_decreased_sensitivity_to1.00038173
76MP0000249_abnormal_blood_vessel0.97236276
77MP0005464_abnormal_platelet_physiology0.94902545
78MP0005451_abnormal_body_composition0.94809212
79MP0005390_skeleton_phenotype0.93974809
80MP0002398_abnormal_bone_marrow0.93087134
81MP0000858_altered_metastatic_potential0.88384880
82MP0001216_abnormal_epidermal_layer0.85165654
83MP0002429_abnormal_blood_cell0.84942511
84MP0009278_abnormal_bone_marrow0.84499336
85MP0002136_abnormal_kidney_physiology0.84099689
86MP0002405_respiratory_system_inflammati0.83928377
87MP0009643_abnormal_urine_homeostasis0.83296708
88MP0005501_abnormal_skin_physiology0.83222615
89MP0005365_abnormal_bile_salt0.83185578
90MP0008260_abnormal_autophagy0.81072304
91MP0003045_fibrosis0.80702632
92MP0000681_abnormal_thyroid_gland0.79701966
93MP0008438_abnormal_cutaneous_collagen0.78257688
94MP0005165_increased_susceptibility_to0.75666232
95MP0002254_reproductive_system_inflammat0.75200862
96MP0005503_abnormal_tendon_morphology0.75022427
97MP0001851_eye_inflammation0.72843863
98MP0002722_abnormal_immune_system0.71048753
99MP0005164_abnormal_response_to0.69162532
100MP0002277_abnormal_respiratory_mucosa0.68605727

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.28638663
2Malnutrition (HP:0004395)5.69689880
3Eczematoid dermatitis (HP:0000976)4.62304992
4Abnormality of complement system (HP:0005339)4.36990825
5Glomerulonephritis (HP:0000099)4.31865945
6Increased IgE level (HP:0003212)4.13357610
7Complement deficiency (HP:0004431)4.07720008
8Abnormality of glutamine family amino acid metabolism (HP:0010902)3.95205043
9Gastrointestinal stroma tumor (HP:0100723)3.86348694
10Abnormality of macrophages (HP:0004311)3.79494736
11Agammaglobulinemia (HP:0004432)3.62991503
12Recurrent bronchitis (HP:0002837)3.56483660
13Vasculitis (HP:0002633)3.50878688
14Abnormality of the nasal mucosa (HP:0000433)3.50311464
15Nephritis (HP:0000123)3.45610171
16Chronic diarrhea (HP:0002028)3.38986993
17Emphysema (HP:0002097)3.36837108
18Colitis (HP:0002583)3.26421502
19Cellulitis (HP:0100658)3.17688340
20Meningitis (HP:0001287)3.08917049
21Spontaneous hematomas (HP:0007420)3.08453761
22Recurrent bacterial skin infections (HP:0005406)3.02162565
23Urticaria (HP:0001025)2.83059044
24Premature loss of primary teeth (HP:0006323)2.80584365
25Chronic otitis media (HP:0000389)2.75547536
26Abnormality of B cell number (HP:0010975)2.75344889
27Skin rash (HP:0000988)2.74776090
28Osteomyelitis (HP:0002754)2.72861898
29Inflammation of the large intestine (HP:0002037)2.71478291
30Chronic obstructive pulmonary disease (HP:0006510)2.70486778
31Obstructive lung disease (HP:0006536)2.70486778
32Recurrent abscess formation (HP:0002722)2.67975237
33Abnormality of small intestinal villus morphology (HP:0011472)2.66724255
34Villous atrophy (HP:0011473)2.66724255
35Abnormality of nail color (HP:0100643)2.64980540
36Abnormality of cells of the lymphoid lineage (HP:0012140)2.64685829
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.64109505
38Hemoptysis (HP:0002105)2.63635351
39Orchitis (HP:0100796)2.62030371
40Gastrointestinal inflammation (HP:0004386)2.61944927
41Nasal polyposis (HP:0100582)2.60459578
42Alopecia of scalp (HP:0002293)2.60332749
43Myositis (HP:0100614)2.56617736
44Gingivitis (HP:0000230)2.54636690
45Recurrent sinusitis (HP:0011108)2.53507342
46Gastrointestinal infarctions (HP:0005244)2.52127694
47Mediastinal lymphadenopathy (HP:0100721)2.50631832
48Palmoplantar hyperkeratosis (HP:0000972)2.49398708
49Pulmonary infiltrates (HP:0002113)2.48289811
50Decreased circulating renin level (HP:0003351)2.43840733
51Elevated erythrocyte sedimentation rate (HP:0003565)2.42654574
52Restrictive lung disease (HP:0002091)2.39816888
53Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35492814
54Ileus (HP:0002595)2.34930363
55Hypergammaglobulinemia (HP:0010702)2.31228248
56Purpura (HP:0000979)2.30654179
57Pustule (HP:0200039)2.30210088
58Hemorrhage of the eye (HP:0011885)2.29366440
59Recurrent gram-negative bacterial infections (HP:0005420)2.27509270
60Palmar hyperkeratosis (HP:0010765)2.27423602
61B lymphocytopenia (HP:0010976)2.26567518
62Recurrent viral infections (HP:0004429)2.26428346
63Prostate neoplasm (HP:0100787)2.26338853
64Abnormality of the prostate (HP:0008775)2.24131344
65Recurrent pneumonia (HP:0006532)2.22556482
66Plantar hyperkeratosis (HP:0007556)2.21682625
67Papilloma (HP:0012740)2.18468661
68Verrucae (HP:0200043)2.18468661
69Alkalosis (HP:0001948)2.15580205
70Skin ulcer (HP:0200042)2.12151317
71Hematochezia (HP:0002573)2.11952396
72Recurrent skin infections (HP:0001581)2.09223479
73Recurrent lower respiratory tract infections (HP:0002783)2.08801952
74Hydroxyprolinuria (HP:0003080)2.08429807
75Abnormality of proline metabolism (HP:0010907)2.08429807
76Recurrent fungal infections (HP:0002841)2.08077271
77Lymphopenia (HP:0001888)2.06716916
78Bronchitis (HP:0012387)2.06078202
79Thin bony cortex (HP:0002753)2.05506560
80Abnormality of the pleura (HP:0002103)2.01810155
81Polycythemia (HP:0001901)1.99846205
82Hyperactive renin-angiotensin system (HP:0000841)1.99831906
83Metabolic alkalosis (HP:0200114)1.99032093
84Optic neuritis (HP:0100653)1.98793619
85Retrobulbar optic neuritis (HP:0100654)1.98793619
86Chest pain (HP:0100749)1.96145709
87Right ventricular cardiomyopathy (HP:0011663)1.95073238
88Sepsis (HP:0100806)1.94273538
89Leukocytosis (HP:0001974)1.93946979
90Abnormality of the peritoneum (HP:0002585)1.92135264
91Gangrene (HP:0100758)1.91580157
92Segmental peripheral demyelination/remyelination (HP:0003481)1.87741815
93Keratoconjunctivitis sicca (HP:0001097)1.87384979
94Thick nail (HP:0001805)1.85096547
95Petechiae (HP:0000967)1.83794890
96Erythema (HP:0010783)1.82818470
97Autoimmune thrombocytopenia (HP:0001973)1.81853500
98IgA deficiency (HP:0002720)1.79467449
99Growth hormone excess (HP:0000845)1.78358722
100Ankyloglossia (HP:0010296)1.78228842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.66075833
2MAP4K13.45044526
3TYK23.05084410
4FGFR42.88282703
5MST1R2.81570816
6RIPK12.72292670
7RIPK42.46084965
8PRPF4B2.34408344
9EPHA32.10795136
10BLK2.07669107
11CDC42BPA2.00899009
12EPHB11.99503405
13JAK31.87187320
14KIT1.86063470
15ACVR1B1.79526483
16IKBKE1.73637114
17PRKG21.65846373
18GRK61.64627311
19TBK11.64285307
20ZAP701.62514726
21JAK11.61403332
22EPHA21.55784962
23IRAK41.54223621
24EPHB21.49661047
25MAP3K141.46794485
26FGFR31.46101035
27CSK1.45741086
28MAP3K11.42216076
29TRIB31.40167303
30TGFBR21.36742307
31TXK1.32334917
32DDR21.30919632
33MAP3K101.29470732
34PTK61.28590022
35JAK21.18261275
36MAP3K111.16595624
37MATK1.09666729
38FES1.09656717
39TESK21.08453117
40TAOK11.08228198
41SYK1.06405193
42PDGFRA1.05908446
43LYN1.05092118
44KDR1.04267752
45PIK3CA1.02665306
46TESK10.99244299
47FER0.95398668
48BTK0.94927891
49MAP3K130.89215572
50SMG10.88824142
51STK240.87926141
52PKN20.85717007
53IRAK30.84478852
54IRAK10.84434568
55MAP3K30.84424088
56MET0.82251492
57CSF1R0.81002646
58MAP2K20.80816428
59SIK30.73639191
60IKBKB0.72795341
61MYLK0.72512729
62HCK0.72464202
63PDPK10.70183223
64MAPK70.69615003
65BMX0.67478190
66LCK0.66263072
67NLK0.62774305
68HIPK20.62625327
69TNK20.57878671
70DMPK0.57808425
71MAP3K60.57016192
72BMPR20.56295243
73SIK10.55295985
74FGR0.54706849
75MAP2K30.53206543
76RET0.52059355
77FYN0.51460968
78MAPKAPK20.50323751
79PRKD20.49229449
80LRRK20.46991280
81PDK10.44638738
82MAP2K60.44142355
83ABL20.43427396
84ITK0.42432799
85KSR20.42207940
86TAOK20.41086366
87MAP3K120.39672456
88MAPK110.39455836
89YES10.38451367
90SRC0.38009296
91MAPK40.36284695
92RPS6KL10.36157204
93RPS6KC10.36157204
94GRK50.36014392
95PRKCD0.34446395
96PDGFRB0.33248147
97MAP3K20.32616502
98OXSR10.31765822
99PRKCQ0.31032545
100LMTK20.30254134

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.06281460
2Staphylococcus aureus infection_Homo sapiens_hsa051503.74642153
3Allograft rejection_Homo sapiens_hsa053303.43273695
4Autoimmune thyroid disease_Homo sapiens_hsa053203.28518557
5Graft-versus-host disease_Homo sapiens_hsa053323.20141222
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.19727630
7Cyanoamino acid metabolism_Homo sapiens_hsa004603.08944134
8Type I diabetes mellitus_Homo sapiens_hsa049402.67169206
9Leishmaniasis_Homo sapiens_hsa051402.40310925
10Antigen processing and presentation_Homo sapiens_hsa046122.23068300
11Fat digestion and absorption_Homo sapiens_hsa049752.20109755
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18559404
13Viral myocarditis_Homo sapiens_hsa054161.97008256
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94805404
15Renin-angiotensin system_Homo sapiens_hsa046141.91552518
16Arginine biosynthesis_Homo sapiens_hsa002201.85285769
17Sulfur metabolism_Homo sapiens_hsa009201.71356115
18Pertussis_Homo sapiens_hsa051331.68071646
19Fructose and mannose metabolism_Homo sapiens_hsa000511.57784502
20Rheumatoid arthritis_Homo sapiens_hsa053231.57412400
21Primary immunodeficiency_Homo sapiens_hsa053401.56002798
22Toxoplasmosis_Homo sapiens_hsa051451.51212617
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40330125
24Hematopoietic cell lineage_Homo sapiens_hsa046401.31596023
25Tuberculosis_Homo sapiens_hsa051521.30358022
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19651241
27Osteoclast differentiation_Homo sapiens_hsa043801.18374383
28Influenza A_Homo sapiens_hsa051641.18372981
29Arachidonic acid metabolism_Homo sapiens_hsa005901.17847089
30Protein digestion and absorption_Homo sapiens_hsa049741.15737695
31Other glycan degradation_Homo sapiens_hsa005111.12718965
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.12596911
33B cell receptor signaling pathway_Homo sapiens_hsa046621.11346998
34Systemic lupus erythematosus_Homo sapiens_hsa053221.10937405
35Linoleic acid metabolism_Homo sapiens_hsa005911.08767465
36Chemokine signaling pathway_Homo sapiens_hsa040621.03942959
37Mineral absorption_Homo sapiens_hsa049781.01373549
38Vitamin digestion and absorption_Homo sapiens_hsa049771.01285936
39Herpes simplex infection_Homo sapiens_hsa051680.99310453
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98141827
41Phagosome_Homo sapiens_hsa041450.96174326
42Complement and coagulation cascades_Homo sapiens_hsa046100.96107835
43Histidine metabolism_Homo sapiens_hsa003400.91660067
44TNF signaling pathway_Homo sapiens_hsa046680.90894164
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88556388
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81437307
47Ether lipid metabolism_Homo sapiens_hsa005650.77140351
48Malaria_Homo sapiens_hsa051440.76781746
49Hepatitis C_Homo sapiens_hsa051600.76744598
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75588798
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72508166
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.71085462
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69915410
54Galactose metabolism_Homo sapiens_hsa000520.69185618
55Pancreatic secretion_Homo sapiens_hsa049720.68543228
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67141656
57African trypanosomiasis_Homo sapiens_hsa051430.67036007
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65893583
59PPAR signaling pathway_Homo sapiens_hsa033200.65536205
60Prion diseases_Homo sapiens_hsa050200.59639566
61Amoebiasis_Homo sapiens_hsa051460.59100354
62Caffeine metabolism_Homo sapiens_hsa002320.56586118
63Arginine and proline metabolism_Homo sapiens_hsa003300.56345953
64Glycerolipid metabolism_Homo sapiens_hsa005610.55136921
65Salmonella infection_Homo sapiens_hsa051320.54218063
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.48177188
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42929290
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.42811025
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42804067
70Measles_Homo sapiens_hsa051620.42079317
71Acute myeloid leukemia_Homo sapiens_hsa052210.41157851
72Fatty acid degradation_Homo sapiens_hsa000710.40505553
73Starch and sucrose metabolism_Homo sapiens_hsa005000.39666979
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39376693
75Lysosome_Homo sapiens_hsa041420.39111569
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38655284
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.36892868
78Glutathione metabolism_Homo sapiens_hsa004800.36624382
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35672183
80Thyroid hormone synthesis_Homo sapiens_hsa049180.34859556
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34303876
82Retinol metabolism_Homo sapiens_hsa008300.33806574
83Apoptosis_Homo sapiens_hsa042100.32202336
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32010755
85Bile secretion_Homo sapiens_hsa049760.31166094
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30976846
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29571970
88GnRH signaling pathway_Homo sapiens_hsa049120.29019787
89Epstein-Barr virus infection_Homo sapiens_hsa051690.28844857
90HTLV-I infection_Homo sapiens_hsa051660.28711621
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.27628816
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27355643
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.26045748
94Chemical carcinogenesis_Homo sapiens_hsa052040.25676204
95Legionellosis_Homo sapiens_hsa051340.25662165
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24923360
97Prolactin signaling pathway_Homo sapiens_hsa049170.22890513
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.22443323
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20816351
100Shigellosis_Homo sapiens_hsa051310.19816802

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